NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2543366961|ref|WP_299255557|]
View 

acetate kinase [uncultured Cytophaga sp.]

Protein Classification

acetate kinase( domain architecture ID 10011301)

acetate kinase catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

CATH:  3.30.420.40
EC:  2.7.2.1
Gene Ontology:  GO:0008776|GO:0016310|GO:0000287|GO:0006085|GO:0005524
PubMed:  16678422

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 4-393 0e+00

acetate kinase A/propionate kinase 2; Reviewed


:

Pssm-ID: 234680  Cd Length: 402  Bit Score: 584.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   4 ILVINSGSSSLKFSLIDIATQSLLLSGIAEKLGLSNAFLIIKKDD-TKETIALASSTHQAAMEYILTYIQREGLN----- 77
Cdd:PRK00180    3 ILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGgEKEEEELPIPDHAEALKFLLNTLTDGKLGlikdl 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  78 DAIVAIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAARLFAPTLPQVAVFDTAFHQTLPDYAYLY 157
Cdd:PRK00180   83 DEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYLY 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 158 ALPMEYYRKHGVRRYGFHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVMGTRT 237
Cdd:PRK00180  163 ALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTRS 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 238 GDIDPAIIPYLANTLNISAYDVVNTFNKKSGLLGLSGLSSDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTTSL-P 316
Cdd:PRK00180  243 GDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAALnG 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2543366961 317 KVDALIFTGGIGENSSIVRSKTLKRLHVLGYTINEELNDKAVRGAHGVITTAES-IPAIVINTNEELMIALDTAACIK 393
Cdd:PRK00180  323 RLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARFGKEGDISTPDSkVKVLVIPTNEELMIARDTLRLLG 400
 
Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 4-393 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 584.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   4 ILVINSGSSSLKFSLIDIATQSLLLSGIAEKLGLSNAFLIIKKDD-TKETIALASSTHQAAMEYILTYIQREGLN----- 77
Cdd:PRK00180    3 ILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGgEKEEEELPIPDHAEALKFLLNTLTDGKLGlikdl 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  78 DAIVAIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAARLFAPTLPQVAVFDTAFHQTLPDYAYLY 157
Cdd:PRK00180   83 DEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYLY 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 158 ALPMEYYRKHGVRRYGFHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVMGTRT 237
Cdd:PRK00180  163 ALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTRS 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 238 GDIDPAIIPYLANTLNISAYDVVNTFNKKSGLLGLSGLSSDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTTSL-P 316
Cdd:PRK00180  243 GDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAALnG 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2543366961 317 KVDALIFTGGIGENSSIVRSKTLKRLHVLGYTINEELNDKAVRGAHGVITTAES-IPAIVINTNEELMIALDTAACIK 393
Cdd:PRK00180  323 RLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARFGKEGDISTPDSkVKVLVIPTNEELMIARDTLRLLG 400
AckA COG0282
Acetate kinase [Energy production and conversion];
4-393 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 573.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   4 ILVINSGSSSLKFSLIDIATQSLLLSGIAEKLGLSNAFLIIK-KDDTKETIALASSTHQAAMEYILTYIQREG---LNDA 79
Cdd:COG0282     3 ILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKdAGGEKVERELPIPDHAAALALVLELLTDHGiikDLDE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  80 IVAIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAARLFAPTLPQVAVFDTAFHQTLPDYAYLYAL 159
Cdd:COG0282    83 IDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYAL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 160 PMEYYRKHGVRRYGFHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVMGTRTGD 239
Cdd:COG0282   163 PYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 240 IDPAIIPYLANTLNISAYDVVNTFNKKsgllglsglssDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTTSLPKVD 319
Cdd:COG0282   243 IDPGVVLYLMRKEGLSADEVDDLLNKEsgllglsgissDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2543366961 320 ALIFTGGIGENSSIVRSKTLKRLHVLGYTINEELNdkAVRGAHGVITTAES-IPAIVINTNEELMIALDTAACIK 393
Cdd:COG0282   323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEAN--AARGGERVISTPDSrVKVLVIPTNEELMIARDTLRLLK 395
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 4-390 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 540.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   4 ILVINSGSSSLKFSLIDIATQSLLLSGIAEKLGLSNAFLIIKKDD-TKETIALASSTHQAAMEYILTYIQREGLN---DA 79
Cdd:cd24010     1 ILVINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVNNgEKIKEELPIPDHEEALKAILDTLTDPELGvslDE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  80 IVAIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAARLFAPTLPQVAVFDTAFHQTLPDYAYLYAL 159
Cdd:cd24010    81 IDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 160 PMEYYRKHGVRRYGFHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVMGTRTGD 239
Cdd:cd24010   161 PYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 240 IDPAIIPYLANTLNISAYDVVNTFNKKSGLLGLSGLSSDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTTSLPKVD 319
Cdd:cd24010   241 IDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2543366961 320 ALIFTGGIGENSSIVRSKTLKRLHVLGYTINEELNDKAVRGAhGVITTAES-IPAIVINTNEELMIALDTAA 390
Cdd:cd24010   321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAGGGE-REISTPDSkVKVLVIPTNEELMIARDTVR 391
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 4-386 3.14e-166

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 470.75  E-value: 3.14e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   4 ILVINSGSSSLKFSLIDIATQSLLLSGIAEKLGLSNAFLIIKKD-DTKETIALASSTHQAAMEYILTYIQREG---LNDA 79
Cdd:pfam00871   2 VLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNgGKKNAALLAGADHSEALNFILNTLLKHKiieLLAE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  80 IVAIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAARLFAPTLPQVAVFDTAFHQTLPDYAYLYAL 159
Cdd:pfam00871  82 ITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 160 PMEYYRKHGVRRYGFHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVMGTRTGD 239
Cdd:pfam00871 162 PYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSGD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 240 IDPAIIPYLANTLNISAYDVVNTFNKKSGLLGLSGLSSDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTTSLPKVD 319
Cdd:pfam00871 242 IDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLERLD 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2543366961 320 ALIFTGGIGENSSIVRSKTLKRLHVLGYTINEELNDKavRGAHGVITTAES-IPAIVINTNEELMIAL 386
Cdd:pfam00871 322 AIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNR--FGKSGVISTEDSrVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-389 2.52e-163

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 463.81  E-value: 2.52e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   1 MPSILVINSGSSSLKFSLIDIATQS-LLLSGIAEKLGLSNAFLIIKKD-DTKETIALASSTHQAAMEYILTYIQREG--- 75
Cdd:TIGR00016   3 SMKILVLNAGSSSLKFALFDAVNGEeVLASGLAERIFLPNARIKWVEDgGKKEAELLAGADHQEALKFILNTLLKDKiik 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  76 LNDAIVAIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAA-RLFA-PTLPQVAVFDTAFHQTLPDY 153
Cdd:TIGR00016  83 LLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAAlKLFPlPKAKNVAVFDTAFHQTMPEE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 154 AYLYALPMEYYRKHGVRRYGFHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVM 233
Cdd:TIGR00016 163 AYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMM 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 234 GTRTGDIDPAIIPYLANTLNISAYDVVNTFNKKSGLLGLSGLSSDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTT 313
Cdd:TIGR00016 243 GTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYIA 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2543366961 314 SLP-KVDALIFTGGIGENSSIVRSKTLKRLHVLGYTINEELNDKAVRGAHGVITTAES-IPAIVINTNEELMIALDTA 389
Cdd:TIGR00016 323 SLEgNLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARSGKSGVISTPESkVKILVIPTNEELMIAQDAI 400
 
Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 4-393 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 584.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   4 ILVINSGSSSLKFSLIDIATQSLLLSGIAEKLGLSNAFLIIKKDD-TKETIALASSTHQAAMEYILTYIQREGLN----- 77
Cdd:PRK00180    3 ILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGgEKEEEELPIPDHAEALKFLLNTLTDGKLGlikdl 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  78 DAIVAIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAARLFAPTLPQVAVFDTAFHQTLPDYAYLY 157
Cdd:PRK00180   83 DEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYLY 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 158 ALPMEYYRKHGVRRYGFHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVMGTRT 237
Cdd:PRK00180  163 ALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTRS 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 238 GDIDPAIIPYLANTLNISAYDVVNTFNKKSGLLGLSGLSSDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTTSL-P 316
Cdd:PRK00180  243 GDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAALnG 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2543366961 317 KVDALIFTGGIGENSSIVRSKTLKRLHVLGYTINEELNDKAVRGAHGVITTAES-IPAIVINTNEELMIALDTAACIK 393
Cdd:PRK00180  323 RLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARFGKEGDISTPDSkVKVLVIPTNEELMIARDTLRLLG 400
AckA COG0282
Acetate kinase [Energy production and conversion];
4-393 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 573.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   4 ILVINSGSSSLKFSLIDIATQSLLLSGIAEKLGLSNAFLIIK-KDDTKETIALASSTHQAAMEYILTYIQREG---LNDA 79
Cdd:COG0282     3 ILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKdAGGEKVERELPIPDHAAALALVLELLTDHGiikDLDE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  80 IVAIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAARLFAPTLPQVAVFDTAFHQTLPDYAYLYAL 159
Cdd:COG0282    83 IDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYAL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 160 PMEYYRKHGVRRYGFHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVMGTRTGD 239
Cdd:COG0282   163 PYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 240 IDPAIIPYLANTLNISAYDVVNTFNKKsgllglsglssDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTTSLPKVD 319
Cdd:COG0282   243 IDPGVVLYLMRKEGLSADEVDDLLNKEsgllglsgissDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2543366961 320 ALIFTGGIGENSSIVRSKTLKRLHVLGYTINEELNdkAVRGAHGVITTAES-IPAIVINTNEELMIALDTAACIK 393
Cdd:COG0282   323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEAN--AARGGERVISTPDSrVKVLVIPTNEELMIARDTLRLLK 395
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 4-390 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 540.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   4 ILVINSGSSSLKFSLIDIATQSLLLSGIAEKLGLSNAFLIIKKDD-TKETIALASSTHQAAMEYILTYIQREGLN---DA 79
Cdd:cd24010     1 ILVINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVNNgEKIKEELPIPDHEEALKAILDTLTDPELGvslDE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  80 IVAIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAARLFAPTLPQVAVFDTAFHQTLPDYAYLYAL 159
Cdd:cd24010    81 IDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 160 PMEYYRKHGVRRYGFHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVMGTRTGD 239
Cdd:cd24010   161 PYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 240 IDPAIIPYLANTLNISAYDVVNTFNKKSGLLGLSGLSSDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTTSLPKVD 319
Cdd:cd24010   241 IDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2543366961 320 ALIFTGGIGENSSIVRSKTLKRLHVLGYTINEELNDKAVRGAhGVITTAES-IPAIVINTNEELMIALDTAA 390
Cdd:cd24010   321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAGGGE-REISTPDSkVKVLVIPTNEELMIARDTVR 391
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 4-386 3.14e-166

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 470.75  E-value: 3.14e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   4 ILVINSGSSSLKFSLIDIATQSLLLSGIAEKLGLSNAFLIIKKD-DTKETIALASSTHQAAMEYILTYIQREG---LNDA 79
Cdd:pfam00871   2 VLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNgGKKNAALLAGADHSEALNFILNTLLKHKiieLLAE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  80 IVAIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAARLFAPTLPQVAVFDTAFHQTLPDYAYLYAL 159
Cdd:pfam00871  82 ITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 160 PMEYYRKHGVRRYGFHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVMGTRTGD 239
Cdd:pfam00871 162 PYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSGD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 240 IDPAIIPYLANTLNISAYDVVNTFNKKSGLLGLSGLSSDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTTSLPKVD 319
Cdd:pfam00871 242 IDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLERLD 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2543366961 320 ALIFTGGIGENSSIVRSKTLKRLHVLGYTINEELNDKavRGAHGVITTAES-IPAIVINTNEELMIAL 386
Cdd:pfam00871 322 AIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNR--FGKSGVISTEDSrVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-389 2.52e-163

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 463.81  E-value: 2.52e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   1 MPSILVINSGSSSLKFSLIDIATQS-LLLSGIAEKLGLSNAFLIIKKD-DTKETIALASSTHQAAMEYILTYIQREG--- 75
Cdd:TIGR00016   3 SMKILVLNAGSSSLKFALFDAVNGEeVLASGLAERIFLPNARIKWVEDgGKKEAELLAGADHQEALKFILNTLLKDKiik 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  76 LNDAIVAIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAA-RLFA-PTLPQVAVFDTAFHQTLPDY 153
Cdd:TIGR00016  83 LLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAAlKLFPlPKAKNVAVFDTAFHQTMPEE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 154 AYLYALPMEYYRKHGVRRYGFHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVM 233
Cdd:TIGR00016 163 AYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMM 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 234 GTRTGDIDPAIIPYLANTLNISAYDVVNTFNKKSGLLGLSGLSSDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTT 313
Cdd:TIGR00016 243 GTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYIA 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2543366961 314 SLP-KVDALIFTGGIGENSSIVRSKTLKRLHVLGYTINEELNDKAVRGAHGVITTAES-IPAIVINTNEELMIALDTA 389
Cdd:TIGR00016 323 SLEgNLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARSGKSGVISTPESkVKILVIPTNEELMIAQDAI 400
PRK12379 PRK12379
propionate kinase;
2-389 6.46e-152

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 434.55  E-value: 6.46e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   2 PSILVINSGSSSLKFSLIDIATQSLLLSGIAEKLGLSNAFLIIKKDdtkETIALASSTHQAAMEYILTYIQREGLNDAIV 81
Cdd:PRK12379    5 PVVLVINCGSSSIKFSVLDASDCEVLMSGIADGINSENAFLSVNGG---EPAPLAHHSYEGALKAIAFELEKRNLNDSVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  82 AIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAARLFAPTLPQVAVFDTAFHQTLPDYAYLYALPM 161
Cdd:PRK12379   82 LIGHRIAHGGSIFTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTLAPEAYLYGLPW 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 162 EYYRKHGVRRYGFHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVMGTRTGDID 241
Cdd:PRK12379  162 EYYEELGVRRYGFHGTSHRYVSQRAHSLLNLDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRSGDVD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 242 PAIIPYLANTLNISAYDVVNTFNKKSGLLGLSGLSSDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTTSLPKVDAL 321
Cdd:PRK12379  242 FGAMAWIASQTGQTLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERAQLAIKTFVHRIARHIAGHAASLHRLDGI 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2543366961 322 IFTGGIGENSSIVRSKTLKRLHVLGYTINEELNDKAVRGAHGVITTAES-IPAIVINTNEELMIALDTA 389
Cdd:PRK12379  322 IFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNQPNSGGERIISSENSrVICAVIPTNEEKMIALDAI 390
PRK12440 PRK12440
acetate/propionate family kinase;
4-385 8.57e-129

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 376.12  E-value: 8.57e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   4 ILVINSGSSSLKFSLIDIATQSLLLSGIAEKLGLSNAFLIIKKDDTKETIAL--ASSTHQAAMEYILTYIQREGLNDAIV 81
Cdd:PRK12440    6 VLVINSGSSSLKFAVIDSVTGEAVLSGLGECFGLEDARMSWKYQGEKTEIAIegEDNHHKIAIGRLVGLTEELGFTQDIV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  82 AIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAARLFAPTLPQVAVFDTAFHQTLPDYAYLYALPM 161
Cdd:PRK12440   86 AVGHRIVHGGEKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPKKAFTGAIAK 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 162 EYYRKHGVRRYGFHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVMGTRTGDID 241
Cdd:PRK12440  166 ELYTDFGIRRYGFHGTSHYFVSREAAKMLNKPIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMMGTRCGDLD 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 242 PAIIPYLANTlNISAYDVVNTFNKKSGLLGLSGLSSDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTTSLPKVDAL 321
Cdd:PRK12440  246 PGIIEFLLKK-GWSQEKVFNSLNKKSGFLGVSGLTSDARGILEAMEEGHEGATLAFEVFTYRVAKYIASYLAALDSLDGI 324

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2543366961 322 IFTGGIGENSSIVRSKTLKRLHVLGYTINEELNDKAVRGAHGVITTAESIPAI--VINTNEELMIA 385
Cdd:PRK12440  325 IFTGGIGENSLPIRREILKNLKLLGFVEDEKGNEDARFGKAGIIAKSELLNAVamVIPTNEEFVIA 390
PRK12397 PRK12397
acetate/propionate family kinase;
4-387 2.78e-118

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 349.52  E-value: 2.78e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   4 ILVINSGSSSLKFSLIDIATQSLLLSGIAEKLGLSNAFLIIKKDDTK--ETIALASstHQAAMEYIL-TYIQREGLN--D 78
Cdd:PRK12397    5 IMAINAGSSSLKFQLLEMPQGDMLCQGLIERIGMADAQVTIKTHSQKwqETVPVAD--HRDAVTLLLeKLLGYQIINslR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  79 AIVAIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAARLFAPTLPQVAVFDTAFHQTLPDYAYLYA 158
Cdd:PRK12397   83 DIDGVGHRVAHGGEFFKDSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEPAYIYP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 159 LPMEYYRKHGVRRYGFHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVMGTRTG 238
Cdd:PRK12397  163 LPWRYYAELGIRRYGFHGTSHKYVSGVLAEKLGVPLSALRVICCHLGNGSSICAIKNGRSVNTSMGFTPQSGVMMGTRSG 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 239 DIDPAIIPYLANTLNISAYDVVNTFNKKSGLLGLSGLSSDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTTSLPKV 318
Cdd:PRK12397  243 DIDPSILPWIAQREGKTPQQLNQLLNNESGLLGVSGVSSDYRDVEQAANTGNRQAKLALTLFAERIRATIGSYIMQMGGL 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2543366961 319 DALIFTGGIGENSSIVRSKTLKRLHVLGYTINEELNDKA---VRGAHGVITTAesipaiVINTNEELMIALD 387
Cdd:PRK12397  323 DALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNQRNatfIQTENALVKVA------VINTNEELMIAQD 388
PRK07157 PRK07157
acetate kinase; Provisional
 1-387 1.80e-113

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 337.10  E-value: 1.80e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   1 MPSILVINSGSSSLKFSLIDIATQSLLLSGIAEKLGLSNAFLIIKKDDTKETIALASSTHQAAMEYILTYIQREGL-NDA 79
Cdd:PRK07157    2 KAKILVINAGSSSIKWQLFDKENLNLIASGLAERIGLENGLIKIKFGKKKYEKEVDMPNHKVAVAVLIEIWEENKLiEDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  80 --IVAIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAARLFAPTLPQVAVFDTAFHQTLPDYAYLY 157
Cdd:PRK07157   82 eeIELIGFRVVHGGDYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKINYTY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 158 ALPMEYYRKHGVRRYGFHGTSHQYVSQQAALLLNKDlgDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVMGTRT 237
Cdd:PRK07157  162 PINYEIAKKYGIKKYGFHGISHKFITNKVEKILNKD--KVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAGVMMGTRS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 238 GDIDPAIIPYLANTLNISAYDVVNTFNKKSGLLGLSGLSSDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTTSL-P 316
Cdd:PRK07157  240 GDIDPSIHEFVAKEANMSISEFTDLLNKKSGLLGVSGISSDLRDVIKAAESGNKRAKFALDLYAQKIVDYLANYINKIgK 319

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2543366961 317 KVDALIFTGGIGENSSIVRSKTLKRLHVLGYTINEELNDKAVR--GAHGVITTAES-IPAIVINTNEELMIALD 387
Cdd:PRK07157  320 KIDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLKKIGeyGPIELISTPDSdIPVYVIRTNEELLIAKN 393
PRK07058 PRK07058
acetate/propionate family kinase;
78-390 2.57e-82

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 256.90  E-value: 2.57e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  78 DAIVAIGHRVVHGGEFFKSAVLIDDAVIKIIEDCIAFAPLHNPAHLEGIYAARLFAPTLPQVAVFDTAFHQTLPDYAYLY 157
Cdd:PRK07058   84 SELVAVGHRVVHGGDRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFDTAFHRTQPDLVRRF 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 158 ALPMEYYrKHGVRRYGFHGTSHQYVSQQAAlLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFTPLEGLVMGTRT 237
Cdd:PRK07058  164 AIPRALH-DEGIKRYGFHGLSYKFVAGELR-RRAPELARGKVVAAHLGSGASLCALDAGKSRDTSMGFSTLDGIPMATRC 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 238 GDIDPAIIPYLANTLNISAYDVVNTFNKKSGLLGLSGLSSDMRELQEAAAGGHRGaaiTIEVFVHRLAKYIGAMTTSLPK 317
Cdd:PRK07058  242 GALDPGVVLHLLKQEGMSLDEVEDLLYHRSGLLGVSGISGDTRDLLASDAPEARE---ALDLFALRIAGEIARLAATLGG 318

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2543366961 318 VDALIFTGGIGENSSIVRSKTLKRLHVLGYTINEELNDkavRGAhGVITTAES-IPAIVINTNEELMIALDTAA 390
Cdd:PRK07058  319 LDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANA---ANA-FTISSRTSrVAAFVIPTDEEQVIADEAFS 388
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 4-327 3.60e-17

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 81.81  E-value: 3.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   4 ILVINSGSSSLKFSLIDiatqslllsgiAEKLGLSNAFliikKDDTKETIALASSTHQAA--MEYILTYIQREGLN---- 77
Cdd:cd24011     2 ILVINPGSTSTKIAVFE-----------GEEEVFEETI----EHSPEELAKFPSIIDQLEfrKEAVLDFLKENGIDlsdl 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  78 DAIVAIGHRV--VHGGeffksAVLIDDaviKIIEDCIAFAPLHNPAHLEGIYAARLFAPTLPQVAVFDTAFHQTLPDYAY 155
Cdd:cd24011    67 DAIVGRGGLLkpIPGG-----TYRVNE---AMLEDLLSGPLGEHASNLGAPIAYELAKEYGIPAYIVDPVVVDEMDPVAR 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 156 LYALPmeyyrkhGVRRYG-FHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVDTSMGFtPLEGlVMG 234
Cdd:cd24011   139 ITGIP-------EIERRSiFHALNQKAVARRAAKELGKPYEELNLIVAHLGGGISVGAHRKGRVIDVNNAL-DGEG-PFS 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 235 T-RTGDIDPAIIPYLANTLNISAYDVVNtFNKKSGLLGLSGLSSDMRELQEAAAGGHRGAAITIEVFVHRLAKYIGAMTT 313
Cdd:cd24011   210 PeRAGTLPVGDLIKLCFSGKYTLEELKK-KLKGKGGLVAYLGTNDFREVEKRIEAGDEKAKLVLDAMAYQIAKEIGALAA 288

                         330
                  ....*....|....*
gi 2543366961 314 SLP-KVDALIFTGGI 327
Cdd:cd24011   289 VLKgKVDAIILTGGL 303
PRK03011 PRK03011
butyrate kinase; Provisional
 1-334 3.52e-10

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 60.94  E-value: 3.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961   1 MPSILVINSGSSSLKFSLIDiatqslllsgiaeklglsNAFLIIKKD---DTKETIALASSTHQAAM--EYILTYIQREG 75
Cdd:PRK03011    1 MMRILVINPGSTSTKIAVFE------------------DEKPIFEETlrhSAEELEKFKTIIDQYEFrkQAILDFLKEHG 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961  76 LN----DAIVAIGH--RVVHGGEFfksavLIDDAvikIIEDCIAFAPLHNPAHLEGIYAARLfAPTL--------PQVAv 141
Cdd:PRK03011   63 IDlselDAVVGRGGllKPIPGGTY-----RVNEA---MLEDLKNGKYGEHASNLGAIIAYEI-AKELgipafivdPVVV- 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 142 fDTafhqtLPDYAYLYALPmeyyrkhGVRRYG-FHGTSHQYVSQQAALLLNKDLGDSGFITAHLGNGASVSAVLNGKSVD 220
Cdd:PRK03011  133 -DE-----MEPVARISGLP-------EIERKSiFHALNQKAVARRVAKELGKKYEELNLIVAHLGGGISVGAHRKGRVID 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366961 221 TSMG------FTPLeglvmgtRTGDIdpaiiPylantlnisAYDVVN-TFNKKSGLLGLSGLSS------------DMRE 281
Cdd:PRK03011  200 VNNAldgegpFSPE-------RAGGL-----P---------VGDLVElCFSGKYTKEELKKKLVgkgglvaylgtnDARE 258

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2543366961 282 LQEAAAGGHRGAAITIEVFVHRLAKYIGAMTTSLP-KVDALIFTGGIGENSSIV 334
Cdd:PRK03011  259 VEKRIEEGDEKAKLVYEAMAYQIAKEIGAMAAVLKgKVDAIVLTGGLAYSKRLV 312
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH