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Conserved domains on  [gi|2543669057|ref|WP_299536200|]
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iron ABC transporter permease [uncultured Streptomyces sp.]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 57-356 4.30e-82

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 252.30  E-value: 4.30e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  57 SPARAWEFLTGDPAaraDAQLRLAVMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTF 136
Cdd:COG0609    10 SLSDVLRALLGPDG---DPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIVL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 137 FGANSSTSLLVWALLGGITASAVVLLMASSGRtSSSPLRLVLAGSALGATFHGLTSYVLL-GTQSTFDTYRYWTIGSLAG 215
Cdd:COG0609    87 GGGLSALGLPLAAFLGALLAALLVYLLARRGG-GLSPLRLVLAGVAVSALFSALTSLLLLlADPEQLRSIVFWLMGSLAG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 216 VKAAALLPLLPLIAVGLATAFACARPLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAA 295
Cdd:COG0609   166 ASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPHIA 245

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2543669057 296 RVVAGARMAAQLLLSALIAANVMIFADILARIVIRPWETPVSVLLAFVGGPLLIWIARSSR 356
Cdd:COG0609   246 RLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 57-356 4.30e-82

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 252.30  E-value: 4.30e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  57 SPARAWEFLTGDPAaraDAQLRLAVMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTF 136
Cdd:COG0609    10 SLSDVLRALLGPDG---DPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIVL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 137 FGANSSTSLLVWALLGGITASAVVLLMASSGRtSSSPLRLVLAGSALGATFHGLTSYVLL-GTQSTFDTYRYWTIGSLAG 215
Cdd:COG0609    87 GGGLSALGLPLAAFLGALLAALLVYLLARRGG-GLSPLRLVLAGVAVSALFSALTSLLLLlADPEQLRSIVFWLMGSLAG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 216 VKAAALLPLLPLIAVGLATAFACARPLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAA 295
Cdd:COG0609   166 ASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPHIA 245

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2543669057 296 RVVAGARMAAQLLLSALIAANVMIFADILARIVIRPWETPVSVLLAFVGGPLLIWIARSSR 356
Cdd:COG0609   246 RLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 57-353 6.29e-71

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 223.94  E-value: 6.29e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  57 SPARAWEFLTGDpaarADAQLRLAVMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTF 136
Cdd:pfam01032  18 SPSDVFSALLGG----DDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAVLAILL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 137 FGANSSTSLLVWALLGGITASAVVLLmASSGRTSSSPLRLVLAGSALGATFHGLTSYVL-LGTQSTFDTYRYWTIGSLAG 215
Cdd:pfam01032  94 GGSLSLFALPLAAFIGALLAALLVYF-LSRGRGGASPLRLILAGIAVSALLSALTSLLLlLLNPEALQSILFWLMGSLSG 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 216 VKAAALLPLLPLIAVGLATAFACARPLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAA 295
Cdd:pfam01032 173 ANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVGLIVPHIA 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2543669057 296 RVVAGARMAAQLLLSALIAANVMIFADILARIVIRPWETPVSVLLAFVGGPLLIWIAR 353
Cdd:pfam01032 253 RLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLL 310
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
81-360 9.83e-59

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 193.38  E-value: 9.83e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  81 VMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTFFGANSSTSLLVWALLGGITASAVV 160
Cdd:PRK10441   56 VLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIV 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 161 LLMASSGRTSSSPLRLVLAGSALGATFHGLTSYVLLGTQSTFDTYRYWTIGSLAGVKAAALLPLLPLIAVGLATAFACAR 240
Cdd:PRK10441  136 AFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSR 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 241 PLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAARVVAGARMAAQLLLSALIAANVMIF 320
Cdd:PRK10441  216 ALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLF 295

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2543669057 321 ADILARIVIrPWETPVSVLLAFVGGPLLIWIARSSRLSTA 360
Cdd:PRK10441  296 ADIIGRLLV-PGELRVSVVSAFIGAPVLIFLVRRKTRGGA 334
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 89-351 1.20e-42

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 149.24  E-value: 1.20e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  89 TFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTFFGANSSTSLLVWALLGGITASAVVLLMASSGR 168
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 169 tsSSPLRLVLAGSALGATFHGLTSYVLLGTQSTFDTYRYWTIGSLAGVKAAALLPLLPLIAVGLATAFACARPLSALGLG 248
Cdd:cd06550    81 --LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 249 DDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAARVVAGARMAAQLLLSALIAANVMIFADILARIV 328
Cdd:cd06550   159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                         250       260
                  ....*....|....*....|...
gi 2543669057 329 IrPWETPVSVLLAFVGGPLLIWI 351
Cdd:cd06550   239 L-PSELPVGPVTALLGAPYFLYL 260
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 57-356 4.30e-82

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 252.30  E-value: 4.30e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  57 SPARAWEFLTGDPAaraDAQLRLAVMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTF 136
Cdd:COG0609    10 SLSDVLRALLGPDG---DPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIVL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 137 FGANSSTSLLVWALLGGITASAVVLLMASSGRtSSSPLRLVLAGSALGATFHGLTSYVLL-GTQSTFDTYRYWTIGSLAG 215
Cdd:COG0609    87 GGGLSALGLPLAAFLGALLAALLVYLLARRGG-GLSPLRLVLAGVAVSALFSALTSLLLLlADPEQLRSIVFWLMGSLAG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 216 VKAAALLPLLPLIAVGLATAFACARPLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAA 295
Cdd:COG0609   166 ASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPHIA 245

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2543669057 296 RVVAGARMAAQLLLSALIAANVMIFADILARIVIRPWETPVSVLLAFVGGPLLIWIARSSR 356
Cdd:COG0609   246 RLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 57-353 6.29e-71

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 223.94  E-value: 6.29e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  57 SPARAWEFLTGDpaarADAQLRLAVMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTF 136
Cdd:pfam01032  18 SPSDVFSALLGG----DDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAVLAILL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 137 FGANSSTSLLVWALLGGITASAVVLLmASSGRTSSSPLRLVLAGSALGATFHGLTSYVL-LGTQSTFDTYRYWTIGSLAG 215
Cdd:pfam01032  94 GGSLSLFALPLAAFIGALLAALLVYF-LSRGRGGASPLRLILAGIAVSALLSALTSLLLlLLNPEALQSILFWLMGSLSG 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 216 VKAAALLPLLPLIAVGLATAFACARPLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAA 295
Cdd:pfam01032 173 ANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVGLIVPHIA 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2543669057 296 RVVAGARMAAQLLLSALIAANVMIFADILARIVIRPWETPVSVLLAFVGGPLLIWIAR 353
Cdd:pfam01032 253 RLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLL 310
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
81-360 9.83e-59

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 193.38  E-value: 9.83e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  81 VMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTFFGANSSTSLLVWALLGGITASAVV 160
Cdd:PRK10441   56 VLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIV 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 161 LLMASSGRTSSSPLRLVLAGSALGATFHGLTSYVLLGTQSTFDTYRYWTIGSLAGVKAAALLPLLPLIAVGLATAFACAR 240
Cdd:PRK10441  136 AFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSR 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 241 PLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAARVVAGARMAAQLLLSALIAANVMIF 320
Cdd:PRK10441  216 ALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLF 295

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2543669057 321 ADILARIVIrPWETPVSVLLAFVGGPLLIWIARSSRLSTA 360
Cdd:PRK10441  296 ADIIGRLLV-PGELRVSVVSAFIGAPVLIFLVRRKTRGGA 334
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
73-358 9.73e-55

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 190.44  E-value: 9.73e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  73 ADAQLRLAVMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTFFGANSSTSLLVWALLG 152
Cdd:PRK10577  385 LSGQLLDALLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLG 464

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 153 GITASAVVLLMAssGRTSSSPLRLVLAGSALGATFHGLTSYVLLGTQSTFDTYRYWTIGSLAGVKAAALLPLLPLIAVGL 232
Cdd:PRK10577  465 ALAALALILLLA--RRGGFAPERLLLTGIALSALFTALIQLLLASGDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLLL 542

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 233 ATAFACARPLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAARVVAGARMAAQLLLSAL 312
Cdd:PRK10577  543 ALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAAL 622

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2543669057 313 IAANVMIFADILARIVIRPWETPVSVLLAFVGGPLLIWIARSSRLS 358
Cdd:PRK10577  623 LGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRSRRR 668
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 57-356 1.77e-52

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 177.24  E-value: 1.77e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  57 SPARAWEFLTGDpaarADAQLRLAVMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTF 136
Cdd:COG4779    49 SPGDVLRALLGE----GDPGASFVVLELRLPRALAALLVGAALGLSGAIFQSLTRNPLASPDIIGITAGASAGAVAAIVV 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 137 FGAnSSTSLLVWALLGGITASAVVLLMAssGRTSSSPLRLVLAGSALGATFHGLTSYVLL--GTQSTFDTYRyWTIGSLA 214
Cdd:COG4779   125 LGG-SGLAVALGALAGGLATALLVYLLA--WRGGVSGYRLILVGIGVSAMLTAVNSYLLTraDLEDAQSAAV-WLTGSLN 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 215 GVKAAALLPLLPLIAVGLATAFACARPLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYA 294
Cdd:COG4779   201 GRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAVALAAVATAAAGPIAFVALAAPQI 280

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2543669057 295 ARVVAGARmAAQLLLSALIAANVMIFADILARIVIRPWETPVSVLLAFVGGPLLIW-IARSSR 356
Cdd:COG4779   281 ARRLTRSP-GPPLLPSALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLLWlLIRENR 342
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
63-364 5.66e-51

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 180.03  E-value: 5.66e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  63 EFLTGDPAARADAQLRLAVMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTFFGANSS 142
Cdd:PRK10577   40 QWLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLALVLATLFAPALLA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 143 TSLLVWALLGGITASAVVLLMAssGRTSSSPLRLVLAGSALGATFHGLTSYVLLGTQSTFDTYRYWTIGSLAGVKAAALL 222
Cdd:PRK10577  120 LASQLAAFAGGLLAAALVFALA--GGKRLSPLRLVLAGMVVSLYLGALTTLLLLFNEQYLQGLFLWGAGSLAQNDWSGVQ 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 223 PLLPLIAVGLATAFACARPLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAARVVAGAR 302
Cdd:PRK10577  198 RLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIGFIGLAAPNLARLLGARR 277

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2543669057 303 MAAQLLLSALIAANVMIFADILARIVIRPW--ETPVSVLLAFVGGPLLIWIARSSRLSTAGASA 364
Cdd:PRK10577  278 LRARLPLSPLIGALLLLLTDQLVRLLAGVGgeLLPTGAVTALIGAPLLLWLLPRLRSAQSAPAM 341
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
55-353 1.31e-45

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 158.70  E-value: 1.31e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  55 SSSPARAWEFLTGDPAARADAQLRLAVMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGL 134
Cdd:PRK11228   21 SAIPISAADALNALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 135 TFFGAN-SSTSLLVWALLGGITASAVVLLMASSGRTSSSPLRLVLAGSALGATFHGLTSYVLLGTQSTFDTYRYWTIGSL 213
Cdd:PRK11228  101 ALSPTPfAGYSLAFIAACGGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHAYGIFYWLAGGV 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 214 AGVKAAALLPLLPLIAVGLATAFACARPLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPY 293
Cdd:PRK11228  181 SHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPH 260

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 294 AARVVAGARMAAQLLLSALIAANVMIFADILARIVIRPWETPVSVLLAFVGGPLLIWIAR 353
Cdd:PRK11228  261 LARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLAR 320
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 89-351 1.20e-42

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 149.24  E-value: 1.20e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  89 TFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTFFGANSSTSLLVWALLGGITASAVVLLMASSGR 168
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 169 tsSSPLRLVLAGSALGATFHGLTSYVLLGTQSTFDTYRYWTIGSLAGVKAAALLPLLPLIAVGLATAFACARPLSALGLG 248
Cdd:cd06550    81 --LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 249 DDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAARVVAGARMAAQLLLSALIAANVMIFADILARIV 328
Cdd:cd06550   159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                         250       260
                  ....*....|....*....|...
gi 2543669057 329 IrPWETPVSVLLAFVGGPLLIWI 351
Cdd:cd06550   239 L-PSELPVGPVTALLGAPYFLYL 260
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
80-351 2.47e-39

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 142.11  E-value: 2.47e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  80 AVMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTFFGANSSTSLLVWALLGGITASAV 159
Cdd:PRK09777   46 VLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASLASVGALLLFPSLPVMWLPLLAFIGGMAGLIL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 160 VLLMASSgrtsSSPLRLVLAGSALGATFHGLTSYVLLGTQSTFDTYRYWTIGSLAGVKAAALLPLLPLIAVGLATAFACA 239
Cdd:PRK09777  126 LKMLAGT----HQPMKLALTGVALSALWASLTDYLMLSRPQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFC 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 240 RPLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAARVVAGARMAAQLLLSALIAANVMI 319
Cdd:PRK09777  202 RDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLL 281

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2543669057 320 FADILARIVIRPWETPVSVLLAFVGGPLLIWI 351
Cdd:PRK09777  282 LADLLARIIHPPLELPAGVLTAIIGAPWFFWL 313
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 78-351 2.88e-39

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 141.91  E-value: 2.88e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  78 RLAVMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTFF-GANSSTSLLVWALLGGITA 156
Cdd:COG4139    48 QLFVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGgGLLPPWLLSLAAIAGALLV 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 157 SAVVLLMASSGRTSSsplRLVLAGSALGATFHGLTSY-VLLGTQSTFDTYRYWTIGSLAGVKAAALLPLLPLIAVgLATA 235
Cdd:COG4139   128 TLLLLAFARRRLSNA---RLLLIGVALGIICSAIMTWaVYFSSSLDLRQLMYWMMGSFGGVDWRQLWLLLALLPV-LLWL 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 236 FACARPLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAARVVAGARMAAQLLLSALIAA 315
Cdd:COG4139   204 CLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGA 283

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2543669057 316 NVMIFADILARIVIRPWETPVSVLLAFVGGPLLIWI 351
Cdd:COG4139   284 ALLLLADIIARLALSSAELPIGVVTATLGAPVFIWL 319
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 78-350 8.55e-36

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 132.77  E-value: 8.55e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  78 RLAVMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTFF-GANSSTSLLVWALLGGITA 156
Cdd:PRK03784   51 ELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGqGLLPPWALSLCAIAGALLI 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 157 SAVVLLMASSGRTSSSplRLVLAGSALGATFHGLTSY-VLLGTQSTFDTYRYWTIGSLAGVKAAALLPLLPLIAVGLATA 235
Cdd:PRK03784  131 TLILLRFARRHRLSTS--RLLLAGVALGIICSALMTWaVYFSTSLDLRQLMYWMMGGFGGVDWRQSWLMLALLPVLIWLC 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 236 fACARPLSALGLGDDSARSLG--HHPGRVRLVVAgaVSLLAGCAVAIAGPIAFLGLLAPYAARVVAGARMAAQLLLSALI 313
Cdd:PRK03784  209 -CQGRPLNMLALGEISARQLGlpLWFWRNLLVLA--TGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALA 285

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2543669057 314 AANVMIFADILARIVIRPWETPVSVLLAFVGGPLLIW 350
Cdd:PRK03784  286 GASLLLLADIVARLALASAELPIGVVTATLGAPVFIW 322
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
57-351 1.23e-28

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 113.65  E-value: 1.23e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  57 SPARAWEFLTGDpaarADAQLRLAVMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTF 136
Cdd:PRK10440   35 ETSQVFAALMGD----APRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVAMVL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 137 FGANSsTSLLVWALLGGITASAVVLLMAssGRTSSSPLRLVLAGSALGATFHGLTSYVLL-GTQSTFDTYRYWTIGSLAG 215
Cdd:PRK10440  111 FGQDL-TAIALAAMAGGIVTSLLVWLLA--WRNGIDTFRLIIIGIGVRAMLVAFNTWLLLkASLETALTAGLWNAGSLNG 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 216 VKAAALLPLLPLIAVGLATAFACARPLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAA 295
Cdd:PRK10440  188 LTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPISFIALVAPHIA 267

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2543669057 296 RVVAGARmAAQLLLSALIAANVMIFADILARIVIRPWETPVSVLLAFVGGPLLIWI 351
Cdd:PRK10440  268 RRLSGTA-RWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIVL 322
btuC PRK09535
cobalamin ABC transporter permease BtuC;
78-353 6.05e-27

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 109.45  E-value: 6.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  78 RLAVMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTFfGANSSTSLLVWALLGGITAS 157
Cdd:PRK09535   88 QTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVL-PLAVPFGLQAAAFAGALVAA 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 158 AVVLLMAS-SGRTSSSPLrlVLAGSALGATFHGLTSYVLLGTQSTFDTYRYWTIGSLAGVKAAALLPLLPLIAVGLATAF 236
Cdd:PRK09535  167 FGVYAIATeNGRTPVATL--LLAGVAVQTFLGAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLL 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 237 ACARPLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAARVVAGARMAAQLLLSALIAAN 316
Cdd:PRK09535  245 AYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGAS 324

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2543669057 317 VMIFADILARivIRPWETPVSVLLAFVGGPLLIWIAR 353
Cdd:PRK09535  325 FLVATDTVAR--SGPAEVPVGIVTAALGAPFFLYLLR 359
CeuC COG4605
ABC-type enterochelin transport system, permease component [Inorganic ion transport and ...
 81-357 7.50e-14

ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443655  Cd Length: 317  Bit Score: 71.29  E-value: 7.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057  81 VMDVRLPRTFAGALVGICLGTAGCLLQAATRNPLAETGLLGVNAGAAFAVVLGLTFFGansSTSLLVWALLGGITASAVV 160
Cdd:COG4605    35 ILPRRGTKLAAMLLVAIAIAVSTVLFQTITNNRILTPSIMGFDSLYVLIQTLLVFFLG---SAGLAALNPLLNFLLEVAL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 161 LLMASS-------GRTSSSPLRLVLAGSALGATFHGLTSYV-LLGTQSTFDTYRYWTIGSLAGVKAAALLPLLPLIAVGL 232
Cdd:COG4605   112 MVGFSLllyrwlfRGGRRNLHLLLLVGVVLGTLFRSLSSFLqRLIDPNEFDVLQDRLFASFNNVNTDLLLIAAVIVLLAL 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543669057 233 ATAFACARPLSALGLGDDSARSLGHHPGRVRLVVAGAVSLLAGCAVAIAGPIAFLGLLAPYAARVVAG-ARMAAQLLLSA 311
Cdd:COG4605   192 LLLWRLRRRLDVLALGRDQAINLGVDYRRVVRRLLILVAVLVAVSTALVGPITFLGLLVANLAYQLFGtYRHRYLLPAAA 271

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2543669057 312 LIAANVMIFADILARIVIRpWETPVSVLLAFVGGPLLIW-IARSSRL 357
Cdd:COG4605   272 LIGVIALVGGQFVVEHVFN-FSTTLSVIIEFVGGIYFLYlLLRKRRL 317
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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