|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
26-431 |
1.57e-99 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 301.43 E-value: 1.57e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 26 LILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLA 105
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 106 CAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVGG 185
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 186 AIPLCCLPFYLwlvpesarfmvvrhypaqriartlarvcggsfaadqtfsvseppvksgqpakvllsdsyrkTTLSLWGT 265
Cdd:cd17365 161 VPPLILLPLLR-------------------------------------------------------------GTLLLWVT 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 266 YFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLACGSVQ 345
Cdd:cd17365 180 FFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPAS 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 346 SGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAVIAILAVPATL 425
Cdd:cd17365 260 LVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAAL 339
|
....*.
gi 2543671686 426 AALIIV 431
Cdd:cd17365 340 GALAVL 345
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
8-406 |
5.50e-98 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 299.27 E-value: 5.50e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 8 DVRSHINGRKMSGYQWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYG 87
Cdd:TIGR00895 1 DVQNNIRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 88 RKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFL 167
Cdd:TIGR00895 81 RRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 168 AAALLPEHGWRSVLMVGGAIPLCCLPFYLWLVPESARFMVVRhypAQRIARTLARVCGGSFAADQTFSVSEPPVKSGQ-- 245
Cdd:TIGR00895 161 AGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSK---RPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTkr 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 246 -PAKVLLSDSYRKTTLSLWGTYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPsRA 324
Cdd:TIGR00895 238 sVFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGP-RV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 325 IAAAYIAGAVFILLLACGSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGV 404
Cdd:TIGR00895 317 TALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGY 396
|
..
gi 2543671686 405 LL 406
Cdd:TIGR00895 397 LL 398
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
24-441 |
5.55e-65 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 214.06 E-value: 5.55e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 24 LLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCS 103
Cdd:PRK11551 15 LTIGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 104 LACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGsGLVGFLAAALLPEH-GWRSVLM 182
Cdd:PRK11551 95 LATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFG-GALASVIGVLAAGDaAWRHIFY 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 183 VGGAIPLCCLPFYLWLVPESARFMVVRHYPAQRiartlarvcggsfaadqtfsvsePPVksgqpAKVLLSDSYRKTTLSL 262
Cdd:PRK11551 174 VGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQR-----------------------APV-----LRALFGEGRATATLLL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 263 WGTYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLAcG 342
Cdd:PRK11551 226 WISYFFTLIVLYFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGILASLAALA-A 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 343 SVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAVIAILAvP 422
Cdd:PRK11551 305 APSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLALGRSTVGVIGASI-P 383
|
410
....*....|....*....
gi 2543671686 423 ATLAALIIVFIQMGQRPAA 441
Cdd:PRK11551 384 VILVAALAALLLVSRPSRA 402
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-433 |
1.75e-46 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 164.27 E-value: 1.75e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 16 RKMSGYQWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTA 95
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 96 VAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEH 175
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 176 GWRSVLMVGGAIPLCCLPFYLWLvpesarfmvvrhypaqriartlarvcggsfaadqtfsvseppvksgqpakvllsdsy 255
Cdd:COG2271 162 GWRAAFLILGLPGLLLALLRFWL--------------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 256 rkttlsLWGTYFMGLLVIYLLSGWLPTLIKDA-GLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAV 334
Cdd:COG2271 185 ------LALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLA 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 335 FILLLACGSVQSG-MFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMgWGFG 413
Cdd:COG2271 259 ALALLLLALLPSPaLAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA-TGYQ 337
|
410 420
....*....|....*....|
gi 2543671686 414 AVIAILAVPATLAALIIVFI 433
Cdd:COG2271 338 AAFLLLAALALLAALLALLL 357
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
26-433 |
7.69e-40 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 147.06 E-value: 7.69e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 26 LILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLA 105
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 106 CAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLP----EHGWRsVL 181
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppEIAWR-VL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 182 MVGGAIPLCCLPFYLWLVPESARFMVVRHYPAqriartlarvcggsfAADQTFSVSEppvksgqpakvLLSDSYRKTTLs 261
Cdd:cd17371 160 FLLGALPALLVLFIRRFVKEPPQWQAARAARR---------------HFADRPSLRE-----------LFSPPLLRTTL- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 262 LWGTYFMGLLVIYL-LSGWLPTLIKDA-GLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLL 339
Cdd:cd17371 213 LASLLATGALGGYYgITTWLPSYLTGErGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLY 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 340 ACGSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMgWGFGAVIAIL 419
Cdd:cd17371 293 FFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATS-GSLGTAIAVF 371
|
410
....*....|....
gi 2543671686 420 AVPATLAALIIVFI 433
Cdd:cd17371 372 AAVYYIAGLVLALL 385
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
26-431 |
6.80e-37 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 138.12 E-value: 6.80e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 26 LILCFLIVATDGMDVAIMGFLAPAITKE--WGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCS 103
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 104 LACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLP----EHGWRS 179
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 180 VLMVGGAIPLCCLPFylwlvpesarfmvvrhypaqriartlarvcggsfaadqtfsvseppvksgqpakvllsdsyRKTT 259
Cdd:cd17316 161 LFLIGALPALLALLL-------------------------------------------------------------RRRT 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 260 LSLWGTYFMGLLVIYLLSGWLPTLIK-DAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILL 338
Cdd:cd17316 180 LLLILLWFFISFGYYGLTTFLPTYLQtVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALP 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 339 LACGSVQSG-MFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAVIA 417
Cdd:cd17316 260 LFYLLSGSPtLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPAL 339
|
410
....*....|....
gi 2543671686 418 ILAVPATLAALIIV 431
Cdd:cd17316 340 ILALLAIVALIVAL 353
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-443 |
1.62e-32 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 126.92 E-value: 1.62e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 20 GYQWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWF 99
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 100 GVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRS 179
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 180 VLMVGGAIPLCCLPFYLWLVPESARFMVVRHYPAQRIARTLARvcggsfaadqtfsvseppvksgqpakvllsdsyRKTT 259
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALR---------------------------------DPRF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 260 LSLWGTYFMGLLVIYLLSGWLPTLIKDA-GLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILL 338
Cdd:COG2223 208 WLLSLLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 339 LACGSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAVIAI 418
Cdd:COG2223 288 LALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLV 367
|
410 420
....*....|....*....|....*
gi 2543671686 419 LAVPATLAALIIVFIQMGQRPAAAV 443
Cdd:COG2223 368 FAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-397 |
6.48e-32 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 124.32 E-value: 6.48e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 19 SGYQWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAW 98
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 99 FGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWR 178
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 179 SVLMVGGAIPLCCLPFYLWLVPESarfmvvrhypaqriartlarvcggsfaadqtfsvsePPVKSGQPAKVLLSDSYRKT 258
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPES------------------------------------RPAARARLRGSLRELLRRPR 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 259 TLSLWGTYFMGLLVIYLLSGWLPTLIKD-AGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFIL 337
Cdd:COG2814 209 LLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 338 LLACGSVQSGMFAAyVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSIL 397
Cdd:COG2814 289 LLALAGSLWLLLLA-LFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-399 |
1.42e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 106.73 E-value: 1.42e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 28 LCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACA 107
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 108 FAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVGGAI 187
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 188 PLCCLPFYLWLVPESARfmvvrhypaqriartlarvcggsfaadqtfSVSEPPVKSGQPAKVLLSDSYRKTTLSLWGTYF 267
Cdd:pfam07690 161 SLLAAVLLLLPRPPPES------------------------------KRPKPAEEARLSLIVAWKALLRDPVLWLLLALL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 268 MGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAV--FILLLACGSVQ 345
Cdd:pfam07690 211 LFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILaaLGLLLLSLTLS 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 2543671686 346 SGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGS 399
Cdd:pfam07690 291 SLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
23-433 |
1.06e-24 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 104.57 E-value: 1.06e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 23 WLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVC 102
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 103 SLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLM 182
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 183 VGGAIPLCCLPFYLWLVPesarfmvvrhypaqriartlarvcggsfaadqtfsvseppvksgqpakvllsdsyrkTTLSL 262
Cdd:cd17319 162 IEGLLGLLLAVLWWFYLR---------------------------------------------------------QVWGL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 263 WGTYFMGLLVIYLLSGWLPTLIKDA-GLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLAC 341
Cdd:cd17319 185 ALGYFGINYALYGLLTWLPTYLKQArGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 342 GSVQSGMFAAYVLL--AGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAVIAIL 419
Cdd:cd17319 265 AYLTTSPVVAVILLslAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFL 344
|
410
....*....|....
gi 2543671686 420 AVPATLAALIIVFI 433
Cdd:cd17319 345 AAVALLAALLVLLL 358
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
10-433 |
9.26e-23 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 99.56 E-value: 9.26e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 10 RSHINGRKMSGYQWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRK 89
Cdd:COG2807 4 TSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 90 KLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERsRSTLLAIMFTGFNLGSGLVGFLAA 169
Cdd:COG2807 84 RTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 170 ALLPEHGWRSVLMVGGAIPLCCLPFYLWLVPESARfmvvrhypaqriartlarvcggsfaadqtfsvSEPPVKSGQPAKV 249
Cdd:COG2807 163 PLAAALGWRGALAVWALLALLALLLWLPLLRRRPA--------------------------------AAAAAPAAASLRS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 250 LLSdsyRKTTLSLWGTYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAY 329
Cdd:COG2807 211 LWR---SPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 330 IAGAVfILLLACGSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVS-WMLGVGRFGSILGSFAGGVLLSM 408
Cdd:COG2807 288 GLLGL-AGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSgMAQSVGYLLAALGPLLVGALHDA 366
|
410 420
....*....|....*....|....*
gi 2543671686 409 GWGFGAVIAILAVPATLAALIIVFI 433
Cdd:COG2807 367 TGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
23-432 |
3.21e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 97.62 E-value: 3.21e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 23 WLLLILCFLIVATDGMDVAIMgflaPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVC 102
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLL----PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 103 SLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLM 182
Cdd:cd17324 78 NLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 183 VGGAIPLCCLPFYLWLVPESARFMVVRHYPAQRIARTLarvcggsfaadqtfsvseppvksgqpakvllsdsyrkTTLSL 262
Cdd:cd17324 158 AIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLL-------------------------------------RNPRL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 263 WGTYFMGLLVIYLLSGW----LPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILL 338
Cdd:cd17324 201 RLAYLITFLLFGGFFALytylAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 339 LACGSVQSGMFAAyVLLAGFCMSGAQTGLNAFAPSCYPTvVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAVIAI 418
Cdd:cd17324 281 TLLGPSPLLLLVG-LVLWGLGFFAAHSALQTRVLRLAPE-ARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVG 358
|
410
....*....|....
gi 2543671686 419 LAvpATLAALIIVF 432
Cdd:cd17324 359 AA--LLLLALLLAL 370
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-431 |
1.66e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 95.57 E-value: 1.66e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 30 FLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFA 109
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 110 HDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALL--PEHGWRSVLMVGGAI 187
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 188 PLCCLPFYLWLVPEsarfmvvrhypaqriartlarvcggsfaADQTFSVSEPPVKSGQPAKVLLSDSYRKTTLSLWGTYF 267
Cdd:cd06174 162 ALLAAILLLLVVPD----------------------------PPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIF 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 268 MGLLVIYLLSGWLPT-LIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLACGSVQS 346
Cdd:cd06174 214 LVNLAYYSFSTLLPLfLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 347 GMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAVIAILAVPATLA 426
Cdd:cd06174 294 LLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLA 373
|
....*
gi 2543671686 427 ALIIV 431
Cdd:cd06174 374 AILLL 378
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
22-230 |
1.53e-20 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 91.41 E-value: 1.53e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 22 QWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGV 101
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 102 CSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVL 181
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 2543671686 182 MVGGAIPLCCLpFYLWLVPESARFMVVRHYPAQRIARTLARVCGGSFAA 230
Cdd:COG0477 172 LINAPLGLLAL-VLRLRLPESRGLLLALLALALAALLLAALALALLALL 219
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
22-433 |
6.23e-19 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 88.10 E-value: 6.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 22 QWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGV 101
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 102 CSLACAFAHDVVTLSALRLLTGLGLGAAMPN-ATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRS- 179
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAvAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTa 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 180 VLMVGGAIPLCCLPFYLWLVPESARfmvvrhypaqriartlarvcggsfaadqTFSVSEPPVKSGQPAKVLLSDSYRKTT 259
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRPAD----------------------------LALRAYDDASPASPGSTLKEALRSASF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 260 LSLWGTYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLL 339
Cdd:cd17355 213 WLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 340 ACGSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAVIAIL 419
Cdd:cd17355 293 LLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALA 372
|
410
....*....|....
gi 2543671686 420 AVPATLAALIIVFI 433
Cdd:cd17355 373 VALGLIAALLVLPI 386
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
29-433 |
9.31e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 84.55 E-value: 9.31e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 29 CFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAF 108
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 109 AHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVGGAIP 188
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 189 LCCLPFYLWLVPESARFMVVRHYPAQRIARTLARVcggsfaadqtfsvseppvksgqpakvllsdSYRKTTLSLWGTYFM 268
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLL------------------------------LRDRRLLALFLAIFV 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 269 GLLVIYLLSGWLPTLIKD-AGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLACGSVQSG 347
Cdd:cd17325 211 LAFAFGALEPFLPLYAAElGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 348 MFAAYVLLaGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMgWGFGAVIAILAVPATLAA 427
Cdd:cd17325 291 LLLLLALL-GLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA-FGFATPFLAAAALLLLAA 368
|
....*.
gi 2543671686 428 LIIVFI 433
Cdd:cd17325 369 VLFLLL 374
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
16-443 |
1.25e-17 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 84.75 E-value: 1.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 16 RKMSGYQWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTA 95
Cdd:PRK03893 12 RHLNRAQWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVIS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 96 VAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEH 175
Cdd:PRK03893 92 IVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVW 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 176 GWRSVLMVGgaipLCCLPFYLWL---VPESA------------RFMVVRHYPAQR--IARTLARVCGGSFAADQTFSVSE 238
Cdd:PRK03893 172 GWRALFFIG----ILPIIFALWLrknLPEAEdwkekhagkapvRTMVDILYRGEHriINILLTLAAAAALWFCFAGNLQN 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 239 PPVKS--GQPAKVLLSDSYRKTTLSLWGTYFMGLLVIYL--LSGW-----LPTLIK-DAGLPIEKAASITALFQLGGTVG 308
Cdd:PRK03893 248 AAIVAvlGLLCAAIFISFMVQSSGKRWPTGVMLMVVVLFafLYSWpiqalLPTYLKtDLGYDPHTVANVLFFSGFGAAVG 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 309 ALVVGFLMDRWSPSRAIAAAYIAGAVFIL-LLACGSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWM 387
Cdd:PRK03893 328 CCVGGFLGDWLGTRKAYVCSLLISQLLIIpVFAIGGANVWVLGLLLFFQQMLGQGISGLLPKLIGGYFDTEQRAAGLGFT 407
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 2543671686 388 LGVGRFGSILGSFAGGVLLSmGWGFGAVIAILAVPATLAALIIVFIQMGQRPAAAV 443
Cdd:PRK03893 408 YNVGALGGALAPILGALIAQ-RLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWL 462
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
47-425 |
4.96e-17 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 83.14 E-value: 4.96e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 47 APAITKEWGI---SRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTG 123
Cdd:TIGR00898 112 SSTIVTEWDLvceDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVG 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 124 LGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPehgWRsVLMVGGAIPLCCLPFYLWLVPESA 203
Cdd:TIGR00898 192 MGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD---WR-WLQLAVSLPTFLFFLLSWFVPESP 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 204 RFMVVRHYP--AQRIARTLARVCGGSFAADQTFSVSEPPVKSGQPAKVLLSD----SYRKTTLSLWGTYFMGLLVIYLLS 277
Cdd:TIGR00898 268 RWLISQGRIeeALKILQRIAKINGKKLPAEVLSLSLEKDLSSSKKQYSFLDLfrtpNLRKTTLCLMMLWFTTAFSYYGLV 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 278 GWLPTLikdaGLPIEKAASITALFQLggtvGALVVGFLMDRWSPSRA--IAAAYIAGAVFILLLACGSVQSGMFAAYVLL 355
Cdd:TIGR00898 348 LDLGNL----GGNIYLDLFISGLVEL----PAKLITLLLIDRLGRRYtmAASLLLAGVALLLLLFVPVDLYFLRTALAVL 419
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2543671686 356 AGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILG---SFAGGVLLSMGWGFGAVIAILAVPATL 425
Cdd:TIGR00898 420 GKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISpflVYLGEKWLFLPLVLFGGLALLAGILTL 492
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
37-213 |
6.37e-16 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 79.15 E-value: 6.37e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 37 GMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLS 116
Cdd:cd17359 14 GYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 117 ALRLLTGLGLGAAMPNATTLLSEYVPERSRSTL-----LAI---MFTGFNLGSGLVGFLAAALLPEHGWRSVLmVGGAIP 188
Cdd:cd17359 94 IARIIGGLAVGGASALVPMYIAEVAPAEIRGRLvslnqLMIvfgQLLAYIVNYLIANAGGADWLGAEGWRWML-GLEAIP 172
|
170 180
....*....|....*....|....*
gi 2543671686 189 LCCLPFYLWLVPESARFMVVRHYPA 213
Cdd:cd17359 173 AILFLLGMLFIPESPRWLVSKGKPI 197
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
23-442 |
1.51e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 74.89 E-value: 1.51e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 23 WLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVC 102
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 103 SLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPErSRSTLLAIMFTGFNLGSGLVGFLAAALLPEH---GWRS 179
Cdd:COG0738 87 LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPE-TAASRLNLLHAFFSLGALLGPLLGGLLILLGlslSWHL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 180 VLMVGGAIPLC-CLPFYLWLVPEsarfmvvrhypaqriartlarvcggsfaadqtfsVSEPPVKSGQPAKVLLSDSYRKT 258
Cdd:COG0738 166 PYLILAVLLLLlALLFLRSKLPE----------------------------------IEEEEEEAAGSAASLKSLLKNPR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 259 TLSLWGTYFMGLLVIYLLSGWLPTLIKDA-GLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFIL 337
Cdd:COG0738 212 LLLGGLAIFLYVGAEGAIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 338 LLACGSVQSGMFAAyVLLAGFCMSGAQTGLNAFAPSCYPTvVRATGVSWMLGVGRFGSILGSFAGGVLLSMgwgFGAVIA 417
Cdd:COG0738 292 LALLAPGPWLALIG-LALVGLGLSLMFPTIFSLALDGLGK-RTAAAVSAVLIMGIVGGAIGPPLIGFLADA---FGLRAA 366
|
410 420
....*....|....*....|....*
gi 2543671686 418 iLAVPATLAALIIVFIQMGQRPAAA 442
Cdd:COG0738 367 -FLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
38-187 |
1.37e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 71.82 E-value: 1.37e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 38 MDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSA 117
Cdd:cd17321 10 LDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIA 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 118 LRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVGGAI 187
Cdd:cd17321 90 ARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
27-205 |
6.06e-13 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 69.84 E-value: 6.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 27 ILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLAC 106
Cdd:cd17441 2 ILTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 107 AFAhDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSvLMVGGA 186
Cdd:cd17441 82 AFA-PIYSWILVLRGLVGFGIGGVPQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRW-LLILSA 159
|
170
....*....|....*....
gi 2543671686 187 IPLCCLPFYLWLVPESARF 205
Cdd:cd17441 160 LPLLIFAVLCFWLPESARY 178
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
27-211 |
1.24e-12 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 68.74 E-value: 1.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 27 ILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLAC 106
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 107 --AFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVG 184
Cdd:cd17380 82 plLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFF 161
|
170 180
....*....|....*....|....*..
gi 2543671686 185 GAIPLCCLPFYLWLVPeSARFMVVRHY 211
Cdd:cd17380 162 GLLGLLWALVWLIYLP-PVWAIIVAHF 187
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-199 |
1.59e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 68.76 E-value: 1.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 15 GRKMSGYQWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMT 94
Cdd:cd17325 191 GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 95 AVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPE 174
Cdd:cd17325 271 GLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA 350
|
170 180
....*....|....*....|....*
gi 2543671686 175 HGWRSVLMVGGAIPLCCLPFYLWLV 199
Cdd:cd17325 351 FGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
21-317 |
2.65e-12 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 68.85 E-value: 2.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 21 YQWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFG 100
Cdd:TIGR01299 164 FQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNG 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 101 VCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRsv 180
Cdd:TIGR01299 244 FFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGWS-- 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 181 LMVGGA---------IPLCCLP-----FYLWLVPESARFM--VVRHYPA----QRIARTLARVCGgsfAADQTFSVSEpp 240
Cdd:TIGR01299 322 FQMGSAyqfhswrvfVIVCAFPcvfaiGALTFMPESPRFFleNGKHDEAwmilKLIHDTNMRAKG---HPEKVFSVNH-- 396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 241 VKSGQPAKVLL---SDS-----------------------------YRKTTLSLWGTYFMGLLVIYLLSGWLPTLIKDag 288
Cdd:TIGR01299 397 IKTIHQEDELIeieSDTgtwyqrcfvralsegggiwgnflrcfnpeVREITIKLMGVWFTLSFGYYGLSVWFPDMIKH-- 474
|
330 340
....*....|....*....|....*....
gi 2543671686 289 LPIEKAASITALFQlGGTVGALVVGFLMD 317
Cdd:TIGR01299 475 LQADDYAALTKNFP-GDKVAHFSFNFTLE 502
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
23-204 |
2.69e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 67.97 E-value: 2.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 23 WLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGR--KKLLMTAVAWFG 100
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 101 VCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSV 180
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|....
gi 2543671686 181 LMVGGAIPLCCLPFYLWLVPESAR 204
Cdd:COG2271 340 FLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
23-433 |
2.71e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 67.98 E-value: 2.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 23 WLLLILCFLIVatdgMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVC 102
Cdd:cd17474 2 YAVFFATLLAV----LGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 103 SLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTllAIMFTGFNLGSGLVGF-LAAALLPEHGWRSVL 181
Cdd:cd17474 78 GLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAK--AMGLYEAALGLGIAVGpLLGGLLAAISWRYPF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 182 MVGGAIPLCCLPFYLWLVPEsarfmvvrhypaqriartlarvcggsfaadqtfsvsEPPVKSGQPAKVLLSDSYRKTTLS 261
Cdd:cd17474 156 FLLAALIPVAFLAILFLLPE------------------------------------PKEKAKSSSATKLRDLKKALRGRG 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 262 LWGTYFMGLLVIYLLSG---WLPTLIKD-AGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFIL 337
Cdd:cd17474 200 LLTFLVSAFLYFFLYFAfltYLPFLLELlYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 338 LLACGSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGvLLSMGWGFGAVIA 417
Cdd:cd17474 280 LLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFG-LLLEIFGLSAPFL 358
|
410
....*....|....*.
gi 2543671686 418 ILAVpATLAALIIVFI 433
Cdd:cd17474 359 VGAA-IALAAAVLLAL 373
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
36-407 |
2.81e-12 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 67.94 E-value: 2.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 36 DGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTL 115
Cdd:cd17372 11 EAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 116 sALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVGGAIPLCCLPFY 195
Cdd:cd17372 91 -IILRCLVGLGLGGGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLVFY 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 196 LWLVPESARFMVV------RHYPAQRIARTLAR---VCGGSFAADQTFSVSEPPVKSGQPAkvllsdSYRKTTLSlwgty 266
Cdd:cd17372 170 RWTPKTTLLLWVIwfgnafAYYGVVLLTTELNNshnVCGSKSDSDSGESPTEKQCRNSNDV------DYRDVFIA----- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 267 fmgllviyllsgwlpTLIKDAGLPIEkaasitalfqlggtvgALVVGFLMDRWSPSraiAAAYIAGAVFILLLACGSvqS 346
Cdd:cd17372 239 ---------------TFAEFPGLLIS----------------AAMIDRLGRKASMA---SMLFTCCIFLLLLLICQS--P 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2543671686 347 GMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLS 407
Cdd:cd17372 283 FILTVLLFGGRACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLVH 343
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
44-430 |
4.50e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 67.26 E-value: 4.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 44 GFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTG 123
Cdd:cd17475 16 PALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 124 LGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGsglvGFLAAALLPE----HGWRSVLMVGGAIP-LCCLPFYLWL 198
Cdd:cd17475 96 AGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLG----GALAAALLPPlalhYGWRAAFVVAGLVSiLAAVLFWLFY 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 199 VPESArfmvvrhypaqriartlarvcggsfaadqtfSVSEPPVKSGQPAKVLLSDSYRKTTLSLWGTYFMGLLVIYLLSG 278
Cdd:cd17475 172 REPPA-------------------------------ASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTF 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 279 WLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLACGSVQSGMFAAYVLLAGF 358
Cdd:cd17475 221 LLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLL 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2543671686 359 CMSGAqtGLNAFAPSCYPTVVRATGVSW-------MLGVGRFGSILGSFAGGVLLSMGWGFGAVIAILAVPATLAALII 430
Cdd:cd17475 301 ILLGL--FAIGWNGLYLTLVAESAGPEQagtalglANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
30-412 |
7.24e-12 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 66.63 E-value: 7.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 30 FLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFA 109
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 110 HDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEH-GWRSVLMVGGAIp 188
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGII- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 189 lcCLPFYLWLvpesarFMVVRHYPAQRIARTLARVCGGSFAADQTFSVSEPPVKSGQPAKVLLSDsyrkttlSLWGTYFM 268
Cdd:TIGR00881 160 --AIIVSLIC------FLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNK-------VLWYISLG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 269 GLLVIYLLSG---WLPT-LIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDR-WSPSRAIAAAYIAGAVFILLLACGS 343
Cdd:TIGR00881 225 YVFVYVVRTGildWSPLyLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKlFNGRRGPLAVFFMALIIVSLLVYWL 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2543671686 344 VQSG---MFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWmlgVGRFGSILGSFAGGVL--LSMGWGF 412
Cdd:TIGR00881 305 NPAAnplMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGF---VGFFAYLGGILAGLPLgyLADGFGW 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
62-434 |
8.50e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 66.44 E-value: 8.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 62 GVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYV 141
Cdd:cd17473 38 PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYF 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 142 PERSRSTLLAIMfTGFNLGSGLVGFLAAALLPEHGWRSVLMVgGAIPLCCLPFYLWLVPesarfmvvrhypaqriartla 221
Cdd:cd17473 118 EGEERAKMLGLQ-SAAMSLGGVVFLLLGGALAEIGWRAPFLV-YLLALPVLILVLLFLP--------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 222 rvcggsfaadqtfsvsEPPVKSGQPAKVLLSDSYRKTTLSLWGTYFMGLLVI---YLLSGWLPTLIKDAGLPIEKAASIT 298
Cdd:cd17473 175 ----------------EPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMllfYVIPIQLPFLLQERGGGSAALIGLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 299 -ALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLACGSVQSGMFAAyVLLAGFCMSGAQTGLNAFAPSCYPT 377
Cdd:cd17473 239 lAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLG-AILAGLGFGLLLPTLNSWAMSLVPP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2543671686 378 VVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAVIAILAVPATLAALIIVFIQ 434
Cdd:cd17473 318 ELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
36-429 |
4.64e-11 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 64.18 E-value: 4.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 36 DGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTL 115
Cdd:PRK12307 30 DGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIML 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 116 SALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVgGAIPLCCLPFY 195
Cdd:PRK12307 110 TLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFV-GLLPVLLVIYI 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 196 LWLVPESARFMVvrhypaqriartlARVCGGSFAADQTFSVSEPPVKSgqpakvllsdSYRKTTLSLWGTYFMGLLVIY- 274
Cdd:PRK12307 189 RARAPESKEWEE-------------AKLSGKGKHSQSAWSVFSLSMKG----------LFNRAQFPLTLCVFIVLFSIFg 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 275 ---LLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLACGSVQSGmfaa 351
Cdd:PRK12307 246 anwPIFGLLPTYLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDNY---- 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 352 yvLLAGFCMSG---AQTGLNAFAPSC----YPTVVR--ATGVSWMLGV--GRFGSILGSFAGGvllSMGWGFGAVIAILA 420
Cdd:PRK12307 322 --LLLGACLFGlmaTNVGVGGLVPKFlydyFPLEVRglGTGLIYNLAAtsGTFNSMAATWLGI---TMGLGAALTFIVAF 396
|
....*....
gi 2543671686 421 VPATLAALI 429
Cdd:PRK12307 397 WTATILLII 405
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
26-405 |
1.22e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.02 E-value: 1.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 26 LILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLA 105
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 106 CAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGL---VGFLAAALLPehGWRSVLM 182
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLgyvVGGLVAQATG--GWRWAFR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 183 VGGAIPLCCLPFYLWLVPESARfmvvrhypaqriartlarvcggsFAADQTFSVSEPPVKSGQPAKVLLSD-SYRKTTLS 261
Cdd:cd17328 159 VTGVLGVLLAILLLLFVREPPR-----------------------GAAEGGVMAKSTATSFLADLKALAKNpSFILSTLG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 262 LWGTYFmgllVIYLLSGWLPTLIKDAGLPIEKAASITALF-----QLGGTVGALVVGFLMDRWSPSR-----AIAAAYIA 331
Cdd:cd17328 216 FTAVSF----VTGALAFWAPTFFLRAFGVGDLSSADVGLIfgaitCIAGVLGVLLGGILADRLRRKTpradpLVCAVGLL 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2543671686 332 GAVFILLLACGSVQSGMFAAYVLLAG--FCMSGAQTGLNAFAPSCYPTVVRATGVSW-MLGVGRFGSILGSFAGGVL 405
Cdd:cd17328 292 AAAPFLFLALVLALSNLLLAWVLLFLgeFLLSLNWAPVFAILLYVVIPTRRSTASAIqILLSHLLGDAGSPYLIGLI 368
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
23-433 |
1.28e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.00 E-value: 1.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 23 WLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSD----RYGRKKLLMTAVAW 98
Cdd:COG2211 10 KEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 99 -FGVCSLACAFAHD------VVTLSALRLLTGLGLGAAMPNATTLLSEYVPE-RSRSTLLAIMFTGFNLGSGLVGFLAAA 170
Cdd:COG2211 90 pLALSFVLLFTAPDlsptgkLIYALVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 171 LL------PEHGWRSVLMVGGAIPLCCLPFYLWLVPESARfmvvrhypaqriartlarvcggsfaadqtfsVSEPPVKSG 244
Cdd:COG2211 170 LVaafggdAALGYRLTALIFAVLGLLAFLLTFFGTKERPV-------------------------------PEEEKVSLK 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 245 QPAKVLLSDsyrKTTLSLWGTYFMGLLVIYLLSGWLPTLIKDA-GLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSR 323
Cdd:COG2211 219 ESLKALLKN---RPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKK 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 324 AIAAAYIAGAV-FILLLACGSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSC-----YPTVVRATGV--SWMLGVGRFGS 395
Cdd:COG2211 296 AFIIGLLLAALgLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydeWKTGRRREGLyfGIFTFAIKLGQ 375
|
410 420 430
....*....|....*....|....*....|....*...
gi 2543671686 396 ILGSFAGGVLLSMgwgFGAVIAILAVPATLAALIIVFI 433
Cdd:COG2211 376 ALAGALAGLLLAL---FGYVAGAAQSPSALTGIRLLFF 410
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
43-429 |
2.20e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 61.81 E-value: 2.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 43 MGFLAPAIT---KEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALR 119
Cdd:cd17477 12 SGLLLPLLSlrlEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 120 LLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLvGFLAAALLPEHGWRSVLMVGGAIPLCCLPFYLwlv 199
Cdd:cd17477 92 FVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFAL-GPLLLALVGTAGALPFLIAAVLLLLALVPLLL--- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 200 pesarfmvvrhypaqriartlarvcggsfaadqtfsVSEPPVKSGQPAKVLLSDSYRKTTLSLWGTYFMGLLVIYLLSGw 279
Cdd:cd17477 168 ------------------------------------TRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSL- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 280 LPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLACGSVQSGMFAAYVLLAGFC 359
Cdd:cd17477 211 LPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGA 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 360 MSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAVIAILAVPATLAALI 429
Cdd:cd17477 291 AGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
22-198 |
2.60e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.86 E-value: 2.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 22 QWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGV 101
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 102 CSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVL 181
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
170
....*....|....*..
gi 2543671686 182 MVGGAIPLCCLPFYLWL 198
Cdd:cd06173 367 LLAGALLLLAALLLLLL 383
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
23-217 |
4.04e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 61.09 E-value: 4.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 23 WLLLILCFLIVATDGMdvaIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVC 102
Cdd:cd17329 2 WVLLIGSFLNRLGFFM---VWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 103 SLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGsGLVGFLAAALLPEHGWRSVLM 182
Cdd:cd17329 79 FALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLG-VAIGPLLGGLLLLYSFRLLFL 157
|
170 180 190
....*....|....*....|....*....|....*
gi 2543671686 183 VGGAIPLCCLPFYLWLVPESARFMVVRHYPAQRIA 217
Cdd:cd17329 158 AAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRG 192
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
31-285 |
5.81e-10 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 61.09 E-value: 5.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 31 LIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAH 110
Cdd:cd17438 6 LALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 111 DVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWR------------ 178
Cdd:cd17438 86 GYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGWGfsmgtnyhfhsw 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 179 SVLMVGGAIPLCCLPFYLWLVPESARFM--VVRHYPAQRIartLARVCGGSFAAdqtfsvseppvkSGQPAKVL-LSDSY 255
Cdd:cd17438 166 RVFVIICALPCIASIIALKFMPESPRFLleMGKHDEAWMI---LKNIHDTNMRA------------KGTPEKVFtVSNIK 230
|
250 260 270
....*....|....*....|....*....|
gi 2543671686 256 RKTTLSLWGTYFMGLLVIYLLSGWLPTLIK 285
Cdd:cd17438 231 RKNTLFLAVVWFTMAFSYYGLTVWFPDMIR 260
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
31-431 |
1.59e-09 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 59.81 E-value: 1.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 31 LIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAH 110
Cdd:cd17363 6 LALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 111 DVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRsvLMVGGA---- 186
Cdd:cd17363 86 GYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHYGWG--FSMGTAyqfh 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 187 -----IPLCCLPFYLWLV-----PESARFM--VVRHYPAQRIartLARVCGGSFAAdqtfsvseppvkSGQPAKVL-LSD 253
Cdd:cd17363 164 swrvfVIVCALPSVASVValtfmPESPRFLleVGKHDEAWMI---LKQVHDTNMRA------------KGHPERVFtVSH 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 254 SYRKTTLSLWGTYFMGLLVIYLLSGWLPTLIKDAGLP--------IEKAASITALFQ---LGGTV--------------- 307
Cdd:cd17363 229 IKRMNTLFLAIVWFTMSFSYYGLTVWFPDMIKYLQFEdslfeecyFEDVTSTNTFFEnctFINTVfyntdlfeykfidsr 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 308 ---------------------------------------GALVVGFLMDRWSPSRAIAAAYIAGAVFILLLACGSVQSGM 348
Cdd:cd17363 309 flnstfflkekcgchlnddeenayliylvsflgslsvlpGNIVSALLMDKIGRLKMIGGSMLLSAVCCFFLFFGNSESAM 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 349 FAAYVLLAGFCMSgAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAggvllsmgwgFGAVIAIL-AVPATLAA 427
Cdd:cd17363 389 IGLQCLFCGVSIA-AWNALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSI----------FGSFVGITkVIPILLAS 457
|
....
gi 2543671686 428 LIIV 431
Cdd:cd17363 458 AALV 461
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
19-202 |
1.92e-09 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 58.93 E-value: 1.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 19 SGYQWLLLILCFLIVATDGMDVAIMGFlaPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAW 98
Cdd:TIGR00710 2 SAKAFALLLGCLSILGPLGIDMYLPAF--PEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 99 FGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWR 178
Cdd:TIGR00710 80 FALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWH 159
|
170 180
....*....|....*....|....
gi 2543671686 179 SVLMVGGAIPLCCLPFYLWLVPES 202
Cdd:TIGR00710 160 AIFAFLSLAGILLSALIFFILPET 183
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
70-432 |
1.93e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 58.75 E-value: 1.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 70 IGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRStl 149
Cdd:cd17317 36 LGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRS-- 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 150 LAIMFTGFNLGSGLVGFLAAALLPEHgWRSvLMVGGAIPLCCLPFYLWLVPesarfmvvrhypaqriartlarvcggsfa 229
Cdd:cd17317 114 FVGILFGLFWALGYMLLALLAYLIRD-WRW-LQLAISLPGLLFLLLLWWLP----------------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 230 adqtfsvseppvksgqpakvllsdsyrKTTLSLWGTYFMGLLVIYLLSGWLPTLikdaglpiekAASITALFQLGGTV-- 307
Cdd:cd17317 163 ---------------------------RRTIIVGLIWFVTSLVYYGLSLNSSNL----------GGNLYLNFFLSGLVei 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 308 -GALVVGFLMDRWSPSRAIAAAYIAGAVFILLLACGSVQSGMFAAYVLLAG-FCMSGAQTGLNAFAPSCYPTVVRATGVS 385
Cdd:cd17317 206 pAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGkFAISAAFSVIYLYTAELYPTVVRNTGVG 285
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 2543671686 386 WMLGVGRFGSILGSFAggVLLSMGWGFGAVIaILAVPATLAALIIVF 432
Cdd:cd17317 286 LCSTVARVGAILAPFI--VLLGKIGPLLPLI-IFGVLALLGGLLTLL 329
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
31-285 |
2.79e-09 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 58.89 E-value: 2.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 31 LIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAH 110
Cdd:cd17439 6 LALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 111 DVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWR------------ 178
Cdd:cd17439 86 GYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSfqmgsayqfhsw 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 179 SVLMVGGAIPLCCLPFYLWLVPESARFMVV--RHYPAQRIartLARVCGGSFAAdqtfsvseppvkSGQPAKVL-LSDSY 255
Cdd:cd17439 166 RVFVLVCAFPSVFAIGALTTMPESPRFFLEngKHDEAWMV---LKQVHDTNMRA------------KGHPERVFsVTHIK 230
|
250 260 270
....*....|....*....|....*....|
gi 2543671686 256 RKTTLSLWGTYFMGLLVIYLLSGWLPTLIK 285
Cdd:cd17439 231 RRITLMMMAVWFTMSFSYYGLTVWFPDMIK 260
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
256-432 |
8.31e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.91 E-value: 8.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 256 RKTTLSLWGTYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVF 335
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 336 ILLLACgSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMgWGFGAV 415
Cdd:COG2814 89 SLLCAL-APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL-FGWRWV 166
|
170
....*....|....*..
gi 2543671686 416 IAILAVPATLAALIIVF 432
Cdd:COG2814 167 FLVNAVLALLALLLLLR 183
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
37-432 |
1.21e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 56.56 E-value: 1.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 37 GMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLS 116
Cdd:cd17333 9 GLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 117 ALRLLTGLGLGAAMPNATTLLSEYVPErSRSTLLAIMFTGFNLGSGLVGFLAAALL-PEHGWRSVLMVGGAIplCCLPFY 195
Cdd:cd17333 89 VLMFLAGLGAGILDTGANTFVGALFEE-SSATRLNVLHGFFGLGALIGPLIATSLLtSELSWSWAYLIIGLI--YLLLAI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 196 LWLVPESarfmvvrhypaqriartlarvcggsfaaDQTFSVSEPPVKSGQPAKVLLSDSYRKTTLSLWGTYFMGLLVIYL 275
Cdd:cd17333 166 LILLTLF----------------------------PELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 276 LSGWLPTLIKDAGLPIEKAAS-ITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLACGSVQSGMFAAYVL 354
Cdd:cd17333 218 FSSWVPSYLVEKKHVSDGLAGyLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATAL 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2543671686 355 LaGFCMSGAQTGLNAFAPSCYPtVVRATGVSWMLGVGRFGSILGSFAGGVLLSmgwgFGAVIAILAVPATLAALIIVF 432
Cdd:cd17333 298 L-GLFMAALFPTILSLGISNLP-YAKGKGTSVLLAAGSIGGAIIPFIMGFIAE----AVGIQTAMLLITILYAIIFVL 369
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
37-207 |
1.44e-08 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 56.43 E-value: 1.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 37 GMDVAIMGFLAPAITKEWGISRAAF--GVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVT 114
Cdd:cd17315 10 GYDLGVINGALLYIAKDLGFGLSTSlqGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 115 LSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAI--MFTGFNLGSGLVGFLAAALLPEHGWRsvLMVGGAIPLCCL 192
Cdd:cd17315 90 LIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLnqLMITFGILLAYLLGLALSLSPPGWWR--LMFALAAVPALL 167
|
170
....*....|....*.
gi 2543671686 193 PFYLWLV-PESARFMV 207
Cdd:cd17315 168 QLLLMFFlPESRALLV 183
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
62-432 |
1.92e-08 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 56.12 E-value: 1.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 62 GVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWF---GVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLS 138
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLvvsSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQ 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 139 EYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALL--PEHGWRsVLMVGGAIP--LCCLPfyLWLVPESARFMVVRHYPAQ 214
Cdd:cd17357 132 EISPSELRGALGSLTQIGVTLGILLGQVFGLPSVlgTETLWP-YLLFFPGIPalLQLAA--LPFFPESPKFLLISKGDEE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 215 RIARTLARVCGGSFAADQTF------SVSEPPVKSGQPAKVLLSDSYRKTTLS----LWGTYFMGLLVIYLLSgwlPTLI 284
Cdd:cd17357 209 EAEKSLKFLRGIEDDVDQELeeikkeSEQMGDQKQVSLMQLLRDPSLRLPLLLvlvvSASQQFSGINAIFFYS---TFIF 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 285 KDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLACG--SVQSGMFAAYVLLAGFCMSG 362
Cdd:cd17357 286 ENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFlfLSEQNSWMSYGCIVAIFLFI 365
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2543671686 363 A--QTGLNafaPSCY-------PTVVRATGVSWMLGVGRFGSILGSFAggVLLSMGWGFGAVIAILAVPATLAALIIVF 432
Cdd:cd17357 366 FffAIGLG---PIPWfigaelfPQAPRSAAQSLGSSVNWTSNFIVGMA--FPPLQSIGGGFVFIIFAIPCALFLLYLYR 439
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
25-201 |
3.92e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 54.89 E-value: 3.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 25 LLILCFLIVATdGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSL 104
Cdd:cd17323 1 VFIISFLTFVV-TFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 105 ACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVG 184
Cdd:cd17323 80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159
|
170
....*....|....*..
gi 2543671686 185 GAIPLCCLPFYLWLVPE 201
Cdd:cd17323 160 AIISGFCLILIFLFLPI 176
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
35-433 |
8.58e-08 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 53.82 E-value: 8.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 35 TDGMDVAIMGFLAPAITKEWGI-----SRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFA 109
Cdd:cd17364 10 TDAYDLFSISLVTKILGRLYYGgkgslPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 110 HDVVTLSALRLLTGLGLGAAM------PNATTLLSEYVPERSRSTLLAIMFT--GFNLGSGLVGFLAAALLPEH------ 175
Cdd:cd17364 90 PGSTPLGVMGWLIFFRFLLGIgiggdyPLSATIMSEYANKKRRGALIAAVFAmqGFGILAGAIVTLILSAIFEHplpagt 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 176 ------GWRSVLMVGGAIPLCCLPFylwlvpesarfmvvrhypaqriARTLARVCGGSFAADQTFSvseppvksgqpakv 249
Cdd:cd17364 170 yhhadlVWRIVLGLGAIPALSVLYF----------------------RKHLLGTAGTWFLLDIAFY-------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 250 llsdsyrktTLSLWGTyfmgllVIYLLSGWLPTLIKDAGLpIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAY 329
Cdd:cd17364 214 ---------GQNLFQS------TIISAIGFSKTMNAYQEL-FNIAVGQLIIALAGTVPGYWFTVFLIDRIGRKKIQMMGF 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 330 IAGAVFILLLAC-----GSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGV 404
Cdd:cd17364 278 FGMTIFLLILAGpydhwKISTIGFFVLYGLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLS 357
|
410 420
....*....|....*....|....*....
gi 2543671686 405 LLSMgWGFGAVIAILAVPATLAALIIVFI 433
Cdd:cd17364 358 LTQN-IGVRNVLIILAGVALLGIILTLLF 385
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
31-285 |
1.35e-07 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 53.76 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 31 LIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAH 110
Cdd:cd17440 6 MALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 111 DVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWR------------ 178
Cdd:cd17440 86 GYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSfsmgsayqfhsw 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 179 SVLMVGGAIPLCCLPFYLWLVPESARFM--VVRHYPAQRIartLARVCGGSFAAdqtfsvseppvkSGQPAKVLLSDSYR 256
Cdd:cd17440 166 RVFVIVCALPCVSSVVALTFMPESPRFLleVGKHDEAWMI---LKQIHDTNMRA------------RGQPEKVFTVNRIK 230
|
250 260 270
....*....|....*....|....*....|
gi 2543671686 257 K-TTLSLWGTYFMGLLVIYLLSGWLPTLIK 285
Cdd:cd17440 231 KdNTIKLTIVWLTLSFGYYGLSVWFPDVIK 260
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
62-433 |
1.77e-07 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 53.04 E-value: 1.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 62 GVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLG---LGAAMPNATTLLS 138
Cdd:pfam00083 49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVgigVGGASVLAPMYIS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 139 EYVPERSRSTLLAIMFTGFNLGsGLVGFLAAALL----PEHGWRsvLMVGGAIPLCCLPFYLWL-VPESARFMVV--RHY 211
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAITFG-ILLAYIFGLGLnktsNSDGWR--IPLGLQLVPALLLIIGLLfLPESPRWLVEkgRLE 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 212 PAQRIARTLARVCGGSFAADQTFS----VSEPPVKSGQPAKVLLSDSYRKTTLSL--WGTYFMGLLVIYLLSgwlPTLIK 285
Cdd:pfam00083 206 EAREVLAKLRGVPDVDRELDEIKDsleaGQEAEKASWKELFSTKTRRQRLLIGVMlqIFQQLTGINAIFYYS---TTIFE 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 286 DAGLPieKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLACGS---VQSGMFAAYVLLAGFCMSG 362
Cdd:pfam00083 283 NLGLS--DSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFVILGIVAllgVSKSDWAGIVAIVFIALFI 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 363 AqTGLNAFAPSCY-------PTVVRATGvswmLGVGRFGSILGSFAGGVLL-----SMGWGF-GAVIAILAVpatlAALI 429
Cdd:pfam00083 361 A-FFAMGWGPVPWvivselfPLSVRSKA----MALATAANWLANFLIGFLFpiitdAIGLGYtFFIFAGLLV----LFII 431
|
....
gi 2543671686 430 IVFI 433
Cdd:pfam00083 432 FVFF 435
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
254-435 |
2.25e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 52.55 E-value: 2.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 254 SYRKTTLSLWGTYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGA 333
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 334 VFILLLACgSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTvVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFG 413
Cdd:COG0738 85 LGLLLFAL-APSYPLLLLALFLLGLGLGLLDVAANPYVAALGPE-TAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLS 162
|
170 180
....*....|....*....|....
gi 2543671686 414 --AVIAILAVPATLAALIIVFIQM 435
Cdd:COG0738 163 whLPYLILAVLLLLLALLFLRSKL 186
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
26-115 |
2.88e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 52.19 E-value: 2.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 26 LILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLA 105
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90
....*....|
gi 2543671686 106 CAFAHDVVTL 115
Cdd:cd17320 81 CALASSIEQL 90
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
62-200 |
5.38e-07 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 51.47 E-value: 5.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 62 GVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFA--HDVVTLSALRLLTGLGLGAAMPNATTLLSE 139
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAarGGYGALIVLRILQGLAQGVTFPAMHALWAK 138
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2543671686 140 YVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVGGAIPLCCLPFYLWLVP 200
Cdd:cd17318 139 WAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL 199
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
63-210 |
6.48e-07 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 51.12 E-value: 6.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 63 VVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVP 142
Cdd:cd17360 39 LIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAP 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2543671686 143 ERSRSTLLAI---MFTGFNLGSGLVGFLAAALlpEHGWRSVLMVGGAIPLCCLPFYLWLvPESARFMVVRH 210
Cdd:cd17360 119 PRIRGRLVTInvlFITGGQFVAYVINGAFSYL--PGGWRWMLGLAAVPAVLQFIGLLFL-PESPRWPSTRR 186
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
22-431 |
8.12e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 50.74 E-value: 8.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 22 QWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGV 101
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 102 CSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVL 181
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 182 MVGGAIPLCCLPFYLWLVPESARFMVVrhypaqriartlarvcggsfaadqtfsvseppvksgqpakvllsdsyrkttLS 261
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSPPYVWV---------------------------------------------------LS 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 262 LwgTYFMGLLVIYLLSGWLPTLIKD-AGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRaiaaaYIAGAVFILLLA 340
Cdd:cd17312 190 L--AYAFVYIVRYACLDWGPLYLYEvKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGR-----RAPIAVIYMLLM 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 341 CGSVQSGMF--------AAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMlgVGRFGSILGSFAGGVL--LSMGW 410
Cdd:cd17312 263 TLSLALFWFfphnkllsIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAAGTATGF--VGLFGYLGASLAGLPLgyIIDHY 340
|
410 420
....*....|....*....|.
gi 2543671686 411 GFGAVIAILAVPATLAALIIV 431
Cdd:cd17312 341 GWSTVFYFLISAALLSVLLLL 361
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
70-200 |
9.31e-07 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 50.37 E-value: 9.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 70 IGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRStl 149
Cdd:cd17374 46 AGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRA-- 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2543671686 150 LAIMFTG--FNLGSGLVGFLAAALlpeHGWRsVLMVGGAIPLCCLPFYLWLVP 200
Cdd:cd17374 124 LAITLTScfFSIGQMLLAGLAYAI---RDWR-LLQLVVSVPFFLFFLYSWWLP 172
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
37-180 |
1.20e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 50.25 E-value: 1.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 37 GMDVAIMGFLAPAITKEWGiSRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLS 116
Cdd:cd17502 9 ALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLI 87
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2543671686 117 ALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSV 180
Cdd:cd17502 88 VGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWC 151
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
262-432 |
1.71e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.72 E-value: 1.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 262 LWGTYFMGLLVIYLLSGWLPTLIKDA-GLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLA 340
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 341 CGSvQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMgWGFGAVIAILA 420
Cdd:pfam07690 81 FAS-SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL-FGWRAAFLILA 158
|
170
....*....|..
gi 2543671686 421 VPATLAALIIVF 432
Cdd:pfam07690 159 ILSLLAAVLLLL 170
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
45-318 |
1.76e-06 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 50.03 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 45 FLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGL 124
Cdd:cd17343 24 FVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 125 GLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVGGAIPLCCLPFYlwlvpesar 204
Cdd:cd17343 104 AQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVC--------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 205 FMVVRHYPaqriartlarvcggsfaADQTFSVSEPPVKSGQPAKVLLSDSYRKTTLSLwgTYFMGLLVIYLLSGWLPT-- 282
Cdd:cd17343 175 LLFIKNEP-----------------SDVGLNNIEEEESKGKKKKSPRGESTLKELLLS--PFLWLLSLGYLVVFGVKTav 235
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 2543671686 283 -------LIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDR 318
Cdd:cd17343 236 tdwgqlfLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDW 278
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
57-433 |
1.77e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.92 E-value: 1.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 57 SRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAA-----MP 131
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIasaffGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 132 NATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVGGAIPLCCLPFYLWLvpesarfmvvrHY 211
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFI-----------RR 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 212 PAQRIARTLARVCGGSFAADQTFSVSEPPVKSGqpakvllsdsyrKTTLSLWGTYFMGLLVIyllsgwLPTLIKDA-GLP 290
Cdd:cd06173 181 PPPAAPGESSSLLLRDLREGLRYLRRSPLLRLL------------LLALALFALLGGALTVL------LPLLAKEVlGGG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 291 IEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLAcGSVQSGMFAAYVLLAGFCMSGAQTGLNAF 370
Cdd:cd06173 243 AAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLG-LSPSLWLLLAALFLLGLAGGLFNVPLNTL 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2543671686 371 APSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMgWGFGAVIAILAVPATLAALIIVFI 433
Cdd:cd06173 322 LQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA-LGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
22-172 |
3.04e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.13 E-value: 3.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 22 QWLLLILCFLIVATdGMDVaIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGV 101
Cdd:COG2211 229 PFLLLLLAYLLFFL-ALAL-VAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 102 CSLACAFA--HDVVTLSALRLLTGLGLGAAMPNATTLLSEYVP-------ERSRSTLLAIMFTGFNLGSGLVGFLAAALL 172
Cdd:COG2211 307 GLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
48-431 |
3.36e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.09 E-value: 3.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 48 PAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLG 127
Cdd:cd17478 20 PLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 128 AAMPNATTLLSEYVPERsRSTLLAIMFTGFNLGSGLvGFLAAALLPEHGWRSVLMVGGAIPLCCLPFYLWLVPESARFMV 207
Cdd:cd17478 100 AFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFAL-GPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 208 VRHYPAQRIARTLARVcggsfaadqtfsvseppvksgqpakvllsdsyRKTTLSLWGTYFMGLLVIYLLSGWLPTLIKDA 287
Cdd:cd17478 178 KKAAAKSSARSTLKGV--------------------------------WRALLLLLIIVFLRSWVLSSLTTFLPFYLVQR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 288 GLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLAcgSVQSGMFAAYVLLAGFCMSGAQTGL 367
Cdd:cd17478 226 GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFL--LTPGIWSYILLVLAGFLLFASFPVT 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2543671686 368 NAFAPSCYPTVVR-ATGVSWMLGVGrFGSILGSFAGGVLLSmgWGFGAVIAILAVPATLAALIIV 431
Cdd:cd17478 304 VVLAQELLPGNVGlASGLMMGLSFG-LGGIGAPVLGALADA--FGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
48-187 |
3.39e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 48.73 E-value: 3.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 48 PAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLsALRLLTGLGLG 127
Cdd:cd17504 20 PTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVL-IAGRALQGIGG 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2543671686 128 AAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGlVGFLAAALLPEH-GWRSVLMVGGAI 187
Cdd:cd17504 99 AVFPLAFALVREEFPPERVPVAQGILSATFGIGAG-IGLPLGGWIVQHlGWRWIFWTAAPV 158
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
48-112 |
3.50e-06 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 49.17 E-value: 3.50e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2543671686 48 PAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDV 112
Cdd:PRK15402 37 LAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSI 101
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
43-207 |
3.94e-06 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 48.73 E-value: 3.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 43 MGFLAPAITK-------EWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTL 115
Cdd:cd17358 18 VGWSSPALPSlmsdnslSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWML 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 116 SALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSgLVGFLAAALLPehgWRSVLMVGGAIPLCCLPFy 195
Cdd:cd17358 98 YLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGI-LLGYVLGSFLP---WRTLALIGAIPPVVFLIL- 172
|
170
....*....|..
gi 2543671686 196 LWLVPESARFMV 207
Cdd:cd17358 173 LFFIPESPRWLA 184
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
59-199 |
5.95e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.97 E-value: 5.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 59 AAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLS 138
Cdd:cd17489 227 SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAV 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2543671686 139 EYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVGGAIPLCCLPFYLWLV 199
Cdd:cd17489 307 DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
42-198 |
7.91e-06 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 47.98 E-value: 7.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 42 IMGFLAPAITKEWGISRAAFGVVMSAAPI-GLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRL 120
Cdd:cd17331 226 FQSMFSLVAMDFFGLTPEENGYLMSYAGVlGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLL 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2543671686 121 LTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVGGAIPLcCLPFYLWL 198
Cdd:cd17331 306 PLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAING-LLTVYLLL 382
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
48-112 |
9.15e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 47.60 E-value: 9.15e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2543671686 48 PAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDV 112
Cdd:PRK11102 15 PVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTI 79
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
43-115 |
9.69e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 47.58 E-value: 9.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 43 MGFLA-----PA---ITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVT 114
Cdd:PRK11043 17 LGFLAtdmylPAfkaIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQ 96
|
.
gi 2543671686 115 L 115
Cdd:PRK11043 97 L 97
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
70-399 |
9.79e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 47.63 E-value: 9.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 70 IGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTL 149
Cdd:cd17327 52 VGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKR 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 150 LAIMFTGFNLGSGLVGFLAAALLPEH------GWRSVLMVGGAIPLCCLPFYLWLVP---ESARFMVVRHypaQRIARtl 220
Cdd:cd17327 132 IAFFYAAAGLGSIFGGLLAYGVFKILgvgglaGWRWLFIIEGLITIIIGLVIFFWLPdnpSKAWFLTEEE---KELAV-- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 221 ARVcggsfAADQTfSVSEPPVKSGQPAKVLLsdSYRKTTLSLWgtYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITAL 300
Cdd:cd17327 207 ERL-----RANQT-GKGDQKFKWKQIKEAFK--DPRTWLLFLF--FFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVP 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 301 FQLGGTVGALVVGFLMDRWsPSRAIAAAYIAGAV---FILLLACGSVQSGMFAAYVLLAGFCMSGAQTGLNAFApSCYPT 377
Cdd:cd17327 277 IGALGAVSLLIAALLSDRF-KKRGLFAIFACVLAlvgSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISS-NCAGY 354
|
330 340
....*....|....*....|..
gi 2543671686 378 VVRATGVSWMLGVGRFGSILGS 399
Cdd:cd17327 355 TKRATVLAIMLIFYNVGNIVAP 376
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
23-196 |
1.09e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 47.42 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 23 WLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRY-GRKKLLMTAVAWFGV 101
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 102 CSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPE-HGWRSV 180
Cdd:cd06174 283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGA 362
|
170
....*....|....*.
gi 2543671686 181 LMVGGAIPLCCLPFYL 196
Cdd:cd06174 363 FLVLAVLLLLAAILLL 378
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
48-432 |
1.20e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.20 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 48 PAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLG 127
Cdd:cd17489 20 PLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 128 AAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVGGAIPLCCLpFYLWLVPEsarfmv 207
Cdd:cd17489 100 AFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLAL-LLVFLVKD------ 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 208 vrhypaqriartlarvcggsfaadqtfsVSEPPVKSGQPAKVLLSDSYRKTTLSlwgtYFMGLLVIYLLSGWLPTLIKDA 287
Cdd:cd17489 173 ----------------------------PPPVAAEEAEAGTRAFRRLVEKKVLP----PALILFLASIAYGAISTFLPLY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 288 G--LPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLACGSVQSGMFAAYVLLaGFCMSGAQT 365
Cdd:cd17489 221 AaeRGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLY-GLGFGLLFP 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2543671686 366 GLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMgWGFGAVIAILAVPATLAALIIVF 432
Cdd:cd17489 300 ALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAEL-FGYRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
24-178 |
1.35e-05 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 47.11 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 24 LLLILCFLIVAtDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCS 103
Cdd:cd17442 2 LFLIMGSTGVA-EAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFS 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2543671686 104 LACAFAHDVVTLsALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWR 178
Cdd:cd17442 81 LLTSFAPSYIWF-VFLRCMVGCGVSGHSQGLIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWR 154
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
22-189 |
2.83e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.00 E-value: 2.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 22 QWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGV 101
Cdd:cd17324 197 NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 102 CSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPErSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVL 181
Cdd:cd17324 277 LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE-ARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVG 355
|
....*...
gi 2543671686 182 MVGGAIPL 189
Cdd:cd17324 356 WVGAALLL 363
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
25-200 |
3.04e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 45.72 E-value: 3.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 25 LLILCFLIVATDGMDVAIMGFLAPAItkewGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSL 104
Cdd:cd17476 3 ISGAQLLNQAGLGSVIVILPIIGDSF----GTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 105 ACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSE-YVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVL-M 182
Cdd:cd17476 79 IAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRtYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFwF 158
|
170
....*....|....*...
gi 2543671686 183 VGGAIPLCCLPFYLWLVP 200
Cdd:cd17476 159 LAILAAIVAVAAIFWTSP 176
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
74-429 |
3.77e-05 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 45.75 E-value: 3.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 74 IGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAA--------MPNATTLLSEYVPERS 145
Cdd:cd17367 55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATIGIWAPIILLLARLLqglsvggeYGTSATYLSEVAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 146 RS--------TLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVGGAIPLcclpFYLWL---VPESARFMvvrhypaq 214
Cdd:cd17367 135 RGfyssfqyvTLIGGQLLALGVLLVLQHTLGEDQMAAWGWRIPFLLGGVLAV----VVLWLrrgLEETESFE-------- 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 215 riartlarvcggsfaadqtfSVSEPPVKSGQPAKVLLsdSYRKTTLSLWGTYFMGLLVIYLLSGWLPT-LIKDAGLPIEK 293
Cdd:cd17367 203 --------------------AIAESNEASAGTLRELR--RHPRELLLVVGLTAGGTLAFYTWTTYLQKfLVNTAGFSKGD 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 294 AASITALFQLGGTVGALVVGFLMDRW--SPSRAIAAAYIAGAVFILLLACGSVQSGMFAAYVLLAGFCMSGAQTGLNA-F 370
Cdd:cd17367 261 ATWITTAALLVFMLLQPLGGRLSDRIgrRPLLLFFGIGGTLATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTSINAvV 340
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2543671686 371 APSCYPTVVRATGVSwmLGVGRFGSILGSFAGGVLLSMG-----WGFGAVIAILAVPATLAALI 429
Cdd:cd17367 341 KAELFPTHVRALGVG--LPYALAVAIFGGTAPYVALWLKsigheWVFFWYVAGLIAISLVVYLR 402
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
38-152 |
4.03e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 45.64 E-value: 4.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 38 MDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSA 117
Cdd:cd17503 10 LDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLII 89
|
90 100 110
....*....|....*....|....*....|....*
gi 2543671686 118 LRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAI 152
Cdd:cd17503 90 FRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGL 124
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
70-202 |
4.76e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 43.02 E-value: 4.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 70 IGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTL 149
Cdd:TIGR00880 9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVA 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2543671686 150 LAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVGGAIPLCCLPFYLWLVPES 202
Cdd:TIGR00880 89 LGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
262-433 |
5.68e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.11 E-value: 5.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 262 LWGTYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLAc 341
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 342 GSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSM-GWGFGAVIAILA 420
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlGFGWRAVFLIAA 159
|
170
....*....|...
gi 2543671686 421 VPATLAALIIVFI 433
Cdd:cd06174 160 ALALLAAILLLLV 172
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
22-200 |
6.61e-05 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 45.10 E-value: 6.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 22 QWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGV 101
Cdd:PRK14995 4 QWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 102 CSLACAFAHDVVTLSALRLLTGLGLGAAMPnATT--LLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRS 179
Cdd:PRK14995 84 ASLAAAFSPTASWLIATRALLAIGAAMIVP-ATLagIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGS 162
|
170 180
....*....|....*....|.
gi 2543671686 180 VLMVGGAIPLCCLPFYLWLVP 200
Cdd:PRK14995 163 VFLINVPIVLVVMGLTARYVP 183
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
62-183 |
7.35e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.56 E-value: 7.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 62 GVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYV 141
Cdd:cd17391 243 GLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKIT 322
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 2543671686 142 PERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMV 183
Cdd:cd17391 323 PKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVV 364
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
18-189 |
8.04e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.51 E-value: 8.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 18 MSGYQWLLLILCFLIVATDGMDVAIMGFLAPAITKEW-GISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAV 96
Cdd:cd17316 171 LALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 97 AWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNAT--TLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPE 174
Cdd:cd17316 251 ILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGAlyAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS 330
|
170
....*....|....*
gi 2543671686 175 HGWRSVLMVGGAIPL 189
Cdd:cd17316 331 TGGTGVPALILALLA 345
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
21-192 |
8.24e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 44.52 E-value: 8.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 21 YQWLLLILCFLIVATDGMdvAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFG 100
Cdd:cd17353 213 PTFWLLWLMFFLNATAGL--MLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQG 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 101 VCSLACAFA-HDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRS 179
Cdd:cd17353 291 VAMFLLPFIgSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNA 370
|
170
....*....|...
gi 2543671686 180 VLMVGGAIPLCCL 192
Cdd:cd17353 371 AFIIAAALSLVAL 383
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
30-432 |
9.00e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 44.49 E-value: 9.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 30 FLIVATDGMDVAIMGFLAPAITKEWGISRAA---FGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLAC 106
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVREFNKLGASgyyVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 107 AFAHDVVTLsALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVLMVGGA 186
Cdd:cd17330 82 GLSRNLWLL-FLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 187 IPLCCLPFYLWLVPESARFMVVRHYpaqriartlarvcggSFAADQTFSVSEPpvksgqpakVLLSDSYRkttlslWGTY 266
Cdd:cd17330 161 LALLNLVLVLFFLPPLRRLLLVYFL---------------IALAFAGLESVFS---------LFLKDRFG------FSPS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 267 FMGLLVIYllsgwlptlikdaglpiekAASITALFQLggtvgaLVVGFLMDRWSPSRAIAAAYIAGAVFILLLACGSVQS 346
Cdd:cd17330 211 QIGLLLAL-------------------VGIAGILAQL------LLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVP 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 347 GMFAAYVLLAgFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMgWGFGAVIAILAVPATLA 426
Cdd:cd17330 266 LLVLAAAILA-FGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSF-LGPGVPFLLAAGLLLIA 343
|
....*.
gi 2543671686 427 ALIIVF 432
Cdd:cd17330 344 LFLLSL 349
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
22-366 |
9.82e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.55 E-value: 9.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 22 QWLLLILCFLIVAtdgmdvaIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGV 101
Cdd:cd17341 4 SWLSFFLGFMVWF-------LFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 102 CSLACAFAH----DVVTLSALRLLTGLGLGAAMPNAttllSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAAL------ 171
Cdd:cd17341 77 PLLALALAVssywGLLVLGFLLGFAGANFASGQPWA----SFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIagaivf 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 172 -LPEHGWRSVlmvggaiplcclpFYLWLVPESarfmvvrhypaqriartLARVCGGSFAADQTFSVSEPPVKSGQPAKVL 250
Cdd:cd17341 153 dGGFVGWRNA-------------FFVPGILLA-----------------IAAVLVLLFGDDLPTGKASALEFLKVQLAVL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 251 LSdsYRKTTLSLWGTYFMGLLVIYllSGWLPTLIKDA-GLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAY 329
Cdd:cd17341 203 KN--YRTWILSLLYGVTFGSFVGF--SNVLPTYFKTRfGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLF 278
|
330 340 350
....*....|....*....|....*....|....*...
gi 2543671686 330 IAGAVFILLLAC-GSVQSGMFAAYVLLAGFCMSGAQTG 366
Cdd:cd17341 279 IVMTIGAALLSLsLPTSGTNLVLFLALFVALGLGAGAG 316
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
23-433 |
1.31e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 44.14 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 23 WLLLILCFLIVATDGMdVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVC 102
Cdd:cd17353 3 WLVLLGAVLMHLILGY-QYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 103 SLACAFAHDVVT--LSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMftGFNLGSGLVGFLAAALLPEHGWRSV 180
Cdd:cd17353 82 FILSAFAISLPLlfLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIA--GFGLGSLIFSPLIAYLINTVGVPTT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 181 LMVGGAIPLCCLPFYLWLVpesaRFMVVRHYPAQRIARTLARvcggsfaadqtfsvsEPPVKSGQPAKVLLSdsyrKTTL 260
Cdd:cd17353 160 FLILGIIFLIIIVIGAFLI----RDPPKGWVPPGVDPLANNA---------------ENSPRDYTPREMLRT----PTFW 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 261 SLWGTYFMGLLVIYLLSGWLPTLIKD-AGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLL 339
Cdd:cd17353 217 LLWLMFFLNATAGLMLIGQAKPIGQEfAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 340 ACGSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMgWGFGAVIAIL 419
Cdd:cd17353 297 PFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYT-GGYNAAFIIA 375
|
410
....*....|....
gi 2543671686 420 AVPATLAALIIVFI 433
Cdd:cd17353 376 AALSLVALALALLL 389
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
70-200 |
2.00e-04 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 43.11 E-value: 2.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 70 IGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTL 149
Cdd:cd17379 44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTV 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2543671686 150 LAIMFTGFNLGSGLVGFLAAALlpeHGWRSVLMVgGAIPLCCLPFYLWLVP 200
Cdd:cd17379 124 GIVYQMFFTLGLLILPGIAYFI---PHWRWLQLA-VTLPNFLFLLYYWFIP 170
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
26-399 |
2.29e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.38 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 26 LILCFLIVATDGMDVAImGFLAPAITKEWGiSRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLA 105
Cdd:cd06179 1 AALCLAYFAQLFGVTLP-AAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 106 CAFAHDVVTLsALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEH--GWRSV--- 180
Cdd:cd06179 79 AGTAKSVNML-IGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIfyi 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 181 LMVGGAIPLCCLPFYLWLVPESARFMVVRHYPAQRI------------------------------ARTLARVCGGsFAA 230
Cdd:cd06179 158 NAIFNALALILLFFFYHPPPRPQLHGSSTRQKLKRLdwvglflliaglvlfllglswggnpypwssAHVIAPLVIG-GVL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 231 DQTFSVSEPPVKSGQPAKVLLSDSYRKTTLSLWGTYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGAL 310
Cdd:cd06179 237 LIAFGLYEWKGTKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAI 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 311 VVGFLMDRWSPSRAI-AAAYIAGAVFILLLA-CGSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYP-----------T 377
Cdd:cd06179 317 LAGLLLTKIKHIKWQlVAGFVLFTAFLALLAlITPDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPpedigtasgllG 396
|
410 420
....*....|....*....|..
gi 2543671686 378 VVRATGVSwmLGVGRFGSILGS 399
Cdd:cd06179 397 SARALGGA--VGTAIFTSILSN 416
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
257-318 |
4.21e-04 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 42.18 E-value: 4.21e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2543671686 257 KTTLSLWGTYFMGL--LVIYLLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDR 318
Cdd:cd17339 194 RSPLAWQVTLFMGLqsLLFYTLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLLVPILATR 257
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
51-205 |
4.69e-04 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 42.34 E-value: 4.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 51 TKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAM 130
Cdd:cd17362 31 TDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAM 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2543671686 131 PNATTLLSEYVPERSRSTLLAiMFTGFNLGSGLVGFLAAALLPE--HGWRsvLMVGGAIPLCC-LPFYLWLVPESARF 205
Cdd:cd17362 111 HAAPVYIAETSPSHIRGLLVS-LKELFIVLGILLGYVSGYAFADvvGGWR--YMYGLAAPPALlLGIGMWFLPPSPRW 185
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
23-433 |
5.11e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 42.15 E-value: 5.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 23 WLLLILCFLI-VATDGMDVAImGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGV 101
Cdd:cd17352 2 WVVVFASFLVnFFTDGILNSF-GVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 102 CSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPEHGWRSVL 181
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 182 MVGGAIPLCCLPFylwlvpesARFMVVRHYPAQRIartlarvcggsfaadqtfsvseppvksgqpakvllsdsyrkttLS 261
Cdd:cd17352 161 LILGGLCLNLCVC--------GLLLRLLKDPTFVL-------------------------------------------LA 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 262 LWGTYFMglLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLAC 341
Cdd:cd17352 190 LGVSFAM--LGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAF 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 342 GSVQS-GMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAVIAILA 420
Cdd:cd17352 268 PLATTyVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCG 347
|
410
....*....|...
gi 2543671686 421 VPATLAALIIVFI 433
Cdd:cd17352 348 ACLLLSGVLLFLL 360
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
10-196 |
8.29e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.37 E-value: 8.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 10 RSHINGRKMSGYQWLLLILCFLIVATDgMDVAIMGFLApaitKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRK 89
Cdd:cd17370 190 SKKTSLKKLPKAFWLYLLAVALFALGN-FSFAFLILRA----QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRK 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 90 KLLMTAVAWFGVCSLACAFAHDVVTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAA 169
Cdd:cd17370 265 KLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAG 344
|
170 180
....*....|....*....|....*..
gi 2543671686 170 ALLPEHGWRSVLMVGGAIPLCCLPFYL 196
Cdd:cd17370 345 YLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
46-431 |
1.09e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 41.07 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 46 LAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAhDVVTLSALRLLTGLG 125
Cdd:cd17345 25 AQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFV-PSATSSVGLMFILLF 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 126 LGAAM-----PNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVG---FLAAALLPEHGWRSVLMVGGAIPLCCLPFYLW 197
Cdd:cd17345 104 LNGWFqgmgwPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGplaGLGLAIFGDGWWRGAFIFPAIIAIIVAVIVLF 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 198 LV---PESARFMVVRHYPAQRIARTLARvcggsfAADQTFSVSEPPVKSGQPAKVllsdsyrkttlsLWGTYFMGLLVIY 274
Cdd:cd17345 184 LGkdtPESEGLPPIEEYKGDYPEEADGE------EEEQELSAWEIFVKYVLKNKL------------LWYIAIANVFVYL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 275 LLSG---WLPT-LIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLACGSVQSGMFA 350
Cdd:cd17345 246 VRYGildWAPTyLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALIVYWLAPNVLV 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 351 AYVLLA--GFCMSGAQT--GLNA--FAPScyptvvRATGVSWMLgVGRFGSILGSFAGGVLLSM-----GWGFGAVIAIL 419
Cdd:cd17345 326 DLIALIalGFLIYGPVMliGLQAleLVPK------KAAGTAAGL-TGLFGYLGGSVLATALIGIivdhfGWNGGFIVLLA 398
|
410
....*....|..
gi 2543671686 420 AVPATLAALIIV 431
Cdd:cd17345 399 SCILAIIFLALV 410
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
59-429 |
1.58e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.59 E-value: 1.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 59 AAFGVVMSAAPIGlaigALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHD--------VVTLSALRLLTGLGLGAAM 130
Cdd:cd17369 48 ATFGVGFLARPLG----GVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTyaqigilaPILLVLLRLLQGLALGGEW 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 131 PNATTLLSEYVPERSRSTLLAIMFTGFNLG---SGLVGFLAAALLPEH-----GWR-----SVLMVGGAiplcclpfylw 197
Cdd:cd17369 124 GGAVLMAVEHAPPKRRGFYGSFPQLGAPVGlllATGVFLLLSALLSDEaflswGWRipfllSAVLVAVG----------- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 198 lvpesarfMVVRhypaqriartlarvcggsfaadqtFSVSEPPV-----KSGQPAKVLLSD---SYRKTTLSLWGTYFMG 269
Cdd:cd17369 193 --------LYIR------------------------LRLEETPVfrrakEAGQVVRAPLVEvlrRHWRALLLAIGLRLAE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 270 LLVIYLLSGWLPT-LIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLAcGSVQSGM 348
Cdd:cd17369 241 NVLFYLFTTFALSyATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFF-WLLDTGS 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 349 FAAYVLLAGFCMSGAQTGLN----AFAPSCYPTVVRATGVS--WMLGVGRFGSILGSFAGGVLLSMG--WGFGAVIAILA 420
Cdd:cd17369 320 TWLIVLAAVVVLGVLHGMMYgpqaAFLAELFPTRVRYTGASlgYQLGAILGGGFAPLIATALVAATGswWPVALYLAALA 399
|
....*....
gi 2543671686 421 VPATLAALI 429
Cdd:cd17369 400 VISLVAALF 408
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
62-202 |
1.96e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 40.29 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 62 GVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLsALRLLTGLGLGAAMPNATTLLSEYV 141
Cdd:PRK09874 57 GLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQF-LILRALLGLLGGFVPNANALIATQV 135
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2543671686 142 PERSRSTLLAIMFTGfNLGSGLVGFLAAALLPEH-GWRSVLMVGGAIPLCCLPFYLWLVPES 202
Cdd:PRK09874 136 PRNKSGWALGTLSTG-GVSGALLGPLAGGLLADSyGLRPVFFITASVLFLCFLVTLFCIREN 196
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
259-433 |
2.45e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.84 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 259 TLSLWGTYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPsRAIAAAYIAGAVFILL 338
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIER-RRLLLVLLLLFILGNL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 339 LACGSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGvLLSMGWGFGAVIAI 418
Cdd:cd17324 80 LAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGG-LLGQLLGWRAAFLA 158
|
170
....*....|....*
gi 2543671686 419 LAVPATLAALIIVFI 433
Cdd:cd17324 159 IAVLALLAALLLWRL 173
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
41-160 |
2.62e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 2.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 41 AIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLSALRL 120
Cdd:cd17473 215 VIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAI 294
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2543671686 121 LTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLG 160
Cdd:cd17473 295 LAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLG 334
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
37-210 |
2.63e-03 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 39.69 E-value: 2.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 37 GMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSLACAFAHDVVTLS 116
Cdd:cd17437 10 GYDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 117 ALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGS--GLVGFLAAALLPEH-GWRsvLMVG-GAIPLCCL 192
Cdd:cd17437 90 VGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGIllGYVSNYAFSGLPLHvGWR--LMLGvGAVPSLFL 167
|
170
....*....|....*....
gi 2543671686 193 PFYLWLVPESARFM-VVRH 210
Cdd:cd17437 168 AIGVLAMPESPRWTpAVRR 186
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
18-192 |
2.84e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 39.82 E-value: 2.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 18 MSGYQWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVA 97
Cdd:cd17369 223 LRRHWRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGAL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 98 WFGVCSLACAFAHDV--VTLSALRLLTGLGLGAAMPNAT--TLLSEYVPERSRSTLLAImftGFNLGSGLVG----FLAA 169
Cdd:cd17369 303 LAALFAFPFFWLLDTgsTWLIVLAAVVVLGVLHGMMYGPqaAFLAELFPTRVRYTGASL---GYQLGAILGGgfapLIAT 379
|
170 180
....*....|....*....|....
gi 2543671686 170 ALLPEHG-WRSVLMVGGAIPLCCL 192
Cdd:cd17369 380 ALVAATGsWWPVALYLAALAVISL 403
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
256-433 |
3.44e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.41 E-value: 3.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 256 RKTTLSLWGTYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVF 335
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 336 ILLLACgSVQSGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMgWGFGAV 415
Cdd:COG0477 93 SLLCGL-APSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA-LGWRWI 170
|
170
....*....|....*...
gi 2543671686 416 IAILAVPATLAALIIVFI 433
Cdd:COG0477 171 FLINAPLGLLALVLRLRL 188
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
280-443 |
4.50e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 39.09 E-value: 4.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 280 LPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAVFILLLACGSVQSGMFAAYVlLAGFC 359
Cdd:COG2807 41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTA-LIGAG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 360 MSGAQTGLNAFAPSCYPT-VVRATGVsWMLGVGRFGSILGSFAGGVLLSMGWGFGavIAILAVPAtLAALIIVFIQMGQR 438
Cdd:COG2807 120 IAVGNVLLPGLIKRWFPDrVGLMTGL-YTAAMGLGAALAAGLTVPLAAALGWRGA--LAVWALLA-LLALLLWLPLLRRR 195
|
....*
gi 2543671686 439 PAAAV 443
Cdd:COG2807 196 PAAAA 200
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
60-168 |
6.38e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 38.51 E-value: 6.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 60 AFGVVMSAApIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCS----LACAFAHDVVTLSALRLLTGLGLGAAMPNATT 135
Cdd:cd17368 260 SFLVTLLAG-VANFIWAPLGGALSDRIGRRPVLLVITLAALVTLypvfAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVV 338
|
90 100 110
....*....|....*....|....*....|...
gi 2543671686 136 LLSEYVPERSRSTLLAIMftgFNLGSGLVGFLA 168
Cdd:cd17368 339 ALVELFPVRVRSTGFSLV---YALAVAIFGGFA 368
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
267-442 |
6.59e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.73 E-value: 6.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 267 FMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLGGTVGALVVGFLMDRWSPSRAIAAAYIAGAV-FILLLACGSVq 345
Cdd:cd17489 6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALaTLLYLLATSV- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 346 sGMFAAYVLLAGFCMSGAQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGgVLLSMGWGFGAVIAILAVPATL 425
Cdd:cd17489 85 -ALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALG-LFLYQHLGFAVLFIVAAVLALL 162
|
170
....*....|....*..
gi 2543671686 426 AALIIVFIQMGQRPAAA 442
Cdd:cd17489 163 ALLLVFLVKDPPPVAAE 179
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
25-110 |
7.32e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 38.35 E-value: 7.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 25 LLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMSAAPIGLAIGALLVGPLSDRYGRKKLLMTAVAWFGVCSL 104
Cdd:PRK11652 9 LLFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTL 88
|
....*.
gi 2543671686 105 ACAFAH 110
Cdd:PRK11652 89 VALFAH 94
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
34-196 |
9.11e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 38.11 E-value: 9.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 34 ATDGMDVAIMGFLAPAITKEWgISRAAFGVVMSAAPIGLA-------IGALLVGPLSDRYGRKKLL-----MTAVAWFGV 101
Cdd:cd17366 9 AMEWFDFGVYGYLAVTIGKVF-FPGGDPTAQLLATFATFAvaflvrpLGGLVFGPLGDKYGRQKVLaitiiLMAASTFCI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543671686 102 CSLACAFAHDV---VTLSALRLLTGLGLGAAMPNATTLLSEYVPERSRSTLLAIM----FTGFNLGSGLVGFLAAALLPE 174
Cdd:cd17366 88 GLLPTYATIGVwapILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLefgtLAGFILGAGLVTLLTLLLTEA 167
|
170 180
....*....|....*....|....*.
gi 2543671686 175 H----GWRSVLMVggAIPLCCLPFYL 196
Cdd:cd17366 168 QmldwGWRIPFLI--AAPLGLVGLYL 191
|
|
| |
