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Conserved domains on  [gi|2543673970|ref|WP_299541044|]
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TetR/AcrR family transcriptional regulator [uncultured Herbaspirillum sp.]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11095567)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  15808743|23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR_C_11 pfam16859
Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional ...
 60-162 3.99e-22

Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.


:

Pssm-ID: 435608  Cd Length: 113  Bit Score: 86.09  E-value: 3.99e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543673970  60 DSGSTRDDIEQHMLQLSQLLRG-KSGRVVREMIALAQFEQESRRIFNDNYLEPRRLALVNVLRRGAQRGEFREDADLNLV 138
Cdd:pfam16859   3 DTGSLRGDLRALLRALARALTSpRGGALLRALIAAAQRDPELAAALRERFLEPRRAALRAVLERAVARGELRPDADPDLV 82

                          90       100
                  ....*....|....*....|....
gi 2543673970 139 FDLLYAPVLQRLLTGSADIDERQI 162
Cdd:pfam16859  83 LDLLFGPLYYRLLLTGEPLDEAYA 106
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
2-52 7.18e-09

Bacterial regulatory proteins, tetR family;


:

Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 49.71  E-value: 7.18e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2543673970   2 LDATYVMLEEIGFDKLSLEGVAARAGVGKATIYRWWPNKsalamEALLRAV 52
Cdd:pfam00440   2 LDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSK-----EELLEAL 47
 
Name Accession Description Interval E-value
TetR_C_11 pfam16859
Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional ...
 60-162 3.99e-22

Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.


Pssm-ID: 435608  Cd Length: 113  Bit Score: 86.09  E-value: 3.99e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543673970  60 DSGSTRDDIEQHMLQLSQLLRG-KSGRVVREMIALAQFEQESRRIFNDNYLEPRRLALVNVLRRGAQRGEFREDADLNLV 138
Cdd:pfam16859   3 DTGSLRGDLRALLRALARALTSpRGGALLRALIAAAQRDPELAAALRERFLEPRRAALRAVLERAVARGELRPDADPDLV 82

                          90       100
                  ....*....|....*....|....
gi 2543673970 139 FDLLYAPVLQRLLTGSADIDERQI 162
Cdd:pfam16859  83 LDLLFGPLYYRLLLTGEPLDEAYA 106
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-144 9.29e-13

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 62.99  E-value: 9.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543673970   1 MLDATYVMLEEIGFDKLSLEGVAARAGVGKATIYRWWPNKSALAMEALLRAVEP----LPALGDSGSTRDDIEQHMLQLS 76
Cdd:COG1309    11 ILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEEllaaLEEALAAEDPRERLRALLRAYL 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2543673970  77 QLLRgKSGRVVREMIALAQFEQESRRIFNDNYLEPRRLalvnvLRRGAQRGEFREDADLNLVFDLLYA 144
Cdd:COG1309    91 EFLA-ENPALARLLLAEAAELPELRAALRALLRRLRAL-----LAELLRAGGLLADVDPDALARALLA 152
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
2-52 7.18e-09

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 49.71  E-value: 7.18e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2543673970   2 LDATYVMLEEIGFDKLSLEGVAARAGVGKATIYRWWPNKsalamEALLRAV 52
Cdd:pfam00440   2 LDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSK-----EELLEAL 47
 
Name Accession Description Interval E-value
TetR_C_11 pfam16859
Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional ...
 60-162 3.99e-22

Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.


Pssm-ID: 435608  Cd Length: 113  Bit Score: 86.09  E-value: 3.99e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543673970  60 DSGSTRDDIEQHMLQLSQLLRG-KSGRVVREMIALAQFEQESRRIFNDNYLEPRRLALVNVLRRGAQRGEFREDADLNLV 138
Cdd:pfam16859   3 DTGSLRGDLRALLRALARALTSpRGGALLRALIAAAQRDPELAAALRERFLEPRRAALRAVLERAVARGELRPDADPDLV 82

                          90       100
                  ....*....|....*....|....
gi 2543673970 139 FDLLYAPVLQRLLTGSADIDERQI 162
Cdd:pfam16859  83 LDLLFGPLYYRLLLTGEPLDEAYA 106
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-144 9.29e-13

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 62.99  E-value: 9.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543673970   1 MLDATYVMLEEIGFDKLSLEGVAARAGVGKATIYRWWPNKSALAMEALLRAVEP----LPALGDSGSTRDDIEQHMLQLS 76
Cdd:COG1309    11 ILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEEllaaLEEALAAEDPRERLRALLRAYL 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2543673970  77 QLLRgKSGRVVREMIALAQFEQESRRIFNDNYLEPRRLalvnvLRRGAQRGEFREDADLNLVFDLLYA 144
Cdd:COG1309    91 EFLA-ENPALARLLLAEAAELPELRAALRALLRRLRAL-----LAELLRAGGLLADVDPDALARALLA 152
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
2-52 7.18e-09

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 49.71  E-value: 7.18e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2543673970   2 LDATYVMLEEIGFDKLSLEGVAARAGVGKATIYRWWPNKsalamEALLRAV 52
Cdd:pfam00440   2 LDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSK-----EELLEAL 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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