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Conserved domains on  [gi|2544068990|ref|WP_299883378|]
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calcium-binding protein, partial [uncultured Sulfitobacter sp.]

Protein Classification

calcium-binding protein( domain architecture ID 11458495)

RTX toxin-related calcium-binding protein belongs to the serralysin-like M10 metalloprotease family, such as Bordetella pertussis adenylate cyclase toxin

CATH:  2.150.10.10|3.40.390.10
Gene Ontology:  GO:0005509
PubMed:  32860773|27058787|1558765
SCOP:  4002779|3001975

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 82-212 1.66e-09

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 57.99  E-value: 1.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544068990  82 GTHGDNTLNGTAAADAINGHGGDDAINGAGGDDFLQGGYGNDTLDGGAGNDVLDGGHGEDVLNGGDGDDLLISRADGREG 161
Cdd:COG2931   117 GGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTL 196

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2544068990 162 AIFYDPNRDEGDPYNELTNGKLYPDQPIPADDVMTGGAGADVFYIQTLINA 212
Cdd:COG2931   197 DGGGGDDTLGGGGGDDGLDGGDGDDGLGGGGGDDTLGGGGGGDGGGGGGGD 247
 
Name Accession Description Interval E-value
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 82-212 1.66e-09

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 57.99  E-value: 1.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544068990  82 GTHGDNTLNGTAAADAINGHGGDDAINGAGGDDFLQGGYGNDTLDGGAGNDVLDGGHGEDVLNGGDGDDLLISRADGREG 161
Cdd:COG2931   117 GGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTL 196

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2544068990 162 AIFYDPNRDEGDPYNELTNGKLYPDQPIPADDVMTGGAGADVFYIQTLINA 212
Cdd:COG2931   197 DGGGGDDTLGGGGGDDGLDGGDGDDGLGGGGGDDTLGGGGGGDGGGGGGGD 247
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
118-152 9.16e-06

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 42.04  E-value: 9.16e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2544068990 118 GGYGNDTLDGGAGNDVLDGGHGEDVLNGGDGDDLL 152
Cdd:pfam00353   2 GGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGNDTL 36
 
Name Accession Description Interval E-value
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 82-212 1.66e-09

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 57.99  E-value: 1.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544068990  82 GTHGDNTLNGTAAADAINGHGGDDAINGAGGDDFLQGGYGNDTLDGGAGNDVLDGGHGEDVLNGGDGDDLLISRADGREG 161
Cdd:COG2931   117 GGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTL 196

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2544068990 162 AIFYDPNRDEGDPYNELTNGKLYPDQPIPADDVMTGGAGADVFYIQTLINA 212
Cdd:COG2931   197 DGGGGDDTLGGGGGDDGLDGGDGDDGLGGGGGDDTLGGGGGGDGGGGGGGD 247
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 82-153 6.78e-09

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 56.07  E-value: 6.78e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2544068990  82 GTHGDNTLNGTAAADAINGHGGDDAINGAGGDDFLQGGYGNDTLDGGAGNDVLDGGHGEDVLNGGDGDDLLI 153
Cdd:COG2931   108 GGGGNDTLTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLT 179
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 82-153 1.03e-07

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 52.60  E-value: 1.03e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2544068990  82 GTHGDNTLNGTAAADAINGHGGDDAINGAGGDDFLQGGYGNDTLDGGAGNDVLDGGHGEDVLNGGDGDDLLI 153
Cdd:COG2931    99 GGTGDDTGDGGGGNDTLTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLD 170
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 82-153 1.55e-06

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 48.75  E-value: 1.55e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2544068990  82 GTHGDNTLNGTAAADAINGHGGDDAINGAGGDDFLQGGYGNDTLDGGAGNDVLDGGHGEDVLNGGDGDDLLI 153
Cdd:COG2931    90 GGDGGDGGGGGTGDDTGDGGGGNDTLTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLY 161
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
118-152 9.16e-06

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 42.04  E-value: 9.16e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2544068990 118 GGYGNDTLDGGAGNDVLDGGHGEDVLNGGDGDDLL 152
Cdd:pfam00353   2 GGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGNDTL 36
Peptidase_M10_C pfam08548
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 104-153 2.57e-05

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


Pssm-ID: 430067 [Multi-domain]  Cd Length: 222  Bit Score: 45.06  E-value: 2.57e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2544068990 104 DDAINGAGgDDFLQGGYGNDTLDGGAGNDVLDGGHGEDVLNGGDGDDLLI 153
Cdd:pfam08548  82 ENAIGGSG-NDVLIGNDADNILKGGAGNDILYGGGGADQLWGGAGNDIFV 130
Peptidase_M10_C pfam08548
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 96-157 5.43e-05

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


Pssm-ID: 430067 [Multi-domain]  Cd Length: 222  Bit Score: 43.90  E-value: 5.43e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2544068990  96 DAINGHGGDDAInGAGGDDFLQGGYGNDTLDGGAGNDVLDGGHGEDVLNGGDGDDLLISRAD 157
Cdd:pfam08548  83 NAIGGSGNDVLI-GNDADNILKGGAGNDILYGGGGADQLWGGAGNDIFVYASAKDSLTAAPD 143
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
109-143 8.18e-05

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 39.34  E-value: 8.18e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2544068990 109 GAGGDDFLQGGYGNDTLDGGAGNDVLDGGHGEDVL 143
Cdd:pfam00353   2 GGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGNDTL 36
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 82-153 9.31e-05

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 43.36  E-value: 9.31e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2544068990  82 GTHGDNTLNGTAAADAINGHGGDDAINGAGGDDFLQGGYGNDTLDGGAGNDVLDGGHGEDVLNGGDGDDLLI 153
Cdd:COG2931    81 GGGGDDTDGGGDGGDGGGGGTGDDTGDGGGGNDTLTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLY 152
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
100-134 1.39e-04

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 38.57  E-value: 1.39e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2544068990 100 GHGGDDAINGAGGDDFLQGGYGNDTLDGGAGNDVL 134
Cdd:pfam00353   2 GGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGNDTL 36
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 82-153 2.19e-03

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 39.50  E-value: 2.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2544068990  82 GTHGDNTLNGTAAADAINGHGGDDAINGAGGDDFLQGGYGNDTLDGGAGNDVLDGGHGEDVLNGGDGDDLLI 153
Cdd:COG2931    72 GGGGGDGGGGGGGDDTDGGGDGGDGGGGGTGDDTGDGGGGNDTLTGGDGNDTLTGGAGDDTLYGGAGNDTLT 143
Peptidase_M10_C pfam08548
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 82-132 3.48e-03

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


Pssm-ID: 430067 [Multi-domain]  Cd Length: 222  Bit Score: 38.51  E-value: 3.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2544068990  82 GTHGDNTLNGTAAADAINGHGGDDAINGAGGDDFLQGGYGNDTLDGGAGND 132
Cdd:pfam08548  86 GGSGNDVLIGNDADNILKGGAGNDILYGGGGADQLWGGAGNDIFVYASAKD 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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