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Conserved domains on  [gi|2546804459|ref|WP_301346401|]
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class II fructose-bisphosphate aldolase, partial [uncultured Muribaculum sp.]

Protein Classification

beta/alpha barrel domain-containing protein( domain architecture ID 229392)

beta/alpha barrel domain-containing protein belongs to a large superfamily with a wide variety of enzymatic functions

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TIM super family cl21457
TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate ...
 1-304 0e+00

TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate isomerase (TIM) which, in general, share an eight beta/alpha closed barrel structure.


The actual alignment was detected with superfamily member PRK07084:

Pssm-ID: 473867  Cd Length: 321  Bit Score: 609.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPILLRYMAQGAVEYAKTLGWEHPqIVLHLDHGDSFELCKDCIE 80
Cdd:PRK07084   28 AYNFNNMEQLQAIIQACVETKSPVILQVSKGARKYANATLLRYMAQGAVEYAKELGCPIP-IVLHLDHGDSFELCKDCID 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHTYTDPEEVIDFATRTGCDSLAISIG 160
Cdd:PRK07084  107 SGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSAEHHTYTQPEEVEDFVKKTGVDSLAISIG 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 161 TSHGAYKFKPEQCtrnadgklvPPPLAFDVLDAVMEKLPGFPIVLHGSSSVPQDEVDTINKYGGKLPDAIGIPEEELRKA 240
Cdd:PRK07084  187 TSHGAYKFKPGQC---------PPPLRFDILEEIEKRIPGFPIVLHGSSSVPQEYVKTINEYGGKLKDAIGIPEEQLRKA 257

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2546804459 241 SKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEAVLGSKDKA 304
Cdd:PRK07084  258 AKSAVCKINIDSDGRLAMTAAIRKVFDEKPEEFDPRKYLGPARDELKKLYKHKIINVLGSNGKA 321
 
Name Accession Description Interval E-value
PRK07084 PRK07084
class II fructose-1,6-bisphosphate aldolase;
1-304 0e+00

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180829  Cd Length: 321  Bit Score: 609.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPILLRYMAQGAVEYAKTLGWEHPqIVLHLDHGDSFELCKDCIE 80
Cdd:PRK07084   28 AYNFNNMEQLQAIIQACVETKSPVILQVSKGARKYANATLLRYMAQGAVEYAKELGCPIP-IVLHLDHGDSFELCKDCID 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHTYTDPEEVIDFATRTGCDSLAISIG 160
Cdd:PRK07084  107 SGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSAEHHTYTQPEEVEDFVKKTGVDSLAISIG 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 161 TSHGAYKFKPEQCtrnadgklvPPPLAFDVLDAVMEKLPGFPIVLHGSSSVPQDEVDTINKYGGKLPDAIGIPEEELRKA 240
Cdd:PRK07084  187 TSHGAYKFKPGQC---------PPPLRFDILEEIEKRIPGFPIVLHGSSSVPQEYVKTINEYGGKLKDAIGIPEEQLRKA 257

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2546804459 241 SKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEAVLGSKDKA 304
Cdd:PRK07084  258 AKSAVCKINIDSDGRLAMTAAIRKVFDEKPEEFDPRKYLGPARDELKKLYKHKIINVLGSNGKA 321
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-304 3.74e-138

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 391.76  E-value: 3.74e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPILLRYMAQGAVEYAKTlgwehPqIVLHLDHGDSFELCKDCIE 80
Cdd:COG0191    21 AFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASV-----P-VALHLDHGASFELIKRAID 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHH--TYTDPEEVIDFATRTGCDSLAIS 158
Cdd:COG0191    95 AGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAeaLYTDPEEAAEFVEETGVDALAVA 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 159 IGTSHGAYKFKPEqctrnadgklvpppLAFDVLDAVMEKLPgFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELR 238
Cdd:COG0191   175 IGTVHGVYKGEPK--------------LDFDRLKEIREAVP-VPLVLHGGS---------------------GVPDEEIR 218

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2546804459 239 KASKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEaVLGSKDKA 304
Cdd:COG0191   219 EAIKLGVAKINIDTDLRLAFTAAVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIR-LFGSAGKA 283
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 1-300 2.74e-134

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 381.49  E-value: 2.74e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPILLRYMAQGAVEYAKtlgweHPqIVLHLDHGDSFELCKDCIE 80
Cdd:cd00947    17 AFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERAS-----VP-VALHLDHGSSFELIKRAIR 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHTYTDPEEVIDFATRTGCDSLAISIG 160
Cdd:cd00947    91 AGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEEDGVVGDEGLLTDPEEAEEFVEETGVDALAVAIG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 161 TSHGAYKFkpeqctrnadgklVPPPLAFDVLDAVMEKLPgFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELRKA 240
Cdd:cd00947   171 TSHGAYKG-------------GEPKLDFDRLKEIAERVN-VPLVLHGGS---------------------GIPDEQIRKA 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 241 SKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEaVLGS 300
Cdd:cd00947   216 IKLGVCKININTDLRLAFTAALREYLAENPKEFDPRKYLAPAIEAVKEVVKHKME-LFGS 274
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
1-303 3.22e-127

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 363.66  E-value: 3.22e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNY--ANPILLRYMAQGAVEYAKTlgwehPqIVLHLDHGDSFELCKDC 78
Cdd:pfam01116  19 AFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKyaGGAEALAALVRAAAEAAGV-----P-VALHLDHGASFELIKEA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  79 IEHGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHTYTDPEEVIDFATRTGCDSLAIS 158
Cdd:pfam01116  93 IEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDGVVVDEKLYTDPEEAAEFVEATGVDALAVA 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 159 IGTSHGAYKFKPEqctrnadgklvpppLAFDVLDAVMEKLPgFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELR 238
Cdd:pfam01116 173 IGNVHGVYKPGPK--------------LDFDRLKEIQEAVP-VPLVLHGGS---------------------GVPDEDIR 216

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2546804459 239 KASKSAVCKINIDSDSRLAMTAAVRKtlfeHPEEFDPRKYLGPARDNMEKLYKHKIEaVLGSKDK 303
Cdd:pfam01116 217 KAIKLGVCKINIDTDLQLAFTAAVRE----YPPNKDPRKYLRPAEEAMKEVVKEKIR-LFGSAGK 276
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 1-304 4.83e-113

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 328.17  E-value: 4.83e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPIllrYMAQGAVEYAKTLGWEHPqIVLHLDHGDSFELCKDCIE 80
Cdd:TIGR01859  20 AFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGGY---KMAVAMVKTLIERMSIVP-VALHLDHGSSYESCIKAIK 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHTYTDPEEVIDFATRTGCDSLAISIG 160
Cdd:TIGR01859  96 AGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGIEDGVDEKEAELADPDEAEQFVKETGVDYLAAAIG 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 161 TSHGayKFKPEqctrnadgklvpPPLAFDVLDAVMEKLPgFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELRKA 240
Cdd:TIGR01859 176 TSHG--KYKGE------------PGLDFERLKEIKELTN-IPLVLHGAS---------------------GIPEEQIKKA 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2546804459 241 SKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEaVLGSKDKA 304
Cdd:TIGR01859 220 IKLGIAKINIDTDCRIAFTAAIRKVLTEKKDEYDPRKILGPAREAIKETVKEKMR-LFGSAGKA 282
Fbpase2_Halo NF041368
class II fructose-bisphosphate aldolase;
1-252 6.57e-45

class II fructose-bisphosphate aldolase;


Pssm-ID: 469259  Cd Length: 333  Bit Score: 155.19  E-value: 6.57e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYA---NPIL-LRYMaqgaVEYAKTLGWEHPQIV-LHLDH---GDSF 72
Cdd:NF041368   25 ASNVTEPDILVGLLRGAERADSDLVLQVSRGAAAFAgngDPAAgLRAF----GAYLEALAERYDVGVfLNVDHvtlPDDE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  73 ELCKDCIEHGF-SSVMIDGSHLPYEENVALTKKVVDYAHQ--YDVTVEGELGVLAGVEDEVSSDHHTYTDPEEVIDFATR 149
Cdd:NF041368  101 DFLDAAVESGIpSSVMVDASAEPFEENVERTREVVEMVDAadEDVLVEAELGRIAGVEDGIETDEAFYTDPEQAVEFVDR 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 150 TGCDSLAISIGTSHGAYKfkpeqcTRNADgklVPPPLAFDVLDAVMEKLPGFPIVLHGSSsvpqdevdtinkyggklpda 229
Cdd:NF041368  181 TGCDLLAVSVGTQHGVAK------GRDLD---LRPDLAREIRDALRDHGLDTPLVVHGSS-------------------- 231

                         250       260
                  ....*....|....*....|...
gi 2546804459 230 iGIPEEELRKASKSAVCKINIDS 252
Cdd:NF041368  232 -GLSPEQVRELLDAGVCKVNKNT 253
 
Name Accession Description Interval E-value
PRK07084 PRK07084
class II fructose-1,6-bisphosphate aldolase;
1-304 0e+00

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180829  Cd Length: 321  Bit Score: 609.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPILLRYMAQGAVEYAKTLGWEHPqIVLHLDHGDSFELCKDCIE 80
Cdd:PRK07084   28 AYNFNNMEQLQAIIQACVETKSPVILQVSKGARKYANATLLRYMAQGAVEYAKELGCPIP-IVLHLDHGDSFELCKDCID 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHTYTDPEEVIDFATRTGCDSLAISIG 160
Cdd:PRK07084  107 SGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSAEHHTYTQPEEVEDFVKKTGVDSLAISIG 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 161 TSHGAYKFKPEQCtrnadgklvPPPLAFDVLDAVMEKLPGFPIVLHGSSSVPQDEVDTINKYGGKLPDAIGIPEEELRKA 240
Cdd:PRK07084  187 TSHGAYKFKPGQC---------PPPLRFDILEEIEKRIPGFPIVLHGSSSVPQEYVKTINEYGGKLKDAIGIPEEQLRKA 257

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2546804459 241 SKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEAVLGSKDKA 304
Cdd:PRK07084  258 AKSAVCKINIDSDGRLAMTAAIRKVFDEKPEEFDPRKYLGPARDELKKLYKHKIINVLGSNGKA 321
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-304 3.74e-138

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 391.76  E-value: 3.74e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPILLRYMAQGAVEYAKTlgwehPqIVLHLDHGDSFELCKDCIE 80
Cdd:COG0191    21 AFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASV-----P-VALHLDHGASFELIKRAID 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHH--TYTDPEEVIDFATRTGCDSLAIS 158
Cdd:COG0191    95 AGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAeaLYTDPEEAAEFVEETGVDALAVA 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 159 IGTSHGAYKFKPEqctrnadgklvpppLAFDVLDAVMEKLPgFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELR 238
Cdd:COG0191   175 IGTVHGVYKGEPK--------------LDFDRLKEIREAVP-VPLVLHGGS---------------------GVPDEEIR 218

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2546804459 239 KASKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEaVLGSKDKA 304
Cdd:COG0191   219 EAIKLGVAKINIDTDLRLAFTAAVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIR-LFGSAGKA 283
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 1-300 2.74e-134

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 381.49  E-value: 2.74e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPILLRYMAQGAVEYAKtlgweHPqIVLHLDHGDSFELCKDCIE 80
Cdd:cd00947    17 AFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERAS-----VP-VALHLDHGSSFELIKRAIR 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHTYTDPEEVIDFATRTGCDSLAISIG 160
Cdd:cd00947    91 AGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEEDGVVGDEGLLTDPEEAEEFVEETGVDALAVAIG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 161 TSHGAYKFkpeqctrnadgklVPPPLAFDVLDAVMEKLPgFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELRKA 240
Cdd:cd00947   171 TSHGAYKG-------------GEPKLDFDRLKEIAERVN-VPLVLHGGS---------------------GIPDEQIRKA 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 241 SKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEaVLGS 300
Cdd:cd00947   216 IKLGVCKININTDLRLAFTAALREYLAENPKEFDPRKYLAPAIEAVKEVVKHKME-LFGS 274
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
1-303 3.22e-127

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 363.66  E-value: 3.22e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNY--ANPILLRYMAQGAVEYAKTlgwehPqIVLHLDHGDSFELCKDC 78
Cdd:pfam01116  19 AFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKyaGGAEALAALVRAAAEAAGV-----P-VALHLDHGASFELIKEA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  79 IEHGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHTYTDPEEVIDFATRTGCDSLAIS 158
Cdd:pfam01116  93 IEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDGVVVDEKLYTDPEEAAEFVEATGVDALAVA 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 159 IGTSHGAYKFKPEqctrnadgklvpppLAFDVLDAVMEKLPgFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELR 238
Cdd:pfam01116 173 IGNVHGVYKPGPK--------------LDFDRLKEIQEAVP-VPLVLHGGS---------------------GVPDEDIR 216

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2546804459 239 KASKSAVCKINIDSDSRLAMTAAVRKtlfeHPEEFDPRKYLGPARDNMEKLYKHKIEaVLGSKDK 303
Cdd:pfam01116 217 KAIKLGVCKINIDTDLQLAFTAAVRE----YPPNKDPRKYLRPAEEAMKEVVKEKIR-LFGSAGK 276
PRK09196 PRK09196
fructose-bisphosphate aldolase class II;
1-296 1.06e-123

fructose-bisphosphate aldolase class II;


Pssm-ID: 181691  Cd Length: 347  Bit Score: 357.73  E-value: 1.06e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPILLRYMAQGAVEyaktlgwEHPQI--VLHLDHGDSFELCKDC 78
Cdd:PRK09196   22 AFNVNNLEQVQAIMEAADETDSPVILQASAGARKYAGEPFLRHLILAAVE-------EYPHIpvVMHQDHGNSPATCQRA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  79 IEHGFSSVMIDGSHLP-------YEENVALTKKVVDYAHQYDVTVEGELGVL-------AGVED----EVSSDH-HTYTD 139
Cdd:PRK09196   95 IQLGFTSVMMDGSLKAdgktpasYEYNVDVTRKVVEMAHACGVSVEGELGCLgsletgmGGEEDghgaEGKLSHdQLLTD 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 140 PEEVIDFATRTGCDSLAISIGTSHGAYKFkpeqcTRNADGKLvpppLAFDVLDAVMEKLPGFPIVLHGSSSVPQDEVDTI 219
Cdd:PRK09196  175 PEEAADFVKKTQVDALAIAIGTSHGAYKF-----TRKPTGDV----LAIDRIKEIHARLPNTHLVMHGSSSVPQELLDII 245

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2546804459 220 NKYGGKLPDAIGIPEEELRKASKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEA 296
Cdd:PRK09196  246 NEYGGDMPETYGVPVEEIQEGIKHGVRKVNIDTDLRLAMTGAIRRFLAENPSEFDPRKYLKPAMEAMKKICKARYEA 322
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 1-304 4.83e-113

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 328.17  E-value: 4.83e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPIllrYMAQGAVEYAKTLGWEHPqIVLHLDHGDSFELCKDCIE 80
Cdd:TIGR01859  20 AFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGGY---KMAVAMVKTLIERMSIVP-VALHLDHGSSYESCIKAIK 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHTYTDPEEVIDFATRTGCDSLAISIG 160
Cdd:TIGR01859  96 AGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGIEDGVDEKEAELADPDEAEQFVKETGVDYLAAAIG 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 161 TSHGayKFKPEqctrnadgklvpPPLAFDVLDAVMEKLPgFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELRKA 240
Cdd:TIGR01859 176 TSHG--KYKGE------------PGLDFERLKEIKELTN-IPLVLHGAS---------------------GIPEEQIKKA 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2546804459 241 SKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEaVLGSKDKA 304
Cdd:TIGR01859 220 IKLGIAKINIDTDCRIAFTAAIRKVLTEKKDEYDPRKILGPAREAIKETVKEKMR-LFGSAGKA 282
PRK13399 PRK13399
fructose-bisphosphate aldolase class II;
1-296 6.38e-110

fructose-bisphosphate aldolase class II;


Pssm-ID: 184029  Cd Length: 347  Bit Score: 322.50  E-value: 6.38e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPILLRYMAQGAVEyaktlgwEHPQI--VLHLDHGDSFELCKDC 78
Cdd:PRK13399   22 AFNVNNMEQILAIMEAAEATDSPVILQASRGARKYAGDAMLRHMVLAAAE-------MYPDIpiCLHQDHGNSPATCQSA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  79 IEHGFSSVMIDGSHLP-------YEENVALTKKVVDYAHQYDVTVEGELGVL-------AGVEDEVS-----SDHHTYTD 139
Cdd:PRK13399   95 IRSGFTSVMMDGSLLAdgktpasYDYNVDVTRRVTEMAHAVGVSVEGELGCLgsletgeAGEEDGVGaegklSHDQMLTD 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 140 PEEVIDFATRTGCDSLAISIGTSHGAYKFkpeqcTRNADGKLvpppLAFDVLDAVMEKLPGFPIVLHGSSSVPQDEVDTI 219
Cdd:PRK13399  175 PDQAVDFVQRTGVDALAIAIGTSHGAYKF-----TRKPDGDI----LAIDRIEEIHARLPNTHLVMHGSSSVPQELQEII 245

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2546804459 220 NKYGGKLPDAIGIPEEELRKASKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEA 296
Cdd:PRK13399  246 NAYGGKMKETYGVPVEEIQRGIKHGVRKVNIDTDIRLAMTGAIRKVLAEHPSEFDPRKALKPAMKAMTALCKQRFEA 322
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
1-304 5.56e-100

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 295.10  E-value: 5.56e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPILLRYMAQGAVEYAKTlgwehpQIVLHLDHGDSFELCKDCIE 80
Cdd:PRK12857   22 AFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKYAGIEYISAMVRTAAEKASV------PVALHLDHGTDFEQVMKCIR 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHH--TYTDPEEVIDFATRTGCDSLAIS 158
Cdd:PRK12857   96 NGFTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELGKIGGTEDDITVDEReaAMTDPEEARRFVEETGVDALAIA 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 159 IGTSHGAYKFKPEqctrnadgklvpppLAFDVLDAVMEKLPgFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELR 238
Cdd:PRK12857  176 IGTAHGPYKGEPK--------------LDFDRLAKIKELVN-IPIVLHGSS---------------------GVPDEAIR 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2546804459 239 KASKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEaVLGSKDKA 304
Cdd:PRK12857  220 KAISLGVRKVNIDTNIREAFVARLREVLEKNPDEIDPRKILGPAREAAKEVIREKIR-LFGSAGKA 284
FruBisAldo_II_B TIGR01521
fructose-bisphosphate aldolase, class II, Calvin cycle subtype; Members of this family are ...
 1-296 2.83e-95

fructose-bisphosphate aldolase, class II, Calvin cycle subtype; Members of this family are class II examples of the enzyme fructose-bisphosphate aldolase, an enzyme both of glycolysis and (in the opposite direction) of the Calvin cycle of CO2 fixation. A deep split separates the tightly conserved yeast/E. coli/Mycobacterium subtype (all species lacking the Calvin cycle) represented by model TIGR01520 from a broader group of aldolases that includes both tagatose- and fructose-bisphosphate aldolases. This model represents a distinct, elongated, very well conserved subtype within the latter group. Most species with this aldolase subtype have the Calvin cycle.


Pssm-ID: 130584  Cd Length: 347  Bit Score: 285.28  E-value: 2.83e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPILLRYMAQGAVEYaktlgWEHPQIVLHLDHGDSFELCKDCIE 80
Cdd:TIGR01521  20 AFNVNNMEQMRAIMEAADKTDSPVILQASRGARSYAGAPFLRHLILAAIEE-----YPHIPVVMHQDHGNSPATCQRAIQ 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGS-----HLP--YEENVALTKKVVDYAHQYDVTVEGELGVL-------AGVED----EVSSDH-HTYTDPE 141
Cdd:TIGR01521  95 LGFTSVMMDGSlredaKTPadYDYNVRVTAEVVAFAHAVGASVEGELGCLgsletgmGEAEDghgfEGVLDHsQLLTDPE 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 142 EVIDFATRTGCDSLAISIGTSHGAYKFkpeqcTRNADGKLvpppLAFDVLDAVMEKLPGFPIVLHGSSSVPQDEVDTINK 221
Cdd:TIGR01521 175 EAADFVKKTKVDALAVAIGTSHGAYKF-----TRKPTGEV----LAIQRIEEIHARLPDTHLVMHGSSSVPQEWLDIINE 245

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2546804459 222 YGGKLPDAIGIPEEELRKASKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEA 296
Cdd:TIGR01521 246 YGGEIKETYGVPVEEIVEGIKYGVRKVNIDTDLRLASTAAFRRFAAQNPSEFDPRKFLKPTVEAMRDVCIARYEA 320
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-304 3.19e-92

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 275.35  E-value: 3.19e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPI-LLRYMAQGAVEyakTLGWEHPqIVLHLDHGDSFELCKDCI 79
Cdd:TIGR00167  22 AFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYIAGLgAISAMVKAMSE---AYPYGVP-VALHLDHGASEEDCAQAV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  80 EHGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHT--YTDPEEVIDFATRTGCDSLAI 157
Cdd:TIGR00167  98 KAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGVSVADESalYTDPEEAKEFVKLTGVDSLAA 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 158 SIGTSHGAYKFKPEQctrnadgklvpppLAFDVLDAVmEKLPGFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEEL 237
Cdd:TIGR00167 178 AIGNVHGVYKGEPKG-------------LDFERLEEI-QKYVNLPLVLHGGS---------------------GIPDEEI 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2546804459 238 RKASKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEaVLGSKDKA 304
Cdd:TIGR00167 223 KKAISLGVVKVNIDTELQIAFAAAVRNYYAENKDYYDPRVWLRPGEKAMKEVVLEKIK-LFGSANKA 288
gatY PRK12737
tagatose-bisphosphate aldolase subunit GatY;
1-304 3.42e-86

tagatose-bisphosphate aldolase subunit GatY;


Pssm-ID: 183710  Cd Length: 284  Bit Score: 260.01  E-value: 3.42e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPILLRYMAQGAVEYaktlgWEHPqIVLHLDHGDSFELCKDCIE 80
Cdd:PRK12737   22 AFNIHNLETLQVVVETAAELRSPVILAGTPGTFSYAGTDYIVAIAEVAARK-----YNIP-LALHLDHHEDLDDIKKKVR 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDE--VSSDHHTYTDPEEVIDFATRTGCDSLAIS 158
Cdd:PRK12737   96 AGIRSVMIDGSHLSFEENIAIVKEVVEFCHRYDASVEAELGRLGGQEDDlvVDEKDAMYTNPDAAAEFVERTGIDSLAVA 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 159 IGTSHGAYKFKPEqctrnadgklvpppLAFDVLDAVMEKLpGFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELR 238
Cdd:PRK12737  176 IGTAHGLYKGEPK--------------LDFERLAEIREKV-SIPLVLHGAS---------------------GVPDEDVK 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2546804459 239 KASKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEaVLGSKDKA 304
Cdd:PRK12737  220 KAISLGICKVNVATELKIAFSDAVKKYFYENPKANDPRKYMTPGKAAMKEVVREKIK-VCGSEGKL 284
PRK05835 PRK05835
class II fructose-1,6-bisphosphate aldolase;
1-303 1.28e-83

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180280 [Multi-domain]  Cd Length: 307  Bit Score: 254.13  E-value: 1.28e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGArnyanpilLRYMA-QGAVEYAKTLGWEHPQI--VLHLDHGDSFELCKD 77
Cdd:PRK05835   21 AFNFVNFEMLNAIFEAGNEENSPLFIQASEGA--------IKYMGiDMAVGMVKIMCERYPHIpvALHLDHGTTFESCEK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  78 CIEHGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHH--TYTDPEEVIDFATRTGCDSL 155
Cdd:PRK05835   93 AVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKdaVLVNPKEAEQFVKESQVDYL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 156 AISIGTSHGAYKFKPEqctrnadgklvpPPLAFDVLDAVmEKLPGFPIVLHGSSSVPQDEVDTINKYGGKLPDAIGIPEE 235
Cdd:PRK05835  173 APAIGTSHGAFKFKGE------------PKLDFERLQEV-KRLTNIPLVLHGASAIPDDVRKSYLDAGGDLKGSKGVPFE 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2546804459 236 ELRKASKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEaVLGSKDK 303
Cdd:PRK05835  240 FLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMK-LLGSANK 306
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 1-304 1.53e-83

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 253.13  E-value: 1.53e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPILLRYMAQGAVEYaktlgWEHPqIVLHLDHGDSFELCKDCIE 80
Cdd:PRK09195   22 AFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAGTEYLLAIVSAAAKQ-----YHHP-LALHLDHHEKFDDIAQKVR 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDE--VSSDHHTYTDPEEVIDFATRTGCDSLAIS 158
Cdd:PRK09195   96 SGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQEDDlqVDEADALYTDPAQAREFVEATGIDSLAVA 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 159 IGTSHGAYKFKPEqctrnadgklvpppLAFDVLDAVMEKLpGFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELR 238
Cdd:PRK09195  176 IGTAHGMYKGEPK--------------LDFDRLENIRQWV-NIPLVLHGAS---------------------GLPTKDIQ 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2546804459 239 KASKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIeAVLGSKDKA 304
Cdd:PRK09195  220 QTIKLGICKVNVATELKIAFSQALKNYLTEHPEANDPRHYLQPAKSAMKDVVSKVI-ADCGCEGKA 284
PRK08610 PRK08610
fructose-bisphosphate aldolase; Reviewed
 2-304 8.32e-76

fructose-bisphosphate aldolase; Reviewed


Pssm-ID: 181501  Cd Length: 286  Bit Score: 233.73  E-value: 8.32e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   2 FNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPI-LLRYMAQGAVE-YAKTLgwehpQIVLHLDHGDSFELCKDCI 79
Cdd:PRK08610   23 YNLNNLEFTQAILEASQEENAPVILGVSEGAARYMSGFyTVVKMVEGLMHdLNITI-----PVAIHLDHGSSFEKCKEAI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  80 EHGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHTYTDPEEVIDFATRTGCDSLAISI 159
Cdd:PRK08610   98 DAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVGGQEDDVVADGIIYADPKECQELVEKTGIDALAPAL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 160 GTSHGAYKFKPEqctrnadgklvpppLAFDVLDAVMEKlPGFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELRK 239
Cdd:PRK08610  178 GSVHGPYKGEPK--------------LGFKEMEEIGLS-TGLPLVLHGGT---------------------GIPTKDIQK 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2546804459 240 ASKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEAvLGSKDKA 304
Cdd:PRK08610  222 AIPFGTAKINVNTENQIASAKAVRDVLNNDKEVYDPRKYLGPAREAIKETVKGKIKE-FGTSNRA 285
tag_bisphos_ald TIGR01858
class II aldolase, tagatose bisphosphate family; This model describes tagatose-1, ...
 1-304 4.46e-75

class II aldolase, tagatose bisphosphate family; This model describes tagatose-1,6-bisphosphate aldolases, and perhaps other closely related class II aldolases. This tetrameric, Zn2+-dependent enzyme is related to the class II fructose bisphosphate aldolase; fructose 1,6-bisphosphate and tagatose 1,6 bisphosphate differ only in chirality at C4.


Pssm-ID: 130917  Cd Length: 282  Bit Score: 231.67  E-value: 4.46e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPillRYMAQGAVEYAKTlgWEHPqIVLHLDHGDSFELCKDCIE 80
Cdd:TIGR01858  20 AFNIHNLETIQAVVETAAEMRSPVILAGTPGTFKHAGT---EYIVALCSAASTT--YNMP-LALHLDHHESLDDIRQKVH 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHT--YTDPEEVIDFATRTGCDSLAIS 158
Cdd:TIGR01858  94 AGVRSAMIDGSHFPFAQNVKLVKEVVDFCHRQDCSVEAELGRLGGVEDDLSVDEEDalYTDPQEAKEFVEATGVDSLAVA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 159 IGTSHGAYKFKPEqctrnadgklvpppLAFDVLDAVMEKLpGFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELR 238
Cdd:TIGR01858 174 IGTAHGLYKKTPK--------------LDFDRLAEIREVV-DVPLVLHGAS---------------------DVPDEDVR 217

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2546804459 239 KASKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIeAVLGSKDKA 304
Cdd:TIGR01858 218 RTIELGICKVNVATELKIAFSGAVKAYFAENPQANDPRYYMRPGKDAMKKVVRNKI-NVCGSAGRA 282
PRK07709 PRK07709
fructose-bisphosphate aldolase; Provisional
 2-304 9.58e-71

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 169068  Cd Length: 285  Bit Score: 220.70  E-value: 9.58e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   2 FNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPI-LLRYMAQGAVEyakTLGWEHPqIVLHLDHGDSFELCKDCIE 80
Cdd:PRK07709   23 FNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHMTGFkTVVAMVKALIE---EMNITVP-VAIHLDHGSSFEKCKEAID 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHTYTDPEEVIDFATRTGCDSLAISIG 160
Cdd:PRK07709   99 AGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQEDDVIAEGVIYADPAECKHLVEATGIDCLAPALG 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 161 TSHGAYKFKPEqctrnadgklvpppLAFDVLDAVMEkLPGFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELRKA 240
Cdd:PRK07709  179 SVHGPYKGEPN--------------LGFAEMEQVRD-FTGVPLVLHGGT---------------------GIPTADIEKA 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2546804459 241 SKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEAvLGSKDKA 304
Cdd:PRK07709  223 ISLGTSKINVNTENQIEFTKAVREVLNKDQEVYDPRKFIGPGRDAIKATVIGKIRE-FGSNGKA 285
PRK08185 PRK08185
hypothetical protein; Provisional
 1-304 2.60e-67

hypothetical protein; Provisional


Pssm-ID: 181275  Cd Length: 283  Bit Score: 211.51  E-value: 2.60e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVskgarnyaNPILLRYMAQGAVEYAKTLGWEHP-QIVLHLDHGDSFELCKDCI 79
Cdd:PRK08185   17 AFNVADSCFLRAVVEEAEANNAPAIIAI--------HPNELDFLGDNFFAYVRERAKRSPvPFVIHLDHGATIEDVMRAI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  80 EHGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLA--GVEDEVSSDHHTYTDPEEVIDFATRTGCDSLAI 157
Cdd:PRK08185   89 RCGFTSVMIDGSLLPYEENVALTKEVVELAHKVGVSVEGELGTIGntGTSIEGGVSEIIYTDPEQAEDFVSRTGVDTLAV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 158 SIGTSHGAYK--FKPEqctrnadgklvpppLAFDVLDAVMEKLpGFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEE 235
Cdd:PRK08185  169 AIGTAHGIYPkdKKPE--------------LQMDLLKEINERV-DIPLVLHGGS---------------------ANPDA 212

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2546804459 236 ELRKASKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIeAVLGSKDKA 304
Cdd:PRK08185  213 EIAESVQLGVGKINISSDMKYAFFKKVREILSDNPSLYEPNQIYPSAIEAAKEVVRHKM-DLFNSTGKA 280
gatY PRK07998
class II aldolase;
1-305 2.77e-63

class II aldolase;


Pssm-ID: 181192  Cd Length: 283  Bit Score: 201.14  E-value: 2.77e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPILLRYMAQGAVEYAKTLgwehpqIVLHLDHGDSFELCKDCIE 80
Cdd:PRK07998   22 AFNTTNLETTISILNAIERSGLPNFIQIAPTNAQLSGYDYIYEIVKRHADKMDVP------VSLHLDHGKTFEDVKQAVR 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHTYTDPEEVIDFATRTGCDSLAISIG 160
Cdd:PRK07998   96 AGFTSVMIDGAALPFEENIAFTKEAVDFAKSYGVPVEAELGAILGKEDDHVSEADCKTEPEKVKDFVERTGCDMLAVSIG 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 161 TSHGAYKfkpeqctrnadgklvPPPLAFDVLDAVMEKLPgFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELRKA 240
Cdd:PRK07998  176 NVHGLED---------------IPRIDIPLLKRIAEVSP-VPLVIHGGS---------------------GIPPEILRSF 218

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2546804459 241 SKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEAVLGSKDKAL 305
Cdd:PRK07998  219 VNYKVAKVNIASDLRKAFITTVGKAYVNNHNEANLARVMAKAKQAVEEDVYSKIKMMNSNHRLVR 283
kbaY PRK12738
tagatose-bisphosphate aldolase subunit KbaY;
1-305 2.45e-60

tagatose-bisphosphate aldolase subunit KbaY;


Pssm-ID: 183711  Cd Length: 286  Bit Score: 194.10  E-value: 2.45e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYanpILLRYMAqgAVEYAKTLGWEHPqIVLHLDHGDSFELCKDCIE 80
Cdd:PRK12738   22 AFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKH---IALEEIY--ALCSAYSTTYNMP-LALHLDHHESLDDIRRKVH 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHT--YTDPEEVIDFATRTGCDSLAIS 158
Cdd:PRK12738   96 AGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESafLTDPQEAKRFVELTGVDSLAVA 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 159 IGTSHGAYKFKPEqctrnadgklvpppLAFDVLDAVMEKLpGFPIVLHGSSSVpqdevdtinkyggklpdaigiPEEELR 238
Cdd:PRK12738  176 IGTAHGLYSKTPK--------------IDFQRLAEIREVV-DVPLVLHGASDV---------------------PDEFVR 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2546804459 239 KASKSAVCKINIDSDSRLAMTAAVRKTLFEHPEEFDPRKYLGPARDNMEKLYKHKIEaVLGSKDKAL 305
Cdd:PRK12738  220 RTIELGVTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKIN-VCGSANRIS 285
PRK06806 PRK06806
class II aldolase;
1-304 1.92e-57

class II aldolase;


Pssm-ID: 180705  Cd Length: 281  Bit Score: 186.11  E-value: 1.92e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPILLRYMAQGAVEYAKTlgwehpQIVLHLDHGDSFELCKDCIE 80
Cdd:PRK06806   22 AFSVANMEMVMGAIKAAEELNSPIILQIAEVRLNHSPLHLIGPLMVAAAKQAKV------PVAVHFDHGMTFEKIKEALE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHTYTDPEEVIDFATRTGCDSLAISIG 160
Cdd:PRK06806   96 IGFTSVMFDGSHLPLEENIQKTKEIVELAKQYGATVEAEIGRVGGSEDGSEDIEMLLTSTTEAKRFAEETDVDALAVAIG 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 161 TSHGAYKFKPEqctrnadgklvpppLAFDVLDAVMEKLPgFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELRKA 240
Cdd:PRK06806  176 NAHGMYNGDPN--------------LRFDRLQEINDVVH-IPLVLHGGS---------------------GISPEDFKKC 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2546804459 241 SKSAVCKINIDSDSRLAMTAAVRKtLFEHPEEFDprkYLGPARDNMEKLY---KHKIEaVLGSKDKA 304
Cdd:PRK06806  220 IQHGIRKINVATATFNSVITAVNN-LVLNTPYSD---YFTYHQDVIKAAYenvKKHMQ-IFGSENKA 281
PRK07315 PRK07315
fructose-bisphosphate aldolase; Provisional
 2-304 2.31e-52

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 180926  Cd Length: 293  Bit Score: 173.53  E-value: 2.31e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   2 FNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYANPI-LLRYMAQGAVEyakTLGWEHPqIVLHLDHGDsFELCKDCIE 80
Cdd:PRK07315   23 FNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGYkVCKNLIENLVE---SMGITVP-VAIHLDHGH-YEDALECIE 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  81 HGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHtyTDPEEVIDFATRTGCDSLAISIG 160
Cdd:PRK07315   98 VGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGIIGKGE--LAPIEDAKAMVETGIDFLAAGIG 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 161 TSHGAYkfkPEqctrNADGklvpppLAFDVLDAVMEKLPGFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELRKA 240
Cdd:PRK07315  176 NIHGPY---PE----NWEG------LDLDHLEKLTEAVPGFPIVLHGGS---------------------GIPDDQIQEA 221

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2546804459 241 SKSAVCKINIDSDSRLAMTAAVRKTL--FEHPEE-------FDPRKYLGPARDNMEKLYKHKIEaVLGSKDKA 304
Cdd:PRK07315  222 IKLGVAKVNVNTECQIAFANATRKFArdYEANEAeydkkklFDPRKFLAPGVKAIQASVEERID-VFGSANKA 293
PRK06801 PRK06801
ketose 1,6-bisphosphate aldolase;
1-249 1.64e-46

ketose 1,6-bisphosphate aldolase;


Pssm-ID: 180701  Cd Length: 286  Bit Score: 157.99  E-value: 1.64e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKgarnyanpILLRYMA-QGAVEYAKTLGWEHP-QIVLHLDHGDSFELCKDC 78
Cdd:PRK06801   22 AFNVLDSHFLRALFAAAKQERSPFIINIAE--------VHFKYISlESLVEAVKFEAARHDiPVVLNLDHGLHFEAVVRA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  79 IEHGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVED---EVSSDHHTYTDPEEVIDFATRTGCDSL 155
Cdd:PRK06801   94 LRLGFSSVMFDGSTLEYEENVRQTREVVKMCHAVGVSVEAELGAVGGDEGgalYGEADSAKFTDPQLARDFVDRTGIDAL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 156 AISIGTSHGAYKFKPEqctrnadgklvpppLAFDVLDAVMEKLpGFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEE 235
Cdd:PRK06801  174 AVAIGNAHGKYKGEPK--------------LDFARLAAIHQQT-GLPLVLHGGS---------------------GISDA 217

                         250
                  ....*....|....
gi 2546804459 236 ELRKASKSAVCKIN 249
Cdd:PRK06801  218 DFRRAIELGIHKIN 231
Fbpase2_Halo NF041368
class II fructose-bisphosphate aldolase;
1-252 6.57e-45

class II fructose-bisphosphate aldolase;


Pssm-ID: 469259  Cd Length: 333  Bit Score: 155.19  E-value: 6.57e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYA---NPIL-LRYMaqgaVEYAKTLGWEHPQIV-LHLDH---GDSF 72
Cdd:NF041368   25 ASNVTEPDILVGLLRGAERADSDLVLQVSRGAAAFAgngDPAAgLRAF----GAYLEALAERYDVGVfLNVDHvtlPDDE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  73 ELCKDCIEHGF-SSVMIDGSHLPYEENVALTKKVVDYAHQ--YDVTVEGELGVLAGVEDEVSSDHHTYTDPEEVIDFATR 149
Cdd:NF041368  101 DFLDAAVESGIpSSVMVDASAEPFEENVERTREVVEMVDAadEDVLVEAELGRIAGVEDGIETDEAFYTDPEQAVEFVDR 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 150 TGCDSLAISIGTSHGAYKfkpeqcTRNADgklVPPPLAFDVLDAVMEKLPGFPIVLHGSSsvpqdevdtinkyggklpda 229
Cdd:NF041368  181 TGCDLLAVSVGTQHGVAK------GRDLD---LRPDLAREIRDALRDHGLDTPLVVHGSS-------------------- 231

                         250       260
                  ....*....|....*....|...
gi 2546804459 230 iGIPEEELRKASKSAVCKINIDS 252
Cdd:NF041368  232 -GLSPEQVRELLDAGVCKVNKNT 253
FTBP_aldolase_II cd00453
Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1, ...
 1-302 4.61e-42

Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to yield fructose-1,6-bisphosphate. TBP-aldolase is tetrameric and produces tagarose-1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. Although structurally similar, the class I aldolases use a different mechanism and are believed to have an independent evolutionary origin.


Pssm-ID: 238255  Cd Length: 340  Bit Score: 148.03  E-value: 4.61e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVS-KGARNYANPILLRYMAQGAVEYAKTLGWEHPQ---------IVLHLDHGD 70
Cdd:cd00453    17 AVNCVGTDSINAVLETAAKVKAPVIVQFSnGGASFIAGKGVKSDVPQGAAILGAISGAHHVHqmaehygvpVILHTDHCA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  71 SFEL-------------CKDCIEHGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHHT- 136
Cdd:cd00453    97 KKLLpwidglldagekhFAATGKPLFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELGCTGGEEDGVDNSHMDa 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 137 ---YTDPEEVIDFATRTGC----DSLAISIGTSHGAYKfkpeqctrNADGKLVPPPLAfDVLDAVMEK--LPG--FPIVL 205
Cdd:cd00453   177 salYTQPEDVDYAYTELSKisprFTIAASFGNVHGVYK--------KGNVVLTPTILR-DSQEYVSKKhnLPHnsLNFVF 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 206 HGSSsvpqdevdtinkyggklpdaiGIPEEELRKASKSAVCKINIDSDSRLAMTAAVRKTLFEHPEE------------- 272
Cdd:cd00453   248 HGGS---------------------GSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANEAYlqgqlgnpkgedq 306

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2546804459 273 -----FDPRKYLGPARDNMEKLYKHKIEaVLGSKD 302
Cdd:cd00453   307 pnkkyYDPRVWLRAGQTSMIARLEKAFQ-ELNAID 340
PLN02858 PLN02858
fructose-bisphosphate aldolase
 1-304 4.71e-37

fructose-bisphosphate aldolase


Pssm-ID: 215463 [Multi-domain]  Cd Length: 1378  Bit Score: 140.37  E-value: 4.71e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459    1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYAN-PILLRYMAQGAVEYAKtlgwehpqIVLHLDHGDSFELCKDCI 79
Cdd:PLN02858  1118 AFNVYNLEGIEAVVAAAEAEKSPAILQVHPGALKQGGiPLVSCCIAAAEQASVP--------ITVHFDHGTSKHELLEAL 1189

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   80 EHGFSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSSDHH--TYTDPEEVIDFATRTGCDSLAI 157
Cdd:PLN02858  1190 ELGFDSVMVDGSHLSFTENISYTKSISSLAHSKGLMVEAELGRLSGTEDGLTVEEYeaKLTDVDQAKEFIDETGIDALAV 1269

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  158 SIGTSHGAYKfkpeqctrnADGklvpPPLAFDVLDAV----MEKlpGFPIVLHGSSsvpqdevdtinkyggklpdaiGIP 233
Cdd:PLN02858  1270 CIGNVHGKYP---------ASG----PNLRLDLLKELralsSKK--GVLLVLHGAS---------------------GLP 1313

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2546804459  234 EEELRKASKSAVCKINIDSDSRLAMTAAVRKtlfehPEEFDPRKYLGPARDNMEKLYKHKIEaVLGSKDKA 304
Cdd:PLN02858  1314 ESLIKECIENGVRKFNVNTEVRTAYMEALSS-----PKKTDLIDVMSAAKEAMKAVVAEKLR-LFGSAGKA 1378
PRK09197 PRK09197
fructose-bisphosphate aldolase; Provisional
 1-286 5.16e-27

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 236406  Cd Length: 350  Bit Score: 107.96  E-value: 5.16e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSKGARNYA-----NPILLRYMAQGAV---EYAKTLGWEHP-QIVLHLDHgds 71
Cdd:PRK09197   25 AVNVVGTDSINAVLEGAAEAKSPVIIQFSNGGAAFIagkgvKDDGQGAAVLGAIagaKHVHEVAEHYGvPVILHTDH--- 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  72 felC-KD-------CIEHG-----------FSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDEVSS 132
Cdd:PRK09197  102 ---CaKKllpwidgLLDAGekhfaaggkplFSSHMIDLSEEPLEENIEICSKYLERMAKAGMTLEIELGVTGGEEDGVDN 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 133 DHHT----YTDPEEVIDFATRTGCDS----LAISIGTSHGAYkfKPeqctrnadG--KLVPPPLAfDVLDAVMEKL---- 198
Cdd:PRK09197  179 SHEDnsklYTQPEDVLYAYEALGKISgrftIAASFGNVHGVY--KP--------GnvKLRPEILK-DSQEYVSKKFglpa 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 199 -PgFPIVLHGSSsvpqdevdtinkyggklpdaiGIPEEELRKASKSAVCKINIDSDSRLAMTAAVRKTLFEH-------- 269
Cdd:PRK09197  248 kP-FDFVFHGGS---------------------GSTLEEIREAVSYGVVKMNIDTDTQWAFWRGVLDYYFKNydylqgqv 305

                         330       340
                  ....*....|....*....|....*..
gi 2546804459 270 --PEE--------FDPRKYLGPARDNM 286
Cdd:PRK09197  306 gnPEGedkpnkkyYDPRVWLRAAEASM 332
FBP_aldolase_IIA cd00946
Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the ...
 1-288 7.34e-20

Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is homodimeric and used in gluconeogenesis and glycolysis. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238476  Cd Length: 345  Bit Score: 88.19  E-value: 7.34e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459   1 AFNFNNMEQLQAIIKAAAEDKSPVILQVSK-GARNYANPIL----LRYMAQGAV-------EYAKTLGwehPQIVLHLDH 68
Cdd:cd00946    20 AVNCTSSSTINAVLEAARDAKSPIIIQFSNgGAAFYAGKGLknekQKASIAGAIaaahhvrSMAEHYG---VPVVLHTDH 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459  69 ----------------GDSFElckdciEHG---FSSVMIDGSHLPYEENVALTKKVVDYAHQYDVTVEGELGVLAGVEDE 129
Cdd:cd00946    97 cakkllpwfdglleadEEYFK------QHGeplFSSHMLDLSEEPLEENIEICKKYLERMAKINMWLEMEIGITGGEEDG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 130 VSSDHHT----YTDPEEVID----FATRTGCDSLAISIGTSHGAYKfkpeqctrNADGKLVPPPLAfDVLDAVMEKL--- 198
Cdd:cd00946   171 VDNSGVDnaelYTQPEDVWYvyeaLSKISPNFSIAAAFGNVHGVYK--------PGNVKLQPEILG-EHQDYVREKLgla 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2546804459 199 PGFPI--VLHGSSsvpqdevdtinkyggklpdaiGIPEEELRKASKSAVCKINIDSDSRLAMTAAVRKTLFEH------- 269
Cdd:cd00946   242 DDKPLyfVFHGGS---------------------GSTKEEIREAISYGVVKMNIDTDTQWAYWEGVRNYYLKNedylqgq 300

                         330       340       350
                  ....*....|....*....|....*....|
gi 2546804459 270 ---PE--------EFDPRKYLGPARDNMEK 288
Cdd:cd00946   301 ignPEgpdkpnkkYYDPRVWLREGEKSMVA 330
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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