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Conserved domains on  [gi|2550912442|ref|WP_302278727|]
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glycoside hydrolase family 140 protein [Barnesiella intestinihominis]

Protein Classification

glycoside hydrolase family 140 protein( domain architecture ID 10590304)

glycoside hydrolase family 140 protein contains DUF4038 and collagen-binding domains, and is similar to Bacteroides thetaiotaomicron glycoside hydrolase BT1012, an endo-apiosidase that is part of the rhamnogalacturonan-II degradome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4038 pfam13204
Protein of unknown function (DUF4038); A family of putative cellulases.
 42-350 1.14e-140

Protein of unknown function (DUF4038); A family of putative cellulases.


:

Pssm-ID: 463808  Cd Length: 320  Bit Score: 405.50  E-value: 1.14e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550912442  42 NGRFLQHTDGTPFLYLGDTAWELIYRLNEPEVELYMENRRAKGFTVIQTVILSELDGSDGIN----RPLINGSPST-PDP 116
Cdd:pfam13204   1 NGRYLVHADGKPFFWLGDTAWELFHRLTREEAEYYLDDRAEQGFNVIQAVVLAELDGLTSPNaygdLPLIDGDPFTqPNE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550912442 117 DYFKWVDRVLEIAGEKGLYVGLLPTWGDKVDKQWGAGPEIFDEANAREYGRWLGRRYADTPNIIWIIGGDRSGEGkNFTV 196
Cdd:pfam13204  81 AYFDHVDYIVDKAAEKGIYIALVPTWGDNVKDGWGGGPEIFNPENAKAYGRFLGARYKDFPNIIWILGGDRDGDE-DREV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550912442 197 WKAMAEGIKECDKRHLMTCHPQGEHSSSFWFHDETWLDFNMFQSGHAQRDYAIYrRLLLNDLQKQPIKPVLDGEPRYENI 276
Cdd:pfam13204 160 WRAMAEGIKEGDPYHLITFHPRGRTSSSDWFHDEPWLDFNMYQSGHAWDGEDNY-RLVEADYAKEPVKPVIDGEPCYEGI 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2550912442 277 PIDFK-SENGRFDDFDVRMTLYQSMFSGACGYTYGCNEVWQMYSDKYSP---MIDAQTTWKESLDLAGACDMIHFRKL 350
Cdd:pfam13204 239 PYGFHdPEEGRWTAEDVRRAAYWSVFAGAAGHTYGANGVWQMHRPGDEPgygVSGPPKSWREALDFPGATQMGYLKKL 316
Collagen_bind_2 pfam12904
Putative collagen-binding domain of a collagenase; This domain is likely to be the ...
 361-450 1.39e-17

Putative collagen-binding domain of a collagenase; This domain is likely to be the collagen-binding domain of a family of bacterial collagenase enzymes. It is the C-terminal part of the PDB:3kzs structure determined from Swiss:Q8A905 (information derived from TOPSAN).


:

Pssm-ID: 463746  Cd Length: 92  Bit Score: 77.65  E-value: 1.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550912442 361 PLQHLIERPEQTDDDYAVAYGGKDYVLFYMPYGHSITVNLsGWTQRKNVRLEWFNPRNGELIFYKNIETSEAFEVVSP-T 439
Cdd:pfam12904   2 PDQSLIAGNNGEGYDRIIATRGKDYALVYTPTGRPFTINL-GKISGKKVKASWFDPRTGEYTPIGEFENKGVQTFTPPgA 80

                          90
                  ....*....|.
gi 2550912442 440 QGRGNDWVLIA 450
Cdd:pfam12904  81 SGRGNDWVLVL 91
 
Name Accession Description Interval E-value
DUF4038 pfam13204
Protein of unknown function (DUF4038); A family of putative cellulases.
 42-350 1.14e-140

Protein of unknown function (DUF4038); A family of putative cellulases.


Pssm-ID: 463808  Cd Length: 320  Bit Score: 405.50  E-value: 1.14e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550912442  42 NGRFLQHTDGTPFLYLGDTAWELIYRLNEPEVELYMENRRAKGFTVIQTVILSELDGSDGIN----RPLINGSPST-PDP 116
Cdd:pfam13204   1 NGRYLVHADGKPFFWLGDTAWELFHRLTREEAEYYLDDRAEQGFNVIQAVVLAELDGLTSPNaygdLPLIDGDPFTqPNE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550912442 117 DYFKWVDRVLEIAGEKGLYVGLLPTWGDKVDKQWGAGPEIFDEANAREYGRWLGRRYADTPNIIWIIGGDRSGEGkNFTV 196
Cdd:pfam13204  81 AYFDHVDYIVDKAAEKGIYIALVPTWGDNVKDGWGGGPEIFNPENAKAYGRFLGARYKDFPNIIWILGGDRDGDE-DREV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550912442 197 WKAMAEGIKECDKRHLMTCHPQGEHSSSFWFHDETWLDFNMFQSGHAQRDYAIYrRLLLNDLQKQPIKPVLDGEPRYENI 276
Cdd:pfam13204 160 WRAMAEGIKEGDPYHLITFHPRGRTSSSDWFHDEPWLDFNMYQSGHAWDGEDNY-RLVEADYAKEPVKPVIDGEPCYEGI 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2550912442 277 PIDFK-SENGRFDDFDVRMTLYQSMFSGACGYTYGCNEVWQMYSDKYSP---MIDAQTTWKESLDLAGACDMIHFRKL 350
Cdd:pfam13204 239 PYGFHdPEEGRWTAEDVRRAAYWSVFAGAAGHTYGANGVWQMHRPGDEPgygVSGPPKSWREALDFPGATQMGYLKKL 316
Collagen_bind_2 pfam12904
Putative collagen-binding domain of a collagenase; This domain is likely to be the ...
 361-450 1.39e-17

Putative collagen-binding domain of a collagenase; This domain is likely to be the collagen-binding domain of a family of bacterial collagenase enzymes. It is the C-terminal part of the PDB:3kzs structure determined from Swiss:Q8A905 (information derived from TOPSAN).


Pssm-ID: 463746  Cd Length: 92  Bit Score: 77.65  E-value: 1.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550912442 361 PLQHLIERPEQTDDDYAVAYGGKDYVLFYMPYGHSITVNLsGWTQRKNVRLEWFNPRNGELIFYKNIETSEAFEVVSP-T 439
Cdd:pfam12904   2 PDQSLIAGNNGEGYDRIIATRGKDYALVYTPTGRPFTINL-GKISGKKVKASWFDPRTGEYTPIGEFENKGVQTFTPPgA 80

                          90
                  ....*....|.
gi 2550912442 440 QGRGNDWVLIA 450
Cdd:pfam12904  81 SGRGNDWVLVL 91
COG3934 COG3934
Endo-1,4-beta-mannosidase [Carbohydrate transport and metabolism];
115-214 2.87e-04

Endo-1,4-beta-mannosidase [Carbohydrate transport and metabolism];


Pssm-ID: 443135 [Multi-domain]  Cd Length: 331  Bit Score: 42.65  E-value: 2.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550912442 115 DPDYFKWVDRVLEIAGEKGLYV--GLLPTW------GDKVDKQWGAGPE---IFDEANAREYGRW----LGRRYADTPNI 179
Cdd:COG3934    63 NEEALERLDYFLDAAAERGLKVvlTLFNNWwsghmsGYNWLPSWVGGWHrrnFYTDPEAVEAQKAyvrtLANRYKDDPAI 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2550912442 180 I-WIIG-----GDRSGEGKNFTVW-KAMAEGIKECDKRHLMT 214
Cdd:COG3934   143 LgWELGneprnFGDPASPEAALAWlREMAAAIKSLDPNHLVS 184
 
Name Accession Description Interval E-value
DUF4038 pfam13204
Protein of unknown function (DUF4038); A family of putative cellulases.
 42-350 1.14e-140

Protein of unknown function (DUF4038); A family of putative cellulases.


Pssm-ID: 463808  Cd Length: 320  Bit Score: 405.50  E-value: 1.14e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550912442  42 NGRFLQHTDGTPFLYLGDTAWELIYRLNEPEVELYMENRRAKGFTVIQTVILSELDGSDGIN----RPLINGSPST-PDP 116
Cdd:pfam13204   1 NGRYLVHADGKPFFWLGDTAWELFHRLTREEAEYYLDDRAEQGFNVIQAVVLAELDGLTSPNaygdLPLIDGDPFTqPNE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550912442 117 DYFKWVDRVLEIAGEKGLYVGLLPTWGDKVDKQWGAGPEIFDEANAREYGRWLGRRYADTPNIIWIIGGDRSGEGkNFTV 196
Cdd:pfam13204  81 AYFDHVDYIVDKAAEKGIYIALVPTWGDNVKDGWGGGPEIFNPENAKAYGRFLGARYKDFPNIIWILGGDRDGDE-DREV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550912442 197 WKAMAEGIKECDKRHLMTCHPQGEHSSSFWFHDETWLDFNMFQSGHAQRDYAIYrRLLLNDLQKQPIKPVLDGEPRYENI 276
Cdd:pfam13204 160 WRAMAEGIKEGDPYHLITFHPRGRTSSSDWFHDEPWLDFNMYQSGHAWDGEDNY-RLVEADYAKEPVKPVIDGEPCYEGI 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2550912442 277 PIDFK-SENGRFDDFDVRMTLYQSMFSGACGYTYGCNEVWQMYSDKYSP---MIDAQTTWKESLDLAGACDMIHFRKL 350
Cdd:pfam13204 239 PYGFHdPEEGRWTAEDVRRAAYWSVFAGAAGHTYGANGVWQMHRPGDEPgygVSGPPKSWREALDFPGATQMGYLKKL 316
Collagen_bind_2 pfam12904
Putative collagen-binding domain of a collagenase; This domain is likely to be the ...
 361-450 1.39e-17

Putative collagen-binding domain of a collagenase; This domain is likely to be the collagen-binding domain of a family of bacterial collagenase enzymes. It is the C-terminal part of the PDB:3kzs structure determined from Swiss:Q8A905 (information derived from TOPSAN).


Pssm-ID: 463746  Cd Length: 92  Bit Score: 77.65  E-value: 1.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550912442 361 PLQHLIERPEQTDDDYAVAYGGKDYVLFYMPYGHSITVNLsGWTQRKNVRLEWFNPRNGELIFYKNIETSEAFEVVSP-T 439
Cdd:pfam12904   2 PDQSLIAGNNGEGYDRIIATRGKDYALVYTPTGRPFTINL-GKISGKKVKASWFDPRTGEYTPIGEFENKGVQTFTPPgA 80

                          90
                  ....*....|.
gi 2550912442 440 QGRGNDWVLIA 450
Cdd:pfam12904  81 SGRGNDWVLVL 91
COG3934 COG3934
Endo-1,4-beta-mannosidase [Carbohydrate transport and metabolism];
115-214 2.87e-04

Endo-1,4-beta-mannosidase [Carbohydrate transport and metabolism];


Pssm-ID: 443135 [Multi-domain]  Cd Length: 331  Bit Score: 42.65  E-value: 2.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550912442 115 DPDYFKWVDRVLEIAGEKGLYV--GLLPTW------GDKVDKQWGAGPE---IFDEANAREYGRW----LGRRYADTPNI 179
Cdd:COG3934    63 NEEALERLDYFLDAAAERGLKVvlTLFNNWwsghmsGYNWLPSWVGGWHrrnFYTDPEAVEAQKAyvrtLANRYKDDPAI 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2550912442 180 I-WIIG-----GDRSGEGKNFTVW-KAMAEGIKECDKRHLMT 214
Cdd:COG3934   143 LgWELGneprnFGDPASPEAALAWlREMAAAIKSLDPNHLVS 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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