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Conserved domains on  [gi|2551177063|ref|WP_302368950|]
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TonB-dependent receptor [Bacteroides clarus]

Protein Classification

SusC/RagA family TonB-linked outer membrane protein( domain architecture ID 11499350)

SusC/RagA family TonB-linked outer membrane protein might act as a TonB-dependent receptor similar to Bacteroides thetaiotaomicron starch-utilization system protein C (SusC), which mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation

CATH:  1.25.40.390
Gene Ontology:  GO:0009279|GO:0016020
PubMed:  15111112|28077872|11717282|17965357

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 28-1018 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


:

Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 871.91  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063   28 VTGVVSDAQG-SLIGVNVHVKGGTTGVITDTNGKYSIEVPASATLVFSYIGYVEQELKVGNKRVINVTLVEDSELLDEVV 106
Cdd:TIGR04056    3 VTGVVVDETGePLIGASVVVKGTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGQKNLNITLKEDTQELDEVV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  107 VVGYGYQRKSDVATSVASVKTDEMKSFPAGNVGDMLRGRVAGVNVTSASGRPGSAPEITIRGNRSISAQNTPLYVIDGsV 186
Cdd:TIGR04056   83 VVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGGDAEIWIRGISSFGGNNSPLYVIDG-V 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  187 SDGEEFSTLSAESIESIEILKDAASQAIYGARASDGVILVTTKRGAQGKMEVNYNGYVGIQSLWRNFDFYSPEEYVMLRR 266
Cdd:TIGR04056  162 PRDNGLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKPKISYNAEFGFSTPTRLPEMLNAYEYAELYN 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  267 EAMANDKgiiDAREMSISealsdDVMKEVWASGQF------VDWEDLMLK-NALYQNHDITVRGGNDKLRVSAGLNYFDQ 339
Cdd:TIGR04056  242 EALLNRG---SSPPDIYT-----DEEIEAYRNGLDpdlypnTDWQDEIFKrTAFNQRHNLSVSGGTEKARYYVSLGYYNE 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  340 DGMVTTgSGYQKAAFRLNVDYKVKKWINFGVNTSYALTKSEREDGN-------FTEFITRTPLAK-VYEEDGTYTKYINS 411
Cdd:TIGR04056  314 EGILKN-SDYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYNNPGGStsniwgaLMLFPRGTPYSTpPVYSDGYYPAYNSG 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  412 ANDV-NPLYRAQNYNREIKNNSYRVNLFLELKPFKGFNYRL-----NTSFYNRQQEDGEAKKTDYPGGG-ATAKLANNEK 484
Cdd:TIGR04056  393 NTSLqNPYALLNRGYNENERNRLNGNASLEQKITKGLKLKGtfsydYSNYKNKKYYKNPYYYNATGGANnGYYSESNSRS 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  485 RSYLIENIFTYDVPFrdKNHKLVLTAVQSVDHTQSKELGYSTASLPvdmgwdFIANGEFSGKPVRTFSENNLVSFMGRAS 564
Cdd:TIGR04056  473 RNYYLEATLNYNRTF--GKHNVSALLGYSQQENKSSSYGGLLDDLP------SLDAGTSDASVSGSDSEYRLQSLFGRAT 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  565 YTLMDKYIMNIAVRRDGSSRFGKNNKWGTFPSIALAWRINQEEFLRNV-SWIDNLKLRLSYGIVGNQNGIGNYTTLGL-- 641
Cdd:TIGR04056  545 YSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKKLkKWLSFLKLRASYGIVGNDNIGDRYPYLSLyn 624

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  642 ANEYRYEFGDNMYMGY--LPGKELSNPNLKWEQSRTTNVGVDFAFFKNRLSGTIEYYQTRTTDLLVKREINSVLGYENML 719
Cdd:TIGR04056  625 LGDGGYNFGTNNGTSVtgITESRYGNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDYYYKKTKDILQSRSLPSVTGYSSPY 704

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  720 DNLGETKSHGVDINISGDVIRTKDLTWSLGANFSHYANEIVKIddqvDENGKPLSQPGNKWFVGEPINVYYNYVPDGIYQ 799
Cdd:TIGR04056  705 ANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILEL----DEGAYLPVKYPYISKEGGPIGQIYGYIADGLFK 780

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  800 YEDFDIKRNpyneleytlkptidtdgdgiadkalsreDDVKPGSVKIKDINGDGKINADDRTPI--SKDPDFTLSLNTSL 877
Cdd:TIGR04056  781 DDDSPKQTF----------------------------GNVRPGDIKYKDVNGDGKIDDDDRVPIgySNTPDLTYGFGNSF 832

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  878 KWKGFDFYMDWYGVSGRKIQNAYL-NESNSGGSLQGKLNGIKVNYWTPFNPSNEFPRPSH----NTNVPYHGALAIQDAS 952
Cdd:TIGR04056  833 SYKGFDLSALFQGSGGGDVFNDGRgFYPFNGGDWGNVLKIVADNRWTPENPNADYPRLSYgdsnNSNNYQASTRWLEDGS 912

                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2551177063  953 YIRLRTLQLGYTFPTEWIKHISLSRLRVYATATNLLTFTDFKSYSPELTP---GAYPESRQYVFGINVS 1018
Cdd:TIGR04056  913 YLRLKNLTLGYTLPKKWLKKIGISNLRVYFSGQNLFTFSKYKGWDPELQGndgGAYPLQRTFSFGVNLT 981
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 28-1018 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 871.91  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063   28 VTGVVSDAQG-SLIGVNVHVKGGTTGVITDTNGKYSIEVPASATLVFSYIGYVEQELKVGNKRVINVTLVEDSELLDEVV 106
Cdd:TIGR04056    3 VTGVVVDETGePLIGASVVVKGTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGQKNLNITLKEDTQELDEVV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  107 VVGYGYQRKSDVATSVASVKTDEMKSFPAGNVGDMLRGRVAGVNVTSASGRPGSAPEITIRGNRSISAQNTPLYVIDGsV 186
Cdd:TIGR04056   83 VVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGGDAEIWIRGISSFGGNNSPLYVIDG-V 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  187 SDGEEFSTLSAESIESIEILKDAASQAIYGARASDGVILVTTKRGAQGKMEVNYNGYVGIQSLWRNFDFYSPEEYVMLRR 266
Cdd:TIGR04056  162 PRDNGLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKPKISYNAEFGFSTPTRLPEMLNAYEYAELYN 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  267 EAMANDKgiiDAREMSISealsdDVMKEVWASGQF------VDWEDLMLK-NALYQNHDITVRGGNDKLRVSAGLNYFDQ 339
Cdd:TIGR04056  242 EALLNRG---SSPPDIYT-----DEEIEAYRNGLDpdlypnTDWQDEIFKrTAFNQRHNLSVSGGTEKARYYVSLGYYNE 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  340 DGMVTTgSGYQKAAFRLNVDYKVKKWINFGVNTSYALTKSEREDGN-------FTEFITRTPLAK-VYEEDGTYTKYINS 411
Cdd:TIGR04056  314 EGILKN-SDYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYNNPGGStsniwgaLMLFPRGTPYSTpPVYSDGYYPAYNSG 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  412 ANDV-NPLYRAQNYNREIKNNSYRVNLFLELKPFKGFNYRL-----NTSFYNRQQEDGEAKKTDYPGGG-ATAKLANNEK 484
Cdd:TIGR04056  393 NTSLqNPYALLNRGYNENERNRLNGNASLEQKITKGLKLKGtfsydYSNYKNKKYYKNPYYYNATGGANnGYYSESNSRS 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  485 RSYLIENIFTYDVPFrdKNHKLVLTAVQSVDHTQSKELGYSTASLPvdmgwdFIANGEFSGKPVRTFSENNLVSFMGRAS 564
Cdd:TIGR04056  473 RNYYLEATLNYNRTF--GKHNVSALLGYSQQENKSSSYGGLLDDLP------SLDAGTSDASVSGSDSEYRLQSLFGRAT 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  565 YTLMDKYIMNIAVRRDGSSRFGKNNKWGTFPSIALAWRINQEEFLRNV-SWIDNLKLRLSYGIVGNQNGIGNYTTLGL-- 641
Cdd:TIGR04056  545 YSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKKLkKWLSFLKLRASYGIVGNDNIGDRYPYLSLyn 624

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  642 ANEYRYEFGDNMYMGY--LPGKELSNPNLKWEQSRTTNVGVDFAFFKNRLSGTIEYYQTRTTDLLVKREINSVLGYENML 719
Cdd:TIGR04056  625 LGDGGYNFGTNNGTSVtgITESRYGNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDYYYKKTKDILQSRSLPSVTGYSSPY 704

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  720 DNLGETKSHGVDINISGDVIRTKDLTWSLGANFSHYANEIVKIddqvDENGKPLSQPGNKWFVGEPINVYYNYVPDGIYQ 799
Cdd:TIGR04056  705 ANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILEL----DEGAYLPVKYPYISKEGGPIGQIYGYIADGLFK 780

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  800 YEDFDIKRNpyneleytlkptidtdgdgiadkalsreDDVKPGSVKIKDINGDGKINADDRTPI--SKDPDFTLSLNTSL 877
Cdd:TIGR04056  781 DDDSPKQTF----------------------------GNVRPGDIKYKDVNGDGKIDDDDRVPIgySNTPDLTYGFGNSF 832

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  878 KWKGFDFYMDWYGVSGRKIQNAYL-NESNSGGSLQGKLNGIKVNYWTPFNPSNEFPRPSH----NTNVPYHGALAIQDAS 952
Cdd:TIGR04056  833 SYKGFDLSALFQGSGGGDVFNDGRgFYPFNGGDWGNVLKIVADNRWTPENPNADYPRLSYgdsnNSNNYQASTRWLEDGS 912

                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2551177063  953 YIRLRTLQLGYTFPTEWIKHISLSRLRVYATATNLLTFTDFKSYSPELTP---GAYPESRQYVFGINVS 1018
Cdd:TIGR04056  913 YLRLKNLTLGYTLPKKWLKKIGISNLRVYFSGQNLFTFSKYKGWDPELQGndgGAYPLQRTFSFGVNLT 981
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
102-783 1.82e-56

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 207.37  E-value: 1.82e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  102 LDEVVVVGYG-YQRKSDVATSVASVKTDEMKSFPAGNVGDMLRgRVAGVNVTSASGRPGSapeITIRGnrSISAQNTPLY 180
Cdd:COG1629      1 LEEVVVTATRtDESLQDVPGSVSVISREQLEDQPATDLGDLLR-RVPGVSVTSAGGGAGQ---ISIRG--FGGGGNRVLV 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  181 VIDG-----SVSDGEEFSTLSAESIESIEILKDAASqAIYGARASDGVILVTTKRGAQGKmEVNYNGYVGiqslwrnfdf 255
Cdd:COG1629     75 LVDGvplndPSGGDGGLSYIDPEDIERVEVLRGPSS-ALYGSGALGGVINIVTKKPKDGK-GGEVSASYG---------- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  256 yspeeyvmlrreamandkgiidaremsisealSDDvmkevwasgqfvdwedlmlknalYQNHDITVRGGNDKLRVSAGLN 335
Cdd:COG1629    143 --------------------------------SYG-----------------------TYRASLSLSGGNGKLAYRLSAS 167

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  336 YFDQDGMVTtGSGYQKAAFRLNVDYKVKKWINFGVNTSYALTKSEREDGNFTEFITRTPlakvyeedgtytkyiNSANDV 415
Cdd:COG1629    168 YRDSDGYRD-NSDSDRYNLRAKLGYQLGDDTRLTLSASYSDSDQDSPGYLTLAALRPRG---------------AMDDGT 231

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  416 NPLYRAQNynreiKNNSYRVNLFLELKPF-KGFNYRLNTsFYNRQQEDGEAKKTDYPGGGATAKLANNEKRSYLIENIFT 494
Cdd:COG1629    232 NPYSNDTD-----DNTRDRYSLSLEYEHLgDGLKLSASA-YYRYDDTDLDSDFTPTPADGGTLEQTDFDNRTYGLELRLT 305

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  495 YDVPFrDKNHKLVLTAvqSVDHTQSKELGYstaslPVDMGWDFIANgefSGKPVRTFSENNLVSFMGRASYTLMDKYIMN 574
Cdd:COG1629    306 YDLGF-GGKHTLLVGL--DYQRQDLDGSGY-----PLDLGSGSLPT---LTSGADDDGTTTSLALYAQDTYKLTDKLTLT 374

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  575 IAVRRDGSSRFGKN------------NKWGTFPSIALAWRINqeeflrnvswiDNLKLRLSYGIVgnqngignyttlgla 642
Cdd:COG1629    375 AGLRYDYVSYDVDDtvtgtdsasgsrSYSAFSPSLGLTYQLS-----------PNLSLYASYSRG--------------- 428

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  643 neYRYEFGDNMYMGYLPGKELSNPNLKWEQSRTTNVGVDFAFFKNRLSGTIEYYQTRTTDLLVKREINSVLGYENMLDNL 722
Cdd:COG1629    429 --FRAPTFGELYANGTDPYSVGNPDLKPETSTNYELGLRYRLLDGRLSLSLALFYSDVDNEILSVPLPNDSGFSTYYTNA 506

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2551177063  723 GETKSHGVDINISGDVIRtkdlTWSLGANFSHYANEIVKIDD-QVDENGKPLSQ-PGNKWFVG 783
Cdd:COG1629    507 GKARSYGVELELSYQLTP----GLSLNASYSYTDAKFDDDTDgSADLDGNRLPGvPPLTANLG 565
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 121-775 7.80e-20

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 94.83  E-value: 7.80e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  121 SVASVKTDEMKSFPAGNVGDMLRgRVAGVNVTSASGrpGSAPEITIRGnrsISAQNTpLYVIDG------SVSDGEEFST 194
Cdd:cd01347      1 SVSVITAEDIEKQPATSLADLLR-RIPGVSVTRGGG--GGGSTISIRG---FGPDRT-LVLVDGlplassNYGRGVDLNT 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  195 LSAESIESIEILKDAASqAIYGARASDGVILVTTKRgAQGKMEVNYNGYVGIQSLWRNFdfyspeeyvmlrreamanDKG 274
Cdd:cd01347     74 IPPELIERVEVLKGPSS-ALYGSGAIGGVVNIITKR-PTDEFGGSVTAGYGSDNSGSSG------------------GGG 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  275 IidaremSISEALSDDVMKEVWASGQFVD-----WEDLMLKNALYQNHDITVRGG---NDKLRVSAGLNYFDQDgmvTTG 346
Cdd:cd01347    134 F------DVSGALADDGAFGARLYGAYRDgdgtiDGDGQADDSDEERYNVAGKLDwrpDDDTRLTLDAGYQDQD---ADG 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  347 SGYQKAAFRLNVDYKVKKWINFGVNTSYALTKSEREDGNFTefitrtplakvyeedgtytkYINSANDVNPLYRAQNYNR 426
Cdd:cd01347    205 PGGTLPANGTGSSLGGGPSSNTNGDRDWDYRDRYRKRASLG--------------------LEHDLNDTGWTLRANLSYS 264

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  427 EIKNNSYrvnlflelkPFKGFNYRLNTSFYNRQQEDGEAKKTDYpgggataklannekrsYLIENIFTYDVPFRDKNHKL 506
Cdd:cd01347    265 YTDNDGD---------PLILNGGNNAAGGDLGRSGYSSERDTTQ----------------LGFDAGLNAPFGTGPVAHTL 319

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  507 VLtavqSVDHTQSKelgystaslpvdmgwdfiangefsgkpvrtfSENNLVSFMGRASYTLMDKYIMNIAVRRDGSSRFG 586
Cdd:cd01347    320 TL----GVEYRREE-------------------------------LDEKQTALYAQDTIELTDDLTLTLGLRYDHYDQDS 364

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  587 KNNKWGTF----------PSIALAWRINqeeflrnvswiDNLKLRLSYGivgnqngignyTTLGLANEYRYEFGDNMYMG 656
Cdd:cd01347    365 KDTIAGGTtakksyshwsPSLGLVYKLT-----------DGLSLYASYS-----------QGFRAPSLGELYGGGSHGGT 422

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  657 YLPGkelsNPNLKWEQSRTTNVGVDFAFFKnRLSGTIEYYQTRTTDLLVKREINSVLGYENMLDNLGETKSHGVDINISG 736
Cdd:cd01347    423 AAVG----NPNLKPEKSKQYELGLKYDPGD-GLTLSAALFRIDIKNEIVSTPTNTGLGLVTVYVNGGKARIRGVELEASY 497

                          650       660       670
                   ....*....|....*....|....*....|....*....
gi 2551177063  737 DVIRtkdlTWSLGANFSHYANEIVKIDDqvDENGKPLSQ 775
Cdd:cd01347    498 DLTD----GLGLTGSYTYTDTEVKRTDG--ATTGNRLPG 530
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 28-107 5.93e-19

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 82.25  E-value: 5.93e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063   28 VTGVVSDAQG--SLIGVNVHVKGGTTGVITDTNGKYSIEVPAS--ATLVFSYIGYVEQELKV----GNKRVINVTLVEDS 99
Cdd:pfam13715    1 ISGTVVDENTgePLPGATVYVKGTTKGTVTDADGNFELKNLPAgtYTLVVSFVGYKTQEKKVtvsnDNTLDVNFLLKEDA 80


                   ....*...
gi 2551177063  100 ELLDEVVV 107
Cdd:pfam13715   81 LLLDEVVV 88
PRK13486 PRK13486
TonB-dependent receptor;
103-333 2.11e-09

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 61.58  E-value: 2.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  103 DEVVVVGYGYQRK-SDVATSVASVKTDEMKSFPAGNVGDMLRGrVAGVNVTSASGRPGSApEITIRGnrsISAQNTpLYV 181
Cdd:PRK13486    26 DVMIVSASGYEKKlTNAAASVSVISQEELQSSQYHDLAEALRS-VEGVDVESGTGKTGGL-EISIRG---MPASYT-LIL 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  182 IDGSVSDGEE------FSTLSA------ESIESIEILKDAASqAIYGARASDGVILVTTKRGAQgKMEVNYNGYVGIQ-- 247
Cdd:PRK13486   100 IDGVRQGGSSdvtpngFSAMNTgfmpplAAIERIEVIRGPMS-TLYGSDAMGGVVNIITRKNAD-KWLSSVNAGLNLQes 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  248 SLWRN---FDFYSPEEyvMLRREAMANDKGIIDAREMSISEALSDDVMKEV----------------W-ASGQFVDWEDL 307
Cdd:PRK13486   178 NKWGNssqFNFWSSGP--LVDDSVSLQVRGSTQQRQGSSVTSLSDTAATRIpyptesqnynlgarldWkASEQDVLWFDM 255

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 2551177063  308 MLKNALYQNHD---ITVRGGNDKL------RVSAG 333
Cdd:PRK13486   256 DTTRQRYDNRDgqlGSLTGGYDRTlryernKISAG 290
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 28-1018 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 871.91  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063   28 VTGVVSDAQG-SLIGVNVHVKGGTTGVITDTNGKYSIEVPASATLVFSYIGYVEQELKVGNKRVINVTLVEDSELLDEVV 106
Cdd:TIGR04056    3 VTGVVVDETGePLIGASVVVKGTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGQKNLNITLKEDTQELDEVV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  107 VVGYGYQRKSDVATSVASVKTDEMKSFPAGNVGDMLRGRVAGVNVTSASGRPGSAPEITIRGNRSISAQNTPLYVIDGsV 186
Cdd:TIGR04056   83 VVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGGDAEIWIRGISSFGGNNSPLYVIDG-V 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  187 SDGEEFSTLSAESIESIEILKDAASQAIYGARASDGVILVTTKRGAQGKMEVNYNGYVGIQSLWRNFDFYSPEEYVMLRR 266
Cdd:TIGR04056  162 PRDNGLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKPKISYNAEFGFSTPTRLPEMLNAYEYAELYN 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  267 EAMANDKgiiDAREMSISealsdDVMKEVWASGQF------VDWEDLMLK-NALYQNHDITVRGGNDKLRVSAGLNYFDQ 339
Cdd:TIGR04056  242 EALLNRG---SSPPDIYT-----DEEIEAYRNGLDpdlypnTDWQDEIFKrTAFNQRHNLSVSGGTEKARYYVSLGYYNE 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  340 DGMVTTgSGYQKAAFRLNVDYKVKKWINFGVNTSYALTKSEREDGN-------FTEFITRTPLAK-VYEEDGTYTKYINS 411
Cdd:TIGR04056  314 EGILKN-SDYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYNNPGGStsniwgaLMLFPRGTPYSTpPVYSDGYYPAYNSG 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  412 ANDV-NPLYRAQNYNREIKNNSYRVNLFLELKPFKGFNYRL-----NTSFYNRQQEDGEAKKTDYPGGG-ATAKLANNEK 484
Cdd:TIGR04056  393 NTSLqNPYALLNRGYNENERNRLNGNASLEQKITKGLKLKGtfsydYSNYKNKKYYKNPYYYNATGGANnGYYSESNSRS 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  485 RSYLIENIFTYDVPFrdKNHKLVLTAVQSVDHTQSKELGYSTASLPvdmgwdFIANGEFSGKPVRTFSENNLVSFMGRAS 564
Cdd:TIGR04056  473 RNYYLEATLNYNRTF--GKHNVSALLGYSQQENKSSSYGGLLDDLP------SLDAGTSDASVSGSDSEYRLQSLFGRAT 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  565 YTLMDKYIMNIAVRRDGSSRFGKNNKWGTFPSIALAWRINQEEFLRNV-SWIDNLKLRLSYGIVGNQNGIGNYTTLGL-- 641
Cdd:TIGR04056  545 YSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKKLkKWLSFLKLRASYGIVGNDNIGDRYPYLSLyn 624

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  642 ANEYRYEFGDNMYMGY--LPGKELSNPNLKWEQSRTTNVGVDFAFFKNRLSGTIEYYQTRTTDLLVKREINSVLGYENML 719
Cdd:TIGR04056  625 LGDGGYNFGTNNGTSVtgITESRYGNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDYYYKKTKDILQSRSLPSVTGYSSPY 704

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  720 DNLGETKSHGVDINISGDVIRTKDLTWSLGANFSHYANEIVKIddqvDENGKPLSQPGNKWFVGEPINVYYNYVPDGIYQ 799
Cdd:TIGR04056  705 ANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILEL----DEGAYLPVKYPYISKEGGPIGQIYGYIADGLFK 780

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  800 YEDFDIKRNpyneleytlkptidtdgdgiadkalsreDDVKPGSVKIKDINGDGKINADDRTPI--SKDPDFTLSLNTSL 877
Cdd:TIGR04056  781 DDDSPKQTF----------------------------GNVRPGDIKYKDVNGDGKIDDDDRVPIgySNTPDLTYGFGNSF 832

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  878 KWKGFDFYMDWYGVSGRKIQNAYL-NESNSGGSLQGKLNGIKVNYWTPFNPSNEFPRPSH----NTNVPYHGALAIQDAS 952
Cdd:TIGR04056  833 SYKGFDLSALFQGSGGGDVFNDGRgFYPFNGGDWGNVLKIVADNRWTPENPNADYPRLSYgdsnNSNNYQASTRWLEDGS 912

                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2551177063  953 YIRLRTLQLGYTFPTEWIKHISLSRLRVYATATNLLTFTDFKSYSPELTP---GAYPESRQYVFGINVS 1018
Cdd:TIGR04056  913 YLRLKNLTLGYTLPKKWLKKIGISNLRVYFSGQNLFTFSKYKGWDPELQGndgGAYPLQRTFSFGVNLT 981
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
102-783 1.82e-56

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 207.37  E-value: 1.82e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  102 LDEVVVVGYG-YQRKSDVATSVASVKTDEMKSFPAGNVGDMLRgRVAGVNVTSASGRPGSapeITIRGnrSISAQNTPLY 180
Cdd:COG1629      1 LEEVVVTATRtDESLQDVPGSVSVISREQLEDQPATDLGDLLR-RVPGVSVTSAGGGAGQ---ISIRG--FGGGGNRVLV 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  181 VIDG-----SVSDGEEFSTLSAESIESIEILKDAASqAIYGARASDGVILVTTKRGAQGKmEVNYNGYVGiqslwrnfdf 255
Cdd:COG1629     75 LVDGvplndPSGGDGGLSYIDPEDIERVEVLRGPSS-ALYGSGALGGVINIVTKKPKDGK-GGEVSASYG---------- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  256 yspeeyvmlrreamandkgiidaremsisealSDDvmkevwasgqfvdwedlmlknalYQNHDITVRGGNDKLRVSAGLN 335
Cdd:COG1629    143 --------------------------------SYG-----------------------TYRASLSLSGGNGKLAYRLSAS 167

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  336 YFDQDGMVTtGSGYQKAAFRLNVDYKVKKWINFGVNTSYALTKSEREDGNFTEFITRTPlakvyeedgtytkyiNSANDV 415
Cdd:COG1629    168 YRDSDGYRD-NSDSDRYNLRAKLGYQLGDDTRLTLSASYSDSDQDSPGYLTLAALRPRG---------------AMDDGT 231

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  416 NPLYRAQNynreiKNNSYRVNLFLELKPF-KGFNYRLNTsFYNRQQEDGEAKKTDYPGGGATAKLANNEKRSYLIENIFT 494
Cdd:COG1629    232 NPYSNDTD-----DNTRDRYSLSLEYEHLgDGLKLSASA-YYRYDDTDLDSDFTPTPADGGTLEQTDFDNRTYGLELRLT 305

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  495 YDVPFrDKNHKLVLTAvqSVDHTQSKELGYstaslPVDMGWDFIANgefSGKPVRTFSENNLVSFMGRASYTLMDKYIMN 574
Cdd:COG1629    306 YDLGF-GGKHTLLVGL--DYQRQDLDGSGY-----PLDLGSGSLPT---LTSGADDDGTTTSLALYAQDTYKLTDKLTLT 374

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  575 IAVRRDGSSRFGKN------------NKWGTFPSIALAWRINqeeflrnvswiDNLKLRLSYGIVgnqngignyttlgla 642
Cdd:COG1629    375 AGLRYDYVSYDVDDtvtgtdsasgsrSYSAFSPSLGLTYQLS-----------PNLSLYASYSRG--------------- 428

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  643 neYRYEFGDNMYMGYLPGKELSNPNLKWEQSRTTNVGVDFAFFKNRLSGTIEYYQTRTTDLLVKREINSVLGYENMLDNL 722
Cdd:COG1629    429 --FRAPTFGELYANGTDPYSVGNPDLKPETSTNYELGLRYRLLDGRLSLSLALFYSDVDNEILSVPLPNDSGFSTYYTNA 506

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2551177063  723 GETKSHGVDINISGDVIRtkdlTWSLGANFSHYANEIVKIDD-QVDENGKPLSQ-PGNKWFVG 783
Cdd:COG1629    507 GKARSYGVELELSYQLTP----GLSLNASYSYTDAKFDDDTDgSADLDGNRLPGvPPLTANLG 565
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 94-754 4.39e-49

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 185.06  E-value: 4.39e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063   94 TLVEDSELLDEVVVVGYGYQRK-SDVATSVASVKTDEMKSFPAGNVGDMLRgRVAGVNVTSASGRPGSAPeITIRGnrsI 172
Cdd:COG4771     19 ALAEDATELEEVVVTATRTEQSlSDAPASVSVITAEEIEKLGATDLADALR-LLPGVSVTRSGGRGGSSG-ISIRG---L 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  173 SAQNTpLYVIDG------SVSDGEEFSTLSAESIESIEILKDAASqAIYGARASDGVILVTTKRGA---QGKMEVNYNGY 243
Cdd:COG4771     94 GGDRV-LVLIDGvpvnnpALGGGGDLSYIPPDDIERIEVIRGPAS-ALYGSDAIGGVINIITKKPTdelEGSVSLGYGSN 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  244 vgiqslwrnfdfyspeeyvmlrreamandkgiidaremsisealsddvmkevwasgqfvdwedlmlkNALYQNHDITVRG 323
Cdd:COG4771    172 -------------------------------------------------------------------GNGTYSGSLSLGG 184

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  324 GNDKLRVSAGLNYFDQDGMV-------TTGSGYQKAAFRLNVDYKVKKWINFGVNTSYaltkseredgnftefitrtpla 396
Cdd:COG4771    185 PGDKLSFLLSGSYRDRDGYLdyrnggfVGNSGYERYNLNAKLGYRLSDNHRLSLSGGY---------------------- 242

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  397 kvyeedgTYTKYINSANDVNPLYRAQNYNREIKNNSYRVNLFLELKpfKGFNYRLNTSFYNRQQEDGEakkTDYPGGGAT 476
Cdd:COG4771    243 -------SRQDRDGGPPTLGDTEISSDNAGDRDTTTDRGNYSLRYN--GDLGDNLDLSLYYSRTDRDS---TNGSLGGST 310

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  477 AKLANNEKRSYLIENIFTYDVpfrDKNHKLVLtavqsvdhtqskelgystaslpvdmGWDFI-ANGEFSGKPVRTFSENN 555
Cdd:COG4771    311 GSFSDSDDTTYGLELDLTYPL---GGNHTLTL-------------------------GAEYRyDDLDSSSFLGGADASRD 362

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  556 LVSFMGRASYTLMDKYIMNIAVRRDGSSRFGKNNKWGTFPSIALAWRINqeeflrnvswiDNLKLRLSYGIvgnqngigN 635
Cdd:COG4771    363 TYGLFAQDEWKLTDKLTLTAGLRYDYYSTFGASNYTAFSPRLGLRYDLS-----------DNLTLRASYGR--------G 423

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  636 YTTLGLANeyRYEFGDNMYMGYLPGkelsNPNLKWEQSRTTNVGVDFAFFKNRLSGTIEYYQTRTTDLLVKREINSVLGY 715
Cdd:COG4771    424 FRAPSLAE--LYGSGTGTPGRYVLG----NPDLKPETSDNYELGLEYRLGNGGLSLSLTGFYTDIKDLIVLVPVGPGPGD 497

                          650       660       670
                   ....*....|....*....|....*....|....*....
gi 2551177063  716 ENMLDNLGETKSHGVDINISGDVirTKDLTWSLGANFSH 754
Cdd:COG4771    498 VLQYENVGKARTYGLELELKYRL--GKGLTLTASYTYLD 534
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
105-253 4.91e-31

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 123.44  E-value: 4.91e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  105 VVVVGYGY-QRKSDVATSVASVKTDEMKSFPAGNVGDMLRgRVAGVNVTSaSGRPGSAPEITIRGNRSisaqNTPLYVID 183
Cdd:COG4206      1 VVVTATRLeQSKSDLTGSVTVIDAEELERSGATSLADALR-RVPGVQVSS-SGGPGSAASISIRGLGS----NQTLVLID 74

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2551177063  184 G----SVSDGE-EFSTLSAESIESIEILKDAASqAIYGARASDGVILVTTKRGAQG-KMEVNYN-GYVGIQSLWRNF 253
Cdd:COG4206     75 GvplnDPSLGGvDLSLIPPDDIERIEVLKGAAS-ALYGSDAIGGVINITTKKGKKGfKGSVSASyGSFGTRRLSASL 150
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 121-775 7.80e-20

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 94.83  E-value: 7.80e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  121 SVASVKTDEMKSFPAGNVGDMLRgRVAGVNVTSASGrpGSAPEITIRGnrsISAQNTpLYVIDG------SVSDGEEFST 194
Cdd:cd01347      1 SVSVITAEDIEKQPATSLADLLR-RIPGVSVTRGGG--GGGSTISIRG---FGPDRT-LVLVDGlplassNYGRGVDLNT 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  195 LSAESIESIEILKDAASqAIYGARASDGVILVTTKRgAQGKMEVNYNGYVGIQSLWRNFdfyspeeyvmlrreamanDKG 274
Cdd:cd01347     74 IPPELIERVEVLKGPSS-ALYGSGAIGGVVNIITKR-PTDEFGGSVTAGYGSDNSGSSG------------------GGG 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  275 IidaremSISEALSDDVMKEVWASGQFVD-----WEDLMLKNALYQNHDITVRGG---NDKLRVSAGLNYFDQDgmvTTG 346
Cdd:cd01347    134 F------DVSGALADDGAFGARLYGAYRDgdgtiDGDGQADDSDEERYNVAGKLDwrpDDDTRLTLDAGYQDQD---ADG 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  347 SGYQKAAFRLNVDYKVKKWINFGVNTSYALTKSEREDGNFTefitrtplakvyeedgtytkYINSANDVNPLYRAQNYNR 426
Cdd:cd01347    205 PGGTLPANGTGSSLGGGPSSNTNGDRDWDYRDRYRKRASLG--------------------LEHDLNDTGWTLRANLSYS 264

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  427 EIKNNSYrvnlflelkPFKGFNYRLNTSFYNRQQEDGEAKKTDYpgggataklannekrsYLIENIFTYDVPFRDKNHKL 506
Cdd:cd01347    265 YTDNDGD---------PLILNGGNNAAGGDLGRSGYSSERDTTQ----------------LGFDAGLNAPFGTGPVAHTL 319

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  507 VLtavqSVDHTQSKelgystaslpvdmgwdfiangefsgkpvrtfSENNLVSFMGRASYTLMDKYIMNIAVRRDGSSRFG 586
Cdd:cd01347    320 TL----GVEYRREE-------------------------------LDEKQTALYAQDTIELTDDLTLTLGLRYDHYDQDS 364

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  587 KNNKWGTF----------PSIALAWRINqeeflrnvswiDNLKLRLSYGivgnqngignyTTLGLANEYRYEFGDNMYMG 656
Cdd:cd01347    365 KDTIAGGTtakksyshwsPSLGLVYKLT-----------DGLSLYASYS-----------QGFRAPSLGELYGGGSHGGT 422

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  657 YLPGkelsNPNLKWEQSRTTNVGVDFAFFKnRLSGTIEYYQTRTTDLLVKREINSVLGYENMLDNLGETKSHGVDINISG 736
Cdd:cd01347    423 AAVG----NPNLKPEKSKQYELGLKYDPGD-GLTLSAALFRIDIKNEIVSTPTNTGLGLVTVYVNGGKARIRGVELEASY 497

                          650       660       670
                   ....*....|....*....|....*....|....*....
gi 2551177063  737 DVIRtkdlTWSLGANFSHYANEIVKIDDqvDENGKPLSQ 775
Cdd:cd01347    498 DLTD----GLGLTGSYTYTDTEVKRTDG--ATTGNRLPG 530
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 28-107 5.93e-19

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 82.25  E-value: 5.93e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063   28 VTGVVSDAQG--SLIGVNVHVKGGTTGVITDTNGKYSIEVPAS--ATLVFSYIGYVEQELKV----GNKRVINVTLVEDS 99
Cdd:pfam13715    1 ISGTVVDENTgePLPGATVYVKGTTKGTVTDADGNFELKNLPAgtYTLVVSFVGYKTQEKKVtvsnDNTLDVNFLLKEDA 80


                   ....*...
gi 2551177063  100 ELLDEVVV 107
Cdd:pfam13715   81 LLLDEVVV 88
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 114-223 1.46e-18

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 81.93  E-value: 1.46e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  114 RKSDVATSVASVKTDEMKSFPAGNVGDMLRgRVAGVNVtsASGRPGSAPEITIRGNRSisaqNTPLYVIDG-----SVSD 188
Cdd:pfam07715    1 DLRDTPGSVSVVTAEDIEDQGATNLADALR-GVPGVSV--SSGGGGGGSSISIRGFGS----NRVLVLVDGvplnsGGGG 73

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2551177063  189 GEEFSTLSAESIESIEILKDAASqAIYGARASDGV 223
Cdd:pfam07715   74 SVDLNSIDPEDIERVEVLKGPAS-ALYGSGAIGGV 107
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 381-775 5.91e-17

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 85.21  E-value: 5.91e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  381 REDGNFTEFITRTPLAKVYEEDGTYTKYINSANdvnplYRAQNYNREIKNNSYRVNLFLELKPFKGFNYRLNTSFYNRQQ 460
Cdd:pfam00593   16 TLGYDYSRYTDGLDLGLTLDGYGNDGGYLGDRP-----LYYGRDYSDTDRKRLSLGYDYDLGDGLSWLSTLRLGLRYSSL 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  461 EDGEAKKTDYPGGGATAKLANNEKRSYLIENIFTYDVPFRDKNHKLVLTAVQSVDHTQSKELGYStaslpvdmgwdfIAN 540
Cdd:pfam00593   91 DGDYTSNSSGLSGAGDYLSDDRLYGLYGLDGDLELSLDLSHDLLLGVELRTAGLDYRRLDDDAYD------------PYD 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  541 GEFSGKPVRTFSENNLVSFMGRASYTLMDKYIMNIAVRRDGSSRFGKN----------NKWGTFPSIALAWRINqeeflr 610
Cdd:pfam00593  159 PANPSSSSYSDTTTDSYGLYLQDNIKLTDRLTLTLGLRYDHYSTDGDDgngggdnfsrSYSAFSPRLGLVYKPT------ 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  611 nvswiDNLKLRLSYGIVGNQNGIGNYTTLGLANEYRYEFGdnmymgylpgkelSNPNLKWEQSRTTNVGVDfaFFKNRLS 690
Cdd:pfam00593  233 -----DNLSLYASYSRGFRAPSLGELYGSGSGGGGGAVAG-------------GNPDLKPETSDNYELGLK--YDDGRLS 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  691 GTIEYYQTRTTDLLVKREINSVLGYENM-LDNLGETKSHGVDINISGDVirtkdltWSLGANFSHYANEIVKIDDQVDEN 769
Cdd:pfam00593  293 LSLALFYIDIKNLITSDPDGPGLGGTVYtYTNVGKARIRGVELELSGRL-------WGLGLSGGGYTYTDADDDADADDT 365


                   ....*.
gi 2551177063  770 GKPLSQ 775
Cdd:pfam00593  366 GNPLPN 371
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
97-754 2.17e-12

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 71.11  E-value: 2.17e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063   97 EDSELLDEVVVVGYGYQRKS--DVATSVASVKTDEMKSFPAGNVGDMLRgRVAGVNVTSASGrPGSAPEITIRG---NRS 171
Cdd:COG4772     18 EAATTLETVVVTGSRAAEARlkDVPGSVSVVDREELENQAATSLREVLR-RVPGVNVQEEDG-FGLRPNIGIRGlgpRRS 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  172 isaQNTPLYViDG------SVSDGEEFSTLSAESIESIEILKDAASqAIYGARASDGVILVTTKRGAqgkmevnyngyvg 245
Cdd:COG4772     96 ---RGITLLE-DGipiapaPYGDPAAYYFPDLERMERIEVLRGAAA-LRYGPQTVGGAINFVTRTIP------------- 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  246 iqslwrnfdfyspeeyvmlrreamandkgiiDAREMSISEALsddvmkevwasGQFvdwedlmlknaLYQNHDITVRGGN 325
Cdd:COG4772    158 -------------------------------TAFGGELRVTG-----------GSF-----------GYRRTHASVGGTV 184

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  326 DKLRVSAGLNYFDQDGmvttgsgyqkaaFRLNVDYKVKkwiNFGVNTSYALTksereDGNFTEFItrtpLAKVYEEDGTY 405
Cdd:COG4772    185 GNFGYLVEYSRKRGDG------------FRDNSGFDIN---DFNAKLGYRLS-----DRQELTLK----FQYYDEDANTP 240

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  406 TKYINSANDVNPLYRAQNYNReIKNNSYRVNLFLELKPFKGFnyRLNTSFY----NRQQEDGEAkKTDYPGGGATAKLAN 481
Cdd:COG4772    241 GGLTDAQFDADPRQSYRPADQ-FDTRRTQLSLRYEHQLSDNT--TLTTTAYyndfSRNWYIRQN-TADPNTPGLGLRGNP 316

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  482 NEKRSYLIENIFTYDVPFRDKNHKLVLTAvqSVDHTQSKELGYSTASLPVDMGWDFIANGEFSGKPVRTFSENNLvSFMG 561
Cdd:COG4772    317 RGYRSYGIEPRLTHRFELGGVPHTLEVGL--RYHREEEDRKQYVNTYGQGRSGAGLRRDRRFSADALAAYAQNRF-ELTG 393

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  562 R-----------ASYTLMDKYIMNIAVRRDGSSRFgknNKWgtFPSIALAWRINqeeflrnvswiDNLKLRLSYGivgnq 630
Cdd:COG4772    394 RltltpglryehIRRDRTDRYSTRTGGDDSGSNSY---SEF--LPGLGLLYQLT-----------DNLQLYANVS----- 452

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  631 ngiGNYTTLGlaneyryeFGDnmyMGYLPGkelSNPNLKWEQSRTTNVGVDFAfFKNRLSGTIEYYQTRTTDLLVkrEIN 710
Cdd:COG4772    453 ---RGFEPPT--------FGD---LAYGNG---GNPDLKPEKSWNYELGTRGR-IGNGLSAEVALFYIDYDNELG--SCS 512

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 2551177063  711 SVLGYENMLDNLGETKSHGVDINISGDVIRTKDLTWSLGANFSH 754
Cdd:COG4772    513 AAGGDRSTFTNAGETRHQGLELALDYDLLKGGGLGLPLFAAYTY 556
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 67-775 9.01e-11

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 66.07  E-value: 9.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063   67 ASATLVFSYIGYVEQelkvGNKRVINVTLVEDSELLDEVVVVGYGYQRKSDVATSVASV-KTD----------------E 129
Cdd:COG4773      1 AAALLAGSGLAAAAA----GALAQAAAAAAAEATTLPEVTVTGTAEGTGGYTAKSSSTAtKLDtplretpqsvsvvtrqL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  130 MKSFPAGNVGDMLRgRVAGVNVTSASGrpGSAPEITIRGnrsISAQNtplYVIDGSVSDGEEFSTLSAESIESIEILKDA 209
Cdd:COG4773     77 IEDQGATTLDDALR-NVPGVTVSSYDG--GGRDSFSIRG---FSIDN---YLRDGLPLGGFGGGQPDTANLERVEVLKGP 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  210 ASqAIYGARASDGVILVTTKR---GAQGKMEVNYNgyvgiqslwrNFDFYSPEeyvmlrreamandkgiIDaremsISEA 286
Cdd:COG4773    148 AG-LLYGAGSPGGLVNLVTKRptaEPQGEVSLSAG----------SWDTYRAT----------------AD-----VGGP 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  287 LSDDvmkevwasGQF---VdwedlmlkNALYQNHDITV-RGGNDKLRVSAGLNY-FDQDGMVTTGSGYQKAafrlnvdyk 361
Cdd:COG4773    196 LNED--------GTLryrL--------NAAYEDGDSFRdGVDNRRTLIAPSLDWdLTDDTTLTLGAEYQDD--------- 250

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  362 vkkwinfgvntsyaltkseredgNFTEFITRTPLakvyeeDGTYTKYINSANDvnplyrAQNYNReIKNNSYRVNLFLEL 441
Cdd:COG4773    251 -----------------------DSTGDRGFLPL------DGTLLDLPRSTNL------GEPWDY-YDTETTTLFAELEH 294

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  442 KPFKGFNYRLNTSfYNRQQEDGeakKTDYPGGGATAK---------LANNEKRSYLIENIFTYDVPFRDKNHKLVLtavq 512
Cdd:COG4773    295 RFNDDWSLRANAR-YSDSDRDG---RSAYAYGAPDAAtgtltryasARDGDSRSDSLDANLNGKFETGGLEHTLLV---- 366

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  513 SVDHTQSKELGYSTASLPVDM-GWDFIANGEFSGKPVRTFSENNLVSFMGRASYTLMDKYIMNIAVRRD----------- 580
Cdd:COG4773    367 GADYSRYDSDSDSATAGTINIyNPVYGNLPEPDFDASDTDTTTRQTGLYAQDQISLTDRLSLLLGGRYDwyetdstnrlg 446

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  581 GSSRFGKNNKWGtfPSIALAWRINqeeflrnvswiDNLKLRLSYG-IVGNQNGIGNYTTLglaneyryefgdnmymgylp 659
Cdd:COG4773    447 GSTTSYDDSAFT--PRAGLVYDLT-----------PGLSLYASYSeSFEPQSGADNNGNP-------------------- 493

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  660 gkelsnpnLKWEQSRTTNVGVDFAFFKNRLSGTIEYYQTRTTDLLVkreinSVLGYENMLDNLGETKSHGVDINISGDVI 739
Cdd:COG4773    494 --------LDPETGKQYEAGVKGELFDGRLNATLAVFDITQKNVAT-----TDPDNPNFYVQVGEVRSRGVELELSGELT 560

                          730       740       750
                   ....*....|....*....|....*....|....*.
gi 2551177063  740 RtkdlTWSLGANFSHYANEIVKidDQVDENGKPLSQ 775
Cdd:COG4773    561 P----GLNLIAGYTYTDAKITK--DADALEGKRLTN 590
SusC_RagA_signa TIGR04057
TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model ...
 200-229 1.24e-10

TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model describes a 31-residue signature region of the SusC/RagA family of outer membrane proteins from the Bacteriodetes. While many TonB-dependent outer membrane receptors are associated with siderophore import, this family seems to include generalized nutrient receptors that may convey fairly large oligomers of protein or carbohydrate. This family occurs in high copy numbers in the most abundant species of the human gut microbiome.


Pssm-ID: 274949 [Multi-domain]  Cd Length: 31  Bit Score: 56.82  E-value: 1.24e-10
                           10        20        30
                   ....*....|....*....|....*....|
gi 2551177063  200 IESIEILKDAASQAIYGARASDGVILVTTK 229
Cdd:TIGR04057    2 IESISVLKDASAAAIYGSRGANGVILITTK 31
PRK13486 PRK13486
TonB-dependent receptor;
103-333 2.11e-09

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 61.58  E-value: 2.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  103 DEVVVVGYGYQRK-SDVATSVASVKTDEMKSFPAGNVGDMLRGrVAGVNVTSASGRPGSApEITIRGnrsISAQNTpLYV 181
Cdd:PRK13486    26 DVMIVSASGYEKKlTNAAASVSVISQEELQSSQYHDLAEALRS-VEGVDVESGTGKTGGL-EISIRG---MPASYT-LIL 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  182 IDGSVSDGEE------FSTLSA------ESIESIEILKDAASqAIYGARASDGVILVTTKRGAQgKMEVNYNGYVGIQ-- 247
Cdd:PRK13486   100 IDGVRQGGSSdvtpngFSAMNTgfmpplAAIERIEVIRGPMS-TLYGSDAMGGVVNIITRKNAD-KWLSSVNAGLNLQes 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  248 SLWRN---FDFYSPEEyvMLRREAMANDKGIIDAREMSISEALSDDVMKEV----------------W-ASGQFVDWEDL 307
Cdd:PRK13486   178 NKWGNssqFNFWSSGP--LVDDSVSLQVRGSTQQRQGSSVTSLSDTAATRIpyptesqnynlgarldWkASEQDVLWFDM 255

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 2551177063  308 MLKNALYQNHD---ITVRGGNDKL------RVSAG 333
Cdd:PRK13486   256 DTTRQRYDNRDgqlGSLTGGYDRTlryernKISAG 290
CarboxypepD_reg pfam13620
Carboxypeptidase regulatory-like domain;
27-95 1.16e-08

Carboxypeptidase regulatory-like domain;


Pssm-ID: 433354 [Multi-domain]  Cd Length: 81  Bit Score: 53.05  E-value: 1.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063   27 RVTGVVSDAQGSLI-GVNVHVK----GGTTGVITDTNGKYSIE--VPASATLVFSYIGYVEQE-----LKVGNKRVINVT 94
Cdd:pfam13620    1 TISGTVTDPSGAPVpGATVTVTntdtGTVRTTTTDADGRYRFPglPPGTYTVTVSAPGFKTATrtgvtVTAGQTTTLDVT 80


                   .
gi 2551177063   95 L 95
Cdd:pfam13620   81 L 81
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
117-774 1.22e-07

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 55.65  E-value: 1.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  117 DVATSVASVKTDEMKSFPAGNVGDMLRgRVAGVnvTSASGRPGSAPEITIRGNRSisaqNTPLYViDGSVSDGeeFSTLS 196
Cdd:COG4774      8 DTPQSVTVVTRELIEDQGATSLADALR-NVPGV--TFGAGEGGNGDSFSIRGFSA----SGDIYV-DGLRDPG--QYRRD 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  197 AESIESIEILKDAASqAIYGARASDGVILVTTKRgAQGKMEVNYNGYVGIQSLWR-NFDFyspeeyvmlrreamandkgi 275
Cdd:COG4774     78 TFNLERVEVLKGPAS-VLYGRGSPGGVINLVTKR-PTDEPFTEVTLTYGSDGQRRaTLDV-------------------- 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  276 idaremsiSEALSDD------VMKEvwASGQFVDWEDlmlknalyqNHDITVR-----GGNDKLRVSAGLNYFDQDGMVT 344
Cdd:COG4774    136 --------NGPLGDDlayrlnGMYR--DSDSYRDGVD---------NDRWGIApsltwRLGDRTRLTLDYEYQDDDRTPD 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  345 TGSGYQKAAFRLNVDYKvkkwINFGVNTSYaltkSEREDGNFTefitrtplakvyeedGTYTKYINSANDVNPLYRAQNY 424
Cdd:COG4774    197 YGVPAVANGRPVDVDRS----TFYGQPDDY----SDSETDSAT---------------LRLEHDFNDNWTLRNALRYSDY 253

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  425 NREIKNNSYRVNLflelkpfkgFNYRLNTSFYNRQQEDgeakktdypgggataklannekRSYLIENIFTYDVPFRDKNH 504
Cdd:COG4774    254 DRDYRNTYPTGGN---------ATGTVTRSAYRRDQDN----------------------DTLSNQTDLTGKFDTGGVKH 302

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  505 KLVLTAVQSVDHTQSKELGYSTASLPVDMG--WDFIANGEFSGKPVRTFSENNLVSFMGRASYTLMDKYIMNIAVRRDGS 582
Cdd:COG4774    303 TLLAGVEYSREDSDNARYSGGGTAPTVNLYnpVYGAPVTGPTLGGADNDSRTDTTGLYLQDTISLTDRWSLLAGLRYDRF 382

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  583 SRFGKNNKWGTFPSialawRINQEEFLRNVSwidnlklrLSYGIVGNQNGIGNYTTlglaneyryefgdnmymGYLPGKE 662
Cdd:COG4774    383 DTDYTDRTTGATTS-----SYDDSAFSPRAG--------LVYKPTPNLSLYASYST-----------------SFNPGGG 432

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  663 L-----SNPNLKWEQSRTTNVGVDFAFFKNRLSGTIEYYQTRTTDLLVKREINSvlgyeNMLDNLGETKSHGVDINISGD 737
Cdd:COG4774    433 ApslsnAGQALDPEKSRQYEVGVKWDLLDGRLSLTAALFRIEKTNVRTTDPANP-----GVYVQTGEQRSRGVELEATGE 507

                          650       660       670
                   ....*....|....*....|....*....|....*..
gi 2551177063  738 VIRtkdlTWSLGANFSHYANEIVKiDDQVDENGKPLS 774
Cdd:COG4774    508 LTP----GWSVLAGYTYLDAEITK-SANAANVGNRLP 539
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 117-258 1.71e-06

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 52.03  E-value: 1.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  117 DVATSVASVKTDEMKSFPAGNVGDMLRgRVAGVNVTSASGRpGSAPEITIRG-NRSISAQNTPLyviDG-SVSDGEEFST 194
Cdd:TIGR01783    1 DIPQSVSVITRQELEDQQAGSLSEALQ-RVPGVVVGGSGGT-TQFGNITIRGfGLEVDIDNVYL---DGvPLLSRGNLAI 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2551177063  195 LSAESIESIEILKDAASqAIYGARASDGVILVTTKRgAQGKMEVNYNGYVGIQSLWR-NFDFYSP 258
Cdd:TIGR01783   76 VDPAMVERVEVLRGPAS-LLYGGSAPGGVINIVTKR-PQDEPKGSVTFGAGTRSGYRtAFDLGGP 138
PRK13513 PRK13513
ligand-gated channel protein;
102-234 8.96e-06

ligand-gated channel protein;


Pssm-ID: 184104 [Multi-domain]  Cd Length: 659  Bit Score: 49.77  E-value: 8.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  102 LDEVVVVGYGYQRK-SDVATSVASVKTDEMKSFPAGNVGDMLRGrVAGVNVTSAsgrpGSAPEITIRGnrsISAQNTpLY 180
Cdd:PRK13513    35 TDTMVVTASGFQQRiQDAPASISVVTREQLENKAYRDVTDALKD-VPGVVVTGG----GSTSDISIRG---MAAKYT-LI 105

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2551177063  181 VIDGSV---------SDG---EEFSTLSAESIESIEILKDAASqAIYGARASDGVILVTTKRGAQG 234
Cdd:PRK13513   106 LVDGKRvdtrstrpnSDGsgiEQGWLPPLAAIERIEVVRGPMS-SLYGSDAMGGVINIITRKVQKE 170
PRK13528 PRK13528
outer membrane receptor FepA; Provisional
 92-230 1.82e-05

outer membrane receptor FepA; Provisional


Pssm-ID: 237413 [Multi-domain]  Cd Length: 727  Bit Score: 48.60  E-value: 1.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063   92 NVTLVEDSELLDEVVVVGYGYQR-KSDVATSVASVKtDEMKSFPAGNVGDMLRgRVAGVNVT--SASGRPGSAPEITIRG 168
Cdd:PRK13528    24 SAAESSDDDNGETMVVEATAEQElKQQPGVSIITAE-DIKKRPPVNDLSDIIR-KMPGVNLTgnSASGTRGNNRQIDIRG 101

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2551177063  169 nrsISAQNTpLYVIDG-------SVS---DGEEFST-----LSAESIESIEILKDAASqAIYGARASDGVILVTTKR 230
Cdd:PRK13528   102 ---MGPENT-LILIDGvpvtsrnSVRyswRGERDTRgdtnwVPPEMVERIEVIRGPAA-ARYGSGAAGGVVNIITKR 173
PRK13524 PRK13524
FepA family TonB-dependent siderophore receptor;
134-241 2.77e-05

FepA family TonB-dependent siderophore receptor;


Pssm-ID: 237410 [Multi-domain]  Cd Length: 744  Bit Score: 48.10  E-value: 2.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177063  134 PAGNVGDMLRgRVAGVNVT--SASGRPGSAPEITIRGnrsISAQNTpLYVIDG-------SVSDG--EEFST------LS 196
Cdd:PRK13524    68 PANDVSEIIR-TMPGVNLTgnSTSGQRGNNRQIDIRG---MGPENT-LILIDGkpvssrnSVRYGwrGERDTrgdtnwVP 142

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2551177063  197 AESIESIEILKDAASqAIYGARASDGVILVTTKRGAQ---GKMEVNYN 241
Cdd:PRK13524   143 PEMIERIEVLRGPAA-ARYGNGAAGGVVNIITKKPTGewhGSWNTYFN 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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