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Conserved domains on  [gi|2551177176|ref|WP_302369062|]
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nitroreductase [Bacteroides clarus]

Protein Classification

nitroreductase family protein( domain architecture ID 10002498)

nitroreductase family protein may catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor

CATH:  3.40.109.10|2.20.180.10
EC:  1.-.-.-
Gene Ontology:  GO:0016491
PubMed:  29078300|7601851
SCOP:  3001947

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 5-178 4.50e-43

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


:

Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 141.14  E-value: 4.50e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   5 VLENIKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLtelnEKIKGAFAKSDDTRLqerghsr 84
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELR----ERLAEALAEANQEWV------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  85 tyccyYHAPALIIVSNEPTC------WWAPMDCACALQNIFLAAKSLGIGSCWINQLgqtcDDPDVRAFltqLGIPENHR 158
Cdd:COG0778    70 -----ADAPVLIVVCADPDRsekvpeRYALLDAGIAAQNLLLAARALGLGTCWIGGF----DPEKVREL---LGLPEGEE 137

                         170       180
                  ....*....|....*....|
gi 2551177176 159 VYGCAALCYAPADAPVKDKK 178
Cdd:COG0778   138 PVALLALGYPAEELNPRPRK 157
 
Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 5-178 4.50e-43

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 141.14  E-value: 4.50e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   5 VLENIKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLtelnEKIKGAFAKSDDTRLqerghsr 84
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELR----ERLAEALAEANQEWV------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  85 tyccyYHAPALIIVSNEPTC------WWAPMDCACALQNIFLAAKSLGIGSCWINQLgqtcDDPDVRAFltqLGIPENHR 158
Cdd:COG0778    70 -----ADAPVLIVVCADPDRsekvpeRYALLDAGIAAQNLLLAARALGLGTCWIGGF----DPEKVREL---LGLPEGEE 137

                         170       180
                  ....*....|....*....|
gi 2551177176 159 VYGCAALCYAPADAPVKDKK 178
Cdd:COG0778   138 PVALLALGYPAEELNPRPRK 157
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 9-174 9.77e-42

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 137.33  E-value: 9.77e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   9 IKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAvltelNEKIKGAFaksddtrlqerghsrtycc 88
Cdd:cd02136     2 IKSRRSVRAFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTGKA-----RERLKKAF------------------- 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  89 yYHAPALIIVSNEPTCW-WAPMDCACALQNIFLAAKSLGIGSCWInqlGQTCDDPDVraFLTQLGIPENHRVYGCAALCY 167
Cdd:cd02136    58 -FGAPVALFLTMDKVLGpWSWFDLGAFLQNLMLAAHALGLGTCPQ---GALAGYPDV--VRKELGIPDDEELVCGIALGY 131


                  ....*..
gi 2551177176 168 APADAPV 174
Cdd:cd02136   132 PDPDAPV 138
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 9-165 4.85e-36

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 123.66  E-value: 4.85e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   9 IKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLTELNEKIKGAFAKSDDTRLQERGHSRTYCC 88
Cdd:pfam00881   1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVEPAAALLLLLRRDANLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  89 Y------YHAPALIIVSNEPTC----------WWAPMDCACALQNIFLAAKSLGIGSCWINQlgqtcddPDVRAFLTQLG 152
Cdd:pfam00881  81 LllqdflRGAPVLIVITASLSTylrkaaerayREALLDAGAAAQNLLLAATSLGLGSCPIGG-------FDAAAVRELLG 153

                         170
                  ....*....|...
gi 2551177176 153 IPENHRVYGCAAL 165
Cdd:pfam00881 154 LPDDERLVGLIAV 166
PRK10828 PRK10828
putative oxidoreductase; Provisional
 6-146 3.88e-07

putative oxidoreductase; Provisional


Pssm-ID: 182761  Cd Length: 183  Bit Score: 48.15  E-value: 3.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   6 LENIKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAV--LTELNEkiKGAFAKSDDTRLQERGHS 83
Cdd:PRK10828    4 LELLLNRRSASRLAEPAPTGEQLQNILRAGMRAPDHGSLQPWRFFVIEGEGRerFSALLE--QGAIAAGSDEKAIEKARN 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  84 RTyccyYHAPALIIV-------SNEPTcWWAPMDCACALQNIFLAAKSLGIGSCWinQLGQTCDDPDVRA 146
Cdd:PRK10828   82 AP----FRAPLIITVvakceenHKVPR-WEQEVSAGCAVMAMQMAAVAQGFNGIW--RSGAWTESPVVRE 144
 
Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 5-178 4.50e-43

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 141.14  E-value: 4.50e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   5 VLENIKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLtelnEKIKGAFAKSDDTRLqerghsr 84
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELR----ERLAEALAEANQEWV------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  85 tyccyYHAPALIIVSNEPTC------WWAPMDCACALQNIFLAAKSLGIGSCWINQLgqtcDDPDVRAFltqLGIPENHR 158
Cdd:COG0778    70 -----ADAPVLIVVCADPDRsekvpeRYALLDAGIAAQNLLLAARALGLGTCWIGGF----DPEKVREL---LGLPEGEE 137

                         170       180
                  ....*....|....*....|
gi 2551177176 159 VYGCAALCYAPADAPVKDKK 178
Cdd:COG0778   138 PVALLALGYPAEELNPRPRK 157
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 9-174 9.77e-42

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 137.33  E-value: 9.77e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   9 IKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAvltelNEKIKGAFaksddtrlqerghsrtycc 88
Cdd:cd02136     2 IKSRRSVRAFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTGKA-----RERLKKAF------------------- 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  89 yYHAPALIIVSNEPTCW-WAPMDCACALQNIFLAAKSLGIGSCWInqlGQTCDDPDVraFLTQLGIPENHRVYGCAALCY 167
Cdd:cd02136    58 -FGAPVALFLTMDKVLGpWSWFDLGAFLQNLMLAAHALGLGTCPQ---GALAGYPDV--VRKELGIPDDEELVCGIALGY 131


                  ....*..
gi 2551177176 168 APADAPV 174
Cdd:cd02136   132 PDPDAPV 138
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 9-167 4.28e-36

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 122.79  E-value: 4.28e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   9 IKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAavltelnEKIKGAFAKSDDTRLQerghsrtycc 88
Cdd:cd02062     1 IKTRRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDR-------EKKEKLAKLAAPNQKF---------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  89 YYHAPALIIV--SNEPTCWWAPMDCACALQNIFLAAKSLGIGSCWINqlGQTCDDPDVRAFltqLGIPENHRVYGCAALC 166
Cdd:cd02062    64 IAGAPVVIVVvaDPDKSRPWALEDAGAAAQNLLLAAAALGLGSCWIG--GFDFREDKVREL---LGIPENLRPVALIAIG 138


                  .
gi 2551177176 167 Y 167
Cdd:cd02062   139 Y 139
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 9-165 4.85e-36

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 123.66  E-value: 4.85e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   9 IKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLTELNEKIKGAFAKSDDTRLQERGHSRTYCC 88
Cdd:pfam00881   1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVEPAAALLLLLRRDANLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  89 Y------YHAPALIIVSNEPTC----------WWAPMDCACALQNIFLAAKSLGIGSCWINQlgqtcddPDVRAFLTQLG 152
Cdd:pfam00881  81 LllqdflRGAPVLIVITASLSTylrkaaerayREALLDAGAAAQNLLLAATSLGLGSCPIGG-------FDAAAVRELLG 153

                         170
                  ....*....|...
gi 2551177176 153 IPENHRVYGCAAL 165
Cdd:pfam00881 154 LPDDERLVGLIAV 166
nitroreductase_FeS-like cd02143
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ...
 9-162 1.01e-34

nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.


Pssm-ID: 380319 [Multi-domain]  Cd Length: 187  Bit Score: 120.66  E-value: 1.01e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   9 IKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLTELNEKI--------------KGAFAKSDD 74
Cdd:cd02143     2 LRSRRSIRRYKDKPVPRETLEKLLDIARYAPTGHNSQPVHWLVVDDPEKVRRLAELVidwmrelikedpelAGKLFLDGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  75 TRLQERGH---SRtyccyyHAPALIIVSNEPTCWWAPMDCACALQNIFLAAKSLGIGSCWiNQLGQTC--DDPDVRAFlt 149
Cdd:cd02143    82 VAAWEKGIdviLR------GAPHLVVAHAPKDAPTPPVDCAIALTYLELAAPSLGLGTCW-AGFFTAAanNYPPLREA-- 152

                         170
                  ....*....|...
gi 2551177176 150 qLGIPENHRVYGC 162
Cdd:cd02143   153 -LGLPEGHKVGGA 164
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 9-177 3.41e-34

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 118.47  E-value: 3.41e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   9 IKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLtelnEKIKGAFaksddtrlqerghsrTYCC 88
Cdd:cd02150     1 ILTRRSIRKYTDKPVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVTDREKL----DKIAEAH---------------PYGK 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  89 YYH-APALIIVSNEPT------CWwaPMDCACALQNIFLAAKSLGIGSCWinqLGQTCDDPDVRAFLTQLGIPENHRVYG 161
Cdd:cd02150    62 MLKeAPLAIVVCGDPSkekapgYW--VQDCSAATENILLAAHALGLGAVW---LGVYPFEERVKAIREILNIPENIIPFC 136

                         170
                  ....*....|....*..
gi 2551177176 162 CAALCYaPADAPV-KDK 177
Cdd:cd02150   137 VIALGY-PAEEKEpKDR 152
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 4-159 3.62e-31

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 110.17  E-value: 3.62e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   4 EVLENIKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLtelnEKIKGAfaksddtrlqerghs 83
Cdd:cd20609     1 DFLELAKKRYSVRKFSDKPVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEAL----EKLAKA--------------- 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  84 rtYCCYYHAPALIIV-SNEPTCWWAP--------MDCACALQNIFLAAKSLGIGSCWINQLgqtcdDPD-VRAfltQLGI 153
Cdd:cd20609    62 --TPRFFGAPLVIVVcYDKDESWKRPydgkdsgdIDAAIVATHMMLAATELGLGTCWVGNF-----DPEkVRE---AFNL 131


                  ....*.
gi 2551177176 154 PENHRV 159
Cdd:cd20609   132 PENLEP 137
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 6-167 1.46e-30

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 108.58  E-value: 1.46e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   6 LENIKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLTELNEK---IKGAFAKsddtrlqergh 82
Cdd:cd20608     1 FEAIKTRRSVRRFSDKPVEEEKLEKILEAARLAPSWANKQCWRFIVVTDKETLSELAKKespSNGWLKD----------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  83 srtyccyyhAPALIIVSNEPT-CWWAP------MDCACALQNIFLAAKSLGIGSCWINQLgqtcDDPDVRAfltQLGIPE 155
Cdd:cd20608    70 ---------APVIIVVCADPKdSGWLNgqnyylVDAAIAMQNLMLAATDLGLGTCWIGAF----DEKKVKE---ILGIPE 133

                         170
                  ....*....|..
gi 2551177176 156 NHRVYGCAALCY 167
Cdd:cd20608   134 NIRVVALTPLGY 145
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 9-159 4.15e-30

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 108.00  E-value: 4.15e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   9 IKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLTELNEKIKGAFAKSDDtrlqerghsrtycc 88
Cdd:cd02151     3 LKKRRSIRKYTDEPIEEEKLEEILEAALLAPSSRNSRPVEFIVVDDKETLKKLSECKPHGSAFLKG-------------- 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2551177176  89 yyhAPALIIV-SNEPTC-WWAPmDCACALQNIFLAAKSLGIGSCWIN------QLGQTCDDpDVRAFltqLGIPENHRV 159
Cdd:cd02151    69 ---APAAIVVlADTEKSdTWIE-DASIAATYIQLAAESLGLGSCWIQirnretQDGKTAEE-YVREL---LGIPENYRV 139
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 5-173 2.29e-28

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 103.70  E-value: 2.29e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   5 VLENIKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAavltELNEKIKGAFAKSDdtrlqerghsr 84
Cdd:cd02139     1 VYEAIKKRRSIRKYKPTPVEEEKLLRILEAARLAPSAKNRQPWRFIVVKDK----ELKEKLAEAANGQK----------- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  85 tycCYYHAPALI-IVSNEPTCW------WAPMDCACALQNIFLAAKSLGIGSCWINQLgqtcDDPDVRAFltqLGIPENH 157
Cdd:cd02139    66 ---FIAEAPVVIvACADPSESGmgcgkpYYLVDVAIAMEHLVLAATEEGLGTCWIGAF----DEDKVKEI---LGIPEEY 135

                         170
                  ....*....|....*.
gi 2551177176 158 RVYGCAALCYaPADAP 173
Cdd:cd02139   136 RVVALTPLGY-PAEEP 150
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 9-152 2.98e-26

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 98.50  E-value: 2.98e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   9 IKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLTELNEKIKgafAKSDD-TRLQE-------- 79
Cdd:cd20610     1 IKKRRSIRKFKPDPVPKEDIEKILEAANWAPSGMNRQNWEFVVVKGGEKIEKIGISIK---KKNEEiARLLEkvfaekpi 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  80 --RGHSRTYCCYYHAPALIIVSNEPTcwwAPMD--------CACALQNIFLAAKSLGIGSCWINqlGQTCDDPDVRAFLT 149
Cdd:cd20610    78 rfRKFRRFFTLFGGAPVLVVVYTEPY---KPPEerkpdlqsVSAAIQNLLLAAHALGLGTCWMT--GPLYAEDEIEEILE 152


                  ...
gi 2551177176 150 QLG 152
Cdd:cd20610   153 IPD 155
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 6-159 4.57e-21

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 84.21  E-value: 4.57e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   6 LENIKSRRSVRAYTEQQ-VSAEDLNLILEAATHAPSGMNFQTWHFTAIQDaavlTELNEKIKGAFAKsddtrlQERGHSr 84
Cdd:cd02137     1 LEVIKSRRSVRNFDPDHkIPKEELKEILELATLAPSSFNLQPWRFVVVRD----PELKAKLAEAAYN------QPQVTT- 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2551177176  85 tyccyyhAPALIIVSneptcwwAPMDCACALQNIFLAAKSLGIGSCWInqlgqtcDDPDVRAFLTQLGIPENHRV 159
Cdd:cd02137    70 -------ASAVILVL-------GDLNAGLAAMNLMLAAKAKGYDTCPM-------GGFDKEKVAELLNLPDRYVP 123
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 6-161 4.19e-18

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 76.87  E-value: 4.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   6 LENIKSRRSVRAYTEQQ-VSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAV--LTELNEKIKGAFAKSDDTRLQERgh 82
Cdd:cd02135     1 LELIKTRRSIRKFKLTGaPPEEQLEELLEAAMWAPNHGKLEPWRFIVVTGEGRerLAELLAAAAAARAPGADPEKLEK-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  83 SRTYccYYHAPALIIV--SNEPTC-------WWApmdCACALQNIFLAAKSLGIGSCWInqLGQTCDDPDVRAFltqLGI 153
Cdd:cd02135    79 AREK--ALRAPVVIAVvaKPDEDPkvpeweqYAA---VGAAVQNLLLAAHALGLGAVWR--TGPVTYDPAVREA---LGL 148


                  ....*...
gi 2551177176 154 PENHRVYG 161
Cdd:cd02135   149 PEDERIVG 156
TdsD-like cd02138
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ...
 9-181 2.44e-17

nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380315 [Multi-domain]  Cd Length: 174  Bit Score: 75.27  E-value: 2.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   9 IKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHF-TAIQDaavlTELNEKIKGAFAKSDdtrlqerghsRTYC 87
Cdd:cd02138     2 IAERWSPRAFSPEPISEEDLLSLFEAARWAPSCFNEQPWRFvVARRD----TEAFEKLLDLLAEGN----------QSWA 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  88 cyYHAPALIIVS--NEPTC-----WWAPMDCACALQNIFLAAKSLGIGScwiNQLGQTcdDPD-VRAFltqLGIPENHRV 159
Cdd:cd02138    68 --KNAPVLIVVLakTEFDHngkpnRYALFDTGAAVANLALQATALGLVV---HQMAGF--DPEkAKEA---LGIPDEYEP 137

                         170       180
                  ....*....|....*....|..
gi 2551177176 160 YGCAALCYaPADAPVKDKKLAE 181
Cdd:cd02138   138 ITMIAIGY-PGDPESLPEKLLE 158
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
 5-61 1.50e-16

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 73.51  E-value: 1.50e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2551177176   5 VLENIKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLTEL 61
Cdd:cd03370     1 VKEAIESRRSIRKYTQEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVRDAELKEQL 57
NfsA-like cd02146
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ...
 5-176 9.80e-16

nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.


Pssm-ID: 380322 [Multi-domain]  Cd Length: 229  Bit Score: 72.27  E-value: 9.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   5 VLENIKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLTELNE--------KIKGAF--AKSDD 74
Cdd:cd02146     1 TIETILNHRSVRKFTDEPLTDETLETLIAAAQSASTSSNLQAYSVIVVTDPELREKLAElagnqpyvAQAPVFlvFCADL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  75 TRLQ----ERGHsrtYCCYYHAPALIIVsneptcwwAPMDCACALQNIFLAAKSLGIGSCWInqlGQTCDDPDvrAFLTQ 150
Cdd:cd02146    81 YRHQkiaeEAGG---KDVGLDYLESFLV--------GVVDAALAAQNALVAAESLGLGIVYI---GGIRNNPE--EVIEL 144

                         170       180
                  ....*....|....*....|....*...
gi 2551177176 151 LGIPENhrVYGCAALC--YAPADAPVKD 176
Cdd:cd02146   145 LGLPEY--VFPLFGLTvgHPDPTPEVKP 170
iodotyrosine_dehalogenase cd02144
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ...
 5-57 1.05e-12

iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.


Pssm-ID: 380320  Cd Length: 192  Bit Score: 63.33  E-value: 1.05e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2551177176   5 VLENIKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAV 57
Cdd:cd02144     1 FYELMKKRRSVRDFSSEPVPREVIENAIRTAGTAPSGANTQPWTFVVVSDPEI 53
NfsB-like cd02149
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ...
 4-132 6.12e-12

nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.


Pssm-ID: 380324 [Multi-domain]  Cd Length: 156  Bit Score: 60.73  E-value: 6.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   4 EVLENIKSRRSVRAYTEQQ-VSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLTELNEKIKGAFAKSDDtrlqergh 82
Cdd:cd02149     1 NILELLNFRYATKKFDPNKkISDEDLETILEALRLSPSSFGLEPWKFLVVENPELKAKLAPAAWFNQPQIKD-------- 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2551177176  83 srtyccyyhAPALIIVSNEPTcwWAPMDCACALQNIFLAAKSLGIGSCWI 132
Cdd:cd02149    73 ---------ASHVVVFLAKKD--WSAKQTYIALGNMLLAAAMLGIDSCPI 111
BluB cd02145
5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5, ...
 9-166 9.45e-11

5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5,6-dimethylbenzimidazole (DMB), a component of vitamin B12; is is a subfamily of the nitroreductase family; nitroreductases typically reduce their substrates by using NAD(P)H as electron donor and often use FMN as a cofactor.


Pssm-ID: 380321  Cd Length: 196  Bit Score: 58.14  E-value: 9.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   9 IKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLT---ELNEKIKGAFAKSDDTRLQERGHSRT 85
Cdd:cd02145     4 IRWRRDVRHFRPDPVPEEVLERLLQAAHLAPSVGLMQPWRFVRVRSAATRKavhELFQRANAEAAEMYTGERAAQYRTLK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  86 YCCYYHAPALIIVSNEPT---------CWWAPMD---CACALQNIFLAAKSLGIGSCWINQLgqtcdDPDvrAFLTQLGI 153
Cdd:cd02145    84 LEGIEEAPLQLAVFCDRAragghglgrTTMPEMDlysSVCAVQNLWLAARAEGLGVGWVSIL-----DPD--EVKRLLGI 156

                         170
                  ....*....|...
gi 2551177176 154 PENHRVygCAALC 166
Cdd:cd02145   157 PEHWEP--VAYLC 167
PRK10828 PRK10828
putative oxidoreductase; Provisional
 6-146 3.88e-07

putative oxidoreductase; Provisional


Pssm-ID: 182761  Cd Length: 183  Bit Score: 48.15  E-value: 3.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   6 LENIKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAV--LTELNEkiKGAFAKSDDTRLQERGHS 83
Cdd:PRK10828    4 LELLLNRRSASRLAEPAPTGEQLQNILRAGMRAPDHGSLQPWRFFVIEGEGRerFSALLE--QGAIAAGSDEKAIEKARN 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  84 RTyccyYHAPALIIV-------SNEPTcWWAPMDCACALQNIFLAAKSLGIGSCWinQLGQTCDDPDVRA 146
Cdd:PRK10828   82 AP----FRAPLIITVvakceenHKVPR-WEQEVSAGCAVMAMQMAAVAQGFNGIW--RSGAWTESPVVRE 144
PRK10765 PRK10765
oxygen-insensitive NADPH nitroreductase;
2-132 1.07e-05

oxygen-insensitive NADPH nitroreductase;


Pssm-ID: 182710  Cd Length: 240  Bit Score: 44.19  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   2 LNEVLENIKSRRSVRAYTEQQVSAEDLNLILEAATHAPSGMNFQTWHFTAIQDAAVLTELNEKIKG-AFAKSDDTRLqer 80
Cdd:PRK10765    1 MTPTIELILSHRSIRHFTDEPISEAQREAIINAARAASSSSFLQCSSIIRITDKALREALVELTGGqKYVAQAAEFW--- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2551177176  81 ghsrTYCCYYH-------------APALIIvsneptcwwAPMDCACALQNIFLAAKSLGIGSCWI 132
Cdd:PRK10765   78 ----VFCADFNrhlqicpdaqlglAEQLLI---------GAVDTAIMAQNALLAAESLGLGGVYI 129
TM1586_NiRdase pfam14512
Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase ...
 4-181 2.95e-05

Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase family, this family is a duplication, consisting of two similar domains arranged as the subunits of the dimeric NADH oxidase/flavin reductase with one conserved active site.


Pssm-ID: 405236 [Multi-domain]  Cd Length: 214  Bit Score: 43.05  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176   4 EVLENIKSRRSVRAYTEQQVSAEDLNLILEA--ATHAPSGMNFQtWHFtaiqdaAVLTELNEKIKGAFAKSddtrlqerg 81
Cdd:pfam14512   1 NLYEAIFKRHSVRKYTDEPIPEELLEELKNAidEINKLSGLNIQ-LVI------DDPDAFKGKAKYGKFKG--------- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176  82 hsrtyCCYYhapaLIIVSNEPTCwwAPMDCACALQNIFLAAKSLGIGSCWinqLGQTCDDPDVRAFltqlgIPENHRVYG 161
Cdd:pfam14512  65 -----VPNY----IAAYGEKDDD--LLENAGYYGEQIVLYATALGLGTCW---VGGTYSKSKVKAK-----IKKGEKLVI 125

                         170       180
                  ....*....|....*....|.
gi 2551177176 162 CAALCYAPAD-APVKDKKLAE 181
Cdd:pfam14512 126 VIAFGYGATKgVRAKRKPLDE 146
FbiB_C-like cd20607
nitroreductase family domain similar to the C-terminal domain of F420:gamma-glutamyl ligase ...
 114-182 1.39e-04

nitroreductase family domain similar to the C-terminal domain of F420:gamma-glutamyl ligase FbiB; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Mycobacterium tuberculosis FbiB, is a two-domain protein and produces F420 with predominantly 5 to 7 L-glutamate residues in the poly-gamma-glutamate tail, its C-terminal domain is homologous to FMN-dependent nitroreductases.


Pssm-ID: 380328 [Multi-domain]  Cd Length: 155  Bit Score: 40.53  E-value: 1.39e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551177176 114 ALQNIFLAAKSLGIGSCWInqlGQTCDDPD-VRAfltQLGIPENHRVYGCAALCYAPADAPVKDKKLAEG 182
Cdd:cd20607    92 AVQALLVALAVRGLGSCWI---GSTIFAPDvVRD---ELDLPDDWEPLGAIAIGYPLEPPPPRPPAPTDG 155
PRK11053 PRK11053
oxygen-insensitive NAD(P)H nitroreductase;
4-49 1.22e-03

oxygen-insensitive NAD(P)H nitroreductase;


Pssm-ID: 182929 [Multi-domain]  Cd Length: 217  Bit Score: 38.41  E-value: 1.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2551177176   4 EVLENIKSRRSVRAY-TEQQVSAEDLNLILEAATHAPSGMNFQTWHF 49
Cdd:PRK11053    2 DIVSVAKKRYTTKAFdPSKKLPAEQIEQIKTLLRFSPSSVNSQPWHF 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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