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Conserved domains on  [gi|2551748287|ref|WP_302596785|]
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methyl-accepting chemotaxis protein [uncultured Cellulosilyticum sp.]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 11435591)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
54-443 7.96e-65

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


:

Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 217.20  E-value: 7.96e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  54 DISILIGLHNLGNMLFNILAVSICLSIICTRFFKPFKSLIAACHRMEKGDFSTSIEeevLNTNDELGQVAIALAHMQDKL 133
Cdd:COG0840   175 AAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRID---VDSKDEIGQLADAFNRMIENL 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 134 NEFLAataheskrilsisdTLTQNATKTQEATTNIANAIQEIVSGAEEQTSFTEETAQMTTEIHTGMERVTTNIQEVTNA 213
Cdd:COG0840   252 RELVG--------------QVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAEL 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 214 ASLTLNSAHAGDNLIESVVAQMNDINDKVTSTAELVSLLGEKSNEIKNAVSLITDLAKQTNLLALNASIEAARAGDQGKG 293
Cdd:COG0840   318 AEEASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRG 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 294 FAVVADQVRVLAEQSASSATHITNITNEINSTIQNAIVSMSQGTSSVHEGLSLVQNAGTSFKEILTNIQQVSVEIEEVSA 373
Cdd:COG0840   398 FAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAA 477

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 374 ITEEVNAGTTSVLDAIENIATisssasnntqsvamSTDAQANLMNEVTKTAADLERRAKKLTVEVSKYTI 443
Cdd:COG0840   478 ASEEQSAGTEEVNQAIEQIAA--------------AAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
54-443 7.96e-65

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 217.20  E-value: 7.96e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  54 DISILIGLHNLGNMLFNILAVSICLSIICTRFFKPFKSLIAACHRMEKGDFSTSIEeevLNTNDELGQVAIALAHMQDKL 133
Cdd:COG0840   175 AAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRID---VDSKDEIGQLADAFNRMIENL 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 134 NEFLAataheskrilsisdTLTQNATKTQEATTNIANAIQEIVSGAEEQTSFTEETAQMTTEIHTGMERVTTNIQEVTNA 213
Cdd:COG0840   252 RELVG--------------QVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAEL 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 214 ASLTLNSAHAGDNLIESVVAQMNDINDKVTSTAELVSLLGEKSNEIKNAVSLITDLAKQTNLLALNASIEAARAGDQGKG 293
Cdd:COG0840   318 AEEASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRG 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 294 FAVVADQVRVLAEQSASSATHITNITNEINSTIQNAIVSMSQGTSSVHEGLSLVQNAGTSFKEILTNIQQVSVEIEEVSA 373
Cdd:COG0840   398 FAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAA 477

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 374 ITEEVNAGTTSVLDAIENIATisssasnntqsvamSTDAQANLMNEVTKTAADLERRAKKLTVEVSKYTI 443
Cdd:COG0840   478 ASEEQSAGTEEVNQAIEQIAA--------------AAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 167-420 1.07e-52

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 177.48  E-value: 1.07e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  167 NIANAIQEIVSGAEEQTSFTEETAQMTTEIHTGMERVTTNIQEVTNAASLTLNSAHAGDNLIESVVAQMNDINDKVTSTA 246
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  247 ELVSLLGEKSNEIKNAVSLITDLAKQTNLLALNASIEAARAGDQGKGFAVVADQVRVLAEQSASSATHITNITNEINSTI 326
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEET 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  327 QNAIVSMSQGTSSVHEGLSLVQNAGTSFKEILTNIQQVSVEIEEVSAITEEVNAGTTSVLDAIENIATISSSASNNTQSV 406
Cdd:smart00283 161 NEAVAAMEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250
                   ....*....|....
gi 2551748287  407 AMSTDAQANLMNEV 420
Cdd:smart00283 241 SAAAEELSGLAEEL 254
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 194-393 3.08e-47

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 161.25  E-value: 3.08e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 194 TEIHTGMERVTTNIQEVTNAASLTLNSAHAGDNLIESVVAQMNDINDKVTSTAELVSLLGEKSNEIKNAVSLITDLAKQT 273
Cdd:cd11386     1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 274 NLLALNASIEAARAGDQGKGFAVVADQVRVLAEQSASSATHITNITNEINSTIQNAIVSMSQGTSSVHEGLSLVQNAGTS 353
Cdd:cd11386    81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2551748287 354 FKEILTNIQQVSVEIEEVSAITEEVNAGTTSVLDAIENIA 393
Cdd:cd11386   161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 211-396 3.90e-34

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 125.62  E-value: 3.90e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 211 TNAASLTLNSAHAGDNLIESVVAQMNDINDKvtstaelvsllgekSNEIKNAVSLITDLAKQTNLLALNASIEAARAGDQ 290
Cdd:pfam00015   1 SDLAQLASEEAQDGGKEVANVVGQMEQIAQS--------------SKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQ 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 291 GKGFAVVADQVRVLAEQSASSATHITNITNEINSTIQNAIVSMSQGTSSVHEGLSLVQNAGTSFKEILTNIQQVSVEIEE 370
Cdd:pfam00015  67 GRGFAVVADEVRKLAERSAQAAKEIEALIIEIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQE 146

                         170       180
                  ....*....|....*....|....*.
gi 2551748287 371 VSAITEEVNAGTTSVLDAIENIATIS 396
Cdd:pfam00015 147 IAAASDEQSAGIDQVNQAVARMDQVT 172
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
47-444 1.88e-30

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 123.53  E-value: 1.88e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  47 DNVQKSHDISILIGLhnlgnmLFNILAVSICLSI-ICTRFFKPFKSLIAACHRMEKGDFSTSIEEEVLNtndELGQVAIA 125
Cdd:PRK15041  185 NNASYSQAMWILVGV------MIVVLAVIFAVWFgIKASLVAPMNRLIDSIRHIAGGDLVKPIEVDGSN---EMGQLAES 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 126 LAHMQDKLNEFLAATAHESKRILSisdtltqnatktqeATTNIANAIQEIVSGAEEQTSFTEETAQMTTEIHTGMERVTT 205
Cdd:PRK15041  256 LRHMQGELMRTVGDVRNGANAIYS--------------GASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNAE 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 206 NIQEVTNAASLTLNSAHAGDNLIESVVAQMNDIndkvtstaelvsllGEKSNEIKNAVSLITDLAKQTNLLALNASIEAA 285
Cdd:PRK15041  322 NARQASHLALSASETAQRGGKVVDNVVQTMRDI--------------STSSQKIADIISVIDGIAFQTNILALNAAVEAA 387

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 286 RAGDQGKGFAVVADQVRVLAEQSASSAthitnitNEINSTIQNAIvsmsqgtSSVHEGLSLVQNAGTSFKEILTNIQQVS 365
Cdd:PRK15041  388 RAGEQGRGFAVVAGEVRNLAQRSAQAA-------REIKSLIEDSV-------GKVDVGSTLVESAGETMAEIVSAVTRVT 453

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2551748287 366 VEIEEVSAITEEVNAGTTSVLDAIENIATIsssasnntqsvamsTDAQANLMNEVTKTAADLERRAKKLTVEVSKYTIK 444
Cdd:PRK15041  454 DIMGEIASASDEQSRGIDQVGLAVAEMDRV--------------TQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQ 518
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
54-443 7.96e-65

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 217.20  E-value: 7.96e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  54 DISILIGLHNLGNMLFNILAVSICLSIICTRFFKPFKSLIAACHRMEKGDFSTSIEeevLNTNDELGQVAIALAHMQDKL 133
Cdd:COG0840   175 AAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRID---VDSKDEIGQLADAFNRMIENL 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 134 NEFLAataheskrilsisdTLTQNATKTQEATTNIANAIQEIVSGAEEQTSFTEETAQMTTEIHTGMERVTTNIQEVTNA 213
Cdd:COG0840   252 RELVG--------------QVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAEL 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 214 ASLTLNSAHAGDNLIESVVAQMNDINDKVTSTAELVSLLGEKSNEIKNAVSLITDLAKQTNLLALNASIEAARAGDQGKG 293
Cdd:COG0840   318 AEEASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRG 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 294 FAVVADQVRVLAEQSASSATHITNITNEINSTIQNAIVSMSQGTSSVHEGLSLVQNAGTSFKEILTNIQQVSVEIEEVSA 373
Cdd:COG0840   398 FAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAA 477

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 374 ITEEVNAGTTSVLDAIENIATisssasnntqsvamSTDAQANLMNEVTKTAADLERRAKKLTVEVSKYTI 443
Cdd:COG0840   478 ASEEQSAGTEEVNQAIEQIAA--------------AAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 167-420 1.07e-52

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 177.48  E-value: 1.07e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  167 NIANAIQEIVSGAEEQTSFTEETAQMTTEIHTGMERVTTNIQEVTNAASLTLNSAHAGDNLIESVVAQMNDINDKVTSTA 246
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  247 ELVSLLGEKSNEIKNAVSLITDLAKQTNLLALNASIEAARAGDQGKGFAVVADQVRVLAEQSASSATHITNITNEINSTI 326
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEET 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  327 QNAIVSMSQGTSSVHEGLSLVQNAGTSFKEILTNIQQVSVEIEEVSAITEEVNAGTTSVLDAIENIATISSSASNNTQSV 406
Cdd:smart00283 161 NEAVAAMEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250
                   ....*....|....
gi 2551748287  407 AMSTDAQANLMNEV 420
Cdd:smart00283 241 SAAAEELSGLAEEL 254
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 194-393 3.08e-47

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 161.25  E-value: 3.08e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 194 TEIHTGMERVTTNIQEVTNAASLTLNSAHAGDNLIESVVAQMNDINDKVTSTAELVSLLGEKSNEIKNAVSLITDLAKQT 273
Cdd:cd11386     1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 274 NLLALNASIEAARAGDQGKGFAVVADQVRVLAEQSASSATHITNITNEINSTIQNAIVSMSQGTSSVHEGLSLVQNAGTS 353
Cdd:cd11386    81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2551748287 354 FKEILTNIQQVSVEIEEVSAITEEVNAGTTSVLDAIENIA 393
Cdd:cd11386   161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 211-396 3.90e-34

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 125.62  E-value: 3.90e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 211 TNAASLTLNSAHAGDNLIESVVAQMNDINDKvtstaelvsllgekSNEIKNAVSLITDLAKQTNLLALNASIEAARAGDQ 290
Cdd:pfam00015   1 SDLAQLASEEAQDGGKEVANVVGQMEQIAQS--------------SKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQ 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 291 GKGFAVVADQVRVLAEQSASSATHITNITNEINSTIQNAIVSMSQGTSSVHEGLSLVQNAGTSFKEILTNIQQVSVEIEE 370
Cdd:pfam00015  67 GRGFAVVADEVRKLAERSAQAAKEIEALIIEIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQE 146

                         170       180
                  ....*....|....*....|....*.
gi 2551748287 371 VSAITEEVNAGTTSVLDAIENIATIS 396
Cdd:pfam00015 147 IAAASDEQSAGIDQVNQAVARMDQVT 172
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
47-444 1.88e-30

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 123.53  E-value: 1.88e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  47 DNVQKSHDISILIGLhnlgnmLFNILAVSICLSI-ICTRFFKPFKSLIAACHRMEKGDFSTSIEEEVLNtndELGQVAIA 125
Cdd:PRK15041  185 NNASYSQAMWILVGV------MIVVLAVIFAVWFgIKASLVAPMNRLIDSIRHIAGGDLVKPIEVDGSN---EMGQLAES 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 126 LAHMQDKLNEFLAATAHESKRILSisdtltqnatktqeATTNIANAIQEIVSGAEEQTSFTEETAQMTTEIHTGMERVTT 205
Cdd:PRK15041  256 LRHMQGELMRTVGDVRNGANAIYS--------------GASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNAE 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 206 NIQEVTNAASLTLNSAHAGDNLIESVVAQMNDIndkvtstaelvsllGEKSNEIKNAVSLITDLAKQTNLLALNASIEAA 285
Cdd:PRK15041  322 NARQASHLALSASETAQRGGKVVDNVVQTMRDI--------------STSSQKIADIISVIDGIAFQTNILALNAAVEAA 387

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 286 RAGDQGKGFAVVADQVRVLAEQSASSAthitnitNEINSTIQNAIvsmsqgtSSVHEGLSLVQNAGTSFKEILTNIQQVS 365
Cdd:PRK15041  388 RAGEQGRGFAVVAGEVRNLAQRSAQAA-------REIKSLIEDSV-------GKVDVGSTLVESAGETMAEIVSAVTRVT 453

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2551748287 366 VEIEEVSAITEEVNAGTTSVLDAIENIATIsssasnntqsvamsTDAQANLMNEVTKTAADLERRAKKLTVEVSKYTIK 444
Cdd:PRK15041  454 DIMGEIASASDEQSRGIDQVGLAVAEMDRV--------------TQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQ 518
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 88-441 6.26e-29

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 118.96  E-value: 6.26e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  88 PFKSLIAACHRMEKGDFSTSIeeeVLNTNDELGQVAIALAHMQDKLNEFLAATAHESKRILSisdtltqnatktqeATTN 167
Cdd:PRK15048  219 PLAKIIAHIREIAGGNLANTL---TIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYA--------------GTRE 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 168 IANAIQEIVSGAEEQTSFTEETAQMTTEIHTGMERVTTNIQEVTNAASLTLNSAHAGDNLIESVVAQMNDINDKvtstae 247
Cdd:PRK15048  282 IAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADS------ 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 248 lvsllgekSNEIKNAVSLITDLAKQTNLLALNASIEAARAGDQGKGFAVVADQVRVLAEQSASSAthitnitNEINSTIQ 327
Cdd:PRK15048  356 --------SKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAA-------KEIKALIE 420

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 328 NAIvsmsqgtSSVHEGLSLVQNAGTSFKEILTNIQQVSVEIEEVSAITEEVNAGttsvldaIENIATISSSASNNTQSva 407
Cdd:PRK15048  421 DSV-------SRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRG-------IDQVALAVSEMDRVTQQ-- 484

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2551748287 408 mstdaQANLMNEVTKTAADLERRAKKLTVEVSKY 441
Cdd:PRK15048  485 -----NASLVQESAAAAAALEEQASRLTQAVSAF 513
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
149-425 7.79e-26

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 109.78  E-value: 7.79e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 149 SISDTLTQNATKTQEATTNIANAIQEIVSGAEEQTSFTEETAQMTTEIHTGMERVTTNIQEvtNAasltlNSAHAGDNLI 228
Cdd:PRK09793  254 TMQQALRGTVSDVRKGSQEMHIGIAEIVAGNNDLSSRTEQQAASLAQTAASMEQLTATVGQ--NA-----DNARQASELA 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 229 ESVVAQMNDINDKVTSTAELVSLLGEKSNEIKNAVSLITDLAKQTNLLALNASIEAARAGDQGKGFAVVADQVRVLAEQS 308
Cdd:PRK09793  327 KNAATTAQAGGVQVSTMTHTMQEIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRS 406

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 309 ASSATHITNITNEinstiqnaivsmsqGTSSVHEGLSLVQNAGTSFKEILTNIQQVSVEIEEVSAITEEVNAGTTSVLDA 388
Cdd:PRK09793  407 AQAAKEIKGLIEE--------------SVNRVQQGSKLVNNAAATMTDIVSSVTRVNDIMGEIASASEEQRRGIEQVAQA 472

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2551748287 389 IENIATISSSASNNTQSVAMSTDAQANLMNEVTKTAA 425
Cdd:PRK09793  473 VSQMDQVTQQNASLVEEAAVATEQLANQADHLSSRVA 509
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 87-133 3.27e-07

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 46.67  E-value: 3.27e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2551748287  87 KPFKSLIAACHRMEKGDFSTSIEEevlNTNDELGQVAIALAHMQDKL 133
Cdd:cd06225     2 RPLRRLTEAARRIAEGDLDVRVPV---RSKDEIGELARAFNQMAERL 45
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
87-138 9.34e-06

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 42.62  E-value: 9.34e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2551748287   87 KPFKSLIAACHRMEKGDFSTSIEEEvlnTNDELGQVAIALAHMQDKLNEFLA 138
Cdd:smart00304   5 RPLRRLAEAAQRIADGDLTVRLPVD---GRDEIGELARAFNEMADRLEETIA 53
HAMP pfam00672
HAMP domain;
84-135 2.25e-05

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 41.84  E-value: 2.25e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2551748287  84 RFFKPFKSLIAACHRMEKGDFSTSIEEevlNTNDELGQVAIALAHMQDKLNE 135
Cdd:pfam00672   5 RILRPLRRLAEAARRIASGDLDVRLPV---SGRDEIGELARAFNQMAERLRE 53
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 71-394 2.78e-04

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 42.95  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  71 ILAVSICLSIICTRFFKPFKSLIAACHRMEKGDFSTSIEeevLNTNDELGQVAIALAHMQDKLNEFLAATAHESKRILSI 150
Cdd:COG3850   128 LLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVP---VSGRDELGTLARAFNRMADELQELYAELEEEEELEAEL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 151 SDTLTQNATKTQEATTNIANAIQEIVSGAEEQTSFTEETAQMTTEIHTGMERVTTNIQEVTNAASLTLNSAHAGDNLIES 230
Cdd:COG3850   205 ELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELE 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 231 VVAQMNDINDKVTSTAELVSLLGEKSNEIKNAVSLITDLAKQTNLLALNASIEAARAGDQGKGFAVVADQVRVLAEQSAS 310
Cdd:COG3850   285 LLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAAGAALAA 364

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 311 SATHITNITNEINSTIQNAIVSMSQGTSSVHEGLSLVQNAGTSFKEILTNIQQVSVEIEEVSAITEEVNAGTTSVLDAIE 390
Cdd:COG3850   365 AAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGEGGLVVLIVSIIAGGEAIARGEALAARGLAAA 444


                  ....
gi 2551748287 391 NIAT 394
Cdd:COG3850   445 AALA 448
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 54-135 4.79e-04

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 42.26  E-value: 4.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  54 DISILIGLHNLGNMLFNILAVSICLSIICTRFFKPFKSLIAACHRMEKGDFSTSIEEevlNTNDELGQVAIALAHMQDKL 133
Cdd:COG5000     2 GLQILFLLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPV---TGDDEIGELARAFNRMTDQL 78


                  ..
gi 2551748287 134 NE 135
Cdd:COG5000    79 KE 80
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
71-150 1.86e-03

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 40.39  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  71 ILAVSICLSIICT----R-FFKPFKSLIAACHRMEKGDFSTSIEeevLNTNDELGQVAI---ALAHMQDKlNE-----FL 137
Cdd:PRK10549  169 IVALSTLLAALATfllaRgLLAPVKRLVEGTHKLAAGDFTTRVT---PTSRDELGRLAQdfnQLASTLEK-NEqmrrdFM 244

                          90
                  ....*....|...
gi 2551748287 138 AATAHESKRILSI 150
Cdd:PRK10549  245 ADISHELRTPLAV 257
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
68-428 8.93e-03

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 38.56  E-value: 8.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287  68 LFNILAVSICLSIICTRFFKPFKSLIAACHRMEKGDFSTSIEeevLNTNDELGQVAIALAHMQDKLNEflAATAHESKRI 147
Cdd:COG2770   219 LLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIP---VSRKDEIGELARAFNRMADSLRE--SIEEAEEEEE 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 148 LSISDTLTQNATKTQEATTNIANAIQEIVSGAEEQTSFTEETAQMTTEIHTGMERVTTNIQEVTNAASLTLNSAHAGDNL 227
Cdd:COG2770   294 LAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAEL 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 228 IESVVAQMNDINDKVTSTAELVSLLGEKSNEIKNAVSLITDLAKQTNLLALNASIEAARAGDQGKGFAVVADQVRVLAEQ 307
Cdd:COG2770   374 LVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEA 453

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2551748287 308 SASSATHITNITNEINSTIQNAIVSMSQGTSSVHEGLSLVQNAGTSFKEILTNIQQVSVEIEEVSAITEEVNAGTTSVLD 387
Cdd:COG2770   454 EGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEGLLLLLLLEAEALEVAEELL 533

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2551748287 388 AIENIATISSSASNNTQSVAMSTDAQANLMNEVTKTAADLE 428
Cdd:COG2770   534 ELEEAALLLAAAAELAALLALLLALAAVEAAALLLAALLLA 574
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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