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Conserved domains on  [gi|2556145847|ref|WP_303925954|]
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shikimate kinase [Draconibacterium sediminis]

Protein Classification

nucleoside/nucleotide kinase family protein( domain architecture ID 106737)

nucleoside/nucleotide kinase family protein may catalyze the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 2-148 1.15e-68

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member PRK13949:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 169  Bit Score: 205.73  E-value: 1.15e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   2 RVYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGAP 81
Cdd:PRK13949    3 RIFLVGYMGAGKTTLGKALARELGLSFIDLDFFIENRFHKTVGDIFAERGEAVFRELERNMLHEVAEFEDVVISTGGGAP 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2556145847  82 CFFDNIDLMNKTGKTVFLNIDPAILADRLLKSKTERPLIKGKSREELVAFIDETLKKRKQFYSQAQY 148
Cdd:PRK13949   83 CFFDNMELMNASGTTVYLKVSPEVLFVRLRLAKQQRPLLKGKSDEELLDFIIEALEKRAPFYRQAKI 149
 
Name Accession Description Interval E-value
PRK13949 PRK13949
shikimate kinase; Provisional
 2-148 1.15e-68

shikimate kinase; Provisional


Pssm-ID: 140006 [Multi-domain]  Cd Length: 169  Bit Score: 205.73  E-value: 1.15e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   2 RVYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGAP 81
Cdd:PRK13949    3 RIFLVGYMGAGKTTLGKALARELGLSFIDLDFFIENRFHKTVGDIFAERGEAVFRELERNMLHEVAEFEDVVISTGGGAP 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2556145847  82 CFFDNIDLMNKTGKTVFLNIDPAILADRLLKSKTERPLIKGKSREELVAFIDETLKKRKQFYSQAQY 148
Cdd:PRK13949   83 CFFDNMELMNASGTTVYLKVSPEVLFVRLRLAKQQRPLLKGKSDEELLDFIIEALEKRAPFYRQAKI 149
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 3-164 1.96e-61

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 186.87  E-value: 1.96e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   3 VYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGAPC 82
Cdd:COG0703     1 IVLIGMMGAGKSTVGRLLAKRLGLPFVDTDAEIEERAGMSIPEIFAEEGEAGFRELEREVLAELLEEENAVIATGGGAVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847  83 FFDNIDLMNKTGKTVFLNIDPAILADRlLKSKTERPLIKGksrEELVAFIDETLKKRKQFYSQ-AQYEITEPDFSLDQLQ 161
Cdd:COG0703    81 SPENRELLKEHGTVVYLDASPETLLER-LRRDDNRPLLQG---EDPRERLEELLAEREPLYREvADITVDTDGRSPEEVV 156


                  ...
gi 2556145847 162 EMI 164
Cdd:COG0703   157 DEI 159
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 2-159 2.05e-53

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 166.19  E-value: 2.05e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   2 RVYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGAP 81
Cdd:cd00464     1 NIVLIGMMGAGKTTVGRLLAKALGLPFVDLDELIEQRAGMSIPEIFAEEGEEGFRELEREVLLLLLTKENAVIATGGGAV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2556145847  82 CFFDNIDLMNKTGKTVFLNIDPAILADRLLKSKTeRPLIKGKSREELvafiDETLKKRKQFYSQ-AQYEITEPDFSLDQ 159
Cdd:cd00464    81 LREENRRLLLENGIVVWLDASPEELLERLARDKT-RPLLQDEDPERL----RELLEEREPLYREvADLTIDTDELSPEE 154
SKI pfam01202
Shikimate kinase;
9-146 6.61e-48

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 152.35  E-value: 6.61e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   9 MGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGAPCFFDNID 88
Cdd:pfam01202   1 MGAGKSTIGRLLAKALGLPFIDTDEEIEKRTGMSIAEIFEEEGEEGFRRLESEVLKELLAEHGLVIATGGGAVLSEENRD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2556145847  89 LMNKTGKTVFLNIDPAILADRlLKSKTERPLIKGKSREELVafIDETLKKRKQFYSQA 146
Cdd:pfam01202  81 LLKERGIVIYLDAPLEVLLER-LKRDKTRPLLQNKDPEEEL--LELLFEERDPLYEEA 135
 
Name Accession Description Interval E-value
PRK13949 PRK13949
shikimate kinase; Provisional
 2-148 1.15e-68

shikimate kinase; Provisional


Pssm-ID: 140006 [Multi-domain]  Cd Length: 169  Bit Score: 205.73  E-value: 1.15e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   2 RVYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGAP 81
Cdd:PRK13949    3 RIFLVGYMGAGKTTLGKALARELGLSFIDLDFFIENRFHKTVGDIFAERGEAVFRELERNMLHEVAEFEDVVISTGGGAP 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2556145847  82 CFFDNIDLMNKTGKTVFLNIDPAILADRLLKSKTERPLIKGKSREELVAFIDETLKKRKQFYSQAQY 148
Cdd:PRK13949   83 CFFDNMELMNASGTTVYLKVSPEVLFVRLRLAKQQRPLLKGKSDEELLDFIIEALEKRAPFYRQAKI 149
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 3-164 1.96e-61

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 186.87  E-value: 1.96e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   3 VYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGAPC 82
Cdd:COG0703     1 IVLIGMMGAGKSTVGRLLAKRLGLPFVDTDAEIEERAGMSIPEIFAEEGEAGFRELEREVLAELLEEENAVIATGGGAVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847  83 FFDNIDLMNKTGKTVFLNIDPAILADRlLKSKTERPLIKGksrEELVAFIDETLKKRKQFYSQ-AQYEITEPDFSLDQLQ 161
Cdd:COG0703    81 SPENRELLKEHGTVVYLDASPETLLER-LRRDDNRPLLQG---EDPRERLEELLAEREPLYREvADITVDTDGRSPEEVV 156


                  ...
gi 2556145847 162 EMI 164
Cdd:COG0703   157 DEI 159
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 2-159 2.05e-53

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 166.19  E-value: 2.05e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   2 RVYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGAP 81
Cdd:cd00464     1 NIVLIGMMGAGKTTVGRLLAKALGLPFVDLDELIEQRAGMSIPEIFAEEGEEGFRELEREVLLLLLTKENAVIATGGGAV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2556145847  82 CFFDNIDLMNKTGKTVFLNIDPAILADRLLKSKTeRPLIKGKSREELvafiDETLKKRKQFYSQ-AQYEITEPDFSLDQ 159
Cdd:cd00464    81 LREENRRLLLENGIVVWLDASPEELLERLARDKT-RPLLQDEDPERL----RELLEEREPLYREvADLTIDTDELSPEE 154
SKI pfam01202
Shikimate kinase;
9-146 6.61e-48

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 152.35  E-value: 6.61e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   9 MGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGAPCFFDNID 88
Cdd:pfam01202   1 MGAGKSTIGRLLAKALGLPFIDTDEEIEKRTGMSIAEIFEEEGEEGFRRLESEVLKELLAEHGLVIATGGGAVLSEENRD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2556145847  89 LMNKTGKTVFLNIDPAILADRlLKSKTERPLIKGKSREELVafIDETLKKRKQFYSQA 146
Cdd:pfam01202  81 LLKERGIVIYLDAPLEVLLER-LKRDKTRPLLQNKDPEEEL--LELLFEERDPLYEEA 135
aroK PRK00131
shikimate kinase; Reviewed
 1-145 8.04e-47

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 150.34  E-value: 8.04e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   1 MRVYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGA 80
Cdd:PRK00131    5 PNIVLIGFMGAGKSTIGRLLAKRLGYDFIDTDHLIEARAGKSIPEIFEEEGEAAFRELEEEVLAELLARHNLVISTGGGA 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2556145847  81 PCFFDNIDLMNKTGKTVFLNIDPAILADRlLKSKTERPLIK-GKSREELVAFidetLKKRKQFYSQ 145
Cdd:PRK00131   85 VLREENRALLRERGTVVYLDASFEELLRR-LRRDRNRPLLQtNDPKEKLRDL----YEERDPLYEE 145
PRK13947 PRK13947
shikimate kinase; Provisional
 3-164 6.58e-31

shikimate kinase; Provisional


Pssm-ID: 184412 [Multi-domain]  Cd Length: 171  Bit Score: 109.80  E-value: 6.58e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   3 VYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGAPC 82
Cdd:PRK13947    4 IVLIGFMGTGKTTVGKRVATTLSFGFIDTDKEIEKMTGMTVAEIFEKDGEVRFRSEEKLLVKKLARLKNLVIATGGGVVL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847  83 FFDNIDLMNKTGKTVFLNIDPAILADRlLKSKTERPLIkgkSREELVAFIDETLKKRKQFYSQAQYEITEPDFSLDQLQE 162
Cdd:PRK13947   84 NPENVVQLRKNGVVICLKARPEVILRR-VGKKKSRPLL---MVGDPEERIKELLKEREPFYDFADYTIDTGDMTIDEVAE 159


                  ..
gi 2556145847 163 MI 164
Cdd:PRK13947  160 EI 161
PRK13951 PRK13951
bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;
1-145 4.76e-29

bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;


Pssm-ID: 172457 [Multi-domain]  Cd Length: 488  Bit Score: 110.76  E-value: 4.76e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   1 MRVYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGA 80
Cdd:PRK13951    1 MRIFLVGMMGSGKSTIGKRVSEVLDLQFIDMDEEIERREGRSVRRIFEEDGEEYFRLKEKELLRELVERDNVVVATGGGV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2556145847  81 PCFFDNIDLMNKTgKTVFLNIDPAILADRLlkSKTERPLIK-GKSReelvafIDETLKKRKQFYSQ 145
Cdd:PRK13951   81 VIDPENRELLKKE-KTLFLYAPPEVLMERV--TTENRPLLReGKER------IREIWERRKQFYTE 137
PRK13946 PRK13946
shikimate kinase; Provisional
 3-159 9.80e-29

shikimate kinase; Provisional


Pssm-ID: 184411 [Multi-domain]  Cd Length: 184  Bit Score: 104.24  E-value: 9.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   3 VYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGAPC 82
Cdd:PRK13946   13 VVLVGLMGAGKSTVGRRLATMLGLPFLDADTEIERAARMTIAEIFAAYGEPEFRDLERRVIARLLKGGPLVLATGGGAFM 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2556145847  83 FFDNIDLMNKTGKTVFLNIDPAILADRlLKSKTERPLIKGKS-REELVAFIDEtlkkRKQFYSQAQYEITEPDFSLDQ 159
Cdd:PRK13946   93 NEETRAAIAEKGISVWLKADLDVLWER-VSRRDTRPLLRTADpKETLARLMEE----RYPVYAEADLTVASRDVPKEV 165
aroL PRK03731
shikimate kinase AroL;
2-146 1.24e-25

shikimate kinase AroL;


Pssm-ID: 235153 [Multi-domain]  Cd Length: 171  Bit Score: 96.16  E-value: 1.24e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   2 RVYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEfTDVIIATGGGAP 81
Cdd:PRK03731    4 PLFLVGARGCGKTTVGMALAQALGYRFVDTDQWLQSTSNMTVAEIVEREGWAGFRARESAALEAVTA-PSTVIATGGGII 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2556145847  82 CFFDNIDLMNKTGKTVFLNIDPAILADRLLKS--KTERPLIKGKSreeLVAFIDETLKKRKQFYSQA 146
Cdd:PRK03731   83 LTEENRHFMRNNGIVIYLCAPVSVLANRLEANpeEDQRPTLTGKP---ISEEVAEVLAEREALYREV 146
PRK13948 PRK13948
shikimate kinase; Provisional
 3-146 4.29e-23

shikimate kinase; Provisional


Pssm-ID: 184413 [Multi-domain]  Cd Length: 182  Bit Score: 89.85  E-value: 4.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   3 VYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGAPC 82
Cdd:PRK13948   13 VALAGFMGTGKSRIGWELSRALMLHFIDTDRYIERVTGKSIPEIFRHLGEAYFRRCEAEVVRRLTRLDYAVISLGGGTFM 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2556145847  83 FFDNIDLMNKTGKTVFLNIDPAILADRLLKSKteRPLIKGksrEELVAFIDETLKKRKQFYSQA 146
Cdd:PRK13948   93 HEENRRKLLSRGPVVVLWASPETIYERTRPGD--RPLLQV---EDPLGRIRTLLNEREPVYRQA 151
aroK PRK05057
shikimate kinase AroK;
3-143 1.06e-22

shikimate kinase AroK;


Pssm-ID: 235335 [Multi-domain]  Cd Length: 172  Bit Score: 88.62  E-value: 1.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   3 VYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGAPC 82
Cdd:PRK05057    7 IFLVGPMGAGKSTIGRQLAQQLNMEFYDSDQEIEKRTGADIGWVFDVEGEEGFRDREEKVINELTEKQGIVLATGGGSVK 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2556145847  83 FFDNIDLMNKTGKTVFLNidpAILADRLLKSK--TERPLIKGK-SREELVAFIDEtlkkRKQFY 143
Cdd:PRK05057   87 SRETRNRLSARGVVVYLE---TTIEKQLARTQrdKKRPLLQVDdPREVLEALANE----RNPLY 143
PLN02199 PLN02199
shikimate kinase
 3-157 3.31e-21

shikimate kinase


Pssm-ID: 177850 [Multi-domain]  Cd Length: 303  Bit Score: 87.45  E-value: 3.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   3 VYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEE-RNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGAP 81
Cdd:PLN02199  105 MYLVGMMGSGKTTVGKLMSKVLGYTFFDCDTLIEQaMNGTSVAEIFVHHGENFFRGKETDALKKLSSRYQVVVSTGGGAV 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847  82 CFFDNIDLMNKtGKTVFLNIDPAILADRLLKSKT-ERPLIKGKSREEL-VAF--IDETLKKRKQFYSQAQYEITEPDFSL 157
Cdd:PLN02199  185 IRPINWKYMHK-GISIWLDVPLEALAHRIAAVGTdSRPLLHDESGDAYsVAFkrLSAIWDERGEAYTNANARVSLENIAA 263
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 2-165 1.07e-20

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 86.16  E-value: 1.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   2 RVYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEE-LAEFTDVIIATGGG- 79
Cdd:PRK08154  135 RIALIGLRGAGKSTLGRMLAARLGVPFVELNREIEREAGLSVSEIFALYGQEGYRRLERRALERlIAEHEEMVLATGGGi 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847  80 --APCFFdniDLMNKTGKTVFLNIDPAILADRLLKSKTERPLIKGKS-REELVAFidetLKKRKQFYSQAQYEI----TE 152
Cdd:PRK08154  215 vsEPATF---DLLLSHCYTVWLKASPEEHMARVRAQGDLRPMADNREaMEDLRRI----LASREPLYARADAVVdtsgLT 287

                         170
                  ....*....|...
gi 2556145847 153 PDFSLDQLQEMIS 165
Cdd:PRK08154  288 VAQSLARLRELVR 300
PRK14021 PRK14021
bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional
 5-126 1.21e-18

bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional


Pssm-ID: 184458 [Multi-domain]  Cd Length: 542  Bit Score: 81.83  E-value: 1.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   5 LIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTVPQIFADHGEDGFRERERKALEELAEFTDVIIATGGGAPCFF 84
Cdd:PRK14021   11 IIGMMGAGKTRVGKEVAQMMRLPFADADVEIEREIGMSIPSYFEEYGEPAFREVEADVVADMLEDFDGIFSLGGGAPMTP 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2556145847  85 DN----IDLMNKTGKTVFLNIDPAILADRLLKSKTeRPLIKGKSRE 126
Cdd:PRK14021   91 STqhalASYIAHGGRVVYLDADPKEAMERANRGGG-RPMLNGDANK 135
PRK00625 PRK00625
shikimate kinase; Provisional
 1-127 9.16e-12

shikimate kinase; Provisional


Pssm-ID: 134335 [Multi-domain]  Cd Length: 173  Bit Score: 59.77  E-value: 9.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   1 MRVYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEER----NCKTVPQIFADHGEDGFRERERKALEELAeFTDVIIAT 76
Cdd:PRK00625    1 MQIFLCGLPTVGKTSFGKALAKFLSLPFFDTDDLIVSNyhgaLYSSPKEIYQAYGEEGFCREEFLALTSLP-VIPSIVAL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2556145847  77 GGGAPCFFDNIDLMNKTGKTVFLNIDPAILADRLLKSKTERPLIKGKSREE 127
Cdd:PRK00625   80 GGGTLMIEPSYAHIRNRGLLVLLSLPIATIYQRLQKRGLPERLKHAPSLEE 130
AAA_18 pfam13238
AAA domain;
5-130 7.73e-08

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 48.58  E-value: 7.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   5 LIGYMGCGKSRTGRLLSEHMGVPFIDMdDYIEERNCKTV--PQIFADHGED-GFRERERKALEELAEFT--DVIIATGGG 79
Cdd:pfam13238   3 ITGTPGVGKTTLAKELSKRLGFGDNVR-DLALENGLVLGddPETRESKRLDeDKLDRLLDLLEENAALEegGNLIIDGHL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2556145847  80 APCFFDnidlMNKTGKTVFLNIDPAILADRLLKSKTERPLIKGKSREELVA 130
Cdd:pfam13238  82 AELEPE----RAKDLVGIVLRASPEELLERLEKRGYEEAKIKENEEAEILG 128
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
9-157 8.24e-08

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 49.44  E-value: 8.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   9 MGCGKSRTGRLLSEHMGVPFID------------MDDYIEERNCKTVPQIFADHG--EDGFRERERKALEELAEFTDVII 74
Cdd:COG1102     9 PGSGGTTIAKRLAEKLGLPLYDgeilreaakergLSEEEFEKLDEKAPSLLYRDTaeEDEIDRALDKVIRELARKGNCVI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847  75 aTGGGAPCFF-DNIDLMNktgktVFLNIDPAILADRLLKSkterpliKGKSREELVAFIDETLKKRKQFYsQAQYEITEP 153
Cdd:COG1102    89 -VGRLADWILrDRPNVLK-----VFLTAPLEVRVKRIAER-------EGISEEEAEKEIKKRDKSRAKYY-KYYYGIDWG 154


                  ....
gi 2556145847 154 DFSL 157
Cdd:COG1102   155 DPSN 158
GntK COG3265
Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the ...
 1-34 1.71e-06

Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442496 [Multi-domain]  Cd Length: 164  Bit Score: 45.50  E-value: 1.71e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2556145847   1 MRVYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDY 34
Cdd:COG3265     2 MVIVVMGVSGSGKSTVGQALAERLGWPFIDGDDF 35
PRK06217 PRK06217
hypothetical protein; Validated
 1-127 3.52e-06

hypothetical protein; Validated


Pssm-ID: 168472  Cd Length: 183  Bit Score: 44.66  E-value: 3.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   1 MRVYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEErncKTVPQIFADHGEDgfrERERKALEELAEFTDVIIAtggGA 80
Cdd:PRK06217    2 MRIHITGASGSGTTTLGAALAERLDIPHLDTDDYFWL---PTDPPFTTKRPPE---ERLRLLLEDLRPREGWVLS---GS 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2556145847  81 PC-----FFDNIDLMnktgktVFLNIDPAILADRLLKSKTER---PLIKGKSREE 127
Cdd:PRK06217   73 ALgwgdpLEPLFDLV------VFLTIPPELRLERLRLREFQRygnRILPGGDMHK 121
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 10-34 2.18e-04

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 39.54  E-value: 2.18e-04
                          10        20
                  ....*....|....*....|....*
gi 2556145847  10 GCGKSRTGRLLSEHMGVPFIDMDDY 34
Cdd:cd02021     9 GSGKSTVGKALAERLGAPFIDGDDL 33
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
1-130 4.93e-04

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 38.64  E-value: 4.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   1 MRVYLIGYMGCGKSRTGRLLSEHMGVPFIDMDDYIEERNCKTvpqifadhGEDGFR-------ERERKALEELAEfTDVI 73
Cdd:COG1936     1 MRIAITGTPGTGKTTVAKLLAERLGLEVIHLNDLVKEEGLYT--------EVDEERdslvvdeDALAEELEELKE-GDVI 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2556145847  74 IAtgGGAPCFFDnIDLMnktgktVFLNIDPAILADRLLksktERPLIKGKSREELVA 130
Cdd:COG1936    72 IE--GHLAHLVD-VDRV------IVLRCNPEVLEERLE----ERGYSEEKIRENVEA 115
Cytidylate_kin2 pfam13189
Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.
 9-143 8.23e-04

Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.


Pssm-ID: 433023 [Multi-domain]  Cd Length: 176  Bit Score: 37.99  E-value: 8.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   9 MGCGKSRTGRLLSEHMGVPFID---MDDYIEERNC--------------------KTVPQIFADHG-EDGFRERERKALE 64
Cdd:pfam13189   8 YGSGGTTIAKKLAEKLGYPFYDreiLDEIAKELGIseeefelfdeksrlssflysLAGGRVRGDALsDDRLFDAQSKVIR 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2556145847  65 ELAEFTDVIIaTGGGAPCFFDNIDLMNKtgktVFLNIDPAILADRLLKSkterpliKGKSREELVAFIDETLKKRKQFY 143
Cdd:pfam13189  88 ELAAEDNCVI-VGRGADYILKDIPNVLR----VFLTAPLEDRVKRVMER-------EGLSEEEARELIKETDKRRAKYY 154
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
5-112 1.01e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 37.59  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   5 LIGYMGCGKSRTGRLLSEHMGVPFIDMDDyIEERNCKTVPQIFADHGEdgFRERERKALEELAEF-----TDVII----- 74
Cdd:COG0645     4 VCGLPGSGKSTLARALAERLGAVRLRSDV-VRKRLFGAGLAPLERSPE--ATARTYARLLALAREllaagRSVILdatfl 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2556145847  75 -----------ATGGGAPCFFdnidlmnktgktVFLNIDPAILADRLLK 112
Cdd:COG0645    81 rraqreafralAEEAGAPFVL------------IWLDAPEEVLRERLEA 117
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 3-94 9.92e-03

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 34.49  E-value: 9.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556145847   3 VYLIGYMGCGKSRTGRLLSEHMGVPFIDMddyieerNCKTVPQIFADHGEDGFRERERKALEElaeftdviiatgggAPC 82
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEI-------SGSELVSKYVGESEKRLRELFEAAKKL--------------APC 59

                          90
                  ....*....|....
gi 2556145847  83 --FFDNIDLMNKTG 94
Cdd:pfam00004  60 viFIDEIDALAGSR 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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