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Conserved domains on  [gi|2559584876|ref|WP_304908970|]
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class I SAM-dependent methyltransferase [Methylotenera sp.]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10606006)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor similar to histamine N-methyltransferase

CATH:  2.20.25.110
EC:  2.1.-.-|2.1.1.-
Gene Ontology:  GO:0032259|GO:0008757|GO:1904047|GO:0008168
PubMed:  12826405|12504684

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 108-248 4.06e-21

Methyltransferase domain; This family appears to be a methyltransferase domain.


:

Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 87.87  E-value: 4.06e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 108 ESGKILDVGCYAGQFLAAFSPS-YDKFGVEPSQAAAVRAGDKGIHVLGATINDIAPEMKFDCIVSIDVVEHLLDPVDFFN 186
Cdd:pfam13489  22 SPGRVLDFGCGTGIFLRLLRAQgFSVTGVDPSPIAIERALLNVRFDQFDEQEAAVPAGKFDVIVAREVLEHVPDPPALLR 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2559584876 187 KAFQLLNPNGFLIISTGNpSSFAWRHIFKSRFWYVTNAEHVSFPSQKFIKNLTHKLGGEVVE 248
Cdd:pfam13489 102 QIAALLKPGGLLLLSTPL-ASDEADRLLLEWPYLRPRNGHISLFSARSLKRLLEEAGFEVVS 162
 
Name Accession Description Interval E-value
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 108-248 4.06e-21

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 87.87  E-value: 4.06e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 108 ESGKILDVGCYAGQFLAAFSPS-YDKFGVEPSQAAAVRAGDKGIHVLGATINDIAPEMKFDCIVSIDVVEHLLDPVDFFN 186
Cdd:pfam13489  22 SPGRVLDFGCGTGIFLRLLRAQgFSVTGVDPSPIAIERALLNVRFDQFDEQEAAVPAGKFDVIVAREVLEHVPDPPALLR 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2559584876 187 KAFQLLNPNGFLIISTGNpSSFAWRHIFKSRFWYVTNAEHVSFPSQKFIKNLTHKLGGEVVE 248
Cdd:pfam13489 102 QIAALLKPGGLLLLSTPL-ASDEADRLLLEWPYLRPRNGHISLFSARSLKRLLEEAGFEVVS 162
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 105-204 4.69e-21

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 86.61  E-value: 4.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 105 HVLESGKILDVGCYAGQFLAAFSPS-YDKFGVEPS----QAAAVRAGDKGIHVLGATINDIA-PEMKFDCIVSIDVVEHL 178
Cdd:COG2227    21 LLPAGGRVLDVGCGTGRLALALARRgADVTGVDISpealEIARERAAELNVDFVQGDLEDLPlEDGSFDLVICSEVLEHL 100

                          90       100
                  ....*....|....*....|....*.
gi 2559584876 179 LDPVDFFNKAFQLLNPNGFLIISTGN 204
Cdd:COG2227   101 PDPAALLRELARLLKPGGLLLLSTPN 126
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 111-201 2.42e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 51.28  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 111 KILDVGCYAGQFLAAFSPSYDK--FGVEPS-------QAAAVRAGDKGIHVLGATINDIAPEM--KFDCIVSIDVVEHLL 179
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGArvTGVDISpvalelaRKAAAALLADNVEVLKGDAEELPPEAdeSFDVIISDPPLHHLV 80

                          90       100
                  ....*....|....*....|...
gi 2559584876 180 -DPVDFFNKAFQLLNPNGFLIIS 201
Cdd:cd02440    81 eDLARFLEEARRLLKPGGVLVLT 103
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
107-202 7.76e-06

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 46.77  E-value: 7.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 107 LESGKILDVGCYAGQFL---AAFSPsydKF--GVEPS-----QAAAVR---AGDKGIHVLGATINDIAPEMKFDCIVSID 173
Cdd:PRK15068  121 LKGRTVLDVGCGNGYHMwrmLGAGA---KLvvGIDPSqlflcQFEAVRkllGNDQRAHLLPLGIEQLPALKAFDTVFSMG 197

                          90       100
                  ....*....|....*....|....*....
gi 2559584876 174 VVEHLLDPVDFFNKAFQLLNPNGFLIIST 202
Cdd:PRK15068  198 VLYHRRSPLDHLKQLKDQLVPGGELVLET 226
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 105-217 6.43e-03

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 37.27  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 105 HVLESGKILDVGCYAGQFLAAFSPSYDKfgvepsqaaavragdkgIHVLGatiNDIAPEM-------------------- 164
Cdd:TIGR02072  31 GIFIPASVLDIGCGTGYLTRALLKRFPQ-----------------AEFIA---LDISAGMlaqaktklsenvqficgdae 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2559584876 165 -------KFDCIVSIDVVEHLLDPVDFFNKAFQLLNPNGFLIISTGNPSSFA-WRHIFKSR 217
Cdd:TIGR02072  91 klpledsSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHeLRQSFGQH 151
 
Name Accession Description Interval E-value
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 108-248 4.06e-21

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 87.87  E-value: 4.06e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 108 ESGKILDVGCYAGQFLAAFSPS-YDKFGVEPSQAAAVRAGDKGIHVLGATINDIAPEMKFDCIVSIDVVEHLLDPVDFFN 186
Cdd:pfam13489  22 SPGRVLDFGCGTGIFLRLLRAQgFSVTGVDPSPIAIERALLNVRFDQFDEQEAAVPAGKFDVIVAREVLEHVPDPPALLR 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2559584876 187 KAFQLLNPNGFLIISTGNpSSFAWRHIFKSRFWYVTNAEHVSFPSQKFIKNLTHKLGGEVVE 248
Cdd:pfam13489 102 QIAALLKPGGLLLLSTPL-ASDEADRLLLEWPYLRPRNGHISLFSARSLKRLLEEAGFEVVS 162
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 105-204 4.69e-21

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 86.61  E-value: 4.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 105 HVLESGKILDVGCYAGQFLAAFSPS-YDKFGVEPS----QAAAVRAGDKGIHVLGATINDIA-PEMKFDCIVSIDVVEHL 178
Cdd:COG2227    21 LLPAGGRVLDVGCGTGRLALALARRgADVTGVDISpealEIARERAAELNVDFVQGDLEDLPlEDGSFDLVICSEVLEHL 100

                          90       100
                  ....*....|....*....|....*.
gi 2559584876 179 LDPVDFFNKAFQLLNPNGFLIISTGN 204
Cdd:COG2227   101 PDPAALLRELARLLKPGGLLLLSTPN 126
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
74-202 8.25e-16

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 73.88  E-value: 8.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876  74 DYLALYESvnsDIWEDDALRKDQILVHSAISHVL--ESGKILDVGC---YAGQFLAAFSPSYDkfGVEPSQAAAVRAGDK 148
Cdd:COG4976    13 QYADSYDA---ALVEDLGYEAPALLAEELLARLPpgPFGRVLDLGCgtgLLGEALRPRGYRLT--GVDLSEEMLAKAREK 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2559584876 149 GIHV--LGATINDIA-PEMKFDCIVSIDVVEHLLDPVDFFNKAFQLLNPNGFLIIST 202
Cdd:COG4976    88 GVYDrlLVADLADLAePDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSV 144
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
108-202 4.49e-14

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 66.77  E-value: 4.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 108 ESGKILDVGCYAGQFLAAFSPSYDKF---GVEPSQAAAVRAGDK--GIHVLGATINDIAPEMKFDCIVSIDVVEHLLDPV 182
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPGArvtGVDLSPEMLARARARlpNVRFVVADLRDLDPPEPFDLVVSNAALHWLPDHA 80

                          90       100
                  ....*....|....*....|
gi 2559584876 183 DFFNKAFQLLNPNGFLIIST 202
Cdd:COG4106    81 ALLARLAAALAPGGVLAVQV 100
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 113-200 2.55e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 59.22  E-value: 2.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 113 LDVGCYAGQFLAAFSPSYDK-FGVEPS----QAAAVRAGDKGIHVLGATINDIA-PEMKFDCIVSIDVVEHLLDPVDFFN 186
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARvTGVDISpemlELAREKAPREGLTFVVGDAEDLPfPDNSFDLVLSSEVLHHVEDPERALR 80

                          90
                  ....*....|....
gi 2559584876 187 KAFQLLNPNGFLII 200
Cdd:pfam08241  81 EIARVLKPGGILII 94
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 110-216 7.23e-11

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 59.24  E-value: 7.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 110 GKILDVGCYAGQFLAAFSPSYDKF-GVEPSQA----AAVRAGDKG--IHVLGATINDIA-PEMKFDCIVSIDVVEHLLDP 181
Cdd:COG2226    24 ARVLDLGCGTGRLALALAERGARVtGVDISPEmlelARERAAEAGlnVEFVVGDAEDLPfPDGSFDLVISSFVLHHLPDP 103

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2559584876 182 VDFFNKAFQLLNPNGFLIISTGN-PSSFAWRHIFKS 216
Cdd:COG2226   104 ERALAEIARVLKPGGRLVVVDFSpPDLAELEELLAE 139
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 108-201 2.11e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 59.16  E-value: 2.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 108 ESGKILDVGCYAGQFLAAFSPSYDK--FGVEPSQAA-------AVRAGDKGIHVLGATINDI--APEMKFDCIVSIDVVe 176
Cdd:COG0500    26 KGGRVLDLGCGTGRNLLALAARFGGrvIGIDLSPEAialararAAKAGLGNVEFLVADLAELdpLPAESFDLVVAFGVL- 104

                          90       100
                  ....*....|....*....|....*...
gi 2559584876 177 HLLDP---VDFFNKAFQLLNPNGFLIIS 201
Cdd:COG0500   105 HHLPPeerEALLRELARALKPGGVLLLS 132
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 113-198 6.62e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 55.45  E-value: 6.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 113 LDVGCYAGQFLAAFSPSYDK---FGVEPSQAAAVRA-------GDKGIHVLGATINDIA--PEMKFDCIVSIDVVEHLLD 180
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGleyTGLDISPAALEAArerlaalGLLNAVRVELFQLDLGelDPGSFDVVVASNVLHHLAD 80

                          90
                  ....*....|....*...
gi 2559584876 181 PVDFFNKAFQLLNPNGFL 198
Cdd:pfam08242  81 PRAVLRNIRRLLKPGGVL 98
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 107-203 8.99e-10

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 56.48  E-value: 8.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 107 LESG-KILDVGCYAGQFLAAFSpsyDKFGVE-------PSQAAAVRA------GDKGIHVLGATINDIAPEMKFDCIVSI 172
Cdd:COG2230    49 LKPGmRVLDIGCGWGGLALYLA---RRYGVRvtgvtlsPEQLEYAREraaeagLADRVEVRLADYRDLPADGQFDAIVSI 125

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2559584876 173 DVVEHLLDPV--DFFNKAFQLLNPNGFLIISTG 203
Cdd:COG2230   126 GMFEHVGPENypAYFAKVARLLKPGGRLLLHTP 158
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 112-196 1.65e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.41  E-value: 1.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 112 ILDVGCYAGQFLAAFSPSYDK--FGVEPSQA----AAVRAGDKG--IHVLGATINDIA-PEMKFDCIVSIDVVEHLLDP- 181
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGArvTGVDLSPEmlerARERAAEAGlnVEFVQGDAEDLPfPDGSFDLVVSSGVLHHLPDPd 80

                          90
                  ....*....|....*.
gi 2559584876 182 -VDFFNKAFQLLNPNG 196
Cdd:pfam13649  81 lEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 111-201 2.42e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 51.28  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 111 KILDVGCYAGQFLAAFSPSYDK--FGVEPS-------QAAAVRAGDKGIHVLGATINDIAPEM--KFDCIVSIDVVEHLL 179
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGArvTGVDISpvalelaRKAAAALLADNVEVLKGDAEELPPEAdeSFDVIISDPPLHHLV 80

                          90       100
                  ....*....|....*....|...
gi 2559584876 180 -DPVDFFNKAFQLLNPNGFLIIS 201
Cdd:cd02440    81 eDLARFLEEARRLLKPGGVLVLT 103
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
107-202 7.76e-06

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 46.77  E-value: 7.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 107 LESGKILDVGCYAGQFL---AAFSPsydKF--GVEPS-----QAAAVR---AGDKGIHVLGATINDIAPEMKFDCIVSID 173
Cdd:PRK15068  121 LKGRTVLDVGCGNGYHMwrmLGAGA---KLvvGIDPSqlflcQFEAVRkllGNDQRAHLLPLGIEQLPALKAFDTVFSMG 197

                          90       100
                  ....*....|....*....|....*....
gi 2559584876 174 VVEHLLDPVDFFNKAFQLLNPNGFLIIST 202
Cdd:PRK15068  198 VLYHRRSPLDHLKQLKDQLVPGGELVLET 226
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 109-200 1.81e-05

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 44.50  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 109 SGKILDVGCYAG---QFLAAFSPSY-------DKFGVEPSQAAAVRAGDKGIHVLGATINDIAPEMKFDCIVS------- 171
Cdd:pfam05175  32 SGKVLDLGCGAGvlgAALAKESPDAeltmvdiNARALESARENLAANGLENGEVVASDVYSGVEDGKFDLIISnppfhag 111

                          90       100
                  ....*....|....*....|....*....
gi 2559584876 172 IDVVEHLLDpvDFFNKAFQLLNPNGFLII 200
Cdd:pfam05175 112 LATTYNVAQ--RFIADAKRHLRPGGELWI 138
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 111-227 2.23e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 43.56  E-value: 2.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 111 KILDVGC---YAGQFLAAFSPS--------YDKFGVEPSQAAAVRAGDKGIHVLGATINDIA---PEMKFDCIVSIDVVE 176
Cdd:pfam13847   6 RVLDLGCgtgHLSFELAEELGPnaevvgidISEEAIEKARENAQKLGFDNVEFEQGDIEELPellEDDKFDVVISNCVLN 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2559584876 177 HLLDPVDFFNKAFQLLNPNGFLIISTGNPSSFAWRHIFKSRFWYVTNAEHV 227
Cdd:pfam13847  86 HIPDPDKVLQEILRVLKPGGRLIISDPDSLAELPAHVKEDSTYYAGCVGGA 136
PLN02396 PLN02396
hexaprenyldihydroxybenzoate methyltransferase
 107-210 3.17e-05

hexaprenyldihydroxybenzoate methyltransferase


Pssm-ID: 178018 [Multi-domain]  Cd Length: 322  Bit Score: 45.11  E-value: 3.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 107 LESGKILDVGCYAGqflaAFSPSYDKFGvepSQAAAVRAGDKGIHV----------------LGATINDIAPEM-KFDCI 169
Cdd:PLN02396  130 FEGLKFIDIGCGGG----LLSEPLARMG---ATVTGVDAVDKNVKIarlhadmdpvtstieyLCTTAEKLADEGrKFDAV 202

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2559584876 170 VSIDVVEHLLDPVDFFNKAFQLLNPNGFLIISTGNPSSFAW 210
Cdd:PLN02396  203 LSLEVIEHVANPAEFCKSLSALTIPNGATVLSTINRTMRAY 243
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 108-200 7.75e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 39.79  E-value: 7.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 108 ESGKILDVGC---YAGQFLAAFSPS-----YDK--FGVEPSQAAAVRAGDKGIHVLGATINDIAPEMKFDCIVS------ 171
Cdd:COG2813    49 LGGRVLDLGCgygVIGLALAKRNPEarvtlVDVnaRAVELARANAAANGLENVEVLWSDGLSGVPDGSFDLILSnppfha 128

                          90       100       110
                  ....*....|....*....|....*....|
gi 2559584876 172 -IDVVEHLLDpvDFFNKAFQLLNPNGFLII 200
Cdd:COG2813   129 gRAVDKEVAH--ALIADAARHLRPGGELWL 156
PLN02556 PLN02556
cysteine synthase/L-3-cyanoalanine synthase
 79-211 1.29e-03

cysteine synthase/L-3-cyanoalanine synthase


Pssm-ID: 178171 [Multi-domain]  Cd Length: 368  Bit Score: 39.94  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876  79 YESVNSDIWEDdALRKDQILVHSAISHVLESGkildvgcyAGQFLAAFSPSYDKFGVEPSQAAAVRAGDKGIHVLGATIN 158
Cdd:PLN02556  202 FETTGPEIWED-TLGQVDIFVMGIGSGGTVSG--------VGKYLKSKNPNVKIYGVEPAESNVLNGGKPGPHHITGNGV 272

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2559584876 159 DIAPEmkfdcIVSIDVVEHLLD--PVDFFNKAFQLLNPNGFLI-ISTGNPSSFAWR 211
Cdd:PLN02556  273 GFKPD-----ILDMDVMEKVLEvsSEDAVNMARELALKEGLMVgISSGANTVAALR 323
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 108-252 3.41e-03

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 38.41  E-value: 3.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 108 ESGKILDVGCYAGQFLAAFSPSYDK--FGVEPSQA----AAVRAGDKGIHVLGAtiNDIA----PEMKFDCIVSIDVVEH 177
Cdd:PTZ00098   52 ENSKVLDIGSGLGGGCKYINEKYGAhvHGVDICEKmvniAKLRNSDKNKIEFEA--NDILkkdfPENTFDMIYSRDAILH 129

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2559584876 178 L--LDPVDFFNKAFQLLNPNGFLIISTGNPSSFA-WRHIFKSrfwYVTNAEHVSFPSQKFiknlthklgGEVVEVTNF 252
Cdd:PTZ00098  130 LsyADKKKLFEKCYKWLKPNGILLITDYCADKIEnWDEEFKA---YIKKRKYTLIPIQEY---------GDLIKSCNF 195
PRK08317 PRK08317
hypothetical protein; Provisional
 99-211 5.02e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 37.61  E-value: 5.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876  99 VHSAIsHVLESGKILDVGCYAGQFLAAF----SPSYDKFGVEPSQA----AAVRAGDKGIHVlgATINDIA-----PEMK 165
Cdd:PRK08317   11 TFELL-AVQPGDRVLDVGCGPGNDARELarrvGPEGRVVGIDRSEAmlalAKERAAGLGPNV--EFVRGDAdglpfPDGS 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2559584876 166 FDCIVSIDVVEHLLDPVDFFNKAFQLLNPNGFLIISTGNPSSFAWR 211
Cdd:PRK08317   88 FDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDTDWDTLVWH 133
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 105-217 6.43e-03

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 37.27  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2559584876 105 HVLESGKILDVGCYAGQFLAAFSPSYDKfgvepsqaaavragdkgIHVLGatiNDIAPEM-------------------- 164
Cdd:TIGR02072  31 GIFIPASVLDIGCGTGYLTRALLKRFPQ-----------------AEFIA---LDISAGMlaqaktklsenvqficgdae 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2559584876 165 -------KFDCIVSIDVVEHLLDPVDFFNKAFQLLNPNGFLIISTGNPSSFA-WRHIFKSR 217
Cdd:TIGR02072  91 klpledsSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHeLRQSFGQH 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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