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Conserved domains on  [gi|2564918447|ref|WP_306120359|]
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MULTISPECIES: phosphoribosyltransferase [unclassified Roseitalea]

Protein Classification

phosphoribosyltransferase( domain architecture ID 10004949)

phosphoribosyltransferase catalyzes the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG1926 COG1926
Predicted phosphoribosyltransferase [General function prediction only];
4-213 1.60e-84

Predicted phosphoribosyltransferase [General function prediction only];


:

Pssm-ID: 441529  Cd Length: 209  Bit Score: 249.61  E-value: 1.60e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564918447   4 FADRIEAGQALARRLEHVDTAGAVVVGLPRGGVPVAAVVAKALGLPMDVLLIRKVGAPGHRELAVGAVSDGhaMQVTVNE 83
Cdd:COG1926     2 FRDRTDAGRQLAERLAAYRGEDPVVLALPRGGVPVAAEVARALGAPLDVLVVRKIGAPGNPELAIGAVAED--GVVVLNE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564918447  84 GIARDLGLSRDQVIELARAELPELERRRKLYFADHPAVPLKGRTVILVDDGVATGATAREALRLVRQSGPARIVLALPVA 163
Cdd:COG1926    80 DLIRRLGISEEYIEAEKAREREELERRRRRYRGGRPPPDLKGRTVILVDDGIATGATMRAALRALRRQGPARIVVAVPVA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2564918447 164 PPSTVARLAEEADEVVCVLQPDPFFAVGAYYDDFRQVDDVEVVEALRRAQ 213
Cdd:COG1926   160 PPDTLEELRREADEVVCLETPEPFRAVGQFYEDFPQVSDEEVIALLAQAR 209
 
Name Accession Description Interval E-value
COG1926 COG1926
Predicted phosphoribosyltransferase [General function prediction only];
4-213 1.60e-84

Predicted phosphoribosyltransferase [General function prediction only];


Pssm-ID: 441529  Cd Length: 209  Bit Score: 249.61  E-value: 1.60e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564918447   4 FADRIEAGQALARRLEHVDTAGAVVVGLPRGGVPVAAVVAKALGLPMDVLLIRKVGAPGHRELAVGAVSDGhaMQVTVNE 83
Cdd:COG1926     2 FRDRTDAGRQLAERLAAYRGEDPVVLALPRGGVPVAAEVARALGAPLDVLVVRKIGAPGNPELAIGAVAED--GVVVLNE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564918447  84 GIARDLGLSRDQVIELARAELPELERRRKLYFADHPAVPLKGRTVILVDDGVATGATAREALRLVRQSGPARIVLALPVA 163
Cdd:COG1926    80 DLIRRLGISEEYIEAEKAREREELERRRRRYRGGRPPPDLKGRTVILVDDGIATGATMRAALRALRRQGPARIVVAVPVA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2564918447 164 PPSTVARLAEEADEVVCVLQPDPFFAVGAYYDDFRQVDDVEVVEALRRAQ 213
Cdd:COG1926   160 PPDTLEELRREADEVVCLETPEPFRAVGQFYEDFPQVSDEEVIALLAQAR 209
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 10-182 1.65e-11

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 59.72  E-value: 1.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564918447  10 AGQALARRLEHVDTAGAVVVGLPRGGVPVAAVVAKALGLPMDVLLIRKVGAPGHRELAVGavsdghamqvtvnegiardl 89
Cdd:cd06223     1 AGRLLAEEIREDLLEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEPYG-------------------- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564918447  90 glsrdqvielaraelpelerrrklyFADHPAVPLKGRTVILVDDGVATGATAREALRLVRQSGPARIVLALPVAPPSTVA 169
Cdd:cd06223    61 -------------------------LELPLGGDVKGKRVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA 115

                         170
                  ....*....|...
gi 2564918447 170 RLAEEADEVVCVL 182
Cdd:cd06223   116 RELASPGDPVYSL 128
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 123-196 5.97e-07

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 47.36  E-value: 5.97e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2564918447 123 LKGRTVILVDDGVATGATAREALRLVRQSGPARIVLALPVAPPSTvarlAEEADEVVCVLQPDPFFAVGAYYDD 196
Cdd:pfam00156  80 LKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDKPAG----TEPKDKYDKRVDDWIVFVVGFGLDE 149
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 123-178 3.06e-05

uracil phosphoribosyltransferase; Reviewed


Pssm-ID: 234653  Cd Length: 209  Bit Score: 43.54  E-value: 3.06e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2564918447 123 LKGRTVILVDDGVATGATAREALRLVRQSGPARIVLALPVAPPSTVARLAEEADEV 178
Cdd:PRK00129  122 IDERTVIVVDPMLATGGSAIAAIDLLKKRGAKNIKVLCLVAAPEGIKALEEAHPDV 177
 
Name Accession Description Interval E-value
COG1926 COG1926
Predicted phosphoribosyltransferase [General function prediction only];
4-213 1.60e-84

Predicted phosphoribosyltransferase [General function prediction only];


Pssm-ID: 441529  Cd Length: 209  Bit Score: 249.61  E-value: 1.60e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564918447   4 FADRIEAGQALARRLEHVDTAGAVVVGLPRGGVPVAAVVAKALGLPMDVLLIRKVGAPGHRELAVGAVSDGhaMQVTVNE 83
Cdd:COG1926     2 FRDRTDAGRQLAERLAAYRGEDPVVLALPRGGVPVAAEVARALGAPLDVLVVRKIGAPGNPELAIGAVAED--GVVVLNE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564918447  84 GIARDLGLSRDQVIELARAELPELERRRKLYFADHPAVPLKGRTVILVDDGVATGATAREALRLVRQSGPARIVLALPVA 163
Cdd:COG1926    80 DLIRRLGISEEYIEAEKAREREELERRRRRYRGGRPPPDLKGRTVILVDDGIATGATMRAALRALRRQGPARIVVAVPVA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2564918447 164 PPSTVARLAEEADEVVCVLQPDPFFAVGAYYDDFRQVDDVEVVEALRRAQ 213
Cdd:COG1926   160 PPDTLEELRREADEVVCLETPEPFRAVGQFYEDFPQVSDEEVIALLAQAR 209
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 10-182 1.65e-11

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 59.72  E-value: 1.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564918447  10 AGQALARRLEHVDTAGAVVVGLPRGGVPVAAVVAKALGLPMDVLLIRKVGAPGHRELAVGavsdghamqvtvnegiardl 89
Cdd:cd06223     1 AGRLLAEEIREDLLEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEPYG-------------------- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564918447  90 glsrdqvielaraelpelerrrklyFADHPAVPLKGRTVILVDDGVATGATAREALRLVRQSGPARIVLALPVAPPSTVA 169
Cdd:cd06223    61 -------------------------LELPLGGDVKGKRVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA 115

                         170
                  ....*....|...
gi 2564918447 170 RLAEEADEVVCVL 182
Cdd:cd06223   116 RELASPGDPVYSL 128
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 123-196 5.97e-07

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 47.36  E-value: 5.97e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2564918447 123 LKGRTVILVDDGVATGATAREALRLVRQSGPARIVLALPVAPPSTvarlAEEADEVVCVLQPDPFFAVGAYYDD 196
Cdd:pfam00156  80 LKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDKPAG----TEPKDKYDKRVDDWIVFVVGFGLDE 149
ComFC COG1040
DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General ...
 83-160 1.15e-06

DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General function prediction only];


Pssm-ID: 440662 [Multi-domain]  Cd Length: 196  Bit Score: 47.51  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564918447  83 EGIARDLGLS-RDQVIELAR-----AELPELERRRKLY--FADHPAVPLKGRTVILVDDGVATGATAREALRLVRQSGPA 154
Cdd:COG1040   105 RALARALGIPvLPDLLRRVRatpsqAGLSRAERRRNLRgaFAVRPPARLAGKHVLLVDDVLTTGATLAEAARALKAAGAA 184


                  ....*..
gi 2564918447 155 RI-VLAL 160
Cdd:COG1040   185 RVdVLVL 191
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 123-178 3.06e-05

uracil phosphoribosyltransferase; Reviewed


Pssm-ID: 234653  Cd Length: 209  Bit Score: 43.54  E-value: 3.06e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2564918447 123 LKGRTVILVDDGVATGATAREALRLVRQSGPARIVLALPVAPPSTVARLAEEADEV 178
Cdd:PRK00129  122 IDERTVIVVDPMLATGGSAIAAIDLLKKRGAKNIKVLCLVAAPEGIKALEEAHPDV 177
PRK11595 PRK11595
DNA utilization protein GntX; Provisional
 109-154 3.99e-05

DNA utilization protein GntX; Provisional


Pssm-ID: 183221 [Multi-domain]  Cd Length: 227  Bit Score: 43.10  E-value: 3.99e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2564918447 109 RRRKLYFADHPAVPLKGRTVILVDDGVATGATAREALRLVRQSGPA 154
Cdd:PRK11595  171 RKRNLKNAFRLELPVQGQHMAIVDDVVTTGSTVAEIAQLLLRNGAA 216
UPRTase pfam14681
Uracil phosphoribosyltransferase; This family includes the enzyme uracil ...
 123-178 2.12e-04

Uracil phosphoribosyltransferase; This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis.


Pssm-ID: 434124  Cd Length: 204  Bit Score: 40.94  E-value: 2.12e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2564918447 123 LKGRTVILVDDGVATGATAREALRLVRQSG--PARIVLALPVAPPSTVARLAEEADEV 178
Cdd:pfam14681 116 ISDRTVILLDPMLATGGSAIAAIQVLREHGvpEENIVVLSVIAAPEGLHRLAAAFPDV 173
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 124-180 9.34e-04

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 39.27  E-value: 9.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564918447 124 KGRTVILVDDGVATGATAREALRLVRQSGPARIVLA--LPVAPPSTVARLAE-EADEVVC 180
Cdd:COG0462   210 EGKTCIIVDDMIDTGGTLVEAAEALKEAGAKSVYAAatHGVLSGPAVERLENsPIDELVV 269
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 123-181 9.53e-04

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 39.34  E-value: 9.53e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2564918447 123 LKGRTVILVDDGVATGATAREALRLVRQSGpARIVLAL---PVAPPSTVARLAEEADEVVCV 181
Cdd:PRK02812  228 VKGKTAILVDDMIDTGGTICEGARLLRKEG-AKQVYACathAVFSPPAIERLSSGLFEEVIV 288
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 118-159 1.45e-03

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 38.08  E-value: 1.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2564918447 118 HPAVPLKGRTVILVDDGVATGATAREALRLVRQSGPARIVLA 159
Cdd:COG0634    84 DLDEDIEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVKIA 125
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
124-179 1.84e-03

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 38.39  E-value: 1.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2564918447 124 KGRTVILVDDGVATGATAREALRLVRQSGPARIVLAL--PVAPPSTVARLAEE-ADEVV 179
Cdd:PRK03092  200 EGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAAthGVLSGPAAERLKNCgAREVV 258
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 123-179 2.56e-03

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 37.97  E-value: 2.56e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2564918447 123 LKGRTVILVDDGVATGATAREALRLVRQSGPARIVLAL--PVAPPSTVARLAE-EADEVV 179
Cdd:PRK00934  202 VKGKDVLIVDDIISTGGTMATAIKILKEQGAKKVYVACvhPVLVGDAILKLYNaGVDEII 261
PRK05205 PRK05205
bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;
121-186 3.03e-03

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;


Pssm-ID: 235365  Cd Length: 176  Bit Score: 37.03  E-value: 3.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2564918447 121 VPLKGRTVILVDDGVATGATAREALRLVRQSG-PARIVLA---------LPVAPPSTVARLAEEADEVVCVLQPDP 186
Cdd:PRK05205   91 FDIEGKRVILVDDVLYTGRTIRAALDALFDYGrPARVQLAvlvdrghreLPIRADYVGKNIPTSRDERVVVRLAEV 166
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 124-157 5.61e-03

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 36.21  E-value: 5.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2564918447 124 KGRTVILVDDGVATGATAREALRLVRQSGpARIV 157
Cdd:COG0503   111 PGDRVLIVDDLLATGGTAKAAIKLVEEAG-AEVV 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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