MULTISPECIES: glycosyltransferase [unclassified Roseitalea]
Protein Classification
glycosyltransferase family protein( domain architecture ID 56)
glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| Glycosyltransferase_GTB-type super family | cl10013 | glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ... |
76-395 | 1.75e-32 | ||||||
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The actual alignment was detected with superfamily member cd03794: Pssm-ID: 471961 [Multi-domain] Cd Length: 391 Bit Score: 126.30 E-value: 1.75e-32
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| Name | Accession | Description | Interval | E-value | ||||||
| GT4_WbuB-like | cd03794 | Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ... |
76-395 | 1.75e-32 | ||||||
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase. Pssm-ID: 340825 [Multi-domain] Cd Length: 391 Bit Score: 126.30 E-value: 1.75e-32
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| RfaB | COG0438 | Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ... |
312-396 | 5.64e-09 | ||||||
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440207 [Multi-domain] Cd Length: 123 Bit Score: 53.84 E-value: 5.64e-09
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| Glyco_transf_4 | pfam13439 | Glycosyltransferase Family 4; |
21-200 | 1.18e-07 | ||||||
Glycosyltransferase Family 4; Pssm-ID: 463877 [Multi-domain] Cd Length: 169 Bit Score: 51.38 E-value: 1.18e-07
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| Name | Accession | Description | Interval | E-value | ||||||
| GT4_WbuB-like | cd03794 | Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ... |
76-395 | 1.75e-32 | ||||||
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase. Pssm-ID: 340825 [Multi-domain] Cd Length: 391 Bit Score: 126.30 E-value: 1.75e-32
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| GT4_PimA-like | cd03801 | phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ... |
17-392 | 1.56e-19 | ||||||
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea. Pssm-ID: 340831 [Multi-domain] Cd Length: 366 Bit Score: 89.13 E-value: 1.56e-19
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| GT4_WlbH-like | cd03798 | Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ... |
13-394 | 4.71e-10 | ||||||
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS. Pssm-ID: 340828 [Multi-domain] Cd Length: 376 Bit Score: 60.86 E-value: 4.71e-10
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| GT4_WavL-like | cd03819 | Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ... |
98-382 | 2.60e-09 | ||||||
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core. Pssm-ID: 340846 [Multi-domain] Cd Length: 345 Bit Score: 58.14 E-value: 2.60e-09
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| RfaB | COG0438 | Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ... |
312-396 | 5.64e-09 | ||||||
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440207 [Multi-domain] Cd Length: 123 Bit Score: 53.84 E-value: 5.64e-09
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| Glyco_transf_4 | pfam13439 | Glycosyltransferase Family 4; |
21-200 | 1.18e-07 | ||||||
Glycosyltransferase Family 4; Pssm-ID: 463877 [Multi-domain] Cd Length: 169 Bit Score: 51.38 E-value: 1.18e-07
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| GT4-like | cd05844 | glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ... |
152-376 | 4.09e-07 | ||||||
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. Pssm-ID: 340860 [Multi-domain] Cd Length: 365 Bit Score: 51.68 E-value: 4.09e-07
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| GT4_AviGT4-like | cd03802 | UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ... |
310-394 | 5.75e-07 | ||||||
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue. Pssm-ID: 340832 [Multi-domain] Cd Length: 333 Bit Score: 51.13 E-value: 5.75e-07
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| Glyco_trans_4_4 | pfam13579 | Glycosyl transferase 4-like domain; |
95-194 | 1.41e-06 | ||||||
Glycosyl transferase 4-like domain; Pssm-ID: 433325 [Multi-domain] Cd Length: 158 Bit Score: 47.78 E-value: 1.41e-06
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| GT4_sucrose_synthase | cd03800 | sucrose-phosphate synthase and similar proteins; This family is most closely related to the ... |
83-387 | 1.60e-05 | ||||||
sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light. Pssm-ID: 340830 [Multi-domain] Cd Length: 398 Bit Score: 46.85 E-value: 1.60e-05
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| GT4_WbnK-like | cd03807 | Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ... |
95-392 | 4.01e-05 | ||||||
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis. Pssm-ID: 340836 [Multi-domain] Cd Length: 362 Bit Score: 45.39 E-value: 4.01e-05
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| GT4-like | cd03813 | glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ... |
93-392 | 1.31e-04 | ||||||
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes. Pssm-ID: 340841 [Multi-domain] Cd Length: 474 Bit Score: 43.86 E-value: 1.31e-04
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| GT4_WcaC-like | cd03825 | putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ... |
312-394 | 1.64e-04 | ||||||
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis. Pssm-ID: 340851 [Multi-domain] Cd Length: 364 Bit Score: 43.47 E-value: 1.64e-04
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| GT4_BshA-like | cd04962 | N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ... |
312-394 | 2.29e-04 | ||||||
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes. Pssm-ID: 340859 [Multi-domain] Cd Length: 370 Bit Score: 43.11 E-value: 2.29e-04
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| Glycos_transf_1 | pfam00534 | Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ... |
312-377 | 2.01e-03 | ||||||
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family. Pssm-ID: 425737 [Multi-domain] Cd Length: 158 Bit Score: 38.41 E-value: 2.01e-03
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| GT4-like | cd03814 | glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ... |
310-396 | 8.27e-03 | ||||||
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes. Pssm-ID: 340842 [Multi-domain] Cd Length: 365 Bit Score: 38.04 E-value: 8.27e-03
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