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Conserved domains on  [gi|2569301562|ref|WP_306724740|]
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AraC family transcriptional regulator [Pseudoalteromonas sp. 20-92]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12071874)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) DNA-binding domain, may regulate the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|15808743|9409145|33837749|11282467

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraC_N pfam06719
AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of ...
 28-184 1.21e-42

AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.


:

Pssm-ID: 461994  Cd Length: 152  Bit Score: 143.80  E-value: 1.21e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562  28 IPGVYFHRATKSSPRQPLIYNSGIIIVGQGHKIIHFPEHQIRYGAGDYLVLGVPVPLEC---EAFTDNdlPVMGIAIDIN 104
Cdd:pfam06719   2 IPGLTLFRTSEPTEPTPVVYEPSLCIVAQGAKRVHLGDETYEYDPGEYLVVSVDLPVTGevtEASPEE--PYLGLALDLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 105 PAMLHKLVNQIMQHKPLSASSSsssssaqigAVQSATLDTAMELITHRLLTVLNNPLEAEIFGEDIVKELVYRVLCGPQG 184
Cdd:pfam06719  80 PALLAELLLEAPPPGPPPRAGR---------GLAVSPLDEELLDAVLRLLRLLDTPEDIPVLAPLILREILYRLLTGPQG 150
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
214-295 1.81e-27

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 102.25  E-value: 1.81e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562  214 QITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKELITASGSKANEAALRVGYTSPSQFSREFKRHFNKTP 293
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ..
gi 2569301562  294 SE 295
Cdd:smart00342  81 SE 82
 
Name Accession Description Interval E-value
AraC_N pfam06719
AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of ...
 28-184 1.21e-42

AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.


Pssm-ID: 461994  Cd Length: 152  Bit Score: 143.80  E-value: 1.21e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562  28 IPGVYFHRATKSSPRQPLIYNSGIIIVGQGHKIIHFPEHQIRYGAGDYLVLGVPVPLEC---EAFTDNdlPVMGIAIDIN 104
Cdd:pfam06719   2 IPGLTLFRTSEPTEPTPVVYEPSLCIVAQGAKRVHLGDETYEYDPGEYLVVSVDLPVTGevtEASPEE--PYLGLALDLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 105 PAMLHKLVNQIMQHKPLSASSSsssssaqigAVQSATLDTAMELITHRLLTVLNNPLEAEIFGEDIVKELVYRVLCGPQG 184
Cdd:pfam06719  80 PALLAELLLEAPPPGPPPRAGR---------GLAVSPLDEELLDAVLRLLRLLDTPEDIPVLAPLILREILYRLLTGPQG 150
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
214-295 1.81e-27

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 102.25  E-value: 1.81e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562  214 QITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKELITASGSKANEAALRVGYTSPSQFSREFKRHFNKTP 293
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ..
gi 2569301562  294 SE 295
Cdd:smart00342  81 SE 82
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
58-302 9.40e-25

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 100.24  E-value: 9.40e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562  58 HKIIHFPEHQIRYGAGDYLVLGVPVPLECEAFTDNDLPVMGIAIDINPAMLHKLVNQIMQHKPLSASSSSSSSSAQIGAV 137
Cdd:COG2207    13 LLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLV 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 138 QSATLDTAMELITHRLLTVLNNPLEAEIFGEDIVKELVYRVLCGPQGNTLIGLAMHDGHYARIARTLSTMHSSYAnQITV 217
Cdd:COG2207    93 GLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL-LLTL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 218 EGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKELITASGSKANEAALRVGYTSPSQFSREFKRHFNKTPSEVL 297
Cdd:COG2207   172 EELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYR 251


                  ....*
gi 2569301562 298 TQLHS 302
Cdd:COG2207   252 KRLRA 256
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 190-295 9.93e-24

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 98.31  E-value: 9.93e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 190 LAMHDGHYARIARTLSTMHSSYANQITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKELITASGSKANEA 269
Cdd:COG4977   202 LVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEI 281

                          90       100
                  ....*....|....*....|....*.
gi 2569301562 270 ALRVGYTSPSQFSREFKRHFNKTPSE 295
Cdd:COG4977   282 AAACGFGSASHFRRAFRRRFGVSPSA 307
HTH_18 pfam12833
Helix-turn-helix domain;
220-299 8.50e-22

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 86.87  E-value: 8.50e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 220 LAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKE-LITASGSKANEAALRVGYTSPSQFSREFKRHFNKTPSEVLT 298
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRlLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 2569301562 299 Q 299
Cdd:pfam12833  81 R 81
ftrA PRK09393
transcriptional activator FtrA; Provisional
 198-294 2.21e-12

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 66.53  E-value: 2.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 198 ARIARTLSTMHSSYANQITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKELITASGSKANEAALRVGYTS 277
Cdd:PRK09393  218 DRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGS 297

                          90
                  ....*....|....*..
gi 2569301562 278 PSQFSREFKRHFNKTPS 294
Cdd:PRK09393  298 EESLRHHFRRRAATSPA 314
 
Name Accession Description Interval E-value
AraC_N pfam06719
AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of ...
 28-184 1.21e-42

AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.


Pssm-ID: 461994  Cd Length: 152  Bit Score: 143.80  E-value: 1.21e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562  28 IPGVYFHRATKSSPRQPLIYNSGIIIVGQGHKIIHFPEHQIRYGAGDYLVLGVPVPLEC---EAFTDNdlPVMGIAIDIN 104
Cdd:pfam06719   2 IPGLTLFRTSEPTEPTPVVYEPSLCIVAQGAKRVHLGDETYEYDPGEYLVVSVDLPVTGevtEASPEE--PYLGLALDLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 105 PAMLHKLVNQIMQHKPLSASSSsssssaqigAVQSATLDTAMELITHRLLTVLNNPLEAEIFGEDIVKELVYRVLCGPQG 184
Cdd:pfam06719  80 PALLAELLLEAPPPGPPPRAGR---------GLAVSPLDEELLDAVLRLLRLLDTPEDIPVLAPLILREILYRLLTGPQG 150
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
214-295 1.81e-27

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 102.25  E-value: 1.81e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562  214 QITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKELITASGSKANEAALRVGYTSPSQFSREFKRHFNKTP 293
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ..
gi 2569301562  294 SE 295
Cdd:smart00342  81 SE 82
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
58-302 9.40e-25

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 100.24  E-value: 9.40e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562  58 HKIIHFPEHQIRYGAGDYLVLGVPVPLECEAFTDNDLPVMGIAIDINPAMLHKLVNQIMQHKPLSASSSSSSSSAQIGAV 137
Cdd:COG2207    13 LLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLV 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 138 QSATLDTAMELITHRLLTVLNNPLEAEIFGEDIVKELVYRVLCGPQGNTLIGLAMHDGHYARIARTLSTMHSSYAnQITV 217
Cdd:COG2207    93 GLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL-LLTL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 218 EGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKELITASGSKANEAALRVGYTSPSQFSREFKRHFNKTPSEVL 297
Cdd:COG2207   172 EELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYR 251


                  ....*
gi 2569301562 298 TQLHS 302
Cdd:COG2207   252 KRLRA 256
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 190-295 9.93e-24

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 98.31  E-value: 9.93e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 190 LAMHDGHYARIARTLSTMHSSYANQITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKELITASGSKANEA 269
Cdd:COG4977   202 LVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEI 281

                          90       100
                  ....*....|....*....|....*.
gi 2569301562 270 ALRVGYTSPSQFSREFKRHFNKTPSE 295
Cdd:COG4977   282 AAACGFGSASHFRRAFRRRFGVSPSA 307
HTH_18 pfam12833
Helix-turn-helix domain;
220-299 8.50e-22

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 86.87  E-value: 8.50e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 220 LAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKE-LITASGSKANEAALRVGYTSPSQFSREFKRHFNKTPSEVLT 298
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRlLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 2569301562 299 Q 299
Cdd:pfam12833  81 R 81
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 191-295 5.49e-19

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 85.88  E-value: 5.49e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 191 AMHDGHYARIARTLSTMHSSYANQITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKELITASGSKAnEAA 270
Cdd:COG2169    77 PGSPPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLSVT-DAA 155

                          90       100
                  ....*....|....*....|....*
gi 2569301562 271 LRVGYTSPSQFSREFKRHFNKTPSE 295
Cdd:COG2169   156 YAAGFGSLSRFYEAFKKLLGMTPSA 180
ftrA PRK09393
transcriptional activator FtrA; Provisional
 198-294 2.21e-12

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 66.53  E-value: 2.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 198 ARIARTLSTMHSSYANQITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKELITASGSKANEAALRVGYTS 277
Cdd:PRK09393  218 DRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGS 297

                          90
                  ....*....|....*..
gi 2569301562 278 PSQFSREFKRHFNKTPS 294
Cdd:PRK09393  298 EESLRHHFRRRAATSPA 314
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
194-296 4.19e-11

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 62.39  E-value: 4.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 194 DGHYARIARTLSTMHSSYANQITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKELITASGSKANEAALRV 273
Cdd:PRK13503  167 ENSDARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRC 246

                          90       100
                  ....*....|....*....|...
gi 2569301562 274 GYTSPSQFSREFKRHFNKTPSEV 296
Cdd:PRK13503  247 GFGDSNHFSTLFRREFSWSPRDI 269
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
196-295 6.17e-08

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 53.05  E-value: 6.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 196 HYARIARTLSTMH---SSYANQITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKELITASGSKANEAALR 272
Cdd:PRK10572  178 HPPMDPRVREACQyisDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRN 257

                          90       100
                  ....*....|....*....|...
gi 2569301562 273 VGYTSPSQFSREFKRHFNKTPSE 295
Cdd:PRK10572  258 VGYDDQLYFSRVFKKCTGASPSE 280
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 214-295 1.92e-07

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 51.57  E-value: 1.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 214 QITVEGLAEDVNMSVSSFHRAFKQiTFESPLQYLKKVRLAKAKELIT--ASGSKANEAALRVGYTSPSQFSREFKRHFNK 291
Cdd:PRK09685  214 ILRPEWIAGELGISVRSLYRLFAE-QGLVVAQYIRNRRLDRCADDLRpaADDEKITSIAYKWGFSDSSHFSTAFKQRFGV 292


                  ....
gi 2569301562 292 TPSE 295
Cdd:PRK09685  293 SPGE 296
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 207-248 8.57e-07

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 44.84  E-value: 8.57e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2569301562 207 MHSSYANQITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLK 248
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 209-302 1.09e-06

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 49.29  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 209 SSYANQITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLKkVRLAKAKELITASGSKANEAALRVGYTSPSQFSREFKRH 288
Cdd:PRK15186  192 SDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLN-ARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKH 270

                          90
                  ....*....|....
gi 2569301562 289 FNKTPSEVLTQLHS 302
Cdd:PRK15186  271 FKTTPSEFLAFLSS 284
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
231-295 2.79e-06

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 45.30  E-value: 2.79e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2569301562 231 FHRAFKQITFESPLQYLKKVRLAKAKELITASGSKANEAALRVGYTSPSQFSREFKRHFNKTPSE 295
Cdd:PRK10219   38 LQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSD 102
PRK10130 PRK10130
HTH-type transcriptional regulator EutR;
193-299 1.22e-05

HTH-type transcriptional regulator EutR;


Pssm-ID: 182258 [Multi-domain]  Cd Length: 350  Bit Score: 46.06  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 193 HDGHYARIARTLSTMHSSYANQITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRL-AKAKELIT--ASGSKANEA 269
Cdd:PRK10130  235 HQSYRRLLSRAREYVLENMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLnAVRRELISpwSQSTTVKDA 314

                          90       100       110
                  ....*....|....*....|....*....|
gi 2569301562 270 ALRVGYTSPSQFSREFKRHFNKTPSEVLTQ 299
Cdd:PRK10130  315 AMQWGFWHLGQFATDYQQLFAEKPSLTLHQ 344
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
204-294 2.67e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 44.90  E-value: 2.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 204 LSTMHSSYANQITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKELITASGSKANEAALRVGYTSPSQFSR 283
Cdd:PRK13501  182 MSALQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSA 261

                          90
                  ....*....|.
gi 2569301562 284 EFKRHFNKTPS 294
Cdd:PRK13501  262 VFTREAGMTPR 272
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
215-293 9.84e-05

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 43.24  E-value: 9.84e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2569301562 215 ITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKELItASGSKANEAALRVGYTSPSQFSREFKRHFNKTP 293
Cdd:PRK15435  100 VTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLREAL-AKGESVTTSILNAGFPDSSSYYRKADETLGMTA 177
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 202-294 2.18e-04

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 42.29  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 202 RTLSTMHSSYANQITVEGLAEDVNMSVSSFHR--AFKQITFESplQYLKkVRLAKAKELITASGSKANEAALRVGYTSPS 279
Cdd:PRK15185  210 RVYNIISSSPSRQWKLTDVADHIFMSTSTLKRklAEEGTSFSD--IYLS-ARMNQAAKLLRIGNHNVNAVALKCGYDSTS 286

                          90
                  ....*....|....*
gi 2569301562 280 QFSREFKRHFNKTPS 294
Cdd:PRK15185  287 YFIQCFKKYFKTTPS 301
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 260-298 2.92e-04

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 37.90  E-value: 2.92e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2569301562 260 TASGSKANEAALRVGYtSPSQFSREFKRHFNKTPSEVLT 298
Cdd:pfam00165   5 LSTNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 202-295 5.31e-04

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 41.06  E-value: 5.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 202 RTLSTMHSSYANQITVEGLAEDVNMSVSSFHRAFK--QITFEsplQYLKKVRLAKAKELITASGSKANEAALRVGYTSPS 279
Cdd:PRK09978  146 RVCTVINNNIAHEWTLARIASELLMSPSLLKKKLReeETSYS---QLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVS 222

                          90
                  ....*....|....*.
gi 2569301562 280 QFSREFKRHFNKTPSE 295
Cdd:PRK09978  223 YFIYVFRNYYGMTPTE 238
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 236-296 2.41e-03

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 38.91  E-value: 2.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2569301562 236 KQITFEsplQYLKKVRLAKAKELITASGSkANEAALRVGYTSPSQFSREFKRHFNKTPSEV 296
Cdd:PRK09940  174 EQTTFS---QILLDARMQHAKNLIRVEGS-VNKIAEQCGYASTSYFIYAFRKHFGNSPKRV 230
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
196-295 2.44e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 38.88  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 196 HYARIARTLSTMHSSYANQITVEGLAEDVNMSVSSFHRAFKQITFESPLQYLKKVRLAKAKELITASGSKANEAALRVGY 275
Cdd:PRK13502  174 RETLLDKLITALANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGF 253

                          90       100
                  ....*....|....*....|
gi 2569301562 276 TSPSQFSREFKRHFNKTPSE 295
Cdd:PRK13502  254 EDSNYFSVVFTRETGMTPSQ 273
PRK15044 PRK15044
transcriptional regulator SirC; Provisional
 226-293 6.11e-03

transcriptional regulator SirC; Provisional


Pssm-ID: 185004 [Multi-domain]  Cd Length: 295  Bit Score: 37.71  E-value: 6.11e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569301562 226 MSVSSFHR--AFKQITFESPlqYLKkVRLAKAKELITASGSKANEAALRVGYTSPSQFSREFKRHFNKTP 293
Cdd:PRK15044  220 MSVSSLKRklAAEEVSFSKI--YLD-ARMNQAIKLLRMGAGNISQVATMCGYDTPSYFIAIFKRHFKITP 286
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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