|
Name |
Accession |
Description |
Interval |
E-value |
| ASKHA_ATPase_ROK_BsXylR-like |
cd24076 |
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ... |
80-392 |
1.48e-103 |
|
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.
Pssm-ID: 466926 [Multi-domain] Cd Length: 303 Bit Score: 308.34 E-value: 1.48e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 80 GCIIGIDLDVKYILIVLTDLMANVIWEKKVDVKIGESQQAIIERLIELIDKAILNAPETIRGILGIGIGVPGIVDYKKGT 159
Cdd:cd24076 1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLPASDDPDEVLAQLAALIREALAAAPDSPLGILGIGVGVPGLVDSEDGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 160 VLMAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLAGE 239
Cdd:cd24076 81 VLLAPNLGWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGFAGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 240 MGHMTINILDHQCSCGNTGCWENYASEKALFDYIHTQLIMGksdnyinkdnfNTLSALDIINYAQKGSEIAVEALKEIGR 319
Cdd:cd24076 161 IGHMTVDPDGPPCSCGNRGCWETYASERALLRAAGRLGAGG-----------EPLSLAELVEAARAGDPAALAALEEVGE 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2570555858 320 KLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKKCLVYRYHKVKIKTSKLQFHAGAIGAVSLVIS 392
Cdd:cd24076 230 YLGIGLANLVNTFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVVSRLGEDAAALGAAALAID 302
|
|
| NagC |
COG1940 |
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ... |
76-392 |
1.24e-73 |
|
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];
Pssm-ID: 441543 [Multi-domain] Cd Length: 306 Bit Score: 232.09 E-value: 1.24e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 76 NNKAGCIIGIDLDVKYILIVLTDLMANVIWEKKVDVKIGESQQAIIERLIELIDKAILNAPETIRGILGIGIGVPGIVDY 155
Cdd:COG1940 1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 156 KKGTVLMAPNLK-WENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSagigigtgiiingELYRGTV 234
Cdd:COG1940 81 ETGVVLNAPNLPgWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTlgtgigggivingKLLRGAN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 235 GLAGEMGHMTINILDHQCSCGNTGCWENYASEKALFDYIHTQLIMGKsdnyinkdnfntLSALDIINYAQKGSEIAVEAL 314
Cdd:COG1940 161 GNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELGGAEK------------LTAEELFAAARAGDPLALEVL 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2570555858 315 KEIGRKLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKKCLVYRYHKVKIKTSKLQFHAGAIGAVSLVIS 392
Cdd:COG1940 229 DEAARYLGIGLANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLGDDAGLLGAAALALE 306
|
|
| ROK |
pfam00480 |
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ... |
83-391 |
1.13e-53 |
|
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.
Pssm-ID: 395384 [Multi-domain] Cd Length: 292 Bit Score: 179.84 E-value: 1.13e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 83 IGIDLDVKYILIVLTDLMANVIWekkvDVKIGESQQAIIERLIELIDKAILNAPETIRGILGIGIGVPGIVDYKKGTVLM 162
Cdd:pfam00480 1 IGIDIGGTKIAAALFDEEGEILA----RERVPTPTTTTEETLVDAIAFFVDSAQRKFGELIAVGIGSPGLISPKYGYITN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 163 APNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLAGEMGH 242
Cdd:pfam00480 77 TPNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGH 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 243 MTINILDHQCSCGNTGCWENYASEKALFDYIHTQLimgksdnyinkdnfNTLSALDIINYAQKGSEIAVEALKEIGRKLG 322
Cdd:pfam00480 157 IQLDPNGPKCGCGNHGCLETIASGRALEKRYQQKG--------------EDLEGKDIIVLAEQGDEVAEEAVERLARYLA 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2570555858 323 VGIVNVINTFNPELVIIGNTLSLARGLiLDEILKEVEKkcLVYRYHK---VKIKTSKLQFHAGAIGAVSLVI 391
Cdd:pfam00480 223 KAIANLINLFDPQAIVLGGGVSNADGL-LEAIRSLVKK--YLNGYLPvppVIIVAASLGDNAGALGAAALAK 291
|
|
| ROK_glcA_fam |
TIGR00744 |
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ... |
153-393 |
4.01e-37 |
|
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]
Pssm-ID: 273246 [Multi-domain] Cd Length: 318 Bit Score: 136.95 E-value: 4.01e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 153 VDYKKGTVLMAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRG 232
Cdd:TIGR00744 69 VNRQRGTVYFAVNLDWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHG 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 233 TVGLAGEMGHMTInilDHQ----CSCGNTGCWENYASEKALFDYI---HTQLIMGKSDNYINKDnfNTLSALDIINYAQK 305
Cdd:TIGR00744 149 HNGVGAEIGHIRM---VPDgrllCNCGKQGCIETYASATGLVRYAkraNAKPERAEVLLALGDG--DGISAKHVFVAARQ 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 306 GSEIAVEALKEIGRKLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVeKKCLVYRYHKV-KIKTSKLQFHAGAI 384
Cdd:TIGR00744 224 GDPVAVDSYREVARWAGAGLADLASLFNPSAIVLGGGLSDAGDLLLDPIRKSY-KRWLFGGARQVaDIIAAQLGNDAGLV 302
|
....*....
gi 2570555858 385 GAVSLVISE 393
Cdd:TIGR00744 303 GAADLARTY 311
|
|
| PRK13310 |
PRK13310 |
N-acetyl-D-glucosamine kinase; Provisional |
153-344 |
4.81e-14 |
|
N-acetyl-D-glucosamine kinase; Provisional
Pssm-ID: 183967 [Multi-domain] Cd Length: 303 Bit Score: 72.33 E-value: 4.81e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 153 VDYKKGTVLMAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKW------------------FGAGIKYNNLVYvs 214
Cdd:PRK13310 68 PETEDGTLYAANVPAASGKPLRADLSARLGRDVRLDNDANCFALSEAWddeftqyplvmglilgtgVGGGLVFNGKPI-- 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 215 agigigtgiiingelyRGTVGLAGEMGHMTINI--LDH--------QCSCGNTGCWENYASEKAlFDYIHTQLimgksdn 284
Cdd:PRK13310 146 ----------------SGRSYITGEFGHMRLPVdaLTLlgwdaplrRCGCGQKGCIENYLSGRG-FEWLYQHY------- 201
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 285 yinkdNFNTLSALDIINYAQKGSEIAVEALKEIGRKLGVGIVNVINTFNPELVIIGNTLS 344
Cdd:PRK13310 202 -----YGEPLQAPEIIALYYQGDEQAVAHVERYLDLLAICLGNILTIVDPHLVVLGGGLS 256
|
|
| COG3398 |
COG3398 |
Predicted transcriptional regulator, contains two HTH domains [Transcription]; |
14-79 |
1.56e-05 |
|
Predicted transcriptional regulator, contains two HTH domains [Transcription];
Pssm-ID: 442625 [Multi-domain] Cd Length: 159 Bit Score: 44.87 E-value: 1.56e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2570555858 14 KSIVLnTIRKKGNVSRADIAHITGLNKSTVSFLVDELINEGFVREEgpgesKGGRKpIILSINNKA 79
Cdd:COG3398 100 RRILL-YLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERE-----RDGRN-VRYYLNPPE 158
|
|
| MarR_2 |
pfam12802 |
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ... |
17-62 |
2.27e-04 |
|
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.
Pssm-ID: 432797 [Multi-domain] Cd Length: 60 Bit Score: 38.72 E-value: 2.27e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 2570555858 17 VLNTIRKKGNVSRADIAHITGLNKSTVSFLVDELINEGFV-REEGPG 62
Cdd:pfam12802 10 VLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVeREPSPA 56
|
|
| HTH_ICLR |
smart00346 |
helix_turn_helix isocitrate lyase regulation; |
17-64 |
5.67e-04 |
|
helix_turn_helix isocitrate lyase regulation;
Pssm-ID: 214629 [Multi-domain] Cd Length: 91 Bit Score: 38.72 E-value: 5.67e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 2570555858 17 VLNTI-RKKGNVSRADIAHITGLNKSTVSFLVDELINEGFVREEGPGES 64
Cdd:smart00346 10 VLRALaEEPGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQDGQNGR 58
|
|
| HTH_CRP |
cd00092 |
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ... |
27-73 |
2.65e-03 |
|
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.
Pssm-ID: 238044 [Multi-domain] Cd Length: 67 Bit Score: 36.10 E-value: 2.65e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 2570555858 27 VSRADIAHITGLNKSTVSFLVDELINEGFVreegpgeSKGGRKPIIL 73
Cdd:cd00092 26 LTRQEIADYLGLTRETVSRTLKELEEEGLI-------SRRGRGKYRV 65
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ASKHA_ATPase_ROK_BsXylR-like |
cd24076 |
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ... |
80-392 |
1.48e-103 |
|
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.
Pssm-ID: 466926 [Multi-domain] Cd Length: 303 Bit Score: 308.34 E-value: 1.48e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 80 GCIIGIDLDVKYILIVLTDLMANVIWEKKVDVKIGESQQAIIERLIELIDKAILNAPETIRGILGIGIGVPGIVDYKKGT 159
Cdd:cd24076 1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLPASDDPDEVLAQLAALIREALAAAPDSPLGILGIGVGVPGLVDSEDGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 160 VLMAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLAGE 239
Cdd:cd24076 81 VLLAPNLGWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGFAGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 240 MGHMTINILDHQCSCGNTGCWENYASEKALFDYIHTQLIMGksdnyinkdnfNTLSALDIINYAQKGSEIAVEALKEIGR 319
Cdd:cd24076 161 IGHMTVDPDGPPCSCGNRGCWETYASERALLRAAGRLGAGG-----------EPLSLAELVEAARAGDPAALAALEEVGE 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2570555858 320 KLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKKCLVYRYHKVKIKTSKLQFHAGAIGAVSLVIS 392
Cdd:cd24076 230 YLGIGLANLVNTFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVVSRLGEDAAALGAAALAID 302
|
|
| NagC |
COG1940 |
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ... |
76-392 |
1.24e-73 |
|
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];
Pssm-ID: 441543 [Multi-domain] Cd Length: 306 Bit Score: 232.09 E-value: 1.24e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 76 NNKAGCIIGIDLDVKYILIVLTDLMANVIWEKKVDVKIGESQQAIIERLIELIDKAILNAPETIRGILGIGIGVPGIVDY 155
Cdd:COG1940 1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 156 KKGTVLMAPNLK-WENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSagigigtgiiingELYRGTV 234
Cdd:COG1940 81 ETGVVLNAPNLPgWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTlgtgigggivingKLLRGAN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 235 GLAGEMGHMTINILDHQCSCGNTGCWENYASEKALFDYIHTQLIMGKsdnyinkdnfntLSALDIINYAQKGSEIAVEAL 314
Cdd:COG1940 161 GNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELGGAEK------------LTAEELFAAARAGDPLALEVL 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2570555858 315 KEIGRKLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKKCLVYRYHKVKIKTSKLQFHAGAIGAVSLVIS 392
Cdd:COG1940 229 DEAARYLGIGLANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLGDDAGLLGAAALALE 306
|
|
| ASKHA_NBD_ROK_TM1224-like |
cd24059 |
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ... |
81-396 |
4.21e-70 |
|
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.
Pssm-ID: 466909 [Multi-domain] Cd Length: 305 Bit Score: 222.85 E-value: 4.21e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 81 CIIGIDLDVKYILIVLTDLMANVIWEKKVDVKIGESQQAIIERLIELIDKAILNAPEtIRGILGIGIGVPGIVDYKKGTV 160
Cdd:cd24059 2 YVIGVEIGRDLLSAVLCDLSGNILAREKYPLDEKENPEEVLEKLYELIDRLLEKENI-KSKILGIGIGAPGPLDVEKGII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 161 LMAPNLK-WENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLAGE 239
Cdd:cd24059 81 LNPPNFPgWENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 240 MGHMTINILDHQCSCGNTGCWENYASEKALFDYIHTQLimgksdnyinkdNFNTLSALDIINYAQKGSEIAVEALKEIGR 319
Cdd:cd24059 161 IGHTSIDINGPRCSCGNRGCLELYASIPAIEKKARSAL------------GSGRSFQLDIVEALQKGDPIADEVIEEAAK 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2570555858 320 KLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKKCLVYRYHKVKIKTSKLQFHAGAIGAVSLVISELFA 396
Cdd:cd24059 229 YLGIGLVNLINLLNPEAIIIGGELIYLGERYLEPIEKEVNSRLFGRNAREVRILKSSLGEDAPLLGAAALVLNKYFE 305
|
|
| ASKHA_ATPase_ROK_Lmo0178-like |
cd24071 |
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ... |
80-395 |
8.15e-58 |
|
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466921 [Multi-domain] Cd Length: 312 Bit Score: 191.34 E-value: 8.15e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 80 GCIIGIDLDVKYILIVLTDLMANVIWEKKVDVKIGESQQAIIERLIELIDKAILNAPeTIRGILGIGIGVPGIVDYKKGT 159
Cdd:cd24071 1 GYIIGVKIEEGYLVLALTDLKGKILEKTRIPFDHETDPEKVIELIAENIKKLIKNKH-VEKKLLGIGIAVSGLVDSKKGI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 160 VLMAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLAGE 239
Cdd:cd24071 80 VIRSTILGWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGAGE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 240 MGHMTINILDHQCSCGNTGCWENYASEKALFDYIHTQLIMGKSDNYinkDNFNTLSALDIINYAQKGSEIAVEALKEIGR 319
Cdd:cd24071 160 IGHMTIQPDGRKCYCGQKGCLEAYASFEALVNEIKELTESYPLSLL---KELEDFEIEKVREAAEEGDSVATELFKKAGE 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2570555858 320 KLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKKCLVYRYHKVKIKTSKLQFHAGAIGAVSLVISELF 395
Cdd:cd24071 237 YLGIGIKNLINIFNPEAIIIGGEGLEFKDYFLPKIIEIAKENFFGKAGRNVIILVDSLGEDAWVLGAALLVIDHLF 312
|
|
| ROK |
pfam00480 |
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ... |
83-391 |
1.13e-53 |
|
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.
Pssm-ID: 395384 [Multi-domain] Cd Length: 292 Bit Score: 179.84 E-value: 1.13e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 83 IGIDLDVKYILIVLTDLMANVIWekkvDVKIGESQQAIIERLIELIDKAILNAPETIRGILGIGIGVPGIVDYKKGTVLM 162
Cdd:pfam00480 1 IGIDIGGTKIAAALFDEEGEILA----RERVPTPTTTTEETLVDAIAFFVDSAQRKFGELIAVGIGSPGLISPKYGYITN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 163 APNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLAGEMGH 242
Cdd:pfam00480 77 TPNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGH 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 243 MTINILDHQCSCGNTGCWENYASEKALFDYIHTQLimgksdnyinkdnfNTLSALDIINYAQKGSEIAVEALKEIGRKLG 322
Cdd:pfam00480 157 IQLDPNGPKCGCGNHGCLETIASGRALEKRYQQKG--------------EDLEGKDIIVLAEQGDEVAEEAVERLARYLA 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2570555858 323 VGIVNVINTFNPELVIIGNTLSLARGLiLDEILKEVEKkcLVYRYHK---VKIKTSKLQFHAGAIGAVSLVI 391
Cdd:pfam00480 223 KAIANLINLFDPQAIVLGGGVSNADGL-LEAIRSLVKK--YLNGYLPvppVIIVAASLGDNAGALGAAALAK 291
|
|
| ASKHA_ATPase_ROK_CYANR |
cd24073 |
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ... |
80-395 |
1.29e-53 |
|
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466923 [Multi-domain] Cd Length: 304 Bit Score: 180.06 E-value: 1.29e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 80 GCIIGIDLDVKYILIVLTDLMANVIWEKKVDVKIGESQQaIIERLIELIDKAILNAPETIRGILGIGIGVPGIVDYKKGT 159
Cdd:cd24073 1 AYVVGVKLTEDRITAVLTDLRGNVLASHTLPLDSGDPEA-VAEAIAEAVAELLAQAGLSPDRLLGIGVGLPGLVDAETGI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 160 VLMAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLAGE 239
Cdd:cd24073 80 CRWSPLLGWRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAGE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 240 MGHMTINILDHQCSCGNTGCWENYASEKALFDYIHTQLIMGKSdnyinkdnfntLSALDIINYAQKGSEIAVEALKEIGR 319
Cdd:cd24073 160 IGHTTVDPDGPPCRCGKRGCLEAYASDPAILRQAREAGLRGEP-----------LTIEDLLAAARAGDPAARAILRRAGR 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2570555858 320 KLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKKCLVYRYHKVKIKTSKLQFHAGAIGAVSLVISELF 395
Cdd:cd24073 229 ALGLALANLVNLLDPELIIISGEGVRAGDLLFEPMREALRAHVFPGLASDLELVIHPWGDEAWARGAAALALQEFF 304
|
|
| ASKHA_ATPase_ROK_SaXylR-like |
cd24077 |
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ... |
80-392 |
1.34e-52 |
|
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.
Pssm-ID: 466927 [Multi-domain] Cd Length: 295 Bit Score: 176.96 E-value: 1.34e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 80 GCIIGIDLDVKYILIVLTDLMANVIWEKKVDVKIgESQQAIIERLIELIDKAILNAPETIRGILGIGIGVPGIVDykKGT 159
Cdd:cd24077 1 GYSIGIDLGYNYISLMLTYLDGEIISSKQIKLLD-ISFENILEILKSIIQELISQAPKTPYGLVGIGIGIHGIVD--ENE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 160 VLMAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGagIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLAGE 239
Cdd:cd24077 78 IIFTPYYDLEDIDLKEKLEEKFNVPVYLENEANLSALAERTFS--EDYDNLISISIHSGIGAGIIINNQLYRGYNGFAGE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 240 MGHMTINILDHQCSCGNTGCWENYASEKALFdyihtqlimgksDNYINKDNFNTLSALDIINYAQKGSEIAVEALKEIGR 319
Cdd:cd24077 156 IGHMIIVPNGKPCPCGNKGCLEQYASEKALL------------KELSEKKGLETLTFDDLIQLYNEGDPEALELIDQFIK 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2570555858 320 KLGVGIVNVINTFNPELVIIGNTLSlargLILDEILKEVEKKCLVYRYHKVKIKTSKLQFHAGAIGAVSLVIS 392
Cdd:cd24077 224 YLAIGINNIINTFNPEIIIINSSLI----NEIPELLEKIKEQLSSSFNKYVEILISTLGKNATLLGGAAVAIK 292
|
|
| ASKHA_ATPase_ROK |
cd23763 |
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ... |
83-389 |
3.49e-49 |
|
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.
Pssm-ID: 466849 [Multi-domain] Cd Length: 239 Bit Score: 166.48 E-value: 3.49e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 83 IGIDLDVKYILIVLTDLMANVIWEKKVDVKIGESQQAIIERLIELIDKAILNAPetirgilgiGIGVPG--------IVD 154
Cdd:cd23763 1 IGIDIGGTKIRAALVDLDGEILARERVPTPAEEGPEAVLDRIAELIEELLAEAG---------VRERILgigigvpgPVD 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 155 YKKGTVLMAPNLK-WENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAgigigtgiiingELYRGT 233
Cdd:cd23763 72 PETGIVLFAPNLPwWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLgtgigggiiidgKLYRGA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 234 VGLAGEMGHMTInildhqcscgntgcwenyasekalfdyihtqlimgksdnyinkdnfntlsaldiinyaqkgseiavea 313
Cdd:cd23763 152 NGAAGEIGHITV-------------------------------------------------------------------- 163
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2570555858 314 LKEIGRKLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKKCLVYRYHKVKIKTSKLQFHAGAIGAVSL 389
Cdd:cd23763 164 LEEAARYLGIGLANLINLLNPELIVLGGGVAEAGDLLLEPIREAVRRRALPPLRRRVRIVPSELGDDAGLLGAAAL 239
|
|
| ASKHA_NBD_ROK_FnNanK-like |
cd24068 |
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ... |
81-389 |
5.40e-46 |
|
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466918 [Multi-domain] Cd Length: 294 Bit Score: 159.65 E-value: 5.40e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 81 CIIGIDL---DVKYILIvltDLMANVIWEKKVDVKIGESQQAIIERLIELIDKAIlnapeTIRGILGIGIGVPGIVDYKK 157
Cdd:cd24068 1 KILGIDIggtKIKYGLV---DADGEILEKDSVPTPASKGGDAILERLLEIIAELK-----EKYDIEGIGISSAGQVDPKT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 158 GTVLMA-PNLK-WENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVG 235
Cdd:cd24068 73 GEVIYAtDNLPgWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 236 LAGEMGHMTINILDHQCSCGNTGCWENYASEKALFDYIHTQLimgksdnyinkdNFNTLSALDIINYAQKGSEIAVEALK 315
Cdd:cd24068 153 SAGELGHMVVDPGGRPCCCGGKGCLEQYASGTALVRRVAEAL------------GEPGIDGREIFDLADAGDPLAKEVVE 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2570555858 316 EIGRKLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKKCLVYRYHKVKIKTSKLQFHAGAIGAVSL 389
Cdd:cd24068 221 EFAEDLATGLANLVHIFDPEVIVIGGGISAQGELFLEELREELRKLLMPPLLDATKIEPAKLGNDAGLLGAAYL 294
|
|
| ASKHA_NBD_ROK_SgGLK-like |
cd24061 |
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ... |
153-389 |
1.47e-40 |
|
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466911 [Multi-domain] Cd Length: 306 Bit Score: 145.96 E-value: 1.47e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 153 VDYKKGTVLMAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRG 232
Cdd:cd24061 65 VDADRATVLFAPNIAWRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGGGIVIGGKLLRG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 233 TVGLAGEMGHMTINILDHQCSCGNTGCWENYASEKALFDYihTQLIMGK----SDNYINKDNFNTLSALDIINYAQKGSE 308
Cdd:cd24061 145 AFGIAGEFGHIRVVPDGLLCGCGSRGCWEQYASGRALVRY--AKEAANAtpegAAVLLADGSVDGITGKHISEAARAGDP 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 309 IAVEALKEIGRKLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKKCLVYRYHKV-KIKTSKLQFHAGAIGAV 387
Cdd:cd24061 223 VALDALRELARWLGAGLASLAALLDPELFVIGGGVSDAGDLLLDPIREAFERWLPGRGWRPIpRLRTAQLGNDAGLIGAA 302
|
..
gi 2570555858 388 SL 389
Cdd:cd24061 303 DL 304
|
|
| ASKHA_NBD_ROK_BsGLK-like |
cd24062 |
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ... |
82-389 |
6.60e-40 |
|
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466912 [Multi-domain] Cd Length: 311 Bit Score: 144.35 E-value: 6.60e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 82 IIGIDLDVKYILIVLTDLMANVIWEKKVDVKIGESQQAIIERLIELIDKAILNAPETIRGILGIGIGVPGIVDYKKGTVL 161
Cdd:cd24062 2 IVGIDVGGTTIKMAFLTQEGEIVQKWEIPTNKLEGGENIITDIAESIQQLLEELGYSKEDLIGIGVGVPGPVDVETGTVE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 162 MAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLAGEMG 241
Cdd:cd24062 82 VAVNLGWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVFITLGTGVGGGVIANGKIVHGANGAAGEIG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 242 HMTINILDH-QCSCGNTGCWENYASEKALFDYIHTQLIMGKSD---NYINKDnfNTLSALDIINYAQKGSEIAVEALKEI 317
Cdd:cd24062 162 HITVNPEGGaPCNCGKTGCLETVASATGIVRIAREELEEGKGSsalRILALG--GELTAKDVFEAAKAGDELALAVVDTV 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2570555858 318 GRKLGVGIVNVINTFNPELVIIGNTLSLArGLILDEILKEVEKKCLVYRYHK-VKIKTSKLQFHAGAIGAVSL 389
Cdd:cd24062 240 ARYLGLALANLANTLNPEKIVIGGGVSAA-GEFLLSPVKEYFDRFTFPRVRQdTEIVLATLGNDAGVIGAAWL 311
|
|
| ASKHA_NBD_ROK_ApGLK-like |
cd24063 |
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ... |
153-389 |
6.94e-40 |
|
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466913 [Multi-domain] Cd Length: 308 Bit Score: 144.02 E-value: 6.94e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 153 VDYKKGTVLMAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRG 232
Cdd:cd24063 71 LDLRKGTIVNSPNIKGKEIPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGIGGGVIVDGRLLLG 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 233 TVGLAGEMGHMTINILDH-QCSCGNTGCWENYASEKAL--FDYIHTQLIMGKSDNYINKDNFNTLSALDIINYAQKGSEI 309
Cdd:cd24063 151 KNGNAAEVGHLVVDTESGlKCGCGGYGHWEAFASGRGIprFAREWAEGFSSRTSLKLRNPGGEGITAKEVFSAARKGDPL 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 310 AVEALKEIGRKLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKKCLVYRyhKVKIKTSKLQFHAGAIGAVSL 389
Cdd:cd24063 231 ALKIIEKLARYNGRGIANVINAYDPELIVIGGSVFNNNKDILDPLIEYLEKNPAISK--GPEIVLSELGDDVGLIGALAL 308
|
|
| ROK_glcA_fam |
TIGR00744 |
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ... |
153-393 |
4.01e-37 |
|
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]
Pssm-ID: 273246 [Multi-domain] Cd Length: 318 Bit Score: 136.95 E-value: 4.01e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 153 VDYKKGTVLMAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRG 232
Cdd:TIGR00744 69 VNRQRGTVYFAVNLDWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHG 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 233 TVGLAGEMGHMTInilDHQ----CSCGNTGCWENYASEKALFDYI---HTQLIMGKSDNYINKDnfNTLSALDIINYAQK 305
Cdd:TIGR00744 149 HNGVGAEIGHIRM---VPDgrllCNCGKQGCIETYASATGLVRYAkraNAKPERAEVLLALGDG--DGISAKHVFVAARQ 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 306 GSEIAVEALKEIGRKLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVeKKCLVYRYHKV-KIKTSKLQFHAGAI 384
Cdd:TIGR00744 224 GDPVAVDSYREVARWAGAGLADLASLFNPSAIVLGGGLSDAGDLLLDPIRKSY-KRWLFGGARQVaDIIAAQLGNDAGLV 302
|
....*....
gi 2570555858 385 GAVSLVISE 393
Cdd:TIGR00744 303 GAADLARTY 311
|
|
| ASKHA_ATPase_ROK_YphH-like |
cd24072 |
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ... |
80-356 |
1.11e-36 |
|
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466922 [Multi-domain] Cd Length: 308 Bit Score: 135.62 E-value: 1.11e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 80 GCIIGIDLDVKYILIVLTDLMANVIWEKKVDVKIGESQQAIIERLIELIDKAILNAPETIRGILGIGIGVpgiVDYKKGT 159
Cdd:cd24072 1 AWVLGIVVSPNSLRAQVGNACGELLGEFEYRVITLETPEALIDEIIDCIDRLLKLWKDRVKGIALAIQGL---VDSHKGV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 160 VLMAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLAGE 239
Cdd:cd24072 78 SLWSPGAPWRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGIGSAIVIDNKLYIGASSGSGE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 240 MGHMTINILDHQCSCGNTGCWENYASEKALFDYIHTQLIMGKSDNYINKdnfntLSALDIINYAQKGSEIAVEALKEIGR 319
Cdd:cd24072 158 IGHTKVNPDGARCDCGRRGCLETVASNSALKRNARVTLKLGPVSADPEK-----LTMEQLIEALEEGEPIATQIFDRAAN 232
|
250 260 270
....*....|....*....|....*....|....*..
gi 2570555858 320 KLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILK 356
Cdd:cd24072 233 AIGRSLANILNLLNPEQVLLYGRGCRAGDLLLPAIRR 269
|
|
| ASKHA_ATPase_ROK_NagC |
cd24075 |
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ... |
82-390 |
4.68e-36 |
|
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466925 [Multi-domain] Cd Length: 315 Bit Score: 134.03 E-value: 4.68e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 82 IIGIDLDVKYILIVLTDLMANVIWEKKVDVKiGESQQAIIERLIELIDKAILNAPETIRGILGIGIGVPGIVDYKKGTVL 161
Cdd:cd24075 3 ILAVRLGRHDLTLGLYDLSGELLAEHTVPLT-ALNQEALLSQLIEEIAQFLKSHRRKTQRLIAISITLPGLINPKTGVVH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 162 MAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLAGEMG 241
Cdd:cd24075 82 YMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEIG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 242 HMTINILDHQCSCGNTGCWENYASEKALFDYIHTQLIMGksdnYINKDNFNTLSALDIINYAQKGSEIAVEALKEIGRKL 321
Cdd:cd24075 162 HIQIEPLGERCHCGNFGCLETVASNAAIEQRVKKLLKQG----YASQLTLQDCTIKDICQAALNGDQLAQDVIKRAGRYL 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2570555858 322 GVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKKCLVYRYHKVKIKTSKLQfHAGAIGAVSLV 390
Cdd:cd24075 238 GKVIAILINLLNPQKIIIAGEITQADKVLLPVIKKCIQSQALPDFRQELKIVASQLD-HNSAIGAFALV 305
|
|
| ASKHA_NBD_ROK_TmGLK-like |
cd24064 |
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ... |
82-389 |
4.45e-35 |
|
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466914 [Multi-domain] Cd Length: 301 Bit Score: 131.08 E-value: 4.45e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 82 IIGIDLDVKYILIVLTDLMANVIWEKKVDVKIGESQQAIIERLIELIDKAILNapetiRGILGIGIGVPGIVDYKKGTVL 161
Cdd:cd24064 1 VIGIDLGGTDTKIGIVDENGDILKKKTIDTKVENGKEDVINRIAETVNELIEE-----MELLGIGIGSPGSIDRENGIVR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 162 MAPNL-KWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLAGEM 240
Cdd:cd24064 76 FSPNFpDWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTGVGSGVICHGQLLTGYDGIAAEL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 241 GHMTINILDHQCSCGNTGCWENYASEKALFDYIHTQLIMGKSDNYINKDNFNtlsALDIINYAQKGSEIAVEALKEIGRK 320
Cdd:cd24064 156 GHVIVEPNGPICGCGNRGCVEAFASATAIIRYARESRKRYPDSLAGESEKIN---AKHVFDAARKNDPLATMVFRRVVDA 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2570555858 321 LGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKKCLVYRYHKVKIKTSKLQFHAGAIGAVSL 389
Cdd:cd24064 233 LAIAIGGFVHIFNPEIIIIGGGISRAGSFLLDPIREKTKKYVMLSFQDTYSIELSNLVEDAGILGAASI 301
|
|
| ASKHA_NBD_ROK_TtHK-like |
cd24065 |
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ... |
153-389 |
1.25e-28 |
|
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466915 [Multi-domain] Cd Length: 289 Bit Score: 113.19 E-value: 1.25e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 153 VDYKKGTVLMAPNLK-WENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYR 231
Cdd:cd24065 67 LDFRRGRVRFAPNIPgLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYVTISTGIGGGLVLGGRVLR 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 232 GTVGLAGEMGHMTINILDHQCSCGNTGCWENYASEKAL-----FDYihtqlimgksdnyiNKDnfntLSALDIINYAQKG 306
Cdd:cd24065 147 GRHGQAGEIGHTTVLPGGPMCGCGLVGCLEALASGRALardasFAY--------------GRP----MSTAELFELAQQG 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 307 SEIAVEALKEIGRKLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKKClvYRYHKVKIKTSKLQFHAGAIGA 386
Cdd:cd24065 209 EPKALRIVEQAAAHLGIGLANLQKALDPEVFVLGGGVAQVGDYYLLPVQEAARRYT--EGWHAPPLRLAHLGTDAGVIGA 286
|
...
gi 2570555858 387 VSL 389
Cdd:cd24065 287 ALA 289
|
|
| ASKHA_NBD_ROK_GNE |
cd24060 |
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ... |
153-344 |
1.31e-28 |
|
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.
Pssm-ID: 466910 [Multi-domain] Cd Length: 305 Bit Score: 113.67 E-value: 1.31e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 153 VDYKKGTVLMAPNL--KWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELY 230
Cdd:cd24060 71 VNPREGIVLHSTKLiqEWSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTGIGGGIILNHELI 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 231 RGTVGLAGEMGHMTINILDHQCSCGNTGCWENYASEKAL---FDYIHTQ---LIMGKSdnyINKDnfNTLSALDIINYAQ 304
Cdd:cd24060 151 HGSSFCAAELGHIVVSLDGPDCMCGSHGCVEAYASGMALqreAKKLHDEdllLVEGMS---VTND--EEVTAKHLIQAAK 225
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 2570555858 305 KGSEIAVEALKEIGRKLGVGIVNVINTFNPELVIIGNTLS 344
Cdd:cd24060 226 LGNAKAQKILRTAGTALGLGIVNILHTLNPSLVILSGVLA 265
|
|
| ASKHA_ATPase_ROK_Mlc |
cd24074 |
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ... |
85-395 |
3.76e-22 |
|
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466924 [Multi-domain] Cd Length: 322 Bit Score: 95.84 E-value: 3.76e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 85 IDLDVKYILIVLTDLMANVIWEKKVDVKIgESQQAIIERLIELIDKAILNAPETIRGILGIGIGVPGIVDYKKGTVLMAP 164
Cdd:cd24074 7 IRIGRGYITLALRDLNGRLLAEERYPLPA-KDNDPFLDRLLESISEFFSRHQKKLERLTAIAITLPGIIDPESGIVHRLP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 165 NLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLAGEMGHMT 244
Cdd:cd24074 86 FYDIKNLPLGEALEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRLGELGHTQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 245 INILDHQCSCGNTGCWENYASEKALFDYIhTQLIMGKSDNYINKdnfNTLSALDIINYAQKGSEIAVEALKEIGRKLGVG 324
Cdd:cd24074 166 IDPYGKRCYCGNHGCLETVASIPAILEQA-NQLLEQSPDSMLHG---QPISIESLCQAALAGDPLAQDIIIQVGRHLGRI 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2570555858 325 IVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKKCLVYRYHKVKIKTSKLqFHAGAIGAVSLVISELF 395
Cdd:cd24074 242 LAILVNLFNPEKILIGSPLNNAAEILFPALSQSIRQQSLPAYSQHLQIESTKF-YNDGTMPGAALIKDALY 311
|
|
| ASKHA_NBD_ROK_AlsK |
cd24070 |
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ... |
81-390 |
6.23e-22 |
|
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466920 [Multi-domain] Cd Length: 293 Bit Score: 94.92 E-value: 6.23e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 81 CIIGIDLDVKYILIVLTDLMANVIWEKKVDVKIGESQQAIIERLIELIDKAILNA-----------PETirgilgigigv 149
Cdd:cd24070 2 YVLGIDIGGTNIRIGLVDEDGKLLDFEKVPSKDLLRAGDPVEVLADLIREYIEEAglkpaaivigvPGT----------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 150 pgiVDYKKGTVLMAPNLK-WENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNL--VYV-----SAGIGIGt 221
Cdd:cd24070 71 ---VDKDRRTVISTPNIPgLDGVNLADILENKLGIPVILERDVNLLLLYDMRAGNLDDEGVVlgFYIgtgigNAILING- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 222 giiingELYRGTVGLAGEMGHMTINILDHQCSCGNTGCWENYASEKALfdyihtqlimgksdNYINKDNFNTLSALDIIN 301
Cdd:cd24070 147 ------KPLRGKNGVAGELGHIPVYGNGKPCGCGNTGCLETYASGRAL--------------EEIAEEHYPDTPILDIFV 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 302 YAQkgseiAVEALKEIGRKLGVGIVNVINTFNPELVIIGNTLSLARGLILDEILKEVEKK-CLVYRYHKVKIKTSKLQFH 380
Cdd:cd24070 207 DHG-----DEPELDEFVEDLALAIATEINILDPDAVILGGGVIDMKGFPRETLEEYIRKHlRKPYPADNLKIIYAELGPE 281
|
330
....*....|
gi 2570555858 381 AGAIGAVSLV 390
Cdd:cd24070 282 AGVIGAAIYA 291
|
|
| ASKHA_NBD_ROK-like |
cd24152 |
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ... |
153-389 |
1.48e-17 |
|
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466988 [Multi-domain] Cd Length: 286 Bit Score: 82.23 E-value: 1.48e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 153 VDYKKGTVL-MAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYR 231
Cdd:cd24152 65 IDPETGIIYgGGALPYLKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYR 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 232 GTVGLAGEMGHMTINILDHQ-----CSCGNTGCWENYASEKALfdyihtqlimgksdnyinkdnfNTLSALDIINYAQKG 306
Cdd:cd24152 145 GSHFFAGEFSYLLTDDDDKDllffsGLASMFGLVKRYNKAKGL----------------------EPLDGEEIFEKYAKG 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 307 SEIAVEALKEIGRKLGVGIVNVINTFNPELVIIGNTLSLARgLILDEILKEVEKKCLVYRYHKVKIKTSKLQFHAGA--I 384
Cdd:cd24152 203 DEAAKKILDEYIRNLAKLIYNIQYILDPEVIVIGGGISEQP-LFIEDLKKEVNEILANRPGSIPKPEIKACKFGNDAnlL 281
|
....*
gi 2570555858 385 GAVSL 389
Cdd:cd24152 282 GALYN 286
|
|
| ASKHA_NBD_ROK_NAGK |
cd24057 |
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ... |
153-386 |
1.80e-14 |
|
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466907 [Multi-domain] Cd Length: 298 Bit Score: 73.42 E-value: 1.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 153 VDYKKGTVLMA--PNLKweNVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNN-------------LVYvsagi 217
Cdd:cd24057 68 IDPEDGTLITAniPAAK--GRPLRADLSARLGRPVRIDNDANCFALSEAWDGAGRGYPSvfglilgtgvgggLVV----- 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 218 gigtgiiiNGELYRGTVGLAGEMGHMTI---------NILDHQCSCGNTGCWENYASEKA---LFDYIHTQlimgksdny 285
Cdd:cd24057 141 --------NGRLVGGRSGIAGEWGHGPLpadalllgyDLPVLRCGCGQTGCLETYLSGRGlerLYAHLYGE--------- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 286 inkdnfnTLSALDIINYAQKGSEIAVEALKEIGRKLGVGIVNVINTFNPELVIIGNTLSLARGLIlDEILKEVEKKcLVY 365
Cdd:cd24057 204 -------ELDAPEIIAAWAAGDPQAVAHVDRWLDLLAGCLANILTALDPDVVVLGGGLSNFPALI-AELPAALPAH-LLS 274
|
250 260
....*....|....*....|.
gi 2570555858 366 RYHKVKIKTSKLQFHAGAIGA 386
Cdd:cd24057 275 GARTPRIVPARHGDAGGVRGA 295
|
|
| PRK13310 |
PRK13310 |
N-acetyl-D-glucosamine kinase; Provisional |
153-344 |
4.81e-14 |
|
N-acetyl-D-glucosamine kinase; Provisional
Pssm-ID: 183967 [Multi-domain] Cd Length: 303 Bit Score: 72.33 E-value: 4.81e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 153 VDYKKGTVLMAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKW------------------FGAGIKYNNLVYvs 214
Cdd:PRK13310 68 PETEDGTLYAANVPAASGKPLRADLSARLGRDVRLDNDANCFALSEAWddeftqyplvmglilgtgVGGGLVFNGKPI-- 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 215 agigigtgiiingelyRGTVGLAGEMGHMTINI--LDH--------QCSCGNTGCWENYASEKAlFDYIHTQLimgksdn 284
Cdd:PRK13310 146 ----------------SGRSYITGEFGHMRLPVdaLTLlgwdaplrRCGCGQKGCIENYLSGRG-FEWLYQHY------- 201
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 285 yinkdNFNTLSALDIINYAQKGSEIAVEALKEIGRKLGVGIVNVINTFNPELVIIGNTLS 344
Cdd:PRK13310 202 -----YGEPLQAPEIIALYYQGDEQAVAHVERYLDLLAICLGNILTIVDPHLVVLGGGLS 256
|
|
| ASKHA_NBD_ROK_EcNanK-like |
cd24069 |
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ... |
168-389 |
1.46e-13 |
|
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466919 [Multi-domain] Cd Length: 283 Bit Score: 70.39 E-value: 1.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 168 WENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLAGEMGHMTINI 247
Cdd:cd24069 79 LSGFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFITVSTGVGGGLVLNGQLLTGPNGLAGHIGHTLADP 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 248 LDHQCSCGNTGCWENYASEKALFDYihTQLIMGKsdnyinkdnfnTLSALDIINYAQKGSEIAVEALKEIGRKLGVGIVN 327
Cdd:cd24069 159 PGPVCGCGRRGCVEAIASGTAIAAA--ASEILGE-----------PVDAKDVFERARSGDEEAARLIDRAARALADLIAD 225
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2570555858 328 VINTFNPELVIIGNTLSLARGLIlDEILKEVEKKCLVYRyhkVKIKTSKLQFHAGAIGAVSL 389
Cdd:cd24069 226 LKATLDLDCVVIGGSVGLAEGFL-ERVEQYLADEPAIFR---VSLEPARLGQDAGLLGAALL 283
|
|
| PRK09698 |
PRK09698 |
D-allose kinase; Provisional |
81-396 |
2.49e-12 |
|
D-allose kinase; Provisional
Pssm-ID: 182034 [Multi-domain] Cd Length: 302 Bit Score: 66.93 E-value: 2.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 81 CIIGIDLDVKYILIVLTDLMANVI-WEKKVDVKIgeSQQAIIERLIELIDKAILnapETIRGILGIGIGVPGIVDYKKGT 159
Cdd:PRK09698 5 VVLGIDMGGTHIRFCLVDAEGEILhCEKKRTAEV--IAPDLVSGLGEMIDEYLR---RFNARCHGIVMGFPALVSKDRRT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 160 VLMAPNLKW---ENVPLKQIIENKFKIKVQIDNEAN-----------------VGAigekWFGAGIkyNNLVYVSAGigi 219
Cdd:PRK09698 80 VISTPNLPLtalDLYDLADKLENTLNCPVFFSRDVNlqllwdvkennltqqlvLGA----YLGTGM--GFAVWMNGA--- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 220 gtgiiingeLYRGTVGLAGEMGHMTINILDHQCSCGNTGCWENYASEKALfDYIHTQlimgKSDNYinkdnfnTLSALdi 299
Cdd:PRK09698 151 ---------PWTGAHGVAGELGHIPLGDMTQHCGCGNPGCLETNCSGMAL-RRWYEQ----QPRDY-------PLSDL-- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 300 inYAQKGSEIAVEALKEigrKLGVGIVNVINTFNPELVIIGntlslarGLILD------EILKEVEKKCLV--YRYHKVK 371
Cdd:PRK09698 208 --FVHAGDHPFIQSLLE---NLARAIATSINLFDPDAIILG-------GGVMDmpafprETLIAMIQKYLRkpLPYEVVR 275
|
330 340
....*....|....*....|....*
gi 2570555858 372 IKTSKLQFHAGAIGAVSLVISELFA 396
Cdd:PRK09698 276 FIYASSSDFNGAQGAAILAHQRFLP 300
|
|
| ASKHA_NBD_ROK_EcFRK-like |
cd24066 |
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ... |
172-344 |
3.33e-12 |
|
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466916 [Multi-domain] Cd Length: 294 Bit Score: 66.46 E-value: 3.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 172 PLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNN-------------LVYvsagigigtgiiiNGELYRGTVGLAG 238
Cdd:cd24066 86 PLKADLEARLGRPVRIENDANCFALSEATDGAGAGAGVvfgvilgtgvgggIVV-------------NGRVLTGANGIAG 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 239 EMGHMTINILDH------QCSCGNTGCWENYASEKALFDYiHTQLImGKsdnyinkdnfnTLSALDIINYAQKGSEIAVE 312
Cdd:cd24066 153 EWGHNPLPWPDEdelpgpPCYCGKRGCVETFLSGPALERD-YARLT-GK-----------TLSAEEIVALARAGDAAAVA 219
|
170 180 190
....*....|....*....|....*....|..
gi 2570555858 313 ALKEIGRKLGVGIVNVINTFNPELVIIGNTLS 344
Cdd:cd24066 220 TLDRFLDRLGRALANVINILDPDVIVLGGGLS 251
|
|
| ASKHA_NBD_ROK_BsFRK-like |
cd24067 |
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ... |
158-389 |
1.45e-07 |
|
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466917 [Multi-domain] Cd Length: 285 Bit Score: 52.55 E-value: 1.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 158 GTVLMAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTvgLA 237
Cdd:cd24067 72 GYITTTPKPGWRNFDILGALKRAFPVPVGFDTDVNAAALAEYRWGAAKGLDSLAYITVGTGIGVGLVVNGKPVHGL--LH 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 238 GEMGHMTINIL----DHQCSC---GNtgCWENYASEKALFDyihtqlimgksdnyinkdnfntlsaldiiNYAQKGSEIA 310
Cdd:cd24067 150 PEMGHIRVPRHpdddGFPGVCpfhGD--CLEGLASGPAIAA-----------------------------RWGIPAEELP 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 311 V--EALKEIGRKLGVGIVNVINTFNPELVIIGNTLSLARGLiLDEILKEVEKkcLVYRYHKVK---------IKTSKLQF 379
Cdd:cd24067 199 DdhPAWDLEAYYLAQACANLTLTLSPERIVLGGGVMQRPGL-FPRIREKFRK--LLNGYLEVPrllpdideyIVPPALGN 275
|
250
....*....|
gi 2570555858 380 HAGAIGAVSL 389
Cdd:cd24067 276 DAGILGALAL 285
|
|
| COG3398 |
COG3398 |
Predicted transcriptional regulator, contains two HTH domains [Transcription]; |
14-79 |
1.56e-05 |
|
Predicted transcriptional regulator, contains two HTH domains [Transcription];
Pssm-ID: 442625 [Multi-domain] Cd Length: 159 Bit Score: 44.87 E-value: 1.56e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2570555858 14 KSIVLnTIRKKGNVSRADIAHITGLNKSTVSFLVDELINEGFVREEgpgesKGGRKpIILSINNKA 79
Cdd:COG3398 100 RRILL-YLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERE-----RDGRN-VRYYLNPPE 158
|
|
| PRK13311 |
PRK13311 |
N-acetyl-D-glucosamine kinase; Provisional |
158-329 |
2.76e-05 |
|
N-acetyl-D-glucosamine kinase; Provisional
Pssm-ID: 106271 [Multi-domain] Cd Length: 256 Bit Score: 45.41 E-value: 2.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 158 GTVLMAPNLKWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLA 237
Cdd:PRK13311 73 GTVFTANVPSAMGQPLQADLSRLIQREVRIDNDANCFALSEAWDPEFRTYPTVLGLILGTGVGGGLIVNGSIVSGRNHIT 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 238 GEMGH--MTINILD--------HQCSCGNTGCWENYASEKAlFDYIHTQLIMgksdnyinkdnfNTLSALDIINYAQKGS 307
Cdd:PRK13311 153 GEFGHfrLPVDALDilgadiprVPCGCGHRGCIENYISGRG-FEWMYSHFYQ------------HTLPATDIIAHYAAGE 219
|
170 180
....*....|....*....|..
gi 2570555858 308 EIAVEALKEIGRKLGVGIVNVI 329
Cdd:PRK13311 220 PKAVAHVERFMDVLAVCLGNLL 241
|
|
| MarR |
COG1846 |
DNA-binding transcriptional regulator, MarR family [Transcription]; |
17-61 |
9.02e-05 |
|
DNA-binding transcriptional regulator, MarR family [Transcription];
Pssm-ID: 441451 [Multi-domain] Cd Length: 142 Bit Score: 42.26 E-value: 9.02e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 2570555858 17 VLNTIRKKGNVSRADIAHITGLNKSTVSFLVDELINEGFV-REEGP 61
Cdd:COG1846 43 VLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVeREPDP 88
|
|
| MarR_2 |
pfam12802 |
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ... |
17-62 |
2.27e-04 |
|
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.
Pssm-ID: 432797 [Multi-domain] Cd Length: 60 Bit Score: 38.72 E-value: 2.27e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 2570555858 17 VLNTIRKKGNVSRADIAHITGLNKSTVSFLVDELINEGFV-REEGPG 62
Cdd:pfam12802 10 VLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVeREPSPA 56
|
|
| HTH_ICLR |
smart00346 |
helix_turn_helix isocitrate lyase regulation; |
17-64 |
5.67e-04 |
|
helix_turn_helix isocitrate lyase regulation;
Pssm-ID: 214629 [Multi-domain] Cd Length: 91 Bit Score: 38.72 E-value: 5.67e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 2570555858 17 VLNTI-RKKGNVSRADIAHITGLNKSTVSFLVDELINEGFVREEGPGES 64
Cdd:smart00346 10 VLRALaEEPGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQDGQNGR 58
|
|
| PRK09557 |
PRK09557 |
fructokinase; Reviewed |
184-344 |
5.73e-04 |
|
fructokinase; Reviewed
Pssm-ID: 236565 [Multi-domain] Cd Length: 301 Bit Score: 41.55 E-value: 5.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 184 KVQIDNEANVGAIGEKWFGAGIKYNNLVYVSAGIGIGTGIIINGELYRGTVGLAGEMGH-----MTINILDH----QCSC 254
Cdd:PRK09557 99 EVRLANDANCLAVSEAVDGAAAGKQTVFAVIIGTGCGAGVAINGRVHIGGNGIAGEWGHnplpwMDEDELRYrnevPCYC 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 255 GNTGCWENYASEKALF-DYihtqlimgksdnyiNKDNFNTLSALDIINYAQKGSEIAVEALKEIGRKLGVGIVNVINTFN 333
Cdd:PRK09557 179 GKQGCIETFISGTGFAtDY--------------RRLSGKALKGSEIIRLVEEGDPVAELAFRRYEDRLAKSLAHVINILD 244
|
170
....*....|.
gi 2570555858 334 PELVIIGNTLS 344
Cdd:PRK09557 245 PDVIVLGGGMS 255
|
|
| HTH_IclR |
pfam09339 |
IclR helix-turn-helix domain; |
30-60 |
7.85e-04 |
|
IclR helix-turn-helix domain;
Pssm-ID: 430539 [Multi-domain] Cd Length: 52 Bit Score: 37.00 E-value: 7.85e-04
10 20 30
....*....|....*....|....*....|.
gi 2570555858 30 ADIAHITGLNKSTVSFLVDELINEGFVREEG 60
Cdd:pfam09339 22 TEIARRTGLPKSTAHRLLQTLVELGYVEQDP 52
|
|
| HTH_24 |
pfam13412 |
Winged helix-turn-helix DNA-binding; |
17-56 |
8.89e-04 |
|
Winged helix-turn-helix DNA-binding;
Pssm-ID: 404317 [Multi-domain] Cd Length: 45 Bit Score: 36.64 E-value: 8.89e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2570555858 17 VLNTIRKKGNVSRADIAHITGLNKSTVSFLVDELINEGFV 56
Cdd:pfam13412 6 ILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
|
|
| PRK05082 |
PRK05082 |
N-acetylmannosamine kinase; Provisional |
224-386 |
1.05e-03 |
|
N-acetylmannosamine kinase; Provisional
Pssm-ID: 235338 [Multi-domain] Cd Length: 291 Bit Score: 40.67 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 224 IINGELYRGTVGLAGEMGHMTINILDHQCSCGNTGCWENYASEKAlfdyihtqlIMGKSdnyinKDNFNTLSALDIINYA 303
Cdd:PRK05082 138 VLNGKLLTGPGGLAGHIGHTLADPHGPVCGCGRRGCVEAIASGRA---------IAAAA-----QGWLAGCDAKTIFERA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 304 QKGSEIAVEALKEIGRKLGVGIVNVINTFNPELVIIGNTLSLARGLiLDEILKEVEKKCLVYRyhkVKIKTSKLQFHAGA 383
Cdd:PRK05082 204 GQGDEQAQALINRSAQAIARLIADLKATLDCQCVVLGGSVGLAEGY-LELVQAYLAQEPAIYH---VPLLAAHYRHDAGL 279
|
...
gi 2570555858 384 IGA 386
Cdd:PRK05082 280 LGA 282
|
|
| COG2512 |
COG2512 |
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ... |
17-72 |
1.29e-03 |
|
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];
Pssm-ID: 442002 [Multi-domain] Cd Length: 80 Bit Score: 37.20 E-value: 1.29e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 2570555858 17 VLNTIRKK-GNVSRADIAHITGLNKSTVSFLVDELINEGFVREEgpgesKGGRKPII 72
Cdd:COG2512 20 VLELLRENgGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKE-----RVGRENVV 71
|
|
| HTH_CRP |
cd00092 |
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ... |
27-73 |
2.65e-03 |
|
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.
Pssm-ID: 238044 [Multi-domain] Cd Length: 67 Bit Score: 36.10 E-value: 2.65e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 2570555858 27 VSRADIAHITGLNKSTVSFLVDELINEGFVreegpgeSKGGRKPIIL 73
Cdd:cd00092 26 LTRQEIADYLGLTRETVSRTLKELEEEGLI-------SRRGRGKYRV 65
|
|
| ASKHA_NBD_ROK_PPGK |
cd24058 |
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ... |
156-213 |
4.61e-03 |
|
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466908 [Multi-domain] Cd Length: 239 Bit Score: 38.32 E-value: 4.61e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570555858 156 KKGTVLMAPNL--KWENVPLKQIIENKFKIKVQIDNEANVGAIGEKWFGAGIKYNNLVYV 213
Cdd:cd24058 67 RRGVVRTAANLdkSWIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLV 126
|
|
| |
