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Conserved domains on  [gi|2572507119|ref|WP_307962361|]
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phosphopantetheine-binding protein, partial [Salinispora arenicola]

Protein Classification

acyl carrier protein( domain architecture ID 10000754)

acyl carrier protein may function as a carrier of the growing fatty acid chain in fatty acid biosynthesis or as the carrier of activated (amino) acid groups in polyketide synthases and non-ribosomal peptide synthases

CATH:  1.10.1200.10
Gene Ontology:  GO:0009245|GO:0006633|GO:0000036|GO:0000035
PubMed:  18059524|30543875|20662770
SCOP:  4000857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 17-83 5.17e-10

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 51.78  E-value: 5.17e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2572507119  17 TIAEVLRTLLG--ASTVGRDTGFFQ-LGADSLLLVRAHRQLQEALGRRFPLTHMFEHATVRRLASALDTA 83
Cdd:COG0236     9 RLAEIIAEVLGvdPEEITPDDSFFEdLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEK 78
 
Name Accession Description Interval E-value
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 17-83 5.17e-10

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 51.78  E-value: 5.17e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2572507119  17 TIAEVLRTLLG--ASTVGRDTGFFQ-LGADSLLLVRAHRQLQEALGRRFPLTHMFEHATVRRLASALDTA 83
Cdd:COG0236     9 RLAEIIAEVLGvdPEEITPDDSFFEdLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEK 78
entF PRK10252
enterobactin non-ribosomal peptide synthetase EntF;
18-88 6.79e-09

enterobactin non-ribosomal peptide synthetase EntF;


Pssm-ID: 236668 [Multi-domain]  Cd Length: 1296  Bit Score: 52.35  E-value: 6.79e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2572507119   18 IAEVLRTLLGASTVGRDTGFFQLGADSLLLVRAHRQLQEALGRRFPLTHMFEHATVRRLASALDTASDDAA 88
Cdd:PRK10252   983 IAAAFSSLLGCDVVDADADFFALGGHSLLAMKLAAQLSRQFARQVTPGQVMVASTVAKLATLLDAEEDESR 1053
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 17-74 1.09e-08

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 47.94  E-value: 1.09e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2572507119  17 TIAEVLRTLLG--ASTVGRDTGFFQLGADSLLLVRAHRQLQEALGRRFPLTHMFEHATVR 74
Cdd:pfam00550   2 RLRELLAEVLGvpAEEIDPDTDLFDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLA 61
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 18-82 6.22e-08

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 46.47  E-value: 6.22e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2572507119   18 IAEVLRtLLGASTVGRDTGFFQLGADSLLLVRAHRQLQEALGRRFPLTHMFEHATVRRLASALDT 82
Cdd:smart00823  21 VAAVLG-HAAAEAIDPDRPFRDLGLDSLMAVELRNRLEAATGLRLPATLVFDHPTPAALAEHLAA 84
 
Name Accession Description Interval E-value
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 17-83 5.17e-10

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 51.78  E-value: 5.17e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2572507119  17 TIAEVLRTLLG--ASTVGRDTGFFQ-LGADSLLLVRAHRQLQEALGRRFPLTHMFEHATVRRLASALDTA 83
Cdd:COG0236     9 RLAEIIAEVLGvdPEEITPDDSFFEdLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEK 78
entF PRK10252
enterobactin non-ribosomal peptide synthetase EntF;
18-88 6.79e-09

enterobactin non-ribosomal peptide synthetase EntF;


Pssm-ID: 236668 [Multi-domain]  Cd Length: 1296  Bit Score: 52.35  E-value: 6.79e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2572507119   18 IAEVLRTLLGASTVGRDTGFFQLGADSLLLVRAHRQLQEALGRRFPLTHMFEHATVRRLASALDTASDDAA 88
Cdd:PRK10252   983 IAAAFSSLLGCDVVDADADFFALGGHSLLAMKLAAQLSRQFARQVTPGQVMVASTVAKLATLLDAEEDESR 1053
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 17-74 1.09e-08

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 47.94  E-value: 1.09e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2572507119  17 TIAEVLRTLLG--ASTVGRDTGFFQLGADSLLLVRAHRQLQEALGRRFPLTHMFEHATVR 74
Cdd:pfam00550   2 RLRELLAEVLGvpAEEIDPDTDLFDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLA 61
PRK12467 PRK12467
peptide synthase; Provisional
 18-91 4.24e-08

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 50.16  E-value: 4.24e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2572507119   18 IAEVLRTLLGASTVGRDTGFFQLGADSLLLVRAHRQLQEALGRRFPLTHMFEHATVRRLASALDTASDDAADQL 91
Cdd:PRK12467  1035 LAAIWADVLKVERVGLTDNFFELGGHSLLATQVISRVRQRLGIQVPLRTLFEHQTLAGFAQAVAAQQQGAQPAL 1108
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 18-82 6.22e-08

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 46.47  E-value: 6.22e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2572507119   18 IAEVLRtLLGASTVGRDTGFFQLGADSLLLVRAHRQLQEALGRRFPLTHMFEHATVRRLASALDT 82
Cdd:smart00823  21 VAAVLG-HAAAEAIDPDRPFRDLGLDSLMAVELRNRLEAATGLRLPATLVFDHPTPAALAEHLAA 84
PRK12316 PRK12316
peptide synthase; Provisional
 18-91 5.48e-07

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 46.87  E-value: 5.48e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2572507119   18 IAEVLRTLLGASTVGRDTGFFQLGADSLLLVRAHRQLQEALGRRFPLTHMFEHATVRRLASALDTASDDAADQL 91
Cdd:PRK12316  5077 VAAIWAEVLQLERVGLDDNFFELGGHSLLAIQVTSRIQLELGLELPLRELFQTPTLAAFVELAAAAGSGDDEKF 5150
PRK05691 PRK05691
peptide synthase; Validated
 17-91 5.87e-06

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 44.00  E-value: 5.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2572507119   17 TIAEVLRTLLGASTVGRDTGFFQLGADSLLLVRAHRQLQEALGRRFPLTHMFEHATVRRLASALD-----TASDDAADQL 91
Cdd:PRK05691  4245 TLATIWADVLKVERVGVHDNFFELGGHSLLATQIASRVQKALQRNVPLRAMFECSTVEELAEYIEglagsAIDEQKVDRL 4324
PRK12467 PRK12467
peptide synthase; Provisional
 17-77 1.46e-05

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 42.84  E-value: 1.46e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2572507119   17 TIAEVLRTLLGASTVGRDTGFFQLGADSLLLVRAHRQLQEALGRRFPLTHMFEHATVRRLA 77
Cdd:PRK12467  3609 QLAAIWADVLGVEQVGVTDNFFELGGDSLLALQVLSRIRQSLGLKLSLRDLMSAPTIAELA 3669
PRK12316 PRK12316
peptide synthase; Provisional
 17-90 9.71e-05

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 40.33  E-value: 9.71e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2572507119   17 TIAEVLRTLLGASTVGRDTGFFQLGADSLLLVRAHRQLQEAlGRRFPLTHMFEHATVRRLASALDTASDDAADQ 90
Cdd:PRK12316  1022 TLAAIWQDVLGVERVGLDDNFFELGGDSIVSIQVVSRARQA-GIQLSPRDLFQHQTIRSLALVAKAGQATAADQ 1094
PRK12316 PRK12316
peptide synthase; Provisional
 18-80 1.30e-04

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 39.94  E-value: 1.30e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2572507119   18 IAEVLRTLLGASTVGRDTGFFQLGADSLLLVRAHRQLQEALGRRFPLTHMFEHATVRRLASAL 80
Cdd:PRK12316  2521 LAAIWQAVLKVEQVGLDDHFFELGGHSLLATQVVSRVRQDLGLEVPLRILFERPTLAAFAASL 2583
PRK12316 PRK12316
peptide synthase; Provisional
 17-90 3.50e-04

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 38.78  E-value: 3.50e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2572507119   17 TIAEVLRTLLGASTVGRDTGFFQLGADSLLLVRAHRQLQEAlGRRFPLTHMFEHATVRRLASALDTASDDAADQ 90
Cdd:PRK12316  3560 RLAAIWADVLKLEQVGLTDNFFELGGDSIISLQVVSRARQA-GIRFTPKDLFQHQTIQGLARVARVGGGVAVDQ 3632
PRK05691 PRK05691
peptide synthase; Validated
 17-90 3.61e-04

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 38.61  E-value: 3.61e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2572507119   17 TIAEVLRTLLGASTVGRDTGFFQLGADSLL---LVRAHRQlqeaLGRRFPLTHMFEHATVRRLASALDTASDDAADQ 90
Cdd:PRK05691  2713 QLAQIWREVLNVERVGLGDNFFELGGDSILsiqVVSRARQ----LGIHFSPRDLFQHQTVQTLAAVATHSEAAQAEQ 2785
PRK12467 PRK12467
peptide synthase; Provisional
 18-77 5.15e-03

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 35.52  E-value: 5.15e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2572507119   18 IAEVLRTLLGASTVGRDTGFFQLGADSLL---LVRAHRQlqeaLGRRFPLTHMFEHATVRRLA 77
Cdd:PRK12467  2102 LAAIWQDVLGLEQVGLHDNFFELGGDSIIsiqVVSRARQ----AGIRFTPKDLFQHQTVQSLA 2160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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