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Conserved domains on  [gi|2574628158|ref|WP_308767413.1|]
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cation diffusion facilitator family transporter

Protein Classification

cation diffusion facilitator family transporter( domain architecture ID 11414568)

cation diffusion facilitator (CDF) family transporter facilitates the active efflux of one or more from a variety of metal cations including Zn, Cd, Ni, Co, Mn, and Cu

PubMed:  25896018|17448255
TCDB:  2.A.4

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FieF COG0053
Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];
17-230 5.30e-82

Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];


:

Pssm-ID: 439823 [Multi-domain]  Cd Length: 284  Bit Score: 246.17  E-value: 5.30e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  17 LSIAAAVATIILKALAAWFTGSVGFLSDAFESIVNLVAAIAGFYALRIASKPADDNHQFGHGKAEYVSALVEGAMIFIAA 96
Cdd:COG0053     7 ASLAANLLLAVLKLVAGLLTGSVALLADALHSLSDLVASLLVLLGLRLAAKPADEEHPYGHGKAEYLASLIVAVLILLAG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  97 GMIVYTAIQRFFVPQPIEEPGWGLALSTLSSVLNAAVGIALIRAGKRYRSATLDADGHHLLTDVWTSVGVLVGIAAVYLT 176
Cdd:COG0053    87 LFILYEAIERLLHPEPVEPSGLGLAVLLISIVVNEALARYLRRVGKKTGSPALKADALHDRSDALTSLGVLIGLLLALLT 166
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2574628158 177 GWMWLDPVVALAVGINILWTGYTLLRDSVSSLLSEALPADERQQIRQLLARLEQ 230
Cdd:COG0053   167 GWPWLDPIAAILIGLLILKVAYKLARESLSLLMDEALDEELVERIRAIILSVPG 220
 
Name Accession Description Interval E-value
FieF COG0053
Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];
17-230 5.30e-82

Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];


Pssm-ID: 439823 [Multi-domain]  Cd Length: 284  Bit Score: 246.17  E-value: 5.30e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  17 LSIAAAVATIILKALAAWFTGSVGFLSDAFESIVNLVAAIAGFYALRIASKPADDNHQFGHGKAEYVSALVEGAMIFIAA 96
Cdd:COG0053     7 ASLAANLLLAVLKLVAGLLTGSVALLADALHSLSDLVASLLVLLGLRLAAKPADEEHPYGHGKAEYLASLIVAVLILLAG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  97 GMIVYTAIQRFFVPQPIEEPGWGLALSTLSSVLNAAVGIALIRAGKRYRSATLDADGHHLLTDVWTSVGVLVGIAAVYLT 176
Cdd:COG0053    87 LFILYEAIERLLHPEPVEPSGLGLAVLLISIVVNEALARYLRRVGKKTGSPALKADALHDRSDALTSLGVLIGLLLALLT 166
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2574628158 177 GWMWLDPVVALAVGINILWTGYTLLRDSVSSLLSEALPADERQQIRQLLARLEQ 230
Cdd:COG0053   167 GWPWLDPIAAILIGLLILKVAYKLARESLSLLMDEALDEELVERIRAIILSVPG 220
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
24-230 2.58e-55

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 177.41  E-value: 2.58e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  24 ATIILKALAAWFTGSVGFLSDAFESIVNLVAAIAGFYALRIASKPADDNHQFGHGKAEYVSALVEGAMIFIAAGMIVYTA 103
Cdd:TIGR01297   1 LLMLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158 104 IQRFFVPQPIEEPGWGLALSTLSSVLNAAVGIALIRAGKRYRSATLDADGHHLLTDVWTSVGVLVGIAAVYLtGWMWLDP 183
Cdd:TIGR01297  81 IERLINPEPEIDGGTMLIVAIVGLIVNLILALYLHRVGHRLGSLALRAAALHVLSDALSSVGVLIGALLIYF-GWHWADP 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2574628158 184 VVALAVGINILWTGYTLLRDSVSSLLSEALPADERQQIRQLLARLEQ 230
Cdd:TIGR01297 160 IAALLISLLILYTAFRLLKESINVLLDAAPDEEDLEEIKKAILSIPG 206
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
27-209 2.72e-43

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 144.34  E-value: 2.72e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  27 ILKALAAWFTGSVGFLSDAFESIVNLVAAIAGFYALRIASKPADDNHQFGHGKAEYVSALVEGAMIFIAAGMIVYTAIQR 106
Cdd:pfam01545   4 LVKLAAGLLTGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVFLLYESIQR 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158 107 FFVPQPIEEPGWGLALSTLSSVLNAAVGIALIRAGKRYRSATLDADGHHLLTDVWTSVGVLVGIAAVYL---TGWMWLDP 183
Cdd:pfam01545  84 LLSPGEEIDPGLALILALVSLLVNLFLLLYLRRAARRIRSPALKADALHALSDVLASLGVLISALLIYLgpiTGGLLADP 163
                         170       180
                  ....*....|....*....|....*.
gi 2574628158 184 VVALAVGINILWTGYTLLRDSVSSLL 209
Cdd:pfam01545 164 LASLLIGLLILYTALRLLKESLSILL 189
fieF PRK09509
CDF family cation-efflux pump FieF;
20-229 4.77e-36

CDF family cation-efflux pump FieF;


Pssm-ID: 181919 [Multi-domain]  Cd Length: 299  Bit Score: 128.64  E-value: 4.77e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  20 AAAVATIIL--KALAAWFTGSVGFLSDAFESIVNLVAAIAGFYALRIASKPADDNHQFGHGKAEYVSALVEGAMIFIAAG 97
Cdd:PRK09509   16 ATAMASLLLliKIFAWWYTGSVSLLAALVDSLVDIAASLTNLLVVRYSLQPADDEHTFGHGKAESLAALAQSMFISGSAL 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  98 MIVYTAIQRFFVPQPIEEPGWGLALSTLSSVLNAAVGIALIRAGKRYRSATLDADGHHLLTDVWTSVGVLVGIAAVYLtG 177
Cdd:PRK09509   96 FLFLTGIQHLISPTPMNDPGVGIIVTLVALICTLILVTFQRWVVRKTQSQAVRADMLHYQSDVMMNGAILLALGLSWY-G 174
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2574628158 178 WMWLDPVVALAVGINILWTGYTLLRDSVSSLLSEALPADERQQIRQLLARLE 229
Cdd:PRK09509  175 WHRADALFALGIGIYILYSALRMGYEAVQSLLDRALPDEERQEIIDIVTSWP 226
 
Name Accession Description Interval E-value
FieF COG0053
Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];
17-230 5.30e-82

Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];


Pssm-ID: 439823 [Multi-domain]  Cd Length: 284  Bit Score: 246.17  E-value: 5.30e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  17 LSIAAAVATIILKALAAWFTGSVGFLSDAFESIVNLVAAIAGFYALRIASKPADDNHQFGHGKAEYVSALVEGAMIFIAA 96
Cdd:COG0053     7 ASLAANLLLAVLKLVAGLLTGSVALLADALHSLSDLVASLLVLLGLRLAAKPADEEHPYGHGKAEYLASLIVAVLILLAG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  97 GMIVYTAIQRFFVPQPIEEPGWGLALSTLSSVLNAAVGIALIRAGKRYRSATLDADGHHLLTDVWTSVGVLVGIAAVYLT 176
Cdd:COG0053    87 LFILYEAIERLLHPEPVEPSGLGLAVLLISIVVNEALARYLRRVGKKTGSPALKADALHDRSDALTSLGVLIGLLLALLT 166
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2574628158 177 GWMWLDPVVALAVGINILWTGYTLLRDSVSSLLSEALPADERQQIRQLLARLEQ 230
Cdd:COG0053   167 GWPWLDPIAAILIGLLILKVAYKLARESLSLLMDEALDEELVERIRAIILSVPG 220
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
24-230 2.58e-55

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 177.41  E-value: 2.58e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  24 ATIILKALAAWFTGSVGFLSDAFESIVNLVAAIAGFYALRIASKPADDNHQFGHGKAEYVSALVEGAMIFIAAGMIVYTA 103
Cdd:TIGR01297   1 LLMLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158 104 IQRFFVPQPIEEPGWGLALSTLSSVLNAAVGIALIRAGKRYRSATLDADGHHLLTDVWTSVGVLVGIAAVYLtGWMWLDP 183
Cdd:TIGR01297  81 IERLINPEPEIDGGTMLIVAIVGLIVNLILALYLHRVGHRLGSLALRAAALHVLSDALSSVGVLIGALLIYF-GWHWADP 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2574628158 184 VVALAVGINILWTGYTLLRDSVSSLLSEALPADERQQIRQLLARLEQ 230
Cdd:TIGR01297 160 IAALLISLLILYTAFRLLKESINVLLDAAPDEEDLEEIKKAILSIPG 206
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
27-209 2.72e-43

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 144.34  E-value: 2.72e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  27 ILKALAAWFTGSVGFLSDAFESIVNLVAAIAGFYALRIASKPADDNHQFGHGKAEYVSALVEGAMIFIAAGMIVYTAIQR 106
Cdd:pfam01545   4 LVKLAAGLLTGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVFLLYESIQR 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158 107 FFVPQPIEEPGWGLALSTLSSVLNAAVGIALIRAGKRYRSATLDADGHHLLTDVWTSVGVLVGIAAVYL---TGWMWLDP 183
Cdd:pfam01545  84 LLSPGEEIDPGLALILALVSLLVNLFLLLYLRRAARRIRSPALKADALHALSDVLASLGVLISALLIYLgpiTGGLLADP 163
                         170       180
                  ....*....|....*....|....*.
gi 2574628158 184 VVALAVGINILWTGYTLLRDSVSSLL 209
Cdd:pfam01545 164 LASLLIGLLILYTALRLLKESLSILL 189
CzcD COG1230
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
12-229 1.03e-40

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 140.64  E-value: 1.03e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  12 ERFMQLSIAAAVATIILKALAAWFTGSVGFLSDAFESIVNLVAAIAGFYALRIASKPADDNHQFGHGKAEYVSALVEGAM 91
Cdd:COG1230    17 ERRLLIALALTLGFMVVEIVGGLLSGSLALLADAGHMLSDALALGLALFAYRLARRPADARFTFGYKRAEILAALANALL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  92 IFIAAGMIVYTAIQRFFVPQPIEePGWGLALSTLSSVLNAAVgIALIRAGKRY----RSATLdadghHLLTDVWTSVGVL 167
Cdd:COG1230    97 LLVVAGYILYEAIQRLFNPPPVA-GGGMLVVAVIGLVVNLVS-AWLLHRGSKHdlnlRGAYL-----HVLADALGSVAVI 169
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2574628158 168 VGIAAVYLTGWMWLDPVVALAVGINILWTGYTLLRDSVSSLLsEALPAD-ERQQIRQLLARLE 229
Cdd:COG1230   170 VAALVILFTGWTWLDPLLSLLIALLILRSAWGLLRESLRILL-EGVPDGiDLEEVRAALEALP 231
fieF PRK09509
CDF family cation-efflux pump FieF;
20-229 4.77e-36

CDF family cation-efflux pump FieF;


Pssm-ID: 181919 [Multi-domain]  Cd Length: 299  Bit Score: 128.64  E-value: 4.77e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  20 AAAVATIIL--KALAAWFTGSVGFLSDAFESIVNLVAAIAGFYALRIASKPADDNHQFGHGKAEYVSALVEGAMIFIAAG 97
Cdd:PRK09509   16 ATAMASLLLliKIFAWWYTGSVSLLAALVDSLVDIAASLTNLLVVRYSLQPADDEHTFGHGKAESLAALAQSMFISGSAL 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  98 MIVYTAIQRFFVPQPIEEPGWGLALSTLSSVLNAAVGIALIRAGKRYRSATLDADGHHLLTDVWTSVGVLVGIAAVYLtG 177
Cdd:PRK09509   96 FLFLTGIQHLISPTPMNDPGVGIIVTLVALICTLILVTFQRWVVRKTQSQAVRADMLHYQSDVMMNGAILLALGLSWY-G 174
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2574628158 178 WMWLDPVVALAVGINILWTGYTLLRDSVSSLLSEALPADERQQIRQLLARLE 229
Cdd:PRK09509  175 WHRADALFALGIGIYILYSALRMGYEAVQSLLDRALPDEERQEIIDIVTSWP 226
PRK03557 PRK03557
CDF family zinc transporter ZitB;
16-227 1.67e-17

CDF family zinc transporter ZitB;


Pssm-ID: 235130 [Multi-domain]  Cd Length: 312  Bit Score: 79.41  E-value: 1.67e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  16 QLSIAAAVATI--ILKALAAWFTGSVGFLSDAFESIVNLVAAIAGFYALRIASKPADDNHQFGHGKAEYVSALVEGAMIF 93
Cdd:PRK03557   20 RLLYAFGVTAGfmLVEVIGGFLSGSLALLADAGHMLTDAAALLFALLAVQFSRRPPTIRHTFGWLRLTTLAAFVNAIALV 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  94 IAAGMIVYTAIQRFFVPQPIEepGWGLALSTLSSVLNAAVGIALIRAGKRYRSATLDADGHHLLTDVWTSVGVLVGIAAV 173
Cdd:PRK03557  100 VITILIVWEAIERFRTPRPVA--GGMMMAIAVAGLLANILSFWLLHHGSEEKNLNVRAAALHVLGDLLGSVGAIIAALII 177
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2574628158 174 YLTGWMWLDPVVALAVGINILWTGYTLLRDSVSSLLSEALPADERQQIRQLLAR 227
Cdd:PRK03557  178 IWTGWTPADPILSILVSVLVLRSAWRLLKESVNELLEGAPVSLDIAELKRRLCR 231
COG3965 COG3965
Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and ...
7-230 6.32e-17

Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and metabolism];


Pssm-ID: 443165 [Multi-domain]  Cd Length: 300  Bit Score: 77.56  E-value: 6.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158   7 EQRILerfmQLSIAAAVATIILKALAAWFTGSVGFLSDAFESIVNLVAAIAGFYALRIASKPADDNHQFGHGKAEYVSAL 86
Cdd:COG3965     4 EQRLL----KLSIAGTLLFAVLGIVFGLLSGSQAILFDGVYSLIDAGMTLLSLLVARLIARPDSRRFQFGYWHLEPLVLA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2574628158  87 VEGAMIFIAAGMIVYTAIQRFFVPQPIEEPGWGLALSTLSSVLNAAVGIALIRAGKRYRSATLDADGHHLLTDVWTSVGV 166
Cdd:COG3965    80 IKGLILLLLCLYALVNAVGSLLDGGREIEFGLALVYALVATVGCFGIALYLRRANRRLRSELVRLDAKAWLMDGLLSAAL 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2574628158 167 LVGIAAVYL---TGWMWL----DPVVALAVGINILWTGYTLLRDSVSSLLSEALPADERQQIRQLLARLEQ 230
Cdd:COG3965   160 LVAFILAYLlqgTGLAWLapyvDPAILALLSLVFLPVPLRIVRQALREVLLMAPPEELDARVREVMEAIVA 230
 
Blast search parameters
Data Source: Live blast search RID = P4YTX3FR016
User Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01   Maximum number of hits: 500

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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