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Conserved domains on  [gi|2575794190|ref|WP_309332305|]
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response regulator [Sutterella sp.]

Protein Classification

response regulator transcription factor( domain architecture ID 11468274)

response regulator transcription factor with a signal receiver (REC) domain and a LuxR family helix-turn-helix (HTH) domain that may be part of a two-component regulatory system; it receives the signal from the sensor partner, binds DNA upon phosphorylation, and functions as a transcriptional regulator

CATH:  3.40.50.2300|1.10.10.10
Gene Ontology:  GO:0000160|GO:0000156|GO:0003677|GO:0006355
PubMed:  20226724|15808743|10966457
SCOP:  4003632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 13-208 1.64e-72

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 218.43  E-value: 1.64e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  13 LIRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAH 92
Cdd:COG4566     1 TVYIVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTGH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  93 GDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKSRGAVG-DSTPGALVAAWNTLTDREKEVAKLVAEGLLNREVGE 171
Cdd:COG4566    81 GDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALARDRARRAeRARRAELRARLASLTPREREVLDLVVAGLSNKQIAR 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2575794190 172 RLgGIAVKTVQVHRSEACSKLGVKGAAGLAQAVRAVE 208
Cdd:COG4566   161 EL-GISPRTVEVHRANVMEKLGARSLAELVRLALALG 196
 
Name Accession Description Interval E-value
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 13-208 1.64e-72

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 218.43  E-value: 1.64e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  13 LIRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAH 92
Cdd:COG4566     1 TVYIVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTGH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  93 GDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKSRGAVG-DSTPGALVAAWNTLTDREKEVAKLVAEGLLNREVGE 171
Cdd:COG4566    81 GDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALARDRARRAeRARRAELRARLASLTPREREVLDLVVAGLSNKQIAR 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2575794190 172 RLgGIAVKTVQVHRSEACSKLGVKGAAGLAQAVRAVE 208
Cdd:COG4566   161 EL-GISPRTVEVHRANVMEKLGARSLAELVRLALALG 196
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 12-127 3.83e-45

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 146.20  E-value: 3.83e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  12 PLIRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSA 91
Cdd:cd17537     1 ATVYVVDDDEAVRDSLAFLLRSVGLAVKTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITG 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2575794190  92 HGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAM 127
Cdd:cd17537    81 HGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAIEQAL 116
fixJ PRK09390
response regulator FixJ; Provisional
 12-215 1.26e-42

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 142.45  E-value: 1.26e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  12 PLIRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSA 91
Cdd:PRK09390    4 GVVHVVDDDEAMRDSLAFLLDSAGFEVRLFESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVMTG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  92 HGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKS-RGAVGDSTPGALVAAWNTLTDREKEVAKLVAEGLLNREVG 170
Cdd:PRK09390   84 HGDVPLAVEAMKLGAVDFIEKPFEDERLIGAIERALAQApEAAKSEAVAADIRARIASLSERERQVMDGLVAGLSNKVIA 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2575794190 171 ERLgGIAVKTVQVHRSEACSKLgvkGAAGLAQAVRaveMALKVRQ 215
Cdd:PRK09390  164 RDL-DISPRTVEVYRANVMTKM---QAGSLSELVR---MALRAGR 201
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 16-123 1.37e-25

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 95.68  E-value: 1.37e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDL 95
Cdd:pfam00072   3 IVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHGDE 82

                          90       100
                  ....*....|....*....|....*...
gi 2575794190  96 DMAVDAMRRGACAFIQKTADRARLLQAI 123
Cdd:pfam00072  83 DDAVEALEAGADDFLSKPFDPDELLAAI 110
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 146-205 2.80e-14

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 64.86  E-value: 2.80e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  146 WNTLTDREKEVAKLVAEGLLNREVGERLgGIAVKTVQVHRSEACSKLGVKgaaGLAQAVR 205
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERL-GISEKTVKTHLSNIMRKLGVR---SRTQAVR 56
 
Name Accession Description Interval E-value
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 13-208 1.64e-72

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 218.43  E-value: 1.64e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  13 LIRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAH 92
Cdd:COG4566     1 TVYIVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTGH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  93 GDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKSRGAVG-DSTPGALVAAWNTLTDREKEVAKLVAEGLLNREVGE 171
Cdd:COG4566    81 GDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALARDRARRAeRARRAELRARLASLTPREREVLDLVVAGLSNKQIAR 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2575794190 172 RLgGIAVKTVQVHRSEACSKLGVKGAAGLAQAVRAVE 208
Cdd:COG4566   161 EL-GISPRTVEVHRANVMEKLGARSLAELVRLALALG 196
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 12-127 3.83e-45

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 146.20  E-value: 3.83e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  12 PLIRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSA 91
Cdd:cd17537     1 ATVYVVDDDEAVRDSLAFLLRSVGLAVKTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITG 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2575794190  92 HGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAM 127
Cdd:cd17537    81 HGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAIEQAL 116
fixJ PRK09390
response regulator FixJ; Provisional
 12-215 1.26e-42

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 142.45  E-value: 1.26e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  12 PLIRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSA 91
Cdd:PRK09390    4 GVVHVVDDDEAMRDSLAFLLDSAGFEVRLFESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVMTG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  92 HGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKS-RGAVGDSTPGALVAAWNTLTDREKEVAKLVAEGLLNREVG 170
Cdd:PRK09390   84 HGDVPLAVEAMKLGAVDFIEKPFEDERLIGAIERALAQApEAAKSEAVAADIRARIASLSERERQVMDGLVAGLSNKVIA 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2575794190 171 ERLgGIAVKTVQVHRSEACSKLgvkGAAGLAQAVRaveMALKVRQ 215
Cdd:PRK09390  164 RDL-DISPRTVEVYRANVMTKM---QAGSLSELVR---MALRAGR 201
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 16-131 1.96e-28

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 103.72  E-value: 1.96e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDL 95
Cdd:cd17549     3 LVDDDADVREALQQTLELAGFRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITGHGDV 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2575794190  96 DMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKSR 131
Cdd:cd17549    83 PMAVEAMRAGAYDFLEKPFDPERLLDVVRRALEKRR 118
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 16-131 9.87e-26

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 103.12  E-value: 9.87e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDL 95
Cdd:COG2204     7 VVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLTGYGDV 86

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2575794190  96 DMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKSR 131
Cdd:COG2204    87 ETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRR 122
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 16-123 1.37e-25

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 95.68  E-value: 1.37e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDL 95
Cdd:pfam00072   3 IVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHGDE 82

                          90       100
                  ....*....|....*....|....*...
gi 2575794190  96 DMAVDAMRRGACAFIQKTADRARLLQAI 123
Cdd:pfam00072  83 DDAVEALEAGADDFLSKPFDPDELLAAI 110
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 14-126 1.26e-22

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 88.32  E-value: 1.26e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHG 93
Cdd:cd17550     1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMISGHG 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2575794190  94 DLDMAVDAMRRGACAFIQKTADRARLLQAIVDA 126
Cdd:cd17550    81 TIETAVKATKLGAYDFIEKPLSLDRLLLTIERA 113
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 16-112 3.51e-20

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 81.50  E-value: 3.51e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDL 95
Cdd:cd00156     2 IVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKADE 81

                          90
                  ....*....|....*..
gi 2575794190  96 DMAVDAMRRGACAFIQK 112
Cdd:cd00156    82 EDAVRALELGADDYLVK 98
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 16-132 8.09e-19

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 78.74  E-value: 8.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAE---SFLKGDTPSrpgCLLLDVQMDGMTGLELQEEM--IWRGITLPIVFLS 90
Cdd:COG0784    10 VVDDNPDNRELLRRLLERLGYEVTTAEDGAealELLRAGPPD---LILLDINMPGMDGLELLRRIraLPRLPDIPIIALT 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2575794190  91 AHGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKSRG 132
Cdd:COG0784    87 AYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARASA 128
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 11-123 8.21e-18

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 77.64  E-value: 8.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  11 TPLIRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEM--IWRGITLPIVF 88
Cdd:COG3706     1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLraDPRTADIPIIF 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2575794190  89 LSAHGDLDMAVDAMRRGACAFIQKTADRARLLQAI 123
Cdd:COG3706    81 LTALDDEEDRARALEAGADDYLTKPFDPEELLARV 115
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 16-134 2.84e-17

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 76.53  E-value: 2.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDL 95
Cdd:COG0745     6 VVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLTARDDE 85

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2575794190  96 DMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKSRGAV 134
Cdd:COG0745    86 EDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAAEV 124
PRK15369 PRK15369
two component system response regulator;
55-205 3.44e-17

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 76.66  E-value: 3.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  55 RPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDLDMAVDAMRRGACAFIQKTADRARLLQAI----------- 123
Cdd:PRK15369   49 EPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVLTARQEEHMASRTLAAGALGYVLKKSPQQILLAAIqtvavgkryid 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190 124 ----VDAMAKSRGAVGDSTPgalvaawnTLTDREKEVAKLVAEGLLNREVGERLgGIAVKTVQVHRSEACSKLGVKGAAG 199
Cdd:PRK15369  129 palnREAILALLNADDTNPP--------LLTPRERQILKLITEGYTNRDIAEQL-SISIKTVETHRLNMMRKLDVHKVAE 199


                  ....*.
gi 2575794190 200 LAQAVR 205
Cdd:PRK15369  200 LLNWAR 205
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 16-131 4.89e-17

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 74.24  E-value: 4.89e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFML-KHEGFECC-VYPTAES---FLKGDtpsRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLS 90
Cdd:COG4565     8 IVEDDPMVAELLRRYLeRLPGFEVVgVASSGEEalaLLAEH---RPDLILLDIYLPDGDGLELLRELRARGPDVDVIVIT 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2575794190  91 AHGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKSR 131
Cdd:COG4565    85 AARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRR 125
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 16-112 1.23e-16

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 72.11  E-value: 1.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFML-KHEGFECCVypTAES------FLKGDTPSrpgCLLLDVQMDGMTGLELQEEMIWRGITLPIVF 88
Cdd:COG4753     4 IVDDEPLIREGLKRILeWEAGFEVVG--EAENgeealeLLEEHKPD---LVITDINMPGMDGLELLEAIRELDPDTKIII 78

                          90       100
                  ....*....|....*....|....
gi 2575794190  89 LSAHGDLDMAVDAMRRGACAFIQK 112
Cdd:COG4753    79 LSGYSDFEYAQEAIKLGADDYLLK 102
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 16-123 2.08e-16

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 74.85  E-value: 2.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFML-KHEGFECC-VYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHG 93
Cdd:COG3279     6 IVDDEPLARERLERLLeKYPDLEVVgEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFTTAYD 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 2575794190  94 dlDMAVDAMRRGACAFIQKTADRARLLQAI 123
Cdd:COG3279    86 --EYALEAFEVNAVDYLLKPIDEERLAKAL 113
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 8-126 6.85e-16

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 72.26  E-value: 6.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190   8 TAETPLIRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIV 87
Cdd:COG4567     1 SAEDRSLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIV 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2575794190  88 FLSAHGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDA 126
Cdd:COG4567    81 VLTGYASIATAVEAIKLGADDYLAKPADADDLLAALERA 119
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 16-128 3.52e-15

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 68.69  E-value: 3.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFML-KHEGFEccVYPTAESflkGDTPS------RPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVF 88
Cdd:cd17535     3 IVDDHPLVREGLRRLLeSEPDIE--VVGEAAD---GEEALallrelRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2575794190  89 LSAHGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMA 128
Cdd:cd17535    78 LTAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 7-131 4.93e-15

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 70.96  E-value: 4.93e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190   7 TTAETPLIRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEM--IWRGITL 84
Cdd:COG3437     2 RTGQAPTVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLraDPSTRDI 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2575794190  85 PIVFLSAHGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKSR 131
Cdd:COG3437    82 PVIFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRR 128
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 31-127 9.20e-15

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 67.99  E-value: 9.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  31 LKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDLDMAVDAMRRGACAFI 110
Cdd:cd17572    18 LSDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITAHGSVDIAVEAMRLGAYDFL 97

                          90
                  ....*....|....*..
gi 2575794190 111 QKTADRARLLQAIVDAM 127
Cdd:cd17572    98 EKPFDADRLRVTVRNAL 114
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 16-211 1.42e-14

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 67.61  E-value: 1.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHE-GFECC-VYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMiwrgitlpivflsahg 93
Cdd:COG2197     6 IVDDHPLVREGLRALLEAEpDIEVVgEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL---------------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  94 dldmavdamrrgacafiqktadrarllqaivdamaksrgavgdstpgalvaawntLTDREKEVAKLVAEGLLNREVGERL 173
Cdd:COG2197    70 -------------------------------------------------------LTPREREVLRLLAEGLSNKEIAERL 94

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2575794190 174 gGIAVKTVQVHRSEACSKLGVKGAAGLaqAVRAVEMAL 211
Cdd:COG2197    95 -GISERTVKTHVSNILRKLGVRNRTEL--VLLALRLGL 129
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 146-205 2.80e-14

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 64.86  E-value: 2.80e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  146 WNTLTDREKEVAKLVAEGLLNREVGERLgGIAVKTVQVHRSEACSKLGVKgaaGLAQAVR 205
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERL-GISEKTVKTHLSNIMRKLGVR---SRTQAVR 56
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 16-129 3.07e-14

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 66.59  E-value: 3.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAES------FLKGdtpSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFL 89
Cdd:cd17536     3 IVDDEPLIREGLKKLIDWEELGFEVVGEAENgeealeLIEE---HKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIIL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2575794190  90 SAHGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMAK 129
Cdd:cd17536    80 SGYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALEKAKEE 119
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 16-106 3.50e-14

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 65.51  E-value: 3.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDL 95
Cdd:cd17574     2 VVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKDEE 81

                          90
                  ....*....|.
gi 2575794190  96 DMAVDAMRRGA 106
Cdd:cd17574    82 EDKVLGLELGA 92
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 13-115 3.69e-14

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 70.28  E-value: 3.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  13 LIRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAH 92
Cdd:PRK10923    5 IVWVVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAH 84

                          90       100
                  ....*....|....*....|...
gi 2575794190  93 GDLDMAVDAMRRGACAFIQKTAD 115
Cdd:PRK10923   85 SDLDAAVSAYQQGAFDYLPKPFD 107
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 16-115 6.01e-14

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 65.76  E-value: 6.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDL 95
Cdd:cd19919     5 IVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMTAHSDL 84

                          90       100
                  ....*....|....*....|
gi 2575794190  96 DMAVDAMRRGACAFIQKTAD 115
Cdd:cd19919    85 DSAVSAYQGGAFEYLPKPFD 104
PRK15115 PRK15115
response regulator GlrR; Provisional
 16-162 2.88e-13

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 67.94  E-value: 2.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDL 95
Cdd:PRK15115   10 LVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVIILTAHGSI 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2575794190  96 DMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKSRGAVGDSTPGALVAAwNTLTDREKEVAKLVAE 162
Cdd:PRK15115   90 PDAVAATQQGVFSFLTKPVDRDALYKAIDDALEQSAPATDERWREAIVTR-SPLMLRLLEQARMVAQ 155
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 12-123 2.99e-12

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 61.06  E-value: 2.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  12 PLIRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSA 91
Cdd:cd17555     1 ATILVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVSG 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2575794190  92 HGDLDMAVDAMRRGACAFIQK-TADRARLLQAI 123
Cdd:cd17555    81 AGVMSDAVEALRLGAWDYLTKpIEDLAVLEHAV 113
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 149-206 5.14e-12

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 59.20  E-value: 5.14e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2575794190 149 LTDREKEVAKLVAEGLLNREVGERLgGIAVKTVQVHRSEACSKLGVKGAaglAQAVRA 206
Cdd:COG5905    13 LTKREREVLELLAEGLTNKEIARQL-FISEKTVKNHVSNILRKLGVRNR---VQAVVW 66
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 149-205 6.75e-12

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 58.31  E-value: 6.75e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2575794190 149 LTDREKEVAKLVAEGLLNREVGERLgGIAVKTVQVHRSEACSKLGVKgaaGLAQAVR 205
Cdd:cd06170     1 LTPREREVLRLLAEGKTNKEIADIL-GISEKTVKTHLRNIMRKLGVK---SRTQLVA 53
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 7-195 1.16e-11

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 61.58  E-value: 1.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190   7 TTAETPLIRIVDDEERMRESLAFMLKHEGfECCVYPTAESFLKGDTPS---RPGCLLLDVQMDGMTGLELQEEMIWRGIT 83
Cdd:PRK10651    2 SNQEPATILLIDDHPMLRTGVKQLISMAP-DITVVGEASNGEQGIELAeslDPDLILLDLNMPGMNGLETLDKLREKSLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  84 LPIVFLSAHGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAmAKSRGAVGDSTPGALVAAW-----------NTLTDR 152
Cdd:PRK10651   81 GRIVVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQA-AAGEMVLSEALTPVLAASLranratterdvNQLTPR 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2575794190 153 EKEVAKLVAEGLLNREVGERLgGIAVKTVQVHRSEACSKLGVK 195
Cdd:PRK10651  160 ERDILKLIAQGLPNKMIARRL-DITESTVKVHVKHMLKKMKLK 201
PRK10360 PRK10360
transcriptional regulator UhpA;
14-202 5.76e-11

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 59.61  E-value: 5.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCV--YPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIwRGitLPIVFLSA 91
Cdd:PRK10360    4 VALIDDHLIVRSGFAQLLGLEPDLQVVaeFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLP-KG--MATIMLSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  92 HGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKSRGAVGDSTPGALVAAWNTLTDREKEVAKLVAEGLLNREVGE 171
Cdd:PRK10360   81 HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAA 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2575794190 172 RLgGIAVKTVQVHRSEACSKLGVKGAAGLAQ 202
Cdd:PRK10360  161 EL-GLSPKTVHVHRANLMEKLGVSNDVELAR 190
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 16-122 1.29e-10

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 56.68  E-value: 1.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDL 95
Cdd:cd17563     5 LVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLTGYASI 84

                          90       100
                  ....*....|....*....|....*..
gi 2575794190  96 DMAVDAMRRGACAFIQKTADRARLLQA 122
Cdd:cd17563    85 ATAVEAIKLGADDYLAKPADADEILAA 111
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
80-206 1.34e-10

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 58.23  E-value: 1.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  80 RGITLPIVFLSAHGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKSRGAVGDSTPGALVAAWNTLTDREKEVAKL 159
Cdd:COG2771    59 AAALLLGLLLLLLIALLLLLLLLLALLLLLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREVLRL 138

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2575794190 160 VAEGLLNREVGERLgGIAVKTVQVHRSEACSKLGVKGAAGLAQAVRA 206
Cdd:COG2771   139 LAEGLTLKEIARIL-GISERTVRTHLKRIYRKLGVSSRAELVALALR 184
GerE pfam00196
Bacterial regulatory proteins, luxR family;
148-205 1.38e-10

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 54.90  E-value: 1.38e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2575794190 148 TLTDREKEVAKLVAEGLLNREVGERLgGIAVKTVQVHRSEACSKLGVKgaaGLAQAVR 205
Cdd:pfam00196   2 SLSPREREVLRWLAAGKSNKEIADEL-GISEKTVKVHRSNIMRKLNVH---SRVELVR 55
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
14-159 1.59e-10

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 59.86  E-value: 1.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHG 93
Cdd:PRK11361    7 ILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTAYA 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2575794190  94 DLDMAVDAMRRGACAFIQKTAD---------RARLLQAIVDAMAKSRGAVGDS-TPGALVAAWNTLTDREKEVAKL 159
Cdd:PRK11361   87 EVETAVEALRCGAFDYVIKPFDldelnlivqRALQLQSMKKEIRHLHQALSTSwQWGHILTNSPAMMDICKDTAKI 162
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 14-112 2.68e-10

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 55.53  E-value: 2.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGiTLPIVFLSAHG 93
Cdd:cd19936     1 IALVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKS-TLPVIFLTSKD 79

                          90
                  ....*....|....*....
gi 2575794190  94 DLDMAVDAMRRGACAFIQK 112
Cdd:cd19936    80 DEIDEVFGLRMGADDYITK 98
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 14-112 3.54e-10

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 55.33  E-value: 3.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLK--GDTPSRPGCLLLDVQMDGMTGLELQEEmIWRGITLPIVFLSA 91
Cdd:cd17584     1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSmlRENKDEFDLVITDVHMPDMDGFEFLEL-IRLEMDLPVIMMSA 79

                          90       100
                  ....*....|....*....|.
gi 2575794190  92 HGDLDMAVDAMRRGACAFIQK 112
Cdd:cd17584    80 DGSTSTVMKGLAHGACDYLLK 100
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 14-112 8.19e-10

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 54.56  E-value: 8.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLEL-----QEEMIWRgitLPIVF 88
Cdd:cd17618     3 ILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFirrlkRDEMTRD---IPIIM 79

                          90       100
                  ....*....|....*....|....
gi 2575794190  89 LSAHGDLDMAVDAMRRGACAFIQK 112
Cdd:cd17618    80 LTARGEEEDKVRGLEAGADDYITK 103
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 14-123 1.14e-09

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 54.15  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHG 93
Cdd:cd17554     3 ILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTAYS 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 2575794190  94 dlDMAVDAMRRGACAFIQKTADRARLLQAI 123
Cdd:cd17554    83 --EYKSDFSSWAADAYVVKSSDLTELKETI 110
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 16-131 1.16e-09

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 55.73  E-value: 1.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPT-AESFLKGDTPSRPGCLLLDVQMDGMTGLELqEEMIWRGITLPIVFLSAHGD 94
Cdd:COG3707     8 VVDDEPLRRADLREGLREAGYEVVAEAAdGEDAVELVRELKPDLVIVDIDMPDRDGLEA-ARQISEERPAPVILLTAYSD 86

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2575794190  95 LDMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKSR 131
Cdd:COG3707    87 PELIERALEAGVSAYLVKPLDPEDLLPALELALARFR 123
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 14-127 5.34e-09

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 52.28  E-value: 5.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFEccVYPTA----ESFLKGDTpSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFL 89
Cdd:cd17542     3 VLIVDDAAFMRMMLKDILTKAGYE--VVGEAangeEAVEKYKE-LKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMC 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2575794190  90 SAHGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAM 127
Cdd:cd17542    80 SAMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKVL 117
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 14-106 1.28e-08

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 51.23  E-value: 1.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHG 93
Cdd:cd17627     1 ILVVDDDRAVRESLRRSLRFEGYEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTARD 80

                          90
                  ....*....|...
gi 2575794190  94 DLDMAVDAMRRGA 106
Cdd:cd17627    81 SVSDRVAGLDAGA 93
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 16-94 1.98e-08

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 50.73  E-value: 1.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLEL--QEEMIWRGITLPIVFLSAHG 93
Cdd:cd19937     2 VVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVcrILRSDPKTSSIPIIMLTAKG 81


                  .
gi 2575794190  94 D 94
Cdd:cd19937    82 E 82
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 16-112 2.26e-08

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 50.81  E-value: 2.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDL 95
Cdd:cd17615     4 VVDDEPNITELLSMALRYEGWDVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLTAKDSV 83

                          90
                  ....*....|....*..
gi 2575794190  96 DMAVDAMRRGACAFIQK 112
Cdd:cd17615    84 EDRIAGLTAGGDDYVTK 100
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
16-195 3.14e-08

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 52.16  E-value: 3.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSR--PGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLS--- 90
Cdd:PRK10403   11 IVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRldPDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTvsd 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  91 AHGDLDMAVDAmrrGACAFIQKTADRARLLQAIvDAMAKSRGAVGDSTPGALV---------AAWNTLTDREKEVAKLVA 161
Cdd:PRK10403   91 ASSDVFALIDA---GADGYLLKDSDPEVLLEAI-RAGAKGSKVFSERVNQYLReremfgaeeDPFSVLTERELDVLHELA 166

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2575794190 162 EGLLNREVGERLgGIAVKTVQVHRSEACSKLGVK 195
Cdd:PRK10403  167 QGLSNKQIASVL-NISEQTVKVHIRNLLRKLNVR 199
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
59-209 8.49e-08

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 50.64  E-value: 8.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  59 LLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMA-------KSR 131
Cdd:PRK09935   53 IIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLSSKSECFYAGRAIQAGANGFVSKCNDQNDIFHAVQMILSgytffpsETL 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2575794190 132 GAVGDSTPGALVAAWNTLTDREKEVAKLVAEGLLNREVGERLgGIAVKTVQVHRSEACSKLGVKGAAGLAQAVRAVEM 209
Cdd:PRK09935  133 NYIKSNKCSTNSSTDTVLSNREVTILRYLVSGLSNKEIADQL-LLSNKTVSAHKSNIYGKLGLHSIVELIDYAKLHEL 209
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
16-195 2.41e-07

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 49.51  E-value: 2.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCV-YPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGD 94
Cdd:PRK09958    5 IIDDHPLAIAAIRNLLIKNDIEILAeLTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKND 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  95 LDMAVDAMRRGACAFIQKTADRARLLQAIvDAMAKSRGAVG---DSTPGALVA---AWNTLTDREKEVAKLVAEGLLNRE 168
Cdd:PRK09958   85 HFYGKHCADAGANGFVSKKEGMNNIIAAI-EAAKNGYCYFPfslNRFVGSLTSdqqKLDSLSKQEISVMRYILDGKDNND 163

                         170       180
                  ....*....|....*....|....*..
gi 2575794190 169 VGERLgGIAVKTVQVHRSEACSKLGVK 195
Cdd:PRK09958  164 IAEKM-FISNKTVSTYKSRLMEKLECK 189
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 14-115 2.98e-07

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 47.55  E-value: 2.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHG 93
Cdd:cd17553     3 ILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYG 82

                          90       100
                  ....*....|....*....|..
gi 2575794190  94 DLDMAVDAMRRGACAFIQKTAD 115
Cdd:cd17553    83 ELDMIQESKELGALTHFAKPFD 104
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 16-125 3.21e-07

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 47.62  E-value: 3.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFML-KHEGFECC-VYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHG 93
Cdd:cd19925     5 IVEDDPMVAEIHRAYVeQVPGFTVIgTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVTAAN 84

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2575794190  94 DLDMAVDAMRRGACAFIQKTADRARLLQAIVD 125
Cdd:cd19925    85 DVETVREALRLGVVDYLIKPFTFERLRQRLER 116
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 16-123 3.22e-07

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 47.53  E-value: 3.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGfECCVYPTAE---SFLKGDTPSRPGCLLLDVQMDGMTGLELQeEMIWRGITLP-IVFLSA 91
Cdd:cd17532     3 IVDDEPLAREELRYLLEEHP-DIEIVGEAEngeEALEAIEELKPDVVFLDIQMPGLDGLELA-KKLSKLAKPPlIVFVTA 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2575794190  92 HGDLdmAVDAMRRGACAFIQKTADRARLLQAI 123
Cdd:cd17532    81 YDEY--AVEAFELNAVDYLLKPFSEERLAEAL 110
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 14-112 6.07e-07

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 46.69  E-value: 6.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEmIWRGITLPIVFLSAHG 93
Cdd:cd17626     3 ILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQ-IRAESGVPIVMLTAKS 81

                          90
                  ....*....|....*....
gi 2575794190  94 DLDMAVDAMRRGACAFIQK 112
Cdd:cd17626    82 DTVDVVLGLESGADDYVAK 100
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 14-112 9.22e-07

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 45.96  E-value: 9.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLE----LQEEMIWRGItlPIVFL 89
Cdd:cd19920     1 ILIVDDVPDNLRLLSELLRAAGYRVLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFEvcrrLKADPATRHI--PVIFL 78

                          90       100
                  ....*....|....*....|...
gi 2575794190  90 SAHGDLDMAVDAMRRGACAFIQK 112
Cdd:cd19920    79 TALTDTEDKVKGFELGAVDYITK 101
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 14-123 1.33e-06

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 45.53  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEM--IWRGITLPIVFLSA 91
Cdd:cd17580     1 ILVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLreLPWLANTPAIALTG 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2575794190  92 HGDLDMAVDAMRRGACAFIQKTADRARLLQAI 123
Cdd:cd17580    81 YGQPEDRERALEAGFDAHLVKPVDPDELIELI 112
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 16-127 1.48e-06

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 45.67  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDL 95
Cdd:cd17625     2 VVEDEKDLSEAITKHLKKEGYTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTALDAV 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2575794190  96 DMAVDAMRRGACAFIQKTADRARLLqAIVDAM 127
Cdd:cd17625    82 EDRVKGLDLGADDYLPKPFSLAELL-ARIRAL 112
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 14-93 1.50e-06

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 45.62  E-value: 1.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHE-GFECCvypTAESFLKG---DTPSRPGCLLLDVQMDGMTGL----ELQEEMIWRGItlP 85
Cdd:cd17552     4 ILVIDDEEDIREVVQACLEKLaGWEVL---TASSGQEGlekAATEQPDAILLDVMMPDMDGLatlkKLQANPETQSI--P 78


                  ....*...
gi 2575794190  86 IVFLSAHG 93
Cdd:cd17552    79 VILLTAKA 86
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 12-128 3.04e-06

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 44.70  E-value: 3.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  12 PLIRIVDDEERMRESLAFMLKHEGFECCvypTAES------FLKgdtpSRPGCLLL-DVQMDGMTGLELQEEMiwRGI-- 82
Cdd:cd17569     1 PTILLVDDEPNILKALKRLLRREGYEVL---TATSgeealeILK----QEPVDVVIsDQRMPGMDGAELLKRV--RERyp 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2575794190  83 -TLPIVfLSAHGDLDMAVDAMRRGAC-AFIQKTADRARLLQAIVDAMA 128
Cdd:cd17569    72 dTVRIL-LTGYADLDAAIEAINEGEIyRFLTKPWDDEELKETIRQALE 118
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 14-112 3.30e-06

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 44.11  E-value: 3.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGiTLPIVFLSAHG 93
Cdd:cd17621     1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARS-NVPVIMVTAKD 79

                          90
                  ....*....|....*....
gi 2575794190  94 DLDMAVDAMRRGACAFIQK 112
Cdd:cd17621    80 SEIDKVVGLELGADDYVTK 98
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 16-65 3.43e-06

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 42.94  E-value: 3.43e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2575794190   16 IVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQM 65
Cdd:smart00448   5 VVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMM 54
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 14-94 4.03e-06

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 44.22  E-value: 4.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEmIWRGITLPIVFLSAHG 93
Cdd:cd17623     1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKE-LRKTSQVPVLMLTARG 79


                  .
gi 2575794190  94 D 94
Cdd:cd17623    80 D 80
PRK09483 PRK09483
response regulator; Provisional
 16-196 4.22e-06

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 45.87  E-value: 4.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHE-GF----ECCVYPTAESFLKGDTPSrpgCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLS 90
Cdd:PRK09483    6 LVDDHELVRAGIRRILEDIkGIkvvgEACCGEDAVKWCRTNAVD---VVLMDMNMPGIGGLEATRKILRYTPDVKIIMLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  91 AHGDLDMAVDAMRRGACAFIQKTADRARLLQAI--VDA------------MAKSRGAVGDSTPgalvaaWNTLTDREKEV 156
Cdd:PRK09483   83 VHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIrsVHSgqryiasdiaqqMALSQIEPATENP------FASLSERELQI 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2575794190 157 AKLVAEGLLNREVGERLgGIAVKTVQVHRSEACSKLGVKG 196
Cdd:PRK09483  157 MLMITKGQKVNEISEQL-NLSPKTVNSYRYRMFSKLNISG 195
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
14-129 5.07e-06

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 45.86  E-value: 5.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGIT--LPIVFLSA 91
Cdd:PRK10161    5 ILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTrdIPVVMLTA 84

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2575794190  92 HGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMAK 129
Cdd:PRK10161   85 RGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRR 122
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 14-106 7.49e-06

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 43.63  E-value: 7.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPT---AESFLKGDTPSrpgCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLS 90
Cdd:cd17624     1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTgaeAEAALASGPYD---LVILDLGLPDGDGLDLLRRWRRQGQSLPVLILT 77

                          90
                  ....*....|....*.
gi 2575794190  91 AHGDLDMAVDAMRRGA 106
Cdd:cd17624    78 ARDGVDDRVAGLDAGA 93
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
14-146 9.73e-06

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 45.41  E-value: 9.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHG 93
Cdd:PRK10365    8 ILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAYS 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2575794190  94 DLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMAKSRGAVGDsTPGALVAAW 146
Cdd:PRK10365   88 SVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHSIDAE-TPAVTASQF 139
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 14-123 1.22e-05

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 42.91  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLE----LQEEMIWRGItlPIVFL 89
Cdd:cd17548     2 ILIVEDNPLNMKLARDLLESAGYEVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEatrlLKEDPATRDI--PVIAL 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2575794190  90 SAH---GDLDMAVDAmrrGACAFIQKTADRARLLQAI 123
Cdd:cd17548    80 TAYamkGDREKILEA---GCDGYISKPIDTREFLETV 113
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 14-112 2.05e-05

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 42.27  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFEccVYpTAESF---LKGDTPSRPGCLLLDVQMDGMTGLELQEEMiwRGI-TLPIVFL 89
Cdd:cd18159     1 ILIVEDDETIASLLKKHLEKWGYE--VV-LIEDFedvLEEFLQFKPDLVLLDINLPYFDGFYWCREI--RQIsNVPIIFI 75

                          90       100
                  ....*....|....*....|....
gi 2575794190  90 SAH-GDLDMaVDAMRRGACAFIQK 112
Cdd:cd18159    76 SSRdDNMDQ-VMAINMGGDDYITK 98
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 16-120 2.22e-05

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 42.43  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECCVyptaeSFlkgdTPSRPGC----------LLLDVQMDGMTGLELQEEMiwRGI--- 82
Cdd:cd17551     5 IVDDNPTNLLLLEALLRSAGYLEVV-----SF----TDPREALawcrenppdlILLDYMMPGMDGLEFIRRL--RALpgl 73

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2575794190  83 -TLPIVFLSAHGDLDMAVDAMRRGACAFIQKTADRARLL 120
Cdd:cd17551    74 eDVPIVMITADTDREVRLRALEAGATDFLTKPFDPVELL 112
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 16-123 2.65e-05

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 42.07  E-value: 2.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFECcvyPTAES------FLKGDTPSrpgCLLLDVQMDGMTGLEL-----QEEMIWRgiTL 84
Cdd:cd17546     3 VVDDNPVNRKVLKKLLEKLGYEV---DVAENgqealeLLKEEPFD---LVLMDLQMPVMDGLEAtrrirELEGGGR--RT 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2575794190  85 PIVFLSAHGDLDMAVDAMRRGACAFIQKTADRARLLQAI 123
Cdd:cd17546    75 PIIALTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 55-112 2.89e-05

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 41.99  E-value: 2.89e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2575794190  55 RPGCLLLDVQMDGMTGLE-LQEEMIWRGItlPIVFLSAH--GDLDMAVDAMRRGACAFIQK 112
Cdd:cd17541    46 KPDVITLDIEMPVMDGLEaLRRIMAERPT--PVVMVSSLteEGAEITLEALELGAVDFIAK 104
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 56-128 2.95e-05

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 41.95  E-value: 2.95e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2575794190  56 PGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMA 128
Cdd:cd19931    45 PDLILLDLNMKGMSGLDTLKALREEGVSARIVILTVSDAEDDVVTALRAGADGYLLKDMEPEDLLEALKQAAS 117
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 14-129 3.17e-05

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 42.02  E-value: 3.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPT-AESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITlPIVFLSAH 92
Cdd:cd19932     3 VLIAEDEALIRMDLREMLEEAGYEVVGEASdGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIA-PIVLLTAY 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2575794190  93 GDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMAK 129
Cdd:cd19932    82 SQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIAR 118
PRK10693 PRK10693
two-component system response regulator RssB;
55-162 4.03e-05

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 43.44  E-value: 4.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  55 RPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDL-DMAvDAMRRGAC-AFIQKTADRARLLQAIVD----AMA 128
Cdd:PRK10693   17 TPDLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVISATENMaDIA-KALRLGVQdVLLKPVKDLNRLREMVFAclypSMF 95

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2575794190 129 KSRgAVGDstpGALVAAWNTLTDREKEVAKLVAE 162
Cdd:PRK10693   96 NSR-VEEE---ERLFRDWDALVDNPAAAAKLLKQ 125
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 14-94 4.44e-05

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 41.59  E-value: 4.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEmIWRGITLPIVFLSAHG 93
Cdd:cd19939     2 ILIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCRE-VREHSHVPILMLTART 80


                  .
gi 2575794190  94 D 94
Cdd:cd19939    81 E 81
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 13-123 5.71e-05

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 41.28  E-value: 5.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  13 LIRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQeEMIWRGITLPIVFLSAH 92
Cdd:cd17594     1 HVLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLL-RTIRARSDVPIIIISGD 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2575794190  93 GDLDMAVD-AMRRGACAFIQKTADRARLLQAI 123
Cdd:cd17594    80 RRDEIDRVvGLELGADDYLAKPFGLRELLARV 111
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 14-127 6.31e-05

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 40.85  E-value: 6.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECC-VYPTAE---SFLKGDTPSrpgcL-LLDVQMDG-MTGLELQEEmIWRGITLPIV 87
Cdd:cd17534     3 ILIVEDEAIIALDLKEILESLGYEVVgIADSGEeaiELAEENKPD----LiLMDINLKGdMDGIEAARE-IREKFDIPVI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2575794190  88 FLSAHGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAM 127
Cdd:cd17534    78 FLTAYSDEETLERAKETNPYGYLVKPFNERELKAAIELAL 117
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 14-112 6.34e-05

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 40.56  E-value: 6.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLEL-----QEEMIWrgiTLPIVF 88
Cdd:cd17538     2 ILVVDDEPANRELLEALLSAEGYEVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVcrrlkEDPETR---HIPVIM 78

                          90       100
                  ....*....|....*....|....
gi 2575794190  89 LSAHGDLDMAVDAMRRGACAFIQK 112
Cdd:cd17538    79 ITALDDREDRIRGLEAGADDFLSK 102
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 14-123 7.11e-05

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 40.75  E-value: 7.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMiwRGIT----LPIVFL 89
Cdd:cd17562     3 ILAVDDSASIRQMVSFTLRGAGYEVVEAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKEL--RKLPaykfTPILML 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2575794190  90 SAHGDLDMAVDAMRRGACAFIQKTADRARLLQAI 123
Cdd:cd17562    81 TTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVV 114
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 12-94 8.02e-05

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 42.26  E-value: 8.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  12 PLIRIVDDEERMRESLAFMLKHEGFeccvypTAESFLKGDTP------SRPGCLLLDVQMDGMTGLELQEEMIWRGITLP 85
Cdd:PRK11083    4 PTILLVEDEQAIADTLVYALQSEGF------TVEWFERGLPAldklrqQPPDLVILDVGLPDISGFELCRQLLAFHPALP 77


                  ....*....
gi 2575794190  86 IVFLSAHGD 94
Cdd:PRK11083   78 VIFLTARSD 86
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 14-106 9.73e-05

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 40.12  E-value: 9.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFEC-CVYPTAESFLKGDTPSRpGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAH 92
Cdd:cd19935     1 ILVVEDEKKLAEYLKKGLTEEGYAVdVAYDGEDGLHLALTNEY-DLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTAR 79

                          90
                  ....*....|....
gi 2575794190  93 GDLDMAVDAMRRGA 106
Cdd:cd19935    80 DSVEDRVKGLDLGA 93
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
159-206 2.08e-04

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 40.46  E-value: 2.08e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2575794190 159 LVAEGLLNREVGERLGgIAVKTVQVHRSEACSKLGVKGAAGLAQAVRA 206
Cdd:COG2909   133 LLAEGLSNKEIAERLF-ISVNTVKTHLRNIYRKLGVRSRTEAVARARE 179
PRK15479 PRK15479
transcriptional regulator TctD;
59-119 2.91e-04

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 40.48  E-value: 2.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2575794190  59 LLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDLDMAVDAMRRGACAFIQKTADRARL 119
Cdd:PRK15479   48 AVLDINMPGMDGLEVLQRLRKRGQTLPVLLLTARSAVADRVKGLNVGADDYLPKPFELEEL 108
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 14-124 3.65e-04

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 38.93  E-value: 3.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHG 93
Cdd:cd17616     1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSGLA 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2575794190  94 DLDMAVDAMRRGACAFIQKTADRARL---LQAIV 124
Cdd:cd17616    81 DIEDKVKGLGFGADDYMTKPFHKDELvarIHAIV 114
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 16-112 4.29e-04

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 38.29  E-value: 4.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEGFEC-CVYPTAESflKGDTPSRPGCLLL-DVQMDGMTGLELQEEMIWRGITLPIVFLSAHG 93
Cdd:cd19926     3 VVDDEPDIRELLEITLGRMGLDVrSARNVKEA--RELLASEPYDLCLtDMRLPDGSGLELVQHIQQRLPQTPVAVITAYG 80

                          90
                  ....*....|....*....
gi 2575794190  94 DLDMAVDAMRRGACAFIQK 112
Cdd:cd19926    81 SLDTAIEALKAGAFDFLTK 99
PRK11697 PRK11697
two-component system response regulator BtsR;
16-119 4.58e-04

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 39.83  E-value: 4.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  16 IVDDEERMRESLAFMLKHEG-----FECcvyPTAESFLKGDTPSRPGCLLLDVQMDGMTGLE----LQEEmiwrgiTLP- 85
Cdd:PRK11697    6 IVDDEPLAREELRELLQEEGdieivGEC---SNAIEAIGAIHRLKPDVVFLDIQMPRISGLElvgmLDPE------HMPy 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2575794190  86 IVFLSAHgDlDMAVDAMRRGACAFIQKTADRARL 119
Cdd:PRK11697   77 IVFVTAF-D-EYAIKAFEEHAFDYLLKPIDPARL 108
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 14-93 4.60e-04

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 38.13  E-value: 4.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFE----CCVyPTAESFLKGDTPSrpgCLLLDVQMDGMTGLELQEEM--IWRGITLPIV 87
Cdd:cd19927     1 ILLVDDDPGIRLAVKDYLEDQGFTviaaSNG-LEALDLLNQYIPD---LIISDIIMPGVDGYSLLGKLrkNADFDTIPVI 76


                  ....*.
gi 2575794190  88 FLSAHG 93
Cdd:cd19927    77 FLTAKG 82
PRK10643 PRK10643
two-component system response regulator PmrA;
14-137 4.90e-04

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 40.02  E-value: 4.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFEC-CV--YPTAESFLKGDTPSrpgCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLS 90
Cdd:PRK10643    3 ILIVEDDTLLLQGLILALQTEGYACdCAstAREAEALLESGHYS---LVVLDLGLPDEDGLHLLRRWRQKKYTLPVLILT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2575794190  91 AHGDLDMAVDAMRRGACAFIQKTADRARlLQAIVDAMAKSRGAVGDS 137
Cdd:PRK10643   80 ARDTLEDRVAGLDVGADDYLVKPFALEE-LHARIRALIRRHQGQGEN 125
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 14-106 6.20e-04

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 37.91  E-value: 6.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMiwRGIT-LPIVFLSAH 92
Cdd:cd17620     1 ILVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRL--REWSaVPVIVLSAR 78

                          90
                  ....*....|....
gi 2575794190  93 GDLDMAVDAMRRGA 106
Cdd:cd17620    79 DEESDKIAALDAGA 92
ompR PRK09468
osmolarity response regulator; Provisional
 7-94 9.26e-04

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 39.19  E-value: 9.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190   7 TTAETPLIRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPI 86
Cdd:PRK09468    1 MMQENYKILVVDDDMRLRALLERYLTEQGFQVRSAANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNNPTPI 80


                  ....*...
gi 2575794190  87 VFLSAHGD 94
Cdd:PRK09468   81 IMLTAKGE 88
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 55-128 1.11e-03

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 37.64  E-value: 1.11e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2575794190  55 RPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHGDLDMAVDAMRRGACAFIQKTADRARLLQAIVDAMA 128
Cdd:cd19930    44 SPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTTFGRPGYFRRALAAGVDGYVLKDRPIEELADAIRTVHA 117
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 89-210 1.13e-03

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 38.66  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  89 LSAHGDLDMAVDAMRRGA-------CAFIQK-----TADRARLLQAIvdamakSRGAVGDstpgalvaawNTLTDREKEV 156
Cdd:PRK10840   95 LSAVLDLDIEGIVLKQGAptdlpkaLAALQKgkkftPESVSRLLEKI------SAGGYGD----------KRLSPKESEV 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2575794190 157 AKLVAEGLLNREVGERLGGiAVKTVQVHRSEACSKLGVKGAAGLAQAVRAVEMA 210
Cdd:PRK10840  159 LRLFAEGFLVTEIAKKLNR-SIKTISSQKKSAMMKLGVENDIALLNYLSSVTLS 211
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 14-91 1.35e-03

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 37.40  E-value: 1.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFEC-CVYPTAESFLKGDTpSRPGCLLLDVQMDGMTGLELQEEmIWRGITLPIVFLSA 91
Cdd:cd17614     1 ILVVDDEKPISDILKFNLTKEGYEVvTAYDGREALEKVEE-EQPDLILLDLMLPEKDGLEVCRE-VRKTSNVPIIMLTA 77
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 14-106 1.46e-03

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 37.26  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTA-ESFLKGDTPSrPGCLLLDVQMDGMTGLELQEEmiWR--GITLPIVFLS 90
Cdd:cd19934     1 LLLVEDDALLAAQLKEQLSDAGYVVDVAEDGeEALFQGEEEP-YDLVVLDLGLPGMDGLSVLRR--WRseGRATPVLILT 77

                          90
                  ....*....|....*.
gi 2575794190  91 AHGDLDMAVDAMRRGA 106
Cdd:cd19934    78 ARDSWQDKVEGLDAGA 93
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 59-123 3.50e-03

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 35.98  E-value: 3.50e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2575794190  59 LLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAhgdlDMAVDAMRR----GACAFIQKTADRARLLQAI 123
Cdd:cd17593    49 LFLDLTMPVMDGYEVLEALPVEQLETKVIVVSG----DVQPEAKERvlelGALAFLKKPFDPEKLAQLL 113
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 14-112 7.97e-03

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 34.79  E-value: 7.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEMIWRGITLPIVFLSAHG 93
Cdd:cd19928     1 ILVADDDRAIRTVLTQALGRAGYEVRTTGNAATLWRWVEEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPIIVMSAQN 80

                          90
                  ....*....|....*....
gi 2575794190  94 DLDMAVDAMRRGACAFIQK 112
Cdd:cd19928    81 TLMTAVKAAERGAFEYLPK 99
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 14-91 9.73e-03

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 34.66  E-value: 9.73e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2575794190  14 IRIVDDEERMRESLAFMLKHEGFECCVYPTAESFLKGDTPSRPGCLLLDVQMDGMTGLELQEEmIWRGITLPIVFLSA 91
Cdd:cd19938     2 ILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCRE-IRRFSDVPIIMVTA 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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