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Conserved domains on  [gi|2579173171|ref|WP_310650656|]
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MULTISPECIES: alpha/beta fold hydrolase [unclassified Colwellia]

Protein Classification

esterase/lipase family protein( domain architecture ID 10787203)

esterase/lipase family protein is an alpha/beta hydrolase, such as triacylglycerol lipase that catalyzes the hydrolysis of a triacylglycerol to form the corresponding diacylglycerol and a carboxylate

CATH:  3.40.50.1820
EC:  3.1.1.-
Gene Ontology:  GO:0016787|GO:0016042
PubMed:  37582413|12369917|19508187|11099800

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 64-160 4.93e-31

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


:

Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 111.46  E-value: 4.93e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2579173171  64 ECVILLHGLARSANSMKAIEKRLLAEGYFVININYPSRDYSIEELAEKV---ISKALLICENRQVNFVTHSMGGILVRQY 140
Cdd:COG1075     6 YPVVLVHGLGGSAASWAPLAPRLRAAGYPVYALNYPSTNGSIEDSAEQLaafVDAVLAATGAEKVDLVGHSMGGLVARYY 85

                          90       100
                  ....*....|....*....|.
gi 2579173171 141 LSMHK-IPNLHKVVMLGPPNN 160
Cdd:COG1075    86 LKRLGgAAKVARVVTLGTPHH 106
 
Name Accession Description Interval E-value
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 64-160 4.93e-31

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 111.46  E-value: 4.93e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2579173171  64 ECVILLHGLARSANSMKAIEKRLLAEGYFVININYPSRDYSIEELAEKV---ISKALLICENRQVNFVTHSMGGILVRQY 140
Cdd:COG1075     6 YPVVLVHGLGGSAASWAPLAPRLRAAGYPVYALNYPSTNGSIEDSAEQLaafVDAVLAATGAEKVDLVGHSMGGLVARYY 85

                          90       100
                  ....*....|....*....|.
gi 2579173171 141 LSMHK-IPNLHKVVMLGPPNN 160
Cdd:COG1075    86 LKRLGgAAKVARVVTLGTPHH 106
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 66-163 7.64e-08

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 52.12  E-value: 7.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2579173171  66 VILLHGLARSANSMKAIEKRLLAEGYFVININYP----------SRDYSIEELAEkVISKALLICENRQVNFVTHSMGGI 135
Cdd:pfam00561   3 VLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRgfgkssrpkaQDDYRTDDLAE-DLEYILEALGLEKVNLVGHSMGGL 81

                          90       100
                  ....*....|....*....|....*...
gi 2579173171 136 LVRQYLSMHKIPnLHKVVMLGPPNNGSE 163
Cdd:pfam00561  82 IALAYAAKYPDR-VKALVLLGALDPPHE 108
PLN02733 PLN02733
phosphatidylcholine-sterol O-acyltransferase
 123-144 7.36e-04

phosphatidylcholine-sterol O-acyltransferase


Pssm-ID: 215390  Cd Length: 440  Bit Score: 40.38  E-value: 7.36e-04
                          10        20
                  ....*....|....*....|..
gi 2579173171 123 RQVNFVTHSMGGILVRQYLSMH 144
Cdd:PLN02733  162 KKVNIISHSMGGLLVKCFMSLH 183
 
Name Accession Description Interval E-value
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 64-160 4.93e-31

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 111.46  E-value: 4.93e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2579173171  64 ECVILLHGLARSANSMKAIEKRLLAEGYFVININYPSRDYSIEELAEKV---ISKALLICENRQVNFVTHSMGGILVRQY 140
Cdd:COG1075     6 YPVVLVHGLGGSAASWAPLAPRLRAAGYPVYALNYPSTNGSIEDSAEQLaafVDAVLAATGAEKVDLVGHSMGGLVARYY 85

                          90       100
                  ....*....|....*....|.
gi 2579173171 141 LSMHK-IPNLHKVVMLGPPNN 160
Cdd:COG1075    86 LKRLGgAAKVARVVTLGTPHH 106
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 66-163 7.64e-08

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 52.12  E-value: 7.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2579173171  66 VILLHGLARSANSMKAIEKRLLAEGYFVININYP----------SRDYSIEELAEkVISKALLICENRQVNFVTHSMGGI 135
Cdd:pfam00561   3 VLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRgfgkssrpkaQDDYRTDDLAE-DLEYILEALGLEKVNLVGHSMGGL 81

                          90       100
                  ....*....|....*....|....*...
gi 2579173171 136 LVRQYLSMHKIPnLHKVVMLGPPNNGSE 163
Cdd:pfam00561  82 IALAYAAKYPDR-VKALVLLGALDPPHE 108
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 62-156 1.02e-07

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 51.16  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2579173171  62 NGECVILLHGLARSANSMKAIEkRLLAEGYFVININY--------PSRDYSIEELAEKVIS--KALLIcenRQVNFVTHS 131
Cdd:COG0596    22 DGPPVVLLHGLPGSSYEWRPLI-PALAAGYRVIAPDLrghgrsdkPAGGYTLDDLADDLAAllDALGL---ERVVLVGHS 97

                          90       100
                  ....*....|....*....|....*.
gi 2579173171 132 MGGILVRQYLSMHkiPN-LHKVVMLG 156
Cdd:COG0596    98 MGGMVALELAARH--PErVAGLVLVD 121
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
66-158 2.51e-05

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 44.55  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2579173171  66 VILLHGLARSANSMKAIEKRLLAEGYFVININYPSRDYSIEEL-----------AEKVISKALLICEnrQVNFVTHSMGG 134
Cdd:COG1647    18 VLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLlkttwedwledVEEAYEILKAGYD--KVIVIGLSMGG 95

                          90       100
                  ....*....|....*....|....
gi 2579173171 135 ILVrQYLSMHKiPNLHKVVMLGPP 158
Cdd:COG1647    96 LLA-LLLAARY-PDVAGLVLLSPA 117
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
66-157 2.41e-04

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 41.14  E-value: 2.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2579173171  66 VILLHGLARSANSMKAIEKRLLAEGYFVININYP---------SRDYSIEELAE--KVISKALLICENRQVNFVTHSMGG 134
Cdd:COG2267    31 VVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRghgrsdgprGHVDSFDDYVDdlRAALDALRARPGLPVVLLGHSMGG 110

                          90       100
                  ....*....|....*....|...
gi 2579173171 135 ILVRQYLSMHKiPNLHKVVMLGP 157
Cdd:COG2267   111 LIALLYAARYP-DRVAGLVLLAP 132
PLN02733 PLN02733
phosphatidylcholine-sterol O-acyltransferase
 123-144 7.36e-04

phosphatidylcholine-sterol O-acyltransferase


Pssm-ID: 215390  Cd Length: 440  Bit Score: 40.38  E-value: 7.36e-04
                          10        20
                  ....*....|....*....|..
gi 2579173171 123 RQVNFVTHSMGGILVRQYLSMH 144
Cdd:PLN02733  162 KKVNIISHSMGGLLVKCFMSLH 183
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 66-158 1.05e-03

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 39.38  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2579173171  66 VILLHGLARSANSMKAiekrLLAEGYFVININYPS------RDYSIEELAEkVISKALLICENRQVNFVTHSMGGILVRQ 139
Cdd:pfam12697   1 VVLVHGAGLSAAPLAA----LLAAGVAVLAPDLPGhgssspPPLDLADLAD-LAALLDELGAARPVVLVGHSLGGAVALA 75

                          90
                  ....*....|....*....
gi 2579173171 140 YLSMHKIpnlhKVVMLGPP 158
Cdd:pfam12697  76 AAAAALV----VGVLVAPL 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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