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Conserved domains on  [gi|2584462131|ref|WP_312507487|]
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DUF2252 family protein [Lysinibacillus sp.]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF2252 super family cl19860
Uncharacterized protein conserved in bacteria (DUF2252); This domain, found in various ...
24-421 1.14e-102

Uncharacterized protein conserved in bacteria (DUF2252); This domain, found in various hypothetical bacterial proteins, has no known function.


The actual alignment was detected with superfamily member COG4320:

Pssm-ID: 473235  Cd Length: 428  Bit Score: 311.80  E-value: 1.14e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131  24 IFEEFDVQRMrlteAQRL-EKYRKMLESPFRFFRGSAYLFYFDMAkttsifHTPNSRP-TWIQGDMHMDNFGAFQNEAGT 101
Cdd:COG4320    25 LLEEQNAGRD----PELLpLKYGRMAASPFAFFRGTAHLFAADLA------GTPNTGPrVWICGDAHLENFGLFASPERL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 102 IVFDVNDFDEGYVGSYLYDIIRMSVSIALYLEEQGLHKATQETAIQYFLNSYIDQLKRFQRkKDDPLTLMFTKDNTKGPA 181
Cdd:COG4320    95 LVFDLNDFDETLPGPWEWDLKRLAASLVLAARENGLSDKEARKLVRAFVRAYREAMARFAG-MDTLDVWRIDADNTRGLV 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 182 KKLLKKLEKRPHSLFLEDIsYKSEDGQRAFLWND-EIQPVSSEEYSAIANALPTY---------------KIKDIAYKHg 245
Cdd:COG4320   174 RKLLEKARRRTRARLLDKL-TEVVDGERRFRDDPpLLVPVSDAERAAVRAALAAYratlppdrrylldryRVKDVARRV- 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 246 SGTASIGLKRYYILVEDKkitSEENDLVLEMKEVRTAIPAYFLPYQEQFWdhyEHQGARVVGTQKAMHHLEDPHLAYITM 325
Cdd:COG4320   252 VGVGSVGTRRYVVLLEGA---DDDDPLILQVKEARPSVLAPYLPPSQPAF---EHEGERVVAGQRLMQAASDPFLGWTTI 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 326 NNQEFYIRERS--PYKKKIKPKNYKDLEDYFTttsLMGKIAAKIHARADIDYShvftYHSEEEILKAIGKDRTiFIEQTI 403
Cdd:COG4320   326 GGRDFYVRQLRpmKGSLDLEDLSPERLEDYAR---LCGRALARAHARSGDDSG----YSIAAAIAGYLGKSDE-FDDAIA 397
                         410
                  ....*....|....*...
gi 2584462131 404 LQAMSYKEMVYTDFDIFK 421
Cdd:COG4320   398 DFALAYADQVERDHAAFV 415
 
Name Accession Description Interval E-value
COG4320 COG4320
Uncharacterized conserved protein, DUF2252 family [Function unknown];
24-421 1.14e-102

Uncharacterized conserved protein, DUF2252 family [Function unknown];


Pssm-ID: 443461  Cd Length: 428  Bit Score: 311.80  E-value: 1.14e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131  24 IFEEFDVQRMrlteAQRL-EKYRKMLESPFRFFRGSAYLFYFDMAkttsifHTPNSRP-TWIQGDMHMDNFGAFQNEAGT 101
Cdd:COG4320    25 LLEEQNAGRD----PELLpLKYGRMAASPFAFFRGTAHLFAADLA------GTPNTGPrVWICGDAHLENFGLFASPERL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 102 IVFDVNDFDEGYVGSYLYDIIRMSVSIALYLEEQGLHKATQETAIQYFLNSYIDQLKRFQRkKDDPLTLMFTKDNTKGPA 181
Cdd:COG4320    95 LVFDLNDFDETLPGPWEWDLKRLAASLVLAARENGLSDKEARKLVRAFVRAYREAMARFAG-MDTLDVWRIDADNTRGLV 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 182 KKLLKKLEKRPHSLFLEDIsYKSEDGQRAFLWND-EIQPVSSEEYSAIANALPTY---------------KIKDIAYKHg 245
Cdd:COG4320   174 RKLLEKARRRTRARLLDKL-TEVVDGERRFRDDPpLLVPVSDAERAAVRAALAAYratlppdrrylldryRVKDVARRV- 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 246 SGTASIGLKRYYILVEDKkitSEENDLVLEMKEVRTAIPAYFLPYQEQFWdhyEHQGARVVGTQKAMHHLEDPHLAYITM 325
Cdd:COG4320   252 VGVGSVGTRRYVVLLEGA---DDDDPLILQVKEARPSVLAPYLPPSQPAF---EHEGERVVAGQRLMQAASDPFLGWTTI 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 326 NNQEFYIRERS--PYKKKIKPKNYKDLEDYFTttsLMGKIAAKIHARADIDYShvftYHSEEEILKAIGKDRTiFIEQTI 403
Cdd:COG4320   326 GGRDFYVRQLRpmKGSLDLEDLSPERLEDYAR---LCGRALARAHARSGDDSG----YSIAAAIAGYLGKSDE-FDDAIA 397
                         410
                  ....*....|....*...
gi 2584462131 404 LQAMSYKEMVYTDFDIFK 421
Cdd:COG4320   398 DFALAYADQVERDHAAFV 415
DUF2252 pfam10009
Uncharacterized protein conserved in bacteria (DUF2252); This domain, found in various ...
34-372 2.76e-67

Uncharacterized protein conserved in bacteria (DUF2252); This domain, found in various hypothetical bacterial proteins, has no known function.


Pssm-ID: 462941  Cd Length: 383  Bit Score: 219.06  E-value: 2.76e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131  34 RLTEAQRLeKYRKMLESPFRFFRGSAYLFYFDMAKTTSifHTPnsrPTWIQGDMHMDNFGAFQNEAGTIVFDVNDFDEGY 113
Cdd:pfam10009   1 RVPELVPL-RYGRMAASPFAFFRGTAALFAADLAATPD--SGP---RVWICGDAHLENFGLYASPEGRLVFDINDFDEAV 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 114 VGSYLYDIIRMSVSIALYLEEQGLHKATQETAIQYFLNSYIDQLKRFqrKKDDPLTL--MFTKDNTKGPAKKLLKKLEKR 191
Cdd:pfam10009  75 VGPFEWDLKRLAASLVLAARENGLSEADARRLVRAAARSYRERMRDY--AGMDPLDEwyAATSETVRGVVRDALRKARRR 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 192 PHSLFLEDISyKSEDGQRAFLWN-DEIQPVSSEEYSAIANALPTY---------------KIKDIAYKHgSGTASIGLKR 255
Cdd:pfam10009 153 TREALLDKLT-EIDGGKRRFRDDpPRLLHLSDDERAAIRAAFESYrdtlpadrrelldrfRLKDVARKV-VGVGSVGTRR 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 256 YYILVEDKkiTSEENDLVLEMKE-VRTAIPAYFLPYQEqfWDHYEHQGARVVGTQKAMHHLEDPHLAYITMNNQEFYIRE 334
Cdd:pfam10009 231 YVVLLEGK--DDDDDPLLLQIKEaRPSVLAPYVGARMP--SSPYRHEGERVVEGQRLLQAASDIFLGWTRLDGRSFYVRQ 306
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2584462131 335 RSPYKKKIKPKN--YKDLEDYFtttSLMGKIAAKIHARAD 372
Cdd:pfam10009 307 LRPMKVSLDLELldKDELQDYA---RLCGRALARAHARSD 343
 
Name Accession Description Interval E-value
COG4320 COG4320
Uncharacterized conserved protein, DUF2252 family [Function unknown];
24-421 1.14e-102

Uncharacterized conserved protein, DUF2252 family [Function unknown];


Pssm-ID: 443461  Cd Length: 428  Bit Score: 311.80  E-value: 1.14e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131  24 IFEEFDVQRMrlteAQRL-EKYRKMLESPFRFFRGSAYLFYFDMAkttsifHTPNSRP-TWIQGDMHMDNFGAFQNEAGT 101
Cdd:COG4320    25 LLEEQNAGRD----PELLpLKYGRMAASPFAFFRGTAHLFAADLA------GTPNTGPrVWICGDAHLENFGLFASPERL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 102 IVFDVNDFDEGYVGSYLYDIIRMSVSIALYLEEQGLHKATQETAIQYFLNSYIDQLKRFQRkKDDPLTLMFTKDNTKGPA 181
Cdd:COG4320    95 LVFDLNDFDETLPGPWEWDLKRLAASLVLAARENGLSDKEARKLVRAFVRAYREAMARFAG-MDTLDVWRIDADNTRGLV 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 182 KKLLKKLEKRPHSLFLEDIsYKSEDGQRAFLWND-EIQPVSSEEYSAIANALPTY---------------KIKDIAYKHg 245
Cdd:COG4320   174 RKLLEKARRRTRARLLDKL-TEVVDGERRFRDDPpLLVPVSDAERAAVRAALAAYratlppdrrylldryRVKDVARRV- 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 246 SGTASIGLKRYYILVEDKkitSEENDLVLEMKEVRTAIPAYFLPYQEQFWdhyEHQGARVVGTQKAMHHLEDPHLAYITM 325
Cdd:COG4320   252 VGVGSVGTRRYVVLLEGA---DDDDPLILQVKEARPSVLAPYLPPSQPAF---EHEGERVVAGQRLMQAASDPFLGWTTI 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 326 NNQEFYIRERS--PYKKKIKPKNYKDLEDYFTttsLMGKIAAKIHARADIDYShvftYHSEEEILKAIGKDRTiFIEQTI 403
Cdd:COG4320   326 GGRDFYVRQLRpmKGSLDLEDLSPERLEDYAR---LCGRALARAHARSGDDSG----YSIAAAIAGYLGKSDE-FDDAIA 397
                         410
                  ....*....|....*...
gi 2584462131 404 LQAMSYKEMVYTDFDIFK 421
Cdd:COG4320   398 DFALAYADQVERDHAAFV 415
DUF2252 pfam10009
Uncharacterized protein conserved in bacteria (DUF2252); This domain, found in various ...
34-372 2.76e-67

Uncharacterized protein conserved in bacteria (DUF2252); This domain, found in various hypothetical bacterial proteins, has no known function.


Pssm-ID: 462941  Cd Length: 383  Bit Score: 219.06  E-value: 2.76e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131  34 RLTEAQRLeKYRKMLESPFRFFRGSAYLFYFDMAKTTSifHTPnsrPTWIQGDMHMDNFGAFQNEAGTIVFDVNDFDEGY 113
Cdd:pfam10009   1 RVPELVPL-RYGRMAASPFAFFRGTAALFAADLAATPD--SGP---RVWICGDAHLENFGLYASPEGRLVFDINDFDEAV 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 114 VGSYLYDIIRMSVSIALYLEEQGLHKATQETAIQYFLNSYIDQLKRFqrKKDDPLTL--MFTKDNTKGPAKKLLKKLEKR 191
Cdd:pfam10009  75 VGPFEWDLKRLAASLVLAARENGLSEADARRLVRAAARSYRERMRDY--AGMDPLDEwyAATSETVRGVVRDALRKARRR 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 192 PHSLFLEDISyKSEDGQRAFLWN-DEIQPVSSEEYSAIANALPTY---------------KIKDIAYKHgSGTASIGLKR 255
Cdd:pfam10009 153 TREALLDKLT-EIDGGKRRFRDDpPRLLHLSDDERAAIRAAFESYrdtlpadrrelldrfRLKDVARKV-VGVGSVGTRR 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2584462131 256 YYILVEDKkiTSEENDLVLEMKE-VRTAIPAYFLPYQEqfWDHYEHQGARVVGTQKAMHHLEDPHLAYITMNNQEFYIRE 334
Cdd:pfam10009 231 YVVLLEGK--DDDDDPLLLQIKEaRPSVLAPYVGARMP--SSPYRHEGERVVEGQRLLQAASDIFLGWTRLDGRSFYVRQ 306
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2584462131 335 RSPYKKKIKPKN--YKDLEDYFtttSLMGKIAAKIHARAD 372
Cdd:pfam10009 307 LRPMKVSLDLELldKDELQDYA---RLCGRALARAHARSD 343
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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