Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  20 RPTILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPETAQIPVVM 98
Cdd:COG3706     1 PARILVVDDDPTNRKLLRRLLEAAgYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADPRTADIPIIF 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2592617773  99 VSGLETELEQKAGFDAGCDAYVVKPFSVKTLIEKIKTLV 137
Cdd:COG3706    81 LTALDDEEDRARALEAGADDYLTKPFDPEELLARVDLVA 119

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  20 RPTILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPETAQIPVVM 98
Cdd:COG3706     1 PARILVVDDDPTNRKLLRRLLEAAgYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADPRTADIPIIF 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2592617773  99 VSGLETELEQKAGFDAGCDAYVVKPFSVKTLIEKIKTLV 137
Cdd:COG3706    81 LTALDDEEDRARALEAGADDYLTKPFDPEELLARVDLVA 119

response regulator PleD; Reviewed

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  22 TILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPETAQIPVVMVS 100
Cdd:PRK09581    4 RILVVDDIPANVKLLEAKLLAEyYTVLTASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLKSDPATTHIPVVMVT 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2592617773 101 GLETELEQKAGFDAGCDAYVVKPFSVKTLIEKIKTLV 137
Cdd:PRK09581   84 ALDDPEDRVRGLEAGADDFLTKPINDVALFARVKSLT 120

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2592617773   21 PTILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMP 74
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEgYEVDEATDGEEALELLKEEKPDLILLDIMMP 55

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  20 RPTILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPETAQIPVVM 98
Cdd:COG3706     1 PARILVVDDDPTNRKLLRRLLEAAgYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADPRTADIPIIF 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2592617773  99 VSGLETELEQKAGFDAGCDAYVVKPFSVKTLIEKIKTLV 137
Cdd:COG3706    81 LTALDDEEDRARALEAGADDYLTKPFDPEELLARVDLVA 119

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  20 RPTILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPetAQIPVVM 98
Cdd:COG0745     1 MPRILVVEDDPDIRELLADALEREgYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARP--SDIPIIM 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2592617773  99 VSGLETELEQKAGFDAGCDAYVVKPFSVKTLIEKIKTLV 137
Cdd:COG0745    79 LTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALL 117

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  22 TILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPETAQIPVVMVS 100
Cdd:cd17538     1 KILVVDDEPANRELLEALLSAEgYEVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKEDPETRHIPVIMIT 80

                          90       100
                  ....*....|....*....|....
gi 2592617773 101 GLETELEQKAGFDAGCDAYVVKPF 124
Cdd:cd17538    81 ALDDREDRIRGLEAGADDFLSKPI 104

response regulator PleD; Reviewed

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  22 TILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPETAQIPVVMVS 100
Cdd:PRK09581    4 RILVVDDIPANVKLLEAKLLAEyYTVLTASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLKSDPATTHIPVVMVT 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2592617773 101 GLETELEQKAGFDAGCDAYVVKPFSVKTLIEKIKTLV 137
Cdd:PRK09581   84 ALDDPEDRVRGLEAGADDFLTKPINDVALFARVKSLT 120

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  24 LVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPETAQIPVVMVSGL 102
Cdd:cd19937     1 LVVDDEEDIVELLKYNLEKEgYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDPKTSSIPIIMLTAK 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2592617773 103 ETELEQKAGFDAGCDAYVVKPFSVKTLIEKIKTL 136
Cdd:cd19937    81 GEEFDKVLGLELGADDYITKPFSPRELLARVKAV 114

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  23 ILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPEtaQIPVVMVSG 101
Cdd:cd17627     1 ILVVDDDRAVRESLRRSLRFEgYEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGN--DLPILVLTA 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2592617773 102 LETELEQKAGFDAGCDAYVVKPFSVKTLIEKIKTLV 137
Cdd:cd17627    79 RDSVSDRVAGLDAGADDYLVKPFALEELLARVRALL 114

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  24 LVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPetAQIPVVMVSGL 102
Cdd:cd00156     1 LIVDDDPAIRELLKSLLEREgYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELP--PDIPVIVLTAK 78

                          90       100
                  ....*....|....*....|.
gi 2592617773 103 ETELEQKAGFDAGCDAYVVKP 123
Cdd:cd00156    79 ADEEDAVRALELGADDYLVKP 99

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  23 ILVVDDEYFN----FEMLKaSLGNEFSLsyANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPET-AQIPVV 97
Cdd:cd17546     1 VLVVDDNPVNrkvlKKLLE-KLGYEVDV--AENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRELEGGgRRTPII 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2592617773  98 MVSGLETELEQKAGFDAGCDAYVVKPFSVKTLIEKI 133
Cdd:cd17546    78 ALTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  23 ILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPetAQIPVVMVSG 101
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEgYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRD--PTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2592617773 102 LETELEQKAGFDAGCDAYVVKPFSVKTLIEKIK 134
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  23 ILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKntpETAQIPVVMVSG 101
Cdd:cd17626     3 ILVVDDDAALAEMIGIVLRGEgFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIR---AESGVPIVMLTA 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2592617773 102 LETELEQKAGFDAGCDAYVVKPFSVKTLIEKIKT 135
Cdd:cd17626    80 KSDTVDVVLGLESGADDYVAKPFKPKELVARIRA 113

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  23 ILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPETaqiPVVMVSG 101
Cdd:cd17614     1 ILVVDDEKPISDILKFNLTKEgYEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNV---PIIMLTA 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2592617773 102 LETELEQKAGFDAGCDAYVVKPFSVKTLIEKIK 134
Cdd:cd17614    78 KDSEVDKVLGLELGADDYVTKPFSNRELLARVK 110

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  23 ILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTcrlLKNTPETAQIPVVMVSG 101
Cdd:cd17623     1 ILLIDDDRELTELLTEYLEMEgFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDV---LKELRKTSQVPVLMLTA 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2592617773 102 LETELEQKAGFDAGCDAYVVKPFSVKTLIEKIK 134
Cdd:cd17623    78 RGDDIDRILGLELGADDYLPKPFNPRELVARIR 110

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  22 TILVVDDEYFNFEMLKASLGNEF---SLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPetAQIPVVM 98
Cdd:COG4753     1 KVLIVDDEPLIREGLKRILEWEAgfeVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELD--PDTKIII 78

                          90       100
                  ....*....|....*....|....*.
gi 2592617773  99 VSGL-ETELEQKAgFDAGCDAYVVKP 123
Cdd:COG4753    79 LSGYsDFEYAQEA-IKLGADDYLLKP 103

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  24 LVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNtpETAQIPVVMVSGL 102
Cdd:cd17625     1 LVVEDEKDLSEAITKHLKKEgYTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLRE--EGIETPVLLLTAL 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2592617773 103 ETELEQKAGFDAGCDAYVVKPFSVKTLIEKIKTLV 137
Cdd:cd17625    79 DAVEDRVKGLDLGADDYLPKPFSLAELLARIRALL 113

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  22 TILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPEtaqIPVVMVS 100
Cdd:cd19938     1 RILIVEDEPKLAQLLIDYLRAAgYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRFSD---VPIIMVT 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2592617773 101 GLETELEQKAGFDAGCDAYVVKPFSVKTLIEKIKTLV 137
Cdd:cd19938    78 ARVEEIDRLLGLELGADDYICKPYSPREVVARVKAIL 114

DNA-binding response regulator CreB; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  19 PRPTILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCR-LLKNTPEtaqIPV 96
Cdd:PRK11083    2 QQPTILLVEDEQAIADTLVYALQSEgFTVEWFERGLPALDKLRQQPPDLVILDVGLPDISGFELCRqLLAFHPA---LPV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2592617773  97 VMVSGLETELEQKAGFDAGCDAYVVKPFSVKTLIEKIKTL 136
Cdd:PRK11083   79 IFLTARSDEVDRLVGLEIGADDYVAKPFSPREVAARVRTI 118

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  23 ILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPETAQIPVVMVSG 101
Cdd:cd17598     1 ILIVEDSPTQAEQLKHILEEQgYKVQVARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKSDPDLKDIPVILLTT 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2592617773 102 LETELEQKAGFDAGCDAYVVKPFSVKTLIEKIKTL 136
Cdd:cd17598    81 LSDPRDVIRGLECGADNFITKPYDEKYLLSRIKYI 115

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  23 ILVVDDEYFNFEMLKASLGN-EFSLSYANSGASCL---------TSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPETA 92
Cdd:cd19924     1 ILVVDDSPTARKQLRDLLKNlGFEIAEAVDGEEALnklenlakeGNDLSKELDLIITDIEMPKMDGYELTFELRDDPRLA 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2592617773  93 QIPVVMVSGLETELEQKAGFDAGCDAYVVKP 123
Cdd:cd19924    81 NIPVILNSSLSGEFSRARGKKVGADAYLAKF 111

DNA-binding transcriptional regulator BaeR; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  21 PTILVVDDE----YFNFEMLKASlgnEFSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPEtaqIPV 96
Cdd:PRK10710   11 PRILIVEDEpklgQLLIDYLQAA---SYATTLLSHGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSD---IPI 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2592617773  97 VMVSGLETELEQKAGFDAGCDAYVVKPFSVKTLIEKIKTL 136
Cdd:PRK10710   85 VMVTAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTI 124

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  23 ILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPETaqIPVVMVSG 101
Cdd:cd19934     1 LLLVEDDALLAAQLKEQLSDAgYVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRA--TPVLILTA 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2592617773 102 LETELEQKAGFDAGCDAYVVKPFSVKTLIEKIKTLV 137
Cdd:cd19934    79 RDSWQDKVEGLDAGADDYLTKPFHIEELLARLRALI 114

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  21 PTILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNtpETAQIPVVMV 99
Cdd:cd17554     1 KKILVVDDEENIRELYKEELEDEgYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIRE--KKPDLPVIIC 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2592617773 100 SGLEtelEQKAGFDAGC-DAYVVKPFSVKTLIEKIKTL 136
Cdd:cd17554    79 TAYS---EYKSDFSSWAaDAYVVKSSDLTELKETIKRL 113

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  22 TILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPETAQIPVVMVS 100
Cdd:cd17562     2 KILAVDDSASIRQMVSFTLRGAgYEVVEAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKLPAYKFTPILMLT 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2592617773 101 gLETELEQKA-GFDAGCDAYVVKPFSVKTLIEKIKTLV 137
Cdd:cd17562    82 -TESSDEKKQeGKAAGATGWLVKPFDPEQLLEVVKKVL 118

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  23 ILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKntpETAQIPVVMVSG 101
Cdd:cd17621     1 VLVVEDEESFSDPLAYLLRKEgFEVTVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLR---ARSNVPVIMVTA 77

                          90       100
                  ....*....|....*....|..
gi 2592617773 102 LETELEQKAGFDAGCDAYVVKP 123
Cdd:cd17621    78 KDSEIDKVVGLELGADDYVTKP 99

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2592617773  23 ILVVDDEYFNFEMLKASLGNE-FSLSYANSGASCLTSAIAEPPDAILLDVCMPGLDGYDTCRLLKNTPETAQIPVVMVSG 101
Cdd:cd17602     1 VACVDDRPSIQKMIEYFLEKQgFRVVVIDDPLRALTTLLNSKPDLILIDIDMPDLDGYELCSLLRKSSALKDTPIIMLTG 80

                          90       100
                  ....*....|....*....|..
gi 2592617773 102 LETELEQKAGFDAGCDAYVVKP 123
Cdd:cd17602    81 KDGLVDRIRAKMAGASGYLTKP 102