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Conserved domains on  [gi|2621016402|ref|WP_318789895|]
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prephenate dehydrogenase/arogenate dehydrogenase family protein [Bifidobacterium longum]

Protein Classification

prephenate dehydrogenase( domain architecture ID 11416637)

prephenate dehydrogenase catalyzes the conversion of prephenate and NAD(+) to 4-hydroxyphenylpyruvate, CO(2) and NADH

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TyrA COG0287
Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is ...
 16-280 1.25e-69

Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


:

Pssm-ID: 440056 [Multi-domain]  Cd Length: 278  Bit Score: 219.23  E-value: 1.25e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  16 SLARRLTERG--VRVVAWNHRPHPYAQAEADGIFCKSTLS-ELMDAEPDVVVLCNPLKAMPAILAALAPLMGdhPNTTLT 92
Cdd:COG0287    15 SLALALKRAGlaHEVVGVDRSPETLERALELGVIDRAATDlEEAVADADLVVLAVPVGATIEVLAELAPHLK--PGAIVT 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  93 DVGSVKGMVRDQVKAAGL-GKCYVGAHPMAGNELSGWQAADPHLYDGALWAITVDESTDYRRFLDVAAMItKDVGNRVIV 171
Cdd:COG0287    93 DVGSVKGAVVEAAEALLPdGVRFVGGHPMAGTEKSGPEAADADLFEGAPYILTPTEGTDPEALERVEELW-EALGARVVE 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402 172 VDDETHDKAAAMISHMPHVVSTALINELVANPDRNIAAALAAGCWRDMTRVSLTDPDRTRAMVEEDSLNVEVLLRRMAAR 251
Cdd:COG0287   172 MDPEEHDRVVAAVSHLPHLLAFALVNTVADLEDEEEILRLAAGGFRDTTRIAASDPEMWRDIFLANREALLEALDRFIEE 251

                         250       260
                  ....*....|....*....|....*....
gi 2621016402 252 LTDMADQLHAGaDGEqDVMGFFAEGDPFR 280
Cdd:COG0287   252 LDALRDALEAG-DGE-ALEELLERARAAR 278
 
Name Accession Description Interval E-value
TyrA COG0287
Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is ...
 16-280 1.25e-69

Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440056 [Multi-domain]  Cd Length: 278  Bit Score: 219.23  E-value: 1.25e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  16 SLARRLTERG--VRVVAWNHRPHPYAQAEADGIFCKSTLS-ELMDAEPDVVVLCNPLKAMPAILAALAPLMGdhPNTTLT 92
Cdd:COG0287    15 SLALALKRAGlaHEVVGVDRSPETLERALELGVIDRAATDlEEAVADADLVVLAVPVGATIEVLAELAPHLK--PGAIVT 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  93 DVGSVKGMVRDQVKAAGL-GKCYVGAHPMAGNELSGWQAADPHLYDGALWAITVDESTDYRRFLDVAAMItKDVGNRVIV 171
Cdd:COG0287    93 DVGSVKGAVVEAAEALLPdGVRFVGGHPMAGTEKSGPEAADADLFEGAPYILTPTEGTDPEALERVEELW-EALGARVVE 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402 172 VDDETHDKAAAMISHMPHVVSTALINELVANPDRNIAAALAAGCWRDMTRVSLTDPDRTRAMVEEDSLNVEVLLRRMAAR 251
Cdd:COG0287   172 MDPEEHDRVVAAVSHLPHLLAFALVNTVADLEDEEEILRLAAGGFRDTTRIAASDPEMWRDIFLANREALLEALDRFIEE 251

                         250       260
                  ....*....|....*....|....*....
gi 2621016402 252 LTDMADQLHAGaDGEqDVMGFFAEGDPFR 280
Cdd:COG0287   252 LDALRDALEAG-DGE-ALEELLERARAAR 278
PRK06545 PRK06545
prephenate dehydrogenase; Validated
 16-281 2.03e-56

prephenate dehydrogenase; Validated


Pssm-ID: 235824 [Multi-domain]  Cd Length: 359  Bit Score: 187.81  E-value: 2.03e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  16 SLARRLTERGVRVVAWNHRPHPYAQAEADGIFCKSTLSELMD---AEPDVVVLCNPLKAMPAILAALApLMGDHPNTTLT 92
Cdd:PRK06545   14 SLALAIKAAGPDVFIIGYDPSAAQLARALGFGVIDELAADLQraaAEADLIVLAVPVDATAALLAELA-DLELKPGVIVT 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  93 DVGSVKGMVRDQVKAA-GLGKCYVGAHPMAGNELSGWQAADPHLYDGALWAITVDESTDYRRFLDVAAMItKDVGNRVIV 171
Cdd:PRK06545   93 DVGSVKGAILAEAEALlGDLIRFVGGHPMAGSHKSGVAAARADLFENAPWVLTPDDHTDPDAVAELKDLL-SGTGAKFVV 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402 172 VDDETHDKAAAMISHMPHVVSTALINELVANPDrnIAAALAAGCWRDMTRVSLTDPDRTRAMVEEDSLNVEVLLRRMAAR 251
Cdd:PRK06545  172 LDAEEHDRAVALVSHLPHILASSLAARLAGEHP--LALRLAAGGFRDITRIASSDPGMWRDILESNAEALLDALDEWIED 249

                         250       260       270
                  ....*....|....*....|....*....|
gi 2621016402 252 LTDMADQLHAGadGEQDVMGFFAEGDPFRR 281
Cdd:PRK06545  250 LDRARDALESG--DAEAIAELFDAGKAGRD 277
PDH_N pfam02153
Prephenate dehydrogenase, nucleotide-binding domain; Members of this family are prephenate ...
 17-171 1.56e-18

Prephenate dehydrogenase, nucleotide-binding domain; Members of this family are prephenate dehydrogenases (PDHs) EC:1.3.1.12 involved in tyrosine biosynthesis. This is the N-terminal nucleotide-binding domain of PDHs, which has a modified Rossmann nucleotide-binding fold with an extended beta-sheet sandwiched by three helices on each face.


Pssm-ID: 460467 [Multi-domain]  Cd Length: 154  Bit Score: 81.28  E-value: 1.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  17 LARRLTERG--VRVVAWNHRPHPYAQAEADG-IFCKSTLSELMDaEPDVVVLCNPLKAMPAILAALAPLMGdhPNTTLTD 93
Cdd:pfam02153   1 LALALRRHGffVTVIGYDINPEAAVAALRLGlGDEATDDIEAVR-EADIVFLAVPVEQTLPVLKELAPHLK--EDALITD 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2621016402  94 VGSVKGMVRDQVKAAGLGKCYVGAHPMAGNELSGWQAADPHLYDGALWAITVDESTDYRRfLDVAAMITKDVGNRVIV 171
Cdd:pfam02153  78 VGSVKVKIIRELEQHLPDKSFVPGHPMAGTEKSGPDAARANLFENAPVILTPTEKTDTEA-LNCVKELLEGVGARVIL 154
 
Name Accession Description Interval E-value
TyrA COG0287
Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is ...
 16-280 1.25e-69

Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440056 [Multi-domain]  Cd Length: 278  Bit Score: 219.23  E-value: 1.25e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  16 SLARRLTERG--VRVVAWNHRPHPYAQAEADGIFCKSTLS-ELMDAEPDVVVLCNPLKAMPAILAALAPLMGdhPNTTLT 92
Cdd:COG0287    15 SLALALKRAGlaHEVVGVDRSPETLERALELGVIDRAATDlEEAVADADLVVLAVPVGATIEVLAELAPHLK--PGAIVT 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  93 DVGSVKGMVRDQVKAAGL-GKCYVGAHPMAGNELSGWQAADPHLYDGALWAITVDESTDYRRFLDVAAMItKDVGNRVIV 171
Cdd:COG0287    93 DVGSVKGAVVEAAEALLPdGVRFVGGHPMAGTEKSGPEAADADLFEGAPYILTPTEGTDPEALERVEELW-EALGARVVE 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402 172 VDDETHDKAAAMISHMPHVVSTALINELVANPDRNIAAALAAGCWRDMTRVSLTDPDRTRAMVEEDSLNVEVLLRRMAAR 251
Cdd:COG0287   172 MDPEEHDRVVAAVSHLPHLLAFALVNTVADLEDEEEILRLAAGGFRDTTRIAASDPEMWRDIFLANREALLEALDRFIEE 251

                         250       260
                  ....*....|....*....|....*....
gi 2621016402 252 LTDMADQLHAGaDGEqDVMGFFAEGDPFR 280
Cdd:COG0287   252 LDALRDALEAG-DGE-ALEELLERARAAR 278
PRK06545 PRK06545
prephenate dehydrogenase; Validated
 16-281 2.03e-56

prephenate dehydrogenase; Validated


Pssm-ID: 235824 [Multi-domain]  Cd Length: 359  Bit Score: 187.81  E-value: 2.03e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  16 SLARRLTERGVRVVAWNHRPHPYAQAEADGIFCKSTLSELMD---AEPDVVVLCNPLKAMPAILAALApLMGDHPNTTLT 92
Cdd:PRK06545   14 SLALAIKAAGPDVFIIGYDPSAAQLARALGFGVIDELAADLQraaAEADLIVLAVPVDATAALLAELA-DLELKPGVIVT 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  93 DVGSVKGMVRDQVKAA-GLGKCYVGAHPMAGNELSGWQAADPHLYDGALWAITVDESTDYRRFLDVAAMItKDVGNRVIV 171
Cdd:PRK06545   93 DVGSVKGAILAEAEALlGDLIRFVGGHPMAGSHKSGVAAARADLFENAPWVLTPDDHTDPDAVAELKDLL-SGTGAKFVV 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402 172 VDDETHDKAAAMISHMPHVVSTALINELVANPDrnIAAALAAGCWRDMTRVSLTDPDRTRAMVEEDSLNVEVLLRRMAAR 251
Cdd:PRK06545  172 LDAEEHDRAVALVSHLPHILASSLAARLAGEHP--LALRLAAGGFRDITRIASSDPGMWRDILESNAEALLDALDEWIED 249

                         250       260       270
                  ....*....|....*....|....*....|
gi 2621016402 252 LTDMADQLHAGadGEQDVMGFFAEGDPFRR 281
Cdd:PRK06545  250 LDRARDALESG--DAEAIAELFDAGKAGRD 277
PRK07417 PRK07417
prephenate/arogenate dehydrogenase;
16-250 1.93e-34

prephenate/arogenate dehydrogenase;


Pssm-ID: 180970 [Multi-domain]  Cd Length: 279  Bit Score: 127.70  E-value: 1.93e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  16 SLARRLTERGVRVVAWNHRPHPYAQAEADGI--FCKSTLSELMDAepDVVVLCNPLKAMPAILAALAPLMgdHPNTTLTD 93
Cdd:PRK07417   14 SLGLDLRSLGHTVYGVSRRESTCERAIERGLvdEASTDLSLLKDC--DLVILALPIGLLLPPSEQLIPAL--PPEAIVTD 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  94 VGSVKGMVrdqVKAAG-LGKCYVGAHPMAGNELSGWQAADPHLYDGALWAITVDESTDyRRFLDVAAMITKDVGNRVIVV 172
Cdd:PRK07417   90 VGSVKAPI---VEAWEkLHPRFVGSHPMAGTAESGVEAGQRGLFKNRPWVLTPTENTD-LNALAIVEELAVSLGSKIYTA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402 173 DDETHDKAAAMISHMPHVVSTALINELVANPD---RNIAAALAAGCWRDMTRVSLTDPDRTRAMVEedsLNVEVLLRRMA 249
Cdd:PRK07417  166 DPEEHDRAVALISHLPVMVSAALIQTCGTEKDpsvLKLAQNLASSGFADTSRVGGGNPELGVMMAE---YNRAALLRSLA 242


                  .
gi 2621016402 250 A 250
Cdd:PRK07417  243 S 243
PRK08507 PRK08507
prephenate dehydrogenase; Validated
 16-227 2.48e-28

prephenate dehydrogenase; Validated


Pssm-ID: 181452 [Multi-domain]  Cd Length: 275  Bit Score: 111.14  E-value: 2.48e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  16 SLARRLTERG--VRVVAWNHRPHPYAQAEADGIFCK-STLSELMDAepDVVVLCNPLKAMPAILAALAPLMgdhPNTTLT 92
Cdd:PRK08507   14 SLGLALKEKGliSKVYGYDHNELHLKKALELGLVDEiVSFEELKKC--DVIFLAIPVDAIIEILPKLLDIK---ENTTII 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  93 DVGSVKGMVRDQVkAAGLGKCYVGAHPMAGNELSGWQAADPHLYDGALWAITVDESTDYRRfLDVAAMITKDVGNRVIVV 172
Cdd:PRK08507   89 DLGSTKAKIIESV-PKHIRKNFIAAHPMAGTENSGPKAAIKGLYEGKVVVLCDVEKSGEKH-QERAKEIFSGLGMRIVYM 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2621016402 173 DDETHDKAAAMISHMPHVVSTALINELVANPD-RNIaAALAAGCWRDMTRVSLTDP 227
Cdd:PRK08507  167 DAKEHDLHAAYISHLPHIISFALANTVLKEEDeRNI-FDLAGGGFRSMSRLAKSSP 221
PRK14806 PRK14806
bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; ...
 14-288 1.63e-27

bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 237820 [Multi-domain]  Cd Length: 735  Bit Score: 113.55  E-value: 1.63e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  14 GGSLARRLTERGV--RVVAWNHRPHPYAQAEADGIF--CKSTLSELMdAEPDVVVLCNPLKAMPAILAALAPLMGDHpnT 89
Cdd:PRK14806   15 GGSFAKALRERGLarEVVAVDRRAKSLELAVSLGVIdrGEEDLAEAV-SGADVIVLAVPVLAMEKVLADLKPLLSEH--A 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  90 TLTDVGSVKGMVRDQVKAA--GLGKCYVGAHPMAGNELSGWQAADPHLYDGALWAITVDESTDyRRFLDVAAMITKDVGN 167
Cdd:PRK14806   92 IVTDVGSTKGNVVDAARAVfgELPAGFVPGHPIAGSEKSGVHAANADLFRNHKVILTPLAETD-PAALARVDRLWRAVGA 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402 168 RVIVVDDETHDKAAAMISHMPHVVSTALINELvANPDRNIAA-ALAAGCWRDMTRVSLTDP----DRTRAmveedslNVE 242
Cdd:PRK14806  171 DVLHMDVAHHDEVLAATSHLPHLLAFSLVDQL-ANREDNLDIfRYAAGGFRDFTRIAASDPvmwhDIFLA-------NKE 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2621016402 243 VLLRRM---AARLTDMADQLHAGaDGEQdVMGFFAegdpfrRYKAAVTH 288
Cdd:PRK14806  243 AVLRALdhfRDDLDALRAAIEAG-DGHA-LLGVFT------RARAAREH 283
PRK07502 PRK07502
prephenate/arogenate dehydrogenase family protein;
15-227 2.00e-21

prephenate/arogenate dehydrogenase family protein;


Pssm-ID: 236034 [Multi-domain]  Cd Length: 307  Bit Score: 93.11  E-value: 2.00e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  15 GSLARRLTERGV--RVVAWNHRPHPYAQAEADGI---FCKSTLSELMDAepDVVVLCNPLKAMPAILAALAPLMgdHPNT 89
Cdd:PRK07502   19 SSLARAIRRLGLagEIVGADRSAETRARARELGLgdrVTTSAAEAVKGA--DLVILCVPVGASGAVAAEIAPHL--KPGA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  90 TLTDVGSVKGMVRDQVKAAGLGKCY-VGAHPMAGNELSGWQAADPHLYDGALWAITVDESTDYRRFLDVAAMITKdVGNR 168
Cdd:PRK07502   95 IVTDVGSVKASVIAAMAPHLPEGVHfIPGHPLAGTEHSGPDAGFAELFENRWCILTPPEGTDPAAVARLTAFWRA-LGAR 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2621016402 169 VIVVDDETHDKAAAMISHMPH-----VVSTALINELVANPDrniAAALAAGCWRDMTRVSLTDP 227
Cdd:PRK07502  174 VEEMDPEHHDLVLAITSHLPHliaytIVGTADDLERVTESE---VIKYSASGFRDFTRIAASDP 234
PDH_N pfam02153
Prephenate dehydrogenase, nucleotide-binding domain; Members of this family are prephenate ...
 17-171 1.56e-18

Prephenate dehydrogenase, nucleotide-binding domain; Members of this family are prephenate dehydrogenases (PDHs) EC:1.3.1.12 involved in tyrosine biosynthesis. This is the N-terminal nucleotide-binding domain of PDHs, which has a modified Rossmann nucleotide-binding fold with an extended beta-sheet sandwiched by three helices on each face.


Pssm-ID: 460467 [Multi-domain]  Cd Length: 154  Bit Score: 81.28  E-value: 1.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  17 LARRLTERG--VRVVAWNHRPHPYAQAEADG-IFCKSTLSELMDaEPDVVVLCNPLKAMPAILAALAPLMGdhPNTTLTD 93
Cdd:pfam02153   1 LALALRRHGffVTVIGYDINPEAAVAALRLGlGDEATDDIEAVR-EADIVFLAVPVEQTLPVLKELAPHLK--EDALITD 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2621016402  94 VGSVKGMVRDQVKAAGLGKCYVGAHPMAGNELSGWQAADPHLYDGALWAITVDESTDYRRfLDVAAMITKDVGNRVIV 171
Cdd:pfam02153  78 VGSVKVKIIRELEQHLPDKSFVPGHPMAGTEKSGPDAARANLFENAPVILTPTEKTDTEA-LNCVKELLEGVGARVIL 154
PRK11861 PRK11861
bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
 63-250 9.78e-14

bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 183343 [Multi-domain]  Cd Length: 673  Bit Score: 72.43  E-value: 9.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  63 VVLCNPLKAMPAILAALAPLMgdHPNTTLTDVGSVKGMVRDQVKAAGLGKC--YVGAHPMAGNELSGWQAADPHLYDGAL 140
Cdd:PRK11861    1 VLLAAPVAQTGPLLARIAPFL--DASTIVTDAGSTKSDVVAAARAALGARIgqFVPGHPIAGRESSGVDAALADLYVGRN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402 141 WAITVDESTDYRRFLDVAAMITKDVGNrVIVVDDETHDKAAAMISHMPHVVSTALINELVANPDRNIAAALAAGCWRDMT 220
Cdd:PRK11861   79 VVLCALPENAPDALARVEAMWRAARAD-VRAMSAEQHDRVFAAVSHLPHVLSFALVEQILGESDAELKFSYAAGGFRDFT 157

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2621016402 221 RVSLTDPDRTR--------AMVEEDSLNVEVLLRRMAA 250
Cdd:PRK11861  158 RIAASSPEMWRdvclanraALLDELDAYTAVLARLRAA 195
PDH_C pfam20463
Prephenate dehydrogenase, dimerization domain; Members of this family are prephenate ...
 173-241 2.74e-09

Prephenate dehydrogenase, dimerization domain; Members of this family are prephenate dehydrogenases EC:1.3.1.12 (PDHs) involved in tyrosine biosynthesis. This is the C-terminal, helical dimerization domain of PDHs.


Pssm-ID: 466612 [Multi-domain]  Cd Length: 102  Bit Score: 53.93  E-value: 2.74e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402 173 DDETHDKAAAMISHMPHVVSTALINELVA-NPDRNIAAALAAGCWRDMTRVSLTDPDRTRAMVEEDSLNV 241
Cdd:pfam20463   1 SPETHDRVVAVVSHLPHFVAIALAATLAElGVDIKEARKLASGGFRDMTRIAGSNPELWADIQTHNARAV 70
PRK08655 PRK08655
prephenate dehydrogenase; Provisional
 17-179 1.48e-05

prephenate dehydrogenase; Provisional


Pssm-ID: 236326 [Multi-domain]  Cd Length: 437  Bit Score: 46.52  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  17 LARRLTERGVRVVAWNHRPHPYAQAEA--DGIFCKSTLSELMDAepDVVVLCNPLKAMPAILAALAPLMgdHPNTTLTDV 94
Cdd:PRK08655   16 FARFLKEKGFEVIVTGRDPKKGKEVAKelGVEYANDNIDAAKDA--DIVIISVPINVTEDVIKEVAPHV--KEGSLLMDV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  95 GSVKGM-VRDQVKAAGLGKCYVGAHPMAGNELsgwqaadPHLyDGALWAITVDESTDYRRFLDVAAMITKDvGNRVIVVD 173
Cdd:PRK08655   92 TSVKERpVEAMEEYAPEGVEILPTHPMFGPRT-------PSL-KGQVVILTPTEKRSNPWFDKVKNFLEKE-GARVIVTS 162


                  ....*.
gi 2621016402 174 DETHDK 179
Cdd:PRK08655  163 PEEHDR 168
PLN02256 PLN02256
arogenate dehydrogenase
 10-186 1.61e-04

arogenate dehydrogenase


Pssm-ID: 215144 [Multi-domain]  Cd Length: 304  Bit Score: 43.11  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  10 LGLIGGSLARRLTERGVRVVAWNHRPHpYAQAEADGIFCKSTLSELMDAEPDVVVLCNPLKAMPAILAALaPLMGDHPNT 89
Cdd:PLN02256   44 FGNFGQFLAKTFVKQGHTVLATSRSDY-SDIAAELGVSFFRDPDDFCEEHPDVVLLCTSILSTEAVLRSL-PLQRLKRST 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  90 TLTDVGSVKGMVRD---QVKAAGLGkcYVGAHPMAGNElSG---WqAADPHLYDGALWAITVDESTDYRRFLDvaamITK 163
Cdd:PLN02256  122 LFVDVLSVKEFPKNlllQVLPEEFD--ILCTHPMFGPE-SGkggW-AGLPFVYDKVRIGDEGEREARCERFLD----IFE 193

                         170       180
                  ....*....|....*....|....*.
gi 2621016402 164 DVGNRVIVVDDETHDKAAA---MISH 186
Cdd:PLN02256  194 EEGCRMVEMSCEEHDRYAAgsqFITH 219
PLN02712 PLN02712
arogenate dehydrogenase
 17-195 1.92e-03

arogenate dehydrogenase


Pssm-ID: 215382 [Multi-domain]  Cd Length: 667  Bit Score: 39.96  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  17 LARRLTERGVRVVAWNHRPHPYAqAEADGIFCKSTLSELMDAEPDVVVLCNPLKAMPAILAALaPLMGDHPNTTLTDVGS 96
Cdd:PLN02712   67 LAKTLISQGHTVLAHSRSDHSLA-ARSLGVSFFLDPHDLCERHPDVILLCTSIISTENVLKSL-PLQRLKRNTLFVDVLS 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  97 VKGMVRD---QVKAAGLGkcYVGAHPMAGNELS--GWQAADpHLYDGAlwAITVDESTDYR--RFLDVAAMitkdVGNRV 169
Cdd:PLN02712  145 VKEFAKNlllDYLPEDFD--IICSHPMFGPQSAkhGWDGLR-FVYEKV--RIGNEELRVSRckSFLEVFER----EGCKM 215

                         170       180
                  ....*....|....*....|....*.
gi 2621016402 170 IVVDDETHDKAAAMISHMPHVVSTAL 195
Cdd:PLN02712  216 VEMSCTEHDKYAAESQFITHTVGRVL 241
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
11-85 6.65e-03

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 37.81  E-value: 6.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621016402  11 GLIGGSLARRLTERGVRVVAWNHRPHPYAQAEADGIFCKSTLSELMDA--EPDVVVLCNPL-KAMPAILAALAPLM--GD 85
Cdd:PRK09599    9 GRMGGNMARRLLRGGHEVVGYDRNPEAVEALAEEGATGADSLEELVAKlpAPRVVWLMVPAgEITDATIDELAPLLspGD 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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