|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
24-375 |
1.29e-45 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 160.83 E-value: 1.29e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 24 VVYSFLPVYLDKSGFRESHIGILLALGPLMSIILQPFIGILADRS-PYKNTFLILLNAGTLISILLFPLHNGLLHVALAS 102
Cdd:cd17335 15 SLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFgKRKALLLLSLLAAVLFFLSLFFVAQIFWLLLLLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 103 FLLASFQAALISVSEAITLEGLDRIQKPYGPVRLAGTAGYAVVSVIAGFFME-----KDIRSIFYLTAFMAFFSILSAWS 177
Cdd:cd17335 95 ILGAFFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDrsstyKNYTIAFYVFAVLMLLALLLALK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 178 LPRVEGHQSR-TRRVPVTDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAFIGGTSDILGILYFISGISEVPFLLYAD 256
Cdd:cd17335 175 FPFRPKHPEPnENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSS 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 257 QIEKKPGIHKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTI-HGMSMAL 335
Cdd:cd17335 255 RLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLlQGLYFGL 334
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2648298703 336 GRILGSVLGGFLIEAIGLMKALLVIALFSLSAIAMFAAVN 375
Cdd:cd17335 335 GGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQ 374
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
26-359 |
2.02e-33 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 127.75 E-value: 2.02e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 26 YSFLPVYLDKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLIL---LNAGTLISILLFPLHNGLLHVALAS 102
Cdd:pfam12832 19 LPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLasiLAAVLFLSVLFIPISLTFWWLALLV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 103 FLLASFQAALISVSEAITLEGLDRIQKPYGPVRLAGTAGYAVVSVIAGFFME-----KDIRSIFYLTAFMAFFSILSAWS 177
Cdd:pfam12832 99 VLFSFFWNAILPQFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDhysvgLLPSVLFYLFAALMLLSLLLPLA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 178 LPRVEGHQSRTRRVPVTDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAFIGGTSDILGILYFISGISEVPFLLYADQ 257
Cdd:pfam12832 179 PPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGASNTLLGALWALGVVAEIPLFFYAHR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 258 IEKKPGIHKTLAFSMGVVGVRFLLL-FIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTI-HGMSMAL 335
Cdd:pfam12832 259 LLRRFGHRNLLIIALLLTALRWLLYaFFVENPWLVLPIQFLHAISFGLTHAAAIEYVRRIFPGSLQGTGQALySGLYFGL 338
|
330 340
....*....|....*....|....
gi 2648298703 336 GRILGSVLGGFLIEAIGLMKALLV 359
Cdd:pfam12832 339 GGALGSLIGGQLWDLFGARFTFRA 362
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
24-372 |
7.99e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 98.42 E-value: 7.99e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 24 VVYSFLPVYLDKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKnTFLILLNAGTLISILLFPLHNGLLHVALASF 103
Cdd:cd17325 14 IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRK-RLLLLGLLLLAVSTLLFAFATSYWQLLLARF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 104 LLASFQAALISVSEAITLE--GLDRIQKPYGPVRLAGTAGYAVVSVIAGFFMEK-DIRSIFYLTAFMAFFSILSAWSLPR 180
Cdd:cd17325 93 LQGLASAAVWPAAMALIADiaPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAlGYRAPFLVCAALALLALVLALLLLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 181 VEGHQSRTRRVPVTD-------IFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAFIGGTSD-ILGILYFISGISEVPFL 252
Cdd:cd17325 173 EPRPPPNKRAVSAARlrsglrlLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPaQIGLLFGAQGLASALSQ 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 253 LYADQIEKKPGIHKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIHGMS 332
Cdd:cd17325 253 PPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA 332
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2648298703 333 MALGRILGSVLGGFLIEAIGLMKALLVIALFSLSAIAMFA 372
Cdd:cd17325 333 FSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
24-336 |
1.79e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 85.80 E-value: 1.79e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 24 VVYSFLPVYLDKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLnAGTLISILLFPLHNGLLHVALASF 103
Cdd:COG2814 28 IVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL-LLFALGSLLCALAPSLWLLLAARF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 104 LLASFQAALISVSEAITLE--GLDRIQKPYGPVRLAGTAGYAVVSVIAGFFMEK-DIRSIFYLTAFMAFFS-ILSAWSLP 179
Cdd:COG2814 107 LQGLGAGALFPAALALIADlvPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALLAlLLLLRLLP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 180 RVEGHQSRTRRVPVTDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYF-AFIGGTSDILGILYFISGISEVPFLLYADQI 258
Cdd:COG2814 187 ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLqEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2648298703 259 EKKPGIHKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIHGMSMALG 336
Cdd:COG2814 267 ADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
24-369 |
2.65e-17 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 82.66 E-value: 2.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 24 VVYSFLPVYL-DKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTfLILLNAGTLISILLFPLHNGLLHVALAS 102
Cdd:cd17329 17 MVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPV-MLAGLLLRALGFALLGFAHSPWLFAIAL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 103 FLLASFQAALISVSEAI--TLEGLDRIQKPYGPVRLAGTAGYAVVSVIAGFFMEKDIRSIFYLTAFMAFFSILSAWSLPR 180
Cdd:cd17329 96 VLTGFGGGLFEPASEAMiaDVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 181 VEGHQSRTRR-----VPVTDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFA-FIGGTSDILGILYFISGISEVPFLLY 254
Cdd:cd17329 176 ETRPKRRAAEkteilRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVeILGLGESLLGLLLALNALLIVLLQFP 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 255 ADQIEKKPGIHKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIHGMSMA 334
Cdd:cd17329 256 VARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWG 335
|
330 340 350
....*....|....*....|....*....|....*
gi 2648298703 335 LGRILGSVLGGFLIEAIGLMKALLVIALFSLSAIA 369
Cdd:cd17329 336 LGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAA 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
27-371 |
6.72e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 75.32 E-value: 6.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 27 SFLPVYLDKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLnAGTLISILLFPLHNGLLHVALASFLLA 106
Cdd:cd17489 17 PVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGL-LIFALATLLYLLATSVALLLVLRLIHG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 107 SFQAALISVSEAITLE--GLDRIQKPYGPVRLAGTAGYAVVSVIAGFFMEK-DIRSIFYLTAFMAFFSILSAWSLPRV-- 181
Cdd:cd17489 96 IGWGAFTTAAATLVADiiPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHlGFAVLFIVAAVLALLALLLVFLVKDPpp 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 182 EGHQSRTRRVPVTDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAFIGgtSDILGILYFISGISEVPFLLYADQIEKK 261
Cdd:cd17489 176 VAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERG--ISNAGLFFTVYAIALLLSRPFSGKLSDR 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 262 PGIHKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIHGMSMALGRILGS 341
Cdd:cd17489 254 KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGG 333
|
330 340 350
....*....|....*....|....*....|
gi 2648298703 342 VLGGFLIEAIGLMKALLVIALFSLSAIAMF 371
Cdd:cd17489 334 LLLGLVAELFGYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
11-372 |
4.48e-14 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 72.64 E-value: 4.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 11 FMLQSALLWSCVPVVYSFLPVYLDKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLNAGTLISILLFP 90
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIMI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 91 LHNGLLHVALASFLlaSFQAALISVSEAITLEGL---DRIQKPYGPVRLAGTAGYAVVSVIAGFFMEK-DIRSIFYLTAF 166
Cdd:cd17490 81 LFPSPWGLLIARFL--SGIAAATWVSFTVLYASYfppDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHfGMRAPFLLAAL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 167 MAFFSILSAWSL--PRVEGHQSRTRRVPVTDIFKNRELVLLMTFSMVAHM-GISFYQNFFPLYFAFIGGTSDILGILYFI 243
Cdd:cd17490 159 AGVLGFILSLFIkeERREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMiTFSTTFGFTPLIAKQLGASSFQLGLLSII 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 244 SGISEVPF-LLYADQIEKKPGIHKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTY-IVFSFsLAVHINKTVPLEL 321
Cdd:cd17490 239 YLLPNALAsLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTgILFPL-LMSLSIEGVPAEQ 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2648298703 322 RATGQTIHGMSMALGRILGSVLGGFLIEAIGLMKALLVIALFSL-SAIAMFA 372
Cdd:cd17490 318 RSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALlAAILSLA 369
|
|
| MFS_NHS |
cd06177 |
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ... |
32-349 |
5.58e-14 |
|
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340866 [Multi-domain] Cd Length: 386 Bit Score: 72.66 E-value: 5.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 32 YLDKSG-FRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLN-AGTLISILLFPLHNGLLHVALAsFLLASFQ 109
Cdd:cd06177 23 YMGSTLgFTGAQIGAVYSTTGIAAIIMPFFLGIIADRFFAAEKVLAVLHlIGAAALFYAATVTDFSVFFWVM-LLYSLCY 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 110 AALISVSEAITLEGLDRIQKPYGPVRLAGTAGYAVVSVIAGFFMEKDIRSIFYLTAFMAFfsILSAWSL------PRVEG 183
Cdd:cd06177 102 MPTLALTNSIAFSNLEDPVKDFPPIRVWGTIGWIAAGWPVGFLGWEASNLQFYIAAGASL--LLGLYSLtlphtpPKKAG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 184 HQSRTRRVPVTD---IFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAFIGGTSDILGILYFISGISEVPFLLYADQIEK 260
Cdd:cd06177 180 KGVSKRSLLGLDafvLLKNPFFAVFFIFSFLLGAPLQFYYTFANPFLNDFGMIVKNPAGIMSLGQISEILFMLAIPFFLK 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 261 KPGIHKTLAFSMGVVGVRFlLLFIIRSP----VLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQ-TIHGMSMAL 335
Cdd:cd06177 260 RLGIKKVMLIGMLAWVLRF-GLFAYGDPspgvWMLVLSIILHGVCYDFFFVTGYIYVDKKAPKDIRASAQgLFMLMTNGV 338
|
330
....*....|....
gi 2648298703 336 GRILGSVLGGFLIE 349
Cdd:cd06177 339 GALVGSILSGKVVD 352
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
43-365 |
7.18e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 72.26 E-value: 7.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 43 IGILLALGPLMSIILQPFIGILADRSPYKNTFLI--LLNAGTLISILLFPL--HNGLLHVALASFLLASFQAALISVSEA 118
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadLLRALLAAVLALLALlgSLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 119 IT--LEGLDRIQKPYGPVRLAGTAGYAVVSVIAGFFMEK-DIRSIFYLTAFMAFFSILSAWSLPRVEGHQSRTRRVPVTD 195
Cdd:cd06173 116 LLpeLVPKEQLVRANALNSLATQLARIIGPALGGLLVALlGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 196 --------IFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAFIGGTSDI-LGILYFISGISEVPFLLYADQIEKKPGIHK 266
Cdd:cd06173 196 dlreglryLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAgYGLLLAAFGVGALLGALLLGRLSKRRRRGR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 267 TLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIHGMSMALGRILGSVLGGF 346
Cdd:cd06173 276 LLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGL 355
|
330
....*....|....*....
gi 2648298703 347 LIEAIGLMKALLVIALFSL 365
Cdd:cd06173 356 LADALGLSAVFLLAGALLL 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-371 |
2.00e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 67.84 E-value: 2.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 11 FMLQSALLWSCVPVVYSFLPVYLDKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLNAGTLiSILLFP 90
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFAL-GALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 91 LHNGLLHVALASFLLASFQAALISVSEAITLEGLDRIQKP--YGPVRLAGTAGYAVVSVIAGFFMEKDI---RSIFYLTA 165
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGraLGLLQAFGSVGGILGPLLGGILASSLGfgwRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 166 FMAFFSILSAW---------SLPRVEGHQSRTRRVPVTDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFA-FIGGTSD 235
Cdd:cd06174 160 ALALLAAILLLlvvpdppesARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLdLGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 236 ILGILYFISGISEVPFLLYADQI-EKKPGIHKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHIN 314
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLsDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2648298703 315 KTVPLELRATGQTIHGMSMALGRILGSVLGGFLI-EAIGLMKALLVIALFSLSAIAMF 371
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
24-352 |
3.74e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.23 E-value: 3.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 24 VVYSFLPVYL-DKSGFRESHIGILLALGPLMSIILQPFIGILADRSPY---KNTFLILlnAGTLISILLFPL-------- 91
Cdd:COG2211 28 LLSAYLLYFYtDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTrwgRRRPWIL--IGAIPLALSFVLlftapdls 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 92 HNGLLHVALASFLLAS-----FQAALISVSEAITLEGLDRIqKPYGPVRLAGTAGYAVVSVIAG----FFMEKDIRSIFY 162
Cdd:COG2211 106 PTGKLIYALVTYLLLGlaytlVNIPYSALGAELTPDYEERT-RLSSWRFAFAGLGGLLASVLPPplvaAFGGDAALGYRL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 163 LTAFMAFFSILSAW-------SLPRVEGHQSRTRRVpVTDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAF-IGGTS 234
Cdd:COG2211 185 TALIFAVLGLLAFLltffgtkERPVPEEEKVSLKES-LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSA 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 235 DILGILYFISGISEVPFLLYADQIEKKPGIHKTLAFSMGVVGVRFLLLFIIR--SPVLMYPVMLLNGLTYIVFSFSLAVH 312
Cdd:COG2211 264 ALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAM 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 2648298703 313 INKTVPLELRATGQTIHGMSMA-------LGRILGSVLGGFLIEAIG 352
Cdd:COG2211 344 LADVVDYDEWKTGRRREGLYFGiftfaikLGQALAGALAGLLLALFG 390
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
25-371 |
1.43e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 65.26 E-value: 1.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 25 VYSFLPVYLDKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLNAGTLISILLFPLHNGLLHVALASFL 104
Cdd:cd17370 18 ARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLSALAKPLLALAGSWQLVLLLRIL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 105 LASFQAALISVSEAITLEGLDRIQ--KPYGPVRLAGTAGyAVVSVIAGFFM----EKDIRSIFYLTAFMAFFSILSAWSL 178
Cdd:cd17370 98 ERLGKGIRTPPRDALLADATPPSGrgKAFGLHRALDTLG-AVLGPLLAALLlyllGGNYRTIFLLAAIPALLALLILLFV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 179 PRVEGHQSRTRRVPVTDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAFIGGTSDILGILYF-----ISGISEVPFLL 253
Cdd:cd17370 177 VKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYalfnlVYALAAYPAGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 254 YADQIekkpGIHKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIHGMSM 333
Cdd:cd17370 257 LSDRI----GRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVV 332
|
330 340 350
....*....|....*....|....*....|....*...
gi 2648298703 334 ALGRILGSVLGGFLIEAIGLMKALLVIALFSLSAIAMF 371
Cdd:cd17370 333 GIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
25-371 |
1.59e-11 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 64.88 E-value: 1.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 25 VYSFLPVYL-DKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLNAGTLISILLFPLHNGLLHVALASF 103
Cdd:cd17471 15 VLPYLSLFLtEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 104 LLASFQAALISVSEAITLEGLDRIQKPYGPVR---------LAGTAGYAVVSVIAGFFmekDIRSIFYLTAFMAFFSILS 174
Cdd:cd17471 95 VLLSLGAAAFPQLFALAREYADRSSGRDATLFnsvlraafsLAWVIGPPLAFLLLDVL---GFTGLFLLAALLYLVVALL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 175 AWS-LPRVEGH-QSRTRRVPVTDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFA-FIGGTSDILGILYFISGISEVPF 251
Cdd:cd17471 172 VLFlLPSVKPPaQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTnELGGSESWVGLLFGLAAALEIPI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 252 LLYADQIEKKPGIHKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPlELRATGQTIHGM 331
Cdd:cd17471 252 MLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMP-GQPGLATTLYSN 330
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2648298703 332 SMALGRILGSVLGGFLIEAIGLMKALLVIALFSLSAIAMF 371
Cdd:cd17471 331 ASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLL 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-341 |
1.64e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 64.75 E-value: 1.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 24 VVYSFLPVYLDKS-GFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLnAGTLISILLFPLHNGLLHVALAS 102
Cdd:pfam07690 14 LLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGL-LLFALGLLLLLFASSLWLLLVLR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 103 FLLASFQAALISVSEAITLE--GLDRIQKPYGPVRLAGTAGYAVVSVIAGFFMEK-DIRSIFYLTAFMAFFSILSAW--- 176
Cdd:pfam07690 93 VLQGLGAGALFPAALALIADwfPPEERGRALGLVSAGFGLGAALGPLLGGLLASLfGWRAAFLILAILSLLAAVLLLlpr 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 177 ----SLPRVEGHQSRTRRVPVTDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAFIGGTSDILGILYFISGISEVPFL 252
Cdd:pfam07690 173 pppeSKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGR 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 253 LYADQIEKKPGIHKTLAFSMG---VVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIH 329
Cdd:pfam07690 253 LLLGRLSDRLGRRRRLLLALLlliLAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLY 332
|
330
....*....|..
gi 2648298703 330 GMSMALGRILGS 341
Cdd:pfam07690 333 NTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
21-381 |
1.54e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 59.12 E-value: 1.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 21 CVPVVYSFLPVYLDKS-GFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLnAGTLISILLFPLHNGLLHVA 99
Cdd:COG2223 19 GVWYLWSVLAPPLAEEfGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL-LLLGIGLLLLALAVSYWLLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 100 LASFLLASFQAALISVSEAITLE--GLDRIQKPYGPVRLAGTAGYAVVSVIAGFFMEK-DIRSIFYLTAFMAFFSILSAW 176
Cdd:COG2223 98 LLGLLLGIGGGGSFAVGIALVSKwfPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAfGWRNAFLILGILLLVVAVLAW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 177 SL----PRVEGHQSRTRRVPVTDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAFIGGTSD-----ILGILYFISGIS 247
Cdd:COG2223 178 LFlrdpPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAataglLAALFALLGALG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 248 EVPFLLYADQIekkpGIHKTLAFSMGVVGVR-FLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQ 326
Cdd:COG2223 258 RPLGGWLSDRI----GGRRVLLIVFALMALGlLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVY 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2648298703 327 TIHGMSMALGRILGSVLGGFLIEAIG-LMKALLVIALFSLSAIAMFAAVNTRIGKA 381
Cdd:COG2223 334 GLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| Nuc_H_symport |
pfam03825 |
Nucleoside H+ symporter; |
32-349 |
5.25e-09 |
|
Nucleoside H+ symporter;
Pssm-ID: 461066 [Multi-domain] Cd Length: 399 Bit Score: 57.47 E-value: 5.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 32 YLDKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLNagTLISILLFPLHNGLLHVALASFLLASFQAA 111
Cdd:pfam03825 28 YMFVTGFDGASIGAVYSSLGIAAIFMPALLGIIADRWFSAERVLAVCH--LIGAITLFMAAQVTTFEAFFLVILVNSLAY 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 112 L--ISVSEAITLEGLDRIQKPYGPVRLAGTAGYAVVSV-----IAGFFMEKDIRSIFYLTAFMAFFSILSAWSLPRVEGH 184
Cdd:pfam03825 106 MptLALTNSIAFANLQDPVTDFPPIRVWGTIGWIMASWpfvmwVVSLAGFELSHMQLLIAAGLSALLVLFALTLPHTPAK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 185 QSRTRRVPVT------DIFKNRELVLLMTFSMVAHMGISFYQNFFPLYF-AFIGGTSDILGILYFISGISEVPFLLYADQ 257
Cdd:pfam03825 186 QKANQSWTTLlgldafALLKNKRMAVFFIFSFLLGAELQIYNVFANTFLtSFDKFIVKHASIIMSLGQISEILFMLTLPF 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 258 IEKKPGIHKTLAFSMGVVGVRFLLLFIIRSP-----VLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQ-TIHGM 331
Cdd:pfam03825 266 FLKRFGIKNVMLIGIVAWALRFAFFAYGADPtpfgtALLLLSMIVHGVAYDFFNITGYIFVDKEVPPAIRASAQgLFLLM 345
|
330
....*....|....*...
gi 2648298703 332 SMALGRILGSVLGGFLIE 349
Cdd:pfam03825 346 TNGFGCILGSILSGMVVE 363
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
12-366 |
1.00e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 56.43 E-value: 1.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 12 MLQSALLWSCVPVVYSFLPVYLDKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLnAGTLISILLFPL 91
Cdd:cd17330 5 VFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSL-AGSAVSYVLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 92 HNGLLhVALASFLLASFQAALISVSEAITLEGLDRIQKP--YGPVRLAGTAGYAVVSVIAGFFM-EKDIRSIFYLTAFMA 168
Cdd:cd17330 84 SRNLW-LLFLARFLDGLTGGNVSVAQAYIADITDEEERAkaFGIISAAFGLGFILGPALGGFLStPYGYALPFLVAAALA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 169 FFSILSAWSLPRVeghqsrtrrvpvtdifknreLVLLMTFSMVAHMGISFYQNFFPLY-FAFIGGTSDILGILYFISGIS 247
Cdd:cd17330 163 LLNLVLVLFFLPP--------------------LRRLLLVYFLIALAFAGLESVFSLFlKDRFGFSPSQIGLLLALVGIA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 248 E-VPFLLYADQIEKKPGIHKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQ 326
Cdd:cd17330 223 GiLAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQ 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 2648298703 327 TIHGMSMALGRILGSVLGGFLIEAIG------LMKALLVIALFSLS 366
Cdd:cd17330 303 GIIQSLQSLARIIGPLLAGPLYSFLGpgvpflLAAGLLLIALFLLS 348
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
136-371 |
1.41e-07 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 52.99 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 136 LAGTAGYAVVSVIAGFFmekDIRSIFYLTAFMAFFSILSAWSL---PRVEGHQSRTRRVPVTDIFKNRELVLLMTFSMVA 212
Cdd:cd17472 130 IAFAISMVLGPLLAAHL---GVSGLFLITAILSLVSLLILLFFvpdPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFIL 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 213 H--MGISFYqnFFPLYFAFIGGTSDILGILY----FISGISEVPFLLYADQIEKKPGIhktLAFSMGVVGVRFLLLFI-I 285
Cdd:cd17472 207 HfvLMAFFY--ILPLLLTQLGGGKGQLWKVYlpaiLIGFILMVPFVIYAEKKGKMKQV---FVSSILLIAVGFLLLLFaA 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 286 RSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIHGMSMALGRILGSVLGGFLIEAIG----LMKALLVIA 361
Cdd:cd17472 282 TSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGyssvFLTILILAL 361
|
250
....*....|
gi 2648298703 362 LFSLSAIAMF 371
Cdd:cd17472 362 LWLLVSFLLP 371
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
37-380 |
5.27e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 5.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 37 GFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLnAGTLISILLFPLHNGLLHVALASFLLASFQAALISVS 116
Cdd:COG2271 41 GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL-LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 117 EAITLE--GLDRIQKPYGPVRLAGTAGYAVVSVIAGFFMEK-DIRSIFYLTAFMAFFsilsaWSLPRVeghqsrtrrvpv 193
Cdd:COG2271 120 LKLIAEwfPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAfGWRAAFLILGLPGLL-----LALLRF------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 194 tdifknrelVLLMTFSMVAHMGISFYQNFFPLYFAFIGGTSD-----ILGILYFISGISEVPFLLYADQIEKKPGIhkTL 268
Cdd:COG2271 183 ---------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLaqaglLLSLPFLAGIVGSLLGGWLSDRLGRRRKL--VL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 269 AFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIHGMSMALGRILGSVLGGFLI 348
Cdd:COG2271 252 AIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL 331
|
330 340 350
....*....|....*....|....*....|..
gi 2648298703 349 EAIGLMKALLVIALFSLSAIAMFAAVNTRIGK 380
Cdd:COG2271 332 DATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
29-372 |
2.01e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.09 E-value: 2.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 29 LPVYLDKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNtFLILLNAGTLISILLFPLHNGLLhVALASFLLASF 108
Cdd:cd17478 19 LPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRY-LLPLGPLLTGLGLSLLGFAPNYW-LLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 109 QAALI--SVSEAITLEGLDRIQKPYGPVRLAGTAGYAVVSVIAGFFMEK-DIRSIFYLTAFMAFFSILSAWSLPRVEGHQ 185
Cdd:cd17478 97 GSAAFhpEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALfGGLGLLILLIIPGLAVALLLLRLRPLKKPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 186 SRTRRVPVTDIFKNRE----LVLLMTFSMVAHMGISFYQNFFPLYFAFIGGT----SDILGILYFISGISEVPFLLYADQ 257
Cdd:cd17478 177 AKKAAAKSSARSTLKGvwraLLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSlvfaGLLLSLFLFAGAIGTLIGGPLSDR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 258 IEKKpgihKTLAFSMGVVGVrFLLLFIIRSPVLMYPVMLLNGLTyIVFSFSLAVhinkTVPLELRATGQ-TIHGMSMALG 336
Cdd:cd17478 257 FGRR----RVIIASLLLAAP-FLLLFLLTPGIWSYILLVLAGFL-LFASFPVTV----VLAQELLPGNVgLASGLMMGLS 326
|
330 340 350
....*....|....*....|....*....|....*....
gi 2648298703 337 RILGSVLG---GFLIEAIGLMKALLVIALFSLSAIAMFA 372
Cdd:cd17478 327 FGLGGIGApvlGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
211-370 |
2.62e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.11 E-value: 2.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 211 VAHMGISFYQNFFPLYFAFIGGTSDILGILYFISGISEVPFLLYADQIEKKPGIHKTLAFSMGVVGVRFLLLFIIRSPVL 290
Cdd:cd17325 7 LDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 291 MYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIHGMSMALGRILGSVLGGFLIEAIGLMKALLVIALFSLSAIAM 370
Cdd:cd17325 87 LLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVL 166
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
40-369 |
6.25e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 47.93 E-value: 6.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 40 ESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLnAGTLISILLFPLHNGLLHVALASFLLASFQAALISVSEAI 119
Cdd:cd17324 33 VAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLL-LLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 120 TLE--GLDRIQKPYGPVRLAGTAGYAVVSVIAGFFMEK-DIRSIFYLTA-FMAFFSILSAWSLPRVEGHQSRTRRV--PV 193
Cdd:cd17324 112 AADlvPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlGWRAAFLAIAvLALLAALLLWRLLPSLPPKKPGSLGLlsSL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 194 TDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAFIGGTSD-ILGILYFISGISEVPFLLYADQIEKKPGIHKTLAFSM 272
Cdd:cd17324 192 LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSsAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 273 GVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPlELRATGQTIHGMSMALGRILGSVLGGFLIEAIG 352
Cdd:cd17324 272 LLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGG 350
|
330
....*....|....*..
gi 2648298703 353 LMKALLVIALFSLSAIA 369
Cdd:cd17324 351 WAGVGWVGAALLLLALL 367
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
25-116 |
8.89e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.17 E-value: 8.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 25 VYSFLPVYLDKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLNAGTLISILLFPLHNGLLHVALASFL 104
Cdd:cd17477 207 FYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFL 286
|
90
....*....|..
gi 2648298703 105 LASFQAALISVS 116
Cdd:cd17477 287 WGGAAGPLYTLA 298
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
205-385 |
9.90e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.20 E-value: 9.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 205 LMTFSMVAHMGISFYQNFFPLYFAFIGGTSDILGILYFISGISEVPFLLYADQIEKKPGIHKTLAFSMGVVGVRFLLLFI 284
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 285 IRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIHGMSMALGRILGSVLGGFLIEAIGLMKALLVIALFS 364
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180
....*....|....*....|.
gi 2648298703 365 LSAIAMFAAVNTRIGKAHTRS 385
Cdd:cd17489 161 LLALLLVFLVKDPPPVAAEEA 181
|
|
| lacY |
PRK09528 |
galactoside permease; Reviewed |
26-228 |
4.59e-05 |
|
galactoside permease; Reviewed
Pssm-ID: 236549 Cd Length: 420 Bit Score: 45.27 E-value: 4.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 26 YSFLPVYL-DKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLnagTLISILLFP----LHNGLLHVAL 100
Cdd:PRK09528 30 FSFFPIWLhDINGLSGTDTGIIFSANSLFALLFQPLYGLISDKLGLKKHLLWII---SGLLVLFGPffiyVFAPLLQYNI 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 101 -------ASFLLASFQAAlISVSEAITlEGLDRIQK-PYGPVRLAGTAGYAVVSVIAGFFMEKDIRSIFYL-TAFMAFFS 171
Cdd:PRK09528 107 llgaivgGIYLGFGFLAG-AGAIEAYI-ERVSRRSGfEYGRARMWGSLGWALCAFIAGILFNINPQINFWLgSGSALILL 184
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2648298703 172 ILSAWSLPRVEGH----------QSRTRRVPVTDIFKNRELVLLMTFSM-VAhmgiSFYQNF---FPLYFA 228
Cdd:PRK09528 185 VLLFFAKPDAPSTakvanalganASAVSLKDALALLKLPKFWFLVLYVIgVA----CFYDVFdqqFPNFFA 251
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
192-374 |
6.13e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 6.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 192 PVTDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAFIGGTSDILGILYFISGISEVPFLLYADQIEKKPGIHKTLAFS 271
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 272 MGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIHGMSMALGRILGSVLGGFLIEAI 351
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180
....*....|....*....|...
gi 2648298703 352 GLMKALLVIALFSLSAIAMFAAV 374
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRL 184
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
40-381 |
7.79e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.46 E-value: 7.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 40 ESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLnAGTLISILLFPLHNGLLHVALASFLLASFQAALISVSEAI 119
Cdd:COG0738 42 DAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL-LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 120 TLEgldrIQKPYGPVRL---------AGTAGYAVVSVIAGFFMEKDIRSIFYLTAFMAFFSILSAW--SLPRVEGHQSRT 188
Cdd:COG0738 121 VAA----LGPETAASRLnllhaffslGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLrsKLPEIEEEEEEA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 189 --RRVPVTDIFKNReLVLLMTFSMVAHMGISF-YQNFFPLYFAFIGGTSDILGILYF-ISGISEVPFLLYADQIEKKPGI 264
Cdd:COG0738 197 agSAASLKSLLKNP-RLLLGGLAIFLYVGAEGaIGDWLPLYLKDVLGLSEATAALGLsLFWGGMTIGRFLGGFLLKRFGP 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 265 HKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTY-IVFS--FSLAVHinktVPLELRATGQTIHGMSMALGRILGS 341
Cdd:COG0738 276 VRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLsLMFPtiFSLALD----GLGKRTAAAVSAVLIMGIVGGAIGP 351
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2648298703 342 VLGGFLIEAIGLMKALLVIALFSLSAIAMFAAVNTRIGKA 381
Cdd:COG0738 352 PLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_MFSD6L |
cd17479 |
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ... |
28-353 |
8.61e-05 |
|
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 44.22 E-value: 8.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 28 FLPVYLDKSGFRESHIGILLALGPLMSIILQPFIGILAdRSPYKNTFLILLNAGTLISILLFPLHNGLLhVALASFLLAS 107
Cdd:cd17479 18 FLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLA-KSYRKRRFVILFSLLISLGTYLLYHQIFLL-VLLVIIIWEL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 108 FQAALISVSEAITLEGLDRIQ--KPYGPVRLAGTAGYAVVSVIAGFF--------MEKDIRSIFYLTAFMAF--FSILSA 175
Cdd:cd17479 96 LSAPLEKVADDSLYEYLDFVDatERYGKLKVWSALGAAFGPCGITLLvdnldcflPPKISRILLHFYTYGGFmiLTFLLS 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 176 WSLP---RVEGHQSRTRRVPVTDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAFIGGTSDILGILYFISGISEVPFL 252
Cdd:cd17479 176 FFYPipvPKKEEHSSKVVKGLRLLGGDGRAILYALTVFLVGFVGSTVQNFLFWLMQDKGGSELHMGLSIALALLSEILMS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 253 LYADQIEKKPGIHKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSL-AVHINKTVPLELRATGQTIHGM 331
Cdd:cd17479 256 FFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWWAVnSQVEFLASPGMERSLQLVLRAL 335
|
330 340
....*....|....*....|..
gi 2648298703 332 SMALGRILGSVLGGFLIEAIGL 353
Cdd:cd17479 336 YYGIGFALGSFVSGFIYDRFGL 357
|
|
| MFS_LacY |
cd06172 |
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ... |
26-372 |
1.90e-04 |
|
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340862 [Multi-domain] Cd Length: 389 Bit Score: 42.99 E-value: 1.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 26 YSFLPVYL-DKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLnagTLISILLFP---------LHNGL 95
Cdd:cd06172 19 FSFFPIWLtQINHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKHLLWFI---SGLLVLFGPffifvygplLQSNI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 96 LHVAL--ASFLLASFQAAlISVSEAITLEGLDRIQKPYGPVRLAGTAGYAVVSVIAGFFMEKDIRSIFYLTAFMA--FFS 171
Cdd:cd06172 96 LLGAIvgGIYLGFAFLAG-CGAIESYIERVSRRFNFEYGRARMWGSLGWALAAFFAGILFNINPNINFWLGSGFAliLLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 172 ILSAWSL--PRVEGHQSRTRRVP----VTDIFKNRELVLLMTFSM-VAHMGISFYQNFFPLYFAFIG----GTSdILGIL 240
Cdd:cd06172 175 LLLFAKPedSDTAAAAGANASSVslkdVLELFRMPKFWFFILFVIgVSCFYDVFDQQFPPYFTSLFAtpeqGNR-VFGYL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 241 YFISGISEVPFLLYADQIEKKPGIHKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLE 320
Cdd:cd06172 254 NSAQVFLEAGMMFLAPLIVNRIGAKNGLLLAGTIMAVRIIGSGLATSPLEISILKLLHAFEVPLLLVSIFKYITSHFDTR 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2648298703 321 LRATGQTIhGMSMA--LGRILGSVLGGFLIEAIGLMKALLVIALFSLSA--IAMFA 372
Cdd:cd06172 334 LSATLYLV-GFQFAkqLGAVVLSPLAGNLYDSIGFQQTYLVLGGIVLVFtlISVFT 388
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-122 |
2.10e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 2.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 7 STVVFMLQSALLWSCVPVVYSFLPVYL-DKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLnAGTLIS 85
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLqEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGL-LLLALG 286
|
90 100 110
....*....|....*....|....*....|....*..
gi 2648298703 86 ILLFPLHNGLLHVALASFLLASFQAALISVSEAITLE 122
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE 323
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
27-97 |
2.97e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.61 E-value: 2.97e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2648298703 27 SFLPVYLDKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYK----NTFLILLNAGTLISILLFPLHNGLLH 97
Cdd:cd17313 20 SYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRigrrRPFILVGAPLAALGLILIPNAADIGL 94
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
40-374 |
3.81e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 42.17 E-value: 3.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 40 ESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLnAGTLISILLFPLHNGLLHVALASFLLASFQAALISVSEAI 119
Cdd:cd17474 33 PAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGL-LLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 120 ---TLEGLDRiQKPYGPVRLAGTAGYAVVSVIAGFFMEKDIRSIFYLTAFMAFFSILSAWSLPRVEGHQSRTRRVPVTD- 195
Cdd:cd17474 112 igdLFEGGER-AKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRd 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 196 ---IFKNRELVLLMTFSMVAHMGISFYQNFFPLYFA-FIGGTSDILGILYFISGISEVPF-LLYADQIEKKPGIHKTLAF 270
Cdd:cd17474 191 lkkALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLElLYGISPIIIGLLFAGWSVLLALGsLFVGRLLKKRFGARRILVI 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 271 SMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIHGMSMALGRILGSVLGGFLIEA 350
Cdd:cd17474 271 GLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEI 350
|
330 340
....*....|....*....|....
gi 2648298703 351 IGLMKALLVIALFSLSAIAMFAAV 374
Cdd:cd17474 351 FGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
28-374 |
1.09e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 40.76 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 28 FLPVYLDKSGFRESHIGILLALGPLMSIILQPFIGILADRSPY---KNTFLILLNA-GTLISILLFPLHNGLLHVALASF 103
Cdd:pfam13347 20 LLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTrwgRRRPWLLLSAiILAVSFILLFTPPELGRAPLFIW 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 104 LLASFQAALISVS----------EAITLEGLDRIqKPYGPVRLAGTAGYAVVSVIAG-----FFMEKDIRSIFylTAFMA 168
Cdd:pfam13347 100 LLATYILLRIAYTffeipywslgPELTRDYDERT-SLTSYRSFFSVGGGLLAAALAFplvliLGGTGLERKGY--RIFAL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 169 FFSIL--------SAWSLPRVEGHQSRTRRVP--------VTDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAFIGG 232
Cdd:pfam13347 177 IGAVLmllgviitAAGTKERVSMRSKEDTGQKeagslldmLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 233 TSDILGILYFISGISEVPFLLYADQIEKKPGIHKTLAFSMGVVGVRFLLLFIIR--SPVLMYPVMLLNGLTYIVFSFSLA 310
Cdd:pfam13347 257 NGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGpnNTLLFLVLYIIIGFGYGSSFFLPW 336
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2648298703 311 VHINKTVPLELRATGQTIHGMSMA-------LGRILGSVLGGFLIEAIGLMKALLVIALFSLSAIAMFAAV 374
Cdd:pfam13347 337 SMLADVVDYGELRTGKRREGTFFAmwsfiskLATGVGLGVSGLLLSAFGYNAGDSVQSPQAVTAIRLLYAV 407
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
222-375 |
1.13e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.67 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 222 FFPLYFA-FIGGTSDILGILYFISGISEVPFLLYADQIEKKPGIHKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGL 300
Cdd:cd17329 21 FMAIYLHqQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGF 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2648298703 301 TYIVFSFSLAVHINKTVPLELRATGQTIHGMSMALGRILGSVLGGFLIEAIGLMKALLVIALFSLSAIAMFAAVN 375
Cdd:cd17329 101 GGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLP 175
|
|
| PRK11128 |
PRK11128 |
3-phenylpropionate MFS transporter; |
28-304 |
1.22e-03 |
|
3-phenylpropionate MFS transporter;
Pssm-ID: 236856 [Multi-domain] Cd Length: 382 Bit Score: 40.65 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 28 FLPVYLDKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLNAGTLISILLFPLHNG---LLHVALASFl 104
Cdd:PRK11128 26 FWSVWLKGQGYTPETIGLLLGAGLVARFLGSLLIAPRVKDPSQLIPALRLLALLTLLFAVAFWFGAHsfwLLFVAIGLF- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 105 lASFQAALISVSEAITLEGLDRIQKPYGPVRLAGTAGYAVVSVIAGFFMEK-DIRSIFY----LTAFMAFFSILSAWSLP 179
Cdd:PRK11128 105 -NLFFSPLVPLTDALANTWQKQIGLDYGKVRLWGSIAFVIGSALTGKLVSWfGEQAILWiltaGVASMLLGQLLRPTIMP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 180 R-VEGHQSRTRRVPVTDIFKNR---ELVLLMTFSMVAHMGisfYQNFFPLYFAFIGGTSDILGILYFISGISEVPFLLYA 255
Cdd:PRK11128 184 QgESRQQESAGWPAWKALLKEPtvwRFLLCVSLLQGSHAA---YYGFSAIYWQAAGYSASTIGYLWSLGVVAEVLIFAFS 260
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2648298703 256 DQIEKKPGIHKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGLTYIV 304
Cdd:PRK11128 261 NRLFRRWSARDLLLLSAICGVVRWGLMGSTTALPWLIVIQILHCGTFTV 309
|
|
| mfs |
NF037955 |
MFS transporter; |
28-362 |
1.32e-03 |
|
MFS transporter;
Pssm-ID: 411561 [Multi-domain] Cd Length: 366 Bit Score: 40.41 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 28 FLPVYLDKSGFRESHIGILLALGPLMSII-LQPFIGiLADRSPYKNTFLILLNAGTLISILLFPL--HNGLLHVALASFL 104
Cdd:NF037955 19 FMPVWLEALGLDAGVIGLLLALPIAVRIVaTAPLMS-LIDRGVGARRLLLAGSLGLALTYALMPAaaALGWPLLALLVAL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 105 LASFQAALISVSEAITLEGLDRIQK-PYGPVRLAGTAGYAVVSVIAGFFMEK--DIRSIFYLTAFMAFFSILSAWSLPRV 181
Cdd:NF037955 98 NAVAQAPLVPSIDYLTLAAVRRDPRlDYARIRMSGSVAFLAANLAGGALLGAlgERVAVPLLLTGLALVAALVALASRVR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 182 EgHQSRTRRVPVTDIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAFIGGTSDILGILYFISGISEVPFLLYADQIekk 261
Cdd:NF037955 178 A-AAAPPRPREAGRPRLPRVLWLAIAAGAAIQASHAAIYAFGSIHWRAHGISTAWIGALWAIGVVAEIVLFALLGRL--- 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 262 PGIHKT----LAFSMGVVGVRFL-LLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIHGMSMALG 336
Cdd:NF037955 254 PARWRTpfrlLGLGAAAALVRAIgMALLGGTLAAVVPLQALHGLTFGATQLGAMAAVSAFAPEGARGRAQGTYSAANALA 333
|
330 340 350
....*....|....*....|....*....|.
gi 2648298703 337 RILGSVLGGFLIEAIG-----LMKALLVIAL 362
Cdd:NF037955 334 SASATLASGLAYRAGGplafaLMAPLALIGL 364
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
200-373 |
3.66e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.12 E-value: 3.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 200 RELVLLMTFSMVAHMGISFYQNFFPLYFAFIGG-TSDILGILYFISGISEVPFLLYADQIEKKPGIHKTLAFSMGVVGVR 278
Cdd:cd17316 177 RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGlSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 279 FLLLFIIR--SPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGqtiHGMSMALGRILGSV---LGGFLIEAIGL 353
Cdd:cd17316 257 ALPLFYLLsgSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATG---VGLSYNLGRLGGGGappLIALLLASTGG 333
|
170 180
....*....|....*....|
gi 2648298703 354 MKALLVIALFSLSAIAMFAA 373
Cdd:cd17316 334 TGVPALILALLAIVALIVAL 353
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
29-153 |
3.73e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.10 E-value: 3.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 29 LPVYL-DKSGFRESHIGILLALGPLMSIILQPFIGILADRSPYKNTFLI--LLNAGTLISILLFPLHNGLLHVALASFLL 105
Cdd:cd17503 201 LPLYLqNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAglLLLALGTLLLAFLTPDTSLWLIILPLFIR 280
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 2648298703 106 ASFQAALISVSEAITLEGLDRIQKPYGPV------RLAGTAGYAVVSVIAGFFM 153
Cdd:cd17503 281 GLGMGLVFMPLNTLALNSLPPEQIGDATAlfntirQLGGSIGTALLATLLTNRT 334
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
205-385 |
4.54e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.55 E-value: 4.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 205 LMTFSMVAHMGISFYQNFFPLYFAF-IGGTSDILGILYFISGISEVPFLLYADQIEKKPGIHKTLAFSMGVVGVRFLLLF 283
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEdLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 284 IIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIHGMSMALGRILGSVLGGFLIEAIGLMKALLVIALF 363
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180
....*....|....*....|..
gi 2648298703 364 SLSAIAMFAAVNTRIGKAHTRS 385
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKP 182
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
43-373 |
4.86e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 38.71 E-value: 4.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 43 IGILLALGPLMSIILQPFIGILADRSPYKNTF---LILLNAGTLISILLfplhNGLLHVALASFLLASFQAALISVSEAI 119
Cdd:cd17473 37 VPLLLTLPALFIALFAPLAGWLADRFGRKRLLiagLLLYGIGGVAGLFL----DSLYALLASRALLGIGVAGIMTLATAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 120 TL---EGLDRiQKPYGPVRLAGTAGYAVVSVIAGFFMEKDIRSIFYLTAFMAFFSILSAWSLPRVEGHQSRTRRVPVT-- 194
Cdd:cd17473 113 IGdyfEGEER-AKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAAta 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 195 DIFKNRELVLLMTFSMVAHMGISFYQNFFPLYFAFIGGTSDIL-GILYFISGISEVPFLLYADQIEKKPGIHKTLAFSMG 273
Cdd:cd17473 192 AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALiGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 274 VVGVRFLLLFIIRSPVLMYPVMLLNGLTYIVFSFSLAVHINKTVPLELRATGQTIHGMSMALGRILGSVLGGFLIEAI-G 352
Cdd:cd17473 272 LMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTgG 351
|
330 340
....*....|....*....|..
gi 2648298703 353 LMKALLVIALFSL-SAIAMFAA 373
Cdd:cd17473 352 LSGAFLILGVLALvLAIVLLLL 373
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
41-381 |
4.95e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.60 E-value: 4.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 41 SHIGILLALGPLMSIILQPFIGILADRSPYKNTFLILLNA-GTLISILLFPLHNGLLHVALASFLLAS--FQAALISV-- 115
Cdd:COG2270 52 ALWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLlGVLATAALFFVAPGGLWLGLLLFVLANigFEGSLVFYna 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 116 --SEAITLEGLDRIqkpYGpvrLAGTAGY--AVVSVIAGFFM------------EKDIRSIFYLTA-FMAFFSILSAWSL 178
Cdd:COG2270 132 flPDIATPEEIGRV---SG---LGWALGYlgGVLLLLINLALflkpeafglpdaGEAVRISFLLTAlWWLLFALPLFLFL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 179 PRVEGHQSRTRRVPVTDIFK-----------NRELVLLMTFSMVAHMGISFYQNFFPLYFA-FIGGTSDILGILYFISGI 246
Cdd:COG2270 206 PERPRPGPAPPRGAVRAGFRelrrtlrelrrYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAgVLGFSTTELIVFGLLVQI 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2648298703 247 SEVPFLLYADQIEKKPGIHKTLAFSMGVVGVRFLLLFIIRSPVLMYPVMLLNGL---TYIVFSFSLAVHInktVPLELRA 323
Cdd:COG2270 286 VAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLvmgGIQALSRSLLARL---IPPGREA 362
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2648298703 324 TGQTIHGMSMALGRILGSVLGGFLIEAIGLMK-ALLVIALFSLSAIAMFAAVNTRIGKA 381
Cdd:COG2270 363 EFFGLYALSGKAASFLGPLLFGLVTQLTGSQRlGILSLIVFFVIGLVLLLRVKVPRGRA 421
|
|
| |
