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Conserved domains on  [gi|2666801557|ref|WP_330013559|]
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cyclic nucleotide-binding domain-containing protein [Kandleria vitulina]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10402 super family cl28241
DNA-binding transcriptional activator YeiL; Provisional
 1-212 3.01e-30

DNA-binding transcriptional activator YeiL; Provisional


The actual alignment was detected with superfamily member PRK10402:

Pssm-ID: 236682 [Multi-domain]  Cd Length: 226  Bit Score: 111.36  E-value: 3.01e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666801557   1 MQNYEYllKDILSPDYYQYLDLKEIPKGEHLLLQGQQLTQVYILLKGKVRTTHITSNGSTHLYSISSPLTLIGEVEFMSR 80
Cdd:PRK10402   14 MSESAF--KDCFSFDVSADTELFHFLAREYIVQEGQQPSYLFYLTRGRAKLYATLANGKVSLIDFFAAPCFIGEIELIDK 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666801557  81 QDVQNDVFAMTDCECYVIDVIRYRDVFMKDLVFMTYICTTIANRIHVATQNFSISVNFPVENRLASYMLAVEQGDIVEEN 160
Cdd:PRK10402   92 DHETKAVQAIEECWCLALPMKDCRPLLLNDALFLRKLCKFLSHKNYRNIVSLTQNQSFPLENRLAAFILLTQEGDLYHEK 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2666801557 161 FVEVAQMIGCSYRQLQRVIKHFISLGYIEKVKRSvYHILDRSALEELGEDLY 212
Cdd:PRK10402  172 HTQAAEYLGVSYRHLLYVLAQFIQDGYLKKSKRG-YLIKNRKQLSGLALELK 222
 
Name Accession Description Interval E-value
PRK10402 PRK10402
DNA-binding transcriptional activator YeiL; Provisional
 1-212 3.01e-30

DNA-binding transcriptional activator YeiL; Provisional


Pssm-ID: 236682 [Multi-domain]  Cd Length: 226  Bit Score: 111.36  E-value: 3.01e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666801557   1 MQNYEYllKDILSPDYYQYLDLKEIPKGEHLLLQGQQLTQVYILLKGKVRTTHITSNGSTHLYSISSPLTLIGEVEFMSR 80
Cdd:PRK10402   14 MSESAF--KDCFSFDVSADTELFHFLAREYIVQEGQQPSYLFYLTRGRAKLYATLANGKVSLIDFFAAPCFIGEIELIDK 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666801557  81 QDVQNDVFAMTDCECYVIDVIRYRDVFMKDLVFMTYICTTIANRIHVATQNFSISVNFPVENRLASYMLAVEQGDIVEEN 160
Cdd:PRK10402   92 DHETKAVQAIEECWCLALPMKDCRPLLLNDALFLRKLCKFLSHKNYRNIVSLTQNQSFPLENRLAAFILLTQEGDLYHEK 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2666801557 161 FVEVAQMIGCSYRQLQRVIKHFISLGYIEKVKRSvYHILDRSALEELGEDLY 212
Cdd:PRK10402  172 HTQAAEYLGVSYRHLLYVLAQFIQDGYLKKSKRG-YLIKNRKQLSGLALELK 222
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 18-207 3.06e-25

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 97.75  E-value: 3.06e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666801557  18 QYLDLKEIPKGEHLLLQGQQLTQVYILLKGKVRTTHITSNGSTHLYSISSPLTLIGEVEFMSRQDVQNDVFAMTDCECYV 97
Cdd:COG0664    14 AHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEDGREQILGFLGPGDFFGELSLLGGEPSPATAEALEDSELLR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666801557  98 IDVIRYRDVFMKDLVFMTYICTTIANRIHVATQNFSISVNFPVENRLASY--MLAVEQGDIVEENF--VEVAQMIGCSYR 173
Cdd:COG0664    94 IPREDLEELLERNPELARALLRLLARRLRQLQERLVSLAFLSAEERLARFllELADRLDGRIDLPLtqEEIASYLGLTRE 173

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2666801557 174 QLQRVIKHFISLGYIEKVKRSVyHILDRSALEEL 207
Cdd:COG0664   174 TVSRILKKLEKEGLIELERGRI-TILDREALERL 206
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 41-110 2.02e-10

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 55.31  E-value: 2.02e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666801557  41 VYILLKGKVRTTHITSNGSTHLYSISSPLTLIGEVEFMSRQDVQNDVFAMTDCECYVIDVIRYRDVFMKD 110
Cdd:pfam00027  20 LYIVLSGKVKVYRTLEDGREQILAVLGPGDFFGELALLGGEPRSATVVALTDSELLVIPREDFLELLERD 89
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 41-114 9.59e-08

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 48.86  E-value: 9.59e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2666801557  41 VYILLKGKVRTTHITSNGSTHLYSISSPLTLIGEVEFMSRQDVQNDVFAMTDCECYVIDVIRYRDVFMKDLVFM 114
Cdd:cd00038    38 LYIVLSGSVEVYKLDEDGREQIVGFLGPGDLFGELALLGNGPRSATVRALTDSELLVLPRSDFRRLLQEYPELA 111
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 41-106 2.39e-03

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 36.61  E-value: 2.39e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2666801557   41 VYILLKGKVRTTHITSNGSTHLYSISSPLTLIGEVEFMsRQDVQNDVFAMTDCECYVIDVIRYRDV 106
Cdd:smart00100  38 FYIIVSGEVEVYKVLEDGEEQIVGTLGPGDFFGELALL-TNSRRAASAAAVALELATLLRIDFRDF 102
 
Name Accession Description Interval E-value
PRK10402 PRK10402
DNA-binding transcriptional activator YeiL; Provisional
 1-212 3.01e-30

DNA-binding transcriptional activator YeiL; Provisional


Pssm-ID: 236682 [Multi-domain]  Cd Length: 226  Bit Score: 111.36  E-value: 3.01e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666801557   1 MQNYEYllKDILSPDYYQYLDLKEIPKGEHLLLQGQQLTQVYILLKGKVRTTHITSNGSTHLYSISSPLTLIGEVEFMSR 80
Cdd:PRK10402   14 MSESAF--KDCFSFDVSADTELFHFLAREYIVQEGQQPSYLFYLTRGRAKLYATLANGKVSLIDFFAAPCFIGEIELIDK 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666801557  81 QDVQNDVFAMTDCECYVIDVIRYRDVFMKDLVFMTYICTTIANRIHVATQNFSISVNFPVENRLASYMLAVEQGDIVEEN 160
Cdd:PRK10402   92 DHETKAVQAIEECWCLALPMKDCRPLLLNDALFLRKLCKFLSHKNYRNIVSLTQNQSFPLENRLAAFILLTQEGDLYHEK 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2666801557 161 FVEVAQMIGCSYRQLQRVIKHFISLGYIEKVKRSvYHILDRSALEELGEDLY 212
Cdd:PRK10402  172 HTQAAEYLGVSYRHLLYVLAQFIQDGYLKKSKRG-YLIKNRKQLSGLALELK 222
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 18-207 3.06e-25

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 97.75  E-value: 3.06e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666801557  18 QYLDLKEIPKGEHLLLQGQQLTQVYILLKGKVRTTHITSNGSTHLYSISSPLTLIGEVEFMSRQDVQNDVFAMTDCECYV 97
Cdd:COG0664    14 AHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEDGREQILGFLGPGDFFGELSLLGGEPSPATAEALEDSELLR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666801557  98 IDVIRYRDVFMKDLVFMTYICTTIANRIHVATQNFSISVNFPVENRLASY--MLAVEQGDIVEENF--VEVAQMIGCSYR 173
Cdd:COG0664    94 IPREDLEELLERNPELARALLRLLARRLRQLQERLVSLAFLSAEERLARFllELADRLDGRIDLPLtqEEIASYLGLTRE 173

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2666801557 174 QLQRVIKHFISLGYIEKVKRSVyHILDRSALEEL 207
Cdd:COG0664   174 TVSRILKKLEKEGLIELERGRI-TILDREALERL 206
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 41-110 2.02e-10

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 55.31  E-value: 2.02e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666801557  41 VYILLKGKVRTTHITSNGSTHLYSISSPLTLIGEVEFMSRQDVQNDVFAMTDCECYVIDVIRYRDVFMKD 110
Cdd:pfam00027  20 LYIVLSGKVKVYRTLEDGREQILAVLGPGDFFGELALLGGEPRSATVVALTDSELLVIPREDFLELLERD 89
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 41-114 9.59e-08

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 48.86  E-value: 9.59e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2666801557  41 VYILLKGKVRTTHITSNGSTHLYSISSPLTLIGEVEFMSRQDVQNDVFAMTDCECYVIDVIRYRDVFMKDLVFM 114
Cdd:cd00038    38 LYIVLSGSVEVYKLDEDGREQIVGFLGPGDLFGELALLGNGPRSATVRALTDSELLVLPRSDFRRLLQEYPELA 111
HTH_Crp_2 pfam13545
Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain ...
 143-207 2.45e-04

Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.


Pssm-ID: 463917 [Multi-domain]  Cd Length: 68  Bit Score: 38.21  E-value: 2.45e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666801557 143 RLASY--MLAVEQGDIVEENFV---EVAQMIGCSYRQLQRVIKHFISLGYIEkvkRSVYHILDRSALEEL 207
Cdd:pfam13545   2 RLARFllELAARDGGGRIDLPLtqeDLADLLGTTRETVSRVLSELRREGLIE---RGRITILDPEALEAL 68
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 41-106 2.39e-03

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 36.61  E-value: 2.39e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2666801557   41 VYILLKGKVRTTHITSNGSTHLYSISSPLTLIGEVEFMsRQDVQNDVFAMTDCECYVIDVIRYRDV 106
Cdd:smart00100  38 FYIIVSGEVEVYKVLEDGEEQIVGTLGPGDFFGELALL-TNSRRAASAAAVALELATLLRIDFRDF 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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