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Conserved domains on  [gi|2669191479|ref|WP_330727802|]
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MarR family transcriptional regulator [Burkholderia multivorans]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-115 6.42e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 84.25  E-value: 6.42e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2669191479   1 MDDALRAHGLGATQWYILHQLARVGPTMQRDLVGSLQIERATVSIVVASLVRKGLVEQIPDAVDQRQKMLRLTRAGAALW 80
Cdd:COG1846    27 LDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALL 106

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2669191479  81 HQL-PDLTFIRDVAFSGFSEADIETTVRVLKTATER 115
Cdd:COG1846   107 EEArPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-115 6.42e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 84.25  E-value: 6.42e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2669191479   1 MDDALRAHGLGATQWYILHQLARVGPTMQRDLVGSLQIERATVSIVVASLVRKGLVEQIPDAVDQRQKMLRLTRAGAALW 80
Cdd:COG1846    27 LDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALL 106

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2669191479  81 HQL-PDLTFIRDVAFSGFSEADIETTVRVLKTATER 115
Cdd:COG1846   107 EEArPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
4-102 1.26e-16

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 69.55  E-value: 1.26e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2669191479    4 ALRAHGLGATQWYILHQLARVGPTMQRDLVGSLQIERATVSIVVASLVRKGLVEQIPDAVDQRQKMLRLTRAGAALWHQL 83
Cdd:smart00347   2 ELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQL 81

                           90       100
                   ....*....|....*....|.
gi 2669191479   84 --PDLTFIRDVaFSGFSEADI 102
Cdd:smart00347  82 leARSETLAEL-LAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 8-67 1.73e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 52.59  E-value: 1.73e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2669191479   8 HGLGATQWYILHQLARVGPTMQRDLVGSLQIERATVSIVVASLVRKGLVEQIPDAVDQRQ 67
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HpaR TIGR02337
homoprotocatechuate degradation operon regulator, HpaR; This Helix-Turn-Helix transcriptional ...
 5-83 3.90e-07

homoprotocatechuate degradation operon regulator, HpaR; This Helix-Turn-Helix transcriptional regulator is a member of the MarR family (pfam01047) and is found in association with operons for the degradation of 4-hydroxyphenylacetic acid via homoprotocatechuate.


Pssm-ID: 188209 [Multi-domain]  Cd Length: 118  Bit Score: 45.45  E-value: 3.90e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2669191479   5 LRAHGLGATQWYILHQLARVGPTMQRDLVGSLQIERATVSIVVASLVRKGLVEQIPDAVDQRQKMLRLTRAGAALWHQL 83
Cdd:TIGR02337  21 LAQHGLTEQQWRILRILAEQGSMEFTQLANQACILRPSLTGILARLERDGLVTRLKASNDQRRVYISLTPKGQALYASL 99
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
1-84 4.10e-03

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 34.87  E-value: 4.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2669191479   1 MDDALRAHGLGATQWYILHQLARVGPTMQRDLVGSLQIERATVSIVVASLVRKGLVEQIPDAVDQRQKMLRLTRAGAAL- 79
Cdd:PRK11512   29 LNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAIc 108


                  ....*..
gi 2669191479  80 --WHQLP 84
Cdd:PRK11512  109 eqCHQLV 115
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-115 6.42e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 84.25  E-value: 6.42e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2669191479   1 MDDALRAHGLGATQWYILHQLARVGPTMQRDLVGSLQIERATVSIVVASLVRKGLVEQIPDAVDQRQKMLRLTRAGAALW 80
Cdd:COG1846    27 LDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALL 106

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2669191479  81 HQL-PDLTFIRDVAFSGFSEADIETTVRVLKTATER 115
Cdd:COG1846   107 EEArPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
4-102 1.26e-16

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 69.55  E-value: 1.26e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2669191479    4 ALRAHGLGATQWYILHQLARVGPTMQRDLVGSLQIERATVSIVVASLVRKGLVEQIPDAVDQRQKMLRLTRAGAALWHQL 83
Cdd:smart00347   2 ELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQL 81

                           90       100
                   ....*....|....*....|.
gi 2669191479   84 --PDLTFIRDVaFSGFSEADI 102
Cdd:smart00347  82 leARSETLAEL-LAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 8-67 1.73e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 52.59  E-value: 1.73e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2669191479   8 HGLGATQWYILHQLARVGPTMQRDLVGSLQIERATVSIVVASLVRKGLVEQIPDAVDQRQ 67
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HpaR TIGR02337
homoprotocatechuate degradation operon regulator, HpaR; This Helix-Turn-Helix transcriptional ...
 5-83 3.90e-07

homoprotocatechuate degradation operon regulator, HpaR; This Helix-Turn-Helix transcriptional regulator is a member of the MarR family (pfam01047) and is found in association with operons for the degradation of 4-hydroxyphenylacetic acid via homoprotocatechuate.


Pssm-ID: 188209 [Multi-domain]  Cd Length: 118  Bit Score: 45.45  E-value: 3.90e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2669191479   5 LRAHGLGATQWYILHQLARVGPTMQRDLVGSLQIERATVSIVVASLVRKGLVEQIPDAVDQRQKMLRLTRAGAALWHQL 83
Cdd:TIGR02337  21 LAQHGLTEQQWRILRILAEQGSMEFTQLANQACILRPSLTGILARLERDGLVTRLKASNDQRRVYISLTPKGQALYASL 99
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 10-68 1.75e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 42.15  E-value: 1.75e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2669191479  10 LGATQWYILHQLARVGPTMQRDLVGSLQIERATVSIVVASLVRKGLVEQIPDAVDQRQK 68
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
HTH_27 pfam13463
Winged helix DNA-binding domain;
10-76 5.77e-06

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 41.12  E-value: 5.77e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2669191479  10 LGATQWYILHQLARVGPTM-QRDLVGSLQIERATVSIVVASLVRKGLVEQIPDAVDQRQKMLRLTRAG 76
Cdd:pfam13463   1 LTRLEALILHNIGHRGDPKtLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
17-76 4.40e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 37.49  E-value: 4.40e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2669191479  17 ILHQLARVGPTMQRDLVGSLQIERATVSIVVASLVRKGLVEQIPDavdqrqKMLRLTRAG 76
Cdd:COG1321    15 IYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPY------GGITLTEEG 68
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
1-84 4.10e-03

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 34.87  E-value: 4.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2669191479   1 MDDALRAHGLGATQWYILHQLARVGPTMQRDLVGSLQIERATVSIVVASLVRKGLVEQIPDAVDQRQKMLRLTRAGAAL- 79
Cdd:PRK11512   29 LNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAIc 108


                  ....*..
gi 2669191479  80 --WHQLP 84
Cdd:PRK11512  109 eqCHQLV 115
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 17-57 5.55e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 33.35  E-value: 5.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2669191479  17 ILHQLARVGPTM-QRDLVGSLQIERATVSIVVASLVRKGLVE 57
Cdd:COG2512    20 VLELLRENGGRMtQSEIVKETGWSKSKVSRLLSRLEERGLIE 61
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 10-110 6.98e-03

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 34.21  E-value: 6.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2669191479  10 LGATQWYILHQLARVGPTM-QRDLVGSLQIERAtvsivvaSLVR-------KGLVEQIPDAVDQRQKMLRLTRAGAALWH 81
Cdd:PRK03573   29 LTQTHWVTLHNIHQLPPEQsQIQLAKAIGIEQP-------SLVRtldqleeKGLISRQTCASDRRAKRIKLTEKAEPLIS 101

                          90       100       110
                  ....*....|....*....|....*....|
gi 2669191479  82 QLPD-LTFIRDVAFSGFSEADIETTVRVLK 110
Cdd:PRK03573  102 EVEAvINKTRAEILHGISAEEIEQLITLIA 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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