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Conserved domains on  [gi|2674537960|ref|WP_331718198|]
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DUF2637 domain-containing protein [Streptomyces virginiae]

Protein Classification

DUF2637 domain-containing protein( domain architecture ID 10566916)

DUF2637 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF2637 pfam10935
Protein of unknown function (DUF2637); This family of proteins has no known function.
 58-213 5.94e-24

Protein of unknown function (DUF2637); This family of proteins has no known function.


:

Pssm-ID: 431544  Cd Length: 161  Bit Score: 98.03  E-value: 5.94e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674537960  58 GVAGSVLIGVIGFLLSFDNLTAAGVKWGFGDRASW-FAVGVDASILTFLVVDLILVIFDVRFGLPRFLAHAMTGATVFFN 136
Cdd:pfam10935   3 AVIFVAIVAGIGFALSFAHLRALAQKAGFLAWLAWlIPLTVDGLIVAASLLALAASLRGRAALLLRLLAWLFTALSSWFN 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2674537960 137 ATAHGHPLDHPVRSLAHGLMPVFFVAGIEAGRRLLIKQAALERGRAYDPIPVHRWALAPWATYKLWRRMKLWEMRSY 213
Cdd:pfam10935  83 GSHATDPTGDVVAAALSLAANVAFELVLGAARRRIEERAGLGAARAPPGLRLLRWLVAPVATLGAWRRMDAALARAY 159
PLN03086 super family cl29366
PRLI-interacting factor K; Provisional
 270-322 1.45e-03

PRLI-interacting factor K; Provisional


The actual alignment was detected with superfamily member PLN03086:

Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 41.40  E-value: 1.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2674537960 270 DKMRRAEQERKQKAdaaalQLELDQE-KSEAEAEKQRLLVQG-----EIDALRASVKAD 322
Cdd:PLN03086   10 EKLEREQRERKQRA-----KLKLERErKAKEEAAKQREAIEAaqrsrRLDAIEAQIKAD 63
 
Name Accession Description Interval E-value
DUF2637 pfam10935
Protein of unknown function (DUF2637); This family of proteins has no known function.
 58-213 5.94e-24

Protein of unknown function (DUF2637); This family of proteins has no known function.


Pssm-ID: 431544  Cd Length: 161  Bit Score: 98.03  E-value: 5.94e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674537960  58 GVAGSVLIGVIGFLLSFDNLTAAGVKWGFGDRASW-FAVGVDASILTFLVVDLILVIFDVRFGLPRFLAHAMTGATVFFN 136
Cdd:pfam10935   3 AVIFVAIVAGIGFALSFAHLRALAQKAGFLAWLAWlIPLTVDGLIVAASLLALAASLRGRAALLLRLLAWLFTALSSWFN 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2674537960 137 ATAHGHPLDHPVRSLAHGLMPVFFVAGIEAGRRLLIKQAALERGRAYDPIPVHRWALAPWATYKLWRRMKLWEMRSY 213
Cdd:pfam10935  83 GSHATDPTGDVVAAALSLAANVAFELVLGAARRRIEERAGLGAARAPPGLRLLRWLVAPVATLGAWRRMDAALARAY 159
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 270-322 1.45e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 41.40  E-value: 1.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2674537960 270 DKMRRAEQERKQKAdaaalQLELDQE-KSEAEAEKQRLLVQG-----EIDALRASVKAD 322
Cdd:PLN03086   10 EKLEREQRERKQRA-----KLKLERErKAKEEAAKQREAIEAaqrsrRLDAIEAQIKAD 63
SPFH_prohibitin cd03401
Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model ...
 255-314 2.19e-03

Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model characterizes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of the SPFH (band 7) domain superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. These microdomains, in addition to being stable scaffolds, may also be dynamic units with their own regulatory functions. Prohibitin is a mitochondrial inner-membrane protein which may act as a chaperone for the stabilization of mitochondrial proteins. Human prohibitin forms a hetero-oligomeric complex with Bap-37 (prohibitin 2, an SPFH domain carrying homolog). This complex may protect non-assembled membrane proteins against proteolysis by the m-AAA protease. Prohibitin and Bap-37 yeast homologs have been implicated in yeast longevity and in the maintenance of mitochondrial morphology.


Pssm-ID: 259799 [Multi-domain]  Cd Length: 195  Bit Score: 39.42  E-value: 2.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2674537960 255 MKKFGMSVDEAL----ALPDKMRRAeQERKQKADAAALQLELDQEKSEAEAEKQRLLVQGEIDA 314
Cdd:cd03401   132 LAPFGIIVDDVLitniDFPDEYEKA-IEAKQVAEQEAERAKFELEKAEQEAERKVIEAEGEAEA 194
 
Name Accession Description Interval E-value
DUF2637 pfam10935
Protein of unknown function (DUF2637); This family of proteins has no known function.
 58-213 5.94e-24

Protein of unknown function (DUF2637); This family of proteins has no known function.


Pssm-ID: 431544  Cd Length: 161  Bit Score: 98.03  E-value: 5.94e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674537960  58 GVAGSVLIGVIGFLLSFDNLTAAGVKWGFGDRASW-FAVGVDASILTFLVVDLILVIFDVRFGLPRFLAHAMTGATVFFN 136
Cdd:pfam10935   3 AVIFVAIVAGIGFALSFAHLRALAQKAGFLAWLAWlIPLTVDGLIVAASLLALAASLRGRAALLLRLLAWLFTALSSWFN 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2674537960 137 ATAHGHPLDHPVRSLAHGLMPVFFVAGIEAGRRLLIKQAALERGRAYDPIPVHRWALAPWATYKLWRRMKLWEMRSY 213
Cdd:pfam10935  83 GSHATDPTGDVVAAALSLAANVAFELVLGAARRRIEERAGLGAARAPPGLRLLRWLVAPVATLGAWRRMDAALARAY 159
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 270-322 1.45e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 41.40  E-value: 1.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2674537960 270 DKMRRAEQERKQKAdaaalQLELDQE-KSEAEAEKQRLLVQG-----EIDALRASVKAD 322
Cdd:PLN03086   10 EKLEREQRERKQRA-----KLKLERErKAKEEAAKQREAIEAaqrsrRLDAIEAQIKAD 63
SPFH_prohibitin cd03401
Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model ...
 255-314 2.19e-03

Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model characterizes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of the SPFH (band 7) domain superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. These microdomains, in addition to being stable scaffolds, may also be dynamic units with their own regulatory functions. Prohibitin is a mitochondrial inner-membrane protein which may act as a chaperone for the stabilization of mitochondrial proteins. Human prohibitin forms a hetero-oligomeric complex with Bap-37 (prohibitin 2, an SPFH domain carrying homolog). This complex may protect non-assembled membrane proteins against proteolysis by the m-AAA protease. Prohibitin and Bap-37 yeast homologs have been implicated in yeast longevity and in the maintenance of mitochondrial morphology.


Pssm-ID: 259799 [Multi-domain]  Cd Length: 195  Bit Score: 39.42  E-value: 2.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2674537960 255 MKKFGMSVDEAL----ALPDKMRRAeQERKQKADAAALQLELDQEKSEAEAEKQRLLVQGEIDA 314
Cdd:cd03401   132 LAPFGIIVDDVLitniDFPDEYEKA-IEAKQVAEQEAERAKFELEKAEQEAERKVIEAEGEAEA 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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