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Conserved domains on  [gi|2674786627|ref|WP_331788860|]
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threonine/serine exporter family protein [Streptomyces chrestomyceticus]

Protein Classification

threonine/serine ThrE exporter family protein( domain architecture ID 11459461)

threonine/serine ThrE exporter family protein similar to Escherichia coli succinate transporter subunit YjjP and threonine/serine exporter ThrE, a membrane protein involved in the export of threonine and serine

Gene Ontology:  GO:0022857|GO:0005886|GO:0055085
PubMed:  11514515|12089010
TCDB:  2.A.79

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YjjP COG2966
Uncharacterized membrane protein YjjP, DUF1212 family [Function unknown];
171-572 2.87e-80

Uncharacterized membrane protein YjjP, DUF1212 family [Function unknown];


:

Pssm-ID: 442206 [Multi-domain]  Cd Length: 409  Bit Score: 258.71  E-value: 2.87e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 171 RVLDLTLRIGEILLAGGEGAEDVEAAMFGVAHAYGLERVEPTVTFTLLSISYQPSlvDDPVTASRTVRRRGVDYTRLSAV 250
Cdd:COG2966    10 EVLDLALRAGELLLESGAETYRVEDTMLRIAAALGLDEVEVFVTPTSITVSLEDG--DEPITRVRRVRPRGINLEKLAEV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 251 FRLVDDITSDGITLEEAYRGLAEIRRNRHPFPSWALTVASGLLSGAASMLVGGGPIVFIAAMVGSMLGDRLAWLASSRGL 330
Cdd:COG2966    88 NRLSRDLVAGELDLEEARRRLDEIKRAPPRYPRWLVVLAAGLAAAAFALLFGGGWLDFLVAFLAGALGGLLRRLLARRGL 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 331 PEFYQFVVAAMPPAAIGVALSFSHVAVQASAVITGGLFALIPGRALVAAVQDGLTGYYITASARLLEVGYLIVGIVIGVL 410
Cdd:COG2966   168 NPFFVEALAAFVATLIALLLARLGLGLNPDLIIIGSILPLVPGVPLTNAVRDLIAGDLVSGLARLAEALLIALAIAFGVA 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 411 AALYIGLQLNPEYLYPAAGFASFNDPPVQIAAAMMLALAFCVLLQQERHTVLLATLNGGVAWVVYGALANVSGMNAVPAT 490
Cdd:COG2966   248 LALSLLGLLGLPPLPPPPLLPLPPWLLLLLAAAAAAAAFAVLFAARRRLLLLAAALAAAAAAARLLLLLLGGGGSAAAAA 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 491 AIAAGLVGLFGQLLSRYRYASALPYVTAAIGPLLPGSATYFGLLNFAQGDIGPGVSSLIKAASLALAIAVGVNLGGEVAR 570
Cdd:COG2966   328 AAAVAVGGLLAARRRRRPPPVVLVPAAVLVVPPGGGLYLRLLLLLGGGGAGAAAALLLAAAAAALLAGLLGAALAVLLRR 407

                  ..
gi 2674786627 571 LF 572
Cdd:COG2966   408 LL 409
 
Name Accession Description Interval E-value
YjjP COG2966
Uncharacterized membrane protein YjjP, DUF1212 family [Function unknown];
171-572 2.87e-80

Uncharacterized membrane protein YjjP, DUF1212 family [Function unknown];


Pssm-ID: 442206 [Multi-domain]  Cd Length: 409  Bit Score: 258.71  E-value: 2.87e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 171 RVLDLTLRIGEILLAGGEGAEDVEAAMFGVAHAYGLERVEPTVTFTLLSISYQPSlvDDPVTASRTVRRRGVDYTRLSAV 250
Cdd:COG2966    10 EVLDLALRAGELLLESGAETYRVEDTMLRIAAALGLDEVEVFVTPTSITVSLEDG--DEPITRVRRVRPRGINLEKLAEV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 251 FRLVDDITSDGITLEEAYRGLAEIRRNRHPFPSWALTVASGLLSGAASMLVGGGPIVFIAAMVGSMLGDRLAWLASSRGL 330
Cdd:COG2966    88 NRLSRDLVAGELDLEEARRRLDEIKRAPPRYPRWLVVLAAGLAAAAFALLFGGGWLDFLVAFLAGALGGLLRRLLARRGL 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 331 PEFYQFVVAAMPPAAIGVALSFSHVAVQASAVITGGLFALIPGRALVAAVQDGLTGYYITASARLLEVGYLIVGIVIGVL 410
Cdd:COG2966   168 NPFFVEALAAFVATLIALLLARLGLGLNPDLIIIGSILPLVPGVPLTNAVRDLIAGDLVSGLARLAEALLIALAIAFGVA 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 411 AALYIGLQLNPEYLYPAAGFASFNDPPVQIAAAMMLALAFCVLLQQERHTVLLATLNGGVAWVVYGALANVSGMNAVPAT 490
Cdd:COG2966   248 LALSLLGLLGLPPLPPPPLLPLPPWLLLLLAAAAAAAAFAVLFAARRRLLLLAAALAAAAAAARLLLLLLGGGGSAAAAA 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 491 AIAAGLVGLFGQLLSRYRYASALPYVTAAIGPLLPGSATYFGLLNFAQGDIGPGVSSLIKAASLALAIAVGVNLGGEVAR 570
Cdd:COG2966   328 AAAVAVGGLLAARRRRRPPPVVLVPAAVLVVPPGGGLYLRLLLLLGGGGAGAAAALLLAAAAAALLAGLLGAALAVLLRR 407

                  ..
gi 2674786627 571 LF 572
Cdd:COG2966   408 LL 409
ThrE pfam06738
Putative threonine/serine exporter; ThrE is a family of bacterial and Archaeal proteins that ...
174-416 4.16e-64

Putative threonine/serine exporter; ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.


Pssm-ID: 461997  Cd Length: 241  Bit Score: 210.46  E-value: 4.16e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 174 DLTLRIGEILLAGGEGAEDVEAAMFGVAHAYGLERVEPTVTFTLLSISYQPslVDDPVTASRTVRRRGVDYTRLSAVFRL 253
Cdd:pfam06738   1 DFALRAGRILLESGAETYRVEDTMNRIARALGIDECEVFVTPTGIIISFDD--DDESITTVRRVRSRGINLEKLSEVNEL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 254 VDDITSDGITLEEAYRGLAEIRRNRHPFPSWALTVASGLLSGAASMLVGGGPIVFIAAMVGSMLGDRLAWLASSRGLPEF 333
Cdd:pfam06738  79 SRRIVHGEISLEEAEKRLDEIERSPPRYPRWLVVLAAGLASAAFALLFGGDWIDFLVAFLAGGLGGLLRLVLNRRGLNSF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 334 YQFVVAAMPPAAIGVALSFSHVAVQASAVITGGLFALIPGRALVAAVQDGLTGYYITASARLLEVGYLIVGIVIGVLAAL 413
Cdd:pfam06738 159 FFEAVAAFVASLLALLAVSLGLGINPDAIIIGSIMLLVPGLPLTNAVRDLIAGDLVSGLARLVEAILIALAIAFGIALAL 238

                  ...
gi 2674786627 414 YIG 416
Cdd:pfam06738 239 ALL 241
PRK09917 PRK09917
threonine/serine exporter;
482-578 1.48e-03

threonine/serine exporter;


Pssm-ID: 182143  Cd Length: 157  Bit Score: 39.75  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 482 SGMNAVPATAIAAGLVGLFGQLLSRYRYASALPYVTAAIGPLLPGSATYFGL--------LNFAQGDIGPGVSSLIKAAS 553
Cdd:PRK09917   55 SGLNIEWSTFMASMLVGTIGIQWSRWYLAHPKVFTVAAVIPMFPGISAYTAMisavkishLGYSEPLMITLLTNFLKASS 134
                          90       100
                  ....*....|....*....|....*
gi 2674786627 554 LALAIAVGVNLGGevARLFMKAPGV 578
Cdd:PRK09917  135 IVGALSIGLSLPG--LWLYRKRPRV 157
 
Name Accession Description Interval E-value
YjjP COG2966
Uncharacterized membrane protein YjjP, DUF1212 family [Function unknown];
171-572 2.87e-80

Uncharacterized membrane protein YjjP, DUF1212 family [Function unknown];


Pssm-ID: 442206 [Multi-domain]  Cd Length: 409  Bit Score: 258.71  E-value: 2.87e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 171 RVLDLTLRIGEILLAGGEGAEDVEAAMFGVAHAYGLERVEPTVTFTLLSISYQPSlvDDPVTASRTVRRRGVDYTRLSAV 250
Cdd:COG2966    10 EVLDLALRAGELLLESGAETYRVEDTMLRIAAALGLDEVEVFVTPTSITVSLEDG--DEPITRVRRVRPRGINLEKLAEV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 251 FRLVDDITSDGITLEEAYRGLAEIRRNRHPFPSWALTVASGLLSGAASMLVGGGPIVFIAAMVGSMLGDRLAWLASSRGL 330
Cdd:COG2966    88 NRLSRDLVAGELDLEEARRRLDEIKRAPPRYPRWLVVLAAGLAAAAFALLFGGGWLDFLVAFLAGALGGLLRRLLARRGL 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 331 PEFYQFVVAAMPPAAIGVALSFSHVAVQASAVITGGLFALIPGRALVAAVQDGLTGYYITASARLLEVGYLIVGIVIGVL 410
Cdd:COG2966   168 NPFFVEALAAFVATLIALLLARLGLGLNPDLIIIGSILPLVPGVPLTNAVRDLIAGDLVSGLARLAEALLIALAIAFGVA 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 411 AALYIGLQLNPEYLYPAAGFASFNDPPVQIAAAMMLALAFCVLLQQERHTVLLATLNGGVAWVVYGALANVSGMNAVPAT 490
Cdd:COG2966   248 LALSLLGLLGLPPLPPPPLLPLPPWLLLLLAAAAAAAAFAVLFAARRRLLLLAAALAAAAAAARLLLLLLGGGGSAAAAA 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 491 AIAAGLVGLFGQLLSRYRYASALPYVTAAIGPLLPGSATYFGLLNFAQGDIGPGVSSLIKAASLALAIAVGVNLGGEVAR 570
Cdd:COG2966   328 AAAVAVGGLLAARRRRRPPPVVLVPAAVLVVPPGGGLYLRLLLLLGGGGAGAAAALLLAAAAAALLAGLLGAALAVLLRR 407

                  ..
gi 2674786627 571 LF 572
Cdd:COG2966   408 LL 409
ThrE pfam06738
Putative threonine/serine exporter; ThrE is a family of bacterial and Archaeal proteins that ...
174-416 4.16e-64

Putative threonine/serine exporter; ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.


Pssm-ID: 461997  Cd Length: 241  Bit Score: 210.46  E-value: 4.16e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 174 DLTLRIGEILLAGGEGAEDVEAAMFGVAHAYGLERVEPTVTFTLLSISYQPslVDDPVTASRTVRRRGVDYTRLSAVFRL 253
Cdd:pfam06738   1 DFALRAGRILLESGAETYRVEDTMNRIARALGIDECEVFVTPTGIIISFDD--DDESITTVRRVRSRGINLEKLSEVNEL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 254 VDDITSDGITLEEAYRGLAEIRRNRHPFPSWALTVASGLLSGAASMLVGGGPIVFIAAMVGSMLGDRLAWLASSRGLPEF 333
Cdd:pfam06738  79 SRRIVHGEISLEEAEKRLDEIERSPPRYPRWLVVLAAGLASAAFALLFGGDWIDFLVAFLAGGLGGLLRLVLNRRGLNSF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 334 YQFVVAAMPPAAIGVALSFSHVAVQASAVITGGLFALIPGRALVAAVQDGLTGYYITASARLLEVGYLIVGIVIGVLAAL 413
Cdd:pfam06738 159 FFEAVAAFVASLLALLAVSLGLGINPDAIIIGSIMLLVPGLPLTNAVRDLIAGDLVSGLARLVEAILIALAIAFGIALAL 238

                  ...
gi 2674786627 414 YIG 416
Cdd:pfam06738 239 ALL 241
YjjB COG3610
Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];
450-572 3.13e-25

Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];


Pssm-ID: 442828  Cd Length: 150  Bit Score: 101.81  E-value: 3.13e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 450 FCVLLQQERHTVLLATLNGGVAWVVYGALANVsGMNAVPATAIAAGLVGLFGQLLSRYRYASALPYVTAAIGPLLPGSAT 529
Cdd:COG3610    20 FAVLFNAPRRALLWAGLGGALGWLVYLLLLDL-GLGPVLATFVAALVVGLLAELLARRLKAPATVFTVPGIIPLVPGSGA 98
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2674786627 530 YFGLLNFAQGDIGPGVSSLIKAASLALAIAVGVNLGGEVARLF 572
Cdd:COG3610    99 YRAMYALVEGDYLAALSNGLEALLIAGALAAGLLLGSLLARPR 141
ThrE_2 pfam12821
Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the ...
450-562 3.14e-16

Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.


Pssm-ID: 432807  Cd Length: 129  Bit Score: 75.25  E-value: 3.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 450 FCVLLQQERHTVLLATLNGGVAWVVYGALANVsGMNAVPATAIAAGLVGLFGQLLSRYRYASALPYVTAAIGPLLPGSAT 529
Cdd:pfam12821  12 FGILFNVPKRALFYAGIGGAVGWLVYLLLMHF-GSSIALASFLAALAIGLLSEIFARRLKAPVTVFLVPGIIPLVPGGGA 90
                          90       100       110
                  ....*....|....*....|....*....|...
gi 2674786627 530 YFGLLNFAQGDIGPGVSSLIKAASLALAIAVGV 562
Cdd:pfam12821  91 YNTMYYLVQGNYALAVSYGLETLFIAGAIALGL 123
PRK09917 PRK09917
threonine/serine exporter;
482-578 1.48e-03

threonine/serine exporter;


Pssm-ID: 182143  Cd Length: 157  Bit Score: 39.75  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 482 SGMNAVPATAIAAGLVGLFGQLLSRYRYASALPYVTAAIGPLLPGSATYFGL--------LNFAQGDIGPGVSSLIKAAS 553
Cdd:PRK09917   55 SGLNIEWSTFMASMLVGTIGIQWSRWYLAHPKVFTVAAVIPMFPGISAYTAMisavkishLGYSEPLMITLLTNFLKASS 134
                          90       100
                  ....*....|....*....|....*
gi 2674786627 554 LALAIAVGVNLGGevARLFMKAPGV 578
Cdd:PRK09917  135 IVGALSIGLSLPG--LWLYRKRPRV 157
Voltage_CLC pfam00654
Voltage gated chloride channel; This family of ion channels contains 10 or 12 transmembrane ...
277-426 8.60e-03

Voltage gated chloride channel; This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three ClC subfamilies are found in animals. ClC-1 is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney. These proteins contain two pfam00571 domains.


Pssm-ID: 425802 [Multi-domain]  Cd Length: 344  Bit Score: 38.68  E-value: 8.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 277 NRHPFPSWALTVASGLLSGAASMLVGG-----GPIVFIAAMVGSMLGDRLAwlasSRGLPEFYQFVVAAmppAAIGVALS 351
Cdd:pfam00654  29 HGGRGPLPLRVLPVKFLGTVLTLGSGLslgreGPSVQIGAAIGSGLGRRLF----RLSPRDRRILLAAG---AAAGLAAA 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2674786627 352 FshvavqaSAVITGGLFAL----------IPGRALVAAV-----------QDGLTGYYITASARLLEVGYLIV-GIVIGV 409
Cdd:pfam00654 102 F-------NAPLAGVLFALeelsrsfslrALIPVLLASVvaalvsrlifgNSPLFSVGEPGSLSLLELPLFILlGILCGL 174
                         170
                  ....*....|....*..
gi 2674786627 410 LAALYIGLQLNPEYLYP 426
Cdd:pfam00654 175 LGALFNRLLLKVQRLFR 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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