|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
15-322 |
0e+00 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 553.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 15 FRRSGKSGLKLPEISLGLWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGIPAGSAESHFGDVLASDFKPYRDEMVI 94
Cdd:cd19151 2 YNRCGRSGLKLPAISLGLWHNFGDVDRYENSRAMLRRAFDLGITHFDLANNYGPPPGSAEENFGRILKEDLKPYRDELII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 95 SSKAGYFMWDGPYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQ 174
Cdd:cd19151 82 STKAGYTMWPGPYGDWGSKKYLIASLDQSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVRQGKALYVGISNYPPEE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 175 TLAAKKELDRLGVPLLIHQPRYSMFDRTIERsGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGIPKDSRAAL-GVHLGEE 253
Cdd:cd19151 162 AREAAAILKDLGTPCLIHQPKYSMFNRWVEE-GLLDVLEEEGIGCIAFSPLAQGLLTDRYLNGIPEDSRAAKgSSFLKPE 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2676402920 254 RINEVYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHGPDFEPEELE 322
Cdd:cd19151 241 QITEEKLAKVRRLNEIAQARGQKLAQMALAWVLRNKRVTSVLIGASKPSQIEDAVGALDNREFSEEELA 309
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
15-321 |
0e+00 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 514.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 15 FRRSGKSGLKLPEISLGLWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGIPAGSAESHFGDVLASDFKPYRDEMVI 94
Cdd:cd19089 1 YRRCGRSGLHLPAISLGLWHNFGDYTSPEEARELLRTAFDLGITHFDLANNYGPPPGSAEENFGRILKRDLRPYRDELVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 95 SSKAGYFMWDGPYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQ 174
Cdd:cd19089 81 STKAGYGMWPGPYGDGGSRKYLLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGKALYVGISNYPGAK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 175 TLAAKKELDRLGVPLLIHQPRYSMFDRTIERsGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGIPKDSRAA-LGVHLGEE 253
Cdd:cd19089 161 ARRAIALLRELGVPLIIHQPRYSLLDRWAED-GLLEVLEEAGIGFIAFSPLAQGLLTDKYLNGIPPDSRRAaESKFLTEE 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2676402920 254 RINEVYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHGPDFEPEEL 321
Cdd:cd19089 240 ALTPEKLEQLRKLNKIAAKRGQSLAQLALSWVLRDPRVTSVLIGASSPSQLEDNVAALKNLDFSEEEL 307
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
15-322 |
0e+00 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 508.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 15 FRRSGKSGLKLPEISLGLWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGIPAGSAESHFGDVLASDFKPYRDEMVI 94
Cdd:cd19150 2 YRRCGKSGLKLPALSLGLWHNFGDDTPLETQRAILRTAFDLGITHFDLANNYGPPPGSAEENFGRILREDFAGYRDELII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 95 SSKAGYFMWDGPYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQ 174
Cdd:cd19150 82 STKAGYDMWPGPYGEWGSRKYLLASLDQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALYVGISSYSPER 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 175 TLAAKKELDRLGVPLLIHQPRYSMFDRTIERSGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGIPKDSRAALGVHLGEER 254
Cdd:cd19150 162 TREAAAILRELGTPLLIHQPSYNMLNRWVEESGLLDTLQELGVGCIAFTPLAQGLLTDKYLNGIPEGSRASKERSLSPKM 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2676402920 255 INEVYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHGPDFEPEELE 322
Cdd:cd19150 242 LTEANLNSIRALNEIAQKRGQSLAQMALAWVLRDGRVTSALIGASRPEQLEENVGALDNLTFSADELA 309
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
1-325 |
2.46e-160 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 452.14 E-value: 2.46e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 1 MAYDAASTRYDIMNFRRSGKSGLKLPEISLGLWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGIPAGSAESHFGDV 80
Cdd:PRK09912 1 MVWLANPERYGQMQYRYCGKSGLRLPALSLGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGPPPGSAEENFGRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 81 LASDFKPYRDEMVISSKAGYFMWDGPYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQG 160
Cdd:PRK09912 81 LREDFAAYRDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 161 KALYVGISSYTPEQTLAAKKELDRLGVPLLIHQPRYSMFDRTIERSGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGIPK 240
Cdd:PRK09912 161 KALYVGISSYSPERTQKMVELLREWKIPLLIHQPSYNLLNRWVDKSGLLDTLQNNGVGCIAFTPLAQGLLTGKYLNGIPQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 241 DSR---AALGVH-LGEERINEVYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHGPDF 316
Cdd:PRK09912 241 DSRmhrEGNKVRgLTPKMLTEANLNSLRLLNEMAQQRGQSMAQMALSWLLKDERVTSVLIGASRAEQLEENVQALNNLTF 320
|
....*....
gi 2676402920 317 EPEELEAID 325
Cdd:PRK09912 321 STEELAQID 329
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
13-325 |
1.72e-122 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 354.87 E-value: 1.72e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 13 MNFRRSGKSGLKLPEISLGLWhNFGDEG---SLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASDfkpYR 89
Cdd:COG0667 1 MEYRRLGRSGLKVSRLGLGTM-TFGGPWggvDEAEAIAILDAALDAGINFFDTADVYG--PGRSEELLGEALKGR---PR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 90 DEMVISSKAGYFMWDGPYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISS 169
Cdd:COG0667 75 DDVVIATKVGRRMGPGPNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSN 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 170 YTPEQTLAAKKELDRLgVPLLIHQPRYSMFDRTIERsGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKG--IPKDSRAALG 247
Cdd:COG0667 155 YSAEQLRRALAIAEGL-PPIVAVQNEYSLLDRSAEE-ELLPAARELGVGVLAYSPLAGGLLTGKYRRGatFPEGDRAATN 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2676402920 248 vhLGEERINEVYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHGPdFEPEELEAID 325
Cdd:COG0667 233 --FVQGYLTERNLALVDALRAIAAEHGVTPAQLALAWLLAQPGVTSVIPGARSPEQLEENLAAADLE-LSAEDLAALD 307
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
22-319 |
1.87e-103 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 305.67 E-value: 1.87e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLasdfKPY-RDEMVISSKAGY 100
Cdd:cd19074 1 GLKVSELSLGTWLTFGGQVDDEDAKACVRKAYDLGINFFDTADVYA--AGQAEEVLGKAL----KGWpRESYVISTKVFW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 101 FMWDGPYgEWG-SRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQTLAAK 179
Cdd:cd19074 75 PTGPGPN-DRGlSRKHIFESIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAEAH 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 180 KELDRLG-VPLLIHQPRYSMFDRTIErSGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGIPKDSRAALGVHLG----EER 254
Cdd:cd19074 154 DLARQFGlIPPVVEQPQYNMLWREIE-EEVIPLCEKNGIGLVVWSPLAQGLLTGKYRDGIPPPSRSRATDEDNrdkkRRL 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2676402920 255 INEVYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIhGPDFEPE 319
Cdd:cd19074 233 LTDENLEKVKKLKPIADELGLTLAQLALAWCLRNPAVSSAIIGASRPEQLEENVKAS-GVKLSPE 296
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
13-325 |
3.33e-90 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 272.55 E-value: 3.33e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 13 MNFRRSGKSGLKLPEISLGLWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLAS-DFKpyRDE 91
Cdd:cd19143 1 MEYRRLGRSGLKVSALSFGSWVTFGNQVDVDEAKECMKAAYDAGVNFFDNAEVYA--NGQSEEIMGQAIKElGWP--RSD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 92 MVISSKagyFMWDGPYGEWG----SRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGI 167
Cdd:cd19143 77 YVVSTK---IFWGGGGPPPNdrglSRKHIVEGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGKAFYWGT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 168 SSYTPEQTLAAKKELDRLG-VPLLIHQPRYSMFDRT-IERSGL-LYtlDEIGAGCIVFSPLSQGMLTDRYLKGIPKDSRA 244
Cdd:cd19143 154 SEWSAQQIEEAHEIADRLGlIPPVMEQPQYNLFHRErVEVEYApLY--EKYGLGTTTWSPLASGLLTGKYNNGIPEGSRL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 245 ALGvhlGEERINEVY-------LERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIH-GPDF 316
Cdd:cd19143 232 ALP---GYEWLKDRKeelgqekIEKVRKLKPIAEELGCSLAQLAIAWCLKNPNVSTVITGATKVEQLEENLKALEvLPKL 308
|
....*....
gi 2676402920 317 EPEELEAID 325
Cdd:cd19143 309 TPEVMEKIE 317
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
22-325 |
6.47e-80 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 245.51 E-value: 6.47e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWH---NFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLasdfKPYRDEMVISSKA 98
Cdd:cd19084 1 DLKVSRIGLGTWAiggTWWGEVDDQESIEAIKAAIDLGINFFDTAPVYG--FGHSEEILGKAL----KGRRDDVVIATKC 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 99 GyFMWDGPYGEW--GSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQTL 176
Cdd:cd19084 75 G-LRWDGGKGVTkdLSPESIRKEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGVSNFSVEQLE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 177 AAKKEldrlgVPLLIHQPRYSMFDRTIERSGLLYTLDEiGAGCIVFSPLSQGMLTDRYLKGI---PKDSRAALgVHLGEE 253
Cdd:cd19084 154 EARKY-----GPIVSLQPPYSMLEREIEEELLPYCREN-GIGVLPYGPLAQGLLTGKYKKEPtfpPDDRRSRF-PFFRGE 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2676402920 254 RINEvYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIhGPDFEPEELEAID 325
Cdd:cd19084 227 NFEK-NLEIVDKLKEIAEKYGKSLAQLAIAWTLAQPGVTSAIVGAKNPEQLEENAGAL-DWELTEEELKEID 296
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
28-325 |
1.17e-77 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 239.52 E-value: 1.17e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 28 ISLGLWHNFGDEG--SLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASDfKPYRDEMVISSKAGyfMWDG 105
Cdd:pfam00248 1 IGLGTWQLGGGWGpiSKEEALEALRAALEAGINFIDTAEVYG--DGKSEELLGEALKDY-PVKRDKVVIATKVP--DGDG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 106 PYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQtlaAKKELDRL 185
Cdd:pfam00248 76 PWPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQ---IEKALTKG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 186 GVPLLIHQPRYSMFDRtIERSGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGIPKDSRAALGVHLgeeRINEVYLERVRG 265
Cdd:pfam00248 153 KIPIVAVQVEYNLLRR-RQEEELLEYCKKNGIPLIAYSPLGGGLLTGKYTRDPDKGPGERRRLLK---KGTPLNLEALEA 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 266 LSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHGPdFEPEELEAID 325
Cdd:pfam00248 229 LEEIAKEHGVSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFP-LSDEEVARID 287
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
13-325 |
6.29e-77 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 238.24 E-value: 6.29e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 13 MNFRRSGKSGLKLPEISLGLWhNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASDfkpyRDEM 92
Cdd:cd19087 1 MEYRTLGRTGLKVSRLCLGTM-NFGGRTDEETSFAIMDRALDAGINFFDTADVYG--GGRSEEIIGRWIAGR----RDDI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 93 VISSKAGYFMWDGPYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTP 172
Cdd:cd19087 74 VLATKVFGPMGDDPNDRGLSRRHIRRAVEASLRRLQTDYIDLYQMHHFDRDTPLEETLRALDDLVRQGKIRYIGVSNFAA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 173 EQTLAAKKELDRLGVPLLI-HQPRYSMFDRTIERSGLLYTLDEiGAGCIVFSPLSQGMLTDRYLKGipkdSRAALGVHLG 251
Cdd:cd19087 154 WQIAKAQGIAARRGLLRFVsEQPMYNLLKRQAELEILPAARAY-GLGVIPYSPLAGGLLTGKYGKG----KRPESGRLVE 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2676402920 252 EERINEVYLER-----VRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHgPDFEPEELEAID 325
Cdd:cd19087 229 RARYQARYGLEeyrdiAERFEALAAEAGLTPASLALAWVLSHPAVTSPIIGPRTLEQLEDSLAALE-ITLTPELLAEID 306
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
17-312 |
4.23e-72 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 225.93 E-value: 4.23e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 17 RSGKSGLKLPEISLGLWHnFGDEGSLK------NQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLaSDFKPyRD 90
Cdd:cd19079 4 RLGNSGLKVSRLCLGCMS-FGDPKWRPwvldeeESRPIIKRALDLGINFFDTANVYS--GGASEEILGRAL-KEFAP-RD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 91 EMVISSKAGYFMWDGPYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSY 170
Cdd:cd19079 79 EVVIATKVYFPMGDGPNGRGLSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGASSM 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 171 TPEQ-----TLAAKKELDRlgvpLLIHQPRYSMFDRTIERSGLLYTLDEiGAGCIVFSPLSQGMLTDRYLKG---IPKDS 242
Cdd:cd19079 159 YAWQfakalHLAEKNGWTK----FVSMQNHYNLLYREEEREMIPLCEEE-GIGVIPWSPLARGRLARPWGDTterRRSTT 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 243 RAALGVHLGEERINEVYLERVRglsAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIH 312
Cdd:cd19079 234 DTAKLKYDYFTEADKEIVDRVE---EVAKERGVSMAQVALAWLLSKPGVTAPIVGATKLEHLEDAVAALD 300
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
26-309 |
8.55e-70 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 217.39 E-value: 8.55e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 26 PEISLGLWHnFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASdfKPYRDEMVISSKAGYFMWDG 105
Cdd:cd06660 1 SRLGLGTMT-FGGDGDEEEAFALLDAALEAGGNFFDTADVYG--DGRSERLLGRWLKG--RGNRDDVVIATKGGHPPGGD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 106 PYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQTLAAKKELDRL 185
Cdd:cd06660 76 PSRSRLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYAKAH 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 186 G-VPLLIHQPRYSMFDRTIERSGLLYTLDEIGAGCIVFSPLSQGmltdrylkgipkdsraalgvhlgeerinevylervr 264
Cdd:cd06660 156 GlPGFAAVQPQYSLLDRSPMEEELLDWAEENGLPLLAYSPLARG------------------------------------ 199
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2676402920 265 glsaiaeargqtLAQMALLWTLRNPGVTSALIGASSVKQLEDNIA 309
Cdd:cd06660 200 ------------PAQLALAWLLSQPFVTVPIVGARSPEQLEENLA 232
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
13-325 |
1.01e-66 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 212.47 E-value: 1.01e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 13 MNFRRSGKSGLKLPEISLGLwHNFGDEGSLKNQ---------RAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLas 83
Cdd:cd19091 1 MEYRTLGRSGLKVSELALGT-MTFGGGGGFFGAwggvdqeeaDRLVDIALDAGINFFDTADVYS--EGESEEILGKAL-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 84 dfKPYRDEMVISSKAGYFMWDGPYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKAL 163
Cdd:cd19091 76 --KGRRDDVLIATKVRGRMGEGPNDVGLSRHHIIRAVEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVRQGKVR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 164 YVGISSYTPEQTLAAKKELDRLG-VPLLIHQPRYSMFDRTIERSgLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGIPK-- 240
Cdd:cd19091 154 YIGVSNFSAWQIMKALGISERRGlARFVALQAYYSLLGRDLEHE-LMPLALDQGVGLLVWSPLAGGLLSGKYRRGQPApe 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 241 ---DSRAALGVHlgeeRINEVYLERV-RGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIhGPDF 316
Cdd:cd19091 233 gsrLRRTGFDFP----PVDRERGYDVvDALREIAKETGATPAQVALAWLLSRPTVSSVIIGARNEEQLEDNLGAA-GLSL 307
|
....*....
gi 2676402920 317 EPEELEAID 325
Cdd:cd19091 308 TPEEIARLD 316
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
19-325 |
9.57e-65 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 207.07 E-value: 9.57e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 19 GKSGLKLPEISLGLWhNFGDEGSLKNQRAILRRAFDMGVTHFDLANNY-----GIPAGSAESHFGDVLASDFKpyRDEMV 93
Cdd:cd19081 3 GRTGLSVSPLCLGTM-VFGWTADEETSFALLDAFVDAGGNFIDTADVYsawvpGNAGGESETIIGRWLKSRGK--RDRVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 94 ISSKAGYFMWDGPYGewGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPE 173
Cdd:cd19081 80 IATKVGFPMGPNGPG--LSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKVRYIGASNYSAW 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 174 QTLAAKKELDRLGVPLLIH-QPRYSMFDRT-IERSGLLYTLDEiGAGCIVFSPLSQGMLTDRYLKG--IPKDSRAALGVh 249
Cdd:cd19081 158 RLQEALELSRQHGLPRYVSlQPEYNLVDREsFEGELLPLCREE-GIGVIPYSPLAGGFLTGKYRSEadLPGSTRRGEAA- 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2676402920 250 lgEERINEVYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAiHGPDFEPEELEAID 325
Cdd:cd19081 236 --KRYLNERGLRILDALDEVAAEHGATPAQVALAWLLARPGVTAPIAGARTVEQLEDLLAA-AGLRLTDEEVARLD 308
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
25-325 |
9.80e-65 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 206.67 E-value: 9.80e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 25 LPEISLGLWhNFGDEGSLKNQ-----RAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLasdfKPYRDEMVISSKAG 99
Cdd:cd19085 1 VSRLGLGCW-QFGGGYWWGDQddeesIATIHAALDAGINFFDTAEAYG--DGHSEEVLGKAL----KGRRDDVVIATKVS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 100 YfmwDGPYgewgsRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQTlaak 179
Cdd:cd19085 74 P---DNLT-----PEDVRKSCERSLKRLGTDYIDLYQIHWPSSDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQL---- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 180 KELDRLGvPLLIHQPRYSMFDRTIERSGLLYTLdEIGAGCIVFSPLSQGMLTDRYLKGI---PKDSRAALGVHlGEERIN 256
Cdd:cd19085 142 EEALDAG-RIDSNQLPYNLLWRAIEYEILPFCR-EHGIGVLAYSPLAQGLLTGKFSSAEdfpPGDARTRLFRH-FEPGAE 218
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2676402920 257 EVYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIhGPDFEPEELEAID 325
Cdd:cd19085 219 EETFEALEKLKEIADELGVTMAQLALAWVLQQPGVTSVIVGARNPEQLEENAAAV-DLELSPSVLERLD 286
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
16-325 |
9.37e-62 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 199.37 E-value: 9.37e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 16 RRSGKSGLKLPEISLGLWhNFGDE----GSLKNQRAILRRAFDMGVTHFDLANNYgiPAGSAESHFGDVLASDfkpyRDE 91
Cdd:cd19080 1 RLLGRSGLRVSPLALGTM-TFGTEwgwgADREEARAMFDAYVEAGGNFIDTANNY--TNGTSERLLGEFIAGN----RDR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 92 MVISSKAGYFMWDG-PYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSy 170
Cdd:cd19080 74 IVLATKYTMNRRPGdPNAGGNHRKNLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYVGISD- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 171 TPE------QTLAakkELdRLGVPLLIHQPRYSMFDRTIERSgLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGIPKDSRA 244
Cdd:cd19080 153 TPAwvvaraNTLA---EL-RGWSPFVALQIEYSLLERTPERE-LLPMARALGLGVTPWSPLGGGLLTGKYQRGEEGRAGE 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 245 ALGVHLGEERINEVYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIhGPDFEPEELEAI 324
Cdd:cd19080 228 AKGVTVGFGKLTERNWAIVDVVAAVAEELGRSAAQVALAWVRQKPGVVIPIIGARTLEQLKDNLGAL-DLTLSPEQLARL 306
|
.
gi 2676402920 325 D 325
Cdd:cd19080 307 D 307
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
14-311 |
3.16e-60 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 195.74 E-value: 3.16e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 14 NFRRSGKSGLKLPEISLGLWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASdfKPY-RDEM 92
Cdd:cd19141 1 PYRNLGKSGLRVSCLGLGTWVTFGSQISDEVAEELVTLAYENGINLFDTAEVYA--AGKAEIVLGKILKK--KGWrRSSY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 93 VISSKagyFMWDG-PYGEWG-SRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSY 170
Cdd:cd19141 77 VITTK---IFWGGkAETERGlSRKHIIEGLKASLERLQLEYVDIVFANRPDPNTPMEEIVRAFTHVINQGMAMYWGTSRW 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 171 TPEQTLAAKKELDRLG-VPLLIHQPRYSMFDRTIERSGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGIPKDSRAAL-GV 248
Cdd:cd19141 154 SAMEIMEAYSVARQFNlIPPIVEQAEYHLFQREKVEMQLPELFHKIGVGAMTWSPLACGILSGKYDDGVPEYSRASLkGY 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2676402920 249 HLGEERINEVYLER----VRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAI 311
Cdd:cd19141 234 QWLKEKILSEEGRRqqakLKELQIIADRLGCTLPQLAIAWCLKNEGVSSVLLGASSTEQLYENLQAI 300
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
13-325 |
8.16e-57 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 187.11 E-value: 8.16e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 13 MNFRRSGKSGLKLPEISLGLWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASdfKPYR-DE 91
Cdd:cd19160 3 MKYRNLGKSGLRVSCLGLGTWVTFGSQISDETAEDLLTVAYEHGVNLFDTAEVYA--AGKAERTLGNILKS--KGWRrSS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 92 MVISSKagyFMWDG-PYGEWG-SRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISS 169
Cdd:cd19160 79 YVVTTK---IYWGGqAETERGlSRKHIIEGLRGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGMAMYWGTSR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 170 YTPEQTLAAKKELDRLG-VPLLIHQPRYSMFDRTIERSGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGIPKDSRAAL-G 247
Cdd:cd19160 156 WSAMEIMEAYSVARQFNlIPPVCEQAEYHLFQREKVEMQLPELYHKIGVGSVTWSPLACGLITGKYDGRVPDTCRAAVkG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 248 VHLGEERI----NEVYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHG-PDFEPEELE 322
Cdd:cd19160 236 YQWLKEKVqseeGKKQQAKVKELHPIADRLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLIENLGSIQVlSQLTPQTVM 315
|
...
gi 2676402920 323 AID 325
Cdd:cd19160 316 EID 318
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
13-312 |
1.61e-56 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 186.40 E-value: 1.61e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 13 MNFRRSGKSGLKLPEISLGLWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASdfKPYR-DE 91
Cdd:cd19159 1 MKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYA--AGKAEVILGSIIKK--KGWRrSS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 92 MVISSKagyFMWDGPY-GEWG-SRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISS 169
Cdd:cd19159 77 LVITTK---LYWGGKAeTERGlSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 170 YTPEQTLAAKKELDRLG-VPLLIHQPRYSMFDRTIERSGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGIPKDSRAALGV 248
Cdd:cd19159 154 WSAMEIMEAYSVARQFNmIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKC 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2676402920 249 H--LGEERINE---VYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIH 312
Cdd:cd19159 234 YqwLKERIVSEegrKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQ 302
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
13-312 |
1.99e-54 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 181.05 E-value: 1.99e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 13 MNFRRSGKSGLKLPEISLGLWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASdfKPYR-DE 91
Cdd:cd19158 1 QFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYA--AGKAEVVLGNIIKK--KGWRrSS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 92 MVISSKagyFMWDGPY-GEWG-SRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISS 169
Cdd:cd19158 77 LVITTK---IFWGGKAeTERGlSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 170 YTPEQTLAAKKELDRLG-VPLLIHQPRYSMFDRTIERSGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGIPKDSRAAL-G 247
Cdd:cd19158 154 WSSMEIMEAYSVARQFNlIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLkG 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2676402920 248 VHLGEERI----NEVYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIH 312
Cdd:cd19158 234 YQWLKDKIlseeGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQ 302
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
15-311 |
9.18e-54 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 179.01 E-value: 9.18e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 15 FRRSGKSGLKLPEISLGLWHNFGD--EGSLKNQRAI--LRRAFDMGVTHFDLANNYGIpaGSAESHFGDVLasdfKPYRD 90
Cdd:cd19149 1 YRKLGKSGIEASVIGLGTWAIGGGpwWGGSDDNESIrtIHAALDLGINLIDTAPAYGF--GHSEEIVGKAI----KGRRD 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 91 EMVISSKAGyFMWDGPYGEWGS-------RKYL-----ISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQ 158
Cdd:cd19149 75 KVVLATKCG-LRWDREGGSFFFvrdgvtvYKNLspesiREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALEELKR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 159 QGKALYVGISSYTPEQTLAAKK--ELDrlgvpllIHQPRYSMFDRTIERSGLLYTLDEiGAGCIVFSPLSQGMLTDRYLK 236
Cdd:cd19149 154 QGKIRAIGASNVSVEQIKEYVKagQLD-------IIQEKYSMLDRGIEKELLPYCKKN-NIAFQAYSPLEQGLLTGKITP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 237 -----------GIPKDSRAALgvhlgeERINEVyLERVRglsAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLE 305
Cdd:cd19149 226 drefdagdarsGIPWFSPENR------EKVLAL-LEKWK---PLCEKYGCTLAQLVIAWTLAQPGITSALCGARKPEQAE 295
|
....*.
gi 2676402920 306 DNIAAI 311
Cdd:cd19149 296 ENAKAG 301
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
16-324 |
1.38e-53 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 178.18 E-value: 1.38e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 16 RRSGKSGLKLPEISLG---LWHNFG---DEGSLknqrAILRRAFDMGVTHFDLANNYGipAGSAEshfgDVLASDFKPYR 89
Cdd:cd19076 3 RKLGTQGLEVSALGLGcmgMSAFYGpadEEESI----ATLHRALELGVTFLDTADMYG--PGTNE----ELLGKALKDRR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 90 DEMVISSKAGYFMWDGPY--GEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGI 167
Cdd:cd19076 73 DEVVIATKFGIVRDPGSGfrGVDGRPEYVRAACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMAELVEEGKVRYIGL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 168 SSYTPEQTLAAKKeldrlgvpllIH-----QPRYSMFDRTIERsGLLYTLDEIGAGCIVFSPLSQGMLTDRY--LKGIPK 240
Cdd:cd19076 153 SEASADTIRRAHA----------VHpitavQSEYSLWTRDIED-EVLPTCRELGIGFVAYSPLGRGFLTGAIksPEDLPE 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 241 -DSRAALGVHLGEERinEVYLERVRGLSAIAEARGQTLAQMALLWTL-RNPGVTsALIGASSVKQLEDNIAAIhgpDFE- 317
Cdd:cd19076 222 dDFRRNNPRFQGENF--DKNLKLVEKLEAIAAEKGCTPAQLALAWVLaQGDDIV-PIPGTKRIKYLEENVGAL---DVVl 295
|
....*...
gi 2676402920 318 -PEELEAI 324
Cdd:cd19076 296 tPEELAEI 303
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
24-325 |
4.10e-51 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 171.26 E-value: 4.10e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 24 KLPEISLGLWH------NFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGIpaGSAESHFGDVLASDfkPYRDEMVISSK 97
Cdd:cd19093 1 EVSPLGLGTWQwgdrlwWGYGEYGDEDLQAAFDAALEAGVNLFDTAEVYGT--GRSERLLGRFLKEL--GDRDEVVIATK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 98 -AGYFmWDGPygewgsRKYLISSLDQSLKRMGLDYVDIFYSHRPDPN-TPIEETMGALASVVQQGKALYVGISSYTPEQT 175
Cdd:cd19093 77 fAPLP-WRLT------RRSVVKALKASLERLGLDSIDLYQLHWPGPWySQIEALMDGLADAVEEGLVRAVGVSNYSADQL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 176 LAAKKELDRLGVPLLIHQPRYSMFDRTIERSGLLYTLDEIGAGCIVFSPLSQGMLTDRY-LKGIPKDSRAALGVHLGEER 254
Cdd:cd19093 150 RRAHKALKERGVPLASNQVEYSLLYRDPEQNGLLPACDELGITLIAYSPLAQGLLTGKYsPENPPPGGRRRLFGRKNLEK 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2676402920 255 INEVyLERVRglsAIAEARGQTLAQMALLWTLRNPGVtsALIGASSVKQLEDNIAAIhGPDFEPEELEAID 325
Cdd:cd19093 230 VQPL-LDALE---EIAEKYGKTPAQVALNWLIAKGVV--PIPGAKNAEQAEENAGAL-GWRLSEEEVAELD 293
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
16-325 |
7.60e-51 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 171.06 E-value: 7.60e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 16 RRSGKSGLKLPEISLG--------LWHNFGDEgslkNQRAILRRAFDMGVTHFDLANNYGIpaGSAESHFGDVLAsDFKp 87
Cdd:cd19083 2 VKLGKSDIDVNPIGLGtnavgghnLYPNLDEE----EGKDLVREALDNGVNLLDTAFIYGL--GRSEELVGEVLK-EYN- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 88 yRDEMVISSKAGYFMWDGPYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGI 167
Cdd:cd19083 74 -RNEVVIATKGAHKFGGDGSVLNNSPEFLRSAVEKSLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRAIGV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 168 SSYTPEQTLAAKKE--LDRLgvpllihQPRYSMFDRTIERSGLLYTLDEiGAGCIVFSPLSQGMLTDRYLKGI---PKDS 242
Cdd:cd19083 153 SNFSLEQLKEANKDgyVDVL-------QGEYNLLQREAEEDILPYCVEN-NISFIPYFPLASGLLAGKYTKDTkfpDNDL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 243 RAALGvHLGEERINEVyLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHGpDFEPEELE 322
Cdd:cd19083 225 RNDKP-LFKGERFSEN-LDKVDKLKSIADEKGVTVAHLALAWYLTRPAIDVVIPGAKRAEQVIDNLKALDV-TLTEEEIA 301
|
...
gi 2676402920 323 AID 325
Cdd:cd19083 302 FID 304
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
27-325 |
1.00e-50 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 171.59 E-value: 1.00e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 27 EISLGLWHnFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGIPA-----GSAESHFGDVLASdfKPYRDEMVISSK-AGY 100
Cdd:cd19094 3 EICLGTMT-WGEQNTEAEAHEQLDYAFDEGVNFIDTAEMYPVPPspetqGRTEEIIGSWLKK--KGNRDKVVLATKvAGP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 101 --FMWDGPYGEWG-SRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTP------------------IEETMGALASVVQQ 159
Cdd:cd19094 80 geGITWPRGGGTRlDRENIREAVEGSLKRLGTDYIDLYQLHWPDRYTPlfgggyytepseeedsvsFEEQLEALGELVKA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 160 GKALYVGISSYTPEQTLAAKKELDRLGVPLLIH-QPRYSMFDRTIERSgllytLDEI----GAGCIVFSPLSQGMLTDRY 234
Cdd:cd19094 160 GKIRHIGLSNETPWGVMKFLELAEQLGLPRIVSiQNPYSLLNRNFEEG-----LAEAchreNVGLLAYSPLAGGVLTGKY 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 235 LKG--IPKDSRAALGVHLGEERINEVYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIH 312
Cdd:cd19094 235 LDGaaRPEGGRLNLFPGYMARYRSPQALEAVAEYVKLARKHGLSPAQLALAWVRSRPFVTSTIIGATTLEQLKENIDAFD 314
|
330
....*....|...
gi 2676402920 313 GPdFEPEELEAID 325
Cdd:cd19094 315 VP-LSDELLAEID 326
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
28-328 |
1.31e-48 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 165.15 E-value: 1.31e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 28 ISLGLW-----HNFGDEGSLKNQRAI--LRRAFDMGVTHFDLANNYGIpaGSAESHFGDVLasdfKPYRDEMVISSKAGy 100
Cdd:cd19102 4 IGLGTWaigggGWGGGWGPQDDRDSIaaIRAALDLGINWIDTAAVYGL--GHSEEVVGRAL----KGLRDRPIVATKCG- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 101 FMWD--GPYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQTLAA 178
Cdd:cd19102 77 LLWDeeGRIRRSLKPASIRAECEASLRRLGVDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 179 KKeldrlgvpllIH-----QPRYSMFDRTIERSGLLYTlDEIGAGCIVFSPLSQGMLTDR----YLKGIPKDSRAALGVH 249
Cdd:cd19102 157 QA----------IHpiaslQPPYSLLRRGIEAEILPFC-AEHGIGVIVYSPMQSGLLTGKmtpeRVASLPADDWRRRSPF 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 250 LGEERINEvYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAihgPDFE--PEELEAIDVF 327
Cdd:cd19102 226 FQEPNLAR-NLALVDALRPIAERHGRTVAQLAIAWVLRRPEVTSAIVGARRPDQIDETVGA---ADLRltPEELAEIEAL 301
|
.
gi 2676402920 328 A 328
Cdd:cd19102 302 L 302
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
22-325 |
1.52e-48 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 165.10 E-value: 1.52e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLG---LWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGIPAGsaESHFGDVLasdfKPYRDEMVISSKA 98
Cdd:cd19078 1 GLEVSAIGLGcmgMSHGYGPPPDKEEMIELIRKAVELGITFFDTAEVYGPYTN--EELVGEAL----KPFRDQVVIATKF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 99 GyFMWDGPYGEWG---SRKYLI-SSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQ 174
Cdd:cd19078 75 G-FKIDGGKPGPLgldSRPEHIrKAVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLSEAGVET 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 175 TLAAKKELdrlgvPLLIHQPRYSMFDRTIErSGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGI---PKDSRAALgvhlg 251
Cdd:cd19078 154 IRRAHAVC-----PVTAVQSEYSMMWREPE-KEVLPTLEELGIGFVPFSPLGKGFLTGKIDENTkfdEGDDRASL----- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 252 eERINEVYLER----VRGLSAIAEARGQTLAQMALLWTLRN-------PGVTsaligasSVKQLEDNIAAIHgPDFEPEE 320
Cdd:cd19078 223 -PRFTPEALEAnqalVDLLKEFAEEKGATPAQIALAWLLAKkpwivpiPGTT-------KLSRLEENIGAAD-IELTPEE 293
|
....*
gi 2676402920 321 LEAID 325
Cdd:cd19078 294 LREIE 298
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
23-310 |
7.98e-47 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 158.41 E-value: 7.98e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 23 LKLPEISLGLW-------HNFGDEGSLknqrAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASDfkpyRDEMVIS 95
Cdd:cd19086 1 LEVSEIGFGTWglggdwwGDVDDAEAI----RALRAALDLGINFFDTADVYG--DGHSERLLGKALKGR----RDKVVIA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 96 SKAGYFMWDGPYGEWG-SRKYLISSLDQSLKRMGLDYVDIFYSHRPDPN-TPIEETMGALASVVQQGKALYVGISSYTPE 173
Cdd:cd19086 71 TKFGNRFDGGPERPQDfSPEYIREAVEASLKRLGTDYIDLYQLHNPPDEvLDNDELFEALEKLKQEGKIRAYGVSVGDPE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 174 QTLAAkkeLDRLGVPLLihQPRYSMFDRTIERsGLLYTLDEIGAGCIVFSPLSQGMLTDRylkgipkdsraalgvhlgee 253
Cdd:cd19086 151 EALAA---LRRGGIDVV--QVIYNLLDQRPEE-ELFPLAEEHGVGVIARVPLASGLLTGK-------------------- 204
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2676402920 254 rinevylervrglsaiaeargqtLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAA 310
Cdd:cd19086 205 -----------------------LAQAALRFILSHPAVSTVIPGARSPEQVEENAAA 238
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
13-324 |
1.01e-45 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 158.40 E-value: 1.01e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 13 MNFRRSGKSGLKLPEISLGLWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYgiPAGSAESHFGDVLASDFKPyRDEM 92
Cdd:cd19142 1 LKYRNLGKSGLRVSNVGLGTWSTFSTAISEEQAEEIVTLAYENGINYFDTSDAF--TSGQAETELGRILKKKGWK-RSSY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 93 VISSKagyFMWD-GPYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYT 171
Cdd:cd19142 78 IVSTK---IYWSyGSEERGLSRKHIIESVRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMSYLIDNGLIMYWGTSRWS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 172 PEQTLAAKKELDRLGVPLLI-HQPRYSMFDRTIERSGLLYTLDEIGAGCIVFSPLS------QGMLTDRYLKGIPKDSRA 244
Cdd:cd19142 155 PVEIMEAFSIARQFNCPTPIcEQSEYHMFCREKMELYMPELYNKVGVGLITWSPLSlgldpgISEETRRLVTKLSFKSSK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 245 ALGVHLGEERINE--VYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIH-GPDFEP--- 318
Cdd:cd19142 235 YKVGSDGNGIHEEtrRASHKLRELSLIAERLGCDLTQLLIAWSLKNENVQCVLIGASSLEQLYSQLNSLQlLPKLNSavm 314
|
....*.
gi 2676402920 319 EELEAI 324
Cdd:cd19142 315 EELERI 320
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
20-311 |
2.59e-43 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 150.78 E-value: 2.59e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 20 KSGLKLPEISLGLWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASDfKPYRDEMVISSKAG 99
Cdd:cd19092 1 PEGLEVSRLVLGCMRLADWGESAEELLSLIEAALELGITTFDHADIYG--GGKCEELFGEALALN-PGLREKIEIQTKCG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 100 YFMWDGPYGEWG-----SRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQ 174
Cdd:cd19092 78 IRLGDDPRPGRIkhydtSKEHILASVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFGVSNFTPSQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 175 TLAAKKELDrlgVPLLIHQPRYSMFDRTIERSGLLYTLDEIGAGCIVFSPLSQGMLTDrylkgiPKDSRAalgvhlgeER 254
Cdd:cd19092 158 IELLQSYLD---QPLVTNQIELSLLHTEAIDDGTLDYCQLLDITPMAWSPLGGGRLFG------GFDERF--------QR 220
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2676402920 255 INEVylervrgLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAI 311
Cdd:cd19092 221 LRAA-------LEELAEEYGVTIEAIALAWLLRHPARIQPILGTTNPERIRSAVKAL 270
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
26-310 |
2.98e-43 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 149.69 E-value: 2.98e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 26 PEISLGLWHNFGDEG--SLKNQRAILRRAFDMGVTHFDLANNYGipagSAESHFGDVLASDFkpyRDEMVISSKAGYFmW 103
Cdd:cd19095 1 SVLGLGTSGIGRVWGvpSEAEAARLLNTALDLGINLIDTAPAYG----RSEERLGRALAGLR---RDDLFIATKVGTH-G 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 104 DG--PYGEWgSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPE-QTLAAKK 180
Cdd:cd19095 73 EGgrDRKDF-SPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVLETLEDLKAAGKVRYIGVSGDGEElEAAIASG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 181 ELDRLgvpllihQPRYSMFDRTIERsgLLYTLDEIGAGCIVFSPLSQGMLTDRylkgipkdsraalgvhlgeERINEVYL 260
Cdd:cd19095 152 VFDVV-------QLPYNVLDREEEE--LLPLAAEAGLGVIVNRPLANGRLRRR-------------------VRRRPLYA 203
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2676402920 261 ERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAA 310
Cdd:cd19095 204 DYARRPEFAAEIGGATWAQAALRFVLSHPGVSSAIVGTTNPEHLEENLAA 253
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
22-325 |
6.39e-43 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 149.30 E-value: 6.39e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLW-------HNFGDEgslKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLaSDFKpyRDEMVI 94
Cdd:cd19072 1 GEEVPVLGLGTWgigggmsKDYSDD---KKAIEALRYAIELGINLIDTAEMYG--GGHAEELVGKAI-KGFD--REDLFI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 95 SSKAgyfmwdgpYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQ 174
Cdd:cd19072 73 TTKV--------SPDHLKYDDVIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSNFSLEE 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 175 TLAAKKELDRlgVPLLIHQPRYSMFDRTIErSGLLYTLDEIGAGCIVFSPLSQGMLTDRylkgipkdsraalgvhlgeer 254
Cdd:cd19072 145 LEEAQSYLKK--GPIVANQVEYNLFDREEE-SGLLPYCQKNGIAIIAYSPLEKGKLSNA--------------------- 200
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2676402920 255 inevylERVRGLSAIAEARGQTLAQMALLWTLRNPGVTsALIGASSVKQLEDNIAAIhGPDFEPEELEAID 325
Cdd:cd19072 201 ------KGSPLLDEIAKKYGKTPAQIALNWLISKPNVI-AIPKASNIEHLEENAGAL-GWELSEEDLQRLD 263
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
22-325 |
2.30e-42 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 148.99 E-value: 2.30e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWHNFG------DEgslKNQRAILRRAFDMGVTHFDLANNYGIpaGSAESHFGDVLASDFKpyRDEMVIS 95
Cdd:cd19148 1 DLPVSRIALGTWAIGGwmwggtDE---KEAIETIHKALDLGINLIDTAPVYGF--GLSEEIVGKALKEYGK--RDRVVIA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 96 SKAGyFMWD--GPYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPE 173
Cdd:cd19148 74 TKVG-LEWDegGEVVRNSSPARIRKEVEDSLRRLQTDYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGVSNFSPE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 174 QTlaakkELDRLGVPLLIHQPRYSMFDRTIERSGLLYTLDEiGAGCIVFSPLSQGMLTDRYLKG--IPKDSRAALGVHLG 251
Cdd:cd19148 153 QM-----ETFRKVAPLHTVQPPYNLFEREIEKDVLPYARKH-NIVTLAYGALCRGLLSGKMTKDtkFEGDDLRRTDPKFQ 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2676402920 252 EERINEvYLERVRGLSAIAEAR-GQTLAQMALLWTLRNPGVTSALIGASSVKQLEDnIAAIHGPDFEPEELEAID 325
Cdd:cd19148 227 EPRFSQ-YLAAVEELDKLAQERyGKSVIHLAVRWLLDQPGVSIALWGARKPEQLDA-VDEVFGWSLNDEDMKEID 299
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
46-310 |
5.29e-42 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 146.59 E-value: 5.29e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 46 RAILRRAFDMGVTHFDLANNYGIpaGSAESHFGDVLasdfKPYRDEMVISSKAGYFMwDGPyGEW---GSRKYLISSLDQ 122
Cdd:cd19088 27 IAVLRRALELGVNFIDTADSYGP--DVNERLIAEAL----HPYPDDVVIATKGGLVR-TGP-GWWgpdGSPEYLRQAVEA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 123 SLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQTLAAKKELDRLGVpllihQPRYSMFDRt 202
Cdd:cd19088 99 SLRRLGLDRIDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEEARAIVRIVSV-----QNRYNLANR- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 203 iERSGLLYTLDEIGAGCIVFSPLSQGMLtdrylkgipkdsraalgvhlgeerinevyLERVRGLSAIAEARGQTLAQMAL 282
Cdd:cd19088 173 -DDEGVLDYCEAAGIAFIPWFPLGGGDL-----------------------------AQPGGLLAEVAARLGATPAQVAL 222
|
250 260
....*....|....*....|....*...
gi 2676402920 283 LWTLRNPGVTSALIGASSVKQLEDNIAA 310
Cdd:cd19088 223 AWLLARSPVMLPIPGTSSVEHLEENLAA 250
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
16-332 |
8.69e-42 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 147.97 E-value: 8.69e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 16 RRSGKSGLKLPEI---SLGLWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipagSAEshfgDVLASDFKP---YR 89
Cdd:cd19144 4 RTLGRNGPSVPALgfgAMGLSAFYGPPKPDEERFAVLDAAFELGCTFWDTADIYG----DSE----ELIGRWFKQnpgKR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 90 DEMVISSKAGYFMwDGPYGEW---GSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVG 166
Cdd:cd19144 76 EKIFLATKFGIEK-NVETGEYsvdGSPEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIKHIG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 167 ISSYTPEqTL--AAKKEldrlgvPLLIHQPRYSMFDRTIERS--GLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGI---P 239
Cdd:cd19144 155 LSECSAE-TLrrAHAVH------PIAAVQIEYSPFSLDIERPeiGVLDTCRELGVAIVAYSPLGRGFLTGAIRSPDdfeE 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 240 KDSRAALGvHLGEERINEVyLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHGPDFEPE 319
Cdd:cd19144 228 GDFRRMAP-RFQAENFPKN-LELVDKIKAIAKKKNVTAGQLTLAWLLAQGDDIIPIPGTTKLKRLEENLGALKVKLTEEE 305
|
330
....*....|....*.
gi 2676402920 320 ELE---AIDVFAVHGT 332
Cdd:cd19144 306 EKEireIAEEAEVVGE 321
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
26-325 |
1.05e-41 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 147.32 E-value: 1.05e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 26 PEISLGLwHNFGDEGSLKN---QRAILRRAFDMGVTHFDLANNYgiPAGSAESHFGDVLASDFKpyrdeMVISSKAgyFM 102
Cdd:cd19075 1 PKIILGT-MTFGSQGRFTTaeaAAELLDAFLERGHTEIDTARVY--PDGTSEELLGELGLGERG-----FKIDTKA--NP 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 103 WDGPygeWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQ-----TLA 177
Cdd:cd19075 71 GVGG---GLSPENVRKQLETSLKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEvaeivEIC 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 178 AKKeldrlGVPL-LIHQPRYSMFDRTIErSGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKG--IPKDSR----AALGVHL 250
Cdd:cd19075 148 KEN-----GWVLpTVYQGMYNAITRQVE-TELFPCLRKLGIRFYAYSPLAGGFLTGKYKYSedKAGGGRfdpnNALGKLY 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 251 GEERINEVYLERVRGLSAIAEARGQTLAQMALLWTLRNpgvtSAL---------IGASSVKQLEDNIAAI-HGPdFEPEE 320
Cdd:cd19075 222 RDRYWKPSYFEALEKVEEAAEKEGISLAEAALRWLYHH----SALdgekgdgviLGASSLEQLEENLAALeKGP-LPEEV 296
|
....*
gi 2676402920 321 LEAID 325
Cdd:cd19075 297 VKAID 301
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
13-320 |
1.13e-40 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 144.23 E-value: 1.13e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 13 MNFRRSGKSGLKLPEISLG------LWHNFGDEGSLKnqraILRRAFDMGVTHFDLANNYGIpaGSAESHFGDVLaSDFK 86
Cdd:cd19163 1 MKYRKLGKTGLKVSKLGFGasplggVFGPVDEEEAIR----TVHEALDSGINYIDTAPWYGQ--GRSETVLGKAL-KGIP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 87 pyRDEMVISSKAGYF------MWDGpygewgSRKYLISSLDQSLKRMGLDYVDIFYSH----RPDPNTPIEETMGALASV 156
Cdd:cd19163 74 --RDSYYLATKVGRYgldpdkMFDF------SAERITKSVEESLKRLGLDYIDIIQVHdiefAPSLDQILNETLPALQKL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 157 VQQGKALYVGISSYtPEQTLaaKKELDRLGVPL--LIHQPRYSMFDRTIerSGLLYTLDEIGAGCIVFSPLSQGMLTDRy 234
Cdd:cd19163 146 KEEGKVRFIGITGY-PLDVL--KEVLERSPVKIdtVLSYCHYTLNDTSL--LELLPFFKEKGVGVINASPLSMGLLTER- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 235 lkGIPkdsraalGVHLGEERInevyLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHGP 314
Cdd:cd19163 220 --GPP-------DWHPASPEI----KEACAKAAAYCKSRGVDISKLALQFALSNPDIATTLVGTASPENLRKNLEAAEEP 286
|
....*.
gi 2676402920 315 DFEPEE 320
Cdd:cd19163 287 LDAHLL 292
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
35-310 |
1.22e-39 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 141.54 E-value: 1.22e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 35 NFGDEGSLKNQRAILRRAFDMGVTHFDLANNYG--IPAGSAESHFGDVLASDFKpyRDEMVISSKAGYFMWDGPYGEWGS 112
Cdd:cd19082 9 DFGTRIDEEEAFALLDAFVELGGNFIDTARVYGdwVERGASERVIGEWLKSRGN--RDKVVIATKGGHPDLEDMSRSRLS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 113 RKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQTLAAKKELDRLG-VPLLI 191
Cdd:cd19082 87 PEDIRADLEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGASNWSTERIAEANAYAKAHGlPGFAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 192 HQPRYSMFDRTIER---SGLLYTLDEI-------GAGCIVFSPLSQGMLTDRYLKGIPKDSRAAlgvhlgEERINEVYLE 261
Cdd:cd19082 167 SSPQWSLARPNEPPwpgPTLVAMDEEMrawheenQLPVFAYSSQARGFFSKRAAGGAEDDSELR------RVYYSEENFE 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2676402920 262 RVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAA 310
Cdd:cd19082 241 RLERAKELAEEKGVSPTQIALAYVLNQPFPTVPIIGPRTPEQLRDSLAA 289
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
26-314 |
1.70e-38 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 138.07 E-value: 1.70e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 26 PEISLG------LWHNFGDEGSLknqrAILRRAFDMGVTHFDLANNYGipagSAESHFGDVLAsdfKPYRDEMVISSKAG 99
Cdd:cd19090 1 SALGLGtaglggVFGGVDDDEAV----ATIRAALDLGINYIDTAPAYG----DSEERLGLALA---ELPREPLVLSTKVG 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 100 YFM-WDGPYgewgSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTP-----IEETMGALASVVQQGKALYVGISSYTPE 173
Cdd:cd19090 70 RLPeDTADY----SADRVRRSVEESLERLGRDRIDLLMIHDPERVPWvdilaPGGALEALLELKEEGLIKHIGLGGGPPD 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 174 qtlAAKKELDRlGVP--LLIHQpRYSMFDRTIERSgLLYTLDEIGAGCIVFSPLSQGMLTDRylkgiPKDSRAALGVHLG 251
Cdd:cd19090 146 ---LLRRAIET-GDFdvVLTAN-RYTLLDQSAADE-LLPAAARHGVGVINASPLGMGLLAGR-----PPERVRYTYRWLS 214
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2676402920 252 EERInevylERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHGP 314
Cdd:cd19090 215 PELL-----DRAKRLYELCDEHGVPLPALALRFLLRDPRISTVLVGASSPEELEQNVAAAEGP 272
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
13-311 |
2.73e-38 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 136.56 E-value: 2.73e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 13 MNFRRSGKSGLKLPEISlglwhnFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLAsdfKPYRDEM 92
Cdd:cd19105 1 MPYRTLGKTGLKVSRLG------FGGGGLPRESPELLRRALDLGINYFDTAEGYG--NGNSEEIIGEALK---GLRRDKV 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 93 VISSKAGyfmwdgPYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPI---EETMGALASVVQQGKALYVGISS 169
Cdd:cd19105 70 FLATKAS------PRLDKKDKAELLKSVEESLKRLQTDYIDIYQLHGVDTPEERllnEELLEALEKLKKEGKVRFIGFST 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 170 YTPE----QTLAAKKELDrlgvpllIHQPRYSMFDRTIERSGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGIPKdsraa 245
Cdd:cd19105 144 HDNMaevlQAAIESGWFD-------VIMVAYNFLNQPAELEEALAAAAEKGIGVVAMKTLAGGYLQPALLSVLKA----- 211
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2676402920 246 lgvhlgeerinevylervrglsaiaeaRGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAI 311
Cdd:cd19105 212 ---------------------------KGFSLPQAALKWVLSNPRVDTVVPGMRNFAELEENLAAA 250
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
47-325 |
5.75e-38 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 137.37 E-value: 5.75e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 47 AILRRAFDMGVTHFDLANNYGIPAGSAESHfgdVLASDFK---PYRDEMVISSKAGY-FMWDGPYGewgSRKYLISSLDQ 122
Cdd:cd19077 29 ETMKAALDAGSNLWNGGEFYGPPDPHANLK---LLARFFRkypEYADKVVLSVKGGLdPDTLRPDG---SPEAVRKSIEN 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 123 SLKRMG-LDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQTLAAKKEldrlgVPLLIHQPRYSMFDR 201
Cdd:cd19077 103 ILRALGgTKKIDIFEPARVDPNVPIEETIKALKELVKEGKIRGIGLSEVSAETIRRAHAV-----HPIAAVEVEYSLFSR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 202 TIERSGLLYTLDEIGAGCIVFSPLSQGMLTDRY--LKGIP-KDSRAALgvhlgeERIN-EVY---LERVRGLSAIAEARG 274
Cdd:cd19077 178 EIEENGVLETCAELGIPIIAYSPLGRGLLTGRIksLADIPeGDFRRHL------DRFNgENFeknLKLVDALQELAEKKG 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 2676402920 275 QTLAQMALLWTLRNPGvtsALI----GASSVKQLEDNIAAIHgPDFEPEELEAID 325
Cdd:cd19077 252 CTPAQLALAWILAQSG---PKIipipGSTTLERVEENLKAAN-VELTDEELKEIN 302
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
21-325 |
1.03e-37 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 135.45 E-value: 1.03e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLGLWHnFGDEGSLKNQ-RAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASDfkpyRDEMVISSKAg 99
Cdd:cd19138 7 DGTKVPALGQGTWY-MGEDPAKRAQeIEALRAGIDLGMTLIDTAEMYG--DGGSEELVGEAIRGR----RDKVFLVSKV- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 100 yfmwdgpYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDpNTPIEETMGALASVVQQGKALYVGISSYTPEQTlaak 179
Cdd:cd19138 79 -------LPSNASRQGTVRACERSLRRLGTDYLDLYLLHWRG-GVPLAETVAAMEELKKEGKIRAWGVSNFDTDDM---- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 180 KELDRL--GVPLLIHQPRYSMFDRTIERSgLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGIPkdsraalgvhlgeerine 257
Cdd:cd19138 147 EELWAVpgGGNCAANQVLYNLGSRGIEYD-LLPWCREHGVPVMAYSPLAQGGLLRRGLLENP------------------ 207
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 258 vylervrGLSAIAEARGQTLAQMALLWTLRNPGVTsALIGASSVKQLEDNIAAIhgpDFE--PEELEAID 325
Cdd:cd19138 208 -------TLKEIAARHGATPAQVALAWVLRDGNVI-AIPKSGSPEHARENAAAA---DLEltEEDLAELD 266
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
19-324 |
5.62e-37 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 134.87 E-value: 5.62e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 19 GKSGLKLPEISLGLWHNFGDEGSLKNQR---AILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASdfkPYRDEMVIS 95
Cdd:cd19145 6 GSQGLEVSAQGLGCMGLSGDYGAPKPEEegiALIHHAFNSGVTFLDTSDIYG--PNTNEVLLGKALKD---GPREKVQLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 96 SKAGYFMWDGPYGEW-GSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQ 174
Cdd:cd19145 81 TKFGIHEIGGSGVEVrGDPAYVRAACEASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYIGLSEASADT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 175 TLAAKkeldrlGV-PLLIHQPRYSMFDRTIERSgLLYTLDEIGAGCIVFSPLSQGML-----------TDRYLKGIPKDS 242
Cdd:cd19145 161 IRRAH------AVhPITAVQLEWSLWTRDIEEE-IIPTCRELGIGIVPYSPLGRGFFagkakleelleNSDVRKSHPRFQ 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 243 RAALgvhlgeERiNEVYLERVrglSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIhGPDFEPEELE 322
Cdd:cd19145 234 GENL------EK-NKVLYERV---EALAKKKGCTPAQLALAWVLHQGEDVVPIPGTTKIKNLNQNIGAL-SVKLTKEDLK 302
|
..
gi 2676402920 323 AI 324
Cdd:cd19145 303 EI 304
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
22-325 |
1.37e-35 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 130.00 E-value: 1.37e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWhnfGDEGSL-----KNQRAI--LRRAFDMGVTHFDLANNYGipAGSAESHFGDVLaSDFKpyRDEMVI 94
Cdd:cd19137 1 GEKIPALGLGTW---GIGGFLtpdysRDEEMVelLKTAIELGYTHIDTAEMYG--GGHTEELVGKAI-KDFP--REDLFI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 95 SSKagyfMWDgpygEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQ 174
Cdd:cd19137 73 VTK----VWP----TNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 175 TLAAKKeldRLGVPLLIHQPRYSMFDRTIERSGLLYTLDEIGAGCIVFSPLSQGMltdrylkgipkdsraalgvhlgeER 254
Cdd:cd19137 145 LEEAIS---KSQTPIVCNQVKYNLEDRDPERDGLLEYCQKNGITVVAYSPLRRGL-----------------------EK 198
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2676402920 255 INEVylervrgLSAIAEARGQTLAQMALLWTLRNPGVTsALIGASSVKQLEDNIAAIhGPDFEPEELEAID 325
Cdd:cd19137 199 TNRT-------LEEIAKNYGKTIAQIALAWLIQKPNVV-AIPKAGRVEHLKENLKAT-EIKLSEEEMKLLD 260
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
29-321 |
2.03e-33 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 124.78 E-value: 2.03e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 29 SLGLWHNFGDEGSlknqRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASdfKPyRDEMVISSKAGYFMWDGPYG 108
Cdd:cd19162 9 SLGNLARAGEDEA----AATLDAAWDAGIRYFDTAPLYG--LGLSERRLGAALAR--HP-RAEYVVSTKVGRLLEPGAAG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 109 -------EWG-SRKYLISSLDQSLKRMGLDYVDIFYSHRPDP--NTPIEETMGALASVVQQGKALYVGISSYTPEQTLAA 178
Cdd:cd19162 80 rpagadrRFDfSADGIRRSIEASLERLGLDRLDLVFLHDPDRhlLQALTDAFPALEELRAEGVVGAIGVGVTDWAALLRA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 179 kkeLDRLGVPLLIHQPRYSMFDRTIErSGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGIPKDSRAAlgvhlgeeriNEV 258
Cdd:cd19162 160 ---ARRADVDVVMVAGRYTLLDRRAA-TELLPLCAAKGVAVVAAGVFNSGILATDDPAGDRYDYRPA----------TPE 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2676402920 259 YLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHGPdfEPEEL 321
Cdd:cd19162 226 VLARARRLAAVCRRYGVPLPAAALQFPLRHPAVASVVVGAASPAELRDNLALLRTP--IPAEF 286
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
16-309 |
2.30e-33 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 123.36 E-value: 2.30e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 16 RRSGKSGLKLPEISLGLWHNFgdEGSLKNQRAILRRAFDMGVTHFDLANNYgipaGSAESHFGDVLasdfKPYRDEMVIS 95
Cdd:cd19100 2 RRLGRTGLKVSRLGFGGGPLG--RLSQEEAAAIIRRALDLGINYFDTAPSY----GDSEEKIGKAL----KGRRDKVFLA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 96 SKAGYFMWDgpygewGSRKylisSLDQSLKRMGLDYVDIFYSH----RPDPNTPIEEtMGALASVV---QQGKALYVGIS 168
Cdd:cd19100 72 TKTGARDYE------GAKR----DLERSLKRLGTDYIDLYQLHavdtEEDLDQVFGP-GGALEALLeakEEGKIRFIGIS 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 169 SYTPEqtlAAKKELDRLGVPLLihQPRYSMFDRTI--ERSGLLYTLDEIGAGCIVFSPLSQGMLTDrylkgipkdsraal 246
Cdd:cd19100 141 GHSPE---VLLRALETGEFDVV--LFPINPAGDHIdsFREELLPLAREKGVGVIAMKVLAGGRLLS-------------- 201
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2676402920 247 gvhlgeerinevylervrglsaiaeaRGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIA 309
Cdd:cd19100 202 --------------------------GDPLDPEQALRYALSLPPVDVVIVGMDSPEELDENLA 238
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
26-310 |
4.77e-33 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 123.98 E-value: 4.77e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 26 PEISLGLWhNFGDEGSLKNQRAILRRAFDMGVTHFDLANNY-----GIPAGSAESHFGDVLASdfKPYRDEMVISSKAGy 100
Cdd:cd19752 1 SELCLGTM-YFGTRTDEETSFAILDRYVAAGGNFLDTANNYafwteGGVGGESERLIGRWLKD--RGNRDDVVIATKVG- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 101 FMWDGPYG-----EWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQT 175
Cdd:cd19752 77 AGPRDPDGgpespEGLSAETIEQEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGASNFAAWRL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 176 LAAKKELDRLGVPLLIH-QPRYSMF---------DRTIERSGLLYTLDEIGAGCIV-FSPLSQGMLTDrylkgipkDSRA 244
Cdd:cd19752 157 ERARQIARQQGWAEFSAiQQRHSYLrprpgadfgVQRIVTDELLDYASSRPDLTLLaYSPLLSGAYTR--------PDRP 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2676402920 245 ALGVHLGEEriNEVyleRVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAA 310
Cdd:cd19752 229 LPEQYDGPD--SDA---RLAVLEEVAGELGATPNQVVLAWLLHRTPAIIPLLGASTVEQLEENLAA 289
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-325 |
5.43e-33 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 124.69 E-value: 5.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 14 NFRRSGKSGLKLPEISLG------LWhnfgDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASDfkp 87
Cdd:cd19104 1 KYRRFGRTGLKVSELTFGgggiggLM----GRTTREEQIAAVRRALDLGINFFDTAPSYG--DGKSEENLGRALKGL--- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 88 yRDEMVISSKAGyfMWDGPYGEWGSRkyLISSLDQSLKRMGLDYVDIFYSH------RPDPNTPIEETMG---------A 152
Cdd:cd19104 72 -PAGPYITTKVR--LDPDDLGDIGGQ--IERSVEKSLKRLKRDSVDLLQLHnrigdeRDKPVGGTLSTTDvlglggvadA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 153 LASVVQQGKALYVGISSYTPEQTLAAKKELDRLG---VPL-LIHQP----RYSMFDRTIERsGLLYTLDEIGAGCIVFSP 224
Cdd:cd19104 147 FERLRSEGKIRFIGITGLGNPPAIRELLDSGKFDavqVYYnLLNPSaaeaRPRGWSAQDYG-GIIDAAAEHGVGVMGIRV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 225 LSQGMLTDrylkgipkDSRAALGVHLGEERINEVYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQL 304
Cdd:cd19104 226 LAAGALTT--------SLDRGREAPPTSDSDVAIDFRRAAAFRALAREWGETLAQLAHRFALSNPGVSTVLVGVKNREEL 297
|
330 340
....*....|....*....|.
gi 2676402920 305 EDNIAAIHGPDFEPEELEAID 325
Cdd:cd19104 298 EEAVAAEAAGPLPAENLARLE 318
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
15-324 |
5.45e-33 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 124.51 E-value: 5.45e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 15 FRRSGKSGLKLPEISLG---LWHNFGDEgSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASDFKPyRDE 91
Cdd:PLN02587 1 LRELGSTGLKVSSVGFGaspLGSVFGPV-SEEDAIASVREAFRLGINFFDTSPYYG--GTLSEKVLGKALKALGIP-REK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 92 MVISSKAGYfmwdgpYGEwG---SRKYLISSLDQSLKRMGLDYVDIFYSHR---PDPNTPIEETMGALASVVQQGKALYV 165
Cdd:PLN02587 77 YVVSTKCGR------YGE-GfdfSAERVTKSVDESLARLQLDYVDILHCHDiefGSLDQIVNETIPALQKLKESGKVRFI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 166 GISSYTPEqtlAAKKELDRL---GVPLLIHQPRYSMFDRTIErsGLLYTLDEIGAGCIVFSPLSQGMLTDrylKGIPKds 242
Cdd:PLN02587 150 GITGLPLA---IFTYVLDRVppgTVDVILSYCHYSLNDSSLE--DLLPYLKSKGVGVISASPLAMGLLTE---NGPPE-- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 243 raalgVHLGEERINEVylerVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAA-----IHGPDFE 317
Cdd:PLN02587 220 -----WHPAPPELKSA----CAAAATHCKEKGKNISKLALQYSLSNKDISTTLVGMNSVQQVEENVAAateleTSGIDEE 290
|
....*...
gi 2676402920 318 P-EELEAI 324
Cdd:PLN02587 291 LlSEVEAI 298
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
22-325 |
3.89e-32 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 120.44 E-value: 3.89e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWHNFGDEGslknqRAILRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKPyRDEMVISSKagyf 101
Cdd:cd19140 5 GVRIPALGLGTYPLTGEEC-----TRAVEHALELGYRHIDTAQMYG-----NEAQVGEAIAASGVP-RDELFLTTK---- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 102 MWDGPYgewgSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQTLAAKKE 181
Cdd:cd19140 70 VWPDNY----SPDDFLASVEESLRKLRTDYVDLLLLHWPNKDVPLAETLGALNEAQEAGLARHIGVSNFTVALLREAVEL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 182 ldrLGVPLLIHQPRYSMFdrtIERSGLLYTLDEIGAGCIVFSPLSQGMLTDRYLkgipkdsraalgvhlgeerinevyle 261
Cdd:cd19140 146 ---SEAPLFTNQVEYHPY---LDQRKLLDAAREHGIALTAYSPLARGEVLKDPV-------------------------- 193
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2676402920 262 rvrgLSAIAEARGQTLAQMALLWTLRNPGVtSALIGASSVKQLEDNIAAIhgpDFE--PEELEAID 325
Cdd:cd19140 194 ----LQEIGRKHGKTPAQVALRWLLQQEGV-AAIPKATNPERLEENLDIF---DFTlsDEEMARIA 251
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
21-325 |
1.88e-31 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 118.62 E-value: 1.88e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLGLWHNFGDEGslknqRAILRRAFDMGVTHFDLANNYGipagsAESHFGDVLA-SDFKpyRDEMVISSKAg 99
Cdd:COG0656 1 NGVEIPALGLGTWQLPGEEA-----AAAVRTALEAGYRHIDTAAMYG-----NEEGVGEAIAaSGVP--REELFVTTKV- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 100 yfmwdgpYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNtPIEETMGALASVVQQGKALYVGISSYTPEQtlaak 179
Cdd:COG0656 68 -------WNDNHGYDDTLAAFEESLERLGLDYLDLYLIHWPGPG-PYVETWRALEELYEEGLIRAIGVSNFDPEH----- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 180 keLDRL----GVPLLIHQ----PRYSMFDrtiersgLLYTLDEIGagcIV---FSPLSQGMLTDrylkgipkdsraalgv 248
Cdd:COG0656 135 --LEELlaetGVKPAVNQvelhPYLQQRE-------LLAFCREHG---IVveaYSPLGRGKLLD---------------- 186
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2676402920 249 hlgeeriNEVylervrgLSAIAEARGQTLAQMALLWTLRNpGVtSALIGASSVKQLEDNIAAIhgpDFE--PEELEAID 325
Cdd:COG0656 187 -------DPV-------LAEIAEKHGKTPAQVVLRWHLQR-GV-VVIPKSVTPERIRENLDAF---DFElsDEDMAAID 246
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
25-325 |
2.48e-31 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 118.14 E-value: 2.48e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 25 LPEISLGLWHNFGDEGslknqRAILRRAFDMGVTHFDLANNYGipagsAESHFGDVLAsDFKPYRDEMVISSKagyfMWd 104
Cdd:cd19073 1 IPALGLGTWQLRGDDC-----ANAVKEALELGYRHIDTAEIYN-----NEAEVGEAIA-ESGVPREDLFITTK----VW- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 105 gpYGEWGSRKyLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSYTPEQTlaaKKELDR 184
Cdd:cd19073 65 --RDHLRPED-LKKSVDRSLEKLGTDYVDLLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSNFTIELL---EEALDI 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 185 LGVPLLIHQPRYSMFdrtIERSGLLYTLDEIGAGCIVFSPLSQGmltdrylkGIPKDSRaalgvhlgeerinevylervr 264
Cdd:cd19073 139 SPLPIAVNQVEFHPF---LYQAELLEYCRENDIVITAYSPLARG--------EVLRDPV--------------------- 186
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2676402920 265 gLSAIAEARGQTLAQMALLWtLRNPGVtSALIGASSVKQLEDNIAAihgPDFE--PEELEAID 325
Cdd:cd19073 187 -IQEIAEKYDKTPAQVALRW-LVQKGI-VVIPKASSEDHLKENLAI---FDWEltSEDVAKID 243
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
23-323 |
1.76e-30 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 117.43 E-value: 1.76e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 23 LKLPEISLGLW----------HNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLasdfKPY-RDE 91
Cdd:cd19103 2 KKLPKIALGTWswgsggaggdQVFGNHLDEDTLKAVFDKAMAAGLNLWDTAAVYG--MGASEKILGEFL----KRYpRED 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 92 MVISSKagyFMwdgPYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPdpnTPIEETMGALASVVQQGKALYVGISSYT 171
Cdd:cd19103 76 YIISTK---FT---PQIAGQSADPVADMLEGSLARLGTDYIDIYWIHNP---ADVERWTPELIPLLKSGKVKHVGVSNHN 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 172 PEQTLAAKKELDRLGVPLLIHQPRYSMFDRTIERSGLLYTLDEIGagcIVFSP---LSQGMLTDRYLKGIPKDSRAALGV 248
Cdd:cd19103 147 LAEIKRANEILAKAGVSLSAVQNHYSLLYRSSEEAGILDYCKENG---ITFFAymvLEQGALSGKYDTKHPLPEGSGRAE 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2676402920 249 HLG--EERINEVYlervRGLSAIAEARGQTLAQMALLWTlRNPGVTsALIGASSVKQLED--NIAAIHGPDFEPEELEA 323
Cdd:cd19103 224 TYNplLPQLEELT----AVMAEIGAKHGASIAQVAIAWA-IAKGTT-PIIGVTKPHHVEDaaRAASITLTDDEIKELEQ 296
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
13-325 |
6.69e-30 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 117.23 E-value: 6.69e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 13 MNFRRSGKSGLKLPEISLGLWHnfGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipaGSaESHFGDVLasdfKPYRDEM 92
Cdd:COG1453 1 MQYRRLGKTGLEVSVLGFGGMR--LPRKDEEEAEALIRRAIDNGINYIDTARGYG---DS-EEFLGKAL----KGPRDKV 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 93 VISSKagyfmwDGPYGEwgSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETM---GALASVVQ---QGKALYVG 166
Cdd:COG1453 71 ILATK------LPPWVR--DPEDMRKDLEESLKRLQTDYIDLYLIHGLNTEEDLEKVLkpgGALEALEKakaEGKIRHIG 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 167 ISSYTPEQTLAAKKELDRLGVpLLIHqprYSMFDRT-IERSGLLYTLDEIGAGCIVFSPLSQGMLTDrylkgIPKDSRAA 245
Cdd:COG1453 143 FSTHGSLEVIKEAIDTGDFDF-VQLQ---YNYLDQDnQAGEEALEAAAEKGIGVIIMKPLKGGRLAN-----PPEKLVEL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 246 LGVHLgeerinevylervrglsaiaeargqTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHGPD-FEPEELEAI 324
Cdd:COG1453 214 LCPPL-------------------------SPAEWALRFLLSHPEVTTVLSGMSTPEQLDENLKTADNLEpLTEEELAIL 268
|
.
gi 2676402920 325 D 325
Cdd:COG1453 269 E 269
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
13-324 |
3.19e-29 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 114.95 E-value: 3.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 13 MNFRRSGKSGLKLPEISLGLWhNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGIPA-----GSAESHFGDVLASdfKP 87
Cdd:PRK10625 1 MQYHRIPHSSLEVSTLGLGTM-TFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPrpetqGLTETYIGNWLAK--RG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 88 YRDEMVISSKAGyfmwdGPYGEWGS---------RKYLISSLDQSLKRMGLDYVDIFYSHRPD----------------- 141
Cdd:PRK10625 78 SREKLIIASKVS-----GPSRNNDKgirpnqaldRKNIREALHDSLKRLQTDYLDLYQVHWPQrptncfgklgyswtdsa 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 142 PNTPIEETMGALASVVQQGKALYVGISSYTPEQT-----LAAKKELDRLgvpLLIHQPrYSMFDRTIErSGLLYTLDEIG 216
Cdd:PRK10625 153 PAVSLLETLDALAEQQRAGKIRYIGVSNETAFGVmrylhLAEKHDLPRI---VTIQNP-YSLLNRSFE-VGLAEVSQYEG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 217 AGCIVFSPLSQGMLTDRYLKGI-PKDSRAALG---VHLGEERINEVYLERVrglsAIAEARGQTLAQMALLWTLRNPGVT 292
Cdd:PRK10625 228 VELLAYSCLAFGTLTGKYLNGAkPAGARNTLFsrfTRYSGEQTQKAVAAYV----DIAKRHGLDPAQMALAFVRRQPFVA 303
|
330 340 350
....*....|....*....|....*....|....
gi 2676402920 293 SALIGASSVKQLEDNIAAIHGPDFEP--EELEAI 324
Cdd:PRK10625 304 STLLGATTMEQLKTNIESLHLTLSEEvlAEIEAV 337
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
21-329 |
5.91e-28 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 110.98 E-value: 5.91e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLG-LWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYgiPAGSAESHFGDVLASdfKPYRDEMVISSK-- 97
Cdd:cd19146 12 SPLCLGAMSFGeAWKSMMGECDKETAFKLLDAFYEQGGNFIDTANNY--QGEESERWVGEWMAS--RGNRDEMVLATKyt 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 98 AGYFMWDGP-----YGEwGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSyTP 172
Cdd:cd19146 88 TGYRRGGPIkiksnYQG-NHAKSLRLSVEASLKKLQTSYIDILYVHWWDYTTSIPELMQSLNHLVAAGKVLYLGVSD-TP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 173 EQTLAAKKELDRLGV--PLLIHQPRYSMFDRTIERSGLLYTLDEiGAGCIVFSPLSQGMLTdrylkgIPKDSRAALGVHL 250
Cdd:cd19146 166 AWVVSKANAYARAHGltQFVVYQGHWSAAFRDFERDILPMCEAE-GMALAPWGVLGQGQFR------TEEEFKRRGRSGR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 251 GEERINEVYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHG--PDFEPEELEAIDVFA 328
Cdd:cd19146 239 KGGPQTEKERKVSEKLEKVAEEKGTAITSVALAYVMHKAPYVFPIVGGRKVEHLKGNIEALGIslSDEEIQEIEDAYPFD 318
|
.
gi 2676402920 329 V 329
Cdd:cd19146 319 V 319
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
23-309 |
3.11e-27 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 108.94 E-value: 3.11e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 23 LKLPEISLGLWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLA---SDFKPYRDEMVISSKAG 99
Cdd:cd19099 1 LTLSSLGLGTYRGDSDDETDEEYREALKAALDSGINVIDTAINYR--GGRSERLIGKALReliEKGGIKRDEVVIVTKAG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 100 Y--FMWDGPYGEWGSR-----------------------KYLISSLDQSLKRMGLDYVDIFYSHRP----------DPNT 144
Cdd:cd19099 79 YipGDGDEPLRPLKYLeeklgrglidvadsaglrhcispAYLEDQIERSLKRLGLDTIDLYLLHNPeeqllelgeeEFYD 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 145 PIEETMGALASVVQQGKALYVGISSYTPEQTLAAKKELDRLG--------------------VPLLIHQPrySMFDRTIE 204
Cdd:cd19099 159 RLEEAFEALEEAVAEGKIRYYGISTWDGFRAPPALPGHLSLEklvaaaeevggdnhhfkviqLPLNLLEP--EALTEKNT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 205 RSGLLYTL----DEIGAGCIVFSPLSQGMLtdrylkgipkdsraalgvhlgeerinevyLERVRGLSAIAEARGQTLAQM 280
Cdd:cd19099 237 VKGEALSLleaaKELGLGVIASRPLNQGQL-----------------------------LGELRLADLLALPGGATLAQR 287
|
330 340
....*....|....*....|....*....
gi 2676402920 281 ALLWTLRNPGVTSALIGASSVKQLEDNIA 309
Cdd:cd19099 288 ALQFARSTPGVDSALVGMRRPEHVDENLA 316
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
46-311 |
4.78e-26 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 104.53 E-value: 4.78e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 46 RAILRRAFDMGVTHFDLANNYGipagSAESHFGDVLASDfkpyrDEMVISSKAGYFMWDGPYgewgSRKYLISSLDQSLK 125
Cdd:cd19097 29 KKILEYALKAGINTLDTAPAYG----DSEKVLGKFLKRL-----DKFKIITKLPPLKEDKKE----DEAAIEASVEASLK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 126 RMGLDYVDIFYSHRPD----PNTPIEEtmgALASVVQQGKALYVGISSYTPEQtlaAKKELDRlGVPLLIHQPrYSMFDR 201
Cdd:cd19097 96 RLKVDSLDGLLLHNPDdllkHGGKLVE---ALLELKKEGLIRKIGVSVYSPEE---LEKALES-FKIDIIQLP-FNILDQ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 202 TIERSGLLYTLDEIGAGCIVFSPLSQGMLTDRYLKgIPKDSRAAlgvhlgeerinEVYLERVRglsAIAEARGQTLAQMA 281
Cdd:cd19097 168 RFLKSGLLAKLKKKGIEIHARSVFLQGLLLMEPDK-LPAKFAPA-----------KPLLKKLH---ELAKKLGLSPLELA 232
|
250 260 270
....*....|....*....|....*....|
gi 2676402920 282 LLWTLRNPGVTSALIGASSVKQLEDNIAAI 311
Cdd:cd19097 233 LGFVLSLPEIDKIVVGVDSLEQLKEIIAAF 262
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
31-328 |
3.02e-23 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 97.67 E-value: 3.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 31 GLWHNFGDEGSLKNQRAILR---RAFDMGVTHFDLANNYGipagSAESHFGDVLAS--DFKPYRDEMVISSKAGYFmwdg 105
Cdd:cd19101 8 GMWQLSGGHGGIRDEDAAVRamaAYVDAGLTTFDCADIYG----PAEELIGEFRKRlrRERDAADDVQIHTKWVPD---- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 106 PYGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTP-IEETMGALASVVQQGKALYVGISSYTPEQTlaakKELDR 184
Cdd:cd19101 80 PGELTMTRAYVEAAIDRSLKRLGVDRLDLVQFHWWDYSDPgYLDAAKHLAELQEEGKIRHLGLTNFDTERL----REILD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 185 LGVPLLIHQPRYSMFDRTIERSGLLYTLDEiGAGCIVFSPLSQGMLTDRYLkGIPKDSRAALG------------VHLGE 252
Cdd:cd19101 156 AGVPIVSNQVQYSLLDRRPENGMAALCEDH-GIKLLAYGTLAGGLLSEKYL-GVPEPTGPALEtrslqkyklmidEWGGW 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2676402920 253 ERinevYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNiAAIHGPDFEPEELEAIDVFA 328
Cdd:cd19101 234 DL----FQELLRTLKAIADKHGVSIANVAVRWVLDQPGVAGVIVGARNSEHIDDN-VRAFSFRLDDEDRAAIDAVL 304
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
21-325 |
8.36e-23 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 96.82 E-value: 8.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLG-LWHNFgdEGSLKNQRA--ILRRAFDMGVTHFDLANNYgiPAGSAESHFGDVLASdfKPYRDEMVISSK 97
Cdd:cd19147 11 SPLILGAMSIGdAWSGF--MGSMDKEQAfeLLDAFYEAGGNFIDTANNY--QDEQSETWIGEWMKS--RKNRDQIVIATK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 98 AGYFMWDGPYGE------WG-SRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEETMGALASVVQQGKALYVGISSy 170
Cdd:cd19147 85 FTTDYKAYEVGKgkavnyCGnHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKVLYLGVSD- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 171 TPEQTLAAKKELDRL--GVPLLIHQPRYSMFDRTIERSGL---------LYTLDEIGAGCIvfspLSQGMLTDRYLKGIP 239
Cdd:cd19147 164 TPAWVVSAANYYATAhgKTPFSVYQGRWNVLNRDFERDIIpmarhfgmaLAPWDVLGGGKF----QSKKAVEERKKNGEG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 240 KDSraalGVHLGEERINEVYLErvRGLSAIAEARG-QTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIhGPDFEP 318
Cdd:cd19147 240 LRS----FVGGTEQTPEEVKIS--EALEKVAEEHGtESVTAIALAYVRSKAPNVFPLVGGRKIEHLKDNIEAL-SIKLTP 312
|
....*..
gi 2676402920 319 EELEAID 325
Cdd:cd19147 313 EEIEYLE 319
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
31-312 |
1.52e-22 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 95.75 E-value: 1.52e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 31 GLWHNFGDEGSLknqrAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASdfKPyRDEMVISSKAGYFM-------- 102
Cdd:cd19152 12 NLYEAVSDEEAK----ATLVAAWDLGIRYFDTAPWYG--AGLSEERLGAALRE--LG-REDYVISTKVGRLLvplqevep 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 103 -----WDGP--------YGEWGSRKylisSLDQSLKRMGLDYVDIFYSHRPDPNTPIEET-----------MGALASVVQ 158
Cdd:cd19152 83 tfepgFWNPlpfdavfdYSYDGILR----SIEDSLQRLGLSRIDLLSIHDPDEDLAGAESdehfaqaikgaFRALEELRE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 159 QGKALYVGISSYTPEqtlAAKKELDRLGVPLLIHQPRYSMFDRTIERSgLLYTLDEIGAGCIVFSPLSQGMLTDRYLKGI 238
Cdd:cd19152 159 EGVIKAIGLGVNDWE---VILRILEEADLDWVMLAGRYTLLDHSAARE-LLPECEKRGVKVVNAGPFNSGFLAGGDNFDY 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2676402920 239 PKDSRAalgvhlgeeriNEVYLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIH 312
Cdd:cd19152 235 YEYGPA-----------PPELIARRDRIEALCEQHGVSLAAAALQFALAPPAVASVAPGASSPERVEENVALLA 297
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
37-318 |
7.82e-22 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 92.62 E-value: 7.82e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 37 GDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLAsdfKPYRDEMVISSKAGYfmWDGPYGEwGSRKYl 116
Cdd:cd19096 15 DDSIDEEKAIEMIRYAIDAGINYFDTAYGYG--GGKSEEILGEALK---EGPREKFYLATKLPP--WSVKSAE-DFRRI- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 117 issLDQSLKRMGLDYVDIFYSHrpDPNTP-IEETMGALASV------VQQGKALYVGISSYTPEQTLAAKKELDRL-GVp 188
Cdd:cd19096 86 ---LEESLKRLGVDYIDFYLLH--GLNSPeWLEKARKGGLLeflekaKKEGLIRHIGFSFHDSPELLKEILDSYDFdFV- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 189 lLIHqprYSMFDRTIERSGLLYTL-DEIGAGCIVFSPLSQGMLTDRylkgiPKDSRAALgvhlgeerinevylervrgls 267
Cdd:cd19096 160 -QLQ---YNYLDQENQAGRPGIEYaAKKGMGVIIMEPLKGGGLANN-----PPEALAIL--------------------- 209
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 2676402920 268 aiaEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAihGPDFEP 318
Cdd:cd19096 210 ---CGAPLSPAEWALRFLLSHPEVTTVLSGMSTPEQLDENIAA--ADEFEP 255
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
26-312 |
6.49e-20 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 88.54 E-value: 6.49e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 26 PEISLG------LWHNFgdegSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASdfKPyRDEMVISSKAG 99
Cdd:cd19161 1 SELGLGtaglgnLYTAV----SNADADATLDAAWDSGIRYFDTAPMYG--HGLAEHRLGDFLRE--KP-RDEFVLSTKVG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 100 YFMW---DG---PYGEWG-----------SRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIEE--------TMG--- 151
Cdd:cd19161 72 RLLKparEGsvpDPNGFVdplpfeivydySYDGIMRSFEDSLQRLGLNRIDILYVHDIGVYTHGDRkerhhfaqLMSggf 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 152 -ALASVVQQGKALYVGISSYTPEQTLAAkkeLDRLGVPLLIHQPRYSMFDRTIErSGLLYTLDEIGAGCIVFSPLSQGML 230
Cdd:cd19161 152 kALEELKKAGVIKAFGLGVNEVQICLEA---LDEADLDCFLLAGRYSLLDQSAE-EEFLPRCEQRGTSLVIGGVFNSGIL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 231 TDrylkgiPKDSRAALGVHLGEERInevyLERVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAA 310
Cdd:cd19161 228 AT------GTKSGAKFNYGDAPAEI----ISRVMEIEKICDAYNVPLAAAALQFPLRHPAVASVLTGARNPAQLRQNVEA 297
|
..
gi 2676402920 311 IH 312
Cdd:cd19161 298 FQ 299
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
16-314 |
3.42e-19 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 86.44 E-value: 3.42e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 16 RRSGKSGLKLPEISLG---LWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYGipAGSAESHFGDVLASDFKPyRDEM 92
Cdd:cd19153 3 ETLEIALGNVSPVGLGtaaLGGVYGDGLEQDEAVAIVAEAFAAGINHFDTSPYYG--AESSEAVLGKALAALQVP-RSSY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 93 VISSKAGYfmwdgpYGEWG---SRKYLISSLDQSLKRMGLDYVDIFYSHR---PDPNTPIEETMGALASVVQQGKALYVG 166
Cdd:cd19153 80 TVATKVGR------YRDSEfdySAERVRASVATSLERLHTTYLDVVYLHDiefVDYDTLVDEALPALRTLKDEGVIKRIG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 167 ISSYtPEQTLAAKKELDRLGVPLLIHQ-PRYSMFDRTIErSGLLYTLDEIGAGCIVFSPLSQGMLTDRY------LKGIP 239
Cdd:cd19153 154 IAGY-PLDTLTRATRRCSPGSLDAVLSyCHLTLQDARLE-SDAPGLVRGAGPHVINASPLSMGLLTSQGpppwhpASGEL 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2676402920 240 KDSRAAlgvhlgeerinevylervrgLSAIAEARGQTLAQMALLWTLRN-PGVTSALIGASSVKQLEDNIAAIHGP 314
Cdd:cd19153 232 RHYAAA--------------------ADAVCASVEASLPDLALQYSLAAhAGVGTVLLGPSSLAQLRSMLAAVDAV 287
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
25-325 |
1.29e-18 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 83.69 E-value: 1.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 25 LPEISLGLWHNFGDEGslknqRAILRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKPyRDEMVISSKagyfMWD 104
Cdd:cd19071 1 MPLIGLGTYKLKPEET-----AEAVLAALEAGYRHIDTAAAYG-----NEAEVGEAIRESGVP-REELFITTK----LWP 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 105 GPYGEWGSRKylisSLDQSLKRMGLDYVDIFYSHRPDPN------TPIEETMGALASVVQQGKALYVGISSYTPEQtlaa 178
Cdd:cd19071 66 TDHGYERVRE----ALEESLKDLGLDYLDLYLIHWPVPGkeggskEARLETWRALEELVDEGLVRSIGVSNFNVEH---- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 179 kkeLDRL----GVPLLIHQprysmfdrtIERSgLLYTLDEIGAGC----IV---FSPLSQGMLTDrylkgipkdsraalg 247
Cdd:cd19071 138 ---LEELlaaaRIKPAVNQ---------IELH-PYLQQKELVEFCkehgIVvqaYSPLGRGRRPL--------------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 248 vhLGEERINEvylervrglsaIAEARGQTLAQMALLWTLRNpGVtSALIGASSVKQLEDNIAAIhgpDFE--PEELEAID 325
Cdd:cd19071 190 --LDDPVLKE-----------IAKKYGKTPAQVLLRWALQR-GV-VVIPKSSNPERIKENLDVF---DFElsEEDMAAID 251
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
25-325 |
3.51e-17 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 79.70 E-value: 3.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 25 LPEISLGLWHNFGDEGslknqRAILRRAFDMGVTHFDLANNYGipagsAESHFGDVLAsDFKPYRDEMVISSKagyfMWD 104
Cdd:cd19139 1 IPAFGLGTFRLKDDVV-----IDSVRTALELGYRHIDTAQIYD-----NEAAVGQAIA-ESGVPRDELFITTK----IWI 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 105 GPYgewgSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPN--TPIEETMGALASVVQQGKALYVGISSYTPEQTLAAKKEL 182
Cdd:cd19139 66 DNL----SKDKLLPSLEESLEKLRTDYVDLTLIHWPSPNdeVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEAIAVV 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 183 DrlGVPLLIHQPRYSMFdrtIERSGLLYTLDEIGAGCIVFSPLSQGMLTDrylkgipkdsraalgvhlgeeriNEVyler 262
Cdd:cd19139 142 G--AGAIATNQIELSPY---LQNRKLVAHCKQHGIHVTSYMTLAYGKVLD-----------------------DPV---- 189
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2676402920 263 vrgLSAIAEARGQTLAQMALLWTLrnpGVTSALIGASSVKQ-LEDNIAAiHGPDFEPEELEAID 325
Cdd:cd19139 190 ---LAAIAERHGATPAQIALAWAM---ARGYAVIPSSTKREhLRSNLLA-LDLTLDADDMAAIA 246
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
42-310 |
7.13e-17 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 79.30 E-value: 7.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 42 LKNQRAI--LRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKPyRDEMVISSKagyfMWDGPYgewgSRKYLISS 119
Cdd:PRK11172 13 LKDQVVIdsVKTALELGYRAIDTAQIYD-----NEAAVGQAIAESGVP-RDELFITTK----IWIDNL----AKDKLIPS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 120 LDQSLKRMGLDYVDIFYSHRPDPN--TPIEETMGALASVVQQGKALYVGISSYTPEQTlaaKKELDRLGVpllihqprys 197
Cdd:PRK11172 79 LKESLQKLRTDYVDLTLIHWPSPNdeVSVEEFMQALLEAKKQGLTREIGISNFTIALM---KQAIAAVGA---------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 198 mfdrtiersgllytlDEIGAGCIVFSPLSQGMLTDRYLK--GIPKDSRAALGVhlGEERINEVylervrgLSAIAEARGQ 275
Cdd:PRK11172 146 ---------------ENIATNQIELSPYLQNRKVVAFAKehGIHVTSYMTLAY--GKVLKDPV-------IARIAAKHNA 201
|
250 260 270
....*....|....*....|....*....|....*..
gi 2676402920 276 TLAQMALLWTLrnpGVTSALIgASSVKQ--LEDNIAA 310
Cdd:PRK11172 202 TPAQVILAWAM---QLGYSVI-PSSTKRenLASNLLA 234
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
25-312 |
1.51e-15 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 75.78 E-value: 1.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 25 LPEISLG---LWHNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYgipaGSAESHFGDVLASDFKPY-RDEMVISSKAG- 99
Cdd:cd19164 13 LPPLIFGaatFSYQYTTDPESIPPVDIVRRALELGIRAFDTSPYY----GPSEIILGRALKALRDEFpRDTYFIITKVGr 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 100 YFMWDGPYgewgSRKYLISSLDQSLKRMGLDYVDIFYSHrpDPN-TPIEETMGALASVVQ---QGKALYVGISSYtPEQT 175
Cdd:cd19164 89 YGPDDFDY----SPEWIRASVERSLRRLHTDYLDLVYLH--DVEfVADEEVLEALKELFKlkdEGKIRNVGISGY-PLPV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 176 LA--AKKELDRLGVPL-LIHQprYSMFdrTIERSGLLYTLDEI-GAGCIVF----SPLSQGMLTDRylkGIPK------D 241
Cdd:cd19164 162 LLrlAELARTTAGRPLdAVLS--YCHY--TLQNTTLLAYIPKFlAAAGVKVvlnaSPLSMGLLRSQ---GPPEwhpaspE 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2676402920 242 SRAAlgvhlgeerinevylerVRGLSAIAEARGQTLAQMALLWTLR-NPGVTSALIGASSVKQLEDNIAAIH 312
Cdd:cd19164 235 LRAA-----------------AAKAAEYCQAKGTDLADVALRYALReWGGEGPTVVGCSNVDELEEAVEAYW 289
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
46-324 |
1.54e-15 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 75.78 E-value: 1.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 46 RAILRRAFDMGVTHFDLANNYGipagsaeSHFGDVLASD-FKPYRDEMVISSKAGYFMwdGPYGEWG---SRKYLISSLD 121
Cdd:PRK10376 43 IAVLREAVALGVNHIDTSDFYG-------PHVTNQLIREaLHPYPDDLTIVTKVGARR--GEDGSWLpafSPAELRRAVH 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 122 QSLKRMGLDYVDI------FYSHRPDPNtPIEETMGALASVVQQGKALYVGISSYTPEQTLAAKKELDRLGVpllihQPR 195
Cdd:PRK10376 114 DNLRNLGLDVLDVvnlrlmGDGHGPAEG-SIEEPLTVLAELQRQGLVRHIGLSNVTPTQVAEARKIAEIVCV-----QNH 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 196 YSMFDRTIErsGLLYTLDEIGAGCIVFSPLsqGMLTdrylkgiPKDSRAalgvhlgeerinevylervrgLSAIAEARGQ 275
Cdd:PRK10376 188 YNLAHRADD--ALIDALARDGIAYVPFFPL--GGFT-------PLQSST---------------------LSDVAASLGA 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 2676402920 276 TLAQMALLWTL-RNPGVTsaLI-GASSVKQLEDNIAA--IHGPDFEPEELEAI 324
Cdd:PRK10376 236 TPMQVALAWLLqRSPNIL--LIpGTSSVAHLRENLAAaeLVLSEEVLAELDGI 286
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
22-324 |
1.27e-13 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 69.71 E-value: 1.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWHNFGDEGslknqRAILRRAFDMGVTHFDLANNYGIPAGsaeshFGDVLASDFKPyRDEMVISSKagyf 101
Cdd:cd19131 7 GNTIPQLGLGVWQVSNDEA-----ASAVREALEVGYRSIDTAAIYGNEEG-----VGKAIRASGVP-REELFITTK---- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 102 MWDGPYGEWGSRKylisSLDQSLKRMGLDYVDIFYSHRPDPNT-PIEETMGALASVVQQGKALYVGISSYTPE--QTLaa 178
Cdd:cd19131 72 LWNSDQGYDSTLR----AFDESLRKLGLDYVDLYLIHWPVPAQdKYVETWKALIELKKEGRVKSIGVSNFTIEhlQRL-- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 179 kkeLDRLGVPLLIHQprysmfdrtIERSGLLyTLDEIGAGC----IV---FSPLSQGMLtdrylkgipkdsraalgvhLG 251
Cdd:cd19131 146 ---IDETGVVPVVNQ---------IELHPRF-QQRELRAFHakhgIQtesWSPLGQGGL-------------------LS 193
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2676402920 252 EERINEvylervrglsaIAEARGQTLAQMALLWTLRNPGVtsaLIGAS-SVKQLEDNIAAIhgpDFE--PEELEAI 324
Cdd:cd19131 194 DPVIGE-----------IAEKHGKTPAQVVIRWHLQNGLV---VIPKSvTPSRIAENFDVF---DFEldADDMQAI 252
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
21-324 |
4.02e-13 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 69.05 E-value: 4.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLGLWHnfGDEGSLKNqraILRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKP---YRDEMVISSK 97
Cdd:cd19112 7 SGHKMPVIGLGVWR--MEPGEIKE---LILNAIKIGYRHFDCAADYK-----NEKEVGEALAEAFKTglvKREDLFITTK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 98 agyfMWDGPYGewgsrkYLISSLDQSLKRMGLDYVDIFYSHRPDPNTpiEETMGALASVVQQGKALYVGISSyTPEQTLA 177
Cdd:cd19112 77 ----LWNSDHG------HVIEACKDSLKKLQLDYLDLYLVHFPVATK--HTGVGTTGSALGEDGVLDIDVTI-SLETTWH 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 178 AKKELDRLGVPLLIHQPRYSMFdrtIERSGLLYTLDEIGAGCIVFSPLSQgmlTDRYLK-----GIPKDSRAALGVHLG- 251
Cdd:cd19112 144 AMEKLVSAGLVRSIGISNYDIF---LTRDCLAYSKIKPAVNQIETHPYFQ---RDSLVKfcqkhGISVTAHTPLGGAAAn 217
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2676402920 252 EERINEVYLERVRGLSAIAEARGQTLAQMALLWTL-RNpgvTSALIGASSVKQLEDNIAAIhgpDFE--PEELEAI 324
Cdd:cd19112 218 AEWFGSVSPLDDPVLKDLAKKYGKSAAQIVLRWGIqRN---TAVIPKSSKPERLKENIDVF---DFQlsKEDMKLI 287
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
22-325 |
3.83e-12 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 65.72 E-value: 3.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGL--WHNFGDEGSLknQRAI---LRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKPyRDEMVISS 96
Cdd:cd19120 1 GSKIPAIAFGTgtAWYKSGDDDI--QRDLvdsVKLALKAGFRHIDTAEMYG-----NEKEVGEALKESGVP-REDLFITT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 97 KAGYFMWDGPygewgsrkyliSSLDQSLKRMGLDYVDIFYSHRP----DPNTPIEETMGALASVVQQGKALYVGISSYTP 172
Cdd:cd19120 73 KVSPGIKDPR-----------EALRKSLAKLGVDYVDLYLIHSPffakEGGPTLAEAWAELEALKDAGLVRSIGVSNFRI 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 173 EQTlaaKKELDRLGVPLLIHQprysmfdrtIERSGLLYTLDEigaGCIVFSPlSQGMLTDRY--LKGIPKDSRAALgvhl 250
Cdd:cd19120 142 EDL---EELLDTAKIKPAVNQ---------IEFHPYLYPQQP---ALLEYCR-EHGIVVSAYspLSPLTRDAGGPL---- 201
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2676402920 251 geeriNEVylervrgLSAIAEARGQTLAQMALLWTL-RNPGVTSaligASSVKQLEDNIAAIHGPDFEPEELEAID 325
Cdd:cd19120 202 -----DPV-------LEKIAEKYGVTPAQVLLRWALqKGIVVVT----TSSKEERMKEYLEAFDFELTEEEVEEID 261
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
22-325 |
4.81e-12 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 65.32 E-value: 4.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWhNFGDEGSlknQRAIlRRAFDMGVTHFDLANNYGIPAGSAEShfgdVLASDFKpyRDEMVISSKagyf 101
Cdd:cd19130 7 GNSIPQLGYGVF-KVPPADT---QRAV-ATALEVGYRHIDTAAIYGNEEGVGAA----IAASGIP--RDELFVTTK---- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 102 MWDGPYGEWGSRkyliSSLDQSLKRMGLDYVDIFYSHRPDPNTPIE-ETMGALASVVQQGKALYVGISSYTPEQtlaakk 180
Cdd:cd19130 72 LWNDRHDGDEPA----AAFAESLAKLGLDQVDLYLVHWPTPAAGNYvHTWEAMIELRAAGRTRSIGVSNFLPPH------ 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 181 eLDRL----GVPLLIHQ----PRYSmfDRTIERSGLLYTLdEIGAgcivFSPLSQGMLTDRYLkgipkdsraalgvhlge 252
Cdd:cd19130 142 -LERIvaatGVVPAVNQielhPAYQ--QRTIRDWAQAHDV-KIEA----WSPLGQGKLLGDPP----------------- 196
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2676402920 253 erinevylervrgLSAIAEARGQTLAQMALLWTLRNPGVTsaLIGASSVKQLEDNiAAIHGPDFEPEELEAID 325
Cdd:cd19130 197 -------------VGAIAAAHGKTPAQIVLRWHLQKGHVV--FPKSVRRERMEDN-LDVFDFDLTDTEIAAID 253
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
21-327 |
6.69e-12 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 65.00 E-value: 6.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLGLWHNFGDEGSlknqRAILRRAFDMGVTHFDLANNYGIpagsaESHFGDVLASDFKP---YRDEMVISSK 97
Cdd:cd19116 7 DGNEIPAIALGTWKLKDDEGV----RQAVKHAIEAGYRHIDTAYLYGN-----EAEVGEAIREKIAEgvvKREDLFITTK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 98 agyfMWdgpyGEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRP-------DPNTPIE---------ETMGALASVVQQGK 161
Cdd:cd19116 78 ----LW----NSYHEREQVEPALRESLKRLGLDYVDLYLIHWPvafkennDSESNGDgslsdidylETWRGMEDLVKLGL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 162 ALYVGISSYTPEQTlaaKKELDRLGVPLLIHQprysmfdrtIERSgLLYTLDEIGAGC----IV---FSPLsqgmltdry 234
Cdd:cd19116 150 TRSIGVSNFNSEQI---NRLLSNCNIKPAVNQ---------IEVH-PTLTQEKLVAYCqsngIVvmaYSPF--------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 235 lkGIPKDSRAalgvHLGEERINEvylervRGLSAIAEARGQTLAQMALLWtLRNPGVTSalIGASSVKQ-LEDNIAAIhg 313
Cdd:cd19116 208 --GRLVPRGQ----TNPPPRLDD------PTLVAIAKKYGKTTAQIVLRY-LIDRGVVP--IPKSSNKKrIKENIDIF-- 270
|
330
....*....|....*.
gi 2676402920 314 pDFE--PEELEAIDVF 327
Cdd:cd19116 271 -DFQltPEEVAALNSF 285
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
21-292 |
1.07e-11 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 64.27 E-value: 1.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLGLWHNFGdegslKNQRAILRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKPyRDEMVISSKagy 100
Cdd:cd19135 9 NGVEMPILGLGTSHSGG-----YSHEAVVYALKECGYRHIDTAKRYG-----CEELLGKAIKESGVP-REDLFLTTK--- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 101 fMWdgpYGEWGSRKyLISSLDQSLKRMGLDYVDIFYSHRPDPNTP-------IEETMGALASVVQQGKALYVGISSYTPE 173
Cdd:cd19135 75 -LW---PSDYGYES-TKQAFEASLKRLGVDYLDLYLLHWPDCPSSgknvketRAETWRALEELYDEGLCRAIGVSNFLIE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 174 qtlaakkELDRL----GVPLLIHQPRYSMFDRTIErsgLLYTLDEIGagcIVF---SPLSQGMLtdrylkgipkdsraal 246
Cdd:cd19135 150 -------HLEQLledcSVVPHVNQVEFHPFQNPVE---LIEYCRDNN---IVFegyCPLAKGKA---------------- 200
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2676402920 247 gvhLGEERINEvylervrglsaIAEARGQTLAQMALLWTLRNPGVT 292
Cdd:cd19135 201 ---LEEPTVTE-----------LAKKYQKTPAQILIRWSIQNGVVT 232
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
22-325 |
5.57e-11 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 61.90 E-value: 5.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWHNFGDEGSlknqRAILRrAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKPyRDEMVISSKAgyf 101
Cdd:cd19132 4 GTQIPAIGFGTYPLKGDEGV----EAVVA-ALQAGYRLLDTAFNYE-----NEGAVGEAVRRSGVP-REELFVTTKL--- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 102 mwdgPYGEWGSRKYLiSSLDQSLKRMGLDYVDIFYSHRPDPNTPIE-ETMGALASVVQQGKALYVGISSYTPEQtlaakk 180
Cdd:cd19132 70 ----PGRHHGYEEAL-RTIEESLYRLGLDYVDLYLIHWPNPSRDLYvEAWQALIEAREEGLVRSIGVSNFLPEH------ 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 181 eLDRL----GVPLLIHQPR-YSMFDRTIERSGllytLDEIGagcIV---FSPLSQGM--LTDRYLKgipkdsraalgvhl 250
Cdd:cd19132 139 -LDRLidetGVTPAVNQIElHPYFPQAEQRAY----HREHG---IVtqsWSPLGRGSglLDEPVIK-------------- 196
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2676402920 251 geerinevylervrglsAIAEARGQTLAQMALLWTLRNpGVTSALIGASSVKQLEdNIAAIhgpDFE--PEELEAID 325
Cdd:cd19132 197 -----------------AIAEKHGKTPAQVVLRWHVQL-GVVPIPKSANPERQRE-NLAIF---DFElsDEDMAAIA 251
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
21-328 |
7.62e-11 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 61.87 E-value: 7.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLGlwhNFGDEGSLKNQRAILRRAFDMGVTHFDLANNYgIPAGSAESHFGDVLASDFKPYRDEMVISSKagy 100
Cdd:cd19122 5 NGVKIPAVGFG---TFANEGAKGETYAAVTKALDVGYRHLDCAWFY-LNEDEVGDAVRDFLKENPSVKREDLFICTK--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 101 fMWDGPYgEWGSRKYlisSLDQSLKRMGLDYVDIFYSHRP------DPNTPI-----------------EETMGALASVV 157
Cdd:cd19122 78 -VWNHLH-EPEDVKW---SIDNSLKNLKLDYIDLFLVHWPiaaeknDQRSPKlgpdgkyvilkdltenpEPTWRAMEEIY 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 158 QQGKALYVGISSYTPEqtlAAKKELDRLGVPLLIHQPRYSMFDRTIERSGLLYTLDEIGAGcivFSPL-SQGMltdrylk 236
Cdd:cd19122 153 ESGKAKAIGVSNWTIP---GLKKLLSFAKVKPHVNQIEIHPFLPNEELVDYCFSNDILPEA---YSPLgSQNQ------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 237 gIPKDSraalgvhlgeERINEvylerVRGLSAIAEARGQTLAQMALLWTLRNPGVTsaLIGASSVKQLEDNIAAIhgpDF 316
Cdd:cd19122 220 -VPSTG----------ERVSE-----NPTLNEVAEKGGYSLAQVLIAWGLRRGYVV--LPKSSTPSRIESNFKSI---EL 278
|
330
....*....|..
gi 2676402920 317 EPEELEAIDVFA 328
Cdd:cd19122 279 SDEDFEAINQVA 290
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
28-312 |
8.62e-11 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 61.98 E-value: 8.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 28 ISLGLWHNFGDEGSLKNQRA----ILRRAFDMGVTHFDLANNYGipagSAESHFGDVLASDfKPYRDEMVISSKAGYFM- 102
Cdd:cd19098 16 INLGHAADLGSGRSVEAMRAhthaVLDAAWAAGVRYFDAARSYG----RAEEFLGSWLRSR-NIAPDAVFVGSKWGYTYt 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 103 --W--DGPYGEWG--SRKYLISSLDQSLKRMGlDYVDIFYSHRPDPNTPI---EETMGALASVVQQGKAlyVGISSYTPE 173
Cdd:cd19098 91 adWqvDAAVHEVKdhSLARLLKQWEETRSLLG-KHLDLYQIHSATLESGVledADVLAALAELKAEGVK--IGLSLSGPQ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 174 Q--TLAAKKELDRLGVPLL-IHQPRYSMFDRTIerSGLLYTLDEIGAGCIVFSPLSQGMLTDRylkgIPKDSRAALgvhl 250
Cdd:cd19098 168 QaeTLRRALEIEIDGARLFdSVQATWNLLEQSA--GEALEEAHEAGMGVIVKEALANGRLTDR----NPSPELAPL---- 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2676402920 251 geerinevylerVRGLSAIAEARGQTLAQMALLWTLRNPGVTSALIGASSVKQLEDNIAAIH 312
Cdd:cd19098 238 ------------MAVLKAVADRLGVTPDALALAAVLAQPFVDVVLSGAATPEQLRSNLRALD 287
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
22-174 |
1.24e-10 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 61.36 E-value: 1.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWHNFGDEgslknQRAILRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDF---KPYRDEMVISSKA 98
Cdd:cd19111 1 GFPMPVIGLGTYQSPPEE-----VRAAVDYALFVGYRHIDTALSYQ-----NEKAIGEALKWWLkngKLKREEVFITTKL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 99 gyfmWdgPYGEwgSRKYLISSLDQSLKRMGLDYVDIFYSH-------------RPDPNTPIEETMGALASVVQQGKALYV 165
Cdd:cd19111 71 ----P--PVYL--EFKDTEKSLEKSLENLKLPYVDLYLIHhpcgfvnkkdkgeRELASSDVTSVWRAMEALVSEGKVKSI 142
|
....*....
gi 2676402920 166 GISSYTPEQ 174
Cdd:cd19111 143 GLSNFNPRQ 151
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
20-174 |
1.58e-10 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 61.27 E-value: 1.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 20 KSGLKLPEISLGLWHNFGDEGslknqRAILRRAFDMGVTHFDLANNYgipagSAESHFGDVLASDF---KPYRDEMVISS 96
Cdd:cd19154 7 SNGVKMPLIGLGTWQSKGAEG-----ITAVRTALKAGYRLIDTAFLY-----QNEEAIGEALAELLeegVVKREDLFITT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 97 KAGyFMWDGPygewGSRKYlisSLDQSLKRMGLDYVDIFYSHRP-------------------DPNTPIEETMGALASVV 157
Cdd:cd19154 77 KLW-THEHAP----EDVEE---ALRESLKKLQLEYVDLYLIHAPaafkddegesgtmengmsiHDAVDVEDVWRGMEKVY 148
|
170
....*....|....*..
gi 2676402920 158 QQGKALYVGISSYTPEQ 174
Cdd:cd19154 149 DEGLTKAIGVSNFNNDQ 165
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
22-325 |
8.13e-10 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 58.56 E-value: 8.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWhNFGDEGSLKNQraiLRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKPyRDEMVISSKagyf 101
Cdd:cd19157 7 GVKMPWLGLGVF-KVEEGSEVVNA---VKTALKNGYRSIDTAAIYG-----NEEGVGKGIKESGIP-REELFITSK---- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 102 MWDGPYGewgsrkY--LISSLDQSLKRMGLDYVDIFYSHRPDPNTpIEETMGALASVVQQGKALYVGISSYTPE--QTLA 177
Cdd:cd19157 73 VWNADQG------YdsTLKAFEASLERLGLDYLDLYLIHWPVKGK-YKETWKALEKLYKDGRVRAIGVSNFQVHhlEDLL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 178 AKKELdrlgVPlLIHQ----PRYSmfdrtieRSGLLYTLDEIGAGCIVFSPLSQGMLTDrylkgipkdsraalgvhlgee 253
Cdd:cd19157 146 ADAEI----VP-MVNQvefhPRLT-------QKELRDYCKKQGIQLEAWSPLMQGQLLD--------------------- 192
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2676402920 254 riNEVylervrgLSAIAEARGQTLAQMALLWTLRNPGVTsalIGASSVKQ-LEDNIAAIhgpDFE--PEELEAID 325
Cdd:cd19157 193 --NPV-------LKEIAEKYNKSVAQVILRWDLQNGVVT---IPKSIKEHrIIENADVF---DFElsQEDMDKID 252
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
22-338 |
4.27e-09 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 56.65 E-value: 4.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWHNfgDEGslKNQRAIlRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKP---YRDEMVISSKa 98
Cdd:cd19123 9 GDLIPALGLGTWKS--KPG--EVGQAV-KQALEAGYRHIDCAAIYG-----NEAEIGAALAEVFKEgkvKREDLWITSK- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 99 gyfMWDGPYgewgSRKYLISSLDQSLKRMGLDYVDIFYSHRP------------------DPNTPIEETMGALASVVQQG 160
Cdd:cd19123 78 ---LWNNSH----APEDVLPALEKTLADLQLDYLDLYLMHWPvalkkgvgfpesgedllsLSPIPLEDTWRAMEELVDKG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 161 KALYVGISSYTPE--QTLAAKKEldrlgVPLLIHQPRYSMFdrtIERSGLLYTLDEIGAGCIVFSPLSQGmltDRylkgi 238
Cdd:cd19123 151 LCRHIGVSNFSVKklEDLLATAR-----IKPAVNQVELHPY---LQQPELLAFCRDNGIHLTAYSPLGSG---DR----- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 239 PKDSRAALGVHLGEERInevylervrgLSAIAEARGQTLAQMALLWTL-RNpgvTSALIGASSVKQLEDNIAAIHgpdfe 317
Cdd:cd19123 215 PAAMKAEGEPVLLEDPV----------INKIAEKHGASPAQVLIAWAIqRG---TVVIPKSVNPERIQQNLEAAE----- 276
|
330 340
....*....|....*....|.
gi 2676402920 318 pEELEAIDVFAVHGTDSGsHR 338
Cdd:cd19123 277 -VELDASDMATIAALDRH-HR 295
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
21-173 |
5.35e-09 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 56.27 E-value: 5.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLGLWHNFGDEgslknQRAILRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKPY----RDEMVISS 96
Cdd:cd19118 3 TGNKIPAIGLGTWQAEPGE-----VGAAVKIALKAGYRHLDLAKVYQ-----NQHEVGQALKELLKEEpgvkREDLFITS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 97 KAgyfmwdgpygeWGSR---KYLISSLDQSLKRMGLDYVDIFYSHRP---------DPNTP---------------IEET 149
Cdd:cd19118 73 KL-----------WNNShrpEYVEPALDDTLKELGLDYLDLYLIHWPvafkptgdlNPLTAvptnggevdldlsvsLVDT 141
|
170 180
....*....|....*....|....
gi 2676402920 150 MGALASVVQQGKALYVGISSYTPE 173
Cdd:cd19118 142 WKAMVELKKTGKVKSIGVSNFSID 165
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
21-174 |
7.33e-09 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 56.24 E-value: 7.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLGLWHNfgDEGSLKNQraiLRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKPY----RDEMVISS 96
Cdd:cd19106 3 TGQKMPLIGLGTWKS--KPGQVKAA---VKYALDAGYRHIDCAAVYG-----NEQEVGEALKEKVGPGkavpREDLFVTS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 97 KagyfMWDGPYGEWGSRkyliSSLDQSLKRMGLDYVDIFYSHRP------------DPN-------TPIEETMGALASVV 157
Cdd:cd19106 73 K----LWNTKHHPEDVE----PALRKTLKDLQLDYLDLYLIHWPyafergdnpfpkNPDgtirydsTHYKETWKAMEKLV 144
|
170
....*....|....*..
gi 2676402920 158 QQGKALYVGISSYTPEQ 174
Cdd:cd19106 145 DKGLVKAIGLSNFNSRQ 161
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
25-336 |
1.10e-08 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 55.25 E-value: 1.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 25 LPEISLGLWHNFGDEGSlknqRAILRrAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKPyRDEMVISSKagyfMWD 104
Cdd:cd19134 11 MPVIGLGVGELSDDEAE----RSVSA-ALEAGYRLIDTAAAYG-----NEAAVGRAIAASGIP-RGELFVTTK----LAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 105 GPYGEWGSRKYLISSLDqslkRMGLDYVDIFYSHRPDPNT-PIEETMGALASVVQQGKALYVGISSYTPEQTlaaKKELD 183
Cdd:cd19134 76 PDQGFTASQAACRASLE----RLGLDYVDLYLIHWPAGREgKYVDSWGGLMKLREEGLARSIGVSNFTAEHL---ENLID 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 184 RLGVPLLIHQprysmfdrtIERSGLLY--TLDEIGAGCIV----FSPLSQGMLTDRylkgipkdsraalgvhlgeeriNE 257
Cdd:cd19134 149 LTFFTPAVNQ---------IELHPLLNqaELRKVNAQHGIvtqaYSPLGVGRLLDN----------------------PA 197
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2676402920 258 VylervrglSAIAEARGQTLAQMALLWTLRNpGVTsALIGASSVKQLEDNIAAIhgpDFepeELEAIDVFAVHGTDSGS 336
Cdd:cd19134 198 V--------TAIAAAHGRTPAQVLLRWSLQL-GNV-VISRSSNPERIASNLDVF---DF---ELTADHMDALDGLDDGT 260
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
22-325 |
1.24e-08 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 55.11 E-value: 1.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWHNFGDEGSlknqrAILRRAFDMGVTHFDLANNYGIPAGSAEShfgdVLASDFKpyRDEMVISSKagyf 101
Cdd:cd19127 6 GVEMPALGLGVFQTPPEETA-----DAVATALADGYRLIDTAAAYGNEREVGEG----IRRSGVD--RSDIFVTTK---- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 102 MWDGPYGEWGSRKylisSLDQSLKRMGLDYVDIFYSHRPDPNTpIEETMG---ALASVVQQGKALYVGISSYTPEQTlaa 178
Cdd:cd19127 71 LWISDYGYDKALR----GFDASLRRLGLDYVDLYLLHWPVPND-FDRTIQaykALEKLLAEGRVRAIGVSNFTPEHL--- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 179 KKELDRLGVPLLIHQ----PRYSMFDrtiersgLLYTLDEIGAGCIVFSPLSqGMLTDRylkgiPKDSRAALGVhLGEER 254
Cdd:cd19127 143 ERLIDATTVVPAVNQvelhPYFSQKD-------LRAFHRRLGIVTQAWSPIG-GVMRYG-----ASGPTGPGDV-LQDPT 208
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2676402920 255 InevylervrglSAIAEARGQTLAQMALLWTLRNpGVtSALIGASSVKQLEDNIAAIhgpDFE--PEELEAID 325
Cdd:cd19127 209 I-----------TGLAEKYGKTPAQIVLRWHLQN-GV-SAIPKSVHPERIAENIDIF---DFAlsAEDMAAID 265
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
22-325 |
1.46e-08 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 54.75 E-value: 1.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWH-NFGDEGslknqRAILRRAFDMGVTHFDLANNYgipagSAESHFGDVLASDFKPyRDEMVISSKagy 100
Cdd:cd19126 6 GTRMPWLGLGVFQtPDGDET-----ERAVQTALENGYRSIDTAAIY-----KNEEGVGEAIRESGVP-REELFVTTK--- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 101 fMWDGpygEWGSRKYLiSSLDQSLKRMGLDYVDIFYSHRPDPNTpIEETMGALASVVQQGKALYVGISSYTP---EQTLA 177
Cdd:cd19126 72 -LWND---DQRARRTE-DAFQESLDRLGLDYVDLYLIHWPGKDK-FIDTWKALEKLYASGKVKAIGVSNFQEhhlEELLA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 178 AKKeldrlgVPLLIHQPRYSMFdrtIERSGLLYTLDEIGAGCIVFSPLSQGmltdrylkgipkdsraalgvHLGEERIne 257
Cdd:cd19126 146 HAD------VVPAVNQVEFHPY---LTQKELRGYCKSKGIVVEAWSPLGQG--------------------GLLSNPV-- 194
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2676402920 258 vylervrgLSAIAEARGQTLAQMALLWTLRNPGVT-SALIGASSVKQLEDNIaaihgpDFE--PEELEAID 325
Cdd:cd19126 195 --------LAAIGEKYGKSAAQVVLRWDIQHGVVTiPKSVHASRIKENADIF------DFElsEDDMTAID 251
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
20-193 |
1.70e-08 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 55.04 E-value: 1.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 20 KSGLKLPEISLGLWHnfGDEGSLKNQraiLRRAFDMGVTHFDLANNYGIpagsaESHFGDVLASDFKP---YRDEMVISS 96
Cdd:cd19125 6 NTGAKIPAVGLGTWQ--ADPGVVGNA---VKTAIKEGYRHIDCAAIYGN-----EKEIGKALKKLFEDgvvKREDLFITS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 97 KagyfMW-------DGPygewgsrkyliSSLDQSLKRMGLDYVDIFYSHRP--------------DPNTPIEETMGALAS 155
Cdd:cd19125 76 K----LWctdhapeDVP-----------PALEKTLKDLQLDYLDLYLIHWPvrlkkgahmpepeeVLPPDIPSTWKAMEK 140
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2676402920 156 VVQQGKALYVGISSYTpeqtlaaKKELDRL----GVPLLIHQ 193
Cdd:cd19125 141 LVDSGKVRAIGVSNFS-------VKKLEDLlavaRVPPAVNQ 175
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
22-325 |
7.88e-08 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 52.91 E-value: 7.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWH-NFGDEGSlknqrAILRRAFDMGVTHFDLANNYgipagSAESHFGDVLASDFKPyRDEMVISSKagy 100
Cdd:cd19156 6 GVEMPRLGLGVWRvQDGAEAE-----NAVKWAIEAGYRHIDTAAIY-----KNEEGVGQGIRESGVP-REEVFVTTK--- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 101 fMWDGPYGewgsRKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTPIeETMGALASVVQQGKALYVGISSYTP---EQTLA 177
Cdd:cd19156 72 -LWNSDQG----YESTLAAFEESLEKLGLDYVDLYLIHWPVKGKFK-DTWKAFEKLYKEKKVRAIGVSNFHEhhlEELLK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 178 AKK--------ELDrlgvPLLIHQPrysmfdrtiersgLLYTLDEIGAGCIVFSPLSQGmltdrylkgipkdsraalgvH 249
Cdd:cd19156 146 SCKvapmvnqiELH----PLLTQEP-------------LRKFCKEKNIAVEAWSPLGQG--------------------K 188
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2676402920 250 LGEERInevylervrgLSAIAEARGQTLAQMALLWTLRNPGVTsaLIGASSVKQLEDNIAAIhgpDFE--PEELEAID 325
Cdd:cd19156 189 LLSNPV----------LKAIGKKYGKSAAQVIIRWDIQHGIIT--IPKSVHEERIQENFDVF---DFEltAEEIRQID 251
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
21-145 |
1.36e-07 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 52.12 E-value: 1.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLGLWHNFGDEGSLKNQRAIlrRAfdmGVTHFDLANNYGipagsAESHFGDVLASDFKPyRDEMVISSKagy 100
Cdd:cd19117 10 TGAEIPAVGLGTWQSKPNEVAKAVEAAL--KA---GYRHIDTAAIYG-----NEEEVGQGIKDSGVP-REEIFITTK--- 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2676402920 101 fMWdgpyGEWGSRkyLISSLDQSLKRMGLDYVDIFYSHRPDPNTP 145
Cdd:cd19117 76 -LW----CTWHRR--VEEALDQSLKKLGLDYVDLYLMHWPVPLDP 113
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
21-171 |
1.40e-07 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 52.45 E-value: 1.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLGLWHNfgDEGSLKNQraiLRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKP---YRDEMVISSK 97
Cdd:cd19113 7 SGYKMPSVGFGCWKL--DNATAADQ---IYQAIKAGYRLFDGAEDYG-----NEKEVGEGVNRAIDEglvKREELFLTSK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 98 agyfMWDgpygEWGSRKYLISSLDQSLKRMGLDYVDIFYSHRP-------------------------DPNTPIEETMGA 152
Cdd:cd19113 77 ----LWN----NFHDPKNVETALNKTLSDLKLDYVDLFLIHFPiafkfvpieekyppgfycgdgdnfvYEDVPILDTWKA 148
|
170
....*....|....*....
gi 2676402920 153 LASVVQQGKALYVGISSYT 171
Cdd:cd19113 149 LEKLVDAGKIKSIGVSNFP 167
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
21-325 |
1.54e-07 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 51.89 E-value: 1.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLGLWHNFGDEGSLKnqRAILRrAFDMGVTHFDLANNYGIpagsaESHFGDVLASDFK----PYRDEMVISS 96
Cdd:cd19124 1 SGQTMPVIGMGTASDPPSPEDIK--AAVLE-AIEVGYRHFDTAAAYGT-----EEALGEALAEALRlglvKSRDELFVTS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 97 KAgyfmwdgpygeWGS---RKYLISSLDQSLKRMGLDYVDIFYSHRPDPNTP----------------IEETMGALASVV 157
Cdd:cd19124 73 KL-----------WCSdahPDLVLPALKKSLRNLQLEYVDLYLIHWPVSLKPgkfsfpieeedflpfdIKGVWEAMEECQ 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 158 QQGKALYVGISSYTpeqtlaAKKeLDRL----GVPLLIHQprysmfdrtIERSGL--LYTLDEI--GAGCIV--FSPLsq 227
Cdd:cd19124 142 RLGLTKAIGVSNFS------CKK-LQELlsfaTIPPAVNQ---------VEMNPAwqQKKLREFckANGIHVtaYSPL-- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 228 gmltdrylkgipkdsrAALGVHLGEERI--NEVylervrgLSAIAEARGQTLAQMALLWTLRnpgvtsalIGASSV---- 301
Cdd:cd19124 204 ----------------GAPGTKWGSNAVmeSDV-------LKEIAAAKGKTVAQVSLRWVYE--------QGVSLVvksf 252
|
330 340
....*....|....*....|....*...
gi 2676402920 302 --KQLEDNIAAIhgpDFE--PEELEAID 325
Cdd:cd19124 253 nkERMKQNLDIF---DWEltEEDLEKIS 277
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
21-171 |
1.17e-06 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 49.45 E-value: 1.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLGLWHnfGDEGSLKnqrAILRRAFDMGVTHFDLANNYG----IPAGSAESHFGDVlasdfkpYRDEMVISS 96
Cdd:cd19121 8 TGASIPAVGLGTWQ--AKAGEVK---AAVAHALKIGYRHIDGALCYQnedeVGEGIKEAIAGGV-------KREDLFVTT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 97 KAgyfmwdgpygeWGS-RKYLISSLDQSLKRMGLDYVDIFYSHRP--------DPNTPIEE--------------TMGAL 153
Cdd:cd19121 76 KL-----------WSTyHRRVELCLDRSLKSLGLDYVDLYLVHWPvllnpngnHDLFPTLPdgsrdldwdwnhvdTWKQM 144
|
170
....*....|....*...
gi 2676402920 154 ASVVQQGKALYVGISSYT 171
Cdd:cd19121 145 EKVLKTGKTKAIGVSNYS 162
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
22-174 |
1.38e-06 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 48.72 E-value: 1.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWHNFGDEGSlknQRAILRrAFDMGVTHFDLANNYGIPA--GSAeshfgdVLASDFKpyRDEMVISSKag 99
Cdd:cd19133 6 GVEMPILGFGVFQIPDPEEC---ERAVLE-AIKAGYRLIDTAAAYGNEEavGRA------IKKSGIP--REELFITTK-- 71
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2676402920 100 yfMWDGPYGEWGSRKylisSLDQSLKRMGLDYVDIFYSHRPDPNtpIEETMGALASVVQQGKALYVGISSYTPEQ 174
Cdd:cd19133 72 --LWIQDAGYEKAKK----AFERSLKRLGLDYLDLYLIHQPFGD--VYGAWRAMEELYKEGKIRAIGVSNFYPDR 138
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
26-171 |
4.12e-06 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 47.52 E-value: 4.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 26 PEISLGLWHNFGDEgslkNQRAIlRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKPY---RDEMVISSKagyfM 102
Cdd:cd19128 2 PRLGFGTYKITESE----SKEAV-KNAIKAGYRHIDCAYYYG-----NEAFIGIAFSEIFKDGgvkREDLFITSK----L 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 103 WdgPYGEwgsRKYLIS-SLDQSLKRMGLDYVDIFYSHRP---DPNT----------------PIEETMGALASVVQQGKA 162
Cdd:cd19128 68 W--PTMH---QPENVKeQLLITLQDLQLEYLDLFLIHWPlafDMDTdgdprddnqiqslskkPLEDTWRAMEQCVDEKLT 142
|
....*....
gi 2676402920 163 LYVGISSYT 171
Cdd:cd19128 143 KNIGVSNYS 151
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
21-324 |
4.65e-06 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 47.80 E-value: 4.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLGLWHNfgDEGSLKNQraiLRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKP---YRDEMVISSK 97
Cdd:cd19115 9 SGYDMPLVGFGLWKV--NNDTCADQ---VYNAIKAGYRLFDGACDYG-----NEVEAGQGVARAIKEgivKREDLFIVSK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 98 agyfMW----DGPYGEWGSRKylissldqSLKRMGLDYVDIFYSHRP------DP------------------NTPIEET 149
Cdd:cd19115 79 ----LWntfhDGERVEPICRK--------QLADWGIDYFDLFLIHFPialkyvDPavryppgwfydgkkvefsNAPIQET 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 150 MGALASVVQQGKALYVGISSYTPEQTLAAKKELDRLGVPLLI-HQPrYSMFDRTIErsgllYTLDEigaGCIV-----FS 223
Cdd:cd19115 147 WTAMEKLVDKGLARSIGVSNFSAQLLMDLLRYARIRPATLQIeHHP-YLTQPRLVK-----YAQKE---GIAVtayssFG 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 224 PLSQGMLTDRYLKGIPKdsraalgvhLGEERInevylervrgLSAIAEARGQTLAQMALLW-TLRNpgvtSALIGASS-V 301
Cdd:cd19115 218 PQSFLELDLPGAKDTPP---------LFEHDV----------IKSIAEKHGKTPAQVLLRWaTQRG----IAVIPKSNnP 274
|
330 340
....*....|....*....|...
gi 2676402920 302 KQLEDNIAAIhGPDFEPEELEAI 324
Cdd:cd19115 275 KRLAQNLDVT-GFDLEAEEIKAI 296
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
25-172 |
7.67e-06 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 46.86 E-value: 7.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 25 LPEISLGLWHNFGDEgslkNQRAILRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKPY---RDEMVISSKAGyf 101
Cdd:cd19136 1 MPILGLGTFRLRGEE----EVRQAVDAALKAGYRLIDTASVYR-----NEADIGKALRDLLPKYglsREDIFITSKLA-- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 102 mwdgPYGEWGSRKYliSSLDQSLKRMGLDYVDIFYSHRP-----DPNTPIE-----ETMGALASVVQQGKALYVGISSYT 171
Cdd:cd19136 70 ----PKDQGYEKAR--AACLGSLERLGTDYLDLYLIHWPgvqglKPSDPRNaelrrESWRALEDLYKEGKLRAIGVSNYT 143
|
.
gi 2676402920 172 P 172
Cdd:cd19136 144 V 144
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
22-176 |
1.55e-05 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 46.01 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWHNFGDEGslknqRAILRRAFDMGVTHFDLANNYGIPAGSAESHFGDVLASDFKpyRDEMVISSKagyf 101
Cdd:cd19114 1 GDKMPLVGFGTAKIKANET-----EEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVK--REDLFIVTK---- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 102 MWDGPYGewgsRKYLISSLDQSLKRMGLDYVDIFYSHRP------DP-------------------NTPIEETMGALASV 156
Cdd:cd19114 70 LWNNFHG----KDHVREAFDRQLKDYGLDYIDLYLIHFPipaayvDPaenypflwkdkelkkfpleQSPMQECWREMEKL 145
|
170 180
....*....|....*....|
gi 2676402920 157 VQQGKALYVGISSYTPEQTL 176
Cdd:cd19114 146 VDAGLVRNIGIANFNVQLIL 165
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
22-193 |
2.48e-05 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 45.06 E-value: 2.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWhnfgdEGSLKNQRAILRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDFKPyRDEMVISSKagyf 101
Cdd:PRK11565 12 GNVMPQLGLGVW-----QASNEEVITAIHKALEVGYRSIDTAAIYK-----NEEGVGKALKEASVA-REELFITTK---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 102 MWDGpygewgSRKYLISSLDQSLKRMGLDYVDIFYSHRPDPntPIEETMGA---LASVVQQGKALYVGISSYTPEQTlaa 178
Cdd:PRK11565 77 LWND------DHKRPREALEESLKKLQLDYVDLYLMHWPVP--AIDHYVEAwkgMIELQKEGLIKSIGVCNFQIHHL--- 145
|
170
....*....|....*
gi 2676402920 179 KKELDRLGVPLLIHQ 193
Cdd:PRK11565 146 QRLIDETGVTPVINQ 160
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
21-140 |
4.20e-05 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 44.80 E-value: 4.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 21 SGLKLPEISLGLWHNFGDEGslkNQRAILRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDF---KPYRDEMVISSK 97
Cdd:cd19119 8 TGASIPALGLGTASPHEDRA---EVKEAVEAAIKEGYRHIDTAYAYE-----TEDFVGEAIKRAIddgSIKREELFITTK 79
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 2676402920 98 AGYFMWDgpygewgsrkYLISSLDQSLKRMGLDYVDIFYSHRP 140
Cdd:cd19119 80 VWPTFYD----------EVERSLDESLKALGLDYVDLLLVHWP 112
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
22-174 |
1.76e-04 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 42.90 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWhnfgdEGSLKNQRAILRRAFDMGVTHFDLANNYGipagsAESHFGDVLASDF---KPYRDEMVISSKA 98
Cdd:cd19155 9 GEKMPVVGLGTW-----QSSPEEIETAVDTALEAGYRHIDTAYVYR-----NEAAIGNVLKKWIdsgKVKREELFIVTKL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 99 gyfmwdgPYGewGSRKYLISS-LDQSLKRMGLDYVDIFYSHRP---------------------DPNTPIEETMGALASV 156
Cdd:cd19155 79 -------PPG--GNRREKVEKfLLKSLEKLQLDYVDLYLIHFPvgslskeddsgkldptgehkqDYTTDLLDIWKAMEAQ 149
|
170
....*....|....*...
gi 2676402920 157 VQQGKALYVGISSYTPEQ 174
Cdd:cd19155 150 VDQGLTRSIGLSNFNREQ 167
|
|
| PRK14863 |
PRK14863 |
bifunctional regulator KidO; Provisional |
46-325 |
5.99e-04 |
|
bifunctional regulator KidO; Provisional
Pssm-ID: 184865 [Multi-domain] Cd Length: 292 Bit Score: 41.06 E-value: 5.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 46 RAILRRAFDMGVTHFDLANNYGipagSAESHFGDVLASDfKPYRdeMVISSKAgyfMWDGPygewgsrKYLISSLDQSLK 125
Cdd:PRK14863 35 RDILNIAARAGLSVLDASGLFG----RAETVLGQLIPRP-VPFR--VTLSTVR---ADRGP-------DFVEAEARASLR 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 126 RMGLDYVDIFYSHRPdpnTPIEETMGA-----LASVVQQGKALYVGISSYTPEQT--LAAKKELDRLGVPLlihqprySM 198
Cdd:PRK14863 98 RMGVERADAILVHSP---TELFGPHGAalwerLQALKDQGLFAKIGVSAHASDDPvgVARRFKPDILQAPA-------SL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 199 FDRTIERSGLLYTLDEIGAGCIVFSPLSQGMLTdrylkgIPKDSRAAlgvHLGEErinEVYLERVRGLsaIAEARGQTLa 278
Cdd:PRK14863 168 LDQRLLADGSLQRIAGMGVEVHLRSIFLNGLLF------LPPDRVPA---QLKGA---SGRLSRVRRM--IAEGRSDPL- 232
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2676402920 279 QMALLWTLRNPGVTSALIGASSVKQLEDNIAAIHG--PDFEPEELeAID 325
Cdd:PRK14863 233 QAALGFALSRPEGSAVLVGVNSAAELSAVVAAASSppPDLDWDDM-AID 280
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
46-174 |
1.45e-03 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 39.75 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 46 RAILRRAFDMGVTHFDLANNYgipagSAESHFGDVLASDFKP---YRDEMVISSKagyfMWDGPYgewgSRKYLISSLDQ 122
Cdd:cd19129 22 RNAVKAALEAGFRHFDCAERY-----RNEAEVGEAMQEVFKAgkiRREDLFVTTK----LWNTNH----RPERVKPAFEA 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2676402920 123 SLKRMGLDYVDIFYSHRP--------------------DPNTPIEETMGALASVVQQGKALYVGISSYTPEQ 174
Cdd:cd19129 89 SLKRLQLDYLDLYLIHTPfafqpgdeqdprdangnviyDDGVTLLDTWRAMERLVDEGRCKAIGLSDVSLEK 160
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
52-164 |
1.49e-03 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 39.91 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 52 AFDMGVTHFDLANNYGIpagsaESHFGDVLAS---DFKPYRDEMVISSKAgyfmwdgpygeWGS--RKYLI-SSLDQSLK 125
Cdd:cd19108 36 AIDAGFRHIDSAYLYQN-----EEEVGQAIRSkiaDGTVKREDIFYTSKL-----------WCTfhRPELVrPALEKSLK 99
|
90 100 110
....*....|....*....|....*....|....*....
gi 2676402920 126 RMGLDYVDIFYSHRPDPNTPIEEtmgaLASVVQQGKALY 164
Cdd:cd19108 100 KLQLDYVDLYLIHFPVALKPGEE----LFPKDENGKLIF 134
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
22-174 |
5.46e-03 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 38.17 E-value: 5.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 22 GLKLPEISLGLWHnfgdegSLKNQ-RAILRRAFDMGVTHFDLANNYgipagSAESHFGDVLASDFKP---YRDEMVISSK 97
Cdd:cd19107 1 GAKMPILGLGTWK------SPPGQvTEAVKVAIDAGYRHIDCAYVY-----QNENEVGEAIQEKIKEqvvKREDLFIVSK 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2676402920 98 agyfMWDGPYgewgSRKYLISSLDQSLKRMGLDYVDIFYSHRPD-------------------PNTPIEETMGALASVVQ 158
Cdd:cd19107 70 ----LWCTFH----EKGLVKGACQKTLSDLKLDYLDLYLIHWPTgfkpgkelfpldesgnvipSDTTFLDTWEAMEELVD 141
|
170
....*....|....*.
gi 2676402920 159 QGKALYVGISSYTPEQ 174
Cdd:cd19107 142 EGLVKAIGVSNFNHLQ 157
|
|
| |
