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Conserved domains on  [gi|2677057269|ref|WP_332909004|]
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WYL domain-containing protein [Paracoccus binzhouensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YobV super family cl28501
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 22-187 2.91e-08

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


The actual alignment was detected with superfamily member COG2378:

Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 53.93  E-value: 2.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2677057269  22 INRADIVDFFGVSVPQASKDL-TLyqeRAPGNMVYDTRGK--RYVAAERFVLRFLDPDPY----VYLAqLRSVAEGTVPA 94
Cdd:COG2378    20 VTAAELAERLEVSERTIYRDIdAL---RELGVPIEAERGRggGYRLRDGYRLPPLMLTEEealaLLLA-LRLLAALGGAP 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2677057269  95 HDS--------LIAVLPNTD----------VALTPKRDIDIEVLRNVLDATREGASLDIYYQSmnrSRPDPIWRRITPHA 156
Cdd:COG2378    96 LAEaaasalakLEAVLPERLrerlealaerVGVDPPPEVDPEVLETLREAIRERRRLRIDYRS---GRGEPTERTVEPYG 172

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2677057269 157 FGYDGFRWHARAYCHLEHKFKDFLLPRILDV 187
Cdd:COG2378   173 LVFYGGRWYLVAWCELRDDIRTFRLDRIRSL 203
WYL super family cl14852
WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the ...
 118-260 4.87e-07

WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.


The actual alignment was detected with superfamily member pfam13280:

Pssm-ID: 449366  Cd Length: 172  Bit Score: 48.80  E-value: 4.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2677057269 118 EVLRNVLDATREGASLDIYYQSMNRsrpDPIWRRITPHAFGYDGFRWHARAYCHLEHKFKDFLLPRILDVGRKDKPGASG 197
Cdd:pfam13280   1 EVLETLREAILERRRVRFRYRSPRG---EGTERTVEPYGLVYKDGRWYLVAYCRLRDDIRTFRLDRIESVEVLDEPFEPP 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2677057269 198 DEDW--LWNNFFDVVIGPHP---DLTESQKKVVAKDYGF------EHGNG--TLSVRYAMLFYVLKRLGLLGDAAK 260
Cdd:pfam13280  78 DFDLaeYLRRSFGVFPGPIEvklRFSPEAARRLRERRFPdqqieeEDDDGslRVTLPVDDLEELARWLLSFGPDVE 153
 
Name Accession Description Interval E-value
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 22-187 2.91e-08

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 53.93  E-value: 2.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2677057269  22 INRADIVDFFGVSVPQASKDL-TLyqeRAPGNMVYDTRGK--RYVAAERFVLRFLDPDPY----VYLAqLRSVAEGTVPA 94
Cdd:COG2378    20 VTAAELAERLEVSERTIYRDIdAL---RELGVPIEAERGRggGYRLRDGYRLPPLMLTEEealaLLLA-LRLLAALGGAP 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2677057269  95 HDS--------LIAVLPNTD----------VALTPKRDIDIEVLRNVLDATREGASLDIYYQSmnrSRPDPIWRRITPHA 156
Cdd:COG2378    96 LAEaaasalakLEAVLPERLrerlealaerVGVDPPPEVDPEVLETLREAIRERRRLRIDYRS---GRGEPTERTVEPYG 172

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2677057269 157 FGYDGFRWHARAYCHLEHKFKDFLLPRILDV 187
Cdd:COG2378   173 LVFYGGRWYLVAWCELRDDIRTFRLDRIRSL 203
WYL pfam13280
WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the ...
 118-260 4.87e-07

WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.


Pssm-ID: 433082  Cd Length: 172  Bit Score: 48.80  E-value: 4.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2677057269 118 EVLRNVLDATREGASLDIYYQSMNRsrpDPIWRRITPHAFGYDGFRWHARAYCHLEHKFKDFLLPRILDVGRKDKPGASG 197
Cdd:pfam13280   1 EVLETLREAILERRRVRFRYRSPRG---EGTERTVEPYGLVYKDGRWYLVAYCRLRDDIRTFRLDRIESVEVLDEPFEPP 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2677057269 198 DEDW--LWNNFFDVVIGPHP---DLTESQKKVVAKDYGF------EHGNG--TLSVRYAMLFYVLKRLGLLGDAAK 260
Cdd:pfam13280  78 DFDLaeYLRRSFGVFPGPIEvklRFSPEAARRLRERRFPdqqieeEDDDGslRVTLPVDDLEELARWLLSFGPDVE 153
 
Name Accession Description Interval E-value
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 22-187 2.91e-08

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 53.93  E-value: 2.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2677057269  22 INRADIVDFFGVSVPQASKDL-TLyqeRAPGNMVYDTRGK--RYVAAERFVLRFLDPDPY----VYLAqLRSVAEGTVPA 94
Cdd:COG2378    20 VTAAELAERLEVSERTIYRDIdAL---RELGVPIEAERGRggGYRLRDGYRLPPLMLTEEealaLLLA-LRLLAALGGAP 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2677057269  95 HDS--------LIAVLPNTD----------VALTPKRDIDIEVLRNVLDATREGASLDIYYQSmnrSRPDPIWRRITPHA 156
Cdd:COG2378    96 LAEaaasalakLEAVLPERLrerlealaerVGVDPPPEVDPEVLETLREAIRERRRLRIDYRS---GRGEPTERTVEPYG 172

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2677057269 157 FGYDGFRWHARAYCHLEHKFKDFLLPRILDV 187
Cdd:COG2378   173 LVFYGGRWYLVAWCELRDDIRTFRLDRIRSL 203
WYL pfam13280
WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the ...
 118-260 4.87e-07

WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.


Pssm-ID: 433082  Cd Length: 172  Bit Score: 48.80  E-value: 4.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2677057269 118 EVLRNVLDATREGASLDIYYQSMNRsrpDPIWRRITPHAFGYDGFRWHARAYCHLEHKFKDFLLPRILDVGRKDKPGASG 197
Cdd:pfam13280   1 EVLETLREAILERRRVRFRYRSPRG---EGTERTVEPYGLVYKDGRWYLVAYCRLRDDIRTFRLDRIESVEVLDEPFEPP 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2677057269 198 DEDW--LWNNFFDVVIGPHP---DLTESQKKVVAKDYGF------EHGNG--TLSVRYAMLFYVLKRLGLLGDAAK 260
Cdd:pfam13280  78 DFDLaeYLRRSFGVFPGPIEvklRFSPEAARRLRERRFPdqqieeEDDDGslRVTLPVDDLEELARWLLSFGPDVE 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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