NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2679308896|ref|WP_333563120|]
View 

UvrD-helicase domain-containing protein [Aeromonas sp. QDB36]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG3972 super family cl28313
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
14-58 7.98e-11

Superfamily I DNA and RNA helicases [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG3972:

Pssm-ID: 443172 [Multi-domain]  Cd Length: 565  Bit Score: 55.61  E-value: 7.98e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2679308896  14 RYQTILVDEVQDFESEWVKILRDNFLSSEGEMVLFGDESQNIYER 58
Cdd:COG3972   288 IYDAILIDEAQDFEPEFLRLLYQLLKPPKKRLIWAYDEAQNIYGR 332
 
Name Accession Description Interval E-value
COG3972 COG3972
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
14-58 7.98e-11

Superfamily I DNA and RNA helicases [Replication, recombination and repair];


Pssm-ID: 443172 [Multi-domain]  Cd Length: 565  Bit Score: 55.61  E-value: 7.98e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2679308896  14 RYQTILVDEVQDFESEWVKILRDNFLSSEGEMVLFGDESQNIYER 58
Cdd:COG3972   288 IYDAILIDEAQDFEPEFLRLLYQLLKPPKKRLIWAYDEAQNIYGR 332
DEXQc_UvrD cd17932
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ...
 14-56 1.09e-03

DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350690 [Multi-domain]  Cd Length: 189  Bit Score: 35.18  E-value: 1.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2679308896  14 RYQTILVDEVQDF---ESEWVKILrdnfLSSEGEMVLFGDESQNIY 56
Cdd:cd17932   119 RFRYILVDEYQDTnplQYELLKLL----AGDGKNLFVVGDDDQSIY 160
UvrD-helicase pfam00580
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ...
 14-56 2.10e-03

UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.


Pssm-ID: 395462 [Multi-domain]  Cd Length: 267  Bit Score: 34.53  E-value: 2.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2679308896  14 RYQTILVDEVQDFES---EWVKILrdnfLSSEGEMVLFGDESQNIY 56
Cdd:pfam00580 208 RFKYILVDEFQDTNPiqyRLLKLL----AGGHENLFLVGDPDQSIY 249
 
Name Accession Description Interval E-value
COG3972 COG3972
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
14-58 7.98e-11

Superfamily I DNA and RNA helicases [Replication, recombination and repair];


Pssm-ID: 443172 [Multi-domain]  Cd Length: 565  Bit Score: 55.61  E-value: 7.98e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2679308896  14 RYQTILVDEVQDFESEWVKILRDNFLSSEGEMVLFGDESQNIYER 58
Cdd:COG3972   288 IYDAILIDEAQDFEPEFLRLLYQLLKPPKKRLIWAYDEAQNIYGR 332
DEXQc_UvrD cd17932
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ...
 14-56 1.09e-03

DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350690 [Multi-domain]  Cd Length: 189  Bit Score: 35.18  E-value: 1.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2679308896  14 RYQTILVDEVQDF---ESEWVKILrdnfLSSEGEMVLFGDESQNIY 56
Cdd:cd17932   119 RFRYILVDEYQDTnplQYELLKLL----AGDGKNLFVVGDDDQSIY 160
UvrD-helicase pfam00580
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ...
 14-56 2.10e-03

UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.


Pssm-ID: 395462 [Multi-domain]  Cd Length: 267  Bit Score: 34.53  E-value: 2.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2679308896  14 RYQTILVDEVQDFES---EWVKILrdnfLSSEGEMVLFGDESQNIY 56
Cdd:pfam00580 208 RFKYILVDEFQDTNPiqyRLLKLL----AGGHENLFLVGDPDQSIY 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH