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Conserved domains on  [gi|2686881984|ref|WP_333792748|]
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SMR family transporter, partial [Megamonas funiformis]

Protein Classification

DMT family transporter( domain architecture ID 10005269)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Gene Ontology:  GO:0055085|GO:0022857|GO:0016020
PubMed:  11432728
TCDB:  2.A.7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
4-75 4.40e-11

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


:

Pssm-ID: 441679  Cd Length: 105  Bit Score: 53.56  E-value: 4.40e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2686881984   4 GWLKIIGATLFELVWVTGLKYAEL---PWQWGVTALSILGSSYCLITAGNTLPVGTAYSVFVGLSAIGTILVEFL 75
Cdd:COG2076     1 AWLYLLLAGLLEVVWTLALKLSDGftrLLPSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGIL 75
 
Name Accession Description Interval E-value
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
4-75 4.40e-11

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 53.56  E-value: 4.40e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2686881984   4 GWLKIIGATLFELVWVTGLKYAEL---PWQWGVTALSILGSSYCLITAGNTLPVGTAYSVFVGLSAIGTILVEFL 75
Cdd:COG2076     1 AWLYLLLAGLLEVVWTLALKLSDGftrLLPSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGIL 75
Multi_Drug_Res pfam00893
Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. ...
 3-75 3.45e-06

Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide and quaternary ammonium compounds, through coupling with proton influx.


Pssm-ID: 459985  Cd Length: 93  Bit Score: 40.73  E-value: 3.45e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2686881984  3 IGWLKIIGATLFELVWVTGLKYAELPWQWGVTALSILG---SSYCLITAGNTLPVGTAYSVFVGLSAIGTILVEFL 75
Cdd:pfam00893  1 MGWILLVLAIVLEVVGTSLLKYSEGFTRLWPSILVIVGyglSFYLLSLALKSIPLGVAYAVWSGIGTVGTTLVGIL 76
PRK11431 PRK11431
quaternary ammonium compound efflux SMR transporter SugE;
3-69 1.30e-03

quaternary ammonium compound efflux SMR transporter SugE;


Pssm-ID: 171110  Cd Length: 105  Bit Score: 34.45  E-value: 1.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2686881984   3 IGWLKIIGATLFELVWVTGLKYAELPWQWG---VTALSILGSSYCLITAGNTLPVGTAYSVFVGLSAIGT 69
Cdd:PRK11431    1 MSWIILVIAGLLEVVWAVGLKYTHGFSRLTpsiITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGA 70
 
Name Accession Description Interval E-value
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
4-75 4.40e-11

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 53.56  E-value: 4.40e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2686881984   4 GWLKIIGATLFELVWVTGLKYAEL---PWQWGVTALSILGSSYCLITAGNTLPVGTAYSVFVGLSAIGTILVEFL 75
Cdd:COG2076     1 AWLYLLLAGLLEVVWTLALKLSDGftrLLPSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGIL 75
Multi_Drug_Res pfam00893
Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. ...
 3-75 3.45e-06

Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide and quaternary ammonium compounds, through coupling with proton influx.


Pssm-ID: 459985  Cd Length: 93  Bit Score: 40.73  E-value: 3.45e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2686881984  3 IGWLKIIGATLFELVWVTGLKYAELPWQWGVTALSILG---SSYCLITAGNTLPVGTAYSVFVGLSAIGTILVEFL 75
Cdd:pfam00893  1 MGWILLVLAIVLEVVGTSLLKYSEGFTRLWPSILVIVGyglSFYLLSLALKSIPLGVAYAVWSGIGTVGTTLVGIL 76
PRK11431 PRK11431
quaternary ammonium compound efflux SMR transporter SugE;
3-69 1.30e-03

quaternary ammonium compound efflux SMR transporter SugE;


Pssm-ID: 171110  Cd Length: 105  Bit Score: 34.45  E-value: 1.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2686881984   3 IGWLKIIGATLFELVWVTGLKYAELPWQWG---VTALSILGSSYCLITAGNTLPVGTAYSVFVGLSAIGT 69
Cdd:PRK11431    1 MSWIILVIAGLLEVVWAVGLKYTHGFSRLTpsiITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGA 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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