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Conserved domains on  [gi|2687004001|ref|WP_333905814|]
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ATP-binding protein [Delftia acidovorans]

Protein Classification

sensor histidine kinase family protein( domain architecture ID 1004179)

sensor histidine kinase family protein may be part of a two-component regulatory system and may function as a protein kinase that phosphorylates a target protein in response to various signals; similar to Haemophilus influenzae sensor protein QseC

Gene Ontology:  GO:0007165
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PRK10337 super family cl32501
sensor protein QseC; Provisional
144-477 1.24e-70

sensor protein QseC; Provisional


The actual alignment was detected with superfamily member PRK10337:

Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 231.46  E-value: 1.24e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 144 VIQVAQDMRVRRTLARDAAWQSLLPIALLAPVLALAVWWVVRSSLAPVQRVRRELATRRPQDLAPVPAEGLPDEVRPLVA 223
Cdd:PRK10337  142 RIVVGQEWEYREDMALAIVAGQLIPWLVALPIMLIILMVLLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVE 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 224 ELNALLQRVGQAFEAQQHFVADAAHELRSPLAALKLQL-VALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEA 302
Cdd:PRK10337  222 ALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTeVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDS 301
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 303 QGTVQGLQgmqgrhgaaaaapaDVDLREVVEQALADQAVAAQQHGLDMGLS--ESPQLRQsfavaGDAQSLQMLVRNLLD 380
Cdd:PRK10337  302 LDNLQDVA--------------EIPLEDLLQSAVMDIYHTAQQAGIDVRLTlnAHPVIRT-----GQPLLLSLLVRNLLD 362
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 381 NAVKYVPQGGRVDVGWRSdaqgRALVVEDSGPGIAESERELVLRRFVRGPsaasaGQQAQGSGLGLAIVQTIAERHGARL 460
Cdd:PRK10337  363 NAIRYSPQGSVVDVTLNA----RNFTVRDNGPGVTPEALARIGERFYRPP-----GQEATGSGLGLSIVRRIAKLHGMNV 433
                         330
                  ....*....|....*..
gi 2687004001 461 LLDRSPTlGGLRVQVIW 477
Cdd:PRK10337  434 SFGNAPE-GGFEAKVSW 449
 
Name Accession Description Interval E-value
PRK10337 PRK10337
sensor protein QseC; Provisional
144-477 1.24e-70

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 231.46  E-value: 1.24e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 144 VIQVAQDMRVRRTLARDAAWQSLLPIALLAPVLALAVWWVVRSSLAPVQRVRRELATRRPQDLAPVPAEGLPDEVRPLVA 223
Cdd:PRK10337  142 RIVVGQEWEYREDMALAIVAGQLIPWLVALPIMLIILMVLLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVE 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 224 ELNALLQRVGQAFEAQQHFVADAAHELRSPLAALKLQL-VALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEA 302
Cdd:PRK10337  222 ALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTeVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDS 301
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 303 QGTVQGLQgmqgrhgaaaaapaDVDLREVVEQALADQAVAAQQHGLDMGLS--ESPQLRQsfavaGDAQSLQMLVRNLLD 380
Cdd:PRK10337  302 LDNLQDVA--------------EIPLEDLLQSAVMDIYHTAQQAGIDVRLTlnAHPVIRT-----GQPLLLSLLVRNLLD 362
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 381 NAVKYVPQGGRVDVGWRSdaqgRALVVEDSGPGIAESERELVLRRFVRGPsaasaGQQAQGSGLGLAIVQTIAERHGARL 460
Cdd:PRK10337  363 NAIRYSPQGSVVDVTLNA----RNFTVRDNGPGVTPEALARIGERFYRPP-----GQEATGSGLGLSIVRRIAKLHGMNV 433
                         330
                  ....*....|....*..
gi 2687004001 461 LLDRSPTlGGLRVQVIW 477
Cdd:PRK10337  434 SFGNAPE-GGFEAKVSW 449
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
134-478 2.43e-54

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 185.11  E-value: 2.43e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 134 RVFSLQTRSQVIQVAQDMRVRRTLARDAAWQSLLPIALLAPVLALAVWWVVRSSLAPVQRVRRELATRRPQDLAPVPAEG 213
Cdd:COG0642     5 LLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 214 LPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRSPLAALKLQLVALQRAPDvAAHDEAVQRLSAGIDRATRLVEQ 293
Cdd:COG0642    85 LLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELD-EEQREYLETILRSADRLLRLIND 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 294 LLTLARQEAqgtvqglqgmqgrhGAAAAAPADVDLREVVEQALADQAVAAQQHGLDMGLSESPQLRQsfaVAGDAQSLQM 373
Cdd:COG0642   164 LLDLSRLEA--------------GKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPT---VRGDPDRLRQ 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 374 LVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGqqaqGSGLGLAIVQTIA 453
Cdd:COG0642   227 VLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG----GTGLGLAIVKRIV 302
                         330       340
                  ....*....|....*....|....*
gi 2687004001 454 ERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:COG0642   303 ELHGGTIEVESEPG-KGTTFTVTLP 326
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
364-477 3.38e-31

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 116.35  E-value: 3.38e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 364 VAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAqGRALVVEDSGPGIAESERELVLRRFVRgpsaaSAGQQAQGSG 443
Cdd:cd16940     7 VQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADD-GAVIRVEDNGPGIDEEELEALFERFYR-----SDGQNYGGSG 80
                          90       100       110
                  ....*....|....*....|....*....|....
gi 2687004001 444 LGLAIVQTIAERHGARLLLDRSPTlGGLRVQVIW 477
Cdd:cd16940    81 LGLSIVKRIVELHGGQIFLGNAQG-GGLEAWVRL 113
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
366-479 3.89e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 107.73  E-value: 3.89e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001  366 GDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGqqaQGSGLG 445
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKI---GGTGLG 77
                           90       100       110
                   ....*....|....*....|....*....|....
gi 2687004001  446 LAIVQTIAERHGARLLLDRSPTlGGLRVQVIWPP 479
Cdd:smart00387  78 LSIVKKLVELHGGEISVESEPG-GGTTFTITLPL 110
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
366-478 1.23e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 92.43  E-value: 1.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 366 GDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRaLVVEDSGPGIAESERELVLRRFVRGPSaasagQQAQGSGLG 445
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELT-LTVEDNGIGIPPEDLPRIFEPFSTADK-----RGGGGTGLG 74
                          90       100       110
                  ....*....|....*....|....*....|...
gi 2687004001 446 LAIVQTIAERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:pfam02518  75 LSIVRKLVELLGGTITVESEPG-GGTTVTLTLP 106
 
Name Accession Description Interval E-value
PRK10337 PRK10337
sensor protein QseC; Provisional
144-477 1.24e-70

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 231.46  E-value: 1.24e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 144 VIQVAQDMRVRRTLARDAAWQSLLPIALLAPVLALAVWWVVRSSLAPVQRVRRELATRRPQDLAPVPAEGLPDEVRPLVA 223
Cdd:PRK10337  142 RIVVGQEWEYREDMALAIVAGQLIPWLVALPIMLIILMVLLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVE 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 224 ELNALLQRVGQAFEAQQHFVADAAHELRSPLAALKLQL-VALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEA 302
Cdd:PRK10337  222 ALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTeVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDS 301
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 303 QGTVQGLQgmqgrhgaaaaapaDVDLREVVEQALADQAVAAQQHGLDMGLS--ESPQLRQsfavaGDAQSLQMLVRNLLD 380
Cdd:PRK10337  302 LDNLQDVA--------------EIPLEDLLQSAVMDIYHTAQQAGIDVRLTlnAHPVIRT-----GQPLLLSLLVRNLLD 362
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 381 NAVKYVPQGGRVDVGWRSdaqgRALVVEDSGPGIAESERELVLRRFVRGPsaasaGQQAQGSGLGLAIVQTIAERHGARL 460
Cdd:PRK10337  363 NAIRYSPQGSVVDVTLNA----RNFTVRDNGPGVTPEALARIGERFYRPP-----GQEATGSGLGLSIVRRIAKLHGMNV 433
                         330
                  ....*....|....*..
gi 2687004001 461 LLDRSPTlGGLRVQVIW 477
Cdd:PRK10337  434 SFGNAPE-GGFEAKVSW 449
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
134-478 2.43e-54

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 185.11  E-value: 2.43e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 134 RVFSLQTRSQVIQVAQDMRVRRTLARDAAWQSLLPIALLAPVLALAVWWVVRSSLAPVQRVRRELATRRPQDLAPVPAEG 213
Cdd:COG0642     5 LLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 214 LPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRSPLAALKLQLVALQRAPDvAAHDEAVQRLSAGIDRATRLVEQ 293
Cdd:COG0642    85 LLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELD-EEQREYLETILRSADRLLRLIND 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 294 LLTLARQEAqgtvqglqgmqgrhGAAAAAPADVDLREVVEQALADQAVAAQQHGLDMGLSESPQLRQsfaVAGDAQSLQM 373
Cdd:COG0642   164 LLDLSRLEA--------------GKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPT---VRGDPDRLRQ 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 374 LVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGqqaqGSGLGLAIVQTIA 453
Cdd:COG0642   227 VLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG----GTGLGLAIVKRIV 302
                         330       340
                  ....*....|....*....|....*
gi 2687004001 454 ERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:COG0642   303 ELHGGTIEVESEPG-KGTTFTVTLP 326
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
104-478 7.26e-52

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 180.52  E-value: 7.26e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 104 LRIFESALGAALPQMAVLGFADVPARGTVYRVFSLQTRSQVIQVAQDMRVRRTLARDAAWQSLLPIALLAPVLALAVWWV 183
Cdd:COG5002    30 LLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLA 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 184 VRSSLAPVQRVRRELATRRPQDLAPVPAEGLPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRSPLAALKLQLVA 263
Cdd:COG5002   110 LLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLEL 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 264 LQRAP--DVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAqgtvqglqgmqgrhGAAAAAPADVDLREVVEQALADQAV 341
Cdd:COG5002   190 LLDGAadDPEERREYLEIILEEAERLSRLVNDLLDLSRLES--------------GELKLEKEPVDLAELLEEVVEELRP 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 342 AAQQHGLDMGLSESPQLrqsFAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESEREL 421
Cdd:COG5002   256 LAEEKGIELELDLPEDP---LLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPR 332
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2687004001 422 VLRRFVRGPSAASagQQAQGSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVQVIWP 478
Cdd:COG5002   333 IFERFYRVDKSRS--RETGGTGLGLAIVKHIVEAHGGRIWVESEP-GKGTTFTITLP 386
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
224-478 6.34e-48

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 165.08  E-value: 6.34e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 224 ELNALLQRVGQAFEAQQHFVADAAHELRSPLAALKLQLVALQRAPDV--AAHDEAVQRLSAGIDRATRLVEQLLTLARQE 301
Cdd:COG2205     1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLspEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 302 AqgtvqglqgmqgrhGAAAAAPADVDLREVVEQALADQAVAAQQHGLDMGLSESPQLrqsFAVAGDAQSLQMLVRNLLDN 381
Cdd:COG2205    81 S--------------GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPEL---PLVYADPELLEQVLANLLDN 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 382 AVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGqqaqGSGLGLAIVQTIAERHGARLL 461
Cdd:COG2205   144 AIKYSPPGGTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEG----GTGLGLAIVKRIVEAHGGTIW 219
                         250
                  ....*....|....*..
gi 2687004001 462 LDRSPTlGGLRVQVIWP 478
Cdd:COG2205   220 VESEPG-GGTTFTVTLP 235
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
181-478 7.61e-44

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 157.82  E-value: 7.61e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 181 WWVVRSSLAPVQRVRRELATRRPQDLAPVPAEGLPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRSPLAALKLQ 260
Cdd:PRK10755   79 FQAVRWITRPLAELQKELEARTADNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLH 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 261 LVALQRapdvaAHDEAVQRLSAGIDRATRLVEQLLTLARQEaQGTVQGLQgmqgrhgaaaaapADVDLREVVEQALADQ- 339
Cdd:PRK10755  159 LELLEK-----QHHIDVAPLIARLDQMMHTVEQLLQLARAG-QSFSSGHY-------------QTVKLLEDVILPSQDEl 219
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 340 --AVAAQQHGLDMGLSESPqlrqsFAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAES 417
Cdd:PRK10755  220 seMLEQRQQTLLLPESAAD-----ITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDES 294
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2687004001 418 ERELVLRRFVRgpsaasAGQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLGGLRVQVIWP 478
Cdd:PRK10755  295 KCGELSKAFVR------MDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQERSGTRAWVWLP 349
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
364-477 3.38e-31

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 116.35  E-value: 3.38e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 364 VAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAqGRALVVEDSGPGIAESERELVLRRFVRgpsaaSAGQQAQGSG 443
Cdd:cd16940     7 VQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADD-GAVIRVEDNGPGIDEEELEALFERFYR-----SDGQNYGGSG 80
                          90       100       110
                  ....*....|....*....|....*....|....
gi 2687004001 444 LGLAIVQTIAERHGARLLLDRSPTlGGLRVQVIW 477
Cdd:cd16940    81 LGLSIVKRIVELHGGQIFLGNAQG-GGLEAWVRL 113
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
181-478 5.06e-31

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 124.96  E-value: 5.06e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 181 WWVVRsslaPVQRVRRELATRRPQDLAPVPAEGLPdevrplvaELNALlqrvGQAFEAQ----------QHFVADAAHEL 250
Cdd:PRK11100  204 WWLNR----SIRRLTRYADAVTEGKPVPLPKLGSS--------ELREL----AQALESMrvklegkayvEQYVQTLTHEL 267
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 251 RSPLAALKLQLVALQRAPDvaahDEAVQRLSAGID----RATRLVEQLLTLARQEAQgtvQGLQGMQgrhgaaaaapaDV 326
Cdd:PRK11100  268 KSPLAAIRGAAELLQEDPP----PEDRARFTGNILtqsaRLQQLIDRLLELARLEQR---QELEVLE-----------PV 329
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 327 DLREVVEQALADQAVAAQQHGLDMGLSESPqlrqsFAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALV 406
Cdd:PRK11100  330 ALAALLEELVEAREAQAAAKGITLRLRPDD-----ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALS 404
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2687004001 407 VEDSGPGIAESERELVLRRFVrgpSAASAGQQAQGSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVQVIWP 478
Cdd:PRK11100  405 VEDQGPGIPDYALPRIFERFY---SLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRP-EGGVLATLTLP 472
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
12-459 3.22e-28

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 117.19  E-value: 3.22e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001  12 LVARARSRLPGALGTRLLMFLGAAIVLTALLQGLLAYRNALLQTDTLFDYQMQQTAFALRAGLPVDARGRPQGTPPEDEN 91
Cdd:COG4251    55 LLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLAL 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001  92 HEFIVQVWTNEGLRIFESALGAALPQMAVLGFADVPARGTVYRVFSLQTRSQVIQVAQDMRVRRTLARDAAWQSLLPIAL 171
Cdd:COG4251   135 LLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLE 214
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 172 LAPVLALAVWWVVRSSLAPVQRVRRELATRRPQDLAPVPAEGLPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELR 251
Cdd:COG4251   215 AELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELEQFAYVASHDLR 294
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 252 SPLAALKLQLVALQRAPDVAAHDEA---VQRLSAGIDRATRLVEQLLTLARQEAQGtvqglqgmqgrhgaaaAAPADVDL 328
Cdd:COG4251   295 EPLRKISGFSQLLEEDYGDKLDEEGreyLERIRDAAERMQALIDDLLAYSRVGRQE----------------LEFEPVDL 358
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 329 REVVEQALADQAVAAQQHGLDMGLSESPQLRqsfavaGDAQSLQMLVRNLLDNAVKYVPQG--GRVDVGWRSDAQGRALV 406
Cdd:COG4251   359 NELLEEVLEDLEPRIEERGAEIEVGPLPTVR------GDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFS 432
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2687004001 407 VEDSGPGIAESERELVLRRFVRGPSAasagQQAQGSGLGLAIVQTIAERHGAR 459
Cdd:COG4251   433 VRDNGIGIDPEYAEKIFEIFQRLHSR----DEYEGTGIGLAIVKKIVERHGGR 481
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
366-479 3.89e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 107.73  E-value: 3.89e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001  366 GDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGqqaQGSGLG 445
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKI---GGTGLG 77
                           90       100       110
                   ....*....|....*....|....*....|....
gi 2687004001  446 LAIVQTIAERHGARLLLDRSPTlGGLRVQVIWPP 479
Cdd:smart00387  78 LSIVKKLVELHGGEISVESEPG-GGTTFTITLPL 110
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
181-478 2.74e-27

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 113.96  E-value: 2.74e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 181 WWVVRSSLAPVQRVRR--------ELATRrpqdlapVPAEGlPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRS 252
Cdd:PRK10549  182 FLLARGLLAPVKRLVEgthklaagDFTTR-------VTPTS-RDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRT 253
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 253 PLAALKLQLVALQ---RAPDvaahDEAVQRLSAGIDRATRLVEQLLTLARQEAqgtvqglqgmqgrhGAAAAAPADVDLR 329
Cdd:PRK10549  254 PLAVLRGELEAIQdgvRKFT----PESVASLQAEVGTLTKLVDDLHQLSLSDE--------------GALAYRKTPVDLV 315
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 330 EVVEQALADQAVAAQQHGLDMGLSespqLRQSFAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVED 409
Cdd:PRK10549  316 PLLEVAGGAFRERFASRGLTLQLS----LPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFAD 391
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2687004001 410 SGPGIAESERELVLRRFVRGPSaaSAGQQAQGSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVQVIWP 478
Cdd:PRK10549  392 SAPGVSDEQLQKLFERFYRTEG--SRNRASGGSGLGLAICLNIVEAHNGRIIAAHSP-FGGVSITVELP 457
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
371-477 1.39e-26

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 103.07  E-value: 1.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGqqaqGSGLGLAIVQ 450
Cdd:cd00075     1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGG----GTGLGLAIVR 76
                          90       100
                  ....*....|....*....|....*..
gi 2687004001 451 TIAERHGARLLLDRSPTlGGLRVQVIW 477
Cdd:cd00075    77 RIVEAHGGRITVESEPG-GGTTFTVTL 102
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
238-469 1.04e-25

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 108.94  E-value: 1.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 238 AQQHFVADAAHELRSPLAALKLQLVALQRAP-DVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAqgtvqglqgmqgrh 316
Cdd:PRK11006  203 ARRNFFANVSHELRTPLTVLQGYLEMMQDQPlEGALREKALHTMREQTQRMEGLVKQLLTLSKIEA-------------- 268
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 317 gaaaaaPADVDLREVVE-----QALADQAVAAQQHGLDMGLSESPQLRqsfaVAGDAQSLQMLVRNLLDNAVKYVPQGGR 391
Cdd:PRK11006  269 ------APTIDLNEKVDvpmmlRVLEREAQTLSQGKHTITFEVDNSLK----VFGNEDQLRSAISNLVYNAVNHTPEGTH 338
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2687004001 392 VDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASagQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:PRK11006  339 ITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARS--RQTGGSGLGLAIVKHALSHHDSRLEIESEVGKG 414
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
247-478 2.79e-25

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 107.74  E-value: 2.79e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 247 AHELRSPLAALKL--QLVALQRAPDVAAHDEAVQRLSAGI----DRATRLVEQLLTLARQEAqgtvqglqgmqgrhgaaa 320
Cdd:COG5000   209 AHEIKNPLTPIQLsaERLRRKLADKLEEDREDLERALDTIirqvDRLKRIVDEFLDFARLPE------------------ 270
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 321 AAPADVDLREVVEQALADQAVAAQQHGLDMGLSESPQLRQsfaVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDA 400
Cdd:COG5000   271 PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPE---VLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRRED 347
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 401 QGRALVVEDSGPGIAESERELVLRRFV--RgpsaasagqqAQGSGLGLAIVQTIAERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:COG5000   348 GRVRIEVSDNGPGIPEEVLERIFEPFFttK----------PKGTGLGLAIVKKIVEEHGGTIELESRPG-GGTTFTIRLP 416
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
366-478 1.23e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 92.43  E-value: 1.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 366 GDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRaLVVEDSGPGIAESERELVLRRFVRGPSaasagQQAQGSGLG 445
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELT-LTVEDNGIGIPPEDLPRIFEPFSTADK-----RGGGGTGLG 74
                          90       100       110
                  ....*....|....*....|....*....|...
gi 2687004001 446 LAIVQTIAERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:pfam02518  75 LSIVRKLVELLGGTITVESEPG-GGTTVTLTLP 106
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
104-469 1.62e-21

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 95.64  E-value: 1.62e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 104 LRIFESALGAALPQMAVLGFADVPARGTVYRVFSLQTRSQVIQVAQDMRVRRTLARDAAWQSLLPIALLAPVLALAVWWV 183
Cdd:COG4191     2 LRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 184 VRSSLAPVQRVRRELATRRPQDLAPVPAEGLPDEVRPLVAELNALLQRVGQAFEAQQ-----HFVADAAHELRSPLAALK 258
Cdd:COG4191    82 LGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKlaalgELAAGIAHEINNPLAAIL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 259 --LQLVA--LQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQgtvqglqgmqgrhgaaaaAPADVDLREVVEQ 334
Cdd:COG4191   162 gnAELLRrrLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEE------------------EREPVDLNELIDE 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 335 ALADQAVAAQQHGLDMGLSESPQLRQsfaVAGDAQSLQMLVRNLLDNAVKYVPQG--GRVDVGWRSDAQGRALVVEDSGP 412
Cdd:COG4191   224 ALELLRPRLKARGIEVELDLPPDLPP---VLGDPGQLEQVLLNLLINAIDAMEEGegGRITISTRREGDYVVISVRDNGP 300
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2687004001 413 GIAESERELVLRRFVrgpsaaSAGQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:COG4191   301 GIPPEVLERIFEPFF------TTKPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGG 351
PRK10604 PRK10604
sensor protein RstB; Provisional
247-478 1.74e-21

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 96.60  E-value: 1.74e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 247 AHELRSPLAALKLQLvALQRAPDvAAHDEAVQRlsaGIDRATRLVEQLLTLARQEAQGTVQGLQgmqgrhgaaaaapaDV 326
Cdd:PRK10604  220 AHELRTPLVRLRYRL-EMSDNLS-AAESQALNR---DIGQLEALIEELLTYARLDRPQNELHLS--------------EP 280
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 327 DLREVVEQALADQAVAAQQHGLDMGLSESPQLrqsfaVAGDAQSLQMLVRNLLDNAVKYVpqGGRVDVGWRSDAQGRALV 406
Cdd:PRK10604  281 DLPAWLSTHLADIQAVTPEKTVRLDTPHQGDY-----GALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLI 353
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2687004001 407 VEDSGPGIAESERELVLRRFVRgpSAASAGQQAQGSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVQVIWP 478
Cdd:PRK10604  354 VEDDGPGIPPEERERVFEPFVR--LDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESE-LGGARFSFSWP 422
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
181-483 1.15e-20

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 94.23  E-value: 1.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 181 WWVVRSSLAPVQRVRR---ELATrrpQDLAPVPA-EGLPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRSPLAA 256
Cdd:PRK09470  184 LWLAWSLAKPARKLKNaadEVAQ---GNLRQHPElETGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTR 260
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 257 LKLQLVALQRApdvaaHDEA--VQRLSAGIDRATRLVEQLLTLARQEAQGTVQglqgmqgrhgaaaaapadvdlREVV-- 332
Cdd:PRK09470  261 LQLATALLRRR-----QGESkeLERIETEAQRLDSMINDLLVLSRNQQKNHLE---------------------RETFka 314
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 333 ----EQALADQAVAAQQHGLDMGLSESPQlrqSFAVAGDAQSLQMLVRNLLDNAVKYVPQggRVDVGWRSDAQGRALVVE 408
Cdd:PRK09470  315 nslwSEVLEDAKFEAEQMGKSLTVSAPPG---PWPINGNPNALASALENIVRNALRYSHT--KIEVAFSVDKDGLTITVD 389
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2687004001 409 DSGPGIAESERELVLRRFVRGPSAASagQQAQGSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVqVIWPPVSGR 483
Cdd:PRK09470  390 DDGPGVPEEEREQIFRPFYRVDEARD--RESGGTGLGLAIVENAIQQHRGWVKAEDSP-LGGLRL-TIWLPLYKR 460
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
367-478 4.03e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 85.59  E-value: 4.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSaaSAGQQAQGSGLGL 446
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVES--SRNRASGGSGLGL 78
                          90       100       110
                  ....*....|....*....|....*....|..
gi 2687004001 447 AIVQTIAERHGARLLLDRSPtLGGLRVQVIWP 478
Cdd:cd16946    79 AICHNIALAHGGTISAEHSP-LGGLRLVLTLP 109
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
234-469 4.15e-20

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 91.45  E-value: 4.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 234 QAFEAQQHFVADAAHELRSPLAALK--LQLvaLQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAqgtvqglqg 311
Cdd:COG3852   130 EKLAAVGELAAGLAHEIRNPLTGIRgaAQL--LERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRP--------- 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 312 mqgrhgaaaAAPADVDLREVVEQALAdqaVAAQQHGLDMGLSE--SPQLRqsfAVAGDAQSLQMLVRNLLDNAVKYVPQG 389
Cdd:COG3852   199 ---------PEREPVNLHEVLERVLE---LLRAEAPKNIRIVRdyDPSLP---EVLGDPDQLIQVLLNLVRNAAEAMPEG 263
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 390 G------RVDVGWRSDAQGRALV----VEDSGPGIAESERELVLRRFVRGpsaasagqQAQGSGLGLAIVQTIAERHGAR 459
Cdd:COG3852   264 GtitirtRVERQVTLGGLRPRLYvrieVIDNGPGIPEEILDRIFEPFFTT--------KEKGTGLGLAIVQKIVEQHGGT 335
                         250
                  ....*....|
gi 2687004001 460 LLLDRSPTLG 469
Cdd:COG3852   336 IEVESEPGKG 345
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
344-476 2.20e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 84.22  E-value: 2.20e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 344 QQHGLDMGLSESPQLRqsfaVAGDAQSLQMLVRNLLDNAVKYVpqGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVL 423
Cdd:cd16954    15 QRKGVSISLDISPELR----FPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIF 88
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2687004001 424 RRFVRgpsaasAGQQAQGSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVQVI 476
Cdd:cd16954    89 QRGQR------LDEQRPGQGLGLAIAKEIVEQYGGELSLSDSP-LGGARFEVV 134
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
181-476 5.04e-18

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 86.61  E-value: 5.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 181 WWvvrsSLAPVQ---RVRRELATRRPQDLAPVPaeglPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRSPLAAL 257
Cdd:PRK10815  213 WW----SLRPIEalaKQVRELEEGEREQLDPNP----PRELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVL 284
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 258 KLQLVALqRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLArqeaqgtvqglqGMQGRHgaaaaapaDVDLREVVE-QAL 336
Cdd:PRK10815  285 QSTLRSL-RSGKQMSVEQAEPIMLEQISRISQQIGYYLHRA------------SMRSEH--------NLLSRELHSvAPL 343
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 337 ADQAVAA-----QQHGLDMGLSESPQLrqSFAvaGDAQSLQMLVRNLLDNAVKYVPQggRVDVGWRSDAQGRALVVEDSG 411
Cdd:PRK10815  344 LDNLTSAlnkvyQRKGVNITLDISPEI--TFV--GEKNDFMEVMGNVLDNACKYCLE--FVEISARQTDEHLHIVVEDDG 417
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2687004001 412 PGIAESERELVLRRfvrgpsaasaGQQAQ----GSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVQVI 476
Cdd:PRK10815  418 PGIPESKRELIFDR----------GQRADtlrpGQGLGLSVAREITEQYEGKISAGDSP-LGGARMEVI 475
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
371-479 1.09e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 78.40  E-value: 1.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASagQQAQGSGLGLAIVQ 450
Cdd:cd16952     1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERC--RNTGGTGLGLAIVK 78
                          90       100       110
                  ....*....|....*....|....*....|
gi 2687004001 451 TIAERHGARLLLdrSPTLG-GLRVQVIWPP 479
Cdd:cd16952    79 HVMSRHDARLLI--ASELGkGSRFTCLFPS 106
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
183-456 2.00e-17

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 84.44  E-value: 2.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 183 VVRSSLAPVQRVRRELATRRPQDL-APVPAEGLPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRSPLAALKLQL 261
Cdd:PRK09835  205 AVHKGHAPIRSVSRQIQNITSKDLdVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQT 284
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 262 -VALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQGTVQGLQGMqgrhgaaaaapadvDLREVVEQALADQA 340
Cdd:PRK09835  285 eIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKML--------------DLADEVGKVFDFFE 350
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 341 VAAQQHGLDMGLSESPQlrqsfAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERE 420
Cdd:PRK09835  351 AWAEERGVELRFVGDPC-----QVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLP 425
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2687004001 421 LVLRRFVR-GPSAASAGqqaQGSGLGLAIVQTIAERH 456
Cdd:PRK09835  426 RLFDRFYRvDPSRQRKG---EGSGIGLAIVKSIVVAH 459
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
367-478 7.72e-17

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 75.99  E-value: 7.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALV-VEDSGPGIAESERELVLRRFVRGpsAASAGQQAQGSGLG 445
Cdd:cd16925     1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLtVSDSGPGIPPNLREEIFERFRQG--DGSSTRAHGGTGLG 78
                          90       100       110
                  ....*....|....*....|....*....|...
gi 2687004001 446 LAIVQTIAERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:cd16925    79 LSIVKEFVELHGGTVTVSDAPG-GGALFQVELP 110
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
371-478 2.40e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 74.41  E-value: 2.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYvpQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGqqaqGSGLGLAIVQ 450
Cdd:cd16950     1 LKRVLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTS----GTGLGLAIVQ 74
                          90       100
                  ....*....|....*....|....*...
gi 2687004001 451 TIAERHGARLLLdRSPTLGGLRVQVIWP 478
Cdd:cd16950    75 RISDAHGGSLTL-ANRAGGGLCARIELP 101
envZ PRK09467
osmolarity sensor protein; Provisional
326-481 3.98e-16

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 80.34  E-value: 3.98e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 326 VDLREVVEQALadQAVAAQQHGLDMGLSESPQlrqsfAVAGDAQSLQMLVRNLLDNAVKYvpQGGRVDVGWRSDAQGRAL 405
Cdd:PRK09467  294 ADLNALLGEVI--AAESGYEREIETALQPGPI-----EVPMNPIAIKRALANLVVNAARY--GNGWIKVSSGTEGKRAWF 364
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2687004001 406 VVEDSGPGIAESERELVLRRFVRGPSAASagqqAQGSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVQvIWPPVS 481
Cdd:PRK09467  365 QVEDDGPGIPPEQLKHLFQPFTRGDSARG----SSGTGLGLAIVKRIVDQHNGKVELGNSE-EGGLSAR-AWLPLT 434
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
372-469 9.13e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 72.91  E-value: 9.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 372 QMLVrNLLDNAVKYVPQGG-RVDVGWRSDAQGRALV---VEDSGPGIAESERELVLRRFVRGPSaaSAGQQAQGSGLGLA 447
Cdd:cd16922     3 QILL-NLLGNAIKFTEEGEvTLRVSLEEEEEDGVQLrfsVEDTGIGIPEEQQARLFEPFSQADS--STTRKYGGTGLGLA 79
                          90       100
                  ....*....|....*....|..
gi 2687004001 448 IVQTIAERHGARLLLDRSPTLG 469
Cdd:cd16922    80 ISKKLVELMGGDISVESEPGQG 101
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
377-478 2.14e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 71.97  E-value: 2.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 377 NLLDNAVKYVPQggRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAgqQAQGSGLGLAIVQTIAERH 456
Cdd:cd16949     7 NVLRNALRYSPS--KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDR--ESGGTGLGLAIAERAIEQH 82
                          90       100
                  ....*....|....*....|..
gi 2687004001 457 GARLLLDRSPTlGGLRVQVIWP 478
Cdd:cd16949    83 GGKIKASNRKP-GGLRVRIWLP 103
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
371-478 2.51e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 71.69  E-value: 2.51e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQggRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSaaSAGQQAQGSGLGLAIVQ 450
Cdd:cd16939     1 MARALDNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDP--SRDRATGGFGLGLAIVH 76
                          90       100
                  ....*....|....*....|....*...
gi 2687004001 451 TIAERHGARLLLDRSPtLGGLRVQVIWP 478
Cdd:cd16939    77 RVALWHGGHVECDDSE-LGGACFRLTWP 103
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
371-469 3.42e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 68.51  E-value: 3.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQG--GRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVR--GPSAAsagqqaQGSGLGL 446
Cdd:cd16921     1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRlhSREEY------EGTGVGL 74
                          90       100
                  ....*....|....*....|...
gi 2687004001 447 AIVQTIAERHGARLLLDRSPTLG 469
Cdd:cd16921    75 AIVRKIIERHGGRIWLESEPGEG 97
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
241-483 4.60e-14

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 74.05  E-value: 4.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 241 HFVADAAHELRSPLAALK-LQLVALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQeaqgtvqglqgmqgrhgaA 319
Cdd:PRK10364  239 HLAAGVAHEIRNPLSSIKgLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKP------------------T 300
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 320 AAAPADVDLREVVEQALADQAVAAQQHGLDMGLSESPQLRqsfAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSD 399
Cdd:PRK10364  301 HLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLP---EIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASES 377
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 400 AQGRALVVEDSGPGIAESERELVLRRFVRgpsaasagQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLGGlrVQVIWPP 479
Cdd:PRK10364  378 GAGVKISVTDSGKGIAADQLEAIFTPYFT--------TKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGA--TFTLWLP 447

                  ....
gi 2687004001 480 VSGR 483
Cdd:PRK10364  448 VNIT 451
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
242-469 8.01e-14

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 73.85  E-value: 8.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 242 FVADAAHELRSPLAALKLQLVALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQGTVQglqgmqgrhgaaaa 321
Cdd:PRK11360  393 LVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQP-------------- 458
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 322 apadVDLREVVEQALADQAVAAQQHGLDMGLSESPQLRqsfAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQ 401
Cdd:PRK11360  459 ----VSLNALVEEVLQLFQTAGVQARVDFETELDNELP---PIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSD 531
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2687004001 402 GRALV-VEDSGPGIAESERELVLRRFVRgpsaasagQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:PRK11360  532 GQVAVsIEDNGCGIDPELLKKIFDPFFT--------TKAKGTGLGLALSQRIINAHGGDIEVESEPGVG 592
PRK10490 PRK10490
sensor protein KdpD; Provisional
248-478 1.70e-13

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 73.15  E-value: 1.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 248 HELRSPLAALKLQ--LVALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQGTVQGLQGMQgrhgaaaaapad 325
Cdd:PRK10490  673 HDLRTPLTVLFGQaeILTLDLASEGSPHARQASEIRQQVLNTTRLVNNLLDMARIQSGGFNLRKEWLT------------ 740
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 326 vdLREVVEQALADQAVAAQQHGLDMGLSESPQLrqsfaVAGDAQSLQMLVRNLLDNAVKYVpqGGRVDVGWRSDAQGRAL 405
Cdd:PRK10490  741 --LEEVVGSALQMLEPGLSGHPINLSLPEPLTL-----IHVDGPLFERVLINLLENAVKYA--GAQAEIGIDAHVEGERL 811
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2687004001 406 VVE--DSGPGIAESERELVLRRFVRGPSAASagqqAQGSGLGLAIVQTIAERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:PRK10490  812 QLDvwDNGPGIPPGQEQLIFDKFARGNKESA----IPGVGLGLAICRAIVEVHGGTIWAENRPE-GGACFRVTLP 881
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
367-466 4.02e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 65.56  E-value: 4.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASagqQAQGSGLGL 446
Cdd:cd16945     1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHS---GQKSTGLGL 77
                          90       100
                  ....*....|....*....|
gi 2687004001 447 AIVQTIAERHGARLLLDRSP 466
Cdd:cd16945    78 AFVQEVAQLHGGRITLRNRP 97
PRK15347 PRK15347
two component system sensor kinase;
336-479 6.54e-13

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 71.21  E-value: 6.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 336 LADQAVA-----AQQHGLDMGLSESPQLRQSFAVagDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQgRALVVEDS 410
Cdd:PRK15347  476 LLDQAMLtiqgpAQSKSLTLRTFVGAHVPLYLHL--DSLRLRQILVNLLGNAVKFTETGGIRLRVKRHEQQ-LCFTVEDT 552
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2687004001 411 GPGIAESERELVLRRFVRgpsaasAGQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLGG-----LRVQVIWPP 479
Cdd:PRK15347  553 GCGIDIQQQQQIFTPFYQ------ADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGScfslvLPLNEYAPP 620
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
217-469 3.12e-12

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 69.38  E-value: 3.12e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001  217 EVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRSPLAALK--LQLVAlqrapdvaahdeavqrlSAGIDRATRLveQL 294
Cdd:PRK09959   690 ETRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMgfLELLS-----------------GSGLSKEQRV--EA 750
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001  295 LTLArqeaQGTVQGLQGMQGR--------HGAAAAAPADVDLREVVEQALAD-QAVAAQQhglDMGLSESPQLRQSFAVA 365
Cdd:PRK09959   751 ISLA----YATGQSLLGLIGEildvdkieSGNYQLQPQWVDIPTLVQNTCHSfGAIAASK---SIALSCSSTFPDHYLVK 823
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001  366 GDAQSLQMLVRNLLDNAVKYVPQGG-RVDVGWRSDAQGRALV---VEDSGPGIAESERELVLRRFvrgpSAASAGQQAQG 441
Cdd:PRK09959   824 IDPQAFKQVLSNLLSNALKFTTEGAvKITTSLGHIDDNHAVIkmtIMDSGSGLSQEEQQQLFKRY----SQTSAGRQQTG 899
                          250       260
                   ....*....|....*....|....*...
gi 2687004001  442 SGLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:PRK09959   900 SGLGLMICKELIKNMQGDLSLESHPGIG 927
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
366-466 3.29e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 63.30  E-value: 3.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 366 GDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRR-FVRGPSAASAgqqAQGSGL 444
Cdd:cd16947    16 ANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERlYTLEDSRNSA---KQGNGL 92
                          90       100
                  ....*....|....*....|..
gi 2687004001 445 GLAIVQTIAERHGARLLLDRSP 466
Cdd:cd16947    93 GLTITKRLAESMGGSIYVNSKP 114
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
244-469 3.96e-12

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 68.22  E-value: 3.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 244 ADAAHELRSPLAALK--LQLvaLQRAPDVaaHDEAVQRLSAGIDRATRLVEQLLTLAR-QEAQGTVQGLQGMqgrhgaaa 320
Cdd:COG5805   292 AGIAHEIRNPLTSIKgfLQL--LQPGIED--KEEYFDIMLSELDRIESIISEFLALAKpQAVNKEKENINEL-------- 359
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 321 aapadvdLREVVEQALADqavaAQQHGLDMGLSEspqLRQSFAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDA 400
Cdd:COG5805   360 -------IQDVVTLLETE----AILHNIQIRLEL---LDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEED 425
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2687004001 401 QGRALVVEDSGPGIAESerelVLRRFvrgpsaasaGQ-----QAQGSGLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:COG5805   426 NSVIIRVIDEGIGIPEE----RLKKL---------GEpffttKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKG 486
PRK09303 PRK09303
histidine kinase;
214-469 5.09e-12

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 67.28  E-value: 5.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 214 LPDEVRPLVAELNALLQRVgqafEAQQHFVADAAHELRSPLAALKLQLVALQRA---PDVAAHDEAVQRLSAGIDRATRL 290
Cdd:PRK09303  130 LSDELFVLRQENETLLEQL----KFKDRVLAMLAHDLRTPLTAASLALETLELGqidEDTELKPALIEQLQDQARRQLEE 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 291 VEQLLTLARQEAQGTVQGLQGMQGRhgaaaaapadVDLR----EVVEQaLADQAVAAQQHGLDMGLSESPqlrqsfAVAG 366
Cdd:PRK09303  206 IERLITDLLEVGRTRWEALRFNPQK----------LDLGslcqEVILE-LEKRWLAKSLEIQTDIPSDLP------SVYA 268
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNAVKYVPQGGRVDVGW--RSDaQGRALVVEDSGPGIAESERELVLRRFVRGPSAasagQQAQGSGL 444
Cdd:PRK09303  269 DQERIRQVLLNLLDNAIKYTPEGGTITLSMlhRTT-QKVQVSICDTGPGIPEEEQERIFEDRVRLPRD----EGTEGYGI 343
                         250       260
                  ....*....|....*....|....*
gi 2687004001 445 GLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:PRK09303  344 GLSVCRRIVRVHYGQIWVDSEPGQG 368
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
375-469 2.85e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 59.99  E-value: 2.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 375 VRNLLDNAVKYV----PQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVlrrFVRGPSAASAGqqaqGSGLGLAIVQ 450
Cdd:cd16915     5 VGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKV---FERGVSTKGQG----ERGIGLALVR 77
                          90
                  ....*....|....*....
gi 2687004001 451 TIAERHGARLLLDRSPTLG 469
Cdd:cd16915    78 QSVERLGGSITVESEPGGG 96
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
367-475 1.10e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 58.63  E-value: 1.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGQQaqgSGLGL 446
Cdd:cd16975     1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGH---YGMGL 77
                          90       100
                  ....*....|....*....|....*....
gi 2687004001 447 AIVQTIAERHGARLLLDRSPTlGGLRVQV 475
Cdd:cd16975    78 YIAKNLVEKHGGSLIIENSQK-GGAEVTV 105
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
238-303 1.14e-10

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 57.22  E-value: 1.14e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2687004001 238 AQQHFVADAAHELRSPLAALKLQLVALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQ 303
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
237-299 1.16e-10

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 57.22  E-value: 1.16e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2687004001 237 EAQQHFVADAAHELRSPLAALKLQL-VALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLAR 299
Cdd:cd00082     2 QAKGEFLANVSHELRTPLTAIRGALeLLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
238-303 1.91e-10

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 56.42  E-value: 1.91e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2687004001  238 AQQHFVADAAHELRSPLAALKLQLVALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQ 303
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
343-469 3.48e-10

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 61.79  E-value: 3.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 343 AQQHGLDMGLSESPQLRQSFAVAGDaqslqmLVR---NLLDNAVKYV----PQGGRVDVGWRSDAQGRALVVEDSGPGIA 415
Cdd:COG3290   257 ARERGIDLTIDIDSDLPDLPLSDTD------LVTilgNLLDNAIEAVeklpEEERRVELSIRDDGDELVIEVEDSGPGIP 330
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2687004001 416 ESERELVlrrFVRGPSaasaGQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:COG3290   331 EELLEKI---FERGFS----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEG 377
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
371-460 7.95e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 55.86  E-value: 7.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGqqaqGSGLGLAIVQ 450
Cdd:cd16923     1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTE----GAGLGLSIAK 76
                          90
                  ....*....|
gi 2687004001 451 TIAERHGARL 460
Cdd:cd16923    77 AIIELHGGSA 86
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
371-470 2.09e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 54.71  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQGGR----VDVGWRSDAQGR-ALVVEDSGPGIAESERELVLRRFVRgpsaasagQQAQGSGLG 445
Cdd:cd16920     1 IQQVLINLVRNGIEAMSEGGCerreLTIRTSPADDRAvTISVKDTGPGIAEEVAGQLFDPFYT--------TKSEGLGMG 72
                          90       100
                  ....*....|....*....|....*
gi 2687004001 446 LAIVQTIAERHGARllLDRSPTLGG 470
Cdd:cd16920    73 LSICRSIIEAHGGR--LSVESPAGG 95
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
371-457 2.60e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 54.89  E-value: 2.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVP-QGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRF-VRGPSAASAGQQaqgSGLGLAI 448
Cdd:cd16953     1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFyTERPANEAFGQH---SGLGLSI 77

                  ....*....
gi 2687004001 449 VQTIAERHG 457
Cdd:cd16953    78 SRQIIEAHG 86
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
367-457 6.24e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 53.44  E-value: 6.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESErelVLRRFVRGPSAASAGQQAQGSGLGL 446
Cdd:cd16948     2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEED---LPRVFDKGFTGENGRNFQESTGMGL 78
                          90
                  ....*....|.
gi 2687004001 447 AIVQTIAERHG 457
Cdd:cd16948    79 YLVKKLCDKLG 89
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
367-478 1.24e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 52.54  E-value: 1.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNA------VKYVPQGGRVDVgwRSDAQGR-ALVVEDSGPGIAESERELVLRRFVRgpsaasagQQA 439
Cdd:cd16944     1 DTTQISQVLTNILKNAaeaiegRPSDVGEVRIRV--EADQDGRiVLIVCDNGKGFPREMRHRATEPYVT--------TRP 70
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2687004001 440 QGSGLGLAIVQTIAERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:cd16944    71 KGTGLGLAIVKKIMEEHGGRISLSNREA-GGACIRIILP 108
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
368-478 2.37e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 51.65  E-value: 2.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 368 AQSLQMLVrNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVrgpsaaSAGQQAQGSGLGLA 447
Cdd:cd16943     2 SQLNQVLL-NLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF------TTKPVGEGTGLGLS 74
                          90       100       110
                  ....*....|....*....|....*....|.
gi 2687004001 448 IVQTIAERHGARLLLdRSPTLGGLRVQVIWP 478
Cdd:cd16943    75 LSYRIIQKHGGTIRV-ASVPGGGTRFTIILP 104
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
371-462 1.15e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 49.76  E-value: 1.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVP--QGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVrgpsaaSAGQQAQGSGLGLAI 448
Cdd:cd16976     1 IQQVLMNLLQNALDAMGkvENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF------TTKPVGKGTGLGLSI 74
                          90
                  ....*....|....
gi 2687004001 449 VQTIAERHGARLLL 462
Cdd:cd16976    75 SYGIVEEHGGRLSV 88
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
229-460 2.28e-07

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 53.05  E-value: 2.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 229 LQRVGQafeaqqhFVADAAHELRSPLAALK--LQLVALqrapdvAAHDEavQRLSAGI-----DRATRLVEQLLTLARQE 301
Cdd:COG5809   267 LSVVGE-------LAAGIAHEIRNPLTSLKgfIQLLKD------TIDEE--QKTYLDImlselDRIESIISEFLVLAKPQ 331
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 302 AqgtvqglqgMQGRHgaaaaapadVDLREVVEQALA---DQAV-------AAQQHGLDMGLSESPQLRQSFAvagdaqsl 371
Cdd:COG5809   332 A---------IKYEP---------KDLNTLIEEVIPllqPQALlknvqieLELEDDIPDILGDENQLKQVFI-------- 385
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 372 qmlvrNLLDNAVKYVPQGGRVDVGWRSDAQGRALV-VEDSGPGIAESerelVLRRFvrgpsaasaGQ-----QAQGSGLG 445
Cdd:COG5809   386 -----NLLKNAIEAMPEGGNITIETKAEDDDKVVIsVTDEGCGIPEE----RLKKL---------GEpfyttKEKGTGLG 447
                         250
                  ....*....|....*
gi 2687004001 446 LAIVQTIAERHGARL 460
Cdd:COG5809   448 LMVSYKIIEEHGGKI 462
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
212-469 5.03e-07

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 52.60  E-value: 5.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 212 EGLPDEVRPLVAELNALLQRVGQAF-------EAQQHFVADAAHELRSPLAAL--KLQLVALQraPDVAAHDEAVQRLSA 282
Cdd:PRK11466  410 EQLAAQVKARTAELQELVIEHRQARaeaekasQAKSAFLAAMSHEIRTPLYGIlgTAQLLADN--PALNAQRDDLRAITD 487
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 283 GIDRATRLVEQLLTLARQEAQGTVQGLQgmqgrhgaaaaaPADVDLREVVEQALADQAVAAQQHGLDMGLSESPQLRQsf 362
Cdd:PRK11466  488 SGESLLTILNDILDYSAIEAGGKNVSVS------------DEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLPT-- 553
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 363 AVAGDAQSLQMLVRNLLDNAVKYVPQGgRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRgpsaasAGQQAQGS 442
Cdd:PRK11466  554 ALMGDPRRIRQVITNLLSNALRFTDEG-SIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQ------VSGKRGGT 626
                         250       260
                  ....*....|....*....|....*..
gi 2687004001 443 GLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:PRK11466  627 GLGLTISSRLAQAMGGELSATSTPEVG 653
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
371-466 5.83e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 47.78  E-value: 5.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQGG-------RVDVGWRSDAQGRALV----VEDSGPGIAESERELVLRRFVRGpsaasagqQA 439
Cdd:cd16918     1 LIQVFLNLVRNAAQALAGSGgeiilrtRTQRQVTLGHPRHRLAlrvsVIDNGPGIPPDLQDTIFYPMVSG--------RE 72
                          90       100
                  ....*....|....*....|....*..
gi 2687004001 440 QGSGLGLAIVQTIAERHGARLLLDRSP 466
Cdd:cd16918    73 NGTGLGLAIAQNIVSQHGGVIECDSQP 99
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
247-462 2.04e-06

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 50.46  E-value: 2.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 247 AHELRSPLAALKLQLVALQRApdvaAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQGTVQGLQGMQgrhgaaaaapaDV 326
Cdd:COG4192   441 AHELNQPLNAMSMYLFSAKKA----LEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQ-----------PV 505
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 327 DLREVVEQALADQAVAAQQHGLDMGLSESPQlrqsfaVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALV 406
Cdd:COG4192   506 DLRQVIEQAWELVESRAKPQQITLHIPDDLM------VQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVA 579
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2687004001 407 VEDSGPGIAESERelVLRRFVRGPSAasagqqaqGSGLGLAIVQTIAERHGARLLL 462
Cdd:COG4192   580 ISDNGNGWPLVDK--LFTPFTTTKEV--------GLGLGLSICRSIMQQFGGDLYL 625
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
343-453 3.27e-06

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 49.55  E-value: 3.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 343 AQQHGLDMGLSESPQLRQsfAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELV 422
Cdd:PRK11091  373 AEQKGLRFDLEPLLPLPH--KVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYEEGDMLTFEVEDSGIGIPEDELDKI 450
                          90       100       110
                  ....*....|....*....|....*....|.
gi 2687004001 423 LRRFVRGPSAAsAGQQAQGSGLGLAIVQTIA 453
Cdd:PRK11091  451 FAMYYQVKDSH-GGKPATGTGIGLAVSKRLA 480
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
327-457 3.81e-06

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 49.46  E-value: 3.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 327 DLREVVEQALADQAVAAQQHGLDMGLSESPQLRQSfaVAGDAQSLQMLVRNLLDNAVKYVPQGG-RVDVGWRSDAQGRAL 405
Cdd:PRK11107  367 SLRETLDEVVTLLAHSAHEKGLELTLNIDPDVPDN--VIGDPLRLQQIITNLVGNAIKFTESGNiDILVELRALSNTKVQ 444
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2687004001 406 V---VEDSGPGIAESERELVLRRFvrGPSAASAGQQAQGSGLGLAIVQTIAERHG 457
Cdd:PRK11107  445 LevqIRDTGIGISERQQSQLFQAF--RQADASISRRHGGTGLGLVITQKLVNEMG 497
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
8-478 5.21e-05

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 45.67  E-value: 5.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001   8 LVSSLVARARSRLPGALGTRLLMFLGAAIVLTALLQGLLAYRNALLQTDTLFDYQMQQTAFALRAGLPVDARGRPQGTPP 87
Cdd:COG3920     1 LLLALLLLLLLALAALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001  88 EDENHEFIVQVWTNEGLRIFESALGAALPQMAVLGFADVPARGTVYRVFSLQTRSQVIQVAQDMRVRRTLARDAAWQSLL 167
Cdd:COG3920    81 LLALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 168 PIALLAPVLALAVWWVVRSSLAPVQRVRRELATRRPQDLAPVPAEGLPDEVRPLVAELNALLQRVGQAFEAQQHFVADAA 247
Cdd:COG3920   161 LLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 248 HELRSPLAALKLQLVALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQ--------------GTVQGLQGMQ 313
Cdd:COG3920   241 LERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKElllrelhhrvknnlQVVSSLLRLQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 314 GRHGA--------------------------AAAAPADVDLREVVEQALADQAVAAQQHGLDMGLS-ESPQLRqsfavAG 366
Cdd:COG3920   321 ARRADdpearealeesqnriqalalvhellyQSEDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDgPDVELP-----AD 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNAVKY---VPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERElvlrrfvrgpsaasagqqAQGSG 443
Cdd:COG3920   396 AAVPLGLILNELVTNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDVDP------------------PARKG 457
                         490       500       510
                  ....*....|....*....|....*....|....*
gi 2687004001 444 LGLAIVQTIAERHGARLLLDRSPtlgGLRVQVIWP 478
Cdd:COG3920   458 LGLRLIRALVRQLGGTLELDRPE---GTRVRITFP 489
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
181-478 7.32e-05

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 45.01  E-value: 7.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 181 WWVVRSSLAPVQRVRRELATRRPQDLAPVPAEGlPDEVRPLVAELNALLQRVGQAFEAQQhfvadaahELRspLAALKLQ 260
Cdd:COG2972   175 YLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSG-NDEIGILARSFNEMVERIKELIEEVY--------ELE--LEKKEAE 243
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 261 LVALQRA--PdvaaHD-----EAVQRL--SAGIDRATRLVEQLLTLARQeaqgTVQGLQGMqgrhgaaaaapadVDLREv 331
Cdd:COG2972   244 LKALQAQinP----HFlfntlNSIRWLaeLEDPEEAEEMLEALSKLLRY----SLSKGDEL-------------VTLEE- 301
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 332 vEQALADQAVAAQQhgLDMGlsesPQLRQSFAVAGDAQSLQMLVR---NLLDNAVKY----VPQGGRVDVGWRSDAQGRA 404
Cdd:COG2972   302 -ELELIKSYLEIQK--LRFG----DRLEVEIEIDEELLDLLIPKLilqPLVENAIEHgiepKEGGGTIRISIRKEGDRLV 374
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2687004001 405 LVVEDSGPGIAESERELVLRRFvrgpsaasaGQQAQGSGLGLAIVQT-IAERHGARLLLD-RSPTLGGLRVQVIWP 478
Cdd:COG2972   375 ITVEDNGVGMPEEKLEKLLEEL---------SSKGEGRGIGLRNVRErLKLYYGEEYGLEiESEPGEGTTVTIRIP 441
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
371-469 6.51e-04

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 39.29  E-value: 6.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQGGRVDVGWRSD-------------AQGR--ALVVEDSGPGIAESERELVLRRFVrgpsaaSA 435
Cdd:cd16919     1 LELAILNLAVNARDAMPEGGRLTIETSNQrvdadyalnyrdlIPGNyvCLEVSDTGSGMPAEVLRRAFEPFF------TT 74
                          90       100       110
                  ....*....|....*....|....*....|....
gi 2687004001 436 GQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:cd16919    75 KEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVG 108
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
363-448 7.41e-04

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 42.27  E-value: 7.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 363 AVAGDAQSLQMLVRNLLDNAVKYVPQGGRV-DVGWRSDAqgRALVVEDSGPGIAESErelVLRRFVRGPSAASAGQQA-Q 440
Cdd:PRK10841  555 ALNGDPMRLQQVISNLLSNAIKFTDTGCIVlHVRVDGDY--LSFRVRDTGVGIPAKE---VVRLFDPFFQVGTGVQRNfQ 629

                  ....*...
gi 2687004001 441 GSGLGLAI 448
Cdd:PRK10841  630 GTGLGLAI 637
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
217-482 1.85e-03

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 40.82  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 217 EVRPLVAELNALLQRVGQA--FEAQQHFVADAAHELRSPLAAL----KLQLVALQRAPDVAAHdeaVQRLSAGIDRATRL 290
Cdd:PRK13837  426 ERRRLETERDALERRLEHArrLEAVGTLASGIAHNFNNILGAIlgyaEMALNKLARHSRAARY---IDEIISAGARARLI 502
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 291 VEQLLTLARQEAQGTVQglqgmqgrhgaaaaapadVDLREVVEQALADQAVAAQQH-GLDMGLSESPQLrqsfaVAGDAQ 369
Cdd:PRK13837  503 IDQILAFGRKGERNTKP------------------FDLSELVTEIAPLLRVSLPPGvELDFDQDQEPAV-----VEGNPA 559
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 370 SLQMLVRNLLDNAVKYVPQGGRVDV--------GWRSDAQGRA-------LVVEDSGPGIAESERELVLRRFVRgpsaas 434
Cdd:PRK13837  560 ELQQVLMNLCSNAAQAMDGAGRVDIslsraklrAPKVLSHGVLppgryvlLRVSDTGAGIDEAVLPHIFEPFFT------ 633
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2687004001 435 agQQAQGSGLGLAIVQTIAERHGARllLDRSPTLG-GLRVQVIWPPVSG 482
Cdd:PRK13837  634 --TRAGGTGLGLATVHGIVSAHAGY--IDVQSTVGrGTRFDVYLPPSSK 678
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
277-471 3.66e-03

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 39.82  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 277 VQRLSAGIDRATRLVEQLLTLaRQEA---QGTVQGLQGMQ----GRHGAAAAAPADVDLREVVEQALADQAVA------- 342
Cdd:PRK15053  325 ISTLNAQLTQIKQYVESLRTL-RHEHlnwMSTLNGLLQMKeydrVLEMVQGESQAQQQLIDSLREAFADRQVAgllfgkv 403
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 343 --AQQHGLDMGLSESPQLRQsFAVAGDAQSLQMLVRNLLDNAVK---YVPQGGRVDVGWRSDaQGRALVVE--DSGPGIA 415
Cdd:PRK15053  404 qrARELGLKMVIVPGSQLSQ-LPPGLDSTEFAAIVGNLLDNAFEaslRSDEGNKIVELFLSD-EGDDVVIEvaDQGCGVP 481
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2687004001 416 ESERELVlrrFVRGPSAASagQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLGGL 471
Cdd:PRK15053  482 ESLRDKI---FEQGVSTRA--DEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTL 532
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
371-477 8.53e-03

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 35.71  E-value: 8.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKY---VPQGGRVDVGWRSDAQGRALVVEDSGPGIAeserelvlRRFVRGPSAAsagqqAQGSGLGLA 447
Cdd:cd16936     1 VELAVSEAVTNAVRHayrHDGPGPVRLELDLDPDRLRVEVTDSGPGFD--------PLRPADPDAG-----LREGGRGLA 67
                          90       100       110
                  ....*....|....*....|....*....|
gi 2687004001 448 IVQTIAERHGARllldrsPTLGGLRVQVIW 477
Cdd:cd16936    68 LIRALMDEVGYR------RTPGGKTVWLEL 91
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
273-478 8.92e-03

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 38.06  E-value: 8.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 273 HDEAVQRLSA---GIDRATRLVEQLLTLARQEAQGTVQGLQGMQGR-----HGAAAAAPADVDLREVVEQALADqavAAQ 344
Cdd:COG4585    62 HDGVGQSLSAiklQLEAARRLLDADPEAAREELEEIRELAREALAElrrlvRGLRPPALDDLGLAAALEELAER---LLR 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 345 QHGLDMGLSESPQLRQSFAVAGDAqsLQMLVRNLLDNAVKYVpQGGRVDVGWRSDAQGRALVVEDSGPGIAEserelvlr 424
Cdd:COG4585   139 AAGIRVELDVDGDPDRLPPEVELA--LYRIVQEALTNALKHA-GATRVTVTLEVDDGELTLTVRDDGVGFDP-------- 207
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2687004001 425 rfvrgpsaasagQQAQGSGLGLAIVQTIAERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:COG4585   208 ------------EAAPGGGLGLRGMRERAEALGGTLTIGSAPG-GGTRVRATLP 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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