|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
144-477 |
1.24e-70 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 231.46 E-value: 1.24e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 144 VIQVAQDMRVRRTLARDAAWQSLLPIALLAPVLALAVWWVVRSSLAPVQRVRRELATRRPQDLAPVPAEGLPDEVRPLVA 223
Cdd:PRK10337 142 RIVVGQEWEYREDMALAIVAGQLIPWLVALPIMLIILMVLLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVE 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 224 ELNALLQRVGQAFEAQQHFVADAAHELRSPLAALKLQL-VALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEA 302
Cdd:PRK10337 222 ALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTeVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDS 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 303 QGTVQGLQgmqgrhgaaaaapaDVDLREVVEQALADQAVAAQQHGLDMGLS--ESPQLRQsfavaGDAQSLQMLVRNLLD 380
Cdd:PRK10337 302 LDNLQDVA--------------EIPLEDLLQSAVMDIYHTAQQAGIDVRLTlnAHPVIRT-----GQPLLLSLLVRNLLD 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 381 NAVKYVPQGGRVDVGWRSdaqgRALVVEDSGPGIAESERELVLRRFVRGPsaasaGQQAQGSGLGLAIVQTIAERHGARL 460
Cdd:PRK10337 363 NAIRYSPQGSVVDVTLNA----RNFTVRDNGPGVTPEALARIGERFYRPP-----GQEATGSGLGLSIVRRIAKLHGMNV 433
|
330
....*....|....*..
gi 2687004001 461 LLDRSPTlGGLRVQVIW 477
Cdd:PRK10337 434 SFGNAPE-GGFEAKVSW 449
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
134-478 |
2.43e-54 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 185.11 E-value: 2.43e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 134 RVFSLQTRSQVIQVAQDMRVRRTLARDAAWQSLLPIALLAPVLALAVWWVVRSSLAPVQRVRRELATRRPQDLAPVPAEG 213
Cdd:COG0642 5 LLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 214 LPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRSPLAALKLQLVALQRAPDvAAHDEAVQRLSAGIDRATRLVEQ 293
Cdd:COG0642 85 LLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELD-EEQREYLETILRSADRLLRLIND 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 294 LLTLARQEAqgtvqglqgmqgrhGAAAAAPADVDLREVVEQALADQAVAAQQHGLDMGLSESPQLRQsfaVAGDAQSLQM 373
Cdd:COG0642 164 LLDLSRLEA--------------GKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPT---VRGDPDRLRQ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 374 LVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGqqaqGSGLGLAIVQTIA 453
Cdd:COG0642 227 VLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG----GTGLGLAIVKRIV 302
|
330 340
....*....|....*....|....*
gi 2687004001 454 ERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:COG0642 303 ELHGGTIEVESEPG-KGTTFTVTLP 326
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
104-478 |
7.26e-52 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 180.52 E-value: 7.26e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 104 LRIFESALGAALPQMAVLGFADVPARGTVYRVFSLQTRSQVIQVAQDMRVRRTLARDAAWQSLLPIALLAPVLALAVWWV 183
Cdd:COG5002 30 LLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 184 VRSSLAPVQRVRRELATRRPQDLAPVPAEGLPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRSPLAALKLQLVA 263
Cdd:COG5002 110 LLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLEL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 264 LQRAP--DVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAqgtvqglqgmqgrhGAAAAAPADVDLREVVEQALADQAV 341
Cdd:COG5002 190 LLDGAadDPEERREYLEIILEEAERLSRLVNDLLDLSRLES--------------GELKLEKEPVDLAELLEEVVEELRP 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 342 AAQQHGLDMGLSESPQLrqsFAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESEREL 421
Cdd:COG5002 256 LAEEKGIELELDLPEDP---LLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPR 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2687004001 422 VLRRFVRGPSAASagQQAQGSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVQVIWP 478
Cdd:COG5002 333 IFERFYRVDKSRS--RETGGTGLGLAIVKHIVEAHGGRIWVESEP-GKGTTFTITLP 386
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
224-478 |
6.34e-48 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 165.08 E-value: 6.34e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 224 ELNALLQRVGQAFEAQQHFVADAAHELRSPLAALKLQLVALQRAPDV--AAHDEAVQRLSAGIDRATRLVEQLLTLARQE 301
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLspEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 302 AqgtvqglqgmqgrhGAAAAAPADVDLREVVEQALADQAVAAQQHGLDMGLSESPQLrqsFAVAGDAQSLQMLVRNLLDN 381
Cdd:COG2205 81 S--------------GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPEL---PLVYADPELLEQVLANLLDN 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 382 AVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGqqaqGSGLGLAIVQTIAERHGARLL 461
Cdd:COG2205 144 AIKYSPPGGTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEG----GTGLGLAIVKRIVEAHGGTIW 219
|
250
....*....|....*..
gi 2687004001 462 LDRSPTlGGLRVQVIWP 478
Cdd:COG2205 220 VESEPG-GGTTFTVTLP 235
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
181-478 |
7.61e-44 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 157.82 E-value: 7.61e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 181 WWVVRSSLAPVQRVRRELATRRPQDLAPVPAEGLPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRSPLAALKLQ 260
Cdd:PRK10755 79 FQAVRWITRPLAELQKELEARTADNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLH 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 261 LVALQRapdvaAHDEAVQRLSAGIDRATRLVEQLLTLARQEaQGTVQGLQgmqgrhgaaaaapADVDLREVVEQALADQ- 339
Cdd:PRK10755 159 LELLEK-----QHHIDVAPLIARLDQMMHTVEQLLQLARAG-QSFSSGHY-------------QTVKLLEDVILPSQDEl 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 340 --AVAAQQHGLDMGLSESPqlrqsFAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAES 417
Cdd:PRK10755 220 seMLEQRQQTLLLPESAAD-----ITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDES 294
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2687004001 418 ERELVLRRFVRgpsaasAGQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLGGLRVQVIWP 478
Cdd:PRK10755 295 KCGELSKAFVR------MDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQERSGTRAWVWLP 349
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-477 |
3.38e-31 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 116.35 E-value: 3.38e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 364 VAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAqGRALVVEDSGPGIAESERELVLRRFVRgpsaaSAGQQAQGSG 443
Cdd:cd16940 7 VQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADD-GAVIRVEDNGPGIDEEELEALFERFYR-----SDGQNYGGSG 80
|
90 100 110
....*....|....*....|....*....|....
gi 2687004001 444 LGLAIVQTIAERHGARLLLDRSPTlGGLRVQVIW 477
Cdd:cd16940 81 LGLSIVKRIVELHGGQIFLGNAQG-GGLEAWVRL 113
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
181-478 |
5.06e-31 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 124.96 E-value: 5.06e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 181 WWVVRsslaPVQRVRRELATRRPQDLAPVPAEGLPdevrplvaELNALlqrvGQAFEAQ----------QHFVADAAHEL 250
Cdd:PRK11100 204 WWLNR----SIRRLTRYADAVTEGKPVPLPKLGSS--------ELREL----AQALESMrvklegkayvEQYVQTLTHEL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 251 RSPLAALKLQLVALQRAPDvaahDEAVQRLSAGID----RATRLVEQLLTLARQEAQgtvQGLQGMQgrhgaaaaapaDV 326
Cdd:PRK11100 268 KSPLAAIRGAAELLQEDPP----PEDRARFTGNILtqsaRLQQLIDRLLELARLEQR---QELEVLE-----------PV 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 327 DLREVVEQALADQAVAAQQHGLDMGLSESPqlrqsFAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALV 406
Cdd:PRK11100 330 ALAALLEELVEAREAQAAAKGITLRLRPDD-----ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALS 404
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2687004001 407 VEDSGPGIAESERELVLRRFVrgpSAASAGQQAQGSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVQVIWP 478
Cdd:PRK11100 405 VEDQGPGIPDYALPRIFERFY---SLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRP-EGGVLATLTLP 472
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
12-459 |
3.22e-28 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 117.19 E-value: 3.22e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 12 LVARARSRLPGALGTRLLMFLGAAIVLTALLQGLLAYRNALLQTDTLFDYQMQQTAFALRAGLPVDARGRPQGTPPEDEN 91
Cdd:COG4251 55 LLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLAL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 92 HEFIVQVWTNEGLRIFESALGAALPQMAVLGFADVPARGTVYRVFSLQTRSQVIQVAQDMRVRRTLARDAAWQSLLPIAL 171
Cdd:COG4251 135 LLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLE 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 172 LAPVLALAVWWVVRSSLAPVQRVRRELATRRPQDLAPVPAEGLPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELR 251
Cdd:COG4251 215 AELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELEQFAYVASHDLR 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 252 SPLAALKLQLVALQRAPDVAAHDEA---VQRLSAGIDRATRLVEQLLTLARQEAQGtvqglqgmqgrhgaaaAAPADVDL 328
Cdd:COG4251 295 EPLRKISGFSQLLEEDYGDKLDEEGreyLERIRDAAERMQALIDDLLAYSRVGRQE----------------LEFEPVDL 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 329 REVVEQALADQAVAAQQHGLDMGLSESPQLRqsfavaGDAQSLQMLVRNLLDNAVKYVPQG--GRVDVGWRSDAQGRALV 406
Cdd:COG4251 359 NELLEEVLEDLEPRIEERGAEIEVGPLPTVR------GDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFS 432
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 2687004001 407 VEDSGPGIAESERELVLRRFVRGPSAasagQQAQGSGLGLAIVQTIAERHGAR 459
Cdd:COG4251 433 VRDNGIGIDPEYAEKIFEIFQRLHSR----DEYEGTGIGLAIVKKIVERHGGR 481
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
366-479 |
3.89e-28 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 107.73 E-value: 3.89e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 366 GDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGqqaQGSGLG 445
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKI---GGTGLG 77
|
90 100 110
....*....|....*....|....*....|....
gi 2687004001 446 LAIVQTIAERHGARLLLDRSPTlGGLRVQVIWPP 479
Cdd:smart00387 78 LSIVKKLVELHGGEISVESEPG-GGTTFTITLPL 110
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
181-478 |
2.74e-27 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 113.96 E-value: 2.74e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 181 WWVVRSSLAPVQRVRR--------ELATRrpqdlapVPAEGlPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRS 252
Cdd:PRK10549 182 FLLARGLLAPVKRLVEgthklaagDFTTR-------VTPTS-RDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRT 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 253 PLAALKLQLVALQ---RAPDvaahDEAVQRLSAGIDRATRLVEQLLTLARQEAqgtvqglqgmqgrhGAAAAAPADVDLR 329
Cdd:PRK10549 254 PLAVLRGELEAIQdgvRKFT----PESVASLQAEVGTLTKLVDDLHQLSLSDE--------------GALAYRKTPVDLV 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 330 EVVEQALADQAVAAQQHGLDMGLSespqLRQSFAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVED 409
Cdd:PRK10549 316 PLLEVAGGAFRERFASRGLTLQLS----LPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFAD 391
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2687004001 410 SGPGIAESERELVLRRFVRGPSaaSAGQQAQGSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVQVIWP 478
Cdd:PRK10549 392 SAPGVSDEQLQKLFERFYRTEG--SRNRASGGSGLGLAICLNIVEAHNGRIIAAHSP-FGGVSITVELP 457
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
371-477 |
1.39e-26 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 103.07 E-value: 1.39e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGqqaqGSGLGLAIVQ 450
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGG----GTGLGLAIVR 76
|
90 100
....*....|....*....|....*..
gi 2687004001 451 TIAERHGARLLLDRSPTlGGLRVQVIW 477
Cdd:cd00075 77 RIVEAHGGRITVESEPG-GGTTFTVTL 102
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
238-469 |
1.04e-25 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 108.94 E-value: 1.04e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 238 AQQHFVADAAHELRSPLAALKLQLVALQRAP-DVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAqgtvqglqgmqgrh 316
Cdd:PRK11006 203 ARRNFFANVSHELRTPLTVLQGYLEMMQDQPlEGALREKALHTMREQTQRMEGLVKQLLTLSKIEA-------------- 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 317 gaaaaaPADVDLREVVE-----QALADQAVAAQQHGLDMGLSESPQLRqsfaVAGDAQSLQMLVRNLLDNAVKYVPQGGR 391
Cdd:PRK11006 269 ------APTIDLNEKVDvpmmlRVLEREAQTLSQGKHTITFEVDNSLK----VFGNEDQLRSAISNLVYNAVNHTPEGTH 338
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2687004001 392 VDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASagQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:PRK11006 339 ITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARS--RQTGGSGLGLAIVKHALSHHDSRLEIESEVGKG 414
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
247-478 |
2.79e-25 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 107.74 E-value: 2.79e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 247 AHELRSPLAALKL--QLVALQRAPDVAAHDEAVQRLSAGI----DRATRLVEQLLTLARQEAqgtvqglqgmqgrhgaaa 320
Cdd:COG5000 209 AHEIKNPLTPIQLsaERLRRKLADKLEEDREDLERALDTIirqvDRLKRIVDEFLDFARLPE------------------ 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 321 AAPADVDLREVVEQALADQAVAAQQHGLDMGLSESPQLRQsfaVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDA 400
Cdd:COG5000 271 PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPE---VLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRRED 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 401 QGRALVVEDSGPGIAESERELVLRRFV--RgpsaasagqqAQGSGLGLAIVQTIAERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:COG5000 348 GRVRIEVSDNGPGIPEEVLERIFEPFFttK----------PKGTGLGLAIVKKIVEEHGGTIELESRPG-GGTTFTIRLP 416
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
366-478 |
1.23e-22 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 92.43 E-value: 1.23e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 366 GDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRaLVVEDSGPGIAESERELVLRRFVRGPSaasagQQAQGSGLG 445
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELT-LTVEDNGIGIPPEDLPRIFEPFSTADK-----RGGGGTGLG 74
|
90 100 110
....*....|....*....|....*....|...
gi 2687004001 446 LAIVQTIAERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:pfam02518 75 LSIVRKLVELLGGTITVESEPG-GGTTVTLTLP 106
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
104-469 |
1.62e-21 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 95.64 E-value: 1.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 104 LRIFESALGAALPQMAVLGFADVPARGTVYRVFSLQTRSQVIQVAQDMRVRRTLARDAAWQSLLPIALLAPVLALAVWWV 183
Cdd:COG4191 2 LRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 184 VRSSLAPVQRVRRELATRRPQDLAPVPAEGLPDEVRPLVAELNALLQRVGQAFEAQQ-----HFVADAAHELRSPLAALK 258
Cdd:COG4191 82 LGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKlaalgELAAGIAHEINNPLAAIL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 259 --LQLVA--LQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQgtvqglqgmqgrhgaaaaAPADVDLREVVEQ 334
Cdd:COG4191 162 gnAELLRrrLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEE------------------EREPVDLNELIDE 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 335 ALADQAVAAQQHGLDMGLSESPQLRQsfaVAGDAQSLQMLVRNLLDNAVKYVPQG--GRVDVGWRSDAQGRALVVEDSGP 412
Cdd:COG4191 224 ALELLRPRLKARGIEVELDLPPDLPP---VLGDPGQLEQVLLNLLINAIDAMEEGegGRITISTRREGDYVVISVRDNGP 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2687004001 413 GIAESERELVLRRFVrgpsaaSAGQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:COG4191 301 GIPPEVLERIFEPFF------TTKPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGG 351
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
247-478 |
1.74e-21 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 96.60 E-value: 1.74e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 247 AHELRSPLAALKLQLvALQRAPDvAAHDEAVQRlsaGIDRATRLVEQLLTLARQEAQGTVQGLQgmqgrhgaaaaapaDV 326
Cdd:PRK10604 220 AHELRTPLVRLRYRL-EMSDNLS-AAESQALNR---DIGQLEALIEELLTYARLDRPQNELHLS--------------EP 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 327 DLREVVEQALADQAVAAQQHGLDMGLSESPQLrqsfaVAGDAQSLQMLVRNLLDNAVKYVpqGGRVDVGWRSDAQGRALV 406
Cdd:PRK10604 281 DLPAWLSTHLADIQAVTPEKTVRLDTPHQGDY-----GALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLI 353
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2687004001 407 VEDSGPGIAESERELVLRRFVRgpSAASAGQQAQGSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVQVIWP 478
Cdd:PRK10604 354 VEDDGPGIPPEERERVFEPFVR--LDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESE-LGGARFSFSWP 422
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
181-483 |
1.15e-20 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 94.23 E-value: 1.15e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 181 WWVVRSSLAPVQRVRR---ELATrrpQDLAPVPA-EGLPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRSPLAA 256
Cdd:PRK09470 184 LWLAWSLAKPARKLKNaadEVAQ---GNLRQHPElETGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTR 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 257 LKLQLVALQRApdvaaHDEA--VQRLSAGIDRATRLVEQLLTLARQEAQGTVQglqgmqgrhgaaaaapadvdlREVV-- 332
Cdd:PRK09470 261 LQLATALLRRR-----QGESkeLERIETEAQRLDSMINDLLVLSRNQQKNHLE---------------------RETFka 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 333 ----EQALADQAVAAQQHGLDMGLSESPQlrqSFAVAGDAQSLQMLVRNLLDNAVKYVPQggRVDVGWRSDAQGRALVVE 408
Cdd:PRK09470 315 nslwSEVLEDAKFEAEQMGKSLTVSAPPG---PWPINGNPNALASALENIVRNALRYSHT--KIEVAFSVDKDGLTITVD 389
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2687004001 409 DSGPGIAESERELVLRRFVRGPSAASagQQAQGSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVqVIWPPVSGR 483
Cdd:PRK09470 390 DDGPGVPEEEREQIFRPFYRVDEARD--RESGGTGLGLAIVENAIQQHRGWVKAEDSP-LGGLRL-TIWLPLYKR 460
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
367-478 |
4.03e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 85.59 E-value: 4.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSaaSAGQQAQGSGLGL 446
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVES--SRNRASGGSGLGL 78
|
90 100 110
....*....|....*....|....*....|..
gi 2687004001 447 AIVQTIAERHGARLLLDRSPtLGGLRVQVIWP 478
Cdd:cd16946 79 AICHNIALAHGGTISAEHSP-LGGLRLVLTLP 109
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
234-469 |
4.15e-20 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 91.45 E-value: 4.15e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 234 QAFEAQQHFVADAAHELRSPLAALK--LQLvaLQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAqgtvqglqg 311
Cdd:COG3852 130 EKLAAVGELAAGLAHEIRNPLTGIRgaAQL--LERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRP--------- 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 312 mqgrhgaaaAAPADVDLREVVEQALAdqaVAAQQHGLDMGLSE--SPQLRqsfAVAGDAQSLQMLVRNLLDNAVKYVPQG 389
Cdd:COG3852 199 ---------PEREPVNLHEVLERVLE---LLRAEAPKNIRIVRdyDPSLP---EVLGDPDQLIQVLLNLVRNAAEAMPEG 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 390 G------RVDVGWRSDAQGRALV----VEDSGPGIAESERELVLRRFVRGpsaasagqQAQGSGLGLAIVQTIAERHGAR 459
Cdd:COG3852 264 GtitirtRVERQVTLGGLRPRLYvrieVIDNGPGIPEEILDRIFEPFFTT--------KEKGTGLGLAIVQKIVEQHGGT 335
|
250
....*....|
gi 2687004001 460 LLLDRSPTLG 469
Cdd:COG3852 336 IEVESEPGKG 345
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-476 |
2.20e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 84.22 E-value: 2.20e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 344 QQHGLDMGLSESPQLRqsfaVAGDAQSLQMLVRNLLDNAVKYVpqGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVL 423
Cdd:cd16954 15 QRKGVSISLDISPELR----FPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIF 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2687004001 424 RRFVRgpsaasAGQQAQGSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVQVI 476
Cdd:cd16954 89 QRGQR------LDEQRPGQGLGLAIAKEIVEQYGGELSLSDSP-LGGARFEVV 134
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
181-476 |
5.04e-18 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 86.61 E-value: 5.04e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 181 WWvvrsSLAPVQ---RVRRELATRRPQDLAPVPaeglPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRSPLAAL 257
Cdd:PRK10815 213 WW----SLRPIEalaKQVRELEEGEREQLDPNP----PRELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 258 KLQLVALqRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLArqeaqgtvqglqGMQGRHgaaaaapaDVDLREVVE-QAL 336
Cdd:PRK10815 285 QSTLRSL-RSGKQMSVEQAEPIMLEQISRISQQIGYYLHRA------------SMRSEH--------NLLSRELHSvAPL 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 337 ADQAVAA-----QQHGLDMGLSESPQLrqSFAvaGDAQSLQMLVRNLLDNAVKYVPQggRVDVGWRSDAQGRALVVEDSG 411
Cdd:PRK10815 344 LDNLTSAlnkvyQRKGVNITLDISPEI--TFV--GEKNDFMEVMGNVLDNACKYCLE--FVEISARQTDEHLHIVVEDDG 417
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2687004001 412 PGIAESERELVLRRfvrgpsaasaGQQAQ----GSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVQVI 476
Cdd:PRK10815 418 PGIPESKRELIFDR----------GQRADtlrpGQGLGLSVAREITEQYEGKISAGDSP-LGGARMEVI 475
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-479 |
1.09e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 78.40 E-value: 1.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASagQQAQGSGLGLAIVQ 450
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERC--RNTGGTGLGLAIVK 78
|
90 100 110
....*....|....*....|....*....|
gi 2687004001 451 TIAERHGARLLLdrSPTLG-GLRVQVIWPP 479
Cdd:cd16952 79 HVMSRHDARLLI--ASELGkGSRFTCLFPS 106
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
183-456 |
2.00e-17 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 84.44 E-value: 2.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 183 VVRSSLAPVQRVRRELATRRPQDL-APVPAEGLPDEVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRSPLAALKLQL 261
Cdd:PRK09835 205 AVHKGHAPIRSVSRQIQNITSKDLdVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQT 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 262 -VALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQGTVQGLQGMqgrhgaaaaapadvDLREVVEQALADQA 340
Cdd:PRK09835 285 eIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKML--------------DLADEVGKVFDFFE 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 341 VAAQQHGLDMGLSESPQlrqsfAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERE 420
Cdd:PRK09835 351 AWAEERGVELRFVGDPC-----QVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLP 425
|
250 260 270
....*....|....*....|....*....|....*..
gi 2687004001 421 LVLRRFVR-GPSAASAGqqaQGSGLGLAIVQTIAERH 456
Cdd:PRK09835 426 RLFDRFYRvDPSRQRKG---EGSGIGLAIVKSIVVAH 459
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
367-478 |
7.72e-17 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 75.99 E-value: 7.72e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALV-VEDSGPGIAESERELVLRRFVRGpsAASAGQQAQGSGLG 445
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLtVSDSGPGIPPNLREEIFERFRQG--DGSSTRAHGGTGLG 78
|
90 100 110
....*....|....*....|....*....|...
gi 2687004001 446 LAIVQTIAERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:cd16925 79 LSIVKEFVELHGGTVTVSDAPG-GGALFQVELP 110
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-478 |
2.40e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 74.41 E-value: 2.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYvpQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGqqaqGSGLGLAIVQ 450
Cdd:cd16950 1 LKRVLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTS----GTGLGLAIVQ 74
|
90 100
....*....|....*....|....*...
gi 2687004001 451 TIAERHGARLLLdRSPTLGGLRVQVIWP 478
Cdd:cd16950 75 RISDAHGGSLTL-ANRAGGGLCARIELP 101
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
326-481 |
3.98e-16 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 80.34 E-value: 3.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 326 VDLREVVEQALadQAVAAQQHGLDMGLSESPQlrqsfAVAGDAQSLQMLVRNLLDNAVKYvpQGGRVDVGWRSDAQGRAL 405
Cdd:PRK09467 294 ADLNALLGEVI--AAESGYEREIETALQPGPI-----EVPMNPIAIKRALANLVVNAARY--GNGWIKVSSGTEGKRAWF 364
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2687004001 406 VVEDSGPGIAESERELVLRRFVRGPSAASagqqAQGSGLGLAIVQTIAERHGARLLLDRSPtLGGLRVQvIWPPVS 481
Cdd:PRK09467 365 QVEDDGPGIPPEQLKHLFQPFTRGDSARG----SSGTGLGLAIVKRIVDQHNGKVELGNSE-EGGLSAR-AWLPLT 434
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
372-469 |
9.13e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 72.91 E-value: 9.13e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 372 QMLVrNLLDNAVKYVPQGG-RVDVGWRSDAQGRALV---VEDSGPGIAESERELVLRRFVRGPSaaSAGQQAQGSGLGLA 447
Cdd:cd16922 3 QILL-NLLGNAIKFTEEGEvTLRVSLEEEEEDGVQLrfsVEDTGIGIPEEQQARLFEPFSQADS--STTRKYGGTGLGLA 79
|
90 100
....*....|....*....|..
gi 2687004001 448 IVQTIAERHGARLLLDRSPTLG 469
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQG 101
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-478 |
2.14e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 71.97 E-value: 2.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 377 NLLDNAVKYVPQggRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAgqQAQGSGLGLAIVQTIAERH 456
Cdd:cd16949 7 NVLRNALRYSPS--KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDR--ESGGTGLGLAIAERAIEQH 82
|
90 100
....*....|....*....|..
gi 2687004001 457 GARLLLDRSPTlGGLRVQVIWP 478
Cdd:cd16949 83 GGKIKASNRKP-GGLRVRIWLP 103
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-478 |
2.51e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 71.69 E-value: 2.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQggRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSaaSAGQQAQGSGLGLAIVQ 450
Cdd:cd16939 1 MARALDNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDP--SRDRATGGFGLGLAIVH 76
|
90 100
....*....|....*....|....*...
gi 2687004001 451 TIAERHGARLLLDRSPtLGGLRVQVIWP 478
Cdd:cd16939 77 RVALWHGGHVECDDSE-LGGACFRLTWP 103
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-469 |
3.42e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 68.51 E-value: 3.42e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQG--GRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVR--GPSAAsagqqaQGSGLGL 446
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRlhSREEY------EGTGVGL 74
|
90 100
....*....|....*....|...
gi 2687004001 447 AIVQTIAERHGARLLLDRSPTLG 469
Cdd:cd16921 75 AIVRKIIERHGGRIWLESEPGEG 97
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
241-483 |
4.60e-14 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 74.05 E-value: 4.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 241 HFVADAAHELRSPLAALK-LQLVALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQeaqgtvqglqgmqgrhgaA 319
Cdd:PRK10364 239 HLAAGVAHEIRNPLSSIKgLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKP------------------T 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 320 AAAPADVDLREVVEQALADQAVAAQQHGLDMGLSESPQLRqsfAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSD 399
Cdd:PRK10364 301 HLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLP---EIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASES 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 400 AQGRALVVEDSGPGIAESERELVLRRFVRgpsaasagQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLGGlrVQVIWPP 479
Cdd:PRK10364 378 GAGVKISVTDSGKGIAADQLEAIFTPYFT--------TKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGA--TFTLWLP 447
|
....
gi 2687004001 480 VSGR 483
Cdd:PRK10364 448 VNIT 451
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
242-469 |
8.01e-14 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 73.85 E-value: 8.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 242 FVADAAHELRSPLAALKLQLVALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQGTVQglqgmqgrhgaaaa 321
Cdd:PRK11360 393 LVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQP-------------- 458
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 322 apadVDLREVVEQALADQAVAAQQHGLDMGLSESPQLRqsfAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQ 401
Cdd:PRK11360 459 ----VSLNALVEEVLQLFQTAGVQARVDFETELDNELP---PIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSD 531
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2687004001 402 GRALV-VEDSGPGIAESERELVLRRFVRgpsaasagQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:PRK11360 532 GQVAVsIEDNGCGIDPELLKKIFDPFFT--------TKAKGTGLGLALSQRIINAHGGDIEVESEPGVG 592
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
248-478 |
1.70e-13 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 73.15 E-value: 1.70e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 248 HELRSPLAALKLQ--LVALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQGTVQGLQGMQgrhgaaaaapad 325
Cdd:PRK10490 673 HDLRTPLTVLFGQaeILTLDLASEGSPHARQASEIRQQVLNTTRLVNNLLDMARIQSGGFNLRKEWLT------------ 740
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 326 vdLREVVEQALADQAVAAQQHGLDMGLSESPQLrqsfaVAGDAQSLQMLVRNLLDNAVKYVpqGGRVDVGWRSDAQGRAL 405
Cdd:PRK10490 741 --LEEVVGSALQMLEPGLSGHPINLSLPEPLTL-----IHVDGPLFERVLINLLENAVKYA--GAQAEIGIDAHVEGERL 811
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2687004001 406 VVE--DSGPGIAESERELVLRRFVRGPSAASagqqAQGSGLGLAIVQTIAERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:PRK10490 812 QLDvwDNGPGIPPGQEQLIFDKFARGNKESA----IPGVGLGLAICRAIVEVHGGTIWAENRPE-GGACFRVTLP 881
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
367-466 |
4.02e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 65.56 E-value: 4.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASagqQAQGSGLGL 446
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHS---GQKSTGLGL 77
|
90 100
....*....|....*....|
gi 2687004001 447 AIVQTIAERHGARLLLDRSP 466
Cdd:cd16945 78 AFVQEVAQLHGGRITLRNRP 97
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
336-479 |
6.54e-13 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 71.21 E-value: 6.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 336 LADQAVA-----AQQHGLDMGLSESPQLRQSFAVagDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQgRALVVEDS 410
Cdd:PRK15347 476 LLDQAMLtiqgpAQSKSLTLRTFVGAHVPLYLHL--DSLRLRQILVNLLGNAVKFTETGGIRLRVKRHEQQ-LCFTVEDT 552
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2687004001 411 GPGIAESERELVLRRFVRgpsaasAGQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLGG-----LRVQVIWPP 479
Cdd:PRK15347 553 GCGIDIQQQQQIFTPFYQ------ADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGScfslvLPLNEYAPP 620
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
217-469 |
3.12e-12 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 69.38 E-value: 3.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 217 EVRPLVAELNALLQRVGQAFEAQQHFVADAAHELRSPLAALK--LQLVAlqrapdvaahdeavqrlSAGIDRATRLveQL 294
Cdd:PRK09959 690 ETRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMgfLELLS-----------------GSGLSKEQRV--EA 750
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 295 LTLArqeaQGTVQGLQGMQGR--------HGAAAAAPADVDLREVVEQALAD-QAVAAQQhglDMGLSESPQLRQSFAVA 365
Cdd:PRK09959 751 ISLA----YATGQSLLGLIGEildvdkieSGNYQLQPQWVDIPTLVQNTCHSfGAIAASK---SIALSCSSTFPDHYLVK 823
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 366 GDAQSLQMLVRNLLDNAVKYVPQGG-RVDVGWRSDAQGRALV---VEDSGPGIAESERELVLRRFvrgpSAASAGQQAQG 441
Cdd:PRK09959 824 IDPQAFKQVLSNLLSNALKFTTEGAvKITTSLGHIDDNHAVIkmtIMDSGSGLSQEEQQQLFKRY----SQTSAGRQQTG 899
|
250 260
....*....|....*....|....*...
gi 2687004001 442 SGLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:PRK09959 900 SGLGLMICKELIKNMQGDLSLESHPGIG 927
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
366-466 |
3.29e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 63.30 E-value: 3.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 366 GDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRR-FVRGPSAASAgqqAQGSGL 444
Cdd:cd16947 16 ANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERlYTLEDSRNSA---KQGNGL 92
|
90 100
....*....|....*....|..
gi 2687004001 445 GLAIVQTIAERHGARLLLDRSP 466
Cdd:cd16947 93 GLTITKRLAESMGGSIYVNSKP 114
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
244-469 |
3.96e-12 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 68.22 E-value: 3.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 244 ADAAHELRSPLAALK--LQLvaLQRAPDVaaHDEAVQRLSAGIDRATRLVEQLLTLAR-QEAQGTVQGLQGMqgrhgaaa 320
Cdd:COG5805 292 AGIAHEIRNPLTSIKgfLQL--LQPGIED--KEEYFDIMLSELDRIESIISEFLALAKpQAVNKEKENINEL-------- 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 321 aapadvdLREVVEQALADqavaAQQHGLDMGLSEspqLRQSFAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDA 400
Cdd:COG5805 360 -------IQDVVTLLETE----AILHNIQIRLEL---LDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEED 425
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2687004001 401 QGRALVVEDSGPGIAESerelVLRRFvrgpsaasaGQ-----QAQGSGLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:COG5805 426 NSVIIRVIDEGIGIPEE----RLKKL---------GEpffttKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKG 486
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
214-469 |
5.09e-12 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 67.28 E-value: 5.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 214 LPDEVRPLVAELNALLQRVgqafEAQQHFVADAAHELRSPLAALKLQLVALQRA---PDVAAHDEAVQRLSAGIDRATRL 290
Cdd:PRK09303 130 LSDELFVLRQENETLLEQL----KFKDRVLAMLAHDLRTPLTAASLALETLELGqidEDTELKPALIEQLQDQARRQLEE 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 291 VEQLLTLARQEAQGTVQGLQGMQGRhgaaaaapadVDLR----EVVEQaLADQAVAAQQHGLDMGLSESPqlrqsfAVAG 366
Cdd:PRK09303 206 IERLITDLLEVGRTRWEALRFNPQK----------LDLGslcqEVILE-LEKRWLAKSLEIQTDIPSDLP------SVYA 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNAVKYVPQGGRVDVGW--RSDaQGRALVVEDSGPGIAESERELVLRRFVRGPSAasagQQAQGSGL 444
Cdd:PRK09303 269 DQERIRQVLLNLLDNAIKYTPEGGTITLSMlhRTT-QKVQVSICDTGPGIPEEEQERIFEDRVRLPRD----EGTEGYGI 343
|
250 260
....*....|....*....|....*
gi 2687004001 445 GLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:PRK09303 344 GLSVCRRIVRVHYGQIWVDSEPGQG 368
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
375-469 |
2.85e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 59.99 E-value: 2.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 375 VRNLLDNAVKYV----PQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVlrrFVRGPSAASAGqqaqGSGLGLAIVQ 450
Cdd:cd16915 5 VGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKV---FERGVSTKGQG----ERGIGLALVR 77
|
90
....*....|....*....
gi 2687004001 451 TIAERHGARLLLDRSPTLG 469
Cdd:cd16915 78 QSVERLGGSITVESEPGGG 96
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
367-475 |
1.10e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 58.63 E-value: 1.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGQQaqgSGLGL 446
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGH---YGMGL 77
|
90 100
....*....|....*....|....*....
gi 2687004001 447 AIVQTIAERHGARLLLDRSPTlGGLRVQV 475
Cdd:cd16975 78 YIAKNLVEKHGGSLIIENSQK-GGAEVTV 105
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
238-303 |
1.14e-10 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 57.22 E-value: 1.14e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2687004001 238 AQQHFVADAAHELRSPLAALKLQLVALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQ 303
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
237-299 |
1.16e-10 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 57.22 E-value: 1.16e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2687004001 237 EAQQHFVADAAHELRSPLAALKLQL-VALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLAR 299
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALeLLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
238-303 |
1.91e-10 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 56.42 E-value: 1.91e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2687004001 238 AQQHFVADAAHELRSPLAALKLQLVALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQ 303
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
343-469 |
3.48e-10 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 61.79 E-value: 3.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 343 AQQHGLDMGLSESPQLRQSFAVAGDaqslqmLVR---NLLDNAVKYV----PQGGRVDVGWRSDAQGRALVVEDSGPGIA 415
Cdd:COG3290 257 ARERGIDLTIDIDSDLPDLPLSDTD------LVTilgNLLDNAIEAVeklpEEERRVELSIRDDGDELVIEVEDSGPGIP 330
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 2687004001 416 ESERELVlrrFVRGPSaasaGQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:COG3290 331 EELLEKI---FERGFS----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEG 377
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-460 |
7.95e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 55.86 E-value: 7.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRGPSAASAGqqaqGSGLGLAIVQ 450
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTE----GAGLGLSIAK 76
|
90
....*....|
gi 2687004001 451 TIAERHGARL 460
Cdd:cd16923 77 AIIELHGGSA 86
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-470 |
2.09e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 54.71 E-value: 2.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQGGR----VDVGWRSDAQGR-ALVVEDSGPGIAESERELVLRRFVRgpsaasagQQAQGSGLG 445
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCerreLTIRTSPADDRAvTISVKDTGPGIAEEVAGQLFDPFYT--------TKSEGLGMG 72
|
90 100
....*....|....*....|....*
gi 2687004001 446 LAIVQTIAERHGARllLDRSPTLGG 470
Cdd:cd16920 73 LSICRSIIEAHGGR--LSVESPAGG 95
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-457 |
2.60e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 54.89 E-value: 2.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVP-QGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRF-VRGPSAASAGQQaqgSGLGLAI 448
Cdd:cd16953 1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFyTERPANEAFGQH---SGLGLSI 77
|
....*....
gi 2687004001 449 VQTIAERHG 457
Cdd:cd16953 78 SRQIIEAHG 86
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
367-457 |
6.24e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 53.44 E-value: 6.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESErelVLRRFVRGPSAASAGQQAQGSGLGL 446
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEED---LPRVFDKGFTGENGRNFQESTGMGL 78
|
90
....*....|.
gi 2687004001 447 AIVQTIAERHG 457
Cdd:cd16948 79 YLVKKLCDKLG 89
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
367-478 |
1.24e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 52.54 E-value: 1.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNA------VKYVPQGGRVDVgwRSDAQGR-ALVVEDSGPGIAESERELVLRRFVRgpsaasagQQA 439
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaiegRPSDVGEVRIRV--EADQDGRiVLIVCDNGKGFPREMRHRATEPYVT--------TRP 70
|
90 100 110
....*....|....*....|....*....|....*....
gi 2687004001 440 QGSGLGLAIVQTIAERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:cd16944 71 KGTGLGLAIVKKIMEEHGGRISLSNREA-GGACIRIILP 108
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-478 |
2.37e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 51.65 E-value: 2.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 368 AQSLQMLVrNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVrgpsaaSAGQQAQGSGLGLA 447
Cdd:cd16943 2 SQLNQVLL-NLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF------TTKPVGEGTGLGLS 74
|
90 100 110
....*....|....*....|....*....|.
gi 2687004001 448 IVQTIAERHGARLLLdRSPTLGGLRVQVIWP 478
Cdd:cd16943 75 LSYRIIQKHGGTIRV-ASVPGGGTRFTIILP 104
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-462 |
1.15e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 49.76 E-value: 1.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVP--QGGRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVrgpsaaSAGQQAQGSGLGLAI 448
Cdd:cd16976 1 IQQVLMNLLQNALDAMGkvENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF------TTKPVGKGTGLGLSI 74
|
90
....*....|....
gi 2687004001 449 VQTIAERHGARLLL 462
Cdd:cd16976 75 SYGIVEEHGGRLSV 88
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
229-460 |
2.28e-07 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 53.05 E-value: 2.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 229 LQRVGQafeaqqhFVADAAHELRSPLAALK--LQLVALqrapdvAAHDEavQRLSAGI-----DRATRLVEQLLTLARQE 301
Cdd:COG5809 267 LSVVGE-------LAAGIAHEIRNPLTSLKgfIQLLKD------TIDEE--QKTYLDImlselDRIESIISEFLVLAKPQ 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 302 AqgtvqglqgMQGRHgaaaaapadVDLREVVEQALA---DQAV-------AAQQHGLDMGLSESPQLRQSFAvagdaqsl 371
Cdd:COG5809 332 A---------IKYEP---------KDLNTLIEEVIPllqPQALlknvqieLELEDDIPDILGDENQLKQVFI-------- 385
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 372 qmlvrNLLDNAVKYVPQGGRVDVGWRSDAQGRALV-VEDSGPGIAESerelVLRRFvrgpsaasaGQ-----QAQGSGLG 445
Cdd:COG5809 386 -----NLLKNAIEAMPEGGNITIETKAEDDDKVVIsVTDEGCGIPEE----RLKKL---------GEpfyttKEKGTGLG 447
|
250
....*....|....*
gi 2687004001 446 LAIVQTIAERHGARL 460
Cdd:COG5809 448 LMVSYKIIEEHGGKI 462
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
212-469 |
5.03e-07 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 52.60 E-value: 5.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 212 EGLPDEVRPLVAELNALLQRVGQAF-------EAQQHFVADAAHELRSPLAAL--KLQLVALQraPDVAAHDEAVQRLSA 282
Cdd:PRK11466 410 EQLAAQVKARTAELQELVIEHRQARaeaekasQAKSAFLAAMSHEIRTPLYGIlgTAQLLADN--PALNAQRDDLRAITD 487
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 283 GIDRATRLVEQLLTLARQEAQGTVQGLQgmqgrhgaaaaaPADVDLREVVEQALADQAVAAQQHGLDMGLSESPQLRQsf 362
Cdd:PRK11466 488 SGESLLTILNDILDYSAIEAGGKNVSVS------------DEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLPT-- 553
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 363 AVAGDAQSLQMLVRNLLDNAVKYVPQGgRVDVGWRSDAQGRALVVEDSGPGIAESERELVLRRFVRgpsaasAGQQAQGS 442
Cdd:PRK11466 554 ALMGDPRRIRQVITNLLSNALRFTDEG-SIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQ------VSGKRGGT 626
|
250 260
....*....|....*....|....*..
gi 2687004001 443 GLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:PRK11466 627 GLGLTISSRLAQAMGGELSATSTPEVG 653
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-466 |
5.83e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 47.78 E-value: 5.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQGG-------RVDVGWRSDAQGRALV----VEDSGPGIAESERELVLRRFVRGpsaasagqQA 439
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGgeiilrtRTQRQVTLGHPRHRLAlrvsVIDNGPGIPPDLQDTIFYPMVSG--------RE 72
|
90 100
....*....|....*....|....*..
gi 2687004001 440 QGSGLGLAIVQTIAERHGARLLLDRSP 466
Cdd:cd16918 73 NGTGLGLAIAQNIVSQHGGVIECDSQP 99
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
247-462 |
2.04e-06 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 50.46 E-value: 2.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 247 AHELRSPLAALKLQLVALQRApdvaAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQGTVQGLQGMQgrhgaaaaapaDV 326
Cdd:COG4192 441 AHELNQPLNAMSMYLFSAKKA----LEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQ-----------PV 505
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 327 DLREVVEQALADQAVAAQQHGLDMGLSESPQlrqsfaVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALV 406
Cdd:COG4192 506 DLRQVIEQAWELVESRAKPQQITLHIPDDLM------VQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVA 579
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 2687004001 407 VEDSGPGIAESERelVLRRFVRGPSAasagqqaqGSGLGLAIVQTIAERHGARLLL 462
Cdd:COG4192 580 ISDNGNGWPLVDK--LFTPFTTTKEV--------GLGLGLSICRSIMQQFGGDLYL 625
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
343-453 |
3.27e-06 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 49.55 E-value: 3.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 343 AQQHGLDMGLSESPQLRQsfAVAGDAQSLQMLVRNLLDNAVKYVPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERELV 422
Cdd:PRK11091 373 AEQKGLRFDLEPLLPLPH--KVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYEEGDMLTFEVEDSGIGIPEDELDKI 450
|
90 100 110
....*....|....*....|....*....|.
gi 2687004001 423 LRRFVRGPSAAsAGQQAQGSGLGLAIVQTIA 453
Cdd:PRK11091 451 FAMYYQVKDSH-GGKPATGTGIGLAVSKRLA 480
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
327-457 |
3.81e-06 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 49.46 E-value: 3.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 327 DLREVVEQALADQAVAAQQHGLDMGLSESPQLRQSfaVAGDAQSLQMLVRNLLDNAVKYVPQGG-RVDVGWRSDAQGRAL 405
Cdd:PRK11107 367 SLRETLDEVVTLLAHSAHEKGLELTLNIDPDVPDN--VIGDPLRLQQIITNLVGNAIKFTESGNiDILVELRALSNTKVQ 444
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 2687004001 406 V---VEDSGPGIAESERELVLRRFvrGPSAASAGQQAQGSGLGLAIVQTIAERHG 457
Cdd:PRK11107 445 LevqIRDTGIGISERQQSQLFQAF--RQADASISRRHGGTGLGLVITQKLVNEMG 497
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
8-478 |
5.21e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 45.67 E-value: 5.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 8 LVSSLVARARSRLPGALGTRLLMFLGAAIVLTALLQGLLAYRNALLQTDTLFDYQMQQTAFALRAGLPVDARGRPQGTPP 87
Cdd:COG3920 1 LLLALLLLLLLALAALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 88 EDENHEFIVQVWTNEGLRIFESALGAALPQMAVLGFADVPARGTVYRVFSLQTRSQVIQVAQDMRVRRTLARDAAWQSLL 167
Cdd:COG3920 81 LLALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 168 PIALLAPVLALAVWWVVRSSLAPVQRVRRELATRRPQDLAPVPAEGLPDEVRPLVAELNALLQRVGQAFEAQQHFVADAA 247
Cdd:COG3920 161 LLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 248 HELRSPLAALKLQLVALQRAPDVAAHDEAVQRLSAGIDRATRLVEQLLTLARQEAQ--------------GTVQGLQGMQ 313
Cdd:COG3920 241 LERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKElllrelhhrvknnlQVVSSLLRLQ 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 314 GRHGA--------------------------AAAAPADVDLREVVEQALADQAVAAQQHGLDMGLS-ESPQLRqsfavAG 366
Cdd:COG3920 321 ARRADdpearealeesqnriqalalvhellyQSEDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDgPDVELP-----AD 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 367 DAQSLQMLVRNLLDNAVKY---VPQGGRVDVGWRSDAQGRALVVEDSGPGIAESERElvlrrfvrgpsaasagqqAQGSG 443
Cdd:COG3920 396 AAVPLGLILNELVTNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDVDP------------------PARKG 457
|
490 500 510
....*....|....*....|....*....|....*
gi 2687004001 444 LGLAIVQTIAERHGARLLLDRSPtlgGLRVQVIWP 478
Cdd:COG3920 458 LGLRLIRALVRQLGGTLELDRPE---GTRVRITFP 489
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
181-478 |
7.32e-05 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 45.01 E-value: 7.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 181 WWVVRSSLAPVQRVRRELATRRPQDLAPVPAEGlPDEVRPLVAELNALLQRVGQAFEAQQhfvadaahELRspLAALKLQ 260
Cdd:COG2972 175 YLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSG-NDEIGILARSFNEMVERIKELIEEVY--------ELE--LEKKEAE 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 261 LVALQRA--PdvaaHD-----EAVQRL--SAGIDRATRLVEQLLTLARQeaqgTVQGLQGMqgrhgaaaaapadVDLREv 331
Cdd:COG2972 244 LKALQAQinP----HFlfntlNSIRWLaeLEDPEEAEEMLEALSKLLRY----SLSKGDEL-------------VTLEE- 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 332 vEQALADQAVAAQQhgLDMGlsesPQLRQSFAVAGDAQSLQMLVR---NLLDNAVKY----VPQGGRVDVGWRSDAQGRA 404
Cdd:COG2972 302 -ELELIKSYLEIQK--LRFG----DRLEVEIEIDEELLDLLIPKLilqPLVENAIEHgiepKEGGGTIRISIRKEGDRLV 374
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2687004001 405 LVVEDSGPGIAESERELVLRRFvrgpsaasaGQQAQGSGLGLAIVQT-IAERHGARLLLD-RSPTLGGLRVQVIWP 478
Cdd:COG2972 375 ITVEDNGVGMPEEKLEKLLEEL---------SSKGEGRGIGLRNVRErLKLYYGEEYGLEiESEPGEGTTVTIRIP 441
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
371-469 |
6.51e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 39.29 E-value: 6.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKYVPQGGRVDVGWRSD-------------AQGR--ALVVEDSGPGIAESERELVLRRFVrgpsaaSA 435
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETSNQrvdadyalnyrdlIPGNyvCLEVSDTGSGMPAEVLRRAFEPFF------TT 74
|
90 100 110
....*....|....*....|....*....|....
gi 2687004001 436 GQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLG 469
Cdd:cd16919 75 KEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVG 108
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
363-448 |
7.41e-04 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 42.27 E-value: 7.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 363 AVAGDAQSLQMLVRNLLDNAVKYVPQGGRV-DVGWRSDAqgRALVVEDSGPGIAESErelVLRRFVRGPSAASAGQQA-Q 440
Cdd:PRK10841 555 ALNGDPMRLQQVISNLLSNAIKFTDTGCIVlHVRVDGDY--LSFRVRDTGVGIPAKE---VVRLFDPFFQVGTGVQRNfQ 629
|
....*...
gi 2687004001 441 GSGLGLAI 448
Cdd:PRK10841 630 GTGLGLAI 637
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
217-482 |
1.85e-03 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 40.82 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 217 EVRPLVAELNALLQRVGQA--FEAQQHFVADAAHELRSPLAAL----KLQLVALQRAPDVAAHdeaVQRLSAGIDRATRL 290
Cdd:PRK13837 426 ERRRLETERDALERRLEHArrLEAVGTLASGIAHNFNNILGAIlgyaEMALNKLARHSRAARY---IDEIISAGARARLI 502
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 291 VEQLLTLARQEAQGTVQglqgmqgrhgaaaaapadVDLREVVEQALADQAVAAQQH-GLDMGLSESPQLrqsfaVAGDAQ 369
Cdd:PRK13837 503 IDQILAFGRKGERNTKP------------------FDLSELVTEIAPLLRVSLPPGvELDFDQDQEPAV-----VEGNPA 559
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 370 SLQMLVRNLLDNAVKYVPQGGRVDV--------GWRSDAQGRA-------LVVEDSGPGIAESERELVLRRFVRgpsaas 434
Cdd:PRK13837 560 ELQQVLMNLCSNAAQAMDGAGRVDIslsraklrAPKVLSHGVLppgryvlLRVSDTGAGIDEAVLPHIFEPFFT------ 633
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2687004001 435 agQQAQGSGLGLAIVQTIAERHGARllLDRSPTLG-GLRVQVIWPPVSG 482
Cdd:PRK13837 634 --TRAGGTGLGLATVHGIVSAHAGY--IDVQSTVGrGTRFDVYLPPSSK 678
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
277-471 |
3.66e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 39.82 E-value: 3.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 277 VQRLSAGIDRATRLVEQLLTLaRQEA---QGTVQGLQGMQ----GRHGAAAAAPADVDLREVVEQALADQAVA------- 342
Cdd:PRK15053 325 ISTLNAQLTQIKQYVESLRTL-RHEHlnwMSTLNGLLQMKeydrVLEMVQGESQAQQQLIDSLREAFADRQVAgllfgkv 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 343 --AQQHGLDMGLSESPQLRQsFAVAGDAQSLQMLVRNLLDNAVK---YVPQGGRVDVGWRSDaQGRALVVE--DSGPGIA 415
Cdd:PRK15053 404 qrARELGLKMVIVPGSQLSQ-LPPGLDSTEFAAIVGNLLDNAFEaslRSDEGNKIVELFLSD-EGDDVVIEvaDQGCGVP 481
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 2687004001 416 ESERELVlrrFVRGPSAASagQQAQGSGLGLAIVQTIAERHGARLLLDRSPTLGGL 471
Cdd:PRK15053 482 ESLRDKI---FEQGVSTRA--DEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTL 532
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
371-477 |
8.53e-03 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 35.71 E-value: 8.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 371 LQMLVRNLLDNAVKY---VPQGGRVDVGWRSDAQGRALVVEDSGPGIAeserelvlRRFVRGPSAAsagqqAQGSGLGLA 447
Cdd:cd16936 1 VELAVSEAVTNAVRHayrHDGPGPVRLELDLDPDRLRVEVTDSGPGFD--------PLRPADPDAG-----LREGGRGLA 67
|
90 100 110
....*....|....*....|....*....|
gi 2687004001 448 IVQTIAERHGARllldrsPTLGGLRVQVIW 477
Cdd:cd16936 68 LIRALMDEVGYR------RTPGGKTVWLEL 91
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
273-478 |
8.92e-03 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 38.06 E-value: 8.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 273 HDEAVQRLSA---GIDRATRLVEQLLTLARQEAQGTVQGLQGMQGR-----HGAAAAAPADVDLREVVEQALADqavAAQ 344
Cdd:COG4585 62 HDGVGQSLSAiklQLEAARRLLDADPEAAREELEEIRELAREALAElrrlvRGLRPPALDDLGLAAALEELAER---LLR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2687004001 345 QHGLDMGLSESPQLRQSFAVAGDAqsLQMLVRNLLDNAVKYVpQGGRVDVGWRSDAQGRALVVEDSGPGIAEserelvlr 424
Cdd:COG4585 139 AAGIRVELDVDGDPDRLPPEVELA--LYRIVQEALTNALKHA-GATRVTVTLEVDDGELTLTVRDDGVGFDP-------- 207
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 2687004001 425 rfvrgpsaasagQQAQGSGLGLAIVQTIAERHGARLLLDRSPTlGGLRVQVIWP 478
Cdd:COG4585 208 ------------EAAPGGGLGLRGMRERAEALGGTLTIGSAPG-GGTRVRATLP 248
|
|
|