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Conserved domains on  [gi|2691702349|ref|WP_335426911|]
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GNAT family N-acetyltransferase, partial [Bacillus sp. JJ269]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10003213)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 140-243 8.93e-09

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


:

Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 52.69  E-value: 8.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691702349 140 VQAFYNQISNLDICNsENLKLFLGLYEGEVVTVGSLICSKDSIG-IYDIATKEGMRGRGFGSTMFNFLLQEAQKFKNTYC 218
Cdd:COG1246    11 VPAILELIRPYALEE-EIGEFWVAEEDGEIVGCAALHPLDEDLAeLRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRL 89

                          90       100
                  ....*....|....*....|....*
gi 2691702349 219 VLQASHDGINIYKKSGFQAIGKMTV 243
Cdd:COG1246    90 FLLTTSAAIHFYEKLGFEEIDKEDL 114
 
Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 140-243 8.93e-09

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 52.69  E-value: 8.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691702349 140 VQAFYNQISNLDICNsENLKLFLGLYEGEVVTVGSLICSKDSIG-IYDIATKEGMRGRGFGSTMFNFLLQEAQKFKNTYC 218
Cdd:COG1246    11 VPAILELIRPYALEE-EIGEFWVAEEDGEIVGCAALHPLDEDLAeLRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRL 89

                          90       100
                  ....*....|....*....|....*
gi 2691702349 219 VLQASHDGINIYKKSGFQAIGKMTV 243
Cdd:COG1246    90 FLLTTSAAIHFYEKLGFEEIDKEDL 114
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 134-243 7.09e-07

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 47.27  E-value: 7.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691702349 134 SEEGIHVqaFYNQISNLDI---CNSENLKLFLGLYEGEVVTVGSLicsKDSIGIYDIATKEGMRGRGFGSTMFNFLLQEA 210
Cdd:pfam13673   6 SEEGIET--FYEFISPEALrerIDQGEYFFFVAFEGGQIVGVIAL---RDRGHISLLFVDPDYQGQGIGKALLEAVEDYA 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2691702349 211 --QKFKNTYCVLQASHDGINIYKKSGFQAIGKMTV 243
Cdd:pfam13673  81 ekDGIKLSELTVNASPYAVPFYEKLGFRATGPEQE 115
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 160-220 2.26e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 38.41  E-value: 2.26e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2691702349 160 LFLGLYEGEVVTVGSLI---CSKDSIGIYDIATKEGMRGRGFGSTMFNFLLQEAQKFKNTYCVL 220
Cdd:cd04301     1 FLVAEDDGEIVGFASLSpdgSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
 
Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 140-243 8.93e-09

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 52.69  E-value: 8.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691702349 140 VQAFYNQISNLDICNsENLKLFLGLYEGEVVTVGSLICSKDSIG-IYDIATKEGMRGRGFGSTMFNFLLQEAQKFKNTYC 218
Cdd:COG1246    11 VPAILELIRPYALEE-EIGEFWVAEEDGEIVGCAALHPLDEDLAeLRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRL 89

                          90       100
                  ....*....|....*....|....*
gi 2691702349 219 VLQASHDGINIYKKSGFQAIGKMTV 243
Cdd:COG1246    90 FLLTTSAAIHFYEKLGFEEIDKEDL 114
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
161-239 2.98e-08

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 50.95  E-value: 2.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691702349 161 FLGLYEGEVVTVGSLICSKD---SIGiyDIATKEGMRGRGFGSTMFNFLLQEAQKFKNTYCVLQASHDGINIYKKSGFQA 237
Cdd:COG2153    37 LLAYDDGELVATARLLPPGDgeaKIG--RVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQAHAVGFYEKLGFVP 114


                  ..
gi 2691702349 238 IG 239
Cdd:COG2153   115 VG 116
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 134-243 7.09e-07

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 47.27  E-value: 7.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691702349 134 SEEGIHVqaFYNQISNLDI---CNSENLKLFLGLYEGEVVTVGSLicsKDSIGIYDIATKEGMRGRGFGSTMFNFLLQEA 210
Cdd:pfam13673   6 SEEGIET--FYEFISPEALrerIDQGEYFFFVAFEGGQIVGVIAL---RDRGHISLLFVDPDYQGQGIGKALLEAVEDYA 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2691702349 211 --QKFKNTYCVLQASHDGINIYKKSGFQAIGKMTV 243
Cdd:pfam13673  81 ekDGIKLSELTVNASPYAVPFYEKLGFRATGPEQE 115
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 160-243 2.85e-06

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 45.43  E-value: 2.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691702349 160 LFLGLYEGEVVTVGSL-ICSKDSIGIYDIATKEGMRGRGFGSTMFNFLLQEAQKFKNTYCVLQAS---HDGINIYKKSGF 235
Cdd:COG0454    36 FIAVDDKGEPIGFAGLrRLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLdgnPAAIRFYERLGF 115


                  ....*...
gi 2691702349 236 QAIGKMTV 243
Cdd:COG0454   116 KEIERYVA 123
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 184-239 3.68e-06

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 44.26  E-value: 3.68e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2691702349 184 IYDIATKEGMRGRGFGSTMFNFLLQEAQKFKNTYCVLQASHD---GINIYKKSGFQAIG 239
Cdd:COG0456    16 IEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDneaAIALYEKLGFEEVG 74
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
161-243 3.86e-06

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 45.46  E-value: 3.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691702349 161 FLGLYEGEVV-----TVGSLICSKDSIGIYDIATKEGMRGRGFGSTMFNFLLQEAQKFKNTYCVLQASHDGINIYKKSGF 235
Cdd:COG3153    42 LVAEDDGEIVghvalSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLPFYERFGF 121


                  ....*...
gi 2691702349 236 QAIGKMTV 243
Cdd:COG3153   122 RPAGELGL 129
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
168-244 5.62e-06

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 43.36  E-value: 5.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691702349 168 EVVTVGSL-ICSKDSIGIYDIATKEGMRGRGFGSTMFNFLLQEAQKFKNTYCVLQ---ASHDGINIYKKSGFQAIGKMTV 243
Cdd:COG3393     1 ELVAMAGVrAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYvdaDNPAARRLYERLGFRPVGEYAT 80


                  .
gi 2691702349 244 L 244
Cdd:COG3393    81 V 81
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 156-236 2.13e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 42.06  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691702349 156 ENLKLFLGLYEGEVVTVGSLICSKDS--IGIYDIATKEGMRGRGFGSTMFNFLLQEAQKFKNTYCVLQASHDGINIYKKS 233
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEgaLAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAAAFYEKL 80


                  ...
gi 2691702349 234 GFQ 236
Cdd:pfam13508  81 GFE 83
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 150-235 2.69e-05

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 42.50  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691702349 150 LDICNSENLKLFLGLYEGEVVtvGSLICSKDS-----IGIYDIATKEGMRGRGFGSTMFNFLLQEAQKFKNTYCVLQASH 224
Cdd:pfam00583  25 EDWDEDASEGFFVAEEDGELV--GFASLSIIDdeppvGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAA 102

                          90
                  ....*....|....
gi 2691702349 225 DG---INIYKKSGF 235
Cdd:pfam00583 103 DNlaaIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 160-220 2.26e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 38.41  E-value: 2.26e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2691702349 160 LFLGLYEGEVVTVGSLI---CSKDSIGIYDIATKEGMRGRGFGSTMFNFLLQEAQKFKNTYCVL 220
Cdd:cd04301     1 FLVAEDDGEIVGFASLSpdgSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
180-241 8.96e-03

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 35.74  E-value: 8.96e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2691702349 180 DSIGIYDIATKEGMRGRGFGSTMFNFLLQEAQKfkNTYCVLQAS-----HDGINIYKKSGFQAIGKM 241
Cdd:COG1247    79 RGTAEESIYVDPDARGRGIGRALLEALIERARA--RGYRRLVAVvladnEASIALYEKLGFEEVGTL 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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