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Conserved domains on  [gi|2691738377|ref|WP_335448161|]
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Cna B-type domain-containing protein, partial [Bacillus toyonensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 1-51 1.49e-19

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


:

Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 77.29  E-value: 1.49e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2691738377   1 TKEVSAAGEWKYAFTDLAAYDAEGNAYKYEVKEQPVDGYKSEV---HGYDITNT 51
Cdd:pfam05738  35 TKELTAANNWTYTFTDLPKYDENGKEITYTVEEDAVPGYTTTVdakDGFTITNT 88
SCO1860_LAETG super family cl49495
SCO1860 family LAETG-anchored protein; Members of this poorly characterized family, including ...
 41-148 2.29e-06

SCO1860 family LAETG-anchored protein; Members of this poorly characterized family, including SCO1860 from Streptomyces coelicolor, are surface proteins whose C-terminus contains a variant type sortase recognition and cleavage sorting signal. The sorting signal motif, LAETG, is compatible with processing by a SrtE family sortase enzyme.


The actual alignment was detected with superfamily member NF041527:

Pssm-ID: 469412 [Multi-domain]  Cd Length: 305  Bit Score: 45.50  E-value: 2.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691738377  41 SEVHGyDITNTKDPSTDPKDPSTDPKDPSTDPKDPSTDPKDPSTDPKDPSTDPKDPSIDsknpptqensktsvwLPKTGG 120
Cdd:NF041527  214 AEVEG-TVTLAEATCETPAAPGEPPAEPSEPEEAPAEEATGTGPDVKPPGEAAADPGEN---------------LAETGG 277

                          90       100       110
                  ....*....|....*....|....*....|
gi 2691738377 121 TSmdMISYIAG--MLLLALGGFVFVRQRMR 148
Cdd:NF041527  278 SS--ATPYIAGgaALLLAAGGGALALARRR 305
 
Name Accession Description Interval E-value
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 1-51 1.49e-19

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 77.29  E-value: 1.49e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2691738377   1 TKEVSAAGEWKYAFTDLAAYDAEGNAYKYEVKEQPVDGYKSEV---HGYDITNT 51
Cdd:pfam05738  35 TKELTAANNWTYTFTDLPKYDENGKEITYTVEEDAVPGYTTTVdakDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 1-52 1.92e-16

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 69.63  E-value: 1.92e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2691738377   1 TKEVSAAGEWKYAFTDLAAYDAEGNAYKYEVKEQPVDGYKSEV----HGYDITNTK 52
Cdd:cd00222    37 TVTLTASNDWTYTFTNLPKYDENGKEITYTVKEVPVPGYTTTVtgddGGFTITNTH 92
SCO1860_LAETG NF041527
SCO1860 family LAETG-anchored protein; Members of this poorly characterized family, including ...
 41-148 2.29e-06

SCO1860 family LAETG-anchored protein; Members of this poorly characterized family, including SCO1860 from Streptomyces coelicolor, are surface proteins whose C-terminus contains a variant type sortase recognition and cleavage sorting signal. The sorting signal motif, LAETG, is compatible with processing by a SrtE family sortase enzyme.


Pssm-ID: 469412 [Multi-domain]  Cd Length: 305  Bit Score: 45.50  E-value: 2.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691738377  41 SEVHGyDITNTKDPSTDPKDPSTDPKDPSTDPKDPSTDPKDPSTDPKDPSTDPKDPSIDsknpptqensktsvwLPKTGG 120
Cdd:NF041527  214 AEVEG-TVTLAEATCETPAAPGEPPAEPSEPEEAPAEEATGTGPDVKPPGEAAADPGEN---------------LAETGG 277

                          90       100       110
                  ....*....|....*....|....*....|
gi 2691738377 121 TSmdMISYIAG--MLLLALGGFVFVRQRMR 148
Cdd:NF041527  278 SS--ATPYIAGgaALLLAAGGGALALARRR 305
LPXTG_anchor TIGR01167
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region ...
 115-148 2.33e-05

LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other]


Pssm-ID: 273478 [Multi-domain]  Cd Length: 34  Bit Score: 39.38  E-value: 2.33e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2691738377 115 LPKTGGTSMDMISyIAGMLLLALGGFVFVRQRMR 148
Cdd:TIGR01167   2 LPKTGESGNSLLL-LLGLLLLGLGGLLLRKRKKK 34
PRK09418 PRK09418
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
50-146 7.48e-05

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 236504 [Multi-domain]  Cd Length: 780  Bit Score: 41.62  E-value: 7.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691738377  50 NTKDPSTDPKDPSTDPKDPSTDPKDPSTDPKDPSTDPKDPSTDPKDPSIDSKNPPTQENSKTSVW-----LPKTGGTSMD 124
Cdd:PRK09418  677 NGENPTTPPTGEGNNGENPTTPPTGEGNNGGNPTTPSTDEGNNAGSGQTTTDNQNSKETTTVSENkeerdLPKTGTSVAS 756

                          90       100
                  ....*....|....*....|..
gi 2691738377 125 MISyiAGMLLLALGGFVFVRQR 146
Cdd:PRK09418  757 TIG--AGLAFIGAGFLLLFRRK 776
Gram_pos_anchor pfam00746
LPXTG cell wall anchor motif;
106-146 5.61e-03

LPXTG cell wall anchor motif;


Pssm-ID: 366278 [Multi-domain]  Cd Length: 43  Bit Score: 32.90  E-value: 5.61e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2691738377 106 QENSKTSVwLPKTGGTSmdMISY-IAGMLLLALGGFVFVRQR 146
Cdd:pfam00746   1 AKKSKKKT-LPKTGENS--NIFLtAAGLLALLGGLLLLVKRR 39
 
Name Accession Description Interval E-value
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 1-51 1.49e-19

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 77.29  E-value: 1.49e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2691738377   1 TKEVSAAGEWKYAFTDLAAYDAEGNAYKYEVKEQPVDGYKSEV---HGYDITNT 51
Cdd:pfam05738  35 TKELTAANNWTYTFTDLPKYDENGKEITYTVEEDAVPGYTTTVdakDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 1-52 1.92e-16

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 69.63  E-value: 1.92e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2691738377   1 TKEVSAAGEWKYAFTDLAAYDAEGNAYKYEVKEQPVDGYKSEV----HGYDITNTK 52
Cdd:cd00222    37 TVTLTASNDWTYTFTNLPKYDENGKEITYTVKEVPVPGYTTTVtgddGGFTITNTH 92
SCO1860_LAETG NF041527
SCO1860 family LAETG-anchored protein; Members of this poorly characterized family, including ...
 41-148 2.29e-06

SCO1860 family LAETG-anchored protein; Members of this poorly characterized family, including SCO1860 from Streptomyces coelicolor, are surface proteins whose C-terminus contains a variant type sortase recognition and cleavage sorting signal. The sorting signal motif, LAETG, is compatible with processing by a SrtE family sortase enzyme.


Pssm-ID: 469412 [Multi-domain]  Cd Length: 305  Bit Score: 45.50  E-value: 2.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691738377  41 SEVHGyDITNTKDPSTDPKDPSTDPKDPSTDPKDPSTDPKDPSTDPKDPSTDPKDPSIDsknpptqensktsvwLPKTGG 120
Cdd:NF041527  214 AEVEG-TVTLAEATCETPAAPGEPPAEPSEPEEAPAEEATGTGPDVKPPGEAAADPGEN---------------LAETGG 277

                          90       100       110
                  ....*....|....*....|....*....|
gi 2691738377 121 TSmdMISYIAG--MLLLALGGFVFVRQRMR 148
Cdd:NF041527  278 SS--ATPYIAGgaALLLAAGGGALALARRR 305
LPXTG_anchor TIGR01167
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region ...
 115-148 2.33e-05

LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other]


Pssm-ID: 273478 [Multi-domain]  Cd Length: 34  Bit Score: 39.38  E-value: 2.33e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2691738377 115 LPKTGGTSMDMISyIAGMLLLALGGFVFVRQRMR 148
Cdd:TIGR01167   2 LPKTGESGNSLLL-LLGLLLLGLGGLLLRKRKKK 34
PRK09418 PRK09418
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
50-146 7.48e-05

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 236504 [Multi-domain]  Cd Length: 780  Bit Score: 41.62  E-value: 7.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691738377  50 NTKDPSTDPKDPSTDPKDPSTDPKDPSTDPKDPSTDPKDPSTDPKDPSIDSKNPPTQENSKTSVW-----LPKTGGTSMD 124
Cdd:PRK09418  677 NGENPTTPPTGEGNNGENPTTPPTGEGNNGGNPTTPSTDEGNNAGSGQTTTDNQNSKETTTVSENkeerdLPKTGTSVAS 756

                          90       100
                  ....*....|....*....|..
gi 2691738377 125 MISyiAGMLLLALGGFVFVRQR 146
Cdd:PRK09418  757 TIG--AGLAFIGAGFLLLFRRK 776
Gram_pos_anchor pfam00746
LPXTG cell wall anchor motif;
106-146 5.61e-03

LPXTG cell wall anchor motif;


Pssm-ID: 366278 [Multi-domain]  Cd Length: 43  Bit Score: 32.90  E-value: 5.61e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2691738377 106 QENSKTSVwLPKTGGTSmdMISY-IAGMLLLALGGFVFVRQR 146
Cdd:pfam00746   1 AKKSKKKT-LPKTGENS--NIFLtAAGLLALLGGLLLLVKRR 39
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 51-107 8.48e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 35.56  E-value: 8.48e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691738377  51 TKDPSTDPKDPSTDPKDPSTD---PKDPSTDPKDPSTDPKDPSTDPKDPSIDSKNPPTQE 107
Cdd:PRK14950  375 APSPVRPTPAPSTRPKAAAAAnipPKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRA 434
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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