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Conserved domains on  [gi|2691746092|ref|WP_335452366|]
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excalibur calcium-binding domain-containing protein, partial [Bacillus thuringiensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Excalibur pfam05901
Excalibur calcium-binding domain; Extracellular Ca2+-dependent nuclease YokF from Bacillus ...
 219-254 6.07e-19

Excalibur calcium-binding domain; Extracellular Ca2+-dependent nuclease YokF from Bacillus subtilis and several other surface-exposed proteins from diverse bacteria are encoded in the genomes in two paralogous forms that differ by a ~45 amino acid fragment, which comprises a novel conserved domain. Sequence analysis of this domain revealed a conserved DxDxDGxxCE motif, which is strikingly similar to the Ca2+-binding loop of the calmodulin-like EF-hand domains, suggesting an evolutionary relationship between them. Functions of many of the other proteins in which the novel domain, named Excalibur (extracellular calcium-binding region), is found, as well as a structural model of its conserved motif are consistent with the notion that the Excalibur domain binds calcium. This domain is but one more example of the diversity of structural contexts surrounding the EF-hand-like calcium-binding loop in bacteria. This loop is thus more widespread than hitherto recognized and the evolution of EF-hand-like domains is probably more complex than previously appreciated.


:

Pssm-ID: 428664  Cd Length: 36  Bit Score: 77.12  E-value: 6.07e-19
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2691746092 219 YKNCAAVRAAGKAPLHKGQPGYDSHLDRDGDGVACE 254
Cdd:pfam05901   1 YKNCTEARSAGEAPIYRGAPGYRSKLDRDGDGIACE 36
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 151-194 1.74e-07

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


:

Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 49.27  E-value: 1.74e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2691746092 151 QKQEDEKRQAEEQARKQEEQKRQADEQARKQHEEQKRQADEQAR 194
Cdd:pfam05672  36 EKEEEERLRKEELRRRAEEERARREEEARRLEEERRREEEERQR 79
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 91-194 1.97e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


:

Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 45.22  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092  91 KKQFIITAVLFVIFVALLVISA----------------------PSSEKTTATSTKVASNNEEQKNSEQKKELEKKEADE 148
Cdd:TIGR02794   1 RRAFLLSLLLHILLLGLLILGSlyhsvkpepgggaeiiqavlvdPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEEA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2691746092 149 KTQKQEDEKRQAEEQARKQEEQKRQADEQARKQHEEQKRQADEQAR 194
Cdd:TIGR02794  81 EKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKA 126
COG4652 super family cl47356
Uncharacterized conserved protein, DUF1430 domain [Function unknown];
1-115 8.79e-05

Uncharacterized conserved protein, DUF1430 domain [Function unknown];


The actual alignment was detected with superfamily member COG4652:

Pssm-ID: 443690 [Multi-domain]  Cd Length: 583  Bit Score: 43.16  E-value: 8.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092   1 ILSNIGAALFS--IAFILLILCIISFFKKNGKAKQYGCPTVILFMISIILITTgttksehpvveffsTLSFILFIFFLVI 78
Cdd:COG4652   118 IKRIIRLAILLalISLLLSILILWLFYNGLAGFGLFFLLSLLLLSVLLLLIIL--------------LISLIALLLIRRI 183

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2691746092  79 AILSVIKKTGVAKKQFIITAVLFVIFVALLVISAPSS 115
Cdd:COG4652   184 SIVSAIKGKLPTKGLLALSYVVKIIALILVIFTLITS 220
 
Name Accession Description Interval E-value
Excalibur pfam05901
Excalibur calcium-binding domain; Extracellular Ca2+-dependent nuclease YokF from Bacillus ...
 219-254 6.07e-19

Excalibur calcium-binding domain; Extracellular Ca2+-dependent nuclease YokF from Bacillus subtilis and several other surface-exposed proteins from diverse bacteria are encoded in the genomes in two paralogous forms that differ by a ~45 amino acid fragment, which comprises a novel conserved domain. Sequence analysis of this domain revealed a conserved DxDxDGxxCE motif, which is strikingly similar to the Ca2+-binding loop of the calmodulin-like EF-hand domains, suggesting an evolutionary relationship between them. Functions of many of the other proteins in which the novel domain, named Excalibur (extracellular calcium-binding region), is found, as well as a structural model of its conserved motif are consistent with the notion that the Excalibur domain binds calcium. This domain is but one more example of the diversity of structural contexts surrounding the EF-hand-like calcium-binding loop in bacteria. This loop is thus more widespread than hitherto recognized and the evolution of EF-hand-like domains is probably more complex than previously appreciated.


Pssm-ID: 428664  Cd Length: 36  Bit Score: 77.12  E-value: 6.07e-19
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2691746092 219 YKNCAAVRAAGKAPLHKGQPGYDSHLDRDGDGVACE 254
Cdd:pfam05901   1 YKNCTEARSAGEAPIYRGAPGYRSKLDRDGDGIACE 36
Excalibur smart00894
Excalibur calcium-binding domain; Extracellular Ca2+-dependent nuclease YokF from Bacillus ...
 218-254 4.01e-18

Excalibur calcium-binding domain; Extracellular Ca2+-dependent nuclease YokF from Bacillus subtilis and several other surface-exposed proteins from diverse bacteria are encoded in the genomes in two paralogous forms that differ by a ~45 amino acid fragment, which comprises a novel conserved domain. Sequence analysis of this domain revealed a conserved DxDxDGxxCE motif, which is strikingly similar to the Ca2+-binding loop of the calmodulin-like EF-hand domains, suggesting an evolutionary relationship between them. Functions of many of the other proteins in which the novel domain, named Excalibur (extracellular calcium-binding region), is found, as well as a structural model of its conserved motif are consistent with the notion that the Excalibur domain binds calcium. This domain is but one more example of the diversity of structural contexts surrounding the EF-hand-like calcium-binding loop in bacteria. This loop is thus more widespread than hitherto recognised and the evolution of EF-hand-like domains is probably more complex than previously appreciated.


Pssm-ID: 214891 [Multi-domain]  Cd Length: 37  Bit Score: 75.00  E-value: 4.01e-18
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2691746092  218 YYKNCAAVRAAGKAPLHKGQPGYDSHLDRDGDGVACE 254
Cdd:smart00894   1 YYKNCKEARAAGAAPIYQGDPGYGPHLDRDGDGVACE 37
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 151-194 1.74e-07

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 49.27  E-value: 1.74e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2691746092 151 QKQEDEKRQAEEQARKQEEQKRQADEQARKQHEEQKRQADEQAR 194
Cdd:pfam05672  36 EKEEEERLRKEELRRRAEEERARREEEARRLEEERRREEEERQR 79
PTZ00121 PTZ00121
MAEBL; Provisional
 151-191 1.29e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 1.29e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2691746092  151 QKQEDEKRQAEEQARKQEEQKRQAdEQARKQHEEQKRQADE 191
Cdd:PTZ00121  1681 KKAEEDEKKAAEALKKEAEEAKKA-EELKKKEAEEKKKAEE 1720
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 91-194 1.97e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 45.22  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092  91 KKQFIITAVLFVIFVALLVISA----------------------PSSEKTTATSTKVASNNEEQKNSEQKKELEKKEADE 148
Cdd:TIGR02794   1 RRAFLLSLLLHILLLGLLILGSlyhsvkpepgggaeiiqavlvdPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEEA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2691746092 149 KTQKQEDEKRQAEEQARKQEEQKRQADEQARKQHEEQKRQADEQAR 194
Cdd:TIGR02794  81 EKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKA 126
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 91-192 3.36e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 44.41  E-value: 3.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092  91 KKQFIITAVLFVIFVALLVISApSSEKTTA----------------TSTKVAS-NNEEQKNSEQKKELEKKEADEKTQKQ 153
Cdd:PRK09510   12 KRAIIISVVLHIILFALLIWSS-FDENIEAsggggggsvidavmvdPGAVVEQyNRQQQQQKSAKRAEEQRKKKEQQQAE 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2691746092 154 EDEKRQAEEQAR-KQEEQKRQADEQARKQHEEQKRQADEQ 192
Cdd:PRK09510   91 ELQQKQAAEQERlKQLEKERLAAQEQKKQAEEAAKQAALK 130
COG4652 COG4652
Uncharacterized conserved protein, DUF1430 domain [Function unknown];
1-115 8.79e-05

Uncharacterized conserved protein, DUF1430 domain [Function unknown];


Pssm-ID: 443690 [Multi-domain]  Cd Length: 583  Bit Score: 43.16  E-value: 8.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092   1 ILSNIGAALFS--IAFILLILCIISFFKKNGKAKQYGCPTVILFMISIILITTgttksehpvveffsTLSFILFIFFLVI 78
Cdd:COG4652   118 IKRIIRLAILLalISLLLSILILWLFYNGLAGFGLFFLLSLLLLSVLLLLIIL--------------LISLIALLLIRRI 183

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2691746092  79 AILSVIKKTGVAKKQFIITAVLFVIFVALLVISAPSS 115
Cdd:COG4652   184 SIVSAIKGKLPTKGLLALSYVVKIIALILVIFTLITS 220
glyco_rpt_poly TIGR04370
oligosaccharide repeat unit polymerase; Members of this subfamily of highly hydrophobic ...
 2-111 3.68e-04

oligosaccharide repeat unit polymerase; Members of this subfamily of highly hydrophobic proteins, with few highly conserved residues, all may act to polymerize the oligosaccharide repeat units of surface polysaccharides, including O-antigen in Gram-negative bacteria such as Leptospira (assign gene symbol wzy) and capsular polysaccharide in Gram-positive bacteria such as Streptococcus. O-antigen biosynthesis enzymes produce a repeat unit, usually an oligosaccharide, which itself is polymerized. O-antigen polymerase, usually designated Wzy. This family bears homology to the O-antigen ligase WaaL, but known examples of WaaL fall outside the bounds defined here. This model is much broader than pfam14296. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 275163 [Multi-domain]  Cd Length: 392  Bit Score: 41.38  E-value: 3.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092   2 LSNIGAALFSIAFILLILCIISFFKKNGKAKQYgcptVILFMISIILITTGTTKSehpvveffstlSFILFIFFLVIAIL 81
Cdd:TIGR04370 135 FLSGLIILLYILIILLLLLFLLLLLKKKRKKLL----LLLILLALLISLLTGSRT-----------GLILLILSLLFIYY 199

                          90       100       110
                  ....*....|....*....|....*....|
gi 2691746092  82 SVIKKTGVAKKQFIITAVLFVIFVALLVIS 111
Cdd:TIGR04370 200 LFYKKKSLKKILKILLLLILVFILILLLFI 229
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 8-119 9.83e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 39.92  E-value: 9.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092   8 ALFSIAFILLILCII--SFFKKNG--------KAKQYGCPTVILFMISIIL----------ITTGTTKSEHPVVEFFSTL 67
Cdd:cd06179   228 APLVIGGVLLIAFGLyeWKGTKDGllpprllfRGRNFALILIVAFVEGMIFyslnifwpqqISLLFTTDPLKAGLYQLPF 307

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2691746092  68 SFILFIFFLVIAILsvIKKTGVAKKQFIITAVLFVIFVALLVISAPSSEKTT 119
Cdd:cd06179   308 GLGTLFGAILAGLL--LTKIKHIKWQLVAGFVLFTAFLALLALITPDNKALA 357
ABC2_membrane_3 pfam12698
ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter ...
 5-112 2.72e-03

ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter family pfam01061.


Pssm-ID: 463674 [Multi-domain]  Cd Length: 345  Bit Score: 38.53  E-value: 2.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092   5 IGAALFSIAFILLILCIISFFKKNGKAKQYGCPtVILFMISIILITTGTTKSEHPVVEFFStlsfILFIFFLVIAILSVI 84
Cdd:pfam12698 243 LLFLLYGLAYIALGYLLGSLFKNSEDAQSIIGI-VILLLSGFFGGLFPLEDPPSFLQWIFS----IIPFFSPIDGLLRLI 317

                          90       100
                  ....*....|....*....|....*....
gi 2691746092  85 kkTGVAKKQFIIT-AVLFVIFVALLVISA 112
Cdd:pfam12698 318 --YGDSLWEIAPSlIILLLFAVVLLLLAL 344
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 151-194 3.83e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 37.90  E-value: 3.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2691746092 151 QKQEDEKRQAEEQARKQEEQKRQADEQA--RKQHEEQKRQADEQAR 194
Cdd:TIGR02794 112 KQAEEKQKQAEEAKAKQAAEAKAKAEAEaeRKAKEEAAKQAEEEAK 157
 
Name Accession Description Interval E-value
Excalibur pfam05901
Excalibur calcium-binding domain; Extracellular Ca2+-dependent nuclease YokF from Bacillus ...
 219-254 6.07e-19

Excalibur calcium-binding domain; Extracellular Ca2+-dependent nuclease YokF from Bacillus subtilis and several other surface-exposed proteins from diverse bacteria are encoded in the genomes in two paralogous forms that differ by a ~45 amino acid fragment, which comprises a novel conserved domain. Sequence analysis of this domain revealed a conserved DxDxDGxxCE motif, which is strikingly similar to the Ca2+-binding loop of the calmodulin-like EF-hand domains, suggesting an evolutionary relationship between them. Functions of many of the other proteins in which the novel domain, named Excalibur (extracellular calcium-binding region), is found, as well as a structural model of its conserved motif are consistent with the notion that the Excalibur domain binds calcium. This domain is but one more example of the diversity of structural contexts surrounding the EF-hand-like calcium-binding loop in bacteria. This loop is thus more widespread than hitherto recognized and the evolution of EF-hand-like domains is probably more complex than previously appreciated.


Pssm-ID: 428664  Cd Length: 36  Bit Score: 77.12  E-value: 6.07e-19
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2691746092 219 YKNCAAVRAAGKAPLHKGQPGYDSHLDRDGDGVACE 254
Cdd:pfam05901   1 YKNCTEARSAGEAPIYRGAPGYRSKLDRDGDGIACE 36
Excalibur smart00894
Excalibur calcium-binding domain; Extracellular Ca2+-dependent nuclease YokF from Bacillus ...
 218-254 4.01e-18

Excalibur calcium-binding domain; Extracellular Ca2+-dependent nuclease YokF from Bacillus subtilis and several other surface-exposed proteins from diverse bacteria are encoded in the genomes in two paralogous forms that differ by a ~45 amino acid fragment, which comprises a novel conserved domain. Sequence analysis of this domain revealed a conserved DxDxDGxxCE motif, which is strikingly similar to the Ca2+-binding loop of the calmodulin-like EF-hand domains, suggesting an evolutionary relationship between them. Functions of many of the other proteins in which the novel domain, named Excalibur (extracellular calcium-binding region), is found, as well as a structural model of its conserved motif are consistent with the notion that the Excalibur domain binds calcium. This domain is but one more example of the diversity of structural contexts surrounding the EF-hand-like calcium-binding loop in bacteria. This loop is thus more widespread than hitherto recognised and the evolution of EF-hand-like domains is probably more complex than previously appreciated.


Pssm-ID: 214891 [Multi-domain]  Cd Length: 37  Bit Score: 75.00  E-value: 4.01e-18
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2691746092  218 YYKNCAAVRAAGKAPLHKGQPGYDSHLDRDGDGVACE 254
Cdd:smart00894   1 YYKNCKEARAAGAAPIYQGDPGYGPHLDRDGDGVACE 37
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 151-194 1.74e-07

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 49.27  E-value: 1.74e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2691746092 151 QKQEDEKRQAEEQARKQEEQKRQADEQARKQHEEQKRQADEQAR 194
Cdd:pfam05672  36 EKEEEERLRKEELRRRAEEERARREEEARRLEEERRREEEERQR 79
PTZ00121 PTZ00121
MAEBL; Provisional
 151-191 1.29e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 1.29e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2691746092  151 QKQEDEKRQAEEQARKQEEQKRQAdEQARKQHEEQKRQADE 191
Cdd:PTZ00121  1681 KKAEEDEKKAAEALKKEAEEAKKA-EELKKKEAEEKKKAEE 1720
PTZ00121 PTZ00121
MAEBL; Provisional
 116-191 2.39e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.60  E-value: 2.39e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2691746092  116 EKTTATSTKVASNNEEQKNSEQKKELEKKEADEKTQKQEDEKRQAEEQARKQEEQKRQADEQARKQHEEQKRQADE 191
Cdd:PTZ00121  1673 DKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEE 1748
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 152-193 6.11e-06

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 45.03  E-value: 6.11e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2691746092 152 KQEDEKRQAEEQARKQEEQKRQAdEQARKQHEEQKRQADEQA 193
Cdd:pfam05672  45 KEELRRRAEEERARREEEARRLE-EERRREEEERQRKAEEEA 85
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 151-194 1.13e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 45.95  E-value: 1.13e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2691746092 151 QKQEDEKRQAEEQARKQEEQKRQADEQARKQHEEQKRQADEQAR 194
Cdd:PRK09510  111 LAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKAKAEAEAK 154
PTZ00121 PTZ00121
MAEBL; Provisional
 111-194 1.22e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 1.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092  111 SAPSSEKTTATSTKVASNNEEQKNSEQKKELEKKEADEKTQKQEDEKRQAEEQARKQEEQKRQADE-----QARKQHEEQ 185
Cdd:PTZ00121  1344 AAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADElkkaaAAKKKADEA 1423


                   ....*....
gi 2691746092  186 KRQADEQAR 194
Cdd:PTZ00121  1424 KKKAEEKKK 1432
PTZ00121 PTZ00121
MAEBL; Provisional
 151-191 1.24e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 1.24e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2691746092  151 QKQEDEKRQAEEqARKQEEQKRQADEQARKQhEEQKRQADE 191
Cdd:PTZ00121  1668 KKAEEDKKKAEE-AKKAEEDEKKAAEALKKE-AEEAKKAEE 1706
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 91-194 1.97e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 45.22  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092  91 KKQFIITAVLFVIFVALLVISA----------------------PSSEKTTATSTKVASNNEEQKNSEQKKELEKKEADE 148
Cdd:TIGR02794   1 RRAFLLSLLLHILLLGLLILGSlyhsvkpepgggaeiiqavlvdPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEEA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2691746092 149 KTQKQEDEKRQAEEQARKQEEQKRQADEQARKQHEEQKRQADEQAR 194
Cdd:TIGR02794  81 EKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKA 126
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 151-194 2.06e-05

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 45.33  E-value: 2.06e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2691746092 151 QKQEDEKRQAEEQARKQEEQKRQADEQARKQHEEQKRQADEQAR 194
Cdd:pfam15709 394 QRLEEERQRQEEEERKQRLQLQAAQERARQQQEEFRRKLQELQR 437
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 151-194 3.02e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 44.41  E-value: 3.02e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2691746092 151 QKQEDEKRQAEEQARKQ--EEQKRQADEQARKQHEEQKRQADEQAR 194
Cdd:PRK09510   80 QRKKKEQQQAEELQQKQaaEQERLKQLEKERLAAQEQKKQAEEAAK 125
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 91-192 3.36e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 44.41  E-value: 3.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092  91 KKQFIITAVLFVIFVALLVISApSSEKTTA----------------TSTKVAS-NNEEQKNSEQKKELEKKEADEKTQKQ 153
Cdd:PRK09510   12 KRAIIISVVLHIILFALLIWSS-FDENIEAsggggggsvidavmvdPGAVVEQyNRQQQQQKSAKRAEEQRKKKEQQQAE 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2691746092 154 EDEKRQAEEQAR-KQEEQKRQADEQARKQHEEQKRQADEQ 192
Cdd:PRK09510   91 ELQQKQAAEQERlKQLEKERLAAQEQKKQAEEAAKQAALK 130
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 67-193 4.00e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 44.07  E-value: 4.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092  67 LSFILFIFFLVIAILSVIKKTGVAKKQFIITAVLFVIFVALLVISAPSSEKTTATSTKVASNNEEQKNSEQKKELEKKEA 146
Cdd:TIGR02794  10 LHILLLGLLILGSLYHSVKPEPGGGAEIIQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEEAEKQRAAEQA 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2691746092 147 DEKTQKQ----EDEKRQAEEQARKQEEQKRQADEQARKQHEEQKRQADEQA 193
Cdd:TIGR02794  90 RQKELEQraaaEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAEA 140
PTZ00121 PTZ00121
MAEBL; Provisional
 114-194 5.50e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 5.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092  114 SSEKTTATSTKVAsnnEEQKNSEQKKELEKKEADEKTQKQEDEKRQAEEQARKQEEQKRQADEqARKQHEEQKRqADEQA 193
Cdd:PTZ00121  1274 AEEARKADELKKA---EEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADA-AKKKAEEAKK-AAEAA 1348


                   .
gi 2691746092  194 R 194
Cdd:PTZ00121  1349 K 1349
PTZ00121 PTZ00121
MAEBL; Provisional
 112-194 7.14e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 7.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092  112 APSSEKTTATSTKVASNNEEQKNSEQKKELEKKEADEKTQ---KQEDEKRQAEEQARKQEEQKRQAdEQARKQHEEQKRQ 188
Cdd:PTZ00121  1612 AKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEElkkAEEENKIKAAEEAKKAEEDKKKA-EEAKKAEEDEKKA 1690


                   ....*.
gi 2691746092  189 ADEQAR 194
Cdd:PTZ00121  1691 AEALKK 1696
PTZ00121 PTZ00121
MAEBL; Provisional
 151-194 8.54e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 8.54e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2691746092  151 QKQEDEKRQAEEQARKQEEQKRQAdEQARKQHEEQKRQADEQAR 194
Cdd:PTZ00121  1695 KKEAEEAKKAEELKKKEAEEKKKA-EELKKAEEENKIKAEEAKK 1737
COG4652 COG4652
Uncharacterized conserved protein, DUF1430 domain [Function unknown];
1-115 8.79e-05

Uncharacterized conserved protein, DUF1430 domain [Function unknown];


Pssm-ID: 443690 [Multi-domain]  Cd Length: 583  Bit Score: 43.16  E-value: 8.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092   1 ILSNIGAALFS--IAFILLILCIISFFKKNGKAKQYGCPTVILFMISIILITTgttksehpvveffsTLSFILFIFFLVI 78
Cdd:COG4652   118 IKRIIRLAILLalISLLLSILILWLFYNGLAGFGLFFLLSLLLLSVLLLLIIL--------------LISLIALLLIRRI 183

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2691746092  79 AILSVIKKTGVAKKQFIITAVLFVIFVALLVISAPSS 115
Cdd:COG4652   184 SIVSAIKGKLPTKGLLALSYVVKIIALILVIFTLITS 220
PTZ00121 PTZ00121
MAEBL; Provisional
 151-191 9.17e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 9.17e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2691746092  151 QKQEDEKRQAEEQARKQEEQKRQADEqARKQhEEQKRQADE 191
Cdd:PTZ00121  1476 KKKAEEAKKADEAKKKAEEAKKKADE-AKKA-AEAKKKADE 1514
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 151-194 1.27e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 42.63  E-value: 1.27e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2691746092 151 QKQEdekrqAEEQARKQ-EEQKRQADEQARKQHEEQKRQADEQAR 194
Cdd:pfam15709 482 QKQE-----AEEKARLEaEERRQKEEEAARLALEEAMKQAQEQAR 521
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 151-192 2.18e-04

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 40.41  E-value: 2.18e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2691746092 151 QKQEDEKRQAEEQARKQEEQKRQADEQARKQHEEQKRQADEQ 192
Cdd:pfam05672  57 ARREEEARRLEEERRREEEERQRKAEEEAEEREQREQEEQER 98
glyco_rpt_poly TIGR04370
oligosaccharide repeat unit polymerase; Members of this subfamily of highly hydrophobic ...
 2-111 3.68e-04

oligosaccharide repeat unit polymerase; Members of this subfamily of highly hydrophobic proteins, with few highly conserved residues, all may act to polymerize the oligosaccharide repeat units of surface polysaccharides, including O-antigen in Gram-negative bacteria such as Leptospira (assign gene symbol wzy) and capsular polysaccharide in Gram-positive bacteria such as Streptococcus. O-antigen biosynthesis enzymes produce a repeat unit, usually an oligosaccharide, which itself is polymerized. O-antigen polymerase, usually designated Wzy. This family bears homology to the O-antigen ligase WaaL, but known examples of WaaL fall outside the bounds defined here. This model is much broader than pfam14296. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 275163 [Multi-domain]  Cd Length: 392  Bit Score: 41.38  E-value: 3.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092   2 LSNIGAALFSIAFILLILCIISFFKKNGKAKQYgcptVILFMISIILITTGTTKSehpvveffstlSFILFIFFLVIAIL 81
Cdd:TIGR04370 135 FLSGLIILLYILIILLLLLFLLLLLKKKRKKLL----LLLILLALLISLLTGSRT-----------GLILLILSLLFIYY 199

                          90       100       110
                  ....*....|....*....|....*....|
gi 2691746092  82 SVIKKTGVAKKQFIITAVLFVIFVALLVIS 111
Cdd:TIGR04370 200 LFYKKKSLKKILKILLLLILVFILILLLFI 229
PTZ00121 PTZ00121
MAEBL; Provisional
 114-191 5.15e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 5.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092  114 SSEKTTATSTKVASNNEEQKNSEQKKELEKKEADEKTQKQEDEKRQAEEqARKQEEQKRQADEQARKQHE---------- 183
Cdd:PTZ00121  1387 AEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADE-AKKKAEEAKKADEAKKKAEEakkaeeakkk 1465


                   ....*....
gi 2691746092  184 -EQKRQADE 191
Cdd:PTZ00121  1466 aEEAKKADE 1474
PTZ00121 PTZ00121
MAEBL; Provisional
 114-191 6.05e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 6.05e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2691746092  114 SSEKTTATSTKVASNNEEQKNSEQKKELEKKEADEKTQKQEdEKRQAEEqARKQEEQKRQADEqARKQHEEQKRQADE 191
Cdd:PTZ00121  1427 AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAE-EAKKADE-AKKKAEEAKKADE-AKKKAEEAKKKADE 1501
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 151-196 7.69e-04

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 38.87  E-value: 7.69e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2691746092 151 QKQEDEKRQAEEQAR-KQEEQKRQADEQARKQHEEQKRQADEQARKQ 196
Cdd:pfam05672  20 RRQAREQREREEQERlEKEEEERLRKEELRRRAEEERARREEEARRL 66
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 8-119 9.83e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 39.92  E-value: 9.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092   8 ALFSIAFILLILCII--SFFKKNG--------KAKQYGCPTVILFMISIIL----------ITTGTTKSEHPVVEFFSTL 67
Cdd:cd06179   228 APLVIGGVLLIAFGLyeWKGTKDGllpprllfRGRNFALILIVAFVEGMIFyslnifwpqqISLLFTTDPLKAGLYQLPF 307

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2691746092  68 SFILFIFFLVIAILsvIKKTGVAKKQFIITAVLFVIFVALLVISAPSSEKTT 119
Cdd:cd06179   308 GLGTLFGAILAGLL--LTKIKHIKWQLVAGFVLFTAFLALLALITPDNKALA 357
PTZ00121 PTZ00121
MAEBL; Provisional
 151-191 1.06e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 1.06e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2691746092  151 QKQEDEKRQAEEqARKQEEQKRQAD-----EQARKQHE----EQKRQADE 191
Cdd:PTZ00121  1490 KKAEEAKKKADE-AKKAAEAKKKADeakkaEEAKKADEakkaEEAKKADE 1538
PTZ00121 PTZ00121
MAEBL; Provisional
 124-191 1.24e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 1.24e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2691746092  124 KVASNNEEQKNSEQKKELEKKEADEKTQKQEdEKRQAEEqARKQEEQKRQADEqARKQHEEQKRQADE 191
Cdd:PTZ00121  1269 QAAIKAEEARKADELKKAEEKKKADEAKKAE-EKKKADE-AKKKAEEAKKADE-AKKKAEEAKKKADA 1333
NosY COG1277
ABC-type transport system involved in multi-copper enzyme maturation, permease component ...
 39-112 1.49e-03

ABC-type transport system involved in multi-copper enzyme maturation, permease component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440888 [Multi-domain]  Cd Length: 201  Bit Score: 38.64  E-value: 1.49e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2691746092  39 VILFMISIILITTGTTKSEHPVVEFFSTLSFILFIFFLVIAIL--SVIKKTGVAkkqFIITAVLFVIFVALLVISA 112
Cdd:COG1277   114 TFLLALLLGLLLFGSPPPDLGAILGFYLGLLLLGLAFLAIGLFisALTRNQIVA---AILAIALWLLLVILLAWIV 186
PLN02316 PLN02316
synthase/transferase
 154-194 1.55e-03

synthase/transferase


Pssm-ID: 215180 [Multi-domain]  Cd Length: 1036  Bit Score: 39.47  E-value: 1.55e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2691746092  154 EDEKRQAEEQARKQEEQKRQADEQARKQHEEQKRQADE-QAR 194
Cdd:PLN02316   252 EEKRRELEKLAKEEAERERQAEEQRRREEEKAAMEADRaQAK 293
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 5-110 2.13e-03

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 38.77  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092   5 IGAALFSIAFILLILCIISFFkkngkakqygcptVILFMISIILITTGTTK-SEHPVVEFFSTLSFILFIFFLVIAILSV 83
Cdd:TIGR00797  68 LGRQAQQSLLLALLLGLPVLL-------------VGYFFIDPLLSLMGADGeVAELAQDYLRILILGIPAYLLNFVLRGF 134

                          90       100
                  ....*....|....*....|....*..
gi 2691746092  84 IKKTGVAKKQFIITAVLFVIFVALLVI 110
Cdd:TIGR00797 135 LRGQGDTKTPMYITLIGNVINIILNYI 161
ABC2_membrane_3 pfam12698
ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter ...
 5-112 2.72e-03

ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter family pfam01061.


Pssm-ID: 463674 [Multi-domain]  Cd Length: 345  Bit Score: 38.53  E-value: 2.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092   5 IGAALFSIAFILLILCIISFFKKNGKAKQYGCPtVILFMISIILITTGTTKSEHPVVEFFStlsfILFIFFLVIAILSVI 84
Cdd:pfam12698 243 LLFLLYGLAYIALGYLLGSLFKNSEDAQSIIGI-VILLLSGFFGGLFPLEDPPSFLQWIFS----IIPFFSPIDGLLRLI 317

                          90       100
                  ....*....|....*....|....*....
gi 2691746092  85 kkTGVAKKQFIIT-AVLFVIFVALLVISA 112
Cdd:pfam12698 318 --YGDSLWEIAPSlIILLLFAVVLLLLAL 344
rne PRK10811
ribonuclease E; Reviewed
 128-192 2.78e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 38.87  E-value: 2.78e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2691746092  128 NNEEQKNSEQKKELEKKEADEKTQKQEDEKRQ---AEEQARKQEEqKRQADEQARKQH-EEQKRQADEQ 192
Cdd:PRK10811   642 NRRQAQQQTAETRESQQAEVTEKARTQDEQQQaprRERQRRRNDE-KRQAQQEAKALNvEEQSVQETEQ 709
PTZ00121 PTZ00121
MAEBL; Provisional
 112-191 2.97e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 2.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092  112 APSSEKTTATSTKVASNNEEQKNSEQKKELEKKEADEKTQKQEDEKRQAEEqARKQEEQKRQADEQARKQheEQKRQADE 191
Cdd:PTZ00121  1359 AEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADE-LKKAAAAKKKADEAKKKA--EEKKKADE 1435
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 151-194 3.81e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 38.18  E-value: 3.81e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2691746092 151 QKQEDEKRQA---EEQARK--------------QEEQKRQADEQARKQHE-EQKRQADEQAR 194
Cdd:pfam17380 498 EKELEERKQAmieEERKRKllekemeerqkaiyEEERRREAEEERRKQQEmEERRRIQEQMR 559
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 151-194 3.83e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 37.90  E-value: 3.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2691746092 151 QKQEDEKRQAEEQARKQEEQKRQADEQA--RKQHEEQKRQADEQAR 194
Cdd:TIGR02794 112 KQAEEKQKQAEEAKAKQAAEAKAKAEAEaeRKAKEEAAKQAEEEAK 157
7tmB2_Adhesion cd15040
adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G ...
 1-110 4.08e-03

adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G protein-coupled receptors; The B2 subfamily of class B GPCRs consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320168 [Multi-domain]  Cd Length: 253  Bit Score: 37.55  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092   1 ILSNIGAALfSIAFILLILCIISFFKKngkaKQYGCPTVILF------MISIILITTGTTKSEHPVV-EFFSTLS--FIL 71
Cdd:cd15040     6 IITYIGCGL-SLLGLLLTIITYILFRK----LRKRKPTKILLnlclalLLANLLFLFGINSTDNPVLcTAVAALLhyFLL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2691746092  72 FIFF--LVIAIL---SVIKKTGVAKKQFIITAVLFVIFVALLVI 110
Cdd:cd15040    81 ASFMwmLVEALLlylRLVKVFGTYPRHFILKYALIGWGLPLIIV 124
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 151-194 4.24e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 38.01  E-value: 4.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2691746092 151 QKQEDEKRQAEEQARKQ------EEQKRQAD--EQARKQHEEQKRQADEQAR 194
Cdd:pfam15709 440 QQEEAERAEAEKQRQKElemqlaEEQKRLMEmaEEERLEYQRQKQEAEEKAR 491
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 116-194 4.64e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 38.18  E-value: 4.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092 116 EKTTATSTKVASNNEEQKNSEQKKELEKKEADEKTQKQEDEKRQAEEQAR-----KQEEQKRQAD-EQARKQHEEQKRQA 189
Cdd:pfam17380 397 ELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERARemervRLEEQERQQQvERLRQQEEERKRKK 476


                  ....*
gi 2691746092 190 DEQAR 194
Cdd:pfam17380 477 LELEK 481
DUF4064 pfam13273
Protein of unknown function (DUF4064);
1-104 5.75e-03

Protein of unknown function (DUF4064);


Pssm-ID: 433076  Cd Length: 102  Bit Score: 35.36  E-value: 5.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092   1 ILSNIGAALFSIAFILLIlcIISFFKKNGKAKQYgcptvilFMISIILITTGTTksehpVVEFFSTLSFILFIFFLVIAI 80
Cdd:pfam13273   7 ILGIIGGILGILFGLFAL--LFLFLIGSGEFSQE-------LTEGAASGEDASA-----TLEIFSTLLLVLGIIALIASV 72

                          90       100       110
                  ....*....|....*....|....*....|
gi 2691746092  81 LSVI------KKTGVAKKQFIITAVLFVIF 104
Cdd:pfam13273  73 LGIVgalllkKNKKLSGILFIIAGILSLFT 102
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 151-194 6.45e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 37.62  E-value: 6.45e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2691746092 151 QKQEDEK-RQAEEQARKQEEQKR-----------------QADEQARKQHEEQKRQADEQAR 194
Cdd:pfam15709 445 ERAEAEKqRQKELEMQLAEEQKRlmemaeeerleyqrqkqEAEEKARLEAEERRQKEEEAAR 506
PTZ00121 PTZ00121
MAEBL; Provisional
 114-191 7.75e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 37.43  E-value: 7.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2691746092  114 SSEKTTATSTKVASNNEEQKNSEQKKELEKKEADEKTQKQEDEKRQAEEqARKQEEqKRQADE-----QARKQHE----E 184
Cdd:PTZ00121  1466 AEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADE-AKKAEE-AKKADEakkaeEAKKADEakkaE 1543


                   ....*..
gi 2691746092  185 QKRQADE 191
Cdd:PTZ00121  1544 EKKKADE 1550
Casc1_N pfam15927
Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally ...
 156-194 8.02e-03

Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.


Pssm-ID: 464947 [Multi-domain]  Cd Length: 201  Bit Score: 36.57  E-value: 8.02e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2691746092 156 EKRQAEEQARKQEEQKRQADEQA-RKQHEEQKRQADEQAR 194
Cdd:pfam15927   1 ARLREEEEERLRAEEEEAERLEEeRREEEEEERLAAEQDR 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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