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Conserved domains on  [gi|2697415825|ref|WP_336475663|]
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DNA methyltransferase, partial [Escherichia coli]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 1-72 3.85e-39

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member PRK11524:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 284  Bit Score: 130.23  E-value: 3.85e-39
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2697415825   1 LDPFAGSFTTGAVAIASGRKFIGIEINSEYIKMGLRRLDVASHYSAEELAKVKKRKTGNLSKRSRLSEVDPD 72
Cdd:PRK11524  213 LDPFAGSFTTGAVAKASGRKFIGIEINSEYIKMGLRRLDVASHYSAEELAKVKKRKTGNLSKKSRLSEVDPD 284
 
Name Accession Description Interval E-value
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
1-72 3.85e-39

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 130.23  E-value: 3.85e-39
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2697415825   1 LDPFAGSFTTGAVAIASGRKFIGIEINSEYIKMGLRRLDVASHYSAEELAKVKKRKTGNLSKRSRLSEVDPD 72
Cdd:PRK11524  213 LDPFAGSFTTGAVAKASGRKFIGIEINSEYIKMGLRRLDVASHYSAEELAKVKKRKTGNLSKKSRLSEVDPD 284
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
1-50 2.35e-18

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 74.96  E-value: 2.35e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2697415825   1 LDPFAGSFTTGAVAIASGRKFIGIEINSEYIKMGLRRLDVASHYSAEELA 50
Cdd:COG0863   187 LDPFAGSGTTLVAAERLGRRFIGIEIDPEYVEVARRRLEEATGLEFEELA 236
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 1-33 1.91e-13

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 62.03  E-value: 1.91e-13
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2697415825   1 LDPFAGSFTTGAVAIASGRKFIGIEINSEYIKM 33
Cdd:pfam01555 186 LDPFAGSGTTGAAAKELGRNFIGIEIEEEYVEI 218
 
Name Accession Description Interval E-value
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
1-72 3.85e-39

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 130.23  E-value: 3.85e-39
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2697415825   1 LDPFAGSFTTGAVAIASGRKFIGIEINSEYIKMGLRRLDVASHYSAEELAKVKKRKTGNLSKRSRLSEVDPD 72
Cdd:PRK11524  213 LDPFAGSFTTGAVAKASGRKFIGIEINSEYIKMGLRRLDVASHYSAEELAKVKKRKTGNLSKKSRLSEVDPD 284
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
1-50 2.35e-18

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 74.96  E-value: 2.35e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2697415825   1 LDPFAGSFTTGAVAIASGRKFIGIEINSEYIKMGLRRLDVASHYSAEELA 50
Cdd:COG0863   187 LDPFAGSGTTLVAAERLGRRFIGIEIDPEYVEVARRRLEEATGLEFEELA 236
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 1-33 1.91e-13

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 62.03  E-value: 1.91e-13
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2697415825   1 LDPFAGSFTTGAVAIASGRKFIGIEINSEYIKM 33
Cdd:pfam01555 186 LDPFAGSGTTGAAAKELGRNFIGIEIEEEYVEI 218
PRK13699 PRK13699
putative methylase; Provisional
 1-38 6.68e-09

putative methylase; Provisional


Pssm-ID: 184255  Cd Length: 227  Bit Score: 49.83  E-value: 6.68e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2697415825   1 LDPFAGSFTTGAVAIASGRKFIGIEINSEYIKMGLRRL 38
Cdd:PRK13699  168 LDPFAGSGSTCVAALQSGRRYIGIELLEQYHRAGQQRL 205
Mod COG2189
Adenine specific DNA methylase Mod [Replication, recombination and repair];
1-38 1.73e-06

Adenine specific DNA methylase Mod [Replication, recombination and repair];


Pssm-ID: 441792 [Multi-domain]  Cd Length: 491  Bit Score: 43.22  E-value: 1.73e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2697415825   1 LDPFAGSFTTGAVAIASG------RKFIGIEINSEYIKMGLRRL 38
Cdd:COG2189   325 LDFFAGSGTTAHAVMKLNaedggnRRFILVQLGEYADTVTKERL 368
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 1-48 7.90e-04

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 35.69  E-value: 7.90e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2697415825   1 LDPFAGsftTGAVAIA---SGRKFIGIEINSEYIKMGLRRLDvasHYSAEE 48
Cdd:COG1041    31 LDPFCG---TGTILIEaglLGRRVIGSDIDPKMVEGARENLE---HYGYED 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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