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Conserved domains on  [gi|2698607710|ref|WP_336884520|]
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AAA family ATPase [Streptococcus entericus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cbbX_cfxQ super family cl30748
probable Rubsico expression protein CbbX; Proteins in this family are now designated CbbX. ...
 303-569 3.31e-75

probable Rubsico expression protein CbbX; Proteins in this family are now designated CbbX. Some previously were CfxQ (carbon fixation Q). Its gene is often found immmediately downstream of the Rubisco large and small chain genes, and it is suggested to be necessary for Rubisco expression. CbbX has been shown to be necessary for photoautotrophic growth. This protein belongs to the larger family of pfam00004, ATPase family Associated with various cellular Activities. Within that larger family, members of this family are most closely related to the stage V sporulation protein K, or SpoVK, in endospore-forming bacteria such as Bacillus subtilis.


The actual alignment was detected with superfamily member TIGR02880:

Pssm-ID: 200217 [Multi-domain]  Cd Length: 284  Bit Score: 240.90  E-value: 3.31e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 303 GLKKTPEDTLRELIGLKAVKNLLSQQIAFNKVNYLRKQHGVINETSNHHLVFSGNPGTGKTEVARLYTKILYNNKIIQED 382
Cdd:TIGR02880  12 GITEVLDQLDRELIGLKPVKTRIREIAALLLVERARQKLGLASAAPTLHMSFTGNPGTGKTTVALRMAQILHRLGYVRKG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 383 KLVEVGRADLIGEYIGSTAPKVKNVFDKAKGGVLFIDEAYSLI-PRHEKDYGHEAIATIIQEMENRRDEVLVIFAGYEDL 461
Cdd:TIGR02880  92 HLVSVTRDDLVGQYIGHTAPKTKEVLKRAMGGVLFIDEAYYLYrPDNERDYGQEAIEILLQVMENNRDDLVVILAGYKDR 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 462 MKEFLDINPGLSSRVSQEIIFEDYSSDELFAIFELMISRKQYHLTDDCKNKLCHHFSELKPDSHFGNARYVRKLVDHIIV 541
Cdd:TIGR02880 172 MDSFFESNPGFSSRVAHHIDFPDYSDEELLEIAGLMLDEQQYRFTAEAETAFADYIALRRTQPHFANARSIRNALDRARL 251

                         250       260
                  ....*....|....*....|....*...
gi 2698607710 542 CQAQRVINMEDSHLSNlEILSLVTLEDI 569
Cdd:TIGR02880 252 RQANRLFTASDGVLDK-SDLSTIAPEDI 278
 
Name Accession Description Interval E-value
cbbX_cfxQ TIGR02880
probable Rubsico expression protein CbbX; Proteins in this family are now designated CbbX. ...
 303-569 3.31e-75

probable Rubsico expression protein CbbX; Proteins in this family are now designated CbbX. Some previously were CfxQ (carbon fixation Q). Its gene is often found immmediately downstream of the Rubisco large and small chain genes, and it is suggested to be necessary for Rubisco expression. CbbX has been shown to be necessary for photoautotrophic growth. This protein belongs to the larger family of pfam00004, ATPase family Associated with various cellular Activities. Within that larger family, members of this family are most closely related to the stage V sporulation protein K, or SpoVK, in endospore-forming bacteria such as Bacillus subtilis.


Pssm-ID: 200217 [Multi-domain]  Cd Length: 284  Bit Score: 240.90  E-value: 3.31e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 303 GLKKTPEDTLRELIGLKAVKNLLSQQIAFNKVNYLRKQHGVINETSNHHLVFSGNPGTGKTEVARLYTKILYNNKIIQED 382
Cdd:TIGR02880  12 GITEVLDQLDRELIGLKPVKTRIREIAALLLVERARQKLGLASAAPTLHMSFTGNPGTGKTTVALRMAQILHRLGYVRKG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 383 KLVEVGRADLIGEYIGSTAPKVKNVFDKAKGGVLFIDEAYSLI-PRHEKDYGHEAIATIIQEMENRRDEVLVIFAGYEDL 461
Cdd:TIGR02880  92 HLVSVTRDDLVGQYIGHTAPKTKEVLKRAMGGVLFIDEAYYLYrPDNERDYGQEAIEILLQVMENNRDDLVVILAGYKDR 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 462 MKEFLDINPGLSSRVSQEIIFEDYSSDELFAIFELMISRKQYHLTDDCKNKLCHHFSELKPDSHFGNARYVRKLVDHIIV 541
Cdd:TIGR02880 172 MDSFFESNPGFSSRVAHHIDFPDYSDEELLEIAGLMLDEQQYRFTAEAETAFADYIALRRTQPHFANARSIRNALDRARL 251

                         250       260
                  ....*....|....*....|....*...
gi 2698607710 542 CQAQRVINMEDSHLSNlEILSLVTLEDI 569
Cdd:TIGR02880 252 RQANRLFTASDGVLDK-SDLSTIAPEDI 278
cbbX CHL00181
CbbX; Provisional
 313-568 1.21e-69

CbbX; Provisional


Pssm-ID: 177083 [Multi-domain]  Cd Length: 287  Bit Score: 226.52  E-value: 1.21e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 313 RELIGLKAVKNLLSQQIAFNKVNYLRKQHGVINETSNHHLVFSGNPGTGKTEVARLYTKILYNNKIIQEDKLVEVGRADL 392
Cdd:CHL00181   23 EELVGLAPVKTRIREIAALLLIDRLRKNLGLTSSNPGLHMSFTGSPGTGKTTVALKMADILYKLGYIKKGHLLTVTRDDL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 393 IGEYIGSTAPKVKNVFDKAKGGVLFIDEAYSLI-PRHEKDYGHEAIATIIQEMENRRDEVLVIFAGYEDLMKEFLDINPG 471
Cdd:CHL00181  103 VGQYIGHTAPKTKEVLKKAMGGVLFIDEAYYLYkPDNERDYGSEAIEILLQVMENQRDDLVVIFAGYKDRMDKFYESNPG 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 472 LSSRVSQEIIFEDYSSDELFAIFELMISRKQYHLTDDCKNKLCHHFSELKPDSHFGNARYVRKLVDHIIVCQAQRVINME 551
Cdd:CHL00181  183 LSSRIANHVDFPDYTPEELLQIAKIMLEEQQYQLTPEAEKALLDYIKKRMEQPLFANARSVRNALDRARMRQANRIFESG 262

                         250
                  ....*....|....*..
gi 2698607710 552 DSHLSNLEilsLVTLED 568
Cdd:CHL00181  263 GRVLTKAD---LVTIEA 276
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 257-577 2.93e-46

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 167.78  E-value: 2.93e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 257 SSINNARDIRQLVQEIIEFAVQSGFDPSDDKEMHLENFLITPESQIGLK----KTPEDTLRELIGLKAVKNLLSQQIA-F 331
Cdd:COG0464    97 LLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEeellELREAILDDLGGLEEVKEELRELVAlP 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 332 NKVNYLRKQHGVineTSNHHLVFSGNPGTGKTEVARLYTKILynnkiiqEDKLVEVGRADLIGEYIGSTAPKVKNVFDKA 411
Cdd:COG0464   177 LKRPELREEYGL---PPPRGLLLYGPPGTGKTLLARALAGEL-------GLPLIEVDLSDLVSKYVGETEKNLREVFDKA 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 412 KG---GVLFIDEAYSLIPR--HEKD-YGHEAIATIIQEMENRRDEVLVIFAGYedlmkEFLDINPGLSSRVSQEIIFEDY 485
Cdd:COG0464   247 RGlapCVLFIDEADALAGKrgEVGDgVGRRVVNTLLTEMEELRSDVVVIAATN-----RPDLLDPALLRRFDEIIFFPLP 321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 486 SSDELFAIFELMISRKQyhLTDDCKnklchhFSELKPDSHFGNARYVRKLVDHIIvcqaqrvinmedsHLSNLEILSLVT 565
Cdd:COG0464   322 DAEERLEIFRIHLRKRP--LDEDVD------LEELAEATEGLSGADIRNVVRRAA-------------LQALRLGREPVT 380

                         330
                  ....*....|..
gi 2698607710 566 LEDIVNALESFE 577
Cdd:COG0464   381 TEDLLEALERED 392
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 352-483 8.76e-14

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 68.39  E-value: 8.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 352 LVFSGNPGTGKTEVARLYTKILYNNkiiqedkLVEVGRADLIGEYIGSTAPKVKNVFDKAK---GGVLFIDEAYSLIPRH 428
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAP-------FIEISGSELVSKYVGESEKRLRELFEAAKklaPCVIFIDEIDALAGSR 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2698607710 429 EKDYGHEAIATI------IQEMENRRDEVLVIFAGYedlmkEFLDINPGLSSRVSQEIIFE 483
Cdd:pfam00004  74 GSGGDSESRRVVnqllteLDGFTSSNSKVIVIAATN-----RPDKLDPALLGRFDRIIEFP 129
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 342-483 1.36e-09

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 57.16  E-value: 1.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 342 GVINETSNHHLVFSGNPGTGKTEVARLytkiLYNNKIIQEDKLVEVGRADLIGEYIGSTAPKVKNVFD------KAKGGV 415
Cdd:cd00009    12 EALELPPPKNLLLYGPPGTGKTTLARA----IANELFRPGAPFLYLNASDLLEGLVVAELFGHFLVRLlfelaeKAKPGV 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2698607710 416 LFIDEAYSLiPRHEKDYGHEAIATIIQEMEnRRDEVLVIFAGYEDLMkefLDINPGLSSRVSQEIIFE 483
Cdd:cd00009    88 LFIDEIDSL-SRGAQNALLRVLETLNDLRI-DRENVRVIGATNRPLL---GDLDRALYDRLDIRIVIP 150
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 348-482 1.45e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 45.44  E-value: 1.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710  348 SNHHLVFSGNPGTGKTEVARL--------YTKILYNN--KIIQEDKLVEVGRADLIGEYIGSTAPKVKNVFDKAKG---G 414
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARAlarelgppGGGVIYIDgeDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKlkpD 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2698607710  415 VLFIDEAYSLIPRHEKDYGHEAIATIIQEMENRRDEVLVIFAgyedlMKEFLDINPGLSSRVSQEIIF 482
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLLLKSEKNLTVILT-----TNDEKDLGPALLRRRFDRRIV 143
 
Name Accession Description Interval E-value
cbbX_cfxQ TIGR02880
probable Rubsico expression protein CbbX; Proteins in this family are now designated CbbX. ...
 303-569 3.31e-75

probable Rubsico expression protein CbbX; Proteins in this family are now designated CbbX. Some previously were CfxQ (carbon fixation Q). Its gene is often found immmediately downstream of the Rubisco large and small chain genes, and it is suggested to be necessary for Rubisco expression. CbbX has been shown to be necessary for photoautotrophic growth. This protein belongs to the larger family of pfam00004, ATPase family Associated with various cellular Activities. Within that larger family, members of this family are most closely related to the stage V sporulation protein K, or SpoVK, in endospore-forming bacteria such as Bacillus subtilis.


Pssm-ID: 200217 [Multi-domain]  Cd Length: 284  Bit Score: 240.90  E-value: 3.31e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 303 GLKKTPEDTLRELIGLKAVKNLLSQQIAFNKVNYLRKQHGVINETSNHHLVFSGNPGTGKTEVARLYTKILYNNKIIQED 382
Cdd:TIGR02880  12 GITEVLDQLDRELIGLKPVKTRIREIAALLLVERARQKLGLASAAPTLHMSFTGNPGTGKTTVALRMAQILHRLGYVRKG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 383 KLVEVGRADLIGEYIGSTAPKVKNVFDKAKGGVLFIDEAYSLI-PRHEKDYGHEAIATIIQEMENRRDEVLVIFAGYEDL 461
Cdd:TIGR02880  92 HLVSVTRDDLVGQYIGHTAPKTKEVLKRAMGGVLFIDEAYYLYrPDNERDYGQEAIEILLQVMENNRDDLVVILAGYKDR 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 462 MKEFLDINPGLSSRVSQEIIFEDYSSDELFAIFELMISRKQYHLTDDCKNKLCHHFSELKPDSHFGNARYVRKLVDHIIV 541
Cdd:TIGR02880 172 MDSFFESNPGFSSRVAHHIDFPDYSDEELLEIAGLMLDEQQYRFTAEAETAFADYIALRRTQPHFANARSIRNALDRARL 251

                         250       260
                  ....*....|....*....|....*...
gi 2698607710 542 CQAQRVINMEDSHLSNlEILSLVTLEDI 569
Cdd:TIGR02880 252 RQANRLFTASDGVLDK-SDLSTIAPEDI 278
cbbX CHL00181
CbbX; Provisional
 313-568 1.21e-69

CbbX; Provisional


Pssm-ID: 177083 [Multi-domain]  Cd Length: 287  Bit Score: 226.52  E-value: 1.21e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 313 RELIGLKAVKNLLSQQIAFNKVNYLRKQHGVINETSNHHLVFSGNPGTGKTEVARLYTKILYNNKIIQEDKLVEVGRADL 392
Cdd:CHL00181   23 EELVGLAPVKTRIREIAALLLIDRLRKNLGLTSSNPGLHMSFTGSPGTGKTTVALKMADILYKLGYIKKGHLLTVTRDDL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 393 IGEYIGSTAPKVKNVFDKAKGGVLFIDEAYSLI-PRHEKDYGHEAIATIIQEMENRRDEVLVIFAGYEDLMKEFLDINPG 471
Cdd:CHL00181  103 VGQYIGHTAPKTKEVLKKAMGGVLFIDEAYYLYkPDNERDYGSEAIEILLQVMENQRDDLVVIFAGYKDRMDKFYESNPG 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 472 LSSRVSQEIIFEDYSSDELFAIFELMISRKQYHLTDDCKNKLCHHFSELKPDSHFGNARYVRKLVDHIIVCQAQRVINME 551
Cdd:CHL00181  183 LSSRIANHVDFPDYTPEELLQIAKIMLEEQQYQLTPEAEKALLDYIKKRMEQPLFANARSVRNALDRARMRQANRIFESG 262

                         250
                  ....*....|....*..
gi 2698607710 552 DSHLSNLEilsLVTLED 568
Cdd:CHL00181  263 GRVLTKAD---LVTIEA 276
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 312-575 5.69e-59

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 206.23  E-value: 5.69e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 312 LRELIGLKAVKNLLSQQIAFNKVNYLRKQHGVINETSNHHLVFSGNPGTGKTEVARLYTKILYNNKIIQEDKLVEVGRAD 391
Cdd:TIGR03922 275 LAEQIGLERVKRQVAALKSSTAMALARAERGLPVAQTSNHMLFAGPPGTGKTTIARVVAKIYCGLGVLRKPLVREVSRAD 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 392 LIGEYIGSTAPKVKNVFDKAKGGVLFIDEAYSLIPRHE---KDYGHEAIATIIQEMENRRDEVLVIFAGYEDLMKEFLDI 468
Cdd:TIGR03922 355 LIGQYIGESEAKTNEIIDSALGGVLFLDEAYTLVETGYgqkDPFGLEAIDTLLARMENDRDRLVVIGAGYRKDLDKFLEV 434

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 469 NPGLSSRVSQEIIFEDYSSDELFAIFELMISRKQYHLTDDCKNKLCHHFSELKPDSHF-------------GNARYVRKL 535
Cdd:TIGR03922 435 NEGLRSRFTRVIEFPSYSPDELVEIARRMATERDSVLDDAAADALLEAATTLAQDTTPdangdlrrgldiaGNGRFVRNV 514

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2698607710 536 VDHIIVCQAQRVINMEDSHLSNLEILSLVTLEDIVNALES 575
Cdd:TIGR03922 515 VERAEEERDFRLDHSDRLDAVTVDDLMEITADDVARAVAS 554
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 257-577 2.93e-46

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 167.78  E-value: 2.93e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 257 SSINNARDIRQLVQEIIEFAVQSGFDPSDDKEMHLENFLITPESQIGLK----KTPEDTLRELIGLKAVKNLLSQQIA-F 331
Cdd:COG0464    97 LLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEeellELREAILDDLGGLEEVKEELRELVAlP 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 332 NKVNYLRKQHGVineTSNHHLVFSGNPGTGKTEVARLYTKILynnkiiqEDKLVEVGRADLIGEYIGSTAPKVKNVFDKA 411
Cdd:COG0464   177 LKRPELREEYGL---PPPRGLLLYGPPGTGKTLLARALAGEL-------GLPLIEVDLSDLVSKYVGETEKNLREVFDKA 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 412 KG---GVLFIDEAYSLIPR--HEKD-YGHEAIATIIQEMENRRDEVLVIFAGYedlmkEFLDINPGLSSRVSQEIIFEDY 485
Cdd:COG0464   247 RGlapCVLFIDEADALAGKrgEVGDgVGRRVVNTLLTEMEELRSDVVVIAATN-----RPDLLDPALLRRFDEIIFFPLP 321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 486 SSDELFAIFELMISRKQyhLTDDCKnklchhFSELKPDSHFGNARYVRKLVDHIIvcqaqrvinmedsHLSNLEILSLVT 565
Cdd:COG0464   322 DAEERLEIFRIHLRKRP--LDEDVD------LEELAEATEGLSGADIRNVVRRAA-------------LQALRLGREPVT 380

                         330
                  ....*....|..
gi 2698607710 566 LEDIVNALESFE 577
Cdd:COG0464   381 TEDLLEALERED 392
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
312-500 1.67e-19

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 88.02  E-value: 1.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 312 LRELIGLKAVKNLLSQQIAFNKVNYLRKQHGviNETSnHHLVFSGNPGTGKTEVARlytkilynnKIIQEDK--LVEVGR 389
Cdd:COG1223     1 LDDVVGQEEAKKKLKLIIKELRRRENLRKFG--LWPP-RKILFYGPPGTGKTMLAE---------ALAGELKlpLLTVRL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 390 ADLIGEYIGSTAPKVKNVFDKAK--GGVLFIDEAYSLIPR----HEKDYGHEAIATIIQEMENRRDEVLVIFAGYEdlmK 463
Cdd:COG1223    69 DSLIGSYLGETARNLRKLFDFARraPCVIFFDEFDAIAKDrgdqNDVGEVKRVVNALLQELDGLPSGSVVIAATNH---P 145

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2698607710 464 EFLDinPGLSSRVSQEIIFEDYSSDELFAIFELMISR 500
Cdd:COG1223   146 ELLD--SALWRRFDEVIEFPLPDKEERKEILELNLKK 180
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 352-483 8.76e-14

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 68.39  E-value: 8.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 352 LVFSGNPGTGKTEVARLYTKILYNNkiiqedkLVEVGRADLIGEYIGSTAPKVKNVFDKAK---GGVLFIDEAYSLIPRH 428
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAP-------FIEISGSELVSKYVGESEKRLRELFEAAKklaPCVIFIDEIDALAGSR 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2698607710 429 EKDYGHEAIATI------IQEMENRRDEVLVIFAGYedlmkEFLDINPGLSSRVSQEIIFE 483
Cdd:pfam00004  74 GSGGDSESRRVVnqllteLDGFTSSNSKVIVIAATN-----RPDKLDPALLGRFDRIIEFP 129
AAA_lid_6 pfam17866
AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 507-569 7.64e-10

AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465539 [Multi-domain]  Cd Length: 60  Bit Score: 54.88  E-value: 7.64e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2698607710 507 DDCKNKLCHHFSELKPDSHFGNARYVRKLVDHIIVCQAQRVINMEDshlSNLEILSLVTLEDI 569
Cdd:pfam17866   1 PEAEEKLRELLERARRDPNFGNARFVRNLLERAIRRQALRLAAEEE---LTREDLMTLTAEDF 60
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 342-483 1.36e-09

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 57.16  E-value: 1.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 342 GVINETSNHHLVFSGNPGTGKTEVARLytkiLYNNKIIQEDKLVEVGRADLIGEYIGSTAPKVKNVFD------KAKGGV 415
Cdd:cd00009    12 EALELPPPKNLLLYGPPGTGKTTLARA----IANELFRPGAPFLYLNASDLLEGLVVAELFGHFLVRLlfelaeKAKPGV 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2698607710 416 LFIDEAYSLiPRHEKDYGHEAIATIIQEMEnRRDEVLVIFAGYEDLMkefLDINPGLSSRVSQEIIFE 483
Cdd:cd00009    88 LFIDEIDSL-SRGAQNALLRVLETLNDLRI-DRENVRVIGATNRPLL---GDLDRALYDRLDIRIVIP 150
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 297-456 3.65e-08

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 55.40  E-value: 3.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 297 TPESQIGLKKTPEDTLRELIGLKAVKNLLSQQI--------AFNKVNyLRKQHGVInetsnhhlvFSGNPGTGKTEVArl 368
Cdd:COG1222    62 TPRGTAVPAESPDVTFDDIGGLDEQIEEIREAVelplknpeLFRKYG-IEPPKGVL---------LYGPPGTGKTLLA-- 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 369 ytKILYNNkiiQEDKLVEVGRADLIGEYIGSTAPKVKNVFDKAKG---GVLFIDEAYSLIPRheKDYGHEA------IAT 439
Cdd:COG1222   130 --KAVAGE---LGAPFIRVRGSELVSKYIGEGARNVREVFELAREkapSIIFIDEIDAIAAR--RTDDGTSgevqrtVNQ 202

                         170
                  ....*....|....*....
gi 2698607710 440 IIQEME--NRRDEVLVIFA 456
Cdd:COG1222   203 LLAELDgfESRGDVLIIAA 221
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 310-456 1.12e-07

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 51.91  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 310 DTLRELIGLKAVKNLLSQQIAfnkvnyLRKQHGVInetsnhhlvFSGNPGTGKTEVARlytkILYNNKIIQedkLVEVGR 389
Cdd:cd19503    10 ASLKELIELPLKYPELFRALG------LKPPRGVL---------LHGPPGTGKTLLAR----AVANEAGAN---FLSISG 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2698607710 390 ADLIGEYIGSTAPKVKNVFDKAKG---GVLFIDEAYSLIPRHEKDyGHEA----IATIIQEME--NRRDEVLVIFA 456
Cdd:cd19503    68 PSIVSKYLGESEKNLREIFEEARShapSIIFIDEIDALAPKREED-QREVerrvVAQLLTLMDgmSSRGKVVVIAA 142
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 352-482 7.25e-06

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 46.12  E-value: 7.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 352 LVFSGNPGTGKTEVAR-LYTKI---LYNNKIiqedklvevgrADLIGEYIGSTAPKVKNVFDKAK---GGVLFIDEAYSL 424
Cdd:cd19481    29 ILLYGPPGTGKTLLAKaLAGELglpLIVVKL-----------SSLLSKYVGESEKNLRKIFERARrlaPCILFIDEIDAI 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2698607710 425 IPRHEKDYGH----EAIATIIQEME--NRRDEVLVIFAG-YEDLMKEFLdINPGlssRVSQEIIF 482
Cdd:cd19481    98 GRKRDSSGESgelrRVLNQLLTELDgvNSRSKVLVIAATnRPDLLDPAL-LRPG---RFDEVIEF 158
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 351-475 9.57e-06

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 45.36  E-value: 9.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 351 HLVFSGNPGTGKTEVARLYTKILYNNK--IIQEDKLVEvgRADLIG--EYIGSTAPKVKNVFDKA--KGGVLFIDEaysl 424
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSNRPvfYVQLTRDTT--EEDLFGrrNIDPGGASWVDGPLVRAarEGEIAVLDE---- 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2698607710 425 IPRHEKDygheAIATIIQEMENRR-------------DEVLVIFAGYEDLMKEFLDINPGLSSR 475
Cdd:pfam07728  75 INRANPD----VLNSLLSLLDERRlllpdggelvkaaPDGFRLIATMNPLDRGLNELSPALRSR 134
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 348-482 1.45e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 45.44  E-value: 1.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710  348 SNHHLVFSGNPGTGKTEVARL--------YTKILYNN--KIIQEDKLVEVGRADLIGEYIGSTAPKVKNVFDKAKG---G 414
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARAlarelgppGGGVIYIDgeDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKlkpD 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2698607710  415 VLFIDEAYSLIPRHEKDYGHEAIATIIQEMENRRDEVLVIFAgyedlMKEFLDINPGLSSRVSQEIIF 482
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLLLKSEKNLTVILT-----TNDEKDLGPALLRRRFDRRIV 143
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 354-456 8.46e-05

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 43.04  E-value: 8.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 354 FSGNPGTGKTEVARlytkilynnKIIQEDKL--VEVGRADLIGEYIGSTAPKVKNVFDKAKGG---VLFIDEAYSLIPRH 428
Cdd:cd19511    32 LYGPPGCGKTLLAK---------ALASEAGLnfISVKGPELFSKYVGESERAVREIFQKARQAapcIIFFDEIDSLAPRR 102

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2698607710 429 EKDYGHEA----IATIIQEME--NRRDEVLVIFA 456
Cdd:cd19511   103 GQSDSSGVtdrvVSQLLTELDgiESLKGVVVIAA 136
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
311-373 1.01e-04

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 44.80  E-value: 1.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2698607710 311 TLRELIGLKAVKNLLSQQIAFNKVN--YLrkqhgvinetsnhhlvFSGNPGTGKTEVARLYTKIL 373
Cdd:COG2812     8 TFDDVVGQEHVVRTLKNALASGRLAhaYL----------------FTGPRGVGKTTLARILAKAL 56
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 356-431 1.29e-04

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 42.80  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 356 GNPGTGKTEVArlytkilynNKIIQEDKL--VEVGRADLIGEYIGSTAPKVKNVFDKAKGG---VLFIDEAYSLIPRHEK 430
Cdd:cd19526    34 GPPGCGKTLLA---------SAIASECGLnfISVKGPELLNKYIGASEQNVRDLFSRAQSAkpcILFFDEFDSIAPKRGH 104


                  .
gi 2698607710 431 D 431
Cdd:cd19526   105 D 105
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 352-456 4.06e-04

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 41.34  E-value: 4.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 352 LVFSGNPGTGKTEVARlytkILYNNKIIQEDKLVEVGR--ADLIGEYIGSTAPKVKNVFDKAKG---GVLFIDEAYSLIP 426
Cdd:cd19517    37 VLFHGPPGTGKTLMAR----ALAAECSKGGQKVSFFMRkgADCLSKWVGEAERQLRLLFEEAYRmqpSIIFFDEIDGLAP 112

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2698607710 427 -RHEK-DYGHEAI-ATIIQEME--NRRDEVLVIFA 456
Cdd:cd19517   113 vRSSKqEQIHASIvSTLLALMDglDNRGQVVVIGA 147
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 352-427 8.82e-04

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 40.19  E-value: 8.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 352 LVFSGNPGTGKTEVAR-LYTKILYNnkiiqedkLVEVGRADLIGEYIGSTAPKVKNVFDKAKGG---VLFIDEAYSLIPR 427
Cdd:cd19527    29 ILLYGPPGTGKTLLAKaIATECSLN--------FLSVKGPELINMYIGESEANVREVFQKARDAkpcVIFFDELDSLAPS 100
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 352-447 1.83e-03

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 39.31  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 352 LVFSGNPGTGKTEVArlytkilynNKIIQEDK--LVEVGRADLIGEYIGSTAPKVKNVFDKAKGG---VLFIDEAYSLIP 426
Cdd:cd19518    37 VLLHGPPGCGKTMLA---------NAIAGELKvpFLKISATEIVSGVSGESEEKIRELFDQAISNapcIVFIDEIDAITP 107

                          90       100
                  ....*....|....*....|.
gi 2698607710 427 RHEkdygheaiaTIIQEMENR 447
Cdd:cd19518   108 KRE---------SAQREMERR 119
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 347-456 2.30e-03

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 39.03  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 347 TSNHHLVFSGNPGTGKTEVARLYTKILYNNkiiqedkLVEVGRADLIGEYIGSTAPKVKNVFDKAKGG---VLFIDEAYS 423
Cdd:cd19528    25 TPSKGVLFYGPPGCGKTLLAKAIANECQAN-------FISVKGPELLTMWFGESEANVRDIFDKARAAapcVLFFDELDS 97

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2698607710 424 LIPRHEKDYGHEAIAT------IIQEME--NRRDEVLVIFA 456
Cdd:cd19528    98 IAKARGGNIGDAGGAAdrvinqILTEMDgmNTKKNVFIIGA 138
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 356-456 3.04e-03

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 38.62  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2698607710 356 GNPGTGKTEVARlytkilynnKIIQEDKL--VEVGRADLIGEYIGSTAPKVKNVFDKAKGG---VLFIDEAYSLIPRHEK 430
Cdd:cd19530    37 GPPGCGKTLLAK---------AVANESGAnfISVKGPELLNKYVGESERAVRQVFQRARASapcVIFFDEVDALVPKRGD 107

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2698607710 431 DyGHEAIA----TIIQEME--NRRDEVLVIFA 456
Cdd:cd19530   108 G-GSWASErvvnQLLTEMDglEERSNVFVIAA 138
PRK06305 PRK06305
DNA polymerase III subunits gamma and tau; Validated
 299-373 7.25e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 180523 [Multi-domain]  Cd Length: 451  Bit Score: 38.99  E-value: 7.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2698607710 299 ESQIGLKKTPEDTLRELIGLKAVKNLLSQQIAFNKVNylrkqhgvinetsnHHLVFSGNPGTGKTEVARLYTKIL 373
Cdd:PRK06305    3 SYQVSSRKYRPQTFSEILGQDAVVAVLKNALRFNRAA--------------HAYLFSGIRGTGKTTLARIFAKAL 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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