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Conserved domains on  [gi|2721226252|ref|WP_342059206|]
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MULTISPECIES: EAL domain-containing protein [Aeromonas]

Protein Classification

EAL domain-containing protein( domain architecture ID 10005623)

EAL domain-containing protein may act as a cyclic diguanylate phosphodiesterase; similar to Borreliella burgdorferi cyclic di-GMP phosphodiesterase PdeA that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP) to pGpG

CATH:  3.20.20.450
EC:  3.1.4.52
Gene Ontology:  GO:0071111
PubMed:  15306016|26055114|19756011
SCOP:  4002400

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EAL COG2200
EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) ...
 79-633 2.60e-56

EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) [Signal transduction mechanisms];


:

Pssm-ID: 441802 [Multi-domain]  Cd Length: 576  Bit Score: 200.40  E-value: 2.60e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252  79 RLVRLDLLASKDVIELENSSDIQGVPQWFIGLGLFPEVSNESILTSGWLQLGKLKIVGHPGQAYYELWKGMSELATWFLV 158
Cdd:COG2200     1 LLLLLALLRERLLLLLLALLAEALALLLLLALLLLALASALLLAVAALLAALLAALLLLLALALLLLLLLLLLLLLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 159 GFLITTILLMRALNYLLKPLKLICEQAVEIELHHFGHAIPEPKSRELKQVVQAINTLSSKLAVQFKEQADEAENLRARVY 238
Cdd:COG2200    81 LLLALLLLLLLLLLLLLLLLLLLALLLAALLALLLLLLLLLLLLLLSLLLLLVLVLLRLALELLLALLLLALLALLDLLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 239 VDAVSGLGNRSYFVGQVNAWIAEAGQGGVMLVAVDMLDDLYREEGYAARDNMVKSIAQVLRELLDGWDGAALSRISATEY 318
Cdd:COG2200   161 LLLLRRLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLDNDGLGGAGLLLLLLLALLLLLLLARLLLALLGGGGGGFLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 319 ALLCPTDDLSQLKDLAELINSRIADLVVNPMGESGALSVVGIAGRDGDDDLSALLTKADNALGKARNERRGAVVMEGGSD 398
Cdd:COG2200   241 LLLLLAAAAAAAAALRLLLLLLLEPLLLGGGLVVVASSGGGAAAPDDGADAALLLAAAAAAAAAAAGGGRGRVVFFAAAE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 399 QGLMGRLAWRDLVQDAMARNLWRFKAQPACRFDDGTRLHAELFASI-SRDGTDYFAGQFLPAIEQFQMGAEFDKAVLEAC 477
Cdd:COG2200   321 ARARRRLALESELREALEEGELRLYYQPIVDLRTGRVVGYEALLRWrHPDGGLISPAEFIPAAERSGLIVELDRWVLERA 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 478 VPLFRQQPE----LVLAVNITAGSLCSDEFLTWLRGYLAVNGELKERLLFEIPEAAIMKHKQHVTNLVDVLREQDFLWGV 553
Cdd:COG2200   401 LRQLARWPErgldLRLSVNLSARSLLDPDFLERLLELLAEYGLPPERLVLEITESALLEDLEAAIELLARLRALGVRIAL 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 554 DHYGRHFQSLGYLEELAPAYVKVDHGYTSQVMEPGADTSFLAAVCRAAHNAGVTTIATRVEDQQQVEVLANLHIDGYQGF 633
Cdd:COG2200   481 DDFGTGYSSLSYLKRLPPDYLKIDRSFVRDIARDPRDQAIVRAIVALAHRLGLKVVAEGVETEEQLEALRELGCDYAQGY 560
 
Name Accession Description Interval E-value
EAL COG2200
EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) ...
 79-633 2.60e-56

EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) [Signal transduction mechanisms];


Pssm-ID: 441802 [Multi-domain]  Cd Length: 576  Bit Score: 200.40  E-value: 2.60e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252  79 RLVRLDLLASKDVIELENSSDIQGVPQWFIGLGLFPEVSNESILTSGWLQLGKLKIVGHPGQAYYELWKGMSELATWFLV 158
Cdd:COG2200     1 LLLLLALLRERLLLLLLALLAEALALLLLLALLLLALASALLLAVAALLAALLAALLLLLALALLLLLLLLLLLLLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 159 GFLITTILLMRALNYLLKPLKLICEQAVEIELHHFGHAIPEPKSRELKQVVQAINTLSSKLAVQFKEQADEAENLRARVY 238
Cdd:COG2200    81 LLLALLLLLLLLLLLLLLLLLLLALLLAALLALLLLLLLLLLLLLLSLLLLLVLVLLRLALELLLALLLLALLALLDLLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 239 VDAVSGLGNRSYFVGQVNAWIAEAGQGGVMLVAVDMLDDLYREEGYAARDNMVKSIAQVLRELLDGWDGAALSRISATEY 318
Cdd:COG2200   161 LLLLRRLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLDNDGLGGAGLLLLLLLALLLLLLLARLLLALLGGGGGGFLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 319 ALLCPTDDLSQLKDLAELINSRIADLVVNPMGESGALSVVGIAGRDGDDDLSALLTKADNALGKARNERRGAVVMEGGSD 398
Cdd:COG2200   241 LLLLLAAAAAAAAALRLLLLLLLEPLLLGGGLVVVASSGGGAAAPDDGADAALLLAAAAAAAAAAAGGGRGRVVFFAAAE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 399 QGLMGRLAWRDLVQDAMARNLWRFKAQPACRFDDGTRLHAELFASI-SRDGTDYFAGQFLPAIEQFQMGAEFDKAVLEAC 477
Cdd:COG2200   321 ARARRRLALESELREALEEGELRLYYQPIVDLRTGRVVGYEALLRWrHPDGGLISPAEFIPAAERSGLIVELDRWVLERA 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 478 VPLFRQQPE----LVLAVNITAGSLCSDEFLTWLRGYLAVNGELKERLLFEIPEAAIMKHKQHVTNLVDVLREQDFLWGV 553
Cdd:COG2200   401 LRQLARWPErgldLRLSVNLSARSLLDPDFLERLLELLAEYGLPPERLVLEITESALLEDLEAAIELLARLRALGVRIAL 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 554 DHYGRHFQSLGYLEELAPAYVKVDHGYTSQVMEPGADTSFLAAVCRAAHNAGVTTIATRVEDQQQVEVLANLHIDGYQGF 633
Cdd:COG2200   481 DDFGTGYSSLSYLKRLPPDYLKIDRSFVRDIARDPRDQAIVRAIVALAHRLGLKVVAEGVETEEQLEALRELGCDYAQGY 560
LapD_MoxY_N pfam16448
LapD/MoxY periplasmic domain; This domain is the N-terminal periplasmic domain of the LapD and ...
 23-146 7.22e-50

LapD/MoxY periplasmic domain; This domain is the N-terminal periplasmic domain of the LapD and MoxY receptor proteins.


Pssm-ID: 465117  Cd Length: 124  Bit Score: 169.34  E-value: 7.22e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252  23 YWVQFNSTRNYLAQQQETTVINTSTALGLALTPYLENGDKVSAESVMKAVFDGGYYRLVRLDLLASKDVIELENSSDIQG 102
Cdd:pfam16448   1 FVVSVNNARSYLEQQLQSHAQDTATSLGLSLSPYLENEDPVTAETMINAIFDSGYYRSIRLTDPDGKVLVERQNPVLIEG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2721226252 103 VPQWFIGLGLFPEVSNESILTSGWLQLGKLKIVGHPGQAYYELW 146
Cdd:pfam16448  81 VPQWFIRLVPLEPPPGEAEISSGWLQLGTLEVESHPGYAYQELW 124
EAL cd01948
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL ...
 411-633 1.01e-34

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.


Pssm-ID: 238923 [Multi-domain]  Cd Length: 240  Bit Score: 131.90  E-value: 1.01e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 411 VQDAMARNLWRFKAQPACRFDDGTRLHAELFASI-SRDGTDYFAGQFLPAIEQFQMGAEFDKAVLE-AC---VPLFRQQP 485
Cdd:cd01948     3 LRRALERGEFELYYQPIVDLRTGRIVGYEALLRWrHPEGGLISPAEFIPLAEETGLIVELGRWVLEeACrqlARWQAGGP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 486 ELVLAVNITAGSLCSDEFLTWLRGYLAVNGELKERLLFEIPEAAIMKHKQHVTNLVDVLREQDFLWGVDHYGRHFQSLGY 565
Cdd:cd01948    83 DLRLSVNLSARQLRDPDFLDRLLELLAETGLPPRRLVLEITESALIDDLEEALATLRRLRALGVRIALDDFGTGYSSLSY 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2721226252 566 LEELAPAYVKVDHGYTSQVMEPGADTSFLAAVCRAAHNAGVTTIATRVEDQQQVEVLANLHIDGYQGF 633
Cdd:cd01948   163 LKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGY 230
PRK11059 PRK11059
regulatory protein CsrD; Provisional
 138-632 2.07e-30

regulatory protein CsrD; Provisional


Pssm-ID: 236833 [Multi-domain]  Cd Length: 640  Bit Score: 126.90  E-value: 2.07e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 138 PGQAYYELWKGMSELatwfLVGFLITTILLMRALNYLLKPL----------KLICEQAVEIELHHFGHAIPEPKSRelkq 207
Cdd:PRK11059  130 PFGNYFYSLYATASL----TLAIGFIVLMLFLGVRWLRRQLagqelleeraRRILNGEREQAVAGSGYEWPRTASR---- 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 208 vvqAINTLSSKLavqfkeqaDEAENLRARV--------YVDAVSGLGNRSYFVGQVNAWIAEAG----QGGVMLVAVDML 275
Cdd:PRK11059  202 ---ALDHLLSEL--------QDAREERSRFdtfirsnaFQDAKTGLGNRLFFDNQLATLLEDQEmvgaHGVVMLIRLPDF 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 276 DDLYREEGYAARDNMVKSIAQVLRELLDGWDGAALSRISATEYALLCPTDDLSQLKDLA-ELINSrIADLVVNPMGESGA 354
Cdd:PRK11059  271 DLLQEEWGESQVEELLFELINLLSTFVMRYPGALLARYSRSDFAVLLPHRSLKEADSLAsQLLKA-VDALPPPKMLDRDD 349

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 355 LSVVGIAGRDGDDDLSALLTKADNALgkarnerRGAVvMEGGS-----------DQGLmGRLAWRDLVQDAMARNLWRFK 423
Cdd:PRK11059  350 FLHIGICAYRSGQSTEQVMEEAEMAL-------RSAQ-LQGGNgwfvydkaqlpEKGR-GSVRWRTLLEQTLVRGGPRLY 420

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 424 AQPACRFDdGTRLHAELFASIsRDGTDYF--AGQFLPAIEQFQMGAEFDKAVLEACVPLFRQQPELVLAVNITAGSLCSD 501
Cdd:PRK11059  421 QQPAVTRD-GKVHHRELFCRI-RDGQGELlsAELFMPMVQQLGLSEQYDRQVIERVLPLLRYWPEENLSINLSVDSLLSR 498

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 502 EFLTWLRGYL-AVNGELKERLLFEIPEAAIMKHKQHVTNLVDVLREQDFLWGVDHYGRHFQSLGYLEELAPAYVKVDHGY 580
Cdd:PRK11059  499 AFQRWLRDTLlQCPRSQRKRLIFELAEADVCQHISRLRPVLRMLRGLGCRLAVDQAGLTVVSTSYIKELNVELIKLHPSL 578

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2721226252 581 TSQVMEPGADTSFLAAVCRAAHNAGVTTIATRVEDQQQVEVLANLHIDGYQG 632
Cdd:PRK11059  579 VRNIHKRTENQLFVRSLVGACAGTETQVFATGVESREEWQTLQELGVSGGQG 630
EAL smart00052
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a ...
 454-633 1.25e-21

Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a variety of bacteria.


Pssm-ID: 214491 [Multi-domain]  Cd Length: 242  Bit Score: 94.21  E-value: 1.25e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252  454 GQFLPAIEQFQMGAEFDKAVLE-ACVPLFRQQ----PELVLAVNITAGSLCSDEFLTWLRGYLAVNGELKERLLFEIPEA 528
Cdd:smart00052  48 DEFIPLAEETGLIVPLGRWVLEqACQQLAEWQaqgpPPLLISINLSARQLISPDLVPRVLELLEETGLPPQRLELEITES 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252  529 AIMKHKQHVTNLVDVLREQDFLWGVDHYGRHFQSLGYLEELAPAYVKVDHGYTSQVMEPGADTSFLAAVCRAAHNAGVTT 608
Cdd:smart00052 128 VLLDDDESAVATLQRLRELGVRIALDDFGTGYSSLSYLKRLPVDLLKIDKSFVRDLQTDPEDEAIVQSIIELAQKLGLQV 207

                          170       180
                   ....*....|....*....|....*
gi 2721226252  609 IATRVEDQQQVEVLANLHIDGYQGF 633
Cdd:smart00052 208 VAEGVETPEQLDLLRSLGCDYGQGY 232
 
Name Accession Description Interval E-value
EAL COG2200
EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) ...
 79-633 2.60e-56

EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) [Signal transduction mechanisms];


Pssm-ID: 441802 [Multi-domain]  Cd Length: 576  Bit Score: 200.40  E-value: 2.60e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252  79 RLVRLDLLASKDVIELENSSDIQGVPQWFIGLGLFPEVSNESILTSGWLQLGKLKIVGHPGQAYYELWKGMSELATWFLV 158
Cdd:COG2200     1 LLLLLALLRERLLLLLLALLAEALALLLLLALLLLALASALLLAVAALLAALLAALLLLLALALLLLLLLLLLLLLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 159 GFLITTILLMRALNYLLKPLKLICEQAVEIELHHFGHAIPEPKSRELKQVVQAINTLSSKLAVQFKEQADEAENLRARVY 238
Cdd:COG2200    81 LLLALLLLLLLLLLLLLLLLLLLALLLAALLALLLLLLLLLLLLLLSLLLLLVLVLLRLALELLLALLLLALLALLDLLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 239 VDAVSGLGNRSYFVGQVNAWIAEAGQGGVMLVAVDMLDDLYREEGYAARDNMVKSIAQVLRELLDGWDGAALSRISATEY 318
Cdd:COG2200   161 LLLLRRLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLDNDGLGGAGLLLLLLLALLLLLLLARLLLALLGGGGGGFLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 319 ALLCPTDDLSQLKDLAELINSRIADLVVNPMGESGALSVVGIAGRDGDDDLSALLTKADNALGKARNERRGAVVMEGGSD 398
Cdd:COG2200   241 LLLLLAAAAAAAAALRLLLLLLLEPLLLGGGLVVVASSGGGAAAPDDGADAALLLAAAAAAAAAAAGGGRGRVVFFAAAE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 399 QGLMGRLAWRDLVQDAMARNLWRFKAQPACRFDDGTRLHAELFASI-SRDGTDYFAGQFLPAIEQFQMGAEFDKAVLEAC 477
Cdd:COG2200   321 ARARRRLALESELREALEEGELRLYYQPIVDLRTGRVVGYEALLRWrHPDGGLISPAEFIPAAERSGLIVELDRWVLERA 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 478 VPLFRQQPE----LVLAVNITAGSLCSDEFLTWLRGYLAVNGELKERLLFEIPEAAIMKHKQHVTNLVDVLREQDFLWGV 553
Cdd:COG2200   401 LRQLARWPErgldLRLSVNLSARSLLDPDFLERLLELLAEYGLPPERLVLEITESALLEDLEAAIELLARLRALGVRIAL 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 554 DHYGRHFQSLGYLEELAPAYVKVDHGYTSQVMEPGADTSFLAAVCRAAHNAGVTTIATRVEDQQQVEVLANLHIDGYQGF 633
Cdd:COG2200   481 DDFGTGYSSLSYLKRLPPDYLKIDRSFVRDIARDPRDQAIVRAIVALAHRLGLKVVAEGVETEEQLEALRELGCDYAQGY 560
LapD_MoxY_N pfam16448
LapD/MoxY periplasmic domain; This domain is the N-terminal periplasmic domain of the LapD and ...
 23-146 7.22e-50

LapD/MoxY periplasmic domain; This domain is the N-terminal periplasmic domain of the LapD and MoxY receptor proteins.


Pssm-ID: 465117  Cd Length: 124  Bit Score: 169.34  E-value: 7.22e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252  23 YWVQFNSTRNYLAQQQETTVINTSTALGLALTPYLENGDKVSAESVMKAVFDGGYYRLVRLDLLASKDVIELENSSDIQG 102
Cdd:pfam16448   1 FVVSVNNARSYLEQQLQSHAQDTATSLGLSLSPYLENEDPVTAETMINAIFDSGYYRSIRLTDPDGKVLVERQNPVLIEG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2721226252 103 VPQWFIGLGLFPEVSNESILTSGWLQLGKLKIVGHPGQAYYELW 146
Cdd:pfam16448  81 VPQWFIRLVPLEPPPGEAEISSGWLQLGTLEVESHPGYAYQELW 124
EAL pfam00563
EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL ...
 407-633 5.89e-37

EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.


Pssm-ID: 425752 [Multi-domain]  Cd Length: 235  Bit Score: 137.83  E-value: 5.89e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 407 WRDLvQDAMARNLWRFKAQPACRFDDGTRLHAELFASI-SRDGTDYFAGQFLPAIEQFQMGAEFDKAVLEACVPLFRQQ- 484
Cdd:pfam00563   1 ARAL-RRALENGEFVLYYQPIVDLRTGRVVGYEALLRWqHPDGGLISPARFLPLAEELGLIAELDRWVLEQALADLAQLq 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 485 --PELVLAVNITAGSLCSDEFLTWLRGYLAVNGELKERLLFEIPEAAIMKHKQHVTNLVDVLREQDFLWGVDHYGRHFQS 562
Cdd:pfam00563  80 lgPDIKLSINLSPASLADPGFLELLRALLKQAGPPPSRLVLEITESDLLARLEALREVLKRLRALGIRIALDDFGTGYSS 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2721226252 563 LGYLEELAPAYVKVDHGYTSQVMEPGADTSFLAAVCRAAHNAGVTTIATRVEDQQQVEVLANLHIDGYQGF 633
Cdd:pfam00563 160 LSYLLRLPPDFVKIDRSLIADIDKDGEARAIVRALIALAHSLGIKVVAEGVETEEQLEALRELGCDLVQGY 230
EAL cd01948
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL ...
 411-633 1.01e-34

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.


Pssm-ID: 238923 [Multi-domain]  Cd Length: 240  Bit Score: 131.90  E-value: 1.01e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 411 VQDAMARNLWRFKAQPACRFDDGTRLHAELFASI-SRDGTDYFAGQFLPAIEQFQMGAEFDKAVLE-AC---VPLFRQQP 485
Cdd:cd01948     3 LRRALERGEFELYYQPIVDLRTGRIVGYEALLRWrHPEGGLISPAEFIPLAEETGLIVELGRWVLEeACrqlARWQAGGP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 486 ELVLAVNITAGSLCSDEFLTWLRGYLAVNGELKERLLFEIPEAAIMKHKQHVTNLVDVLREQDFLWGVDHYGRHFQSLGY 565
Cdd:cd01948    83 DLRLSVNLSARQLRDPDFLDRLLELLAETGLPPRRLVLEITESALIDDLEEALATLRRLRALGVRIALDDFGTGYSSLSY 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2721226252 566 LEELAPAYVKVDHGYTSQVMEPGADTSFLAAVCRAAHNAGVTTIATRVEDQQQVEVLANLHIDGYQGF 633
Cdd:cd01948   163 LKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGY 230
PRK11059 PRK11059
regulatory protein CsrD; Provisional
 138-632 2.07e-30

regulatory protein CsrD; Provisional


Pssm-ID: 236833 [Multi-domain]  Cd Length: 640  Bit Score: 126.90  E-value: 2.07e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 138 PGQAYYELWKGMSELatwfLVGFLITTILLMRALNYLLKPL----------KLICEQAVEIELHHFGHAIPEPKSRelkq 207
Cdd:PRK11059  130 PFGNYFYSLYATASL----TLAIGFIVLMLFLGVRWLRRQLagqelleeraRRILNGEREQAVAGSGYEWPRTASR---- 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 208 vvqAINTLSSKLavqfkeqaDEAENLRARV--------YVDAVSGLGNRSYFVGQVNAWIAEAG----QGGVMLVAVDML 275
Cdd:PRK11059  202 ---ALDHLLSEL--------QDAREERSRFdtfirsnaFQDAKTGLGNRLFFDNQLATLLEDQEmvgaHGVVMLIRLPDF 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 276 DDLYREEGYAARDNMVKSIAQVLRELLDGWDGAALSRISATEYALLCPTDDLSQLKDLA-ELINSrIADLVVNPMGESGA 354
Cdd:PRK11059  271 DLLQEEWGESQVEELLFELINLLSTFVMRYPGALLARYSRSDFAVLLPHRSLKEADSLAsQLLKA-VDALPPPKMLDRDD 349

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 355 LSVVGIAGRDGDDDLSALLTKADNALgkarnerRGAVvMEGGS-----------DQGLmGRLAWRDLVQDAMARNLWRFK 423
Cdd:PRK11059  350 FLHIGICAYRSGQSTEQVMEEAEMAL-------RSAQ-LQGGNgwfvydkaqlpEKGR-GSVRWRTLLEQTLVRGGPRLY 420

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 424 AQPACRFDdGTRLHAELFASIsRDGTDYF--AGQFLPAIEQFQMGAEFDKAVLEACVPLFRQQPELVLAVNITAGSLCSD 501
Cdd:PRK11059  421 QQPAVTRD-GKVHHRELFCRI-RDGQGELlsAELFMPMVQQLGLSEQYDRQVIERVLPLLRYWPEENLSINLSVDSLLSR 498

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 502 EFLTWLRGYL-AVNGELKERLLFEIPEAAIMKHKQHVTNLVDVLREQDFLWGVDHYGRHFQSLGYLEELAPAYVKVDHGY 580
Cdd:PRK11059  499 AFQRWLRDTLlQCPRSQRKRLIFELAEADVCQHISRLRPVLRMLRGLGCRLAVDQAGLTVVSTSYIKELNVELIKLHPSL 578

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2721226252 581 TSQVMEPGADTSFLAAVCRAAHNAGVTTIATRVEDQQQVEVLANLHIDGYQG 632
Cdd:PRK11059  579 VRNIHKRTENQLFVRSLVGACAGTETQVFATGVESREEWQTLQELGVSGGQG 630
PRK09776 PRK09776
putative diguanylate cyclase; Provisional
 240-634 6.39e-22

putative diguanylate cyclase; Provisional


Pssm-ID: 182070 [Multi-domain]  Cd Length: 1092  Bit Score: 100.90  E-value: 6.39e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252  240 DAVSGLGNRSYFVGQVNAWIAEA---GQGGVmLVAVDMldDLYR----EEGYAARDNMVKSIAQVLRELLDGWDgaALSR 312
Cdd:PRK09776   668 DALTHLANRASFEKQLRRLLQTVnstHQRHA-LVFIDL--DRFKavndSAGHAAGDALLRELASLMLSMLRSSD--VLAR 742

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252  313 ISATEYALLCPTDDLSQlkdlAELINSRIADLV----------VNPMGESgalsvVGIAGRDGDDDLSA-LLTKADNALG 381
Cdd:PRK09776   743 LGGDEFGLLLPDCNVES----ARFIATRIISAIndyhfpwegrVYRVGAS-----AGITLIDANNHQASeVMSQADIACY 813

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252  382 KARNERRGAV-VMEGGSDQGLMGRlawRDLVQDAMAR-----NLWRFKAQPACRFDDGTRLHAELFASI-SRDGTDYFAG 454
Cdd:PRK09776   814 AAKNAGRGRVtVYEPQQAAAHSEH---RALSLAEQWRmikenQLMMLAHGVASPRIPEARNHWLISLRLwDPEGEIIDEG 890

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252  455 QFLPAIEQFQMGAEFDKAVLEAcvpLFRQ------QPELVLAVNITAGSLCSDEFLTWLRGYLAVNGELKERLLFEIPEA 528
Cdd:PRK09776   891 AFRPAAEDPALMHALDRRVIHE---FFRQaakavaSKGLSIALPLSVAGLSSPTLLPFLLEQLENSPLPPRLLHLEITET 967

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252  529 AIMKHKQHVTNLVDVLREQDFLWGVDHYGRHFQSLGYLEELAPAYVKVDHGYTSQVMEPGADTSFLAAVCRAAHNAGVTT 608
Cdd:PRK09776   968 ALLNHAESASRLVQKLRLAGCRVVLSDFGRGLSSFNYLKAFMADYLKLDGELVANLHGNLMDEMLISIIQGHAQRLGMKT 1047

                          410       420
                   ....*....|....*....|....*.
gi 2721226252  609 IATRVEDQQQVEVLANLHIDGYQGFV 634
Cdd:PRK09776  1048 IAGPVELPLVLDTLSGIGVDLAYGYA 1073
GGDEF COG2199
GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants ...
 134-393 9.14e-22

GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants [Signal transduction mechanisms];


Pssm-ID: 441801 [Multi-domain]  Cd Length: 275  Bit Score: 95.82  E-value: 9.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 134 IVGHPGQAYYELWKGMSELATWFLVGFLITTILLMRALNYLLKPLKLICEQAVEIELHHFGHAIPEPKSRELKQVVQAIN 213
Cdd:COG2199    12 LLLLLLLLLSLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLVLLLLALGLLLLALLLLSLVLELLLLLLALL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 214 TLSSKLAvQFKEQADEAENLRARVYVDAVSGLGNRSYFVGQVNAWIAEAGQGG----VMLVAVDMLDDLYREEGYAARDN 289
Cdd:COG2199    92 LLLLALE-DITELRRLEERLRRLATHDPLTGLPNRRAFEERLERELARARREGrplaLLLIDLDHFKRINDTYGHAAGDE 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 290 MVKSIAQVLRELLDgwDGAALSRISATEYALLCPTDDLSQLKDLAELINSRIADLVVNPMGESGALSV-VGIA-GRDGDD 367
Cdd:COG2199   171 VLKEVARRLRASLR--ESDLVARLGGDEFAVLLPGTDLEEAEALAERLREALEQLPFELEGKELRVTVsIGVAlYPEDGD 248

                         250       260
                  ....*....|....*....|....*.
gi 2721226252 368 DLSALLTKADNALGKARNERRGAVVM 393
Cdd:COG2199   249 SAEELLRRADLALYRAKRAGRNRVVV 274
EAL smart00052
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a ...
 454-633 1.25e-21

Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a variety of bacteria.


Pssm-ID: 214491 [Multi-domain]  Cd Length: 242  Bit Score: 94.21  E-value: 1.25e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252  454 GQFLPAIEQFQMGAEFDKAVLE-ACVPLFRQQ----PELVLAVNITAGSLCSDEFLTWLRGYLAVNGELKERLLFEIPEA 528
Cdd:smart00052  48 DEFIPLAEETGLIVPLGRWVLEqACQQLAEWQaqgpPPLLISINLSARQLISPDLVPRVLELLEETGLPPQRLELEITES 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252  529 AIMKHKQHVTNLVDVLREQDFLWGVDHYGRHFQSLGYLEELAPAYVKVDHGYTSQVMEPGADTSFLAAVCRAAHNAGVTT 608
Cdd:smart00052 128 VLLDDDESAVATLQRLRELGVRIALDDFGTGYSSLSYLKRLPVDLLKIDKSFVRDLQTDPEDEAIVQSIIELAQKLGLQV 207

                          170       180
                   ....*....|....*....|....*
gi 2721226252  609 IATRVEDQQQVEVLANLHIDGYQGF 633
Cdd:smart00052 208 VAEGVETPEQLDLLRSLGCDYGQGY 232
PRK11359 PRK11359
cyclic-di-GMP phosphodiesterase; Provisional
 201-641 1.71e-21

cyclic-di-GMP phosphodiesterase; Provisional


Pssm-ID: 183097 [Multi-domain]  Cd Length: 799  Bit Score: 99.46  E-value: 1.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 201 KSRELKQV---VQAINTLSSKLAVQFKEQADEAENLRARVYVDAVSGLGNRSYFVGQVNAWIAEAGQGGVMLVAVDMLDD 277
Cdd:PRK11359  337 KTSSGAETsafIERVADISQHLAALALEQEKSRQHIEQLIQFDPLTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVDHFQD 416

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 278 LYREEGYAARDNMVKSIAQVLRELLDgwDGAALSRISATEYALLCPTDDLSQLKDLAELINsRIADLVVNPMGESGALSV 357
Cdd:PRK11359  417 VIDSLGYAWADQALLEVVNRFREKLK--PDQYLCRIEGTQFVLVSLENDVSNITQIADELR-NVVSKPIMIDDKPFPLTL 493

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 358 -VGI---AGRDGDDdlsaLLTKADNALGKARNERRGA-VVMEGGSDQGLMGRLAWRDLVQDAMARNLWRFKAQPACRFDD 432
Cdd:PRK11359  494 sIGIsydVGKNRDY----LLSTAHNAMDYIRKNGGNGwQFFSPAMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAET 569

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 433 G--------TRLHAELFASISrdgtdyfAGQFLPAIEQFqmgAEFDK----AVLEACVPLFRQQPE----LVLAVNITAG 496
Cdd:PRK11359  570 GelygiealARWHDPLHGHVP-------PSRFIPLAEEI---GEIENigrwVIAEACRQLAEWRSQnihiPALSVNLSAL 639

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 497 SLCSDEFLTWLRGYLAVNGELKERLLFEIPEAAIMKHKQHVTNLVDVLREQDFLWGVDHYGRHFQSLGYLEELAPAYVKV 576
Cdd:PRK11359  640 HFRSNQLPNQVSDAMQAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKI 719

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2721226252 577 DHGYTSQVMEPGADTSFLAAVCRAAHNAGVTTIATRVEDQQQVEVLANLHIDGYQGFVHpAFPLP 641
Cdd:PRK11359  720 DKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFF-SRPLP 783
PRK11829 PRK11829
biofilm formation regulator HmsP; Provisional
 152-639 2.69e-17

biofilm formation regulator HmsP; Provisional


Pssm-ID: 183329 [Multi-domain]  Cd Length: 660  Bit Score: 85.76  E-value: 2.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 152 LATWFLVGfLITTILLMRALNYLL-KPLKLICEQAVEIELH--HFgHAIPEP---KSRELKQVVQAINTLSSKLAVQFKE 225
Cdd:PRK11829  150 LSTYLLLA-LVLSVSIAWCINRLIiHPLRAMAKELEDIGDHgvLH-HQLTLPahhQDDELGVLVRNYNRNQQLLADAYAD 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 226 QADEAENLrarvyvdAVSGLGNRSYFVGQVNAWIA-EAGQGG--VMLVAVDMLDDLYREEGYAARDNMVKSIAQVLRELL 302
Cdd:PRK11829  228 MGRISHRF-------PVTELPNRSLFISLLEKEIAsSTRTDHfhLLVIGIETLQEVSGAMSEAQHQQLLLTIVQRIEQCI 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 303 DgwDGAALSRISATEYALLC-----PTDDLSQLKDLAELINSRIA--DLVVNPMgesgalSVVGIAGRDGDDDLS-ALLT 374
Cdd:PRK11829  301 D--DSDLLAQLSKTEFAVLArgtrrSFPAMQLARRIMSQVTQPLFfdEITLRPS------ASIGITRYQAQQDTAeSMMR 372

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 375 KADNALGKARNERRGAV-VMEGGSDQGLMGRLAWRDLVQDAMARNLWRFKAQPACRFDDGTRLHAELFASISR-DGTDYF 452
Cdd:PRK11829  373 NASTAMMAAHHEGRNQImVFEPHLIEKTHKRLTQENDLLQAIENHDFTLFLQPQWDMKRQQVIGAEALLRWCQpDGSYVL 452

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 453 AGQFLPAIEQFQMGAEFDKAVLEACVPLF----RQQPELVLAVNITAGSLCSDEFLTWLRGYLAVNGELKERLLFEIPEA 528
Cdd:PRK11829  453 PSGFVHFAEEEGMMVPLGNWVLEEACRILadwkARGVSLPLSVNISGLQVQNKQFLPHLKTLISHYHIDPQQLLLEITET 532

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 529 AIMKHKQHVTNLVDVLREQDFLWGVDHYGRHFQSLGYLEELAPAYV---KVDHGYTSQVMEPGADTSFLAAVcraAHNAG 605
Cdd:PRK11829  533 AQIQDLDEALRLLRELQGLGLLIALDDFGIGYSSLRYLNHLKSLPIhmiKLDKSFVKNLPEDDAIARIISCV---SDVLK 609

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 2721226252 606 VTTIATRVEDQQQVEVLANLHIDGYQGFV-HPAFP 639
Cdd:PRK11829  610 VRVMAEGVETEEQRQWLLEHGIQCGQGFLfSPPLP 644
GGDEF cd01949
Diguanylate-cyclase (DGC) or GGDEF domain; Diguanylate-cyclase (DGC) or GGDEF domain: ...
 238-392 4.00e-17

Diguanylate-cyclase (DGC) or GGDEF domain; Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.


Pssm-ID: 143635 [Multi-domain]  Cd Length: 158  Bit Score: 78.75  E-value: 4.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 238 YVDAVSGLGNRSYFVGQVNAWIAEAGQGG--VMLVAVDmLD------DLYreeGYAARDNMVKSIAQVLRELLDgwDGAA 309
Cdd:cd01949     1 YTDPLTGLPNRRAFEERLERLLARARRSGrpLALLLID-IDhfkqinDTY---GHAAGDEVLKEVAERLRSSLR--ESDL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 310 LSRISATEYALLCPTDDLSQLKDLAELINSRIADLVVnPMGESGALSV-VGIA-GRDGDDDLSALLTKADNALGKARNER 387
Cdd:cd01949    75 VARLGGDEFAILLPGTDLEEAEALAERLREAIEEPFF-IDGQEIRVTAsIGIAtYPEDGEDAEELLRRADEALYRAKRSG 153


                  ....*
gi 2721226252 388 RGAVV 392
Cdd:cd01949   154 RNRVV 158
PRK13561 PRK13561
putative diguanylate cyclase; Provisional
 149-641 1.51e-11

putative diguanylate cyclase; Provisional


Pssm-ID: 184143 [Multi-domain]  Cd Length: 651  Bit Score: 67.43  E-value: 1.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 149 MSELATWFLVGFLITTILLMRALNYL-LKPLKLICEQAVEIELHH-FGHAIPEPK---SRELKQVVQAINTLSSKLAVQF 223
Cdd:PRK13561  145 LSTLVTIYLLLSLILTVAISWCINRLiVHPLRNIARELNDIPPQElVGHQLALPRlhqDDEIGMLVRSYNLNQQLLQRQY 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 224 KEQADEAENLrarvyvdAVSGLGNRSYFVGQVNAWIAEAGQGGVMLVAVDMLDDLYREEGYAARDNMVKSIAQVLRELLD 303
Cdd:PRK13561  225 EEQSRNATRF-------PVSDLPNKALLMALLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLS 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 304 gwDGAALSRISATEYALLC-----PTDDLSQLKDLAELINSRiadLVVNPMGESGALSVvGIAGRDGDDDLSALLTKADN 378
Cdd:PRK13561  298 --PRMVLAQISGYDFAIIAngvkePWHAITLGQQVLTIINER---LPIQRIQLRPSCSI-GIAMFYGDLTAEQLYSRAIS 371

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 379 ALGKARNERRGAVVMeggSDQGLMGRlAWRDLVQD-----AMARNLWRFKAQPACRFDDGTRLHAELFASISR-DGTDYF 452
Cdd:PRK13561  372 AAFTARRKGKNQIQF---FDPQQMEA-AQKRLTEEsdilnALENHQFAIWLQPQVEMRSGKLVSAEALLRMQQpDGSWDL 447

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 453 AGQFLPAIEQFQMGAEFDKAVL-EACVPLFRQQP---ELVLAVNITAGSLCSDEFLTWLRGYLAVNGELKERLLFEIPEA 528
Cdd:PRK13561  448 PEGLIDRIESCGLMVTVGHWVLeESCRLLAAWQErgiMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTES 527

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 529 AIMKHKQHVTNLVDVLREQDFLWGVDHYGRHFQSLGYLEELAPAYV---KVDHGYTSQVMEpgaDTSFLAAVCRAAHNAG 605
Cdd:PRK13561  528 RRIDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIdvlKIDKMFVDGLPE---DDSMVAAIIMLAQSLN 604

                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 2721226252 606 VTTIATRVEDQQQVEVLANLHIDGYQGFVHpAFPLP 641
Cdd:PRK13561  605 LQVIAEGVETEAQRDWLLKAGVGIAQGFLF-ARALP 639
pleD PRK09581
response regulator PleD; Reviewed
 240-394 4.54e-09

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 59.14  E-value: 4.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 240 DAVSGLGNRSYFVGQVNAWIAEAGQGG----VMLVAVD---MLDDLYreeGYAARDNMVKSIAQVLRELLDGWDGAAlsR 312
Cdd:PRK09581  295 DGLTGLHNRRYFDMHLKNLIERANERGkplsLMMIDIDhfkKVNDTY---GHDAGDEVLREFAKRLRNNIRGTDLIA--R 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 313 ISATEYALLCPTDDLSQLKDLAELINSRIADLVVNPMGESGALSV---VGIAG-RDGDDDLSALLTKADNALGKARNERR 388
Cdd:PRK09581  370 YGGEEFVVVMPDTDIEDAIAVAERIRRKIAEEPFIISDGKERLNVtvsIGVAElRPSGDTIEALIKRADKALYEAKNTGR 449


                  ....*.
gi 2721226252 389 GAVVME 394
Cdd:PRK09581  450 NRVVAL 455
PRK10551 PRK10551
cyclic di-GMP phosphodiesterase;
489-633 1.80e-05

cyclic di-GMP phosphodiesterase;


Pssm-ID: 182541 [Multi-domain]  Cd Length: 518  Bit Score: 47.68  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 489 LAVNITAGSLCSDEFLTWLRGYLAVNGELKERLLFEIPEAAiMKHKQHVTNLVDVLREQDFLWGVDHYGRHFQSLGYLEE 568
Cdd:PRK10551  352 LGINISPAHLHSDSFKADVQRLLASLPADHFQIVLEITERD-MVQEEEATKLFAWLHSQGIEIAIDDFGTGHSALIYLER 430

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2721226252 569 LAPAYVKVDHGYTSQVMEPGADTSFLAAVCRAAHNAGVTTIATRVEDQQQVEVLANLHIDGYQGF 633
Cdd:PRK10551  431 FTLDYLKIDRGFIQAIGTETVTSPVLDAVLTLAKRLNMLTVAEGVETPEQARWLRERGVNFLQGY 495
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 34-441 3.70e-04

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 43.33  E-value: 3.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252  34 LAQQQETTVINTSTALGLALTPYLENGDKVSAESVMKAVFDGGYYRLVRLDLLAsKDVIELENSSDIQGVPQWFIGLGLF 113
Cdd:COG3850     3 ELLLLALALLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLA-ALLAALLLLLSLGLLALLLALLLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 114 PEVSNESILTSGWLQLGKLKIVGHPGQAYYELWKGMSELATWFLVGFLITTILLMRALNYLLKPLKLICEQAVEIELHHF 193
Cdd:COG3850    82 LLLLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 194 GHAIPEPKSRELKQVVQAINTLSSKLAVQFKEQADEAENLRARVYVDAVSGLGNRSYFVGQVNAWIAEAGQGGVMLVAVD 273
Cdd:COG3850   162 DARVPVSGRDELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 274 MLDDLYREEGYAARDNMVKSI----AQVLRELLDGWDGAALSRISATEYALLCPTDDLSQLKDLAELINSRIADLVVNPM 349
Cdd:COG3850   242 LLLQDALAESELLALNILAGLlellLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQ 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 350 GESGALSVVGIAGRDGDDDLSALLTKADNALGKARNERRGAVVMEGGSDQGLMGRLAWRDLVQDAMARNLWRFKAQPACR 429
Cdd:COG3850   322 AIANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGA 401

                         410
                  ....*....|..
gi 2721226252 430 FDDGTRLHAELF 441
Cdd:COG3850   402 GLVDVEGGVAGE 413
PRK09966 PRK09966
diguanylate cyclase DgcN;
107-321 1.06e-03

diguanylate cyclase DgcN;


Pssm-ID: 182171 [Multi-domain]  Cd Length: 407  Bit Score: 41.92  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 107 FIGLGLFPEVSNESILTSGWLqLGKLKIVGHPGQAYYELWKGMSELATWFLVGFLITtILLMRAL-NYLLKPLKLICEQA 185
Cdd:PRK09966  118 FISHWLFPAPIIQPIRHNGET-IGEVRLTARDSSISHFIWFSLAVLTGCILLASGIA-ITLTRHLhNGLVEALKNITDVV 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 186 VEIELH-HFGHAIPEPKSRELKQVVQAINTLSSKLAV-QFKEQADEAENLRARVYvDAVSGLGNRSYFVGQVNAWIAE-A 262
Cdd:PRK09966  196 HDVRSNrNFSRRVSEERIAEFHRFALDFNSLLDEMEEwQLRLQAKNAQLLRTALH-DPLTGLANRAAFRSGINTLMNNsD 274

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2721226252 263 GQGGVMLVAVD-----MLDDLYreeGYAARDNMVKSIAQVLRELldGWDGAALSRISATEYALL 321
Cdd:PRK09966  275 ARKTSALLFLDgdnfkYINDTW---GHATGDRVLIEIAKRLAEF--GGLRHKAYRLGGDEFAMV 333
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 157-242 4.61e-03

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 39.95  E-value: 4.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 157 LVGFLITTILLMRALNYLLKPLKLICEQAVEIELHHFGHAIPEPKSRELKQVVQAINTLSSKLavqfKEQADEAEnlRAR 236
Cdd:COG5000    16 LLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQL----KEQREELE--ERR 89


                  ....*.
gi 2721226252 237 VYVDAV 242
Cdd:COG5000    90 RYLETI 95
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
152-548 9.32e-03

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 38.94  E-value: 9.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 152 LATWFLVGFLITTILLMRALNYLLKPLKLICEQAVEIELHHFGHAIPEPKSRELKQVVQAINTLSSKLAVQFKEQADEAE 231
Cdd:COG2770   214 LLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEE 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 232 NLRARVYVDAVSGLGNRSYFVGQVNAWIAEAGQGGVMLVAVDMLDDLYREEGYAA------RDNMVKSIAQVLRELLDGW 305
Cdd:COG2770   294 LAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAAdlllalALAALLLLLALELLLEAEL 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 306 DGAALSRISATEYALLCPTDDLSQLKDLAELINSRIADLVVNPMGESGALSVVGIAGRDGDDDLSALLTKADNALGKARN 385
Cdd:COG2770   374 LVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEA 453

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 386 ERRGAVVMEGGSDQGLMGRLAWRDLVQDAMARNLWRFKAQPACRFDDGTRLHAELFASISRDGTDYFAGQFLPAIEQFQM 465
Cdd:COG2770   454 EGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEGLLLLLLLEAEALEVAEELL 533

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721226252 466 GAEFDKAVLEACVPLFRQQPELVLAVNITAGSLCSDEFLTWLRGYLAVNGELKERLLFEIPEAAIMKHKQHVTNLVDVLR 545
Cdd:COG2770   534 ELEEAALLLAAAAELAALLALLLALAAVEAAALLLAALLLAAVAALLELAALLLLLLAAAEALAALELELAAAAEAALAE 613


                  ...
gi 2721226252 546 EQD 548
Cdd:COG2770   614 AEL 616
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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