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Conserved domains on  [gi|2726455299|ref|WP_342784898|]
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winged helix-turn-helix domain-containing protein [Thermofilum sp.]

Protein Classification

COG3432 family protein( domain architecture ID 10007354)

COG3432 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3432 COG3432
Predicted transcriptional regulator [Transcription];
14-95 1.71e-20

Predicted transcriptional regulator [Transcription];


:

Pssm-ID: 442658 [Multi-domain]  Cd Length: 83  Bit Score: 77.99  E-value: 1.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2726455299  14 RRKRSSLEIKFDVLKVISLGVDGPTRIMYASNTSWKVLKGILEDLLKKELIVEVG-GIQKRYRLTEKGKELLRKYEEIQR 92
Cdd:COG3432     1 MKRRSRLEIIADILEALKNEGAKKTRIMYKANLSYDRLKKYLDLLEEKGLIEKEDdGGRRIYRITEKGREFLEKYEEIKE 80


                  ...
gi 2726455299  93 AMN 95
Cdd:COG3432    81 LLE 83
 
Name Accession Description Interval E-value
COG3432 COG3432
Predicted transcriptional regulator [Transcription];
14-95 1.71e-20

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442658 [Multi-domain]  Cd Length: 83  Bit Score: 77.99  E-value: 1.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2726455299  14 RRKRSSLEIKFDVLKVISLGVDGPTRIMYASNTSWKVLKGILEDLLKKELIVEVG-GIQKRYRLTEKGKELLRKYEEIQR 92
Cdd:COG3432     1 MKRRSRLEIIADILEALKNEGAKKTRIMYKANLSYDRLKKYLDLLEEKGLIEKEDdGGRRIYRITEKGREFLEKYEEIKE 80


                  ...
gi 2726455299  93 AMN 95
Cdd:COG3432    81 LLE 83
HTH_45 pfam14947
Winged helix-turn-helix; This winged helix-turn-helix domain contains an extended C-terminal ...
 16-92 1.22e-17

Winged helix-turn-helix; This winged helix-turn-helix domain contains an extended C-terminal alpha helix which is responsible for dimerization of this domain.


Pssm-ID: 405615 [Multi-domain]  Cd Length: 77  Bit Score: 70.71  E-value: 1.22e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2726455299  16 KRSSLEIKFDVLKVISLGVDGPTRIMYASNTSWKVLKGILEDLLKKELIVEVGGiqkRYRLTEKGKELLRKYEEIQR 92
Cdd:pfam14947   1 RRSKLEIIADILEACSNGGAKKTKIMYNANLSYKLLNKYLDMLVDNGLIKNDGG---KYVLTEKGLELLEKLREFRE 74
WH_MUS81 cd21036
winged helix domain found in crossover junction endonuclease MUS81 and similar proteins; MUS81 ...
 58-86 5.18e-04

winged helix domain found in crossover junction endonuclease MUS81 and similar proteins; MUS81 is a crossover junction endonuclease that interacts with EME1 (essential meiotic structure-specific endonuclease 1) and EME2, to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. The MUS80-EME1 endonuclease maintains genomic integrity in metazoans by cleaving branched DNA structures that can form during mitosis and fission yeast meiosis, and during processing of damaged replication folks. This model corresponds to the winged helix (WH) domain of MUS81, which is responsible for DNA binding. It comprises four helices and two beta strands.


Pssm-ID: 411029  Cd Length: 94  Bit Score: 35.97  E-value: 5.18e-04
                          10        20
                  ....*....|....*....|....*....
gi 2726455299  58 LLKKELIVEVGGIqKRYRLTEKGKELLRK 86
Cdd:cd21036    63 LIKKGLVYKEGRP-ARYSLTEEGRELAEK 90
 
Name Accession Description Interval E-value
COG3432 COG3432
Predicted transcriptional regulator [Transcription];
14-95 1.71e-20

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442658 [Multi-domain]  Cd Length: 83  Bit Score: 77.99  E-value: 1.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2726455299  14 RRKRSSLEIKFDVLKVISLGVDGPTRIMYASNTSWKVLKGILEDLLKKELIVEVG-GIQKRYRLTEKGKELLRKYEEIQR 92
Cdd:COG3432     1 MKRRSRLEIIADILEALKNEGAKKTRIMYKANLSYDRLKKYLDLLEEKGLIEKEDdGGRRIYRITEKGREFLEKYEEIKE 80


                  ...
gi 2726455299  93 AMN 95
Cdd:COG3432    81 LLE 83
HTH_45 pfam14947
Winged helix-turn-helix; This winged helix-turn-helix domain contains an extended C-terminal ...
 16-92 1.22e-17

Winged helix-turn-helix; This winged helix-turn-helix domain contains an extended C-terminal alpha helix which is responsible for dimerization of this domain.


Pssm-ID: 405615 [Multi-domain]  Cd Length: 77  Bit Score: 70.71  E-value: 1.22e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2726455299  16 KRSSLEIKFDVLKVISLGVDGPTRIMYASNTSWKVLKGILEDLLKKELIVEVGGiqkRYRLTEKGKELLRKYEEIQR 92
Cdd:pfam14947   1 RRSKLEIIADILEACSNGGAKKTKIMYNANLSYKLLNKYLDMLVDNGLIKNDGG---KYVLTEKGLELLEKLREFRE 74
WH_MUS81 cd21036
winged helix domain found in crossover junction endonuclease MUS81 and similar proteins; MUS81 ...
 58-86 5.18e-04

winged helix domain found in crossover junction endonuclease MUS81 and similar proteins; MUS81 is a crossover junction endonuclease that interacts with EME1 (essential meiotic structure-specific endonuclease 1) and EME2, to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. The MUS80-EME1 endonuclease maintains genomic integrity in metazoans by cleaving branched DNA structures that can form during mitosis and fission yeast meiosis, and during processing of damaged replication folks. This model corresponds to the winged helix (WH) domain of MUS81, which is responsible for DNA binding. It comprises four helices and two beta strands.


Pssm-ID: 411029  Cd Length: 94  Bit Score: 35.97  E-value: 5.18e-04
                          10        20
                  ....*....|....*....|....*....
gi 2726455299  58 LLKKELIVEVGGIqKRYRLTEKGKELLRK 86
Cdd:cd21036    63 LIKKGLVYKEGRP-ARYSLTEEGRELAEK 90
DUF3116 pfam11313
Protein of unknown function (DUF3116); This family of proteins with unknown function appears ...
 66-86 4.21e-03

Protein of unknown function (DUF3116); This family of proteins with unknown function appears to be restricted to Bacillales.


Pssm-ID: 402765  Cd Length: 84  Bit Score: 33.43  E-value: 4.21e-03
                          10        20
                  ....*....|....*....|.
gi 2726455299  66 EVGGIQKRYRLTEKGKELLRK 86
Cdd:pfam11313  61 ENSNNKKRYRLTEKGKLLYRK 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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