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Conserved domains on  [gi|2730834585|ref|WP_344951786|]
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ATP-binding protein [Actinomadura miaoliensis]

Protein Classification

sensor histidine kinase( domain architecture ID 11454343)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0007165|GO:0004673|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
187-381 3.12e-22

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


:

Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 95.74  E-value: 3.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 187 IGLLDELEARVE--DPELLKGLFTVDHLATRMRRQSESLAVLGGASSRRQ--WTRPVDMYEVLRSSVAEV-----EQYPR 257
Cdd:COG2205    35 LGAAELLLDEEDlsPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLslELEPVDLAELLEEAVEELrplaeEKGIR 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 258 VKV-VPPVLGALRGDAVAdVIHLVAELIENATRFSPPHTHVLLRTERVTAGLAVEVEDRGLGMAAAEQRRMNELLAdpdR 336
Cdd:COG2205   115 LELdLPPELPLVYADPEL-LEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVSDNGPGIPEEELERIFERFY---R 190

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2730834585 337 VSVDELLRDGRIGLFVVAALARRHGVRVRLRSNVFGGTQAVAVLP 381
Cdd:COG2205   191 GDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 433-559 1.04e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585  433 PRYSSPTRETAREVPAVPvahaggpgAETASGGAGAAPPDVPHRPSAAdsaSPAPPVDHAERPPLPAREAQTHLAPQLRE 512
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAP--------PQSARPRAPVDDRGDPRGPAPP---SPLPPDTHAPDPPPPSPSPAANEPDPHPP 2643

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2730834585  513 APAPRREEDGPLHSPGLmaafrggVRRAEREDGGHDPGAPAGPPGTP 559
Cdd:PHA03247  2644 PTVPPPERPRDDPAPGR-------VSRPRRARRLGRAAQASSPPQRP 2683
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
187-381 3.12e-22

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 95.74  E-value: 3.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 187 IGLLDELEARVE--DPELLKGLFTVDHLATRMRRQSESLAVLGGASSRRQ--WTRPVDMYEVLRSSVAEV-----EQYPR 257
Cdd:COG2205    35 LGAAELLLDEEDlsPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLslELEPVDLAELLEEAVEELrplaeEKGIR 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 258 VKV-VPPVLGALRGDAVAdVIHLVAELIENATRFSPPHTHVLLRTERVTAGLAVEVEDRGLGMAAAEQRRMNELLAdpdR 336
Cdd:COG2205   115 LELdLPPELPLVYADPEL-LEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVSDNGPGIPEEELERIFERFY---R 190

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2730834585 337 VSVDELLRDGRIGLFVVAALARRHGVRVRLRSNVFGGTQAVAVLP 381
Cdd:COG2205   191 GDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 270-381 8.52e-15

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 70.37  E-value: 8.52e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585  270 GDAVAdVIHLVAELIENATRFSPPHTHVLLRTERVTAGLAVEVEDRGLGMAAAEQRRMNELLadpdrVSVDELLRDGR-- 347
Cdd:smart00387   1 GDPDR-LRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPF-----FRTDKRSRKIGgt 74

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2730834585  348 -IGLFVVAALARRHGVRVRLRSNVFGGTQAVAVLP 381
Cdd:smart00387  75 gLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 275-381 2.11e-12

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 63.54  E-value: 2.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 275 DVIHLVAELIENATRFSPPHTHVLLRTERVtAGLAVEVEDRGLGMAAAEQRRMNELLADPDRVSVDEllrdGRIGLFVVA 354
Cdd:pfam02518   5 RLRQVLSNLLDNALKHAAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGG----TGLGLSIVR 79

                          90       100
                  ....*....|....*....|....*..
gi 2730834585 355 ALARRHGVRVRLRSNVFGGTQAVAVLP 381
Cdd:pfam02518  80 KLVELLGGTITVESEPGGGTTVTLTLP 106
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 279-376 2.43e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 46.63  E-value: 2.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 279 LVAELIENATRFSPPHTHVLLRTERvTAGLAVEVEDRGLGMAAAEQRRMNELLADPDRVSvdelLRDGRIGLFVVAALAR 358
Cdd:cd16940    17 LLRNLVDNAVRYSPQGSRVEIKLSA-DDGAVIRVEDNGPGIDEEELEALFERFYRSDGQN----YGGSGLGLSIVKRIVE 91

                          90
                  ....*....|....*...
gi 2730834585 359 RHGVRVRLRSNVFGGTQA 376
Cdd:cd16940    92 LHGGQIFLGNAQGGGLEA 109
PHA03247 PHA03247
large tegument protein UL36; Provisional
 433-559 1.04e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585  433 PRYSSPTRETAREVPAVPvahaggpgAETASGGAGAAPPDVPHRPSAAdsaSPAPPVDHAERPPLPAREAQTHLAPQLRE 512
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAP--------PQSARPRAPVDDRGDPRGPAPP---SPLPPDTHAPDPPPPSPSPAANEPDPHPP 2643

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2730834585  513 APAPRREEDGPLHSPGLmaafrggVRRAEREDGGHDPGAPAGPPGTP 559
Cdd:PHA03247  2644 PTVPPPERPRDDPAPGR-------VSRPRRARRLGRAAQASSPPQRP 2683
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 280-382 1.42e-04

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 44.45  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 280 VAELIENATRFSPPHTHVLLRTERVTAGLAVEVEDRGLGMAAAEQRRMNEL---LADPDrvsvdellrDGR----IGLFV 352
Cdd:PRK11100  373 LGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERfysLPRPA---------NGRkstgLGLAF 443

                          90       100       110
                  ....*....|....*....|....*....|
gi 2730834585 353 VAALARRHGVRVRLRSNVFGGTQAVAVLPN 382
Cdd:PRK11100  444 VREVARLHGGEVTLRNRPEGGVLATLTLPR 473
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
187-381 3.12e-22

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 95.74  E-value: 3.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 187 IGLLDELEARVE--DPELLKGLFTVDHLATRMRRQSESLAVLGGASSRRQ--WTRPVDMYEVLRSSVAEV-----EQYPR 257
Cdd:COG2205    35 LGAAELLLDEEDlsPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLslELEPVDLAELLEEAVEELrplaeEKGIR 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 258 VKV-VPPVLGALRGDAVAdVIHLVAELIENATRFSPPHTHVLLRTERVTAGLAVEVEDRGLGMAAAEQRRMNELLAdpdR 336
Cdd:COG2205   115 LELdLPPELPLVYADPEL-LEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVSDNGPGIPEEELERIFERFY---R 190

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2730834585 337 VSVDELLRDGRIGLFVVAALARRHGVRVRLRSNVFGGTQAVAVLP 381
Cdd:COG2205   191 GDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
60-381 1.84e-16

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 80.72  E-value: 1.84e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585  60 VLAMAGTGTVVLLAATVYGARDAARRVRQRVDALRALSAHGRADLRALMTRLENGERPTPRRVAPPPAEAADADPFTLLA 139
Cdd:COG0642     1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 140 LDLHRERHAAREAVVRAASLTSGTGADRQVEVFV-NVARRMQSLVHREIGLLDELEARVeDPELLKGLFTVDHLATRMRR 218
Cdd:COG0642    81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLaNVSHELRTPLTAIRGYLELLLEEL-DEEQREYLETILRSADRLLR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 219 QSESLAVLG--GASSRRQWTRPVDMYEVLRSSVAEVEQYPRVK------VVPPVLGALRGDAVAdVIHLVAELIENATRF 290
Cdd:COG0642   160 LINDLLDLSrlEAGKLELEPEPVDLAELLEEVVELFRPLAEEKgielelDLPDDLPTVRGDPDR-LRQVLLNLLSNAIKY 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 291 SPPHTHVLLRTERVTAGLAVEVEDRGLGMAAAEQRRMNELLadpdrVSVDELLRDGR--IGLFVVAALARRHGVRVRLRS 368
Cdd:COG0642   239 TPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPF-----FRTDPSRRGGGtgLGLAIVKRIVELHGGTIEVES 313

                         330
                  ....*....|...
gi 2730834585 369 NVFGGTQAVAVLP 381
Cdd:COG0642   314 EPGKGTTFTVTLP 326
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 270-381 8.52e-15

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 70.37  E-value: 8.52e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585  270 GDAVAdVIHLVAELIENATRFSPPHTHVLLRTERVTAGLAVEVEDRGLGMAAAEQRRMNELLadpdrVSVDELLRDGR-- 347
Cdd:smart00387   1 GDPDR-LRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPF-----FRTDKRSRKIGgt 74

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2730834585  348 -IGLFVVAALARRHGVRVRLRSNVFGGTQAVAVLP 381
Cdd:smart00387  75 gLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 275-381 2.11e-12

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 63.54  E-value: 2.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 275 DVIHLVAELIENATRFSPPHTHVLLRTERVtAGLAVEVEDRGLGMAAAEQRRMNELLADPDRVSVDEllrdGRIGLFVVA 354
Cdd:pfam02518   5 RLRQVLSNLLDNALKHAAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGG----TGLGLSIVR 79

                          90       100
                  ....*....|....*....|....*..
gi 2730834585 355 ALARRHGVRVRLRSNVFGGTQAVAVLP 381
Cdd:pfam02518  80 KLVELLGGTITVESEPGGGTTVTLTLP 106
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
193-381 1.56e-09

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 59.95  E-value: 1.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 193 LEARVEDPELLKglftvdHLATRMRRQSESLAVL------------GGASSRRQwtrPVDMYEVLRSSVAEVEQYPRVKV 260
Cdd:COG5002   191 LDGAADDPEERR------EYLEIILEEAERLSRLvndlldlsrlesGELKLEKE---PVDLAELLEEVVEELRPLAEEKG 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 261 V------PPVLGALRGDAvADVIHLVAELIENATRFSPPHTHVLLRTERVTAGLAVEVEDRGLGMAAAEQRRMNELL--A 332
Cdd:COG5002   262 IeleldlPEDPLLVLGDP-DRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFyrV 340

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2730834585 333 DPDRVsvdellRDGR---IGLFVVAALARRHGVRVRLRSNVFGGTQAVAVLP 381
Cdd:COG5002   341 DKSRS------RETGgtgLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLP 386
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 279-376 2.43e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 46.63  E-value: 2.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 279 LVAELIENATRFSPPHTHVLLRTERvTAGLAVEVEDRGLGMAAAEQRRMNELLADPDRVSvdelLRDGRIGLFVVAALAR 358
Cdd:cd16940    17 LLRNLVDNAVRYSPQGSRVEIKLSA-DDGAVIRVEDNGPGIDEEELEALFERFYRSDGQN----YGGSGLGLSIVKRIVE 91

                          90
                  ....*....|....*...
gi 2730834585 359 RHGVRVRLRSNVFGGTQA 376
Cdd:cd16940    92 LHGGQIFLGNAQGGGLEA 109
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 280-380 1.76e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 43.99  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 280 VAELIENATRFSPPHTHVLLRTERVTAGLAVEVEDRGLGMAAAEQRRMNELLADPDRVSVDEllRDGRIGLFVVAALARR 359
Cdd:cd16945     9 INNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQ--KSTGLGLAFVQEVAQL 86

                          90       100
                  ....*....|....*....|.
gi 2730834585 360 HGVRVRLRsNVFGGTQAVAVL 380
Cdd:cd16945    87 HGGRITLR-NRPDGVLAFLTL 106
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 280-384 7.24e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 42.19  E-value: 7.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 280 VAELIENATRFSPPHTHVLLRTERVTAGLAVEVEDRGLGMAAAEQRRMNELLADPDRVSVDELLRDGrIGLFVVAALARR 359
Cdd:cd16952     5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTG-LGLAIVKHVMSR 83

                          90       100
                  ....*....|....*....|....*
gi 2730834585 360 HGVRVRLRSNVFGGTQAVAVLPNEL 384
Cdd:cd16952    84 HDARLLIASELGKGSRFTCLFPSSR 108
PHA03247 PHA03247
large tegument protein UL36; Provisional
 433-559 1.04e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585  433 PRYSSPTRETAREVPAVPvahaggpgAETASGGAGAAPPDVPHRPSAAdsaSPAPPVDHAERPPLPAREAQTHLAPQLRE 512
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAP--------PQSARPRAPVDDRGDPRGPAPP---SPLPPDTHAPDPPPPSPSPAANEPDPHPP 2643

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2730834585  513 APAPRREEDGPLHSPGLmaafrggVRRAEREDGGHDPGAPAGPPGTP 559
Cdd:PHA03247  2644 PTVPPPERPRDDPAPGR-------VSRPRRARRLGRAAQASSPPQRP 2683
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 280-382 1.42e-04

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 44.45  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 280 VAELIENATRFSPPHTHVLLRTERVTAGLAVEVEDRGLGMAAAEQRRMNEL---LADPDrvsvdellrDGR----IGLFV 352
Cdd:PRK11100  373 LGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERfysLPRPA---------NGRkstgLGLAF 443

                          90       100       110
                  ....*....|....*....|....*....|
gi 2730834585 353 VAALARRHGVRVRLRSNVFGGTQAVAVLPN 382
Cdd:PRK11100  444 VREVARLHGGEVTLRNRPEGGVLATLTLPR 473
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 175-381 2.08e-04

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 43.80  E-value: 2.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 175 VARRM-----------QSLVHReigLLDELEARVED--PELLKGLFTVDHLATRMRRQSESLAVLggasSRRQWT--RPV 239
Cdd:COG5000   204 LARRIaheiknpltpiQLSAER---LRRKLADKLEEdrEDLERALDTIIRQVDRLKRIVDEFLDF----ARLPEPqlEPV 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 240 DMYEVLRSSVAEVE---QYPRVKV---VPPVLGALRGDAVA--DVIHlvaELIENATRFSPPHTHVLLRTERVTAGLAVE 311
Cdd:COG5000   277 DLNELLREVLALYEpalKEKDIRLeldLDPDLPEVLADRDQleQVLI---NLLKNAIEAIEEGGEIEVSTRREDGRVRIE 353

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2730834585 312 VEDRGLGMAAAEQRRmnelLADP---DRvsvdellRDGR-IGLFVVAALARRHGVRVRLRSNVFGGTQAVAVLP 381
Cdd:COG5000   354 VSDNGPGIPEEVLER----IFEPfftTK-------PKGTgLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLP 416
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 279-381 2.29e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 40.51  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 279 LVAELIENATRFSppHTHVLLRTERVTAGLAVEVEDRGLGMAAAEqrrMNELLADPDRVSVDELLRDGRIGLFVVAALAR 358
Cdd:cd16950     4 VLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEE---VDELFQPFYRGDNARGTSGTGLGLAIVQRISD 78

                          90       100
                  ....*....|....*....|...
gi 2730834585 359 RHGVRVRLRSNVFGGTQAVAVLP 381
Cdd:cd16950    79 AHGGSLTLANRAGGGLCARIELP 101
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 276-381 3.38e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 39.96  E-value: 3.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 276 VIHLVAELIENA------TRFSPPHTHVLLRTErvTAGLAVEVEDRGLGMAAAEQRRMNElladpDRVSVDELLRDGrIG 349
Cdd:cd16915     1 LITIVGNLIDNAldalaaTGAPNKQVEVFLRDE--GDDLVIEVRDTGPGIAPELRDKVFE-----RGVSTKGQGERG-IG 72

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2730834585 350 LFVVAALARRHGVRVRLRSNVFGGTQAVAVLP 381
Cdd:cd16915    73 LALVRQSVERLGGSITVESEPGGGTTFSIRIP 104
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 352-560 3.51e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 3.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 352 VVAALARRHGVRVRLRSNVfgGTQAVAVLPNELVASAPRETPAAIPAPAPTPTPTPTPAPAPPAGAPGAPPAPAPAARPV 431
Cdd:PRK07764  570 LVTALAEELGGDWQVEAVV--GPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGV 647

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 432 EPRYSSPTRETAREVPAVPVAHAGGPGAETASGGAGAAPPDVPHRPSAADSASPAPPVDHAERP-PLPAREAQTHLAPQL 510
Cdd:PRK07764  648 AAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAgQADDPAAQPPQAAQG 727

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2730834585 511 REAPAPRREEDGPLHS-PGLMAAFRGGVRRAEREDGGHDPGAPAGPPGTPS 560
Cdd:PRK07764  728 ASAPSPAADDPVPLPPePDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSP 778
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 272-383 4.74e-04

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 42.53  E-value: 4.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 272 AVADVIHLVAELIENA----TRFSPPHTHVLLRTERVTAGLAVEVEDRGLGMAAAEQRRMNElladpDRVSVDEllRDGR 347
Cdd:COG3290   278 SDTDLVTILGNLLDNAieavEKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFE-----RGFSTKL--GEGR 350

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2730834585 348 -IGLFVVAALARRHGVRVRLRSNVFGGTQAVAVLPNE 383
Cdd:COG3290   351 gLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKE 387
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 189-381 6.44e-04

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 42.09  E-value: 6.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 189 LLDELEARVEDPELLKGLFTVDHLATRMRRQSESL-AVLGGASSRRQwtrPVDMYEVLRSSVAEVEQ---YPRVKVV--- 261
Cdd:COG4191   167 LRRRLEDEPDPEELREALERILEGAERAAEIVRSLrAFSRRDEEERE---PVDLNELIDEALELLRPrlkARGIEVEldl 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 262 PPVLGALRGDAVAdVIHLVAELIENA-----TRFSPphtHVLLRTERVTAGLAVEVEDRGLGMAAAEQRRmnelLADP-- 334
Cdd:COG4191   244 PPDLPPVLGDPGQ-LEQVLLNLLINAidameEGEGG---RITISTRREGDYVVISVRDNGPGIPPEVLER----IFEPff 315

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2730834585 335 --DRVsvdellrdGR---IGLFVVAALARRHGVRVRLRSNVFGGTQAVAVLP 381
Cdd:COG4191   316 ttKPV--------GKgtgLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 461-560 4.08e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 461 TASGGAGAAPPDVPHRPSAADSASPAPPVDHAERPPLPAREA--QTHLAPQLREAPAPRREEDGPLHSPGLMAAFRGGVR 538
Cdd:PRK07764  386 GVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAapQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQ 465

                          90       100
                  ....*....|....*....|..
gi 2730834585 539 RAEREDGGHDPGAPAGPPGTPS 560
Cdd:PRK07764  466 PAPAPAAAPEPTAAPAPAPPAA 487
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
386-556 9.25e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 38.70  E-value: 9.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 386 ASAPRETPAAIPAPAPTPTPTPTPAPAPPAGAPGAPPAPAPAARPVEPRYSSPTRETAREVPAVPVAHAGGPGAETASGG 465
Cdd:PRK12323  394 AAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVA 473

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585 466 AGAAPPDVPHRPSAADSASPAPPVDHAERPPLPAREA--QTHLAPQLREAPAPRREEDGPLHSPGLMAAFRGGVRRAERE 543
Cdd:PRK12323  474 AAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPApaQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRA 553

                         170
                  ....*....|...
gi 2730834585 544 DGGHDPGAPAGPP 556
Cdd:PRK12323  554 AAATEPVVAPRPP 566
PHA03247 PHA03247
large tegument protein UL36; Provisional
 426-559 9.53e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.15  E-value: 9.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730834585  426 PAARPVEPRYSSPTRETA--REVPAVPVAHAGGPGAETASGGAGAAPPDVPHRPSAAdsASPAPPVDHAERPPLPA-REA 502
Cdd:PHA03247  2710 PAPHALVSATPLPPGPAAarQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP--PAPAPPAAPAAGPPRRLtRPA 2787

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2730834585  503 QTHLAPQLREAPAPRREEDGPLHSPGLMAAFRGGVRRAERE--DGGHDPGAPAGPPGTP 559
Cdd:PHA03247  2788 VASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLppPTSAQPTAPPPPPGPP 2846
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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