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Conserved domains on  [gi|2735597269|ref|WP_346843507|]
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response regulator transcription factor [Rothia amarae]

Protein Classification

winged helix-turn-helix domain-containing protein( domain architecture ID 10086760)

winged helix-turn-helix (wHTH) domain-containing protein binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0006355
PubMed:  9199401|11934608|10679470|10473770|15808743
SCOP:  3001179

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 130-217 1.35e-36

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


:

Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 123.74  E-value: 1.35e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269 130 ILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKLGTEHEH-LIS 208
Cdd:cd00383     1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEDDPEPrLIK 80


                  ....*....
gi 2735597269 209 TVRNVGYSL 217
Cdd:cd00383    81 TVRGVGYRL 89
 
Name Accession Description Interval E-value
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 130-217 1.35e-36

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 123.74  E-value: 1.35e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269 130 ILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKLGTEHEH-LIS 208
Cdd:cd00383     1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEDDPEPrLIK 80


                  ....*....
gi 2735597269 209 TVRNVGYSL 217
Cdd:cd00383    81 TVRGVGYRL 89
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
143-217 1.02e-32

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 113.38  E-value: 1.02e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2735597269 143 GLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKLG--TEHEHLISTVRNVGYSL 217
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLEddPRDPRLIKTVRGVGYRL 77
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 92-218 1.51e-31

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 115.12  E-value: 1.51e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  92 VDDIVFEAAGPAELEARLCMLPSAPTESQQETTIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQ 171
Cdd:TIGR02154  99 ADDYITKPFSPRELLARIKAVLRRIRPQLSDEVIEVGDLSLDPVAHRVFRGGQPLSLGPTEFRLLHFFMTHPERVYSREQ 178

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2735597269 172 LLSEVWGHDYFGGTRTVDVHVRRLRAKLGTE-HEHLISTVRNVGYSLD 218
Cdd:TIGR02154 179 LLDRVWGRDVYVEERTVDVHIRRLRKALNPFgLEDPVQTVRGAGYRFS 226
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 143-217 4.02e-30

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 106.87  E-value: 4.02e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2735597269  143 GLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKLGTEHEH-LISTVRNVGYSL 217
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLEDDGDPrLIETVRGVGYRL 76
resp_reg_YycF NF040534
response regulator YycF;
93-217 9.37e-29

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 107.88  E-value: 9.37e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  93 DDIVFEAAGPAELEARL------CMLPSAPTESQQETTIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRV 166
Cdd:NF040534   95 DDYVTKPFSTRELIARVkanlrrHQQQNTEEEEEENNEIVIGSLTIHPDAYTVKKRGETIELTHREFELLHYLAKHIGQV 174

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2735597269 167 FTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKLGTEHEH--LISTVRNVGYSL 217
Cdd:NF040534  175 MTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHpeWIVTRRGVGYYL 227
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 62-203 2.30e-27

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 103.50  E-value: 2.30e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  62 AQLIRAALPDLPLLMV--LSEGGFAAVSPTWLVDDIV---FEaagPAELEARLCMLpsapTESQQETTIRCGAiLIDEAS 136
Cdd:COG0745    64 CRRLRARPSDIPIIMLtaRDDEEDRVRGLEAGADDYLtkpFD---PEELLARIRAL----LRRRAAEVLRVGD-LLDLAA 135

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2735597269 137 YTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYfGGTRTVDVHVRRLRAKLGTEH 203
Cdd:COG0745   136 REVTRDGEPVELTPKEFRLLELLMRNPGRVVSREQLLEEVWGYDY-GDDRTVDVHISRLRKKLEDDL 201
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
93-215 4.05e-27

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 103.41  E-value: 4.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  93 DDIVFEAAGPAELEARLcmlpSA---PTESQQETTIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTR 169
Cdd:NF040689   93 DDYVVKPFKPKELVARI----RArlrRSEDEESEVLRIGDLTIDVAGHEVTRGGEEIPLTPLEFDLLVALARKPGQVFSR 168

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2735597269 170 AQLLSEVWGHDYFGGTRTVDVHVRRLRAKLGT--EHEHLISTVRNVGY 215
Cdd:NF040689  169 EELLEQVWGYRHAADTRLVNVHVQRLRAKIERdpENPEIVVTVRGVGY 216
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
55-219 6.12e-22

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 90.16  E-value: 6.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  55 LMEARNGAQLIR-----AALPDLPLLMVLSEG-------GFAAVSptwlvDDIVFEAAGPAELEARLCMLPSAPTESQQE 122
Cdd:PRK10161   55 MLPGGSGIQFIKhlkreSMTRDIPVVMLTARGeeedrvrGLETGA-----DDYITKPFSPKELVARIKAVMRRISPMAVE 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269 123 TTIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKL-GT 201
Cdd:PRK10161  130 EVIEMQGLSLDPTSHRVMAGEEPLEMGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALePG 209

                         170
                  ....*....|....*...
gi 2735597269 202 EHEHLISTVRNVGYSLDT 219
Cdd:PRK10161  210 GHDRMVQTVRGTGYRFST 227
 
Name Accession Description Interval E-value
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 130-217 1.35e-36

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 123.74  E-value: 1.35e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269 130 ILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKLGTEHEH-LIS 208
Cdd:cd00383     1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEDDPEPrLIK 80


                  ....*....
gi 2735597269 209 TVRNVGYSL 217
Cdd:cd00383    81 TVRGVGYRL 89
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
143-217 1.02e-32

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 113.38  E-value: 1.02e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2735597269 143 GLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKLG--TEHEHLISTVRNVGYSL 217
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLEddPRDPRLIKTVRGVGYRL 77
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 92-218 1.51e-31

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 115.12  E-value: 1.51e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  92 VDDIVFEAAGPAELEARLCMLPSAPTESQQETTIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQ 171
Cdd:TIGR02154  99 ADDYITKPFSPRELLARIKAVLRRIRPQLSDEVIEVGDLSLDPVAHRVFRGGQPLSLGPTEFRLLHFFMTHPERVYSREQ 178

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2735597269 172 LLSEVWGHDYFGGTRTVDVHVRRLRAKLGTE-HEHLISTVRNVGYSLD 218
Cdd:TIGR02154 179 LLDRVWGRDVYVEERTVDVHIRRLRKALNPFgLEDPVQTVRGAGYRFS 226
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 143-217 4.02e-30

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 106.87  E-value: 4.02e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2735597269  143 GLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKLGTEHEH-LISTVRNVGYSL 217
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLEDDGDPrLIETVRGVGYRL 76
resp_reg_YycF NF040534
response regulator YycF;
93-217 9.37e-29

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 107.88  E-value: 9.37e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  93 DDIVFEAAGPAELEARL------CMLPSAPTESQQETTIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRV 166
Cdd:NF040534   95 DDYVTKPFSTRELIARVkanlrrHQQQNTEEEEEENNEIVIGSLTIHPDAYTVKKRGETIELTHREFELLHYLAKHIGQV 174

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2735597269 167 FTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKLGTEHEH--LISTVRNVGYSL 217
Cdd:NF040534  175 MTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHpeWIVTRRGVGYYL 227
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 62-203 2.30e-27

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 103.50  E-value: 2.30e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  62 AQLIRAALPDLPLLMV--LSEGGFAAVSPTWLVDDIV---FEaagPAELEARLCMLpsapTESQQETTIRCGAiLIDEAS 136
Cdd:COG0745    64 CRRLRARPSDIPIIMLtaRDDEEDRVRGLEAGADDYLtkpFD---PEELLARIRAL----LRRRAAEVLRVGD-LLDLAA 135

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2735597269 137 YTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYfGGTRTVDVHVRRLRAKLGTEH 203
Cdd:COG0745   136 REVTRDGEPVELTPKEFRLLELLMRNPGRVVSREQLLEEVWGYDY-GDDRTVDVHISRLRKKLEDDL 201
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
93-215 4.05e-27

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 103.41  E-value: 4.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  93 DDIVFEAAGPAELEARLcmlpSA---PTESQQETTIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTR 169
Cdd:NF040689   93 DDYVVKPFKPKELVARI----RArlrRSEDEESEVLRIGDLTIDVAGHEVTRGGEEIPLTPLEFDLLVALARKPGQVFSR 168

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2735597269 170 AQLLSEVWGHDYFGGTRTVDVHVRRLRAKLGT--EHEHLISTVRNVGY 215
Cdd:NF040689  169 EELLEQVWGYRHAADTRLVNVHVQRLRAKIERdpENPEIVVTVRGVGY 216
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
55-219 6.12e-22

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 90.16  E-value: 6.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  55 LMEARNGAQLIR-----AALPDLPLLMVLSEG-------GFAAVSptwlvDDIVFEAAGPAELEARLCMLPSAPTESQQE 122
Cdd:PRK10161   55 MLPGGSGIQFIKhlkreSMTRDIPVVMLTARGeeedrvrGLETGA-----DDYITKPFSPKELVARIKAVMRRISPMAVE 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269 123 TTIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKL-GT 201
Cdd:PRK10161  130 EVIEMQGLSLDPTSHRVMAGEEPLEMGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALePG 209

                         170
                  ....*....|....*...
gi 2735597269 202 EHEHLISTVRNVGYSLDT 219
Cdd:PRK10161  210 GHDRMVQTVRGTGYRFST 227
orf27 CHL00148
Ycf27; Reviewed
 93-215 4.43e-21

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 87.85  E-value: 4.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  93 DDIVFEAAGPAELEAR-LCML-----PSAPTESQQETTIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRV 166
Cdd:CHL00148  101 DDYVVKPFSPKELEARiRSVLrrtnkKSFSSKIPNSSIIRIGFLKIDLNKKQVYKNNERIRLTGMEFSLLELLISKSGEI 180

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2735597269 167 FTRAQLLSEVWGHDY--FGGTRTVDVHVRRLRAKLGTE--HEHLISTVRNVGY 215
Cdd:CHL00148  181 FSRATILKEVWGYTPerHIDTRVVDVHISRLRAKLEDDpsNPDLILTARGTGY 233
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 93-217 7.40e-19

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 81.55  E-value: 7.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  93 DDIVFEAAGPAELEARL-CMLPSAPTESQQETTIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQ 171
Cdd:PRK11083   99 DDYVAKPFSPREVAARVrTILRRVKKFAAPSPVIRIGHFELDEPAARISYFGTPLTLTRYEFLLLKTLLLSPGRVFSRQQ 178

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2735597269 172 LLSEVWGHDYFGGTRTVDVHVRRLRAKLGT--EHEHLISTVRNVGYSL 217
Cdd:PRK11083  179 LMDIVWEDAQDSYDRTVDTHIKTLRAKLRAinPDLSPINTHRGMGYSL 226
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
123-218 1.41e-18

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 77.64  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269 123 TTIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGhDYFGGTRTVDVHVRRLRAKLG-- 200
Cdd:COG3710     1 MRYRFGDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWP-GRVVSDNSLTQAISRLRKALGdd 79

                          90
                  ....*....|....*...
gi 2735597269 201 TEHEHLISTVRNVGYSLD 218
Cdd:COG3710    80 GLEPRLIRTVPRRGYRLV 97
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 63-218 7.27e-17

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 76.50  E-value: 7.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  63 QLIRAALPDLPLLMVLSEG-------GFAAVSPTWLVDDIVFeaagpAELEARLCMLPSAPTESQQETTIRCGAILIDEA 135
Cdd:PRK09836   64 RMLRSANKGMPILLLTALGtiehrvkGLELGADDYLVKPFAF-----AELLARVRTLLRRGAAVIIESQFQVADLMVDLV 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269 136 SYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKLGTEHE-HLISTVRNVG 214
Cdd:PRK09836  139 SRKVTRSGTRITLTSKEFTLLEFFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRGKIDNDFEpKLIQTVRGVG 218


                  ....
gi 2735597269 215 YSLD 218
Cdd:PRK09836  219 YMLE 222
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 93-215 1.08e-16

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 76.26  E-value: 1.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  93 DDIVFEAAGPAELEARL------CMLPSAPTESQQETtircgAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRV 166
Cdd:PRK10710  105 DDYICKPYSPREVVARVktilrrCKPQRELQQQDAES-----PLIIDESRFQASWRGKMLDLTPAEFRLLKTLSHEPGKV 179

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2735597269 167 FTRAQLLSEVWgHDYFGGT-RTVDVHVRRLRAKLGT--EHEHLISTVRNVGY 215
Cdd:PRK10710  180 FSREQLLNHLY-DDYRVVTdRTIDSHIKNLRRKLESldAEQSFIRAVYGVGY 230
PRK11517 PRK11517
DNA-binding response regulator HprR;
123-217 1.41e-14

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 69.93  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269 123 TTIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKLGTE 202
Cdd:PRK11517  123 STLEISGLRMDSVSQSVSRDNISITLTRKEFQLLWLLASRAGEIIPRTVIASEIWGINFDSDTNTVDVAIRRLRAKVDDP 202

                          90
                  ....*....|....*.
gi 2735597269 203 HE-HLISTVRNVGYSL 217
Cdd:PRK11517  203 FPeKLIATIRGMGYSF 218
PRK10336 PRK10336
two-component system response regulator QseB;
93-217 3.74e-12

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 63.38  E-value: 3.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  93 DDIVFEAAGPAELEARLCMLPSApTESQQETTIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQL 172
Cdd:PRK10336   96 DDYLCKPFALIEVAARLEALMRR-TNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLELLMRNAGRVLPRKLI 174

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2735597269 173 LSEVWGHDYFGGTRTVDVHVRRLRAKLGTeheHLISTVRNVGYSL 217
Cdd:PRK10336  175 EEKLYTWDEEVTSNAVEVHVHHLRRKLGS---DFIRTVHGIGYTL 216
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 93-215 8.61e-10

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 56.95  E-value: 8.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  93 DDIVFEAAGPAELEARL------CMLPSAPTESQQET-----TIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQ 161
Cdd:PRK10701   96 CDYILKTTPPAVLLARLrlhlrqNEQATQTKGLQETSltpykALHFGTLTIDPVNRQVTLAGEEISLSTADFDLLWELAT 175

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2735597269 162 NPSRVFTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKLG--TEHEHLISTVRNVGY 215
Cdd:PRK10701  176 HAGQIMDRDALLKNLRGVSYDGLDRSVDVAISRLRKKLLdnAAEPYRIKTVRNKGY 231
PRK10766 PRK10766
two-component system response regulator TorR;
113-202 8.65e-10

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 56.59  E-value: 8.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269 113 PSAPTESQQETTIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYFGGTRTVDVHV 192
Cdd:PRK10766  125 QAQPHAQEEDNCYRFAGYCLNVSRRTLERNGEPIKLTKAEYELLVAFVTNPGQVLSRERLLRMLSHRVENPNDRTIDVLI 204

                          90
                  ....*....|
gi 2735597269 193 RRLRAKLGTE 202
Cdd:PRK10766  205 RRLRHKLNPD 214
ompR PRK09468
osmolarity response regulator; Provisional
 65-215 1.88e-09

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 56.14  E-value: 1.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  65 IRAALPDLPLLMVLSEGGfaavsptwLVDDIVFEAAG----------PAELEARL--------CMLPSAPteSQQETTIR 126
Cdd:PRK09468   71 LRSQNNPTPIIMLTAKGE--------EVDRIVGLEIGaddylpkpfnPRELLARIravlrrqaPELPGAP--SQEEEVIA 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269 127 CGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYFGGTRTVDVHVRRLRaKLGTE---H 203
Cdd:PRK09468  141 FGKFKLNLGTRELFRGDEPMPLTTGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLR-RLIEEdpaH 219

                         170
                  ....*....|..
gi 2735597269 204 EHLISTVRNVGY 215
Cdd:PRK09468  220 PRYIQTVWGLGY 231
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 93-215 3.98e-09

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 54.81  E-value: 3.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269  93 DDIVFEAAGPAELEARL-CMLPSAPTESQQETTIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQ 171
Cdd:PRK10529   96 DDYLSKPFGIGELQARLrVALRRHSATPAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLLAVLLNNAGKVLTQRQ 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2735597269 172 LLSEVWGHDYFGGTRTVDVHVRRLRAKLGTE---HEHLIsTVRNVGY 215
Cdd:PRK10529  176 LLNQVWGPNAVEHSHYLRIYMGHLRQKLEQDparPRHFI-TETGIGY 221
PRK11173 PRK11173
two-component response regulator; Provisional
 152-215 1.39e-07

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 50.40  E-value: 1.39e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2735597269 152 EFELLKFFAQNPSRVFTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKLGTEHE--HLISTVRNVGY 215
Cdd:PRK11173  165 EFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDtpEIIATIHGEGY 230
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
104-215 1.57e-07

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 50.57  E-value: 1.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269 104 ELEARL--CMLPSAPTESQQET-----TIRCGAILIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEV 176
Cdd:PRK10955  106 ELVARIraILRRSHWSEQQQNNdngspTLEVDALSLNPGRQEASFDGQTLELTGTEFTLLYLLAQHLGQVVSREHLSQEV 185

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2735597269 177 WGHDYFGGTRTVDVHVRRLRAKLGTEHEHL--ISTVRNVGY 215
Cdd:PRK10955  186 LGKRLTPFDRAIDMHISNLRRKLPDRKDGHpwFKTLRGRGY 226
PRK10643 PRK10643
two-component system response regulator PmrA;
103-221 8.24e-07

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 48.11  E-value: 8.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269 103 AELEARLCMLPSApTESQQETTIRCGAILIDEASYTARINGLPLNLTYKEFELLkffaqnpSRVFTRA--QLLSEVWGHD 180
Cdd:PRK10643  106 EELHARIRALIRR-HQGQGENELQVGNLTLNLGRQQVWLDGQELILTPKEFALL-------SRLMLKAgsPVHREILYQD 177

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2735597269 181 YFG-----GTRTVDVHVRRLRAKLGTEHehlISTVRNVGYSLDTSR 221
Cdd:PRK10643  178 IYNwddepSSNTLEVHIHNLRDKVGKDR---IRTVRGFGYMLVANE 220
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 146-218 1.27e-06

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 47.89  E-value: 1.27e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2735597269 146 LNLTYKEFELLKFFAQNPSRVFTRAQLL--SEVWGHDYFggTRTVDVHVRRLRAKLGTE--HEHLISTVRNVGYSLD 218
Cdd:PRK13856  154 VKLTAGEFNLLVAFLEKPRDVLSREQLLiaSRVREEEVY--DRSIDVLILRLRRKLEQDpaNPQLIKTARGAGYFFD 228
PRK15479 PRK15479
transcriptional regulator TctD;
103-220 2.30e-06

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 47.02  E-value: 2.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269 103 AELEARLCMLPSApTESQQETTIRCGAILIDEASYTArINGLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYF 182
Cdd:PRK15479  106 EELDARLRALLRR-SAGQVQEVQQLGELIFHDEGYFL-LQGQPLALTPREQALLTVLMYRRTRPVSRQQLFEQVFSLNDE 183

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2735597269 183 GGTRTVDVHVRRLRAKLGTEHEHlISTVRNVGYSLDTS 220
Cdd:PRK15479  184 VSPESIELYIHRLRKKLQGSDVR-ITTLRGLGYVLERG 220
PRK10816 PRK10816
two-component system response regulator PhoP;
131-218 2.83e-04

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 40.88  E-value: 2.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735597269 131 LIDEASYTARINGLPLNLTYKEFELLKFFAQNPSRVFTRAQLLSEVWGHDYFGGTRTVDVHVRRLRAKLGTEHEH-LIST 209
Cdd:PRK10816  133 QVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQeVITT 212


                  ....*....
gi 2735597269 210 VRNVGYSLD 218
Cdd:PRK10816  213 VRGQGYRFD 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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