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Conserved domains on  [gi|2743944752|ref|WP_349680419|]
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MFS transporter, partial [Hyphomonas sp. UBA4508]

Protein Classification

CynX/NimT family MFS transporter( domain architecture ID 11457981)

CynX/NimT family major facilitator superfamily (MFS) transporter similar to cyanate transport protein CynX that is part of a system that transports exogenous cyanate into cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
2-279 2.88e-28

Cyanate permease [Inorganic ion transport and metabolism];


:

Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 111.50  E-value: 2.88e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   2 YRKWIIFAVVVAGFFVLnASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFC 81
Cdd:COG2807    14 AGRWLLLLAIVLVALNL-RPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  82 VALGFGLASASQGLGMFFAAMCLAGAGFSLaGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWR 161
Cdd:COG2807    93 LAAGLLLRSLAPSVALLLAGTALIGAGIAV-GNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 162 FNWMLLAVICGVLILVGGAFITERRDVSGGEArtdnsrgpddakevdgAIPSWRVAIGRPLFLIIAAAITFNLACVTTVH 241
Cdd:COG2807   172 GALAVWALLALLALLLWLPLLRRRPAAAAAAP----------------AAASLRSLWRSPLAWLLTLFFGLQSLLYYAVV 235

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2743944752 242 SIAVSHLKLLGLSPAVGALGLSFMAFVSLAFKGLAGPL 279
Cdd:COG2807   236 AWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLL 273
 
Name Accession Description Interval E-value
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
2-279 2.88e-28

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 111.50  E-value: 2.88e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   2 YRKWIIFAVVVAGFFVLnASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFC 81
Cdd:COG2807    14 AGRWLLLLAIVLVALNL-RPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  82 VALGFGLASASQGLGMFFAAMCLAGAGFSLaGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWR 161
Cdd:COG2807    93 LAAGLLLRSLAPSVALLLAGTALIGAGIAV-GNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 162 FNWMLLAVICGVLILVGGAFITERRDVSGGEArtdnsrgpddakevdgAIPSWRVAIGRPLFLIIAAAITFNLACVTTVH 241
Cdd:COG2807   172 GALAVWALLALLALLLWLPLLRRRPAAAAAAP----------------AAASLRSLWRSPLAWLLTLFFGLQSLLYYAVV 235

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2743944752 242 SIAVSHLKLLGLSPAVGALGLSFMAFVSLAFKGLAGPL 279
Cdd:COG2807   236 AWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLL 273
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 5-279 1.58e-16

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 78.47  E-value: 1.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   5 WIIFAVVVAGFFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVAL 84
Cdd:cd17355     1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  85 GFGLASASQGLGMFFAAMCL-AGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFN 163
Cdd:cd17355    81 GLVLLALATSLWQLYLLWGLlGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 164 WMLLAVICGVLILVGGAFITERRDVSGGEARTDNSRGpddakevdGAIPSWRVAIGRPLFLIIAAAITFNLACVTTVHSI 243
Cdd:cd17355   161 LLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPA--------SPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVH 232

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2743944752 244 AVSHLKLLGLSPAVGALGLSFMAFVSLAFKGLAGPL 279
Cdd:cd17355   233 LVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWL 268
MFS_1 pfam07690
Major Facilitator Superfamily;
11-279 1.93e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 66.29  E-value: 1.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  11 VVAGFFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLAS 90
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  91 ASQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFNWMLLAVI 170
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 171 CGVLILVGGAFITERRDVSGGEARtdnsrgpddaKEVDGAIPSWRVAIGRPLFLIIAAAITFNLACVTTVHSIAVsHLKL 250
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAE----------EARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPL-YQEV 229

                         250       260
                  ....*....|....*....|....*....
gi 2743944752 251 LGLSPAVGALGLSFMAFVSLAFKGLAGPL 279
Cdd:pfam07690 230 LGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
2_A_01_02 TIGR00880
Multidrug resistance protein;
45-184 5.52e-03

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 36.47  E-value: 5.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  45 GLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLASASQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEW 124
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 125 FPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFNWMLLAVICGVLILVGGAFITE 184
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
 
Name Accession Description Interval E-value
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
2-279 2.88e-28

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 111.50  E-value: 2.88e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   2 YRKWIIFAVVVAGFFVLnASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFC 81
Cdd:COG2807    14 AGRWLLLLAIVLVALNL-RPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  82 VALGFGLASASQGLGMFFAAMCLAGAGFSLaGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWR 161
Cdd:COG2807    93 LAAGLLLRSLAPSVALLLAGTALIGAGIAV-GNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 162 FNWMLLAVICGVLILVGGAFITERRDVSGGEArtdnsrgpddakevdgAIPSWRVAIGRPLFLIIAAAITFNLACVTTVH 241
Cdd:COG2807   172 GALAVWALLALLALLLWLPLLRRRPAAAAAAP----------------AAASLRSLWRSPLAWLLTLFFGLQSLLYYAVV 235

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2743944752 242 SIAVSHLKLLGLSPAVGALGLSFMAFVSLAFKGLAGPL 279
Cdd:COG2807   236 AWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLL 273
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 5-279 1.58e-16

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 78.47  E-value: 1.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   5 WIIFAVVVAGFFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVAL 84
Cdd:cd17355     1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  85 GFGLASASQGLGMFFAAMCL-AGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFN 163
Cdd:cd17355    81 GLVLLALATSLWQLYLLWGLlGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 164 WMLLAVICGVLILVGGAFITERRDVSGGEARTDNSRGpddakevdGAIPSWRVAIGRPLFLIIAAAITFNLACVTTVHSI 243
Cdd:cd17355   161 LLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPA--------SPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVH 232

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2743944752 244 AVSHLKLLGLSPAVGALGLSFMAFVSLAFKGLAGPL 279
Cdd:cd17355   233 LVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWL 268
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
3-177 2.47e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 71.82  E-value: 2.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   3 RKWIIFAVVVAGFFvLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCV 82
Cdd:COG2271     7 YRWRILALLFLAYF-LNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  83 ALGFGLASASQGLGMFFAAMCLAGAGFSlAGNVTAVWLIGEWFPEHT-GRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWR 161
Cdd:COG2271    86 GLATLLFGFATSFWQLLLLRFLLGLGEA-GFFPAALKLIAEWFPPKErGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164

                         170
                  ....*....|....*.
gi 2743944752 162 FNWMLLAVICGVLILV 177
Cdd:COG2271   165 AAFLILGLPGLLLALL 180
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-279 1.60e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 69.62  E-value: 1.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   2 YRKWIIFAVVVAGFFVLNASTFAsLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFC 81
Cdd:COG2814     6 RRRWLALLALALGAFLSGLGIGI-VLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  82 VALGFGLASASQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWR 161
Cdd:COG2814    85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 162 FNWMLLAVICGVLILVGGAFITERRDVSGGEARTdnsrgpddakevdgaipSWRVAIGRPLFLIIAAAITFNLACVTTVH 241
Cdd:COG2814   165 WVFLVNAVLALLALLLLLRLLPESRPAARARLRG-----------------SLRELLRRPRLLLLLLLAFLLGFGFFALF 227

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2743944752 242 SIAVSHLK-LLGLSPAVGALGLSFMAFVSLAFKGLAGPL 279
Cdd:COG2814   228 TYLPLYLQeVLGLSASAAGLLLALFGLGGVLGALLAGRL 266
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
3-279 7.31e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 67.98  E-value: 7.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   3 RKWIIFAVVVAGFFvLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCV 82
Cdd:COG2223     2 GRWRVLLLATLAFF-LAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  83 ALGFGLASASQGLGMFFAAMCLAGAGFSlAGNVTAVWLIGEWFP-EHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWR 161
Cdd:COG2223    81 GIGLLLLALAVSYWLLLLLGLLLGIGGG-GSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 162 FNWMLLAVICGVLILVGGAFITERRDVSGGEARTDnsrgpddakevdgaIPSWRVAIGRPLFLIIAAAITFNLACVTTVH 241
Cdd:COG2223   160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS--------------LRDQLEALRDPRFWLLSLLYFGTFGSFIGFS 225

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2743944752 242 SIAVSHLK-LLGLSPAVGALGLSFMAFVSLAFKGLAGPL 279
Cdd:COG2223   226 SWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWL 264
MFS_1 pfam07690
Major Facilitator Superfamily;
11-279 1.93e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 66.29  E-value: 1.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  11 VVAGFFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLAS 90
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  91 ASQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFNWMLLAVI 170
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 171 CGVLILVGGAFITERRDVSGGEARtdnsrgpddaKEVDGAIPSWRVAIGRPLFLIIAAAITFNLACVTTVHSIAVsHLKL 250
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAE----------EARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPL-YQEV 229

                         250       260
                  ....*....|....*....|....*....
gi 2743944752 251 LGLSPAVGALGLSFMAFVSLAFKGLAGPL 279
Cdd:pfam07690 230 LGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
10-279 6.77e-12

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 64.88  E-value: 6.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  10 VVVAGFFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLA 89
Cdd:COG0738    11 IAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  90 SASQGLGMFFAAMCLAGAGFSLAgNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMeWTNWRFNWMLLAV 169
Cdd:COG0738    91 ALAPSYPLLLLALFLLGLGLGLL-DVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLI-LLGLSLSWHLPYL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 170 ICGVLILVGGAFIterrdvsggeARTDNSRGPDDAKEVDGAIPSWRVAIGRPLFLIIAAAITFNLACVTTVHSIAVSHLK 249
Cdd:COG0738   169 ILAVLLLLLALLF----------LRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLK 238

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2743944752 250 -LLGLSPAVGALGLSFMAFVSLAFKGLAGPL 279
Cdd:COG0738   239 dVLGLSEATAALGLSLFWGGMTIGRFLGGFL 269
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 3-277 9.88e-12

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 64.55  E-value: 9.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   3 RKWIIFAVVVAgfFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCV 82
Cdd:cd17353     1 RRWLVLLGAVL--MHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  83 ALGFGLAS-ASQGLGMFFAAMCLAGAGFSLaGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWR 161
Cdd:cd17353    79 GLGFILSAfAISLPLLFLGYGVLGGIGAGI-GYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVP 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 162 FNWMLLAVICGVLILVGGAFITERRDVSGGEARTDNSRGPDDAKEVDGAIPSWRVAIGRPLFLIIAAAITFNLACVTTVH 241
Cdd:cd17353   158 TTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAK 237

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2743944752 242 SIAVShlkLLGLSPAVGALGLSFMAFVSLAFKGLAG 277
Cdd:cd17353   238 PIGQE---FAGLDAGIAALAVSILSIFNGGGRPFWG 270
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
 23-174 1.67e-10

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 60.67  E-value: 1.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  23 FASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLASASqGLGMFFAAM 102
Cdd:cd17339    15 ITSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLG-GIALLFLGT 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2743944752 103 CLAGAGFSLaGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEW--TNWRFN---WMLLAVICGVL 174
Cdd:cd17339    94 ALAGAGIAV-GNVLLPSLIKRDFPRRVGLMTGLYTTSMNLGAALASGLSVPLAQAlgGGWRGAlaiWALPALLALLI 169
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 10-177 5.89e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.05  E-value: 5.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  10 VVVAGFFVLNASTFASLGVVLFVMADDL-GWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGL 88
Cdd:cd17325   202 LALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  89 ASASQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFNWMLLA 168
Cdd:cd17325   282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAA 361


                  ....*....
gi 2743944752 169 VICGVLILV 177
Cdd:cd17325   362 ALLLLAAVL 370
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 31-178 1.37e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 54.89  E-value: 1.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  31 FVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLASASQGLGMFFAAMCLAGAGFS 110
Cdd:cd17473   222 FLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFG 301

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2743944752 111 LAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGD-----IMGPSLSHYMMEWTNWRFNWMLLAVICGVLILVG 178
Cdd:cd17473   302 LLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQflsplVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 12-279 1.83e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 54.74  E-value: 1.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  12 VAGFFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLASA 91
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  92 SQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFNWMLLAVIC 171
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 172 GVLILVGGAFITERrdvsggEARTDNSRGPDDAKEVDGAIPSWRVAIGRPLFLIIAAAITFNLACVTTVHSIAVSHLKLL 251
Cdd:cd06174   161 LALLAAILLLLVVP------DPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG 234

                         250       260
                  ....*....|....*....|....*...
gi 2743944752 252 GLSPAVGALGLSFMAFVSLAFKGLAGPL 279
Cdd:cd06174   235 GLSVAVAGLLLSLFGLAGALGSLLLGLL 262
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
8-143 9.36e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 52.28  E-value: 9.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   8 FAVVVAGFFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFG 87
Cdd:COG2814   209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2743944752  88 LASASQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIG 143
Cdd:COG2814   289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 10-279 4.79e-07

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 50.24  E-value: 4.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  10 VVVAGFFVLNASTFA---SLGVVLFVMADDLGWSYTSAGLsftILGLAVGLTSF---LPAILLQRIGARLTFCFGFFCVA 83
Cdd:cd17352     3 VVVFASFLVNFFTDGilnSFGVLFVELLEEFGESTSDIAW---IGSLLLGVSLFsgpLSSALVNRFGCRPVAIAGGLLAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  84 LGFGLASASQGLGMFFAAM-CLAGAGFSLAGNVTAVwLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRF 162
Cdd:cd17352    80 LGLLLSSFATSLWQLYLTYgVLGGLGLGLIYSPAIV-IVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 163 NWMLLAVICgVLILVGGAFITERRDvsggeartdnsrgpddakevdgaipswrvaigrPLFLIIAAAITFNLACVTTVHS 242
Cdd:cd17352   159 ALLILGGLC-LNLCVCGLLLRLLKD---------------------------------PTFVLLALGVSFAMLGFFVPFV 204

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2743944752 243 IAVSHLKLLGLSPAVGALGLSFMAFVSLAFKGLAGPL 279
Cdd:cd17352   205 YLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLL 241
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 5-186 1.14e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 49.11  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   5 WIIFAVVVAGFfVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVAL 84
Cdd:cd17319     2 WRIIPLLFLAY-VINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  85 GFGLASASQGLGMFFAAMCLAGAGFSlAGNVTAVWLIGEWFP-EHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFN 163
Cdd:cd17319    81 FTALTGFATSLTSLYVLRFLLGVAEA-GFFPGAIKALAEWFPaRERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWA 159

                         170       180
                  ....*....|....*....|...
gi 2743944752 164 WMLLAVIcgVLILVGGAFITERR 186
Cdd:cd17319   160 FIIEGLL--GLLLAVLWWFYLRQ 180
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 10-194 2.49e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.97  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  10 VVVAGFFVlnASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLA 89
Cdd:cd17489     1 ILLANFFF--FLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  90 SASQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFnWMLLAV 169
Cdd:cd17489    79 LLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAV-LFIVAA 157

                         170       180
                  ....*....|....*....|....*
gi 2743944752 170 ICGVLILVGGAFITERRDVSGGEAR 194
Cdd:cd17489   158 VLALLALLLVFLVKDPPPVAAEEAE 182
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 34-279 2.49e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.96  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  34 ADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLASASQGLGMFFAAMCLAGAGFSLAG 113
Cdd:cd17325    23 AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVW 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 114 NVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFnwmlLAVICGVLILVGGAFITERRDVSGGEA 193
Cdd:cd17325   103 PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRA----PFLVCAALALLALVLALLLLPEPRPPP 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 194 RTDNSRGPDDAKevdgaiPSWRVAIGRPLFLIIAAAITFNLACVTTVHSIAVSHLKLLGLSPAVGALGLSFMAFVSLAFK 273
Cdd:cd17325   179 NKRAVSAARLRS------GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQ 252


                  ....*.
gi 2743944752 274 GLAGPL 279
Cdd:cd17325   253 PPAGKL 258
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
5-186 5.21e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.17  E-value: 5.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   5 WIIFAVVVAGFFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVAL 84
Cdd:COG2271   179 LLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLA 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  85 GFGLASASQGLGMFFAAMCLAGAGFSLAGNVTAVW-LIGEWFP-EHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRF 162
Cdd:COG2271   259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWaLAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338

                         170       180
                  ....*....|....*....|....
gi 2743944752 163 NWMLLAVICGVLILVGGAFITERR 186
Cdd:COG2271   339 AFLLLAALALLAALLALLLLRETR 362
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 23-181 9.71e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 46.40  E-value: 9.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  23 FASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLASASQGLGMFFAAM 102
Cdd:cd17321    12 VTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAAR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 103 CLAGAGFSLAGNVTAVwLIGEWFPEH-TGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFNWMLLAVICGVLILVGGAF 181
Cdd:cd17321    92 ALQGIGAAAIMPASLA-LIAATFPGErRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLARTF 170
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
9-178 1.65e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 45.63  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   9 AVVVAGFFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGA-RLTFCFGFFCVALGF- 86
Cdd:COG2807   217 AWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDrRPLLLLLGLLGLAGLl 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  87 GLASASQGLGMFFAAMCLAGAGFSLAgnvTAVWLIGEWF--PEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWT-NWRFN 163
Cdd:COG2807   297 GLLLAPGSLPWLWAVLLGLGQGGLFP---LALTLIGLRArtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATgSWTAA 373

                         170
                  ....*....|....*
gi 2743944752 164 WMLLAVICGVLILVG 178
Cdd:COG2807   374 LLLLAALAVLMLVAG 388
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 20-218 1.96e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 45.31  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  20 ASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLASASQGLGMFF 99
Cdd:cd17475     9 SLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 100 AAMCLAGAGFSLAgNVTAVWLIGEWFPEHT-GRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFNWMLLAVICGVLILVG 178
Cdd:cd17475    89 VLLFLVGAGYGSV-QPGGGRAIMRWFPPRErGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLF 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2743944752 179 GAFITERRDVSGGEARTDNSRGpdDAKEVDGAIPSWRVAI 218
Cdd:cd17475   168 WLFYREPPAASAATESASTLLR--SLKEVLRNRDVWLIAI 205
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 4-177 1.96e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 45.25  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   4 KWIIFAVVVAGFFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQ-RIGARLTFCFGFFCV 82
Cdd:cd17474   196 RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLY 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  83 ALGFGLASASQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRF 162
Cdd:cd17474   276 ALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSA 355

                         170
                  ....*....|....*
gi 2743944752 163 NWMLLAVICGVLILV 177
Cdd:cd17474   356 PFLVGAAIALAAAVL 370
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
5-186 2.22e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.26  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   5 WIIFAVVVAGFFvlnaSTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVAL 84
Cdd:COG2223   208 WLLSLLYFGTFG----SFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  85 G-FGLASASQGLGMFFAAMCLAGAGFSlAGNVTAVWLIGEWFP-EHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRF 162
Cdd:COG2223   284 GlLLLALALGSLWLFLVLFLLLGLALG-GGNGAVFALVPDIFPtKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYT 362

                         170       180
                  ....*....|....*....|....
gi 2743944752 163 NWMLLAVICGVLILVGGAFITERR 186
Cdd:COG2223   363 AAFLVFAVLALVALVLTLLLYRRP 386
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
3-189 2.96e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.84  E-value: 2.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   3 RKWIIFAVVVAGFFVLNASTFASLGVVLFVmaDDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCV 82
Cdd:COG0738   209 NPRLLLGGLAIFLYVGAEGAIGDWLPLYLK--DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLA 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  83 ALGFGLASASQGLGMFFAAMCLAGAGFSLaGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRF 162
Cdd:COG0738   287 AVGLLLALLAPGPWLALIGLALVGLGLSL-MFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRA 365

                         170       180
                  ....*....|....*....|....*..
gi 2743944752 163 nWMLLAVICGVLILVGGAFITERRDVS 189
Cdd:COG0738   366 -AFLVPLVCYLLILLLALALKRKRRKK 391
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 8-112 3.66e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 44.47  E-value: 3.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   8 FAVVVAGFFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFG 87
Cdd:cd17321   170 FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL 249

                          90       100
                  ....*....|....*....|....*...
gi 2743944752  88 L---ASASQGLGMFFAAMCLAGAGFSLA 112
Cdd:cd17321   250 LlalLGADSSVWLLLPGLVLLGLGLGLF 277
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 3-277 6.31e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 43.65  E-value: 6.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   3 RKWIIFAVVVAGFFvLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCV 82
Cdd:COG0477    11 RRRRALLALALGTF-LEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  83 ALGFGLASASQGLGMFFAAMCLAGAGFSLAgNVTAVWLIGEWFPEHT-GRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWR 161
Cdd:COG0477    90 GLASLLCGLAPSPELLIAARALQGIGAGGL-MPGALALIAELFPARErGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 162 FNWMLLAVIcGVLILVGGAFITERRDVSGGEARTDNSRGPDDAKEVDGAIPSWRVAIGRPLFLIIAAAITFNLACVTTVH 241
Cdd:COG0477   169 WIFLINAPL-GLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2743944752 242 SIAVSHLKLLGLSPAVGALGLSFMAFVSLAFKGLAG 277
Cdd:COG0477   248 LALLLLLALLLLAALLLLLLLLLLLALLLALLLLLL 283
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
8-182 1.21e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.97  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   8 FAVVVAGFFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFG 87
Cdd:COG2211   230 FLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  88 LA--SASQGLGMFFAAMCLAGAGFSLAGNVTAVWL-----IGEWFPEH--TGRMIGLYLMLGGIGDIMGPSLSHYMMEWT 158
Cdd:COG2211   310 LLffLGPGNLWLLLVLAALAGIGLGAILVLPWAMLadvvdYDEWKTGRrrEGLYFGIFTFAIKLGQALAGALAGLLLALF 389

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2743944752 159 NWRFN-----------WMLLAVICGVLILVGGAFI 182
Cdd:COG2211   390 GYVAGaaqspsaltgiRLLFFLLPAVLLLLAALLL 424
MFS_1 pfam07690
Major Facilitator Superfamily;
16-148 1.56e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.41  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  16 FVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGAR---LTFCFGFFCVALGFGLASAS 92
Cdd:pfam07690 209 LLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLLLLSLT 288

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2743944752  93 QGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGP 148
Cdd:pfam07690 289 LSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 4-177 1.82e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 42.56  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   4 KWIIFAVVVAGFFVLNastfaSLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVA 83
Cdd:cd17474     1 LYAVFFATLLAVLGVS-----IVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  84 LGFGLASASQGLGMFFAAMCLAGAGFSLAGnVTAVWLIGEWFPEH-TGRMIGLYLMLGGIGDIMGPSLSHYMMEWTnWRF 162
Cdd:cd17474    76 IGGLLCGLSDSFALLLAGRALQGIGAAGLG-PLALTLIGDLFEGGeRAKAMGLYEAALGLGIAVGPLLGGLLAAIS-WRY 153

                         170
                  ....*....|....*
gi 2743944752 163 NWMLLAVICGVLILV 177
Cdd:cd17474   154 PFFLLAALIPVAFLA 168
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 10-177 2.44e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.83  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  10 VVVAGFFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLA 89
Cdd:cd17329     3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  90 SASQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEwTNWRFNWMLLAV 169
Cdd:cd17329    83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAV 161


                  ....*...
gi 2743944752 170 ICGVLILV 177
Cdd:cd17329   162 LFLLAALV 169
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 6-177 2.51e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.83  E-value: 2.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   6 IIFAVVVAGFFVLNASTFASLGVVlfvMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALG 85
Cdd:cd17329   203 LLFLLASFLISLIYFQLESTLPVY---VVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIG 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  86 FGLASASQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFNWM 165
Cdd:cd17329   280 FAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWL 359

                         170
                  ....*....|..
gi 2743944752 166 LLAVICGVLILV 177
Cdd:cd17329   360 ILAALGLIAAAL 371
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 16-177 3.69e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.38  E-value: 3.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  16 FVLNASTFASLGVvLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLASASQGL 95
Cdd:cd17324     9 FAIGTTEYVIQGL-LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  96 GMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFNWMLLAVICGVLI 175
Cdd:cd17324    88 ALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAA 167


                  ..
gi 2743944752 176 LV 177
Cdd:cd17324   168 LL 169
MFS_NIMT_like cd17409
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ...
 21-171 5.28e-04

2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340967 [Multi-domain]  Cd Length: 374  Bit Score: 41.10  E-value: 5.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  21 STFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLASASQGLGMFFA 100
Cdd:cd17409    13 APFTGVAPLLDTIRESFGLSTAQAGLLTTLPLLAFALFSPLAAKLARRYGLERSLFAALLLIAAGIALRSTGSVWALYLG 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2743944752 101 AMCLaGAGFSLaGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFNWMLLAVIC 171
Cdd:cd17409    93 TAII-GAGIAI-GNVLLPSLLKRDFPARVATLTGAYALTMGVGAALGSALVVPLAQVLAFGWQLALGAFLV 161
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 29-178 8.32e-04

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 40.31  E-value: 8.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  29 VLFVMaDDLGWSYTSAGLSFTILGLAVGLT-SFLPAILLQRIGARLTFCFGFFCVALGF-GLASASQGLGMFFAAMCLAG 106
Cdd:cd17388   230 VLFTE-DRFDWSPTMVGLSLAVFGLLHALFqAFVTGPIAKRLGEKRAILLGLAADALGFlLLAFATQGWMVFPILILLAL 308

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2743944752 107 AGfsLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTnwRFNWMLLAVICG-VLILVG 178
Cdd:cd17388   309 GG--IAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAAS--PATWPGLAWIIGaALYLIC 377
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 15-183 1.32e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 39.61  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  15 FFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLASASQG 94
Cdd:cd17333     4 SFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  95 LGMFFAAMCLAGAGFSlAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWrfnWMLLAVICGVL 174
Cdd:cd17333    84 IYLFVVLMFLAGLGAG-ILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELS---WSWAYLIIGLI 159


                  ....*....
gi 2743944752 175 ILVGGAFIT 183
Cdd:cd17333   160 YLLLAILIL 168
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 2-177 1.51e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.52  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   2 YRKWIIFAVVVAGFFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFC 81
Cdd:cd06173   204 LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALL 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  82 VALGFGLASASQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWR 161
Cdd:cd06173   284 LGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363

                         170
                  ....*....|....*.
gi 2743944752 162 FNWMLLAVICGVLILV 177
Cdd:cd06173   364 AVFLLAGALLLLAALL 379
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 38-150 2.38e-03

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 39.12  E-value: 2.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  38 GWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFF---CVALGFGLASASQGLGMFFaAMCLA-----GAGF 109
Cdd:cd17385    30 GVSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFvsgGCTILFGFLDRVPDGTVFI-ALCFLvriveAVGF 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2743944752 110 SLAgnVTAVWLI-GEWFPEHTGRMIGLYLMLGGIGDIMGPSL 150
Cdd:cd17385   109 AAF--ITASFAIiAKEFPNNIATVLGTLETFSGLGLMLGPPL 148
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 9-181 3.20e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 38.34  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   9 AVVVAGFFVLNASTFASLGVVLFVMADDLGWSYtsAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGL 88
Cdd:cd17489   196 VLPPALILFLASIAYGAISTFLPLYAAERGISN--AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLL 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  89 ASASQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRfNWMLLA 168
Cdd:cd17489   274 LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYR-AMFLLA 352

                         170
                  ....*....|...
gi 2743944752 169 VICGVLILVGGAF 181
Cdd:cd17489   353 AVVVLLALVLYIF 365
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 29-177 3.36e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 38.44  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  29 VLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLASASQGLGMFFAAMCLAGAG 108
Cdd:cd06180    21 LLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAA 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 109 FSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMM-EWTNWRFNWMLLAVICGVLILV 177
Cdd:cd06180   101 SAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLgGGLSWRAGWLALALLSAVLLLL 170
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 15-177 4.13e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 38.33  E-value: 4.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  15 FFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTS-FLPAILLQRIGARLTFCFGFFCVALGFGLASASQ 93
Cdd:cd17330   183 YFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFAS 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  94 GLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFNWMLLAVICGV 173
Cdd:cd17330   263 SVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLI 342


                  ....
gi 2743944752 174 LILV 177
Cdd:cd17330   343 ALFL 346
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 16-177 4.38e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 37.91  E-value: 4.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  16 FVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLASASQGL 95
Cdd:cd17324   208 FLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSP 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  96 GMFFAAMCLAGAGFSLAGNVTAVWlIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFNWMLLAVICGVLI 175
Cdd:cd17324   288 LLLLVGLVLWGLGFFAAHSALQTR-VLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLAL 366


                  ..
gi 2743944752 176 LV 177
Cdd:cd17324   367 LL 368
2_A_01_02 TIGR00880
Multidrug resistance protein;
45-184 5.52e-03

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 36.47  E-value: 5.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  45 GLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLASASQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEW 124
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752 125 FPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFNWMLLAVICGVLILVGGAFITE 184
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 3-177 5.56e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 37.79  E-value: 5.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   3 RKWIIFAVVVAGFFVLNASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFC-FGFFC 81
Cdd:cd06174   200 LKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLlIGLLL 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  82 VALGFGLASASQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWT-NW 160
Cdd:cd06174   280 MALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATfGL 359

                         170
                  ....*....|....*..
gi 2743944752 161 RFNWMLLAVICGVLILV 177
Cdd:cd06174   360 TGAFLVLAVLLLLAAIL 376
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 7-177 6.08e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 37.55  E-value: 6.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752   7 IFAVVVAGFFVLNASTFASLGVVlfVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFC-VALG 85
Cdd:cd17323     1 VFIISFLTFVVTFGSSIYSPALP--QIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIfVIFQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  86 FGLASAsQGLGMFFAAMCLAGAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFNWM 165
Cdd:cd17323    79 IGCALA-PNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFW 157

                         170
                  ....*....|..
gi 2743944752 166 LLAVICGVLILV 177
Cdd:cd17323   158 FLAIISGFCLIL 169
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 19-177 6.21e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 37.56  E-value: 6.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  19 NASTFASLGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLASASQGLGM- 97
Cdd:cd17320   214 FAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGl 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  98 ----FFAAMCLAGAGFSLAGNVTAVWLIgEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRFNWMLLAVICGV 173
Cdd:cd17320   294 slwpLVAPLFLIFFGFGLIFPNATSLAL-EPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLA 372


                  ....
gi 2743944752 174 LILV 177
Cdd:cd17320   373 LLLL 376
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 26-182 7.37e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 37.56  E-value: 7.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2743944752  26 LGVVLFVMADDLGWSYTSAGLSFTILGLAVGLTSFLPAILLQRIGARLTFCFGFFCVALGFGLASASQGLGMFFAAMCLA 105
Cdd:cd17503    15 VNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQ 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2743944752 106 GAGFSLAGNVTAVWLIGEWFPEHTGRMIGLYLMLGGIGDIMGPSLSHYMMEWTNWRfnWM-LLAVICGVLILVGGAFI 182
Cdd:cd17503    95 GFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWR--WIfYINLPIGILALLLAPLL 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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