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Conserved domains on  [gi|2748205151|ref|WP_351259677|]
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MULTISPECIES: HypC/HybG/HupF family hydrogenase formation chaperone [unclassified Streptomyces]

Protein Classification

HypC/HybG/HupF family hydrogenase formation chaperone( domain architecture ID 10001017)

HypC/HybG/HupF family hydrogenase formation chaperone such as Helicobacter hepaticus hydrogenase maturation factor HypC

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HypC COG0298
Hydrogenase maturation factor HybG, HypC/HupF family [Posttranslational modification, protein ...
 1-81 1.19e-31

Hydrogenase maturation factor HybG, HypC/HupF family [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440067  Cd Length: 78  Bit Score: 106.38  E-value: 1.19e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2748205151   1 MCLAVPGRVLEIEERDgtrMATVDFGGVVKEACLEYLPDLQVGEYAIVHVGFALQKLDEDSARQTLELFAQLGMLQEEFG 80
Cdd:COG0298     1 MCLAIPGKVVEILDGD---TALVDVGGVRREVSLALVPEVKVGDYVLVHVGFAIEKIDEEEAEETLELLEELGAALEEVD 77


                  .
gi 2748205151  81 D 81
Cdd:COG0298    78 A 78
 
Name Accession Description Interval E-value
HypC COG0298
Hydrogenase maturation factor HybG, HypC/HupF family [Posttranslational modification, protein ...
 1-81 1.19e-31

Hydrogenase maturation factor HybG, HypC/HupF family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440067  Cd Length: 78  Bit Score: 106.38  E-value: 1.19e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2748205151   1 MCLAVPGRVLEIEERDgtrMATVDFGGVVKEACLEYLPDLQVGEYAIVHVGFALQKLDEDSARQTLELFAQLGMLQEEFG 80
Cdd:COG0298     1 MCLAIPGKVVEILDGD---TALVDVGGVRREVSLALVPEVKVGDYVLVHVGFAIEKIDEEEAEETLELLEELGAALEEVD 77


                  .
gi 2748205151  81 D 81
Cdd:COG0298    78 A 78
HupF_HypC pfam01455
HupF/HypC family;
2-69 5.71e-29

HupF/HypC family;


Pssm-ID: 460218  Cd Length: 64  Bit Score: 98.98  E-value: 5.71e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2748205151   2 CLAVPGRVLEIEERdgtrMATVDFGGVVKEACLEYLPDLQVGEYAIVHVGFALQKLDEDSARQTLELF 69
Cdd:pfam01455   1 CLAIPGKVVEIDDE----MAVVDFGGVRREVSLALVPEVKVGDYVLVHAGFAIEKIDEEEAEETLALL 64
hypC_hupF TIGR00074
hydrogenase assembly chaperone HypC/HupF; This protein is suggested by act as a chaperone for ...
 1-78 4.02e-20

hydrogenase assembly chaperone HypC/HupF; This protein is suggested by act as a chaperone for a hydrogenase large subunit, holding the precursor form before metallocenter nickel incorporation. [SS 12/31/03] More recently proposed additional function is to shuttle the iron atom that has been liganded at the HypC/HypD complex to the precursor of the large hydrogenase (HycE) subunit. . Added metallochaperone and protein mod GO terms. [Protein fate, Protein folding and stabilization, Protein fate, Protein modification and repair]


Pssm-ID: 129184  Cd Length: 76  Bit Score: 77.03  E-value: 4.02e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2748205151   1 MCLAVPGRVLEIEERDgtrmATVDFGGVVKEACLEYLPDLQVGEYAIVHVGFALQKLDEDSARQTLELFAQLGMLQEE 78
Cdd:TIGR00074   1 MCIAIPGQVVEIDENI----ALVEFCGIKRDVSLDLVGEVKVGDYVLVHVGFAISVLDEEEARETLDALQELFDAVEE 74
PRK10413 PRK10413
hydrogenase maturation factor HybG;
1-73 6.20e-13

hydrogenase maturation factor HybG;


Pssm-ID: 182438  Cd Length: 82  Bit Score: 58.99  E-value: 6.20e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2748205151   1 MCLAVPGRVLEIEErDGTRMATVDFGGVVKEACLEYL----PDLQVGEYAIVHVGFALQKLDEDSARQTLELFAQLG 73
Cdd:PRK10413    1 MCIGVPGQVLAVGE-DIHQLAQVEVCGIKRDVNIALIcegnPADLLGQWVLVHVGFAMSIIDEDEAKATLDALRQME 76
 
Name Accession Description Interval E-value
HypC COG0298
Hydrogenase maturation factor HybG, HypC/HupF family [Posttranslational modification, protein ...
 1-81 1.19e-31

Hydrogenase maturation factor HybG, HypC/HupF family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440067  Cd Length: 78  Bit Score: 106.38  E-value: 1.19e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2748205151   1 MCLAVPGRVLEIEERDgtrMATVDFGGVVKEACLEYLPDLQVGEYAIVHVGFALQKLDEDSARQTLELFAQLGMLQEEFG 80
Cdd:COG0298     1 MCLAIPGKVVEILDGD---TALVDVGGVRREVSLALVPEVKVGDYVLVHVGFAIEKIDEEEAEETLELLEELGAALEEVD 77


                  .
gi 2748205151  81 D 81
Cdd:COG0298    78 A 78
HupF_HypC pfam01455
HupF/HypC family;
2-69 5.71e-29

HupF/HypC family;


Pssm-ID: 460218  Cd Length: 64  Bit Score: 98.98  E-value: 5.71e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2748205151   2 CLAVPGRVLEIEERdgtrMATVDFGGVVKEACLEYLPDLQVGEYAIVHVGFALQKLDEDSARQTLELF 69
Cdd:pfam01455   1 CLAIPGKVVEIDDE----MAVVDFGGVRREVSLALVPEVKVGDYVLVHAGFAIEKIDEEEAEETLALL 64
hypC_hupF TIGR00074
hydrogenase assembly chaperone HypC/HupF; This protein is suggested by act as a chaperone for ...
 1-78 4.02e-20

hydrogenase assembly chaperone HypC/HupF; This protein is suggested by act as a chaperone for a hydrogenase large subunit, holding the precursor form before metallocenter nickel incorporation. [SS 12/31/03] More recently proposed additional function is to shuttle the iron atom that has been liganded at the HypC/HypD complex to the precursor of the large hydrogenase (HycE) subunit. . Added metallochaperone and protein mod GO terms. [Protein fate, Protein folding and stabilization, Protein fate, Protein modification and repair]


Pssm-ID: 129184  Cd Length: 76  Bit Score: 77.03  E-value: 4.02e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2748205151   1 MCLAVPGRVLEIEERDgtrmATVDFGGVVKEACLEYLPDLQVGEYAIVHVGFALQKLDEDSARQTLELFAQLGMLQEE 78
Cdd:TIGR00074   1 MCIAIPGQVVEIDENI----ALVEFCGIKRDVSLDLVGEVKVGDYVLVHVGFAISVLDEEEARETLDALQELFDAVEE 74
PRK10413 PRK10413
hydrogenase maturation factor HybG;
1-73 6.20e-13

hydrogenase maturation factor HybG;


Pssm-ID: 182438  Cd Length: 82  Bit Score: 58.99  E-value: 6.20e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2748205151   1 MCLAVPGRVLEIEErDGTRMATVDFGGVVKEACLEYL----PDLQVGEYAIVHVGFALQKLDEDSARQTLELFAQLG 73
Cdd:PRK10413    1 MCIGVPGQVLAVGE-DIHQLAQVEVCGIKRDVNIALIcegnPADLLGQWVLVHVGFAMSIIDEDEAKATLDALRQME 76
PRK10409 PRK10409
HypC/HybG/HupF family hydrogenase formation chaperone;
1-67 1.11e-05

HypC/HybG/HupF family hydrogenase formation chaperone;


Pssm-ID: 182435  Cd Length: 90  Bit Score: 40.55  E-value: 1.11e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2748205151   1 MCLAVPGRVLEIeerdGTRMATVDFGGVVKEACLEYLPDL------QVGEYAIVHVGFALQKLDEDSARQTLE 67
Cdd:PRK10409    1 MCIGVPGQIRTI----DGNQAKVDVCGIQRDVDLTLVGSCdengqpRVGQWVLVHVGFAMSVINEAEARDTLD 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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