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Conserved domains on  [gi|2752240249|ref|WP_353617056|]
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prolyl oligopeptidase family serine peptidase [Coprobacillus sp. K06]

Protein Classification

alpha/beta hydrolase( domain architecture ID 11437497)

alpha/beta hydrolase catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 17-91 1.08e-21

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


:

Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 84.97  E-value: 1.08e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2752240249  17 KQASAVNQVKKSKTPTLFIHGNQDHFVPTYMALELYNACQAEKKLLIVNDAAHGESYHKEKKLVQSSITHFLEKY 91
Cdd:COG1073   178 DEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKELLIVPGAGHVDLYDRPEEEYFDKLAEFFKKN 252
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 17-91 1.08e-21

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 84.97  E-value: 1.08e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2752240249  17 KQASAVNQVKKSKTPTLFIHGNQDHFVPTYMALELYNACQAEKKLLIVNDAAHGESYHKEKKLVQSSITHFLEKY 91
Cdd:COG1073   178 DEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKELLIVPGAGHVDLYDRPEEEYFDKLAEFFKKN 252
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 16-54 4.41e-05

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 39.86  E-value: 4.41e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2752240249  16 FKQASAVNQVKKSKTPTLFIHGNQDHFVPTYMALELYNA 54
Cdd:pfam20434 176 AKSASPITYVDKNDPPFLIIHGDKDPLVPYCQSVLLHEK 214
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 17-91 1.08e-21

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 84.97  E-value: 1.08e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2752240249  17 KQASAVNQVKKSKTPTLFIHGNQDHFVPTYMALELYNACQAEKKLLIVNDAAHGESYHKEKKLVQSSITHFLEKY 91
Cdd:COG1073   178 DEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKELLIVPGAGHVDLYDRPEEEYFDKLAEFFKKN 252
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
15-92 2.45e-13

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 62.73  E-value: 2.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752240249  15 NFKQASAVNQVKKSKTPTLFIHGNQDHFVPTYMALELYNACQA---EKKLLIVNDAAHGESYHKEKKLVQsSITHFLEKY 91
Cdd:COG1506   154 AYAARSPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKagkPVELLVYPGEGHGFSGAGAPDYLE-RILDFLDRH 232


                  .
gi 2752240249  92 V 92
Cdd:COG1506   233 L 233
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
18-92 1.97e-08

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 49.17  E-value: 1.97e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2752240249  18 QASAVNQVKKSKTPTLFIHGNQDHFVPTYMALELYNAC-QAEKKLLIVNDAAHGESYHKEKKLVQSSITHFLEKYV 92
Cdd:COG1647   170 IREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLgSPDKELVWLEDSGHVITLDKDREEVAEEILDFLERLA 245
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
16-90 5.04e-07

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 45.38  E-value: 5.04e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2752240249  16 FKQASAVNQVKKSKTPTLFIHGNQDHFVPTYMALELYNACQAEKKLLIVNDAAHGESYHKEKKLVQSSITHFLEK 90
Cdd:COG2267   147 LRALRLAEALARIDVPVLVLHGGADRVVPPEAARRLAARLSPDVELVLLPGARHELLNEPAREEVLAAILAWLER 221
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 16-54 4.41e-05

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 39.86  E-value: 4.41e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2752240249  16 FKQASAVNQVKKSKTPTLFIHGNQDHFVPTYMALELYNA 54
Cdd:pfam20434 176 AKSASPITYVDKNDPPFLIIHGDKDPLVPYCQSVLLHEK 214
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
19-76 6.27e-05

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 39.56  E-value: 6.27e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2752240249  19 ASAVNQVKKSKTPTLFIHGNQDHFVPTYMALELYNACQA---EKKLLIVNDAAHG------ESYHKE 76
Cdd:COG0412   146 DDLLDLAARIKAPVLLLYGEKDPLVPPEQVAALEAALAAagvDVELHVYPGAGHGftnpgrPRYDPA 212
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
15-91 7.61e-05

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 39.14  E-value: 7.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2752240249  15 NFKQASAVN--QVKKSKTPTLFIHGNQDHFVPTYMALELYNACQAEKK---LLIVNDAAHGESYHKEKKLVQSSITHFLE 89
Cdd:pfam00326 128 GYDYLSPYSpaDNVKVYPPLLLIHGLLDDRVPPWQSLKLVAALQRKGVpflLLIFPDEGHGIGKPRNKVEEYARELAFLL 207


                  ..
gi 2752240249  90 KY 91
Cdd:pfam00326 208 EY 209
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
31-69 1.08e-03

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 35.91  E-value: 1.08e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2752240249  31 PTLFIHGNQDHFVPTYMALELYNACQAEKKLLIVNDAAH 69
Cdd:COG2945   144 PTLVIHGEQDEVVPPAEVLDWARPLSPPLPVVVVPGADH 182
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 16-69 2.56e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 34.98  E-value: 2.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2752240249  16 FKQASAVNQVKKSKTPTLFIHGNQDHFVPTYMALELYNAC-QAEkkLLIVNDAAH 69
Cdd:COG0596   148 LARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLpNAE--LVVLPGAGH 200
FSH1 pfam03959
Serine hydrolase (FSH1); This is a family of serine hydrolases.
 29-63 2.87e-03

Serine hydrolase (FSH1); This is a family of serine hydrolases.


Pssm-ID: 461110  Cd Length: 208  Bit Score: 34.95  E-value: 2.87e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2752240249  29 KTPTLFIHGNQDHFVPTYMALELYNACQAEKKLLI 63
Cdd:pfam03959 158 QTPSLHVIGELDTVVPEERSEKLAEACKNSPTVLE 192
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 31-69 8.80e-03

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 33.63  E-value: 8.80e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2752240249  31 PTLFIHGNQDHFVPTYMALELYNACqAEKKLLIVNDAAH 69
Cdd:pfam00561 201 PTLIIWGDQDPLVPPQALEKLAQLF-PNARLVVIPDAGH 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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