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Conserved domains on  [gi|2753763436|ref|WP_353891652|]
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MurR/RpiR family transcriptional regulator [Lactococcus lactis]

Protein Classification

MurR/RpiR family transcriptional regulator( domain architecture ID 11448252)

MurR/RpiR family transcriptional regulator similar to Escherichia coli MurR, which represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid

CATH:  1.10.10.10
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  15808743|8576032
SCOP:  4000148

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-273 2.47e-67

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


:

Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 210.55  E-value: 2.47e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436   1 MNILDQIQVNFQNFFESEKKIAEFILKNPKKVIDMPIALLARNSNVSEASISRFCKKLNLTGFHQLKIELA-----RIQD 75
Cdd:COG1737     5 MSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAqelaeGLSS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436  76 NENIE-VNKNTSLNELIKNISKIKTTELIAATDNLDIDNLQSIIKLITNVKLTHFVASGNTIPVAQDASYRFNQLGITSV 154
Cdd:COG1737    85 YERLRrLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436 155 VFD-DWQVQTAFTLNMRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNFHLTSFSRDYFFHNDY 233
Cdd:COG1737   165 LLDgDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSSA 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2753763436 234 YFSRLSAMYLIELIF--LILSQDKSRLENIKLHEQIISEAKL 273
Cdd:COG1737   245 FSSRVAQLALIDALAaaVAQRDGDKARERLERTEALLSELRE 286
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-273 2.47e-67

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 210.55  E-value: 2.47e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436   1 MNILDQIQVNFQNFFESEKKIAEFILKNPKKVIDMPIALLARNSNVSEASISRFCKKLNLTGFHQLKIELA-----RIQD 75
Cdd:COG1737     5 MSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAqelaeGLSS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436  76 NENIE-VNKNTSLNELIKNISKIKTTELIAATDNLDIDNLQSIIKLITNVKLTHFVASGNTIPVAQDASYRFNQLGITSV 154
Cdd:COG1737    85 YERLRrLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436 155 VFD-DWQVQTAFTLNMRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNFHLTSFSRDYFFHNDY 233
Cdd:COG1737   165 LLDgDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSSA 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2753763436 234 YFSRLSAMYLIELIF--LILSQDKSRLENIKLHEQIISEAKL 273
Cdd:COG1737   245 FSSRVAQLALIDALAaaVAQRDGDKARERLERTEALLSELRE 286
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 1-221 4.94e-40

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 140.13  E-value: 4.94e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436   1 MNILDQIQVNFQNFFESEKKIAEFILKNPKKVIDMPIALLARNSNVSEASISRFCKKLNLTGFHQLKIELARIQDNENIE 80
Cdd:PRK11302    1 MNMLEKIQSRLEHLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFKLHLAQSLANGTPY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436  81 VNKNT----SLNELIKNISKIKTTELIAATDNLDIDNLQSIIKLITNVKLTHFVASGNTIPVAQDASYRFNQLGITSVVF 156
Cdd:PRK11302   81 VNRNVeeddSVEAYTGKIFESAMASLDHARQSLDPSAINRAVDLLTQAKKISFFGLGASAAVAHDAQNKFFRFNVPVVYF 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2753763436 157 DDWQVQTAFTLNMRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNhPDSPIARLSNFHLT 221
Cdd:PRK11302  161 DDIVMQRMSCMNSSDGDVVVLISHTGRTKSLVELAQLARENGATVIAITS-AGSPLAREATLALT 224
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 112-249 3.49e-36

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 125.80  E-value: 3.49e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436 112 DNLQSIIKLITNVKLTHFVASGNTIPVAQDASYRFNQLGITSVVFDDWQVQTAFTLNMRKEDLLIVISNSGESKSLIKLI 191
Cdd:cd05013     1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2753763436 192 NIAKEKKISTISITNHPDSPIARLSNFHLTSFSRDYFFHNDYYFSRLSAMYLIELIFL 249
Cdd:cd05013    81 EIAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALFL 138
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
 1-71 3.23e-17

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 74.29  E-value: 3.23e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2753763436   1 MNILDQIQVNFQNFFESEKKIAEFILKNPKKVIDMPIALLARNSNVSEASISRFCKKLNLTGFHQLKIELA 71
Cdd:pfam01418   1 MGLLEKIQSRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALA 71
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-273 2.47e-67

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 210.55  E-value: 2.47e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436   1 MNILDQIQVNFQNFFESEKKIAEFILKNPKKVIDMPIALLARNSNVSEASISRFCKKLNLTGFHQLKIELA-----RIQD 75
Cdd:COG1737     5 MSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAqelaeGLSS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436  76 NENIE-VNKNTSLNELIKNISKIKTTELIAATDNLDIDNLQSIIKLITNVKLTHFVASGNTIPVAQDASYRFNQLGITSV 154
Cdd:COG1737    85 YERLRrLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436 155 VFD-DWQVQTAFTLNMRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNFHLTSFSRDYFFHNDY 233
Cdd:COG1737   165 LLDgDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSSA 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2753763436 234 YFSRLSAMYLIELIF--LILSQDKSRLENIKLHEQIISEAKL 273
Cdd:COG1737   245 FSSRVAQLALIDALAaaVAQRDGDKARERLERTEALLSELRE 286
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 1-221 4.94e-40

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 140.13  E-value: 4.94e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436   1 MNILDQIQVNFQNFFESEKKIAEFILKNPKKVIDMPIALLARNSNVSEASISRFCKKLNLTGFHQLKIELARIQDNENIE 80
Cdd:PRK11302    1 MNMLEKIQSRLEHLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFKLHLAQSLANGTPY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436  81 VNKNT----SLNELIKNISKIKTTELIAATDNLDIDNLQSIIKLITNVKLTHFVASGNTIPVAQDASYRFNQLGITSVVF 156
Cdd:PRK11302   81 VNRNVeeddSVEAYTGKIFESAMASLDHARQSLDPSAINRAVDLLTQAKKISFFGLGASAAVAHDAQNKFFRFNVPVVYF 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2753763436 157 DDWQVQTAFTLNMRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNhPDSPIARLSNFHLT 221
Cdd:PRK11302  161 DDIVMQRMSCMNSSDGDVVVLISHTGRTKSLVELAQLARENGATVIAITS-AGSPLAREATLALT 224
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 112-249 3.49e-36

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 125.80  E-value: 3.49e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436 112 DNLQSIIKLITNVKLTHFVASGNTIPVAQDASYRFNQLGITSVVFDDWQVQTAFTLNMRKEDLLIVISNSGESKSLIKLI 191
Cdd:cd05013     1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2753763436 192 NIAKEKKISTISITNHPDSPIARLSNFHLTSFSRDYFFHNDYYFSRLSAMYLIELIFL 249
Cdd:cd05013    81 EIAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALFL 138
PRK15482 PRK15482
HTH-type transcriptional regulator MurR;
14-269 5.88e-25

HTH-type transcriptional regulator MurR;


Pssm-ID: 185379 [Multi-domain]  Cd Length: 285  Bit Score: 100.54  E-value: 5.88e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436  14 FFESEKKIAEFILKNPKKVIDMPIALLARNSNVSEASISRFCKKLNLTGFHQLKIELarIQDNENIEVNKNTSLNELIKN 93
Cdd:PRK15482   14 FTENEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMAL--IGEYSASREKTNATALHLHSS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436  94 ISKIKTTELIAATDN-------------LDIDNLQSIIKLITNVKLTHFVASGNTIPVAQDASYRFNQLGITSVVFDDWQ 160
Cdd:PRK15482   92 ITSDDSLEVIARKLNrekelaleqtcalFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVACEADTH 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436 161 VQTAFTLNMRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNFHLTSFSRDYFFHNDYYFSRLSA 240
Cdd:PRK15482  172 VQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLDTVSGETEWRSSSMSTRTAQ 251

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2753763436 241 MYLIELIFLILSQ--DKSRLENIKLHEQIIS 269
Cdd:PRK15482  252 NSVTDLLFVGLVQlnDVESLKMIQRSSELTQ 282
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
3-220 4.81e-24

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 101.15  E-value: 4.81e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436   3 ILDQIQVNFQNFFESEKKIAEFILKNPKKVIDMPIALLARNSNVSEASISRFCKKLNLTGFHQLKIELAR----IQDNEN 78
Cdd:PRK14101  343 VFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATgltgTIPMSH 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436  79 IEVNKNTSLNELIKNISKIKTTELIAATDNLDIDNLQSIIKLITNVKLTHFVASGNTIPVAQDASYRFNQLGITSVVFDD 158
Cdd:PRK14101  423 SQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSNIVAQDAHYKFFRFGIPTIAYGD 502

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2753763436 159 WQVQTAFTLNMRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHpDSPIARLSNFHL 220
Cdd:PRK14101  503 LYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSS-NTPLAKRATVAL 563
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
6-266 3.21e-21

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 90.59  E-value: 3.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436   6 QIQVNFQNFFESEKKIAEFILKNPKKVIDMPIALLARNSNVSEASISRFCKKLNLTGFHQLKIELA--RIQDNENI--EV 81
Cdd:PRK11337   18 YIRMKQEGLTPLESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRSALEdyFSQSEQVLhsEL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436  82 NKNTSLNELIKNISKIKTTELIAATDNLDIDNLQSIIKLITNVKLTHFVASGNTIPVAQDASYRFNQLGITSVVFDDWQV 161
Cdd:PRK11337   98 SFDDAPQDVVNKVFNTSLQAIEETQSILDVDEFHRAARFFYQARQRDLYGAGGSAAIARDVQHKFLRIGVRCQAYDDAHI 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436 162 QTAFTLNMRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNFHLTSFSRDYFFHNDYYFSRLSAM 241
Cdd:PRK11337  178 MLMSAALLQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSPIAKLADYVICSTAQGSPLLGENAAARIAQL 257

                         250       260
                  ....*....|....*....|....*
gi 2753763436 242 YLIELIFLILSQdksrlENIKLHEQ 266
Cdd:PRK11337  258 NILDAFFVSVAQ-----LNIEQAEI 277
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
 1-71 3.23e-17

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 74.29  E-value: 3.23e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2753763436   1 MNILDQIQVNFQNFFESEKKIAEFILKNPKKVIDMPIALLARNSNVSEASISRFCKKLNLTGFHQLKIELA 71
Cdd:pfam01418   1 MGLLEKIQSRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALA 71
PRK11557 PRK11557
MurR/RpiR family transcriptional regulator;
6-196 9.52e-15

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183195 [Multi-domain]  Cd Length: 278  Bit Score: 72.11  E-value: 9.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436   6 QIQVNFQNFFESEKKIAEFILKNPKKVIDMPIALLARNSNVSEASISRFCKKLNLTGFHQLKIE----LARIQDNENIEV 81
Cdd:PRK11557    2 RIRQRYPGLAQSDRKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLAlseaLASQPEPPSVPV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436  82 NKNTSLNELIKNISKIKTTELIAATD-NLDIDN---LQSIIKLITN---VKLTHFVASGntiPVAQDASYRFNQLGITSV 154
Cdd:PRK11557   82 HNQIRGDDPLRLVGEKLIKENTAAMRaTLDVNSeekLHECVTMLRSarrIILTGIGASG---LVAQNFAWKLMKIGINAV 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2753763436 155 VFDDWQVQTAFTLNMRKEDLLIVISNSGESKSliklINIAKE 196
Cdd:PRK11557  159 AERDMHALLATVQALSPDDLLLAISYSGERRE----LNLAAD 196
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 129-221 2.64e-14

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 68.09  E-value: 2.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436 129 FVASGNTIPVAQDASYRFNQLG-ITSVVFDDWQVQTAFTLNMRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNH 207
Cdd:pfam01380  10 VIGRGTSYAIALELALKFEEIGyKVVEVELASELRHGVLALVDEDDLVIAISYSGETKDLLAAAELAKARGAKIIAITDS 89

                          90
                  ....*....|....
gi 2753763436 208 PDSPIARLSNFHLT 221
Cdd:pfam01380  90 PGSPLAREADHVLY 103
SIS_GlmS_GlmD_1 cd05008
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ...
 129-220 4.53e-14

SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.


Pssm-ID: 240141 [Multi-domain]  Cd Length: 126  Bit Score: 67.14  E-value: 4.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436 129 FVASGNTIPVAQDASYRFNQLGITSVvfddwQVQTAFTLNMR-----KEDLLIVISNSGESKSLIKLINIAKEKKISTIS 203
Cdd:cd05008     4 IVGCGTSYHAALVAKYLLERLAGIPV-----EVEAASEFRYRrplldEDTLVIAISQSGETADTLAALRLAKEKGAKTVA 78

                          90
                  ....*....|....*..
gi 2753763436 204 ITNHPDSPIARLSNFHL 220
Cdd:cd05008    79 ITNVVGSTLAREADYVL 95
GutQ COG0794
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ...
 169-220 3.49e-12

D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440557 [Multi-domain]  Cd Length: 317  Bit Score: 65.38  E-value: 3.49e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2753763436 169 MRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNFHL 220
Cdd:COG0794    89 ITPGDVVIAISNSGETEELLALLPLLKRLGVPLIAITGNPDSTLARAADVVL 140
SIS_Kpsf cd05014
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ...
 169-221 2.55e-11

KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.


Pssm-ID: 240145 [Multi-domain]  Cd Length: 128  Bit Score: 59.86  E-value: 2.55e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2753763436 169 MRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNFHLT 221
Cdd:cd05014    45 VTPGDVVIAISNSGETDELLNLLPHLKRRGAPIIAITGNPNSTLAKLSDVVLD 97
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 88-220 7.43e-10

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 56.81  E-value: 7.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436  88 NELIKNISKikttELIAATDNLDIDNLQSIIKLITNVKLThFVA----SGntiPVAQDASYRFNQLGITS-VVFDDwqvq 162
Cdd:cd05005     1 MEYLSLILE----EIENVADKIDEEELDKLISAILNAKRI-FVYgagrSG---LVAKAFAMRLMHLGLNVyVVGET---- 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2753763436 163 taFTLNMRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNFHL 220
Cdd:cd05005    69 --TTPAIGPGDLLIAISGSGETSSVVNAAEKAKKAGAKVVLITSNPDSPLAKLADVVV 124
AgaS COG2222
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ...
 101-221 3.55e-09

Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441824 [Multi-domain]  Cd Length: 336  Bit Score: 56.45  E-value: 3.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436 101 ELIAATDNLDIDNLQSIIKLITNVKLTH--FVASGNTIPVAQDASYRFN-QLGITSVVFD--DWQVQTAFtLNMRKeDLL 175
Cdd:COG2222     9 EAWRRALAALAAAIAALLARLRAKPPRRvvLVGAGSSDHAAQAAAYLLErLLGIPVAALApsELVVYPAY-LKLEG-TLV 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2753763436 176 IVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNFHLT 221
Cdd:COG2222    87 VAISRSGNSPEVVAALELAKARGARTLAITNNPDSPLAEAADRVLP 132
PRK10892 PRK10892
arabinose-5-phosphate isomerase KdsD;
172-220 1.61e-07

arabinose-5-phosphate isomerase KdsD;


Pssm-ID: 182814 [Multi-domain]  Cd Length: 326  Bit Score: 51.65  E-value: 1.61e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2753763436 172 EDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNFHL 220
Cdd:PRK10892   95 QDVVIAISNSGESSEILALIPVLKRLHVPLICITGRPESSMARAADIHL 143
SIS_GmhA cd05006
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose ...
 170-220 8.00e-07

Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).


Pssm-ID: 240139 [Multi-domain]  Cd Length: 177  Bit Score: 48.27  E-value: 8.00e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2753763436 170 RKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNFHL 220
Cdd:cd05006   100 QPGDVLIGISTSGNSPNVLKALEAAKERGMKTIALTGRDGGKLLELADIEI 150
PTZ00295 PTZ00295
glucosamine-fructose-6-phosphate aminotransferase; Provisional
 102-217 4.12e-06

glucosamine-fructose-6-phosphate aminotransferase; Provisional


Pssm-ID: 240349 [Multi-domain]  Cd Length: 640  Bit Score: 47.71  E-value: 4.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436 102 LIAATDNLDIDNLQSIIKLITNVKLTHFVASGNTIPVAQDASYRFNQLGitsvVFDDWQVQTAFTLNM----RKEDLLIV 177
Cdd:PTZ00295  300 LSGYNNRVKLGGLDQYLEELLNIKNLILVGCGTSYYAALFAASIMQKLK----CFNTVQVIDASELTLyrlpDEDAGVIF 375

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2753763436 178 ISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSN 217
Cdd:PTZ00295  376 ISQSGETLDVVRALNLADELNLPKISVVNTVGSLIARSTD 415
SIS_1 cd05710
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ...
 171-243 1.62e-05

A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240214 [Multi-domain]  Cd Length: 120  Bit Score: 43.33  E-value: 1.62e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2753763436 171 KEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNFHLTSFSRDYFFHNDYYFSRLSAMYL 243
Cdd:cd05710    47 EKSVVILASHSGNTKETVAAAKFAKEKGATVIGLTDDEDSPLAKLADYVIVYGFEIDAVEEKYLLLYMLALRL 119
PRK00331 PRK00331
isomerizing glutamine--fructose-6-phosphate transaminase;
169-220 1.75e-05

isomerizing glutamine--fructose-6-phosphate transaminase;


Pssm-ID: 234729 [Multi-domain]  Cd Length: 604  Bit Score: 45.80  E-value: 1.75e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2753763436 169 MRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNFHL 220
Cdd:PRK00331  334 LSPKTLVIAISQSGETADTLAALRLAKELGAKTLAICNVPGSTIARESDAVL 385
SIS cd04795
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 129-205 3.41e-05

SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240112 [Multi-domain]  Cd Length: 87  Bit Score: 41.59  E-value: 3.41e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2753763436 129 FVASGNTIPVAQDASYRFNQL-GITSVVFDDWQVQTAFTL-NMRKEDLLIVISNSGESKSLIKLINIAKEKKISTISIT 205
Cdd:cd04795     3 VIGIGGSGAIAAYFALELLELtGIEVVALIATELEHASLLsLLRKGDVVIALSYSGRTEELLAALEIAKELGIPVIAIT 81
GlmS COG0449
Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase ...
 169-220 1.33e-04

Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440218 [Multi-domain]  Cd Length: 610  Bit Score: 43.08  E-value: 1.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2753763436 169 MRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNFHL 220
Cdd:COG0449   339 VDPGTLVIAISQSGETADTLAALREAKEKGAKVLAICNVVGSTIARESDAVL 390
SIS_2 pfam13580
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 170-205 3.63e-04

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 433326 [Multi-domain]  Cd Length: 138  Bit Score: 39.89  E-value: 3.63e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2753763436 170 RKEDLLIVISNSGESKSLIKLINIAKEKKISTISIT 205
Cdd:pfam13580 102 RPGDVLIVISNSGINAVPVEAALEAKERGMKVIALT 137
gutQ PRK11543
arabinose-5-phosphate isomerase GutQ;
172-213 4.84e-03

arabinose-5-phosphate isomerase GutQ;


Pssm-ID: 183186 [Multi-domain]  Cd Length: 321  Bit Score: 37.82  E-value: 4.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2753763436 172 EDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIA 213
Cdd:PRK11543   90 RDVMLFISYSGGAKELDLIIPRLEDKSIALLAMTGKPTSPLG 131
PTZ00394 PTZ00394
glucosamine-fructose-6-phosphate aminotransferase; Provisional
 169-269 5.12e-03

glucosamine-fructose-6-phosphate aminotransferase; Provisional


Pssm-ID: 173585 [Multi-domain]  Cd Length: 670  Bit Score: 37.93  E-value: 5.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753763436 169 MRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNF--HLTSFSRDYFFHNDYYFSRLSAMYLIEl 246
Cdd:PTZ00394  399 IQRDDVCFFVSQSGETADTLMALQLCKEAGAMCVGITNVVGSSISRLTHYaiHLNAGVEVGVASTKAYTSQVVVLTLVA- 477

                          90       100
                  ....*....|....*....|...
gi 2753763436 247 ifLILSQDKSRLEniKLHEQIIS 269
Cdd:PTZ00394  478 --LLLSSDSVRLQ--ERRNEIIR 496
SIS_Etherase cd05007
N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ...
 167-218 6.72e-03

N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid carries a unique D-lactyl ether substituent at the C3 position. The etherase catalyzes the cleavage of the lactyl ether bond of N-acetylmuramic acid 6-phosphate.


Pssm-ID: 240140 [Multi-domain]  Cd Length: 257  Bit Score: 37.12  E-value: 6.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2753763436 167 LNMRKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNF 218
Cdd:cd05007   114 INLTERDVVIGIAASGRTPYVLGALRYARARGALTIGIACNPGSPLLQLADI 165
PRK13938 PRK13938
phosphoheptose isomerase; Provisional
 153-226 7.01e-03

phosphoheptose isomerase; Provisional


Pssm-ID: 139997 [Multi-domain]  Cd Length: 196  Bit Score: 36.64  E-value: 7.01e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2753763436 153 SVVFDDWQVQTAFTLNM----RKEDLLIVISNSGESKSLIKLINIAKEKKISTISITNHPDSPIARLSNFHLTSFSRD 226
Cdd:PRK13938   91 TAVANDYDYDTVFARALegsaRPGDTLFAISTSGNSMSVLRAAKTARELGVTVVAMTGESGGQLAEFADFLINVPSRD 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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