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Conserved domains on  [gi|2755059532|ref|WP_354123143|]
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thiolase family protein [Burkholderia ambifaria]

Protein Classification

thiolase family protein( domain architecture ID 10093593)

thiolase family protein similar to Sulfurisphaera tokodaii acetyl-CoA C-acetyltransferase, which catalyzes the transfer of an acetyl group from acetyl-CoA to another molecule of acetyl-CoA to form acetoacetyl-CoA

CATH:  3.40.47.10
EC:  2.3.1.-
Gene Ontology:  GO:0016746
PubMed:  16356722

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCP-x_thiolase cd00829
Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; ...
 9-391 1.23e-118

Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.


:

Pssm-ID: 238425 [Multi-domain]  Cd Length: 375  Bit Score: 349.64  E-value: 1.23e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   9 AGVGMTEFGVRPDVSVKELTRAAVVDALADAGADPTAIEAAYFGNTCQDVLEGQVvvaGQMALRSMGFERIPIVNVENAC 88
Cdd:cd00829     1 VGVGMTPFGRRSDRSPLELAAEAARAALDDAGLEPADIDAVVVGNAAGGRFQSFP---GALIAEYLGLLGKPATRVEAAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  89 ATGATALHQAIMHVRSGAADIVLAVGAEKLSigDKTKALGVFDGGVDVNDRQGvravlEELGGALpedgkphslFMDVYA 168
Cdd:cd00829    78 ASGSAAVRAAAAAIASGLADVVLVVGAEKMS--DVPTGDEAGGRASDLEWEGP-----EPPGGLT---------PPALYA 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 169 ALARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFRAEMSVEEILAARPVSGPLTVPMCAPLTDGASAVVVCNAAGLKR 248
Cdd:cd00829   142 LAARRYMHRYGTTREDLAKVAVKNHRNAARNPYAQFRKPITVEDVLNSRMIADPLRLLDCCPVSDGAAAVVLASEERARE 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 249 LdGSRPIRILAAVLQSGTVRPLSAWDCSV---TRLAAQAAYEQAGVGPQDISVAEVHDASSFGELLQSELLGFCEIGSGG 325
Cdd:cd00829   222 L-TDRPVWILGVGAASDTPSLSERDDFLSldaARLAARRAYKMAGITPDDIDVAELYDCFTIAELLALEDLGFCEKGEGG 300

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2755059532 326 RFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCGARQVAGARIALAENGGG 391
Cdd:cd00829   301 KLVREGDTAIGGDLPVNTSGGLLSKGHPLGATGLAQAVEAVRQLRGEAGARQVPGARVGLAHNIGG 366
 
Name Accession Description Interval E-value
SCP-x_thiolase cd00829
Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; ...
 9-391 1.23e-118

Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.


Pssm-ID: 238425 [Multi-domain]  Cd Length: 375  Bit Score: 349.64  E-value: 1.23e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   9 AGVGMTEFGVRPDVSVKELTRAAVVDALADAGADPTAIEAAYFGNTCQDVLEGQVvvaGQMALRSMGFERIPIVNVENAC 88
Cdd:cd00829     1 VGVGMTPFGRRSDRSPLELAAEAARAALDDAGLEPADIDAVVVGNAAGGRFQSFP---GALIAEYLGLLGKPATRVEAAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  89 ATGATALHQAIMHVRSGAADIVLAVGAEKLSigDKTKALGVFDGGVDVNDRQGvravlEELGGALpedgkphslFMDVYA 168
Cdd:cd00829    78 ASGSAAVRAAAAAIASGLADVVLVVGAEKMS--DVPTGDEAGGRASDLEWEGP-----EPPGGLT---------PPALYA 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 169 ALARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFRAEMSVEEILAARPVSGPLTVPMCAPLTDGASAVVVCNAAGLKR 248
Cdd:cd00829   142 LAARRYMHRYGTTREDLAKVAVKNHRNAARNPYAQFRKPITVEDVLNSRMIADPLRLLDCCPVSDGAAAVVLASEERARE 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 249 LdGSRPIRILAAVLQSGTVRPLSAWDCSV---TRLAAQAAYEQAGVGPQDISVAEVHDASSFGELLQSELLGFCEIGSGG 325
Cdd:cd00829   222 L-TDRPVWILGVGAASDTPSLSERDDFLSldaARLAARRAYKMAGITPDDIDVAELYDCFTIAELLALEDLGFCEKGEGG 300

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2755059532 326 RFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCGARQVAGARIALAENGGG 391
Cdd:cd00829   301 KLVREGDTAIGGDLPVNTSGGLLSKGHPLGATGLAQAVEAVRQLRGEAGARQVPGARVGLAHNIGG 366
PRK08256 PRK08256
lipid-transfer protein; Provisional
 4-390 7.05e-108

lipid-transfer protein; Provisional


Pssm-ID: 181327 [Multi-domain]  Cd Length: 391  Bit Score: 323.00  E-value: 7.05e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   4 MPVWIAGVGMTEFgVRP------DVSVKELTRAAVVDAladaGADPTAIEAAYFGNTCQDVlegqvvVAGQMALRSMGFE 77
Cdd:PRK08256    1 NKVFVAGVGMTPF-EKPgaswdyPDMAAEAGRAALADA----GIDYDAVQQAYVGYVYGDS------TSGQRALYEVGMT 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  78 RIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLSIGdktkALG-VFDGGVDVNDRQgvRAVLEELGGAlpeD 156
Cdd:PRK08256   70 GIPIVNVNNNCSTGSTALFLARQAVRSGAADCALALGFEQMQPG----ALGsVWDDRPSPLERF--DKALAELQGF---D 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 157 GKPHSLFMdvYAALARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFRAEMSVEEILAARPVSGPLTVPMCAPLTDGAS 236
Cdd:PRK08256  141 PAPPALRM--FGGAGREHMEKYGTTAETFAKIGVKARRHAANNPYAQFRDEYTLEDVLASPMIWGPLTRLQCCPPTCGAA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 237 AVVVCNAAGLKRLDGSRPIRILAAVLQSGTVRPLSAWDC------SVTRLAAQAAYEQAGVGPQDISVAEVHDASSFGEL 310
Cdd:PRK08256  219 AAIVCSEEFARKHGLDRAVEIVAQAMTTDTPSTFDGRSMidlvgyDMTRAAAQQVYEQAGIGPEDIDVVELHDCFSANEL 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 311 LQSELLGFCEIGSGGRFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCGARQVAGARIALAENGG 390
Cdd:PRK08256  299 LTYEALGLCPEGEAEKFIDDGDNTYGGRWVVNPSGGLLSKGHPLGATGLAQCAELTWQLRGTAGARQVEGARLALQHNLG 378
Thiolase_N pfam00108
Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl ...
 6-244 9.12e-16

Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.


Pssm-ID: 459676 [Multi-domain]  Cd Length: 260  Bit Score: 76.57  E-value: 9.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   6 VWIAGVGMTEFG----VRPDVSVKELTRAAVVDALADAGADPTAIEAAYFGNTCQDVlEGQVVvAGQMALRSMGFERIPI 81
Cdd:pfam00108   1 VVIVSAARTPFGsfggSLKDVSAVELGAEAIKAALERAGVDPEDVDEVIVGNVLQAG-EGQNP-ARQAALKAGIPDSAPA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  82 VNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLSIGDKtkalgvfdgGVDVNDRQGVRAVLEELGGALPEDGkPHS 161
Cdd:pfam00108  79 VTINKVCGSGLKAVYLAAQSIASGDADVVLAGGVESMSHAPY---------ALPTDARSGLKHGDEKKHDLLIPDG-LTD 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 162 LFMDVYAAL-ARAHMNAFGTTREQLALIASKNHEHAVHNPLA-HFRAEM-----------------------SVEEILAA 216
Cdd:pfam00108 149 AFNGYHMGLtAENVAKKYGISREEQDAFAVKSHQKAAAAPKAgKFKDEIvpvtvkgrkgkptvdkdegirppTTAEPLAK 228

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2755059532 217 -RPV---SGPLTVPMCAPLTDGASAVVVCNAA 244
Cdd:pfam00108 229 lKPAfdkEGTVTAGNASPINDGAAAVLLMSES 260
PaaJ COG0183
Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is ...
 40-304 4.61e-09

Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 439953 [Multi-domain]  Cd Length: 391  Bit Score: 57.77  E-value: 4.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  40 GADPTAIEAAYFGNTCQdVLEGQVVvAGQMALRSmGF-ERIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKL 118
Cdd:COG0183    42 GLDPEAVDDVILGCVLQ-AGQGQNP-ARQAALLA-GLpESVPAVTVNRVCGSGLQAVALAAQAIAAGDADVVIAGGVESM 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 119 SigdkTKALGVFDGgvdvndRQGVRAvleelgGALPEDGKPHSLFMDVYAALaraHM--------NAFGTTREQLALIAS 190
Cdd:COG0183   119 S----RAPMLLPKA------RWGYRM------NAKLVDPMINPGLTDPYTGL---SMgetaenvaERYGISREEQDAFAL 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 191 KNHEHA---------------VHNPLA----------HFRAEMSVEEILAARPV---SGPLTVPMCAPLTDGASAVVVCN 242
Cdd:COG0183   180 RSHQRAaaaiaagrfddeivpVEVPDRkgevvvdrdeGPRPDTTLEKLAKLKPAfkkDGTVTAGNASGINDGAAALLLMS 259

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2755059532 243 AAGLKRLDgsrpIRILAAVLQSGTVRplsawdCSVTRL------AAQAAYEQAGVGPQDISVAEVHDA 304
Cdd:COG0183   260 EEAAKELG----LKPLARIVAYAVAG------VDPEIMgigpvpATRKALARAGLTLDDIDLIEINEA 317
 
Name Accession Description Interval E-value
SCP-x_thiolase cd00829
Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; ...
 9-391 1.23e-118

Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.


Pssm-ID: 238425 [Multi-domain]  Cd Length: 375  Bit Score: 349.64  E-value: 1.23e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   9 AGVGMTEFGVRPDVSVKELTRAAVVDALADAGADPTAIEAAYFGNTCQDVLEGQVvvaGQMALRSMGFERIPIVNVENAC 88
Cdd:cd00829     1 VGVGMTPFGRRSDRSPLELAAEAARAALDDAGLEPADIDAVVVGNAAGGRFQSFP---GALIAEYLGLLGKPATRVEAAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  89 ATGATALHQAIMHVRSGAADIVLAVGAEKLSigDKTKALGVFDGGVDVNDRQGvravlEELGGALpedgkphslFMDVYA 168
Cdd:cd00829    78 ASGSAAVRAAAAAIASGLADVVLVVGAEKMS--DVPTGDEAGGRASDLEWEGP-----EPPGGLT---------PPALYA 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 169 ALARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFRAEMSVEEILAARPVSGPLTVPMCAPLTDGASAVVVCNAAGLKR 248
Cdd:cd00829   142 LAARRYMHRYGTTREDLAKVAVKNHRNAARNPYAQFRKPITVEDVLNSRMIADPLRLLDCCPVSDGAAAVVLASEERARE 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 249 LdGSRPIRILAAVLQSGTVRPLSAWDCSV---TRLAAQAAYEQAGVGPQDISVAEVHDASSFGELLQSELLGFCEIGSGG 325
Cdd:cd00829   222 L-TDRPVWILGVGAASDTPSLSERDDFLSldaARLAARRAYKMAGITPDDIDVAELYDCFTIAELLALEDLGFCEKGEGG 300

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2755059532 326 RFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCGARQVAGARIALAENGGG 391
Cdd:cd00829   301 KLVREGDTAIGGDLPVNTSGGLLSKGHPLGATGLAQAVEAVRQLRGEAGARQVPGARVGLAHNIGG 366
PRK08256 PRK08256
lipid-transfer protein; Provisional
 4-390 7.05e-108

lipid-transfer protein; Provisional


Pssm-ID: 181327 [Multi-domain]  Cd Length: 391  Bit Score: 323.00  E-value: 7.05e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   4 MPVWIAGVGMTEFgVRP------DVSVKELTRAAVVDAladaGADPTAIEAAYFGNTCQDVlegqvvVAGQMALRSMGFE 77
Cdd:PRK08256    1 NKVFVAGVGMTPF-EKPgaswdyPDMAAEAGRAALADA----GIDYDAVQQAYVGYVYGDS------TSGQRALYEVGMT 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  78 RIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLSIGdktkALG-VFDGGVDVNDRQgvRAVLEELGGAlpeD 156
Cdd:PRK08256   70 GIPIVNVNNNCSTGSTALFLARQAVRSGAADCALALGFEQMQPG----ALGsVWDDRPSPLERF--DKALAELQGF---D 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 157 GKPHSLFMdvYAALARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFRAEMSVEEILAARPVSGPLTVPMCAPLTDGAS 236
Cdd:PRK08256  141 PAPPALRM--FGGAGREHMEKYGTTAETFAKIGVKARRHAANNPYAQFRDEYTLEDVLASPMIWGPLTRLQCCPPTCGAA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 237 AVVVCNAAGLKRLDGSRPIRILAAVLQSGTVRPLSAWDC------SVTRLAAQAAYEQAGVGPQDISVAEVHDASSFGEL 310
Cdd:PRK08256  219 AAIVCSEEFARKHGLDRAVEIVAQAMTTDTPSTFDGRSMidlvgyDMTRAAAQQVYEQAGIGPEDIDVVELHDCFSANEL 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 311 LQSELLGFCEIGSGGRFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCGARQVAGARIALAENGG 390
Cdd:PRK08256  299 LTYEALGLCPEGEAEKFIDDGDNTYGGRWVVNPSGGLLSKGHPLGATGLAQCAELTWQLRGTAGARQVEGARLALQHNLG 378
PRK06064 PRK06064
thiolase domain-containing protein;
6-406 6.40e-102

thiolase domain-containing protein;


Pssm-ID: 235688 [Multi-domain]  Cd Length: 389  Bit Score: 307.59  E-value: 6.40e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   6 VWIAGVGMTEFGVRPDVSVKELTRAAVVDALADAGADPTAIEAAYFGNTCQDVLEGQVVVAGQMALRSmGFERIPIVNVE 85
Cdd:PRK06064    4 VAIIGVGQTKFGELWDVSLRDLAVEAGLEALEDAGIDGKDIDAMYVGNMSAGLFVSQEHIAALIADYA-GLAPIPATRVE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  86 NACATGATALHQAIMHVRSGAADIVLAVGAEKLS---IGDKTKALGVFdggvdvNDRQgvravLEELGGALpedgkphsl 162
Cdd:PRK06064   83 AACASGGAALRQAYLAVASGEADVVLAAGVEKMTdvpTPDATEAIARA------GDYE-----WEEFFGAT--------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 163 FMDVYAALARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFRAEMSVEEILAARPVSGPLTVPMCAPLTDGASAVVVCN 242
Cdd:PRK06064  143 FPGLYALIARRYMHKYGTTEEDLALVAVKNHYNGSKNPYAQFQKEITVEQVLNSPPVADPLKLLDCSPITDGAAAVILAS 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 243 AAGLKRLDGSrPIRILAAVLQSGTV----RP----LSAwdcsvTRLAAQAAYEQAGVGPQDISVAEVHDASSFGELLQSE 314
Cdd:PRK06064  223 EEKAKEYTDT-PVWIKASGQASDTIalhdRKdfttLDA-----AVVAAEKAYKMAGIEPKDIDVAEVHDCFTIAEILAYE 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 315 LLGFCEIGSGGRFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRG--NCGARQVAGARIALAENGGGl 392
Cdd:PRK06064  297 DLGFAKKGEGGKLAREGQTYIGGDIPVNPSGGLKAKGHPVGATGVSQAVEIVWQLRGeaEKGRQQVIGAGYGLTHNVGG- 375

                         410
                  ....*....|....
gi 2755059532 393 yAGeeAAAAITILG 406
Cdd:PRK06064  376 -TG--HTAVVHILS 386
PRK12578 PRK12578
thiolase domain-containing protein;
4-391 2.61e-82

thiolase domain-containing protein;


Pssm-ID: 183606 [Multi-domain]  Cd Length: 385  Bit Score: 257.08  E-value: 2.61e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   4 MPVWIAGVGMTEFGVRPDVSVKELTRAavvdaladagADPTAIEAAyfGNTCQDVlegQVVVAGQMALRSMGFERIPIVN 83
Cdd:PRK12578    1 RRVAVIGVGNSKFGRRDDVSVQELAWE----------SIKEALNDA--GVSQTDI---ELVVVGSTAYRGIELYPAPIVA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  84 ------------VENACATGATALHQAIMHVRSGAADIVLAVGAEKLSIGDKTKALGVfdggvdvndrqGVRAvleelGG 151
Cdd:PRK12578   66 eysgltgkvplrVEAMCATGLAASLTAYTAVASGLVDMAIAVGVDKMTEVDTSTSLAI-----------GGRG-----GN 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 152 ALPEDGKPHSLFMDVYAALARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFRAEMSVEEILAARPVSGPLTVPMCAPL 231
Cdd:PRK12578  130 YQWEYHFYGTTFPTYYALYATRHMAVYGTTEEQMALVSVKAHKYGAMNPKAHFQKPVTVEEVLKSRAISWPIKLLDSCPI 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 232 TDGASAVVVCNAAGLKRLDGSRPIRILAAVLQSGT---VRPLSAWDCSVTRLAAQAAYEQAGVGPQDISVAEVHDASSFG 308
Cdd:PRK12578  210 SDGSATAIFASEEKVKELKIDSPVWITGIGYANDYayvARRGEWVGFKATQLAARQAYNMAKVTPNDIEVATVHDAFTIA 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 309 ELLQSELLGFCEIGSGGRFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCGARQVAGAR-IALAE 387
Cdd:PRK12578  290 EIMGYEDLGFTEKGKGGKFIEEGQSEKGGKVGVNLFGGLKAKGHPLGATGLSMIYEITKQLRDEAGKLQQPLKKyIGLVH 369


                  ....
gi 2755059532 388 NGGG 391
Cdd:PRK12578  370 NVGG 373
PRK06157 PRK06157
acetyl-CoA acetyltransferase; Validated
 6-407 2.84e-78

acetyl-CoA acetyltransferase; Validated


Pssm-ID: 180433 [Multi-domain]  Cd Length: 398  Bit Score: 247.25  E-value: 2.84e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   6 VWIAGVGMTEFGVRPDVSVKELTRAAVVDALADAGADPTAIEAAYFGnTCQDvlEGQVVVAGQMALRSMGFERIPIVNVE 85
Cdd:PRK06157    9 VAILGMGCTKFGERWDAGAEDLMVEAFLEALADAGIEPKDIDAAWFG-THYD--EIGSGKSGTPLSRALRLPNIPVTRVE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  86 NACATGATALHQAIMHVRSGAADIVLAVGAEKLSigdktkalgvfDGGvdvndRQG--VRAVLEELGGALPEDGKPHSlf 163
Cdd:PRK06157   86 NFCATGSEAFRGAVYAVASGAYDIALALGVEKLK-----------DTG-----YGGlpVANPGTLADMTMPNVTAPGN-- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 164 mdvYAALARAHMNAFGTTREQL----ALIASKNHEHAVHNPLAHFRAEMSVEEILAARPVSGPLTVPMCAPLTDGASAVV 239
Cdd:PRK06157  148 ---FAQLASAYAAKYGVSREDLkramAHVSVKSHANGARNPKAHLRKAVTEEQVLKAPMIAGPLGLFDCCGVSDGAAAAI 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 240 VCNAAGLKRLDGSRPIRILAAVLQSGTVRPL--SAWDCS---VTRLAAQAAYEQAGV-GPQ-DISVAEVHDASSFGELLQ 312
Cdd:PRK06157  225 VTTPEIARALGKKDPVYVKALQLAVSNGWELqyNGWDGSyfpTTRIAARKAYREAGItDPReELSMAEVHDCFSITELVT 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 313 SELLGFCEIGSGGRFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCGARQVAGARIALAENGGGL 392
Cdd:PRK06157  305 MEDLGLSERGQAWRDVLDGFFDADGGLPCQIDGGLKCFGHPIGASGLRMLYEMYLQLLGRAGERQLKNPRLALTHNLGGA 384

                         410
                  ....*....|....*
gi 2755059532 393 YAgeEAAAAITILGS 407
Cdd:PRK06157  385 PG--QNVCSVSIVGR 397
PRK07516 PRK07516
thiolase domain-containing protein;
4-391 2.49e-64

thiolase domain-containing protein;


Pssm-ID: 181013 [Multi-domain]  Cd Length: 389  Bit Score: 210.96  E-value: 2.49e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   4 MPVWIAGVGMTEFGVRPDVSVKELTRAAVVDALADAGADPTAIEAAYFGNTcQDVLEGQVVVAGQMALRSMGFERIPIVN 83
Cdd:PRK07516    2 MTASIVGWAHTPFGKLDAETLESLIVRVAREALAHAGIAAGDVDGIFLGHF-NAGFSPQDFPASLVLQADPALRFKPATR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  84 VENACATGATALHQAIMHVRSGAADIVLAVGAEKLSigdktkalgvfdggvdvndRQGVRAVLEELGGA--LPEDGKPHS 161
Cdd:PRK07516   81 VENACATGSAAVYAALDAIEAGRARIVLVVGAEKMT-------------------ATPTAEVGDILLGAsyLKEEGDTPG 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 162 LFMDVYAALARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFRAEMSVE---EILAARP-VSGPLTVPMCAPLTDGASA 237
Cdd:PRK07516  142 GFAGVFGRIAQAYFQRYGDQSDALAMIAAKNHANGVANPYAQMRKDLGFEfcrTVSEKNPlVAGPLRRTDCSLVSDGAAA 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 238 VVVCNAAGLKRLdgSRPIRILAAVlQSGTVRPLSAWDCSV---TRLAAQAAYEQAGVGPQDISVAEVHDASSFGELLQSE 314
Cdd:PRK07516  222 LVLADAETARAL--QRAVRFRARA-HVNDFLPLSRRDPLAfegPRRAWQRALAQAGVTLDDLSFVETHDCFTIAELIEYE 298

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2755059532 315 LLGFCEIGSGGRFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCGARQVAGARIALAENGGG 391
Cdd:PRK07516  299 AMGLAPPGQGARAIREGWTAKDGKLPVNPSGGLKAKGHPIGATGVSMHVLAAMQLTGEAGGMQIPGAKLAGVFNMGG 375
PRK06059 PRK06059
lipid-transfer protein; Provisional
 1-390 1.15e-63

lipid-transfer protein; Provisional


Pssm-ID: 180373 [Multi-domain]  Cd Length: 399  Bit Score: 209.23  E-value: 1.15e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   1 MTPMPVWIAGVGMTEFGVRPDVSVkELTRAAVVDALADAGADPTAIEAAYFGNTCQDVLEGqvVVAGQMALRSMGFERIP 80
Cdd:PRK06059    1 SMPEPVYILGAGMHPWGKWGRDFV-EYGVVAARAALADAGLDWRDVQLVVGADTIRNGYPG--FVAGATFAQALGWNGAP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  81 IVNVENACATGATALHQAIMHVRSGAADIVLAVGAEklsigdkTKALGVFD--GGVDVNDRQGVRAVLeeLGGALPedgk 158
Cdd:PRK06059   78 VSSSYAACASGSQALQSARAQILAGLCDVALVVGAD-------TTPKGFFApvGGERPDDPDWLRFHL--IGATNP---- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 159 phslfmdVYAAL-ARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFRAEMSVEEILAARPVSGPL-TVPMCApLTDGAS 236
Cdd:PRK06059  145 -------VYFALlARRRMDLYGATVEDFAQVKVKNARHGLLNPNARYRKEVTVEDVLASPVVSDPLrLLDICA-TSDGAA 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 237 AVVVCNAAGLKRLDGS--RPIRILAAVLQSGTVR------PLSAWDCSVTRLA---------AQAAYEQAGVGPQDISVA 299
Cdd:PRK06059  217 ALIVASKSFARRHLGSvaGVPSVRAISTVTPRYPqhlpelPDIATDSTAAVPApervfkdqiLDAAYAEAGIGPEDLSLA 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 300 EVHDASSFGELLQSELLGFCEIGSGGRFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCGARQVA 379
Cdd:PRK06059  297 EVYDLSTALELDWYEHLGLCPKGEAEALLRSGATTLGGRIPVNPSGGLACFGEAIPAQAIAQVCELTWQLRGQAGGRQVE 376

                         410
                  ....*....|.
gi 2755059532 380 GARIALAENGG 390
Cdd:PRK06059  377 GARVGITANQG 387
PRK06158 PRK06158
thiolase; Provisional
 158-407 2.64e-52

thiolase; Provisional


Pssm-ID: 180434 [Multi-domain]  Cd Length: 384  Bit Score: 179.07  E-value: 2.64e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 158 KPHSLFMDV--YAALARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFRAEMSVEEILAARPVSGPLTVPMCAPLTDGA 235
Cdd:PRK06158  133 APYKPVNPVsaYALAAARHMHQYGTTREQLAEVAVAARQWAQLNPEAFMRDPLTIDDVLAARMVSDPLSVRDCCLVTDGA 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 236 SAVVVCNAAGLKRLDGsRPIRILAAVLQSGTVRPLSAWDCSVT--RLAAQAAYEQAGVGPQDISVAEVHDASSFGELLQS 313
Cdd:PRK06158  213 GAVVMVRADRARDLPR-PPVYVLGAAAATWHRQISSMPDLTVTaaAESGPRAFAMAGLTPADIDVVELYDAFTINTILFL 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 314 ELLGFCEIGSGGRFAESGASRLGGRMPINPSGGLESKGHPmGASGLAQIYELVQQLRGNCGARQVAGARIALAE-NGGGL 392
Cdd:PRK06158  292 EDLGFCAKGEGGAFVEGGRIAPGGRLPVNTNGGGLSCVHP-GMYGLFLLIEAVRQLRGEAGERQVAGAEVALAHgNGGVL 370

                         250
                  ....*....|....*
gi 2755059532 393 yageeAAAAITILGS 407
Cdd:PRK06158  371 -----SSQATAILGT 380
nondecarbox_cond_enzymes cd00826
nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic ...
 9-392 2.10e-50

nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.


Pssm-ID: 238422 [Multi-domain]  Cd Length: 393  Bit Score: 174.60  E-value: 2.10e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   9 AGVGMTEFG--------VRPDVSvKELTRAAVVDALADAGADPTAIEAAYFGntcQDVLEGQVVVAGQMA-LRSMGFERI 79
Cdd:cd00826     1 AGAAMTAFGkfggengaDANDLA-HEAGAKAIAAALEPAGVAAGAVEEACLG---QVLGAGEGQNCAQQAaMHAGGLQEA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  80 PIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLSIGDKTKALgvfdggvdvndrQGVRAVLEELGGALPEDGKP 159
Cdd:cd00826    77 PAIGMNNLCGSGLRALALAMQLIAGGDANCILAGGFEKMETSAENNAK------------EKHIDVLINKYGMRACPDAF 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 160 HslfmdVYAALARAHMNAFGTTREQLALIASKN---HEHAVHNPLAHFRAEMSVEEILAARPV---SGPLTVPMCAPLTD 233
Cdd:cd00826   145 A-----LAGQAGAEAAEKDGRFKDEFAKFGVKGrkgDIHSDADEYIQFGDEASLDEIAKLRPAfdkEDFLTAGNACGLND 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 234 GASAVVVCNAAGLKRlDGSRPIRILAAVLQSGTVRPLSAWDCSVTRL--------AAQAAYEQAGVGPQDISVAEVHDAS 305
Cdd:cd00826   220 GAAAAILMSEAEAQK-HGLQSKAREIQALEMITDMASTFEDKKVIKMvggdgpieAARKALEKAGLGIGDLDLIEAHDAF 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 306 SFGELLQSELLGFCEIGSGGRFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCGARQVAGARIAL 385
Cdd:cd00826   299 AANACATNEALGLCPEGQGGALVDRGDNTYGGKSIINPNGGAIAIGHPIGASGAAICAELCFELKGEAGKRQGAGAGLAL 378


                  ....*..
gi 2755059532 386 AENGGGL 392
Cdd:cd00826   379 LCIGGGG 385
PRK06365 PRK06365
thiolase domain-containing protein;
5-405 2.79e-50

thiolase domain-containing protein;


Pssm-ID: 235785 [Multi-domain]  Cd Length: 430  Bit Score: 175.10  E-value: 2.79e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   5 PVWIAGVGMTEFG-VRPDVSVKELTRAAVVDALADAGADPTAIE---AAYFGNTCQDVLEGQVVVAGQMALRSMGFERIp 80
Cdd:PRK06365   17 DVYMVAAGVTKFDkASPYMDFRERVKKAFDYAMNDAGLTLADIDgsvASYFSDHFQRQLLAGIMVQDYLGLVPKPSKRI- 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  81 ivnvENACATGATALHQAIMHVRSGAADIVLAVGAEKLSIGDKTKALGVFDGGVDVNDRQgvravleELGGalpedgkph 160
Cdd:PRK06365   96 ----EGGGATGGLAFQAGYEEIASGRMDCVAVYGFETMSHVNTWKGNEFIALASDTNFDY-------PLGG--------- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 161 sLFMDVYAALARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFRAEMSVEEILAARPVSGPLTVPMCAPLTDGASAVVV 240
Cdd:PRK06365  156 -FYTGYYAMMAVRHMYEFGTTVEQLAKVSVKNHGNAIHNPFAQSPMKITVEDVRKSPMVSYPLTRLDVCAMSDGAACAIL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 241 CNAAGLKRLDgSRPIRILAAVLQSGTVRPLSAWDCSV------------------------TRLAAQAAYEQAGVGP--Q 294
Cdd:PRK06365  235 ASEDKAFEIT-DKPVLIKAIGTGSDTLRLADRPFGEVpllpnespddykdlrypgvhsfraGRMAAKEAYEMAGITDplN 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 295 DISVAEVHDASSFGELLQSELLGFCEIGSGGRFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCG 374
Cdd:PRK06365  314 DLDLIELHDAYTSSEIQTYEDLGLCKYGEGGQFIESGKPELPGKLPVNPSGGLLAAGHAVGATGIMQAVFMFWQLQGRIK 393

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 2755059532 375 AR------QVAGARIALAENggglYAGEEAAAAITIL 405
Cdd:PRK06365  394 KHfhddylQVKNAKRGLIHS----HAGTGTYVTVTIL 426
PRK06289 PRK06289
acetyl-CoA acetyltransferase; Provisional
 6-391 3.30e-41

acetyl-CoA acetyltransferase; Provisional


Pssm-ID: 235771 [Multi-domain]  Cd Length: 403  Bit Score: 150.22  E-value: 3.30e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   6 VWIAGVGMTEFG---VRPDVSVKELTRAAVVDALADAGADPTAIEAAYFGNTCQDVLEGQVVVAGQMALRSMGFERIPIV 82
Cdd:PRK06289    5 VWVLGGYQSDFArnwTKEGRDFADLTREVVDGTLAAAGVDADDIEVVHVGNFFGELFAGQGHLGAMPATVHPALWGVPAS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  83 NVENACATGATALHQAIMHVRSGAADIVLAVGAEKLSIGDKTKAlGVFDGGVDVNDRQGVRAvleelggalpedgkpHSL 162
Cdd:PRK06289   85 RHEAACASGSVATLAAMADLRAGRYDVALVVGVELMKTVPGDVA-AEHLGAAAWTGHEGQDA---------------RFP 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 163 FMDVYAALARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFR-----AEMSVEEILAARPVSGPLTVPMCAPLTDGASA 237
Cdd:PRK06289  149 WPSMFARVADEYDRRYGLDEEHLRAIAEINFANARRNPNAQTRgwafpDEATNDDDATNPVVEGRLRRQDCSQVTDGGAG 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 238 VVVCNAAGLKRLDGSRPI-RI-----------LAAVLQSGTVRP-LSAWdcsvTRLAAQAAYEQAGVGPQDISVAEVHDA 304
Cdd:PRK06289  229 VVLASDAYLRDYADARPIpRIkgwghrtaplgLEQKLDRSAGDPyVLPH----VRQAVLDAYRRAGVGLDDLDGFEVHDC 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 305 SSFGELLQSELLGFCEIGSGGRFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCGARQVAGARIA 384
Cdd:PRK06289  305 FTPSEYLAIDHIGLTGPGESWKAIENGEIAIGGRLPINPSGGLIGGGHPVGASGVRMLLDAAKQVTGTAGDYQVEGAKTF 384


                  ....*..
gi 2755059532 385 LAENGGG 391
Cdd:PRK06289  385 GTLNIGG 391
PRK08313 PRK08313
thiolase domain-containing protein;
2-391 6.82e-41

thiolase domain-containing protein;


Pssm-ID: 181378 [Multi-domain]  Cd Length: 386  Bit Score: 149.11  E-value: 6.82e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   2 TPMPVWIAGVGMTEF-GVRPDVSVKELTRAAVVDALADAGADPTAIEAAYFGNTcQDVLEGQVVVAGQMAlRSMGFERIP 80
Cdd:PRK08313    1 MKRLAAVLGTGQTKYvAKRQDVSMAGLVREAIDRALADAGLTWDDIDAVVVGKA-PDFFEGVMMPELFLA-DALGATGKP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  81 IVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLSIGDKTKALGV---FDGGVdvndrqGVRAvleelGGalpedg 157
Cdd:PRK08313   79 LIRVHTAGSVGGSTAVVAASLVQSGVYRRVLAVAWEKQSESNAMWALSIpvpFTKPV------GAGA-----GG------ 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 158 kphslfmdVYAALARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFR-AEMSVEEILAARPVSGPLTVPMCAPLTDGAS 236
Cdd:PRK08313  142 --------YFAPHVRAYIRRSGAPEHIGAMVAVKDRLNGAKNPYAHLHqPDITLEKVMASQMLWDPIRFDETCPSSDGAC 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 237 AVVVCNAAGLKRLDGSRPIRILAAVLQSGT--------VRPLSAwdcsvtRLAAQAAYEQAGV-GPQD-ISVAEVHDASS 306
Cdd:PRK08313  214 AVVIGDEEAADAAAGRPVAWIHGTAMRTEPlafagrdqVNPQAG------RDAAAALWKAAGItDPRDeIDVAEIYVPFS 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 307 FGELLQSELLGFCEIGSGGRFAESGASRLGGRMPINPSGGLESkGHPMGASGLAQIYELVQQLRGNCGARQVAGARIALA 386
Cdd:PRK08313  288 WFEPMWLENLGFAPEGEGWKLTEAGETAIGGRLPVNPSGGVLS-SNPIGASGMIRFAEAALQVMGKAGEHQVDGARKALG 366


                  ....*
gi 2755059532 387 ENGGG 391
Cdd:PRK08313  367 HAYGG 371
PTZ00455 PTZ00455
3-ketoacyl-CoA thiolase; Provisional
 73-380 4.14e-40

3-ketoacyl-CoA thiolase; Provisional


Pssm-ID: 240424 [Multi-domain]  Cd Length: 438  Bit Score: 148.12  E-value: 4.14e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  73 SMGFERIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLSIGDKTKALGVFDGGVDVNdRQgvrAVLEELgga 152
Cdd:PTZ00455  105 SNALLYKPAMRVEGACASGGLAVQSAWEALLAGTSDIALVVGVEVQTTVSARVGGDYLARAADYR-RQ---RKLDDF--- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 153 lpedgkphsLFMDVYAALARAHMNAFGTTREQLALIASKNHEHAVHNPLAH-FRAEMSVEEILAARPVSGP--------- 222
Cdd:PTZ00455  178 ---------TFPCLFAKRMKYIQEHGHFTMEDTARVAAKAYANGNKNPLAHmHTRKLSLEFCTGASDKNPKflgnetykp 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 223 -LTVPMCAPLTDGASAVVVCNAAGLKRL----DGSRPIRILAAVLQSGTV--RPLSAWDCSVTRLAAQAAYEQAGVGPQD 295
Cdd:PTZ00455  249 fLRMTDCSQVSDGGAGLVLASEEGLQKMglspNDSRLVEIKSLACASGNLyeDPPDATRMFTSRAAAQKALSMAGVKPSD 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 296 ISVAEVHDASSFGELLQSELLGFCEIGSGGRFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCGA 375
Cdd:PTZ00455  329 LQVAEVHDCFTIAELLMYEALGIAEYGHAKDLIRNGATALEGRIPVNTGGGLLSFGHPVGATGVKQIMEVYRQMKGQCGE 408


                  ....*
gi 2755059532 376 RQVAG 380
Cdd:PTZ00455  409 YQMKN 413
PRK08142 PRK08142
thiolase domain-containing protein;
166-406 1.13e-38

thiolase domain-containing protein;


Pssm-ID: 236164 [Multi-domain]  Cd Length: 388  Bit Score: 142.92  E-value: 1.13e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 166 VYAALARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFRAEMSVEEILAARPVSGPLTVPMCAPLTDGASAVVVCN--- 242
Cdd:PRK08142  145 LYAMCAMRHMHEYGTTSEQLAWIKVAASHHAQHNPHAMLRDVVTVEDVLNSPMIADPLHRLDCCVVTDGGGALVVVRpei 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 243 AAGLKrldgsRP-IRILAAvlqSGTVRPLSAWDCSVTRLAAQ----AAYEQAGVGPQDISVAEVHDASSFGELLQSELLG 317
Cdd:PRK08142  225 ARSLK-----RPlVKVLGA---GEAIKGQMGGKVDLTYSGAAwsgpAAFAEAGVTPADIKYASIYDSFTITVLMQLEDLG 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 318 FCEIGSGGRFAESGASRLG-GRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCG-ARQVAGARIALAENGGGLYAG 395
Cdd:PRK08142  297 FCKKGEGGKFVADGNLISGvGKLPFNTDGGGLCNNHPANRGGMTKVIEAVRQLRGEAHpAVQVPNCDLALAHGTGGLLGS 376

                         250
                  ....*....|.
gi 2755059532 396 EEAAAAItILG 406
Cdd:PRK08142  377 RHGSATL-ILE 386
PRK06066 PRK06066
thiolase domain-containing protein;
4-386 2.67e-37

thiolase domain-containing protein;


Pssm-ID: 180380 [Multi-domain]  Cd Length: 385  Bit Score: 139.12  E-value: 2.67e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   4 MPVWIAGVGMteFGVRP---DVSVKELTRAAVVDALADAGA-DPTAIEAAYFgnTCQ-DVLEGqVVVAGQMALRSMGFER 78
Cdd:PRK06066    4 NRVAIVGIGW--YGFRPttpEVSFREMMFEAASRAYKDAGNiNPRRDVDSFI--SCQeDFWEG-IAIADEFAPDQIGGAM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  79 IPIVNVenaCATGATALHQAIMHVRSGAADIVLAVGAEK----LSIGDKTK-ALgvfdggvdvnDRQGVRAVleelggal 153
Cdd:PRK06066   79 RPTMTV---AGDGLQGLAHAVMHINSGLANVVVVEAHSKpsdiLTFSDVVKfAM----------DPIYVRPI-------- 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 154 pedGKPHSLFMdvyAAL-ARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFRAEMSVEEILAARPVSGPLTVPMCAPLT 232
Cdd:PRK06066  138 ---GPPNPHFI---AGLdAVKFMSRKGITREDLALVVEKNKKAGLSNPRASYASNISLEDVLSSEYVVYPLTELDIAPFV 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 233 DGASAVVVCNAAGLKRL-DGSRPIRILAAVLQSGTVRPLSAWDCSVTRLAAQAAYEQAGVG-PQ-DISVAEVHDASSFGE 309
Cdd:PRK06066  212 DGAIVVVLASEEVAKKLtDDPVWIKGIGWSTESSNLETAELGKANYMRIAADMAYKMAGIEsPRkEVDAAEVDDRYSYKE 291

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2755059532 310 LLQSELLGFCEIGSGGRFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCGARQVaGARIALA 386
Cdd:PRK06066  292 LQHIEALRLSEEPEKDSLLREGNFDPQGELPVNPSGGHLAKGVPLEASGLSLLLDAVEYLRGEAGARQG-KAERAVV 367
PRK07855 PRK07855
lipid-transfer protein; Provisional
 87-391 3.68e-33

lipid-transfer protein; Provisional


Pssm-ID: 181147 [Multi-domain]  Cd Length: 386  Bit Score: 128.17  E-value: 3.68e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  87 ACATgataLHQAIMHVRSGAADIVLAVGAeklsigdktkalgvfdggvdVNDRQGVR-----AVLEELGGALPEDGK--- 158
Cdd:PRK07855   84 ACAT----VQQAAMAVATGVADVVVCYRA--------------------FNERSGMRfgqgqTGLAENPTSTGVDYGwsy 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 159 PHSLF--MDVYAALARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFRAE-MSVEEILAARPVSGPLTVPMCAPLTDGA 235
Cdd:PRK07855  140 PHGLLtpAAWVAMLARRYMHEYGATSEDFGRVAVADRKHAATNPKAWFYGRpITLEDHQNSRWIAEPLRLLDCCQESDGA 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 236 SAVVVCNAAGLKRLdGSRPIRILAAVLQSGT------------VRPLSAWDcsvtrLAAQAAYEQAGVGPQDISVAEVHD 303
Cdd:PRK07855  220 VALVVTSAERARDL-KQRPAVIKAAAQGSGAdqymmtsyyrddITGLPEMG-----LVARQLWAQSGLGPADIDTAILYD 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 304 ASSFGELLQSELLGFCEIGSGGRFAESGASRLGGRMPINPSGGLESKGHPMGASGLAqiyELVQQLRGNcGARQVAGARI 383
Cdd:PRK07855  294 HFTPFVLMQLEELGFCGRGEAKDFIADGALELGGRLPINTHGGQLGEAYIHGMNGIA---EAVRQLRGT-SVNQVPGVEN 369


                  ....*...
gi 2755059532 384 ALAENGGG 391
Cdd:PRK07855  370 VLVTAGTG 377
PRK06065 PRK06065
thiolase domain-containing protein;
6-379 6.98e-29

thiolase domain-containing protein;


Pssm-ID: 180379 [Multi-domain]  Cd Length: 392  Bit Score: 116.46  E-value: 6.98e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   6 VWIAGVGMTEFGVRPDVSVKELTRAAVVDALADAGADPTAIEAAYFGnTCQDVLEGqVVVAGQMALRSMGFERIPIVNVE 85
Cdd:PRK06065   11 VAVIGAGLTLFRRRLLETPQELAWEAASKALDEAGLELKDIDCVVIG-SAPDAFDG-VHMKGEYLSHGSGGIRKPVSRVY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  86 NACATGATALHQAIMHVRSGAADIVLAVGAEKLSiGDKTKALGVFdggvdvndrqgvRAVLEELggaLPEDGKPHSLFmd 165
Cdd:PRK06065   89 VGGATGVMTAIAGWYHVASGLCQKVLAVAEEKMS-PARPHPQAVF------------RYIWDPI---LEKPLNPNLIW-- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 166 VYAALARAHMNAFGTTREQLALIASKNHEHAVHNPLAHFRAEMSVEEILAARPVSGPLTVPMCAPLTDGASAVVVCNAAG 245
Cdd:PRK06065  151 IFAMEMHRYMATYGIKKEEIALVSVKNKRNALNNPYAQLGSKITVEDVLKSEVLVWPVQLLDVSPVSDGAAAIVLASEDL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 246 LKRLDGSrPIRILAAvlqsGTVRPLSAW---DCSVTRL---AAQAAYEQAGV-GPQ-DISVAEVHDASSFGELLQSELLG 317
Cdd:PRK06065  231 ARRYTDT-PVWVEGV----GWTLDNTEWpnrDLAYPRYvefAARMAYKMAGIeRPRkEIDVAEPYDPFDYKELHHLEGLQ 305

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2755059532 318 FCEIGSGGRFAESGASRLGGRMPINPSGGLESKGHPMGASGLAQIYELVQQLRGNCGARQVA 379
Cdd:PRK06065  306 LAKRGEAPKLLKEGVFDIDGDIPSSPSGGLLGVGNPIAAAGLMKVISIYWQLKGTAGKMQVK 367
PRK07937 PRK07937
lipid-transfer protein; Provisional
 91-381 3.16e-17

lipid-transfer protein; Provisional


Pssm-ID: 181173 [Multi-domain]  Cd Length: 352  Bit Score: 82.43  E-value: 3.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  91 GATALHQAIMHVRSGAADIVLAVGAEKLSIGDKTKALGvfdggvdvndRQGVRAVLEELGgalpedgkPHSLFMdvyAAL 170
Cdd:PRK07937   86 AAWALYEAWVKLLTGEVDTALVYGFGKSSAGTLRRVLA----------LQLDPYTVAPLW--------PDSVSM---AGL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 171 -ARAHMNAFGTTREQLALIASKNHEHAVHNPlaHFRAEMSVEEILAARPVSGPLTVPMCAPLTDGASAVVVcnAAGlkrl 249
Cdd:PRK07937  145 qARAGLDAGKWTEEQMAEVAARSRADARRNP--SAEPSISVDELLARPYFADPLRRHDIAPITDGAAAVVL--AAG---- 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 250 DGSRPIRILAAVLQSGTVR----PLSAWDCSV---TRLAAQAAyeqAGVGPQDISVAEVHDASSFGELLQSELLGfceig 322
Cdd:PRK07937  217 DRARELRERPAWITGIEHRiespSLGARDLTRspsTALAAEAA---TGGDAGGVDVAELHAPFTHQELILREALG----- 288

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 323 sggrfaesgasrLGGRMPINPSGGlESKGHPMGASGLAQIYELVQQ-LRGNCGaRQVAGA 381
Cdd:PRK07937  289 ------------LGDKTKVNPSGG-ALAANPMFAAGLERIGEAARHiWDGSAR-RALAHA 334
thiolase cd00751
Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of ...
 40-402 8.43e-16

Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.


Pssm-ID: 238383 [Multi-domain]  Cd Length: 386  Bit Score: 78.29  E-value: 8.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  40 GADPTAIEAAYFGNTCQdVLEGQVVvAGQMALRSmGF-ERIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKL 118
Cdd:cd00751    38 GLDPEEVDDVIMGNVLQ-AGEGQNP-ARQAALLA-GLpESVPATTVNRVCGSGLQAVALAAQSIAAGEADVVVAGGVESM 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 119 SigdktKALGVFDGGVDVNDRQGVRAVLEELGGALPEDGKPHslfMDVYA-ALARAH------MNAFGTTREQLALIASK 191
Cdd:cd00751   115 S-----RAPYLLPKARRGGRLGLNTLDGMLDDGLTDPFTGLS---MGITAeNVAEKYgisreeQDEFALRSHQRAAAAQE 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 192 N---------------HEHAVHNPLAHFRAEMSVEEILAARPV---SGPLTVPMCAPLTDGASAVVVCNAAGLKRLDgsr 253
Cdd:cd00751   187 AgrfkdeivpvevpgrKGPVVVDRDEGPRPDTTLEKLAKLKPAfkkDGTVTAGNASGINDGAAAVLLMSEEKAKELG--- 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 254 pIRILAAVLQSGTVRplsawdCSVTRL------AAQAAYEQAGVGPQDISVAEVHDASSFGELLQSELLGFceigsggrf 327
Cdd:cd00751   264 -LKPLARIVGYAVAG------VDPAIMgigpvpAIPKALKRAGLTLDDIDLIEINEAFAAQALACLKELGL--------- 327

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2755059532 328 aesGASRLggrmpiNPSGGLESKGHPMGASGLAQIYELVQQLRGNcgarqvaGARIALAE--NGGGLyageeAAAAI 402
Cdd:cd00751   328 ---DPEKV------NVNGGAIALGHPLGASGARIVVTLLHELKRR-------GGRYGLATmcIGGGQ-----GAAMV 383
Thiolase_N pfam00108
Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl ...
 6-244 9.12e-16

Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.


Pssm-ID: 459676 [Multi-domain]  Cd Length: 260  Bit Score: 76.57  E-value: 9.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532   6 VWIAGVGMTEFG----VRPDVSVKELTRAAVVDALADAGADPTAIEAAYFGNTCQDVlEGQVVvAGQMALRSMGFERIPI 81
Cdd:pfam00108   1 VVIVSAARTPFGsfggSLKDVSAVELGAEAIKAALERAGVDPEDVDEVIVGNVLQAG-EGQNP-ARQAALKAGIPDSAPA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  82 VNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLSIGDKtkalgvfdgGVDVNDRQGVRAVLEELGGALPEDGkPHS 161
Cdd:pfam00108  79 VTINKVCGSGLKAVYLAAQSIASGDADVVLAGGVESMSHAPY---------ALPTDARSGLKHGDEKKHDLLIPDG-LTD 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 162 LFMDVYAAL-ARAHMNAFGTTREQLALIASKNHEHAVHNPLA-HFRAEM-----------------------SVEEILAA 216
Cdd:pfam00108 149 AFNGYHMGLtAENVAKKYGISREEQDAFAVKSHQKAAAAPKAgKFKDEIvpvtvkgrkgkptvdkdegirppTTAEPLAK 228

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2755059532 217 -RPV---SGPLTVPMCAPLTDGASAVVVCNAA 244
Cdd:pfam00108 229 lKPAfdkEGTVTAGNASPINDGAAAVLLMSES 260
PRK08235 PRK08235
acetyl-CoA C-acetyltransferase;
57-391 4.58e-09

acetyl-CoA C-acetyltransferase;


Pssm-ID: 181311 [Multi-domain]  Cd Length: 393  Bit Score: 57.80  E-value: 4.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  57 DVLEGQVVVAGQ------MALRSMGFE-RIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLS---------- 119
Cdd:PRK08235   50 EVIMGTVLQGGQgqipsrQAARAAGIPwEVQTETVNKVCASGLRAVTLADQIIRAGDASVIVAGGMESMSnapyilpgar 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 120 ----IGDKT-KALGVFDG------GVDVNDRQGVRAvlEELGGALPEdgkphslfMDVYAAlaRAHMNAF-----GTTRE 183
Cdd:PRK08235  130 wgyrMGDNEvIDLMVADGltcafsGVHMGVYGGEVA--KELGISREA--------QDEWAY--RSHQRAVsaheeGRFEE 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 184 QL---ALIASKNHEHAVHNPLAhFRAEMSVEEILAARPV---SGPLTVPMCAPLTDGASAVVVCNAAGLKRLdGSRPiri 257
Cdd:PRK08235  198 EIvpvTIPQRKGDPIVVAKDEA-PRKDTTIEKLAKLKPVfdkTGTITAGNAPGVNDGAAALVLMSEDRAKQE-GRKP--- 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 258 LAAVLQSGTVrPLSAWDCSVTR-LAAQAAYEQAGVGPQDISVAEVHDASSFGELLQSELLGFceigsggrfaesgasrlg 336
Cdd:PRK08235  273 LATILAHTAI-AVEAKDFPRTPgYAINALLEKTGKTVEDIDLFEINEAFAAVALASTEIAGI------------------ 333

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2755059532 337 GRMPINPSGGLESKGHPMGASGLAQIYELVQQLRgncgaRQVAGARIALAENGGG 391
Cdd:PRK08235  334 DPEKVNVNGGAVALGHPIGASGARIIVTLIHELK-----RRGGGIGIAAICSGGG 383
PaaJ COG0183
Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is ...
 40-304 4.61e-09

Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 439953 [Multi-domain]  Cd Length: 391  Bit Score: 57.77  E-value: 4.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  40 GADPTAIEAAYFGNTCQdVLEGQVVvAGQMALRSmGF-ERIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKL 118
Cdd:COG0183    42 GLDPEAVDDVILGCVLQ-AGQGQNP-ARQAALLA-GLpESVPAVTVNRVCGSGLQAVALAAQAIAAGDADVVIAGGVESM 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 119 SigdkTKALGVFDGgvdvndRQGVRAvleelgGALPEDGKPHSLFMDVYAALaraHM--------NAFGTTREQLALIAS 190
Cdd:COG0183   119 S----RAPMLLPKA------RWGYRM------NAKLVDPMINPGLTDPYTGL---SMgetaenvaERYGISREEQDAFAL 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 191 KNHEHA---------------VHNPLA----------HFRAEMSVEEILAARPV---SGPLTVPMCAPLTDGASAVVVCN 242
Cdd:COG0183   180 RSHQRAaaaiaagrfddeivpVEVPDRkgevvvdrdeGPRPDTTLEKLAKLKPAfkkDGTVTAGNASGINDGAAALLLMS 259

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2755059532 243 AAGLKRLDgsrpIRILAAVLQSGTVRplsawdCSVTRL------AAQAAYEQAGVGPQDISVAEVHDA 304
Cdd:COG0183   260 EEAAKELG----LKPLARIVAYAVAG------VDPEIMgigpvpATRKALARAGLTLDDIDLIEINEA 317
PRK06504 PRK06504
acetyl-CoA C-acetyltransferase;
40-370 1.16e-08

acetyl-CoA C-acetyltransferase;


Pssm-ID: 180595 [Multi-domain]  Cd Length: 390  Bit Score: 56.66  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  40 GADPTAIEAAYFGNTCQdVLEGQVVVAGQMALRSMGFERIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLS 119
Cdd:PRK06504   42 GADPALIEDVIMGCVSQ-VGEQATNVARNAVLASKLPESVPGTSIDRQCGSSQQALHFAAQAVMSGTMDIVIAAGVESMT 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 120 igdktkalgvfdggvdvndrqgvrAVLEELGGALPED---GKPHSLFMD------VYAALARAHMNA--FGTTREQLALI 188
Cdd:PRK06504  121 ------------------------RVPMGSPSTLPAKnglGHYKSPGMEerypgiQFSQFTGAEMMAkkYGLSKDQLDEF 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 189 ASKNHEHAVHNPLA-HFRAEM-------------------------SVEEILAARPVS--GPLTVPMCAPLTDGASAVVV 240
Cdd:PRK06504  177 ALQSHQRAIAATQAgKFKAEIvpleitradgsgemhtvdegirfdaTLEGIAGVKLIAegGRLTAATASQICDGASGVMV 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 241 CNAAGLKRLdGSRPI-RIL-AAVLQSGTVRPLSAwdcsvTRLAAQAAYEQAGVGPQDISVAEVHDASSFGELLQSELLGf 318
Cdd:PRK06504  257 VNERGLKAL-GVKPLaRIHhMTVIGGDPVIMLEA-----PLPATERALKKAGMKIDDIDLYEVNEAFASVPLAWLKATG- 329

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2755059532 319 ceigsggrfaeSGASRLggrmpiNPSGGLESKGHPMGASGLAQIYELVQQLR 370
Cdd:PRK06504  330 -----------ADPERL------NVNGGAIALGHPLGASGTKLMTTLVHALK 364
cond_enzymes cd00327
Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) ...
 65-391 1.61e-08

Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the production of polyketides, a diverse group of natural products.


Pssm-ID: 238201 [Multi-domain]  Cd Length: 254  Bit Score: 55.14  E-value: 1.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  65 VAGQMALRSmGFERIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLSIGDKTKAlgvfdggvdvndrqgvrA 144
Cdd:cd00327    46 AAGQLAYHL-GISGGPAYSVNQACATGLTALALAVQQVQNGKADIVLAGGSEEFVFGDGAAA-----------------A 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 145 VLEELggalpedgkphslfmdvyaALARAHmnafgttreqlaliasknhehavhnplahfraemsvEEILAARPVSGPLT 224
Cdd:cd00327   108 VVESE-------------------EHALRR------------------------------------GAHPQAEIVSTAAT 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 225 VpmcapltDGASAVVVCNAAGLKRldgsrpirilaavlqsgtvrplsawdcsvtrlAAQAAYEQAGVGPQDISVAEVHDA 304
Cdd:cd00327   133 F-------DGASMVPAVSGEGLAR--------------------------------AARKALEGAGLTPSDIDYVEAHGT 173

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 305 SSFGELLQSELLGFCEIGSGGrfaesgasrlggrmpINPSGGLESKGHPMGASGLAQIYELVQQLRGNCGARQVAGARIA 384
Cdd:cd00327   174 GTPIGDAVELALGLDPDGVRS---------------PAVSATLIMTGHPLGAAGLAILDELLLMLEHEFIPPTPREPRTV 238


                  ....*..
gi 2755059532 385 LAENGGG 391
Cdd:cd00327   239 LLLGFGL 245
PLN02644 PLN02644
acetyl-CoA C-acetyltransferase
 40-391 8.31e-08

acetyl-CoA C-acetyltransferase


Pssm-ID: 215347 [Multi-domain]  Cd Length: 394  Bit Score: 53.94  E-value: 8.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  40 GADPTAIEAAYFGNTCQDVLeGQVVvAGQMALRSMGFERIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLS 119
Cdd:PLN02644   41 GVDPALVQEVFFGNVLSANL-GQAP-ARQAALGAGLPPSTICTTVNKVCASGMKAVMLAAQSIQLGINDVVVAGGMESMS 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 120 IGDKTKAlgvfdggvdvNDRQGVRavleeLGGALPEDGKPHSLFMDVYAALAR---AHMNA--FGTTREQLALIASKNHE 194
Cdd:PLN02644  119 NAPKYLP----------EARKGSR-----LGHDTVVDGMLKDGLWDVYNDFGMgvcAELCAdqYSISREEQDAYAIQSYE 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 195 HAVH-NPLAHFRAE-------------------------MSVEEILAARPV----SGPLTVPMCAPLTDGASAVVVCNAA 244
Cdd:PLN02644  184 RAIAaQEAGAFAWEivpvevpggrgrpsvivdkdeglgkFDPAKLRKLRPSfkedGGSVTAGNASSISDGAAALVLVSGE 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 245 GLKRLDgsrpIRILAAVLQSGTVRPLSAWDCSVTRLAAQAAYEQAGVGPQDISVAEVHDASSFGELLQSELLGFceigsg 324
Cdd:PLN02644  264 KALELG----LQVIAKIRGYADAAQAPELFTTAPALAIPKALKHAGLEASQVDYYEINEAFSVVALANQKLLGL------ 333

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2755059532 325 grfaesGASRLggrmpiNPSGGLESKGHPMGASGLAQIYELVQQLRGNCGARQVAGARialaeNGGG 391
Cdd:PLN02644  334 ------DPEKV------NVHGGAVSLGHPIGCSGARILVTLLGVLRSKNGKYGVAGIC-----NGGG 383
PRK08257 PRK08257
acetyl-CoA acetyltransferase; Validated
 95-301 4.23e-06

acetyl-CoA acetyltransferase; Validated


Pssm-ID: 236204 [Multi-domain]  Cd Length: 498  Bit Score: 48.76  E-value: 4.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  95 LHQAIMHVRSGAADIVLAVGAEKLSIGDKTKALGVFDGGVDVNDRQGVRAVLEELGGALPEDGKpHSLF--MDVYAALAR 172
Cdd:PRK08257   96 VNEAALRIAAGEADVALVAGAEAQSTATKLRKAGEKLDWTPQDEGPLADRGGDPRPMASPAELR-HGLDrpVYVYPLFEN 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 173 AHMNAFG-TTREQLALIA---SKNHEHAVHNPLAHFRAEMSVEEILAA----RPVSGPLTVPMCA-PLTDGASAVVVCNA 243
Cdd:PRK08257  175 ALRAALGrSPEEHRAEMGelwAPFSAVAAKNPHAWIPRERSAEEIVTPtpdnRMIAWPYTKLMNAnDMVDQGAAVLLTSV 254

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2755059532 244 AGLKRL--DGSRPIRILAAVLQSGTVRPLSAWDCSVT---RLAAQAAYEQAGVGPQDISVAEV 301
Cdd:PRK08257  255 AKARRLgvPEDRWVYLHGGADAHDPYDILERPDLHRSpaiRAAGRRALALAGLGIDDIDAFDL 317
PRK06205 PRK06205
acetyl-CoA C-acetyltransferase;
17-358 5.04e-06

acetyl-CoA C-acetyltransferase;


Pssm-ID: 235741 [Multi-domain]  Cd Length: 404  Bit Score: 48.45  E-value: 5.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  17 GVRPDVSVKELTRAAVVDALADAGADPTAIEAAYFGntcQDVLEGQVVVAGQMALRSMGF-ERIPIVNVENACATGATAL 95
Cdd:PRK06205   19 GAFKDVPAEELAATVIRALVERTGIDPARIDDVIFG---QGYPNGEAPAIGRVAALDAGLpVTVPGMQLDRRCGSGLQAV 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  96 HQAIMHVRSGAADIVLAVGAEKLS-IGDKTKAL--GVFDGGVDVNDR--------QGVRAVLEelGGALpedgkphslfm 164
Cdd:PRK06205   96 ITAAMQVQTGAADVVIAGGAESMSnVEFYTTDMrwGVRGGGVQLHDRlargretaGGRRFPVP--GGMI----------- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 165 DVYAALARAhmnaFGTTREQLALIASKNHEHAVH---------------------NPLA-----HFRAEMSVEEILAARP 218
Cdd:PRK06205  163 ETAENLRRE----YGISREEQDALAVRSHQRAVAaqeagrfddeivpvtvpqrkgDPTVvdrdeHPRADTTLESLAKLRP 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 219 V------SGPLTVPMCAPLTDGASAVVVCNAAGLKRLdGSRPIrilaavlqsGTVRPLSAWDCSVTRL------AAQAAY 286
Cdd:PRK06205  239 ImgkqdpEATVTAGNASGQNDAAAACLVTTEDKAEEL-GLRPL---------ARLVSWAVAGVEPSRMgigpvpATEKAL 308

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2755059532 287 EQAGVGPQDISVAEVHDAssfgelLQSELLGfceIGSGGRFAESGASRLggrmpiNPSGGLESKGHPMGASG 358
Cdd:PRK06205  309 ARAGLTLDDIDLIELNEA------FAAQVLA---VLKEWGFGADDEERL------NVNGSGISLGHPVGATG 365
PRK07851 PRK07851
acetyl-CoA C-acetyltransferase;
74-358 3.36e-05

acetyl-CoA C-acetyltransferase;


Pssm-ID: 181146 [Multi-domain]  Cd Length: 406  Bit Score: 45.76  E-value: 3.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  74 MGFERIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLSIGDKTKALG-------VFDggvDVNDRQGVRAvl 146
Cdd:PRK07851   76 LGYDFLPGTTVNRYCSSSLQTTRMAFHAIKAGEGDVFISAGVETVSRFAKGNSDSlpdtknpLFA---EAQARTAARA-- 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 147 eELGGALPEDGKPHSLFMDVYAAL-------------ARAHMNAFGTTREQLALIASKNHEHA------------VHNPL 201
Cdd:PRK07851  151 -EGGAEAWHDPREDGLLPDVYIAMgqtaenvaqltgiSREEQDEWGVRSQNRAEEAIANGFFEreitpvtlpdgtVVSTD 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 202 AHFRAEMSVEEILAARPV---SGPLTVPMCAPLTDGASAVVVCNAAGLKRLdGSRPiriLAAVLQSGtvrpLSAWDCSVT 278
Cdd:PRK07851  230 DGPRAGTTYEKVSQLKPVfrpDGTVTAGNACPLNDGAAAVVIMSDTKAREL-GLTP---LARIVSTG----VSGLSPEIM 301

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 279 RL----AAQAAYEQAGVGPQDISVAEVHDASSFGELLQSELLGFCEigsggrfaesgaSRLggrmpiNPSGGLESKGHPM 354
Cdd:PRK07851  302 GLgpveASKQALARAGMSIDDIDLVEINEAFAAQVLPSARELGIDE------------DKL------NVSGGAIALGHPF 363


                  ....
gi 2755059532 355 GASG 358
Cdd:PRK07851  364 GMTG 367
PRK06366 PRK06366
acetyl-CoA C-acetyltransferase;
40-391 3.76e-05

acetyl-CoA C-acetyltransferase;


Pssm-ID: 102340 [Multi-domain]  Cd Length: 388  Bit Score: 45.39  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  40 GADPTAIEAAYFGNtcqdVLEGQV--VVAGQMALRSMGFERIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEK 117
Cdd:PRK06366   42 KLDPALVQEVIMGN----VIQAGVgqNPAGQAAYHAGLPFGVTKYTVNVVCASGMLAVESAAREIMLGERDLVIAGGMEN 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 118 LSIGDKTkalgvfdggVDVNDRQGVRAVLE---ELGGALPEDGKPHSLFMDVYAALARAHMNAFGTTREQLALIASKNHE 194
Cdd:PRK06366  118 MSNAPFL---------LPSDLRWGPKHLLHknyKIDDAMLVDGLIDAFYFEHMGVSAERTARKYGITREMADEYSVQSYE 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 195 HAVH-NPLAHFRAEM---------------SVEEILAARPV---SGPLTVPMCAPLTDGASAVVVCNAAGLKRLdGSRPI 255
Cdd:PRK06366  189 RAIRaTESGEFRNEIvpfndldrdegirktTMEDLAKLPPAfdkNGILTAGNSAQLSDGGSALVMASEKAINEY-GLKPI 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 256 RILAAvLQSGTVRPLSAWDCSVTrlAAQAAYEQAGVGPQDISVAEVHDASSFGELLQSELLGFceigSGGRFaesgasrl 335
Cdd:PRK06366  268 ARITG-YESASLDPLDFVEAPIP--ATRKLLEKQNKSIDYYDLVEHNEAFSIASIIVRDQLKI----DNERF-------- 332

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2755059532 336 ggrmpiNPSGGLESKGHPMGASGLAQIYELVQQLRgncgARQVAGARIALAENGGG 391
Cdd:PRK06366  333 ------NVNGGAVAIGHPIGNSGSRIIVTLINALK----TRHMKTGLATLCHGGGG 378
FabB COG0304
3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary ...
 65-116 1.01e-04

3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; 3-oxoacyl-(acyl-carrier-protein) synthase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440073 [Multi-domain]  Cd Length: 409  Bit Score: 44.32  E-value: 1.01e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2755059532  65 VAGQMALRsMGFeRIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAE 116
Cdd:COG0304   140 AAGHVSIR-FGL-KGPNYTVSTACASGAHAIGEAYRLIRRGRADVMIAGGAE 189
ketoacyl-synt pfam00109
Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar ...
 64-116 2.93e-04

Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine.


Pssm-ID: 425468 [Multi-domain]  Cd Length: 251  Bit Score: 42.24  E-value: 2.93e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2755059532  64 VVAGQMALRsMGFeRIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAE 116
Cdd:pfam00109 151 VIAGRISYF-LGL-RGPSVTVDTACSSSLVAIHAAVQSIRSGEADVALAGGVN 201
KAS_I_II cd00834
Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible ...
 80-119 3.47e-04

Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.


Pssm-ID: 238430 [Multi-domain]  Cd Length: 406  Bit Score: 42.53  E-value: 3.47e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2755059532  80 PIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLS 119
Cdd:cd00834   153 PNYTVSTACASGAHAIGDAARLIRLGRADVVIAGGAEALI 192
decarbox_cond_enzymes cd00825
decarboxylating condensing enzymes; Family of enzymes that catalyze the formation of a new ...
 84-265 8.83e-04

decarboxylating condensing enzymes; Family of enzymes that catalyze the formation of a new carbon-carbon bond by a decarboxylating Claisen-like condensation reaction. Members are involved in the synthesis of fatty acids and polyketides, a diverse group of natural products. Both pathways are an iterative series of additions of small carbon units, usually acetate, to a nascent acyl group. There are 2 classes of decarboxylating condensing enzymes, which can be distinguished by sequence similarity, type of active site residues and type of primer units (acetyl CoA or acyl carrier protein (ACP) linked units).


Pssm-ID: 238421 [Multi-domain]  Cd Length: 332  Bit Score: 41.08  E-value: 8.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  84 VENACATGATALHQAIMHVRSGAADIVLAVGAEKLS-----IGDKTKALGVFDGGVDVNDRQGVRAVLEELGGALPEDGK 158
Cdd:cd00825    92 VSAACAGSLHALSLAADAVQNGKQDIVLAGGSEELAapmdcEFDAMGALSTPEKASRTFDAAADGFVFGDGAGALVVEEL 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 159 PHSLFM--DVYAALARAHMNAFGTTREQLAlIASKNHEHAVHNPLAhfRAEMSVEEIL------AARPVSGPLTVPMCAP 230
Cdd:cd00825   172 EHALARgaHIYAEIVGTAATIDGAGMGAFA-PSAEGLARAAKEALA--VAGLTVWDIDylvahgTGTPIGDVKELKLLRS 248

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2755059532 231 LTDGASAVVVCNAAGLKRLDGSRPIRILAAVLQSG 265
Cdd:cd00825   249 EFGDKSPAVSATKAMTGNLSSAAVVLAVDEAVLML 283
init_cond_enzymes cd00827
"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, ...
 40-202 9.71e-04

"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the utlization of CoA substrate primers, as well as the nature of their active site residues.


Pssm-ID: 238423 [Multi-domain]  Cd Length: 324  Bit Score: 40.88  E-value: 9.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  40 GADPTAIEAAYFG-NTCQDVLEGQVVVAGQMalrsMGFERIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKL 118
Cdd:cd00827    64 GIDPDDIGLLIVAtESPIDKGKSAATYLAEL----LGLTNAEAFDLKQACYGGTAALQLAANLVESGPWRYALVVASDIA 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 119 SIGDKTKALGVFDGG-------VDVNDRQGVRAVLEELGGALPEDGKPHSLFMDVYAALARAHMNAFGTTREQ----LAL 187
Cdd:cd00827   140 SYLLDEGSALEPTLGdgaaamlVSRNPGILAAGIVSTHSTSDPGYDFSPYPVMDGGYPKPCKLAYAIRLTAEPagraVFE 219

                         170
                  ....*....|....*
gi 2755059532 188 IASKNHEHAVHNPLA 202
Cdd:cd00827   220 AAHKLIAKVVRKALD 234
ACP_syn_III pfam08545
3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; This domain is found on 3-Oxoacyl- ...
 84-119 1.50e-03

3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; This domain is found on 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III EC:2.3.1.180, the enzyme responsible for initiating the chain of reactions of the fatty acid synthase in plants and bacteria.


Pssm-ID: 430064 [Multi-domain]  Cd Length: 80  Bit Score: 37.11  E-value: 1.50e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2755059532  84 VENACATGATALHQAIMHVRSGAADIVLAVGAEKLS 119
Cdd:pfam08545   3 INAACSGFVYALSTAAALIRSGRAKNVLVIGAETLS 38
PRK06816 PRK06816
StlD/DarB family beta-ketosynthase;
74-119 2.00e-03

StlD/DarB family beta-ketosynthase;


Pssm-ID: 235866  Cd Length: 378  Bit Score: 39.89  E-value: 2.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2755059532  74 MGFERIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLS 119
Cdd:PRK06816  110 LGAPPIEVVSSAGVCAAGMMALKYAYLSVKAGESRNAVATASELAS 155
FabH COG0332
3-oxoacyl-[acyl-carrier-protein] synthase III [Lipid transport and metabolism]; 3-oxoacyl- ...
 75-119 4.12e-03

3-oxoacyl-[acyl-carrier-protein] synthase III [Lipid transport and metabolism]; 3-oxoacyl-[acyl-carrier-protein] synthase III is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440101 [Multi-domain]  Cd Length: 323  Bit Score: 38.94  E-value: 4.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2755059532  75 GFERIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLS 119
Cdd:COG0332    99 GAKNAAAFDINAACSGFVYALSVAAALIRSGQAKNVLVVGAETLS 143
PRK05790 PRK05790
putative acyltransferase; Provisional
 56-358 7.57e-03

putative acyltransferase; Provisional


Pssm-ID: 180261 [Multi-domain]  Cd Length: 393  Bit Score: 38.21  E-value: 7.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  56 QDVLEGQVVVAGQ------MALRSMGF-ERIPIVNVENACATGATALHQAIMHVRSGAADIVLAVGAEKLSigdktKALG 128
Cdd:PRK05790   49 DEVIMGQVLQAGAgqnparQAALKAGLpVEVPALTINKVCGSGLKAVALAAQAIRAGDADIVVAGGQESMS-----QAPH 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 129 VFDGgvdvnDRQGVRavleeLGGALPEDGKPHSLFMDVY-----AALARAHMNAFGTTRE----------QLALIASKNH 193
Cdd:PRK05790  124 VLPG-----SRWGQK-----MGDVELVDTMIHDGLTDAFngyhmGITAENLAEQYGITREeqdefalasqQKAEAAIKAG 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 194 ----------------EHAVHNPLAHFRAEMSVEEILAARPV---SGPLTVPMCAPLTDGASAVVVCNAAGLKRLdGSRP 254
Cdd:PRK05790  194 rfkdeivpvtikqrkgDPVVVDTDEHPRPDTTAESLAKLRPAfdkDGTVTAGNASGINDGAAAVVVMSEAKAKEL-GLTP 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 255 I-RILA--------AVLQSGTVRplsawdcsvtrlAAQAAYEQAGVGPQDISVAEVHDAssFGellqsellgfceigsgg 325
Cdd:PRK05790  273 LaRIVSyavagvdpAIMGIGPVP------------AIRKALEKAGWSLADLDLIEINEA--FA----------------- 321

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2755059532 326 rfAESGAS--RLGGRMPI-NPSGGLESKGHPMGASG 358
Cdd:PRK05790  322 --AQALAVekELGLDPEKvNVNGGAIALGHPIGASG 355
PKS cd00833
polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different ...
 80-302 7.99e-03

polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits.


Pssm-ID: 238429 [Multi-domain]  Cd Length: 421  Bit Score: 38.31  E-value: 7.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532  80 PIVNVENACATGATALHQAIMHVRSGAADIVLAvgaeklsigdktkalgvfdGGVDVNDRQGVRAVLEElGGALPEDGKP 159
Cdd:cd00833   162 PSLTVDTACSSSLVALHLACQSLRSGECDLALV-------------------GGVNLILSPDMFVGFSK-AGMLSPDGRC 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755059532 160 HSLfmdvyaaLARAHMNAFGttreqlaliasknhehavhnplahfraemsveeilaarpvsgpltvpmcapltDGASAVV 239
Cdd:cd00833   222 RPF-------DADADGYVRG-----------------------------------------------------EGVGVVV 241

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2755059532 240 vcnaagLKRL-----DGSrpiRILA-----AVLQSGTVRPLSAWDCSVTRLAAQAAYEQAGVGPQDISVAEVH 302
Cdd:cd00833   242 ------LKRLsdalrDGD---RIYAvirgsAVNQDGRTKGITAPSGEAQAALIRRAYARAGVDPSDIDYVEAH 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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