NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2755285234|ref|WP_354323607|]
View 

MULTISPECIES: hypothetical protein [unclassified Variovorax]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11472037)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 22-104 6.21e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


:

Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.72  E-value: 6.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755285234  22 LAQAGTEAAAPKDPTIQQIYEAANGGRMSDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSPGLD 101
Cdd:COG5010    43 AAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNP 122


                  ...
gi 2755285234 102 FAR 104
Cdd:COG5010   123 NAY 125
 
Name Accession Description Interval E-value
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 22-104 6.21e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.72  E-value: 6.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755285234  22 LAQAGTEAAAPKDPTIQQIYEAANGGRMSDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSPGLD 101
Cdd:COG5010    43 AAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNP 122


                  ...
gi 2755285234 102 FAR 104
Cdd:COG5010   123 NAY 125
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 20-99 1.41e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.53  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755285234  20 PSLAQAGTEAAAPKDPT-----IQQIYEAANGGRMSDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAK 94
Cdd:TIGR02917 141 LELAQKSYEQALAIDPRslyakLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAI 220


                  ....*
gi 2755285234  95 KLSPG 99
Cdd:TIGR02917 221 ALRPN 225
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 38-99 7.79e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 34.62  E-value: 7.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2755285234  38 QQIYEAANGGRMSDADAMIAKVLK---DHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSPG 99
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALArfpESPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPG 66
 
Name Accession Description Interval E-value
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 22-104 6.21e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.72  E-value: 6.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755285234  22 LAQAGTEAAAPKDPTIQQIYEAANGGRMSDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSPGLD 101
Cdd:COG5010    43 AAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNP 122


                  ...
gi 2755285234 102 FAR 104
Cdd:COG5010   123 NAY 125
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 29-98 2.29e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.64  E-value: 2.29e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2755285234  29 AAAPKDPTIQ----QIYEAAngGRMSDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSP 98
Cdd:COG4783    66 ELDPDEPEARlnlgLALLKA--GDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 20-99 1.41e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.53  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755285234  20 PSLAQAGTEAAAPKDPT-----IQQIYEAANGGRMSDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAK 94
Cdd:TIGR02917 141 LELAQKSYEQALAIDPRslyakLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAI 220


                  ....*
gi 2755285234  95 KLSPG 99
Cdd:TIGR02917 221 ALRPN 225
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 31-115 3.77e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.99  E-value: 3.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755285234  31 APKDPTIQ----QIYEAANGGRmsDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSPGLDFARpe 106
Cdd:COG4235    47 DPDNADALldlaEALLAAGDTE--EAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPAR-- 122


                  ....*....
gi 2755285234 107 AVERLTNKL 115
Cdd:COG4235   123 LLEASIAEA 131
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 20-98 4.46e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.99  E-value: 4.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755285234  20 PSLAQAGTEA--AAPKDPTIQQIYEAANG-GRMSDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKL 96
Cdd:TIGR02917 720 PAAIQAYRKAlkRAPSSQNAIKLHRALLAsGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKK 799


                  ..
gi 2755285234  97 SP 98
Cdd:TIGR02917 800 AP 801
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 22-100 1.00e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.75  E-value: 1.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2755285234  22 LAQAGTEAAAPKDPTIQQIYEAANGGRMSDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSPGL 100
Cdd:COG3914    67 AAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDF 145
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
47-103 1.16e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 1.16e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2755285234  47 GRMSDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSPGLDFA 103
Cdd:COG0457    90 GRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADA 146
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 47-104 1.46e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.36  E-value: 1.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2755285234  47 GRMSDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSPGLDFAR 104
Cdd:COG3914   160 GRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAH 217
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 47-104 2.23e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.86  E-value: 2.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2755285234  47 GRMSDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSPGLDFAR 104
Cdd:COG4783    18 GDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEAR 75
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 29-98 3.24e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 37.29  E-value: 3.24e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2755285234  29 AAAPKDPTIQ----QIYEAAngGRMSDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSP 98
Cdd:COG4235    11 AANPNDAEGWlllgRAYLRL--GRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDP 82
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 29-98 3.57e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 37.63  E-value: 3.57e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2755285234  29 AAAPKDPTIQ----QIYEAAngGRMSDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSP 98
Cdd:COG5010    82 QLDPNNPELYynlaLLYSRS--GDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
47-100 3.61e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.30  E-value: 3.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2755285234  47 GRMSDADAmIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSPGL 100
Cdd:COG3063    40 GRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPSA 92
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 47-100 3.63e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.21  E-value: 3.63e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2755285234  47 GRMSDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSPGL 100
Cdd:COG3914   126 GRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDN 179
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 41-107 4.18e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.51  E-value: 4.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755285234  41 YEAANGGRMSDADAMIAKVLKDHPDS---AKAHFVHAELLAAEGRLQDARGELAKAKKLSPGLDFArPEA 107
Cdd:COG1729     1 KALLKAGDYDEAIAAFKAFLKRYPNSplaPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKA-PDA 69
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 38-99 7.79e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 34.62  E-value: 7.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2755285234  38 QQIYEAANGGRMSDADAMIAKVLK---DHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSPG 99
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALArfpESPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPG 66
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 39-109 8.66e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 37.40  E-value: 8.66e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2755285234  39 QIYEAAngGRMSDADAMIAKVLKDHPDSAKAHFVHAELLAAEGRLQDARGELAKAKKLSPGLDFARPEAVE 109
Cdd:COG2956   152 ELYLEQ--GDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAE 220
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH