NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2758324621|ref|WP_356528847|]
View 

MULTISPECIES: hypothetical protein [unclassified Streptomyces]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-76 2.36e-13

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 2.36e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758324621   7 PAPLGEAAEAVSALALSPDGRTLAVGGDAGSVQPWDVATRQPLgGPLTTPGESIDSLAFAPDGTTLYAGS 76
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL-RTLTGHSGAVTSVAFSPDGKLLASGS 181
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-76 2.36e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 2.36e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758324621   7 PAPLGEAAEAVSALALSPDGRTLAVGGDAGSVQPWDVATRQPLgGPLTTPGESIDSLAFAPDGTTLYAGS 76
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL-RTLTGHSGAVTSVAFSPDGKLLASGS 181
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-76 4.90e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 4.90e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2758324621  15 EAVSALALSPDGRTLAVGGDAGSVQPWDVATRQPLgGPLTTPGESIDSLAFAPDGTTLYAGS 76
Cdd:cd00200   220 NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECV-QTLSGHTNSVTSLAWSPDGKRLASGS 280
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 15-42 3.89e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.05  E-value: 3.89e-03
                           10        20
                   ....*....|....*....|....*...
gi 2758324621   15 EAVSALALSPDGRTLAVGGDAGSVQPWD 42
Cdd:smart00320  13 GPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-76 2.36e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 2.36e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758324621   7 PAPLGEAAEAVSALALSPDGRTLAVGGDAGSVQPWDVATRQPLgGPLTTPGESIDSLAFAPDGTTLYAGS 76
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL-RTLTGHSGAVTSVAFSPDGKLLASGS 181
WD40 COG2319
WD40 repeat [General function prediction only];
8-76 2.61e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 2.61e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2758324621   8 APLGEAAEAVSALALSPDGRTLAVGGDAGSVQPWDVATRQPLGGpLTTPGESIDSLAFAPDGTTLYAGS 76
Cdd:COG2319   282 RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTGAVRSVAFSPDGKTLASGS 349
WD40 COG2319
WD40 repeat [General function prediction only];
16-76 3.88e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.55  E-value: 3.88e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2758324621  16 AVSALALSPDGRTLAVGGDAGSVQPWDVATRQPLgGPLTTPGESIDSLAFAPDGTTLYAGS 76
Cdd:COG2319   206 AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL-RTLTGHSGSVRSVAFSPDGRLLASGS 265
WD40 COG2319
WD40 repeat [General function prediction only];
8-76 8.97e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 8.97e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2758324621   8 APLGEAAEAVSALALSPDGRTLAVGGDAGSVQPWDVATRQPLgGPLTTPGESIDSLAFAPDGTTLYAGS 76
Cdd:COG2319   240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL-RTLTGHSGGVNSVAFSPDGKLLASGS 307
WD40 COG2319
WD40 repeat [General function prediction only];
8-76 1.02e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 1.02e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2758324621   8 APLGEAAEAVSALALSPDGRTLAVGGDAGSVQPWDVATRQPLgGPLTTPGESIDSLAFAPDGTTLYAGS 76
Cdd:COG2319   156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTGHTGAVRSVAFSPDGKLLASGS 223
WD40 COG2319
WD40 repeat [General function prediction only];
16-76 9.07e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 9.07e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2758324621  16 AVSALALSPDGRTLAVGGDAGSVQPWDVATRQPLgGPLTTPGESIDSLAFAPDGTTLYAGS 76
Cdd:COG2319   332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL-RTLTGHTGAVTSVAFSPDGRTLASGS 391
WD40 COG2319
WD40 repeat [General function prediction only];
7-76 2.23e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 2.23e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758324621   7 PAPLGEAAEAVSALALSPDGRTLAVGGDAGSVQPWDVATRQPLgGPLTTPGESIDSLAFAPDGTTLYAGS 76
Cdd:COG2319    71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLL-RTLTGHTGAVRSVAFSPDGKTLASGS 139
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-76 4.90e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 4.90e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2758324621  15 EAVSALALSPDGRTLAVGGDAGSVQPWDVATRQPLgGPLTTPGESIDSLAFAPDGTTLYAGS 76
Cdd:cd00200   220 NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECV-QTLSGHTNSVTSLAWSPDGKRLASGS 280
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-76 2.11e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 2.11e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758324621  17 VSALALSPDGRTLAVGGDAGSVQPWDVATRQPLgGPLTTPGESIDSLAFAPDGTTLYAGS 76
Cdd:cd00200   180 VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGS 238
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-76 5.45e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.86  E-value: 5.45e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758324621  17 VSALALSPDGRTLAVGGDAGSVQPWDVATRQPLGGpLTTPGESIDSLAFAPDGTTLYAGS 76
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-LKGHTGPVRDVAASADGTYLASGS 70
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-76 1.11e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 1.11e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2758324621  15 EAVSALALSPDGRTLAVGGDAGSVQPWDVATRQPLgGPLTTPGESIDSLAFAPDGTTLYAGS 76
Cdd:cd00200    94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL-TTLRGHTDWVNSVAFSPDGTFVASSS 154
WD40 COG2319
WD40 repeat [General function prediction only];
8-45 2.00e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.51  E-value: 2.00e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2758324621   8 APLGEAAEAVSALALSPDGRTLAVGGDAGSVQPWDVAT 45
Cdd:COG2319   366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-76 1.04e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 37.31  E-value: 1.04e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2758324621  16 AVSALALSPDGRTLAVGGDAGSVQPWDVATrqplGGPLTT-PG--ESIDSLAFAPDGTTLYAGS 76
Cdd:cd00200   137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRT----GKCVATlTGhtGEVNSVAFSPDGEKLLSSS 196
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-76 2.40e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 36.16  E-value: 2.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2758324621  10 LGEAAEAVSALALSPDGRTLAVGGDAGSVQPWDVATRQPLgGPLTTPGESIDSLAFAPDGTTLYAGS 76
Cdd:cd00200    47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV-RTLTGHTSYVSSVAFSPDGRILSSSS 112
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 15-42 3.89e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.05  E-value: 3.89e-03
                           10        20
                   ....*....|....*....|....*...
gi 2758324621   15 EAVSALALSPDGRTLAVGGDAGSVQPWD 42
Cdd:smart00320  13 GPVTSVAFSPDGKYLASGSDDGTIKLWD 40
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 7-95 4.09e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 35.03  E-value: 4.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758324621   7 PAPLGEAAEAVSALALSPDGRTLAVGGDAGSVqpWDVATRQPLGGPLTTPGESIDSLAFAPDGTTL-YAGSPHVPLQRYV 85
Cdd:COG0823    67 PRRLTFGGGYNASPSWSPDGKRLAFVSRSDGR--FDIYVLDLDGGAPRRLTDGPGSPSWSPDGRRIvFSSDRGGRPDLYV 144

                          90
                  ....*....|
gi 2758324621  86 VDPERAVTEV 95
Cdd:COG0823   145 VDLDGRKRRL 154
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
20-76 6.00e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 35.06  E-value: 6.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2758324621  20 LALSPDGRTLAV-GGDAGSVQPWDVATRQPLGgplTTP-GESIDSLAFAPDGTTLYAGS 76
Cdd:COG3391   115 LAVDPDGGRLYVaDSGNGRVSVIDTATGKVVA---TIPvGAGPHGIAVDPDGKRLYVAN 170
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 13-74 8.26e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 35.01  E-value: 8.26e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2758324621   13 AAEAVSALALSPDGRTLAVG--GDAGSVQPWDVATRQplggpLT-TPGESIDSLAFAPDGTTLYA 74
Cdd:COG4946    300 VSGYLTSFALSPDGKRVAFEarGEVFTVPAEKGPTRN-----LTnTPGVRERLPAWSPDGKSIAY 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH