|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
29-471 |
2.54e-82 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 259.41 E-value: 2.54e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 29 LVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAA 108
Cdd:cd17321 2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 109 QSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNL 188
Cdd:cd17321 82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELF----GWRWIFLINV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 189 PIGVLCLVLAhrllpdtpgargvrlreldplgvlllgagvvalllpfvqsrqwpgdekylllvvaaallaafawwerrct 268
Cdd:cd17321 158 PIGLVALLLA---------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 269 rsgaeplldlalyrvRSYSLGSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLG 348
Cdd:cd17321 168 ---------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFG 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 349 -RPLVVAGLLMVAIGLAGTAFAVHQVTgkgiGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVG 427
Cdd:cd17321 233 pRLVLVAGLLLTAVGLLLLALLGADSS----VWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLG 308
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 2764013522 428 SAIGIAAVGSVFFGRLAD---------------DGWSNAYDHGLIVSVGFVIAALLVAV 471
Cdd:cd17321 309 GALGVALLGALLTAGLSAnlgdsgvaallsaaaAAFAAGFHLAFLVAAALALLAALLAL 367
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
28-470 |
2.09e-71 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 231.31 E-value: 2.09e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 28 CLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGA 107
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 108 AQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVN 187
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNL----SWRWIFYIN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 188 LPIGVLCLVLAhrllpdtpgargvrlreldplgvlllgagvvalllpfvqsrqwpgdekylllvvaaallaafawwerrc 267
Cdd:cd17503 157 LPIGILALLLA--------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 268 trsgaePLLDLALYRVRSYSLGSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRL 347
Cdd:cd17503 168 ------PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKF 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 348 G-RPLVVAGLLMVAIGLAGTAFAVHQVTgkgiGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRV 426
Cdd:cd17503 242 GpRLLLLAGLLLLALGTLLLAFLTPDTS----LWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQL 317
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 2764013522 427 GSAIGIAAVGSV---------------FFGRLADDGWSNAYDHGLIVSVGFVIAALLVA 470
Cdd:cd17503 318 GGSIGTALLATLltnrtqfhhsrlselLAQQVQKQALIIAFNDAFLVSAILLLVGLLLA 376
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
24-433 |
5.62e-64 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 214.94 E-value: 5.62e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 24 ALAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASA 103
Cdd:TIGR00711 3 LTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 104 ACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWV 183
Cdd:TIGR00711 83 LCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENY----HWRWI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 184 FYVNLPIGVLCLVLAHRLLP-DTPGARgvrlRELDPLGVLLLGAGVVALLLPFVQSRQ--WPGDEKYLLLVVAAALLAAF 260
Cdd:TIGR00711 159 FLINVPIGIIVVVVAFFILPrDKPAAS----ENFDFLGLLLLSVGLGSLLYGLSEGPErgWFDSNEILILSITGLVAIIA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 261 --AWWERRctrsgAEPLLDLALYRVRSYSLGSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAG 338
Cdd:TIGR00711 235 fvVWELTD-----DNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSP 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 339 IGGRLVDRLG-RPLVVAGLLMVAIGLAGTAFavhQVTGKGIGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAG 417
Cdd:TIGR00711 310 IAGRMGDKIDpRKLVTIGLILYAVGFYWRAF---TFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGS 386
|
410
....*....|....*.
gi 2764013522 418 GALQTGQRVGSAIGIA 433
Cdd:TIGR00711 387 SLSNFTRQLGGSIGTA 402
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
16-430 |
1.66e-52 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 180.94 E-value: 1.66e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 16 TPDPNRWKALAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGL 95
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 96 VLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAg 175
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 176 adeGWRWVFYVNLPIGVLCLVLAHRLLPDTPGARGVRLREldplgvlllgagvvalllpfvqsrqwpgdekylllvvaaa 255
Cdd:COG2814 162 ---GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRG---------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 256 llaafawwerrctrsgaeplLDLALYRVRSYSLGSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGL 335
Cdd:COG2814 199 --------------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVL 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 336 SAGIGGRLVDRLGR-PLVVAGLLMVAIGLAGTAFAVHqvtgkgiGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAG 414
Cdd:COG2814 259 GALLAGRLADRFGRrRLLLIGLLLLALGLLLLALAGS-------LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARG 331
|
410
....*....|....*.
gi 2764013522 415 SAGGALQTGQRVGSAI 430
Cdd:COG2814 332 RASGLYNSAFFLGGPL 347
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
29-433 |
3.90e-46 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 163.50 E-value: 3.90e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 29 LVAGFMTLLDVSIVNVALPSIRTGLDTpESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAA 108
Cdd:cd17502 2 MLALFLAALDQTIVATALPTIVAEFGG-LSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 109 QSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNL 188
Cdd:cd17502 81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHL----SWRWCFYINL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 189 PIGVLCLVLahrllpdtpgargvrlreldplgvlllgagvvalllpfvqsrqwpgdekylllvvaaallaafawwerrct 268
Cdd:cd17502 157 PIGGLALAL----------------------------------------------------------------------- 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 269 rsgaeplldlalyrVRSYSLGSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLG 348
Cdd:cd17502 166 --------------LRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTG 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 349 R--PLVVAGLLMVAIGlagtAFAVHQVTGKGIGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRV 426
Cdd:cd17502 232 RykPLIVIGTILMSVG----AGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSL 307
|
....*..
gi 2764013522 427 GSAIGIA 433
Cdd:cd17502 308 GGTLGVA 314
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
14-308 |
9.80e-42 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 150.73 E-value: 9.80e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 14 AYTPDPNRWKALAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMA 93
Cdd:COG0477 5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 94 GLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQA 173
Cdd:COG0477 85 GLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 174 AgadeGWRWVFYVNLPIGVLCLVLAHRLLPDTPGARGVRLRELDPLGVLLLGAGVVALLLPFVQSRQWPGDEKYLLLVVA 253
Cdd:COG0477 165 L----GWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 2764013522 254 AALLAAFAWWERRCTRSGAEPLLDLALYRVRSYSLGSALGLLYFAGFTSIFFVST 308
Cdd:COG0477 241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
17-436 |
1.12e-37 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 143.72 E-value: 1.12e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 17 PDPNRWKaLAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLV 96
Cdd:PRK10504 5 PDSVRWQ-LWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 97 LFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPqITALIQQMFRGRERGKAFGAFGSVVG-ISTAVGPLLGGLLIQAAg 175
Cdd:PRK10504 84 LFTLGSLFCALSGTLNELLLARVLQGVGGAMMVP-VGRLTVMKIVPREQYMAAMTFVTLPGqVGPLLGPALGGLLVEYA- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 176 adeGWRWVFYVNLPIGVLCLVLAHRLLPDTPgargVRLRELDPLGVLLLGAGVVALLLPFVQSRQWPGDE-KYLLLVVAA 254
Cdd:PRK10504 162 ---SWHWIFLINIPVGIIGAIATLMLMPNYT----MQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPlAIAGLVAVG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 255 ALLAAFAWWErrcTRSGAEPLLDLALYRVRSYSLGSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSG 334
Cdd:PRK10504 235 VVALLLYLLH---ARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSM 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 335 LSAGIGGRLVDRLG--RPLVVAGLLMVAIGLAGTAFAVhqvtgkgIGWALIAP--LLFAGLGSGLVISPNQTLTLSEVPV 410
Cdd:PRK10504 312 GMKRIVVQVVNRFGyrRVLVATTLGLALVSLLFMLVAL-------LGWYYLLPfvLFLQGMVNSTRFSSMNTLTLKDLPD 384
|
410 420
....*....|....*....|....*.
gi 2764013522 411 RRAGSAGGALQTGQRVGSAIGIAAVG 436
Cdd:PRK10504 385 NLASSGNSLLSMIMQLSMSIGVTIAG 410
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-471 |
1.43e-36 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 138.86 E-value: 1.43e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 28 CLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGA 107
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 108 AQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVN 187
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL----GYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 188 LPIGVLCLVLAHRLLPDTPGARGVRLRELDPLGVLLlgagvvalllpfvqsrqwpgdekylllvvaaallaafawwerrc 267
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPNKRAVSAARLRSGL-------------------------------------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 268 trsgaeplldLALYRVRSYSLGSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRL 347
Cdd:cd17325 193 ----------RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 348 GR-PLVVAGLLMVAIGLAGTAFAvhqvtgkGIGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRV 426
Cdd:cd17325 263 GRkPLILIGLLLSAVALLLLPLA-------TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL 335
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 2764013522 427 GSAIgiaavGSVFFGRLADD-GWSNAYdhglIVSVGFVIAALLVAV 471
Cdd:cd17325 336 GMVL-----GPLLGGFLYDAfGFATPF----LAAAALLLLAAVLFL 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-471 |
7.51e-36 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 136.54 E-value: 7.51e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 16 TPDPNRWKALAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGL 95
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 96 VLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAg 175
Cdd:COG2271 83 LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 176 adeGWRWVFYVnlpIGVLCLVLAhrllpdtpgargvrlreldPLGVLLLGAGVValllpfvqsrqwpgdekylllvvaaa 255
Cdd:COG2271 162 ---GWRAAFLI---LGLPGLLLA-------------------LLRFWLLALAYF-------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 256 llaafawwerrctrsgaeplldlalyrvrsyslgsalglLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGL 335
Cdd:COG2271 191 ---------------------------------------LVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIV 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 336 SAGIGGRLVDRLGR---PLVVAGLLMVAIGLAGTAFAvhqvtgkGIGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRR 412
Cdd:COG2271 232 GSLLGGWLSDRLGRrrkLVLAIGLLLAALALLLLALL-------PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKA 304
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 2764013522 413 AGSAGGALQTGQRVGSAIGIAAVGSVffgrLADDGWSNAYdhgLIVSVGFVIAALLVAV 471
Cdd:COG2271 305 RGTASGLVNTFGFLGGALGPLLVGYL----LDATGYQAAF---LLLAALALLAALLALL 356
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
29-431 |
1.14e-34 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 132.93 E-value: 1.14e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 29 LVAGFMTLLDVSIVNVALPS-IRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGA 107
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 108 AQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVN 187
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF----GWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 188 LPIGVLCLVLAHRLLPDTPGARGVRLRELDPLGVLLLGAGVVALLLPFVqsrqwpgdekylllvvaaallaafawwerrc 267
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLL------------------------------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 268 trsgaeplldlalyrvrsyslgsaLGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRL 347
Cdd:pfam07690 207 ------------------------LALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 348 G-RPLVVAGLLMVAIGLAGTAFAVHQVTgkgiGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRV 426
Cdd:pfam07690 263 GrRRRLLLALLLLILAALGLLLLSLTLS----SLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
|
....*
gi 2764013522 427 GSAIG 431
Cdd:pfam07690 339 GGALG 343
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
39-441 |
1.02e-33 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 130.77 E-value: 1.02e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 39 VSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISR 118
Cdd:cd17320 15 IDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIAR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 119 LVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNLPIGVLCLVLA 198
Cdd:cd17320 95 FLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFF----GWRAIFVFLALLGLLLLLLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 199 HRLLPDTPGARGVRLRELDPLGVLLLgagvvalllpfvqsrqwpgdekylllvvaaallaafawwerrctrsgaeplldl 278
Cdd:cd17320 171 LLFLPETLPEEKRKPLLSSLLRAYKR------------------------------------------------------ 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 279 aLYRVRSYSLGSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLGrPLVVAGLLM 358
Cdd:cd17320 197 -VLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFG-PRRLLRLGL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 359 VAIGLAGTAFAVHQVTGKGIGWALIAPLLFAGLGSGLVISPNQTLTLSEVPvRRAGSAGGALQTGQRVGSAIGIAAVGSV 438
Cdd:cd17320 275 LLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGALVGLL 353
|
...
gi 2764013522 439 FFG 441
Cdd:cd17320 354 PNG 356
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
29-470 |
2.02e-33 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 130.00 E-value: 2.02e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 29 LVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAA 108
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 109 QSSLWLVISRLVQGVAGGLVsPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNL 188
Cdd:cd17504 82 PNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHL----GWRWIFWTAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 189 PIGVLCLVLAhrllpdtpgargvrlreldplgvlllgagvvalllpfvqsrqwpgdekylllvvaaallaafawwerrct 268
Cdd:cd17504 157 PVAVLLAALV---------------------------------------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 269 rsgaePLLDLALYRVRSYSLGSALGLLYFAGFTSIFFVSTLYLQS----GLHYTALQAGLTLTPFALGSGLSAGIGGRLV 344
Cdd:cd17504 167 -----PLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLI 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 345 DRLG-RPLVVAGLLMVAIGLAGTAFAVHQVtgkgigWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTG 423
Cdd:cd17504 242 ARVGpRRVLLIGLVISAVGLLLLALLHSSL------WALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVL 315
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 2764013522 424 QRVGSAIGIAAVGSV--------FFGRLADDGwsnAYDHGLIVSVGFVIAALLVA 470
Cdd:cd17504 316 RTIGSAIGPAIAGAIlttytvsiTSGGVPTEG---AYVLAFLIGAALALAALLLS 367
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
26-476 |
2.23e-33 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 130.00 E-value: 2.23e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 26 AVCLVAgFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAAC 105
Cdd:cd17474 3 AVFFAT-LLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 106 GAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLiqaagADEGWRWVFY 185
Cdd:cd17474 82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-----AAISWRYPFF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 186 VnLPIGVLCLVLAHRLLPDTPGARGVRLRELDPLGVlllgagvvalllpfvqsrqwpgdekylllvvaaallaafawwer 265
Cdd:cd17474 157 L-LAALIPVAFLAILFLLPEPKEKAKSSSATKLRDL-------------------------------------------- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 266 rctrsgaeplldLALYRVRSYSLGSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVD 345
Cdd:cd17474 192 ------------KKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLK 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 346 R--LGRPLVVAGLLMVAIGLAGTAFAVHQvtgkgigWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTG 423
Cdd:cd17474 260 KrfGARRILVIGLLLYALSLLLLGFVPSL-------ALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFV 332
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 2764013522 424 QRVGsaigiAAVGSVFFGRLaddgwsnaYDHGLIVSVGFVIAALLVAVADVVA 476
Cdd:cd17474 333 RFLG-----QAVGPLLFGLL--------LEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
26-438 |
2.74e-32 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 126.61 E-value: 2.74e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 26 AVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAAC 105
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 106 GAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFR-GRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVF 184
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPpGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLA----WWPWIF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 185 YVNLPIGVLCLVLAhrllpdtpgargvrlreldplgvlllgagvvalllpfvqsrqwpgdekylllvvaaallaafAWWE 264
Cdd:cd17476 157 WFLAILAAIVAVAA--------------------------------------------------------------IFWT 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 265 RRCTRSgaeplldlalyrvrsySLGSAlgLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLV 344
Cdd:cd17476 175 SPSFIA----------------VLLAV--FLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLI 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 345 DRLGRPLVVAgLLMVAIGLAGTAFAVHQVtgKGIGWALIAP-LLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTG 423
Cdd:cd17476 237 ARLPPSYIMA-ISMVAFLVGPILFATMPV--HQTYWAQAFPaMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTV 313
|
410
....*....|....*
gi 2764013522 424 QRVGSAIGIAAVGSV 438
Cdd:cd17476 314 VNYGISIGLGIAGTV 328
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
21-436 |
1.72e-29 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 120.99 E-value: 1.72e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 21 RWKALAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTL 100
Cdd:PRK14995 4 QWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 101 ASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMF-RGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeG 179
Cdd:PRK14995 84 ASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHF----Y 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 180 WRWVFYVNLPIGVLCLVLAHRLLPDTPGARGVRLReLDPLGVLLlgagVVALLLPFVQSRQWPGDEKYLLLVVAAALLAA 259
Cdd:PRK14995 160 WGSVFLINVPIVLVVMGLTARYVPRQAGRRDQPLN-LGHALMLI----VAILLLVYSAKTALKGFLSLWVTSLTLLTGAL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 260 FAWWERRCTRSGAEPLLDLALYRVRSYSLGSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGI 339
Cdd:PRK14995 235 LLGLFIRTQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPI 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 340 GGRLVDRLG-RPLVVAGLLMVAI---GLAGTAFAVHQVtgkgIGWALIAPLLFAgLGSGLVISpnQTLTLSEVPVRRAGS 415
Cdd:PRK14995 315 AGILVSRLGlRLVATGGMALSALsfyGLAMTDFSTQQW----QAWGLMALLGFS-AASALLAS--TSAIMAAAPPEKAAA 387
|
410 420
....*....|....*....|.
gi 2764013522 416 AGGALQTGQRVGSAIGIAAVG 436
Cdd:PRK14995 388 AGAIETMAYELGAGLGIAIFG 408
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-472 |
3.70e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 118.44 E-value: 3.70e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 19 PNRWKALAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLF 98
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 99 TLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgade 178
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 179 GWRWVFYVNLPIGVLCLVLAHRLLPDTPGARGVRLReldplgvlllgAGVVALLLPFVQSRQWpgdekylllvvaaalla 258
Cdd:COG2223 157 GWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK-----------ASLRDQLEALRDPRFW----------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 259 afawwerrctrsgaeplldlalyrvrsyslgsALGLLYFAGFTSIFFVST---LYLQSGLHYTALQAGLTLTPFALGSGL 335
Cdd:COG2223 209 --------------------------------LLSLLYFGTFGSFIGFSSwlpPYLVDQFGLSAATAGLLAALFALLGAL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 336 SAGIGGRLVDRLGRPLV-VAGLLMVAIGLAGTAFAVHQVtgkgigWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAG 414
Cdd:COG2223 257 GRPLGGWLSDRIGGRRVlLIVFALMALGLLLLALALGSL------WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAG 330
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 2764013522 415 SAGGALQTGQRVGSAIGIAAVGSVFfgrladdGWSNAYDHGLIVSVGFVIAALLVAVA 472
Cdd:COG2223 331 AVYGLVGAAGGLGGFLGPLLFGALL-------DATGSYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
25-423 |
1.24e-27 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 113.82 E-value: 1.24e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 25 LAVCLVAGFMTLLDVSIVNVALPSI-RTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASA 103
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIaQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 104 ACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLiqaagADEGWRWV 183
Cdd:cd17473 81 AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL-----AEIGWRAP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 184 FYVNLpIGVLCLVLAHRLLPDTPGARGVRLRELDplgvlllgagvvalllpfvqsrqwpgdekylllvvaaallaafaww 263
Cdd:cd17473 156 FLVYL-LALPVLILVLLFLPEPARKSKSAASPGA---------------------------------------------- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 264 errcTRSGAEPLLDLALYrvrsYSLGSALGLLYFAGFTSIFFvstlYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRL 343
Cdd:cd17473 189 ----ATAAALPWKRVLPI----YFLAFLAMLLFYVIPIQLPF----LLQERGGGSAALIGLALAIASLAGAIGALLFGRL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 344 VDRLGRPLVVA-GLLMVAIGLAGTAFAVHQvtgkgigWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQT 422
Cdd:cd17473 257 KRRLGKRRLLAiGFALMALGFLLLALASGL-------WVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTS 329
|
.
gi 2764013522 423 G 423
Cdd:cd17473 330 A 330
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
25-445 |
2.03e-27 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 115.03 E-value: 2.03e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 25 LAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESdlQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAA 104
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNS--TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 105 CGAAQSSLWLVISRLVQGVAGGLVSPqITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAagADEGWRWVF 184
Cdd:cd06179 79 AGTAKSVNMLIGGQALIGIGAGTQGL-GAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEA--NAAGWRWIF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 185 YVNLPIGVLCLVL-------AHRLLPDTPGARGVrLRELDPLGVLLLGAGVVALLLPFVQSRQ---WPGDEKYLLLVVAA 254
Cdd:cd06179 156 YINAIFNALALILlfffyhpPPRPQLHGSSTRQK-LKRLDWVGLFLLIAGLVLFLLGLSWGGNpypWSSAHVIAPLVIGG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 255 ALLAAFAWWERRCTRSGaePLLDLALYRVRSYSL----GSALGLLYFAgfTSIFFvsTLYLQSGLHYTALQAGLTLTPFA 330
Cdd:cd06179 235 VLLIAFGLYEWKGTKDG--LLPPRLLFRGRNFALilivAFVEGMIFYS--LNIFW--PQQISLLFTTDPLKAGLYQLPFG 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 331 LGSGLSAGIGGRLVDRLGR---PLVVAGLLMVA--IGLA-------GTAFAVHQVTGKGIGWALIAPLLFAGLGsglvis 398
Cdd:cd06179 309 LGTLFGAILAGLLLTKIKHikwQLVAGFVLFTAflALLAlitpdnkALAIAFSVLAGIGIGGPLVLAIVIVQLS------ 382
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 2764013522 399 pnqtltlseVPVRRAGSAGGALQTGQRVGSAIGIAAVGSVFFGRLAD 445
Cdd:cd06179 383 ---------VPPEDIGTASGLLGSARALGGAVGTAIFTSILSNRLSK 420
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
30-470 |
3.35e-26 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 109.56 E-value: 3.35e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 30 VAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQ 109
Cdd:cd17324 6 LAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 110 SSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNLP 189
Cdd:cd17324 86 SFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL----GWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 190 IGVLCLVLAHRLLPDTPGARGVRLRELDPLGVLLlgagvvalllpfvqsrqwpgdekylllvvaaallaafawwerrctr 269
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLL---------------------------------------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 270 sgaeplldlalyRVRSYSLGSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLG- 348
Cdd:cd17324 196 ------------RNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGr 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 349 RPLVVAGLLMVAIGLAGTAFAvhqvtgkGIGWALIAPLLFAGLGSGLVISPNQTLtLSEVPVRRAGSAGGALQTGQRVGS 428
Cdd:cd17324 264 RALLIALLLLAAALLLLTLLG-------PSPLLLLVGLVLWGLGFFAAHSALQTR-VLRLAPEARGLASSLYLAAYNLGG 335
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 2764013522 429 AIGiAAVGSVFFGRLaddGWSNAydhgLIVSVGFVIAALLVA 470
Cdd:cd17324 336 ALG-AALGGLVLDHG---GWAGV----GWVGAALLLLALLLA 369
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
29-471 |
1.00e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 108.28 E-value: 1.00e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 29 LVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAA 108
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 109 QSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGAdeGWRWVFYVNL 188
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF--GWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 189 PIGVLCLVLAHRLLPDTPGARGVRLRELDPLGVLLLGagvvalllpfvqsrqwpgdekylllvvaaallaafawwerrct 268
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 269 rsgaeplldLALYRVRSYSLGSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLG 348
Cdd:cd06174 197 ---------KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 349 --RPLVVAGLLMVAIGLAGTAFAVHQvtgkgigWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRV 426
Cdd:cd06174 268 grKPLLLIGLLLMALGLALLLLAPSL-------LLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFL 340
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 2764013522 427 GSAIGIAAVGSVFfgrladdGWSNAYDHGLIVSVGFVIAALLVAV 471
Cdd:cd06174 341 GGAIGPLLAGFLL-------AATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
19-472 |
5.97e-21 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 94.54 E-value: 5.97e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 19 PNRWKALAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLF 98
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 99 TLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRgRERGKAFGAFGSVVGISTAVGPLLGGLLIqAAGADE 178
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLI-LLGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 179 GWRWVFYVnlpigvlclvlahrllpdtpgargvrlreldpLGVLLLGAGVVALLLPFVQsrqwpgdekylllvvaaalla 258
Cdd:COG0738 162 SWHLPYLI--------------------------------LAVLLLLLALLFLRSKLPE--------------------- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 259 afawWERRCTRSGAEPLLDLALYRVRSYSLGSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAG 338
Cdd:COG0738 189 ----IEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRF 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 339 IGGRLVDRLG-RPLVVAGLLMVAIGLAGTAFAVHqvtgkgiGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAG 417
Cdd:COG0738 265 LGGFLLKRFGpVRLLRLSALLAAVGLLLALLAPG-------PWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVS 337
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 2764013522 418 GALqtgqrvGSAIGIAAVGSVFFGRLADdgwSNAYDHGLIVSVGFVIAALLVAVA 472
Cdd:COG0738 338 AVL------IMGIVGGAIGPPLIGFLAD---AFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
21-472 |
7.53e-21 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 93.79 E-value: 7.53e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 21 RWKALAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTL 100
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 101 ASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGW 180
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF----GW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 181 RWVFYVnlpIGVLCLVLAhrllpdtpgargvrlreldpLGVLLLGAGVVALLLPFVqsrqwpgdekylllvvaaalLAAF 260
Cdd:cd17319 157 RWAFII---EGLLGLLLA--------------------VLWWFYLRQVWGLALGYF--------------------GINY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 261 AWWerrctrsgaeplldlalyrvrsyslgsalGLLYFagftsiffvSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIG 340
Cdd:cd17319 194 ALY-----------------------------GLLTW---------LPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILG 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 341 GRLVDRLG----RPLVVAGLLMVAIGLAGTAFAVHQvtgkgigWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSA 416
Cdd:cd17319 236 GRLSDRLLrgarRLVIIIGLLLAAVGLLLAYLTTSP-------VVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATA 308
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 2764013522 417 GGALQTGQRVGSAIgiaavGSVFFGRLADdgWSNAYDHGLIVSVGFVIAALLVAVA 472
Cdd:cd17319 309 GGLINSGGNLGGFV-----APLLIGYLVD--ATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
45-205 |
8.06e-19 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 88.21 E-value: 8.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 45 ALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVA 124
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 125 GGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNLPIGVLCLVLAHRLLPD 204
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWL----SWHAIFAFLSLAGILLSALIFFILPE 182
|
.
gi 2764013522 205 T 205
Cdd:TIGR00710 183 T 183
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
62-205 |
3.13e-18 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 81.16 E-value: 3.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 62 WVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFR 141
Cdd:TIGR00880 2 LLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2764013522 142 GRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNLPIGVLCLVLAHRLLPDT 205
Cdd:TIGR00880 82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQFL----GWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
22-438 |
6.14e-18 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 85.49 E-value: 6.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 22 WKALAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSG--YALAFGLFLvpSGRLGDARGRRRVFMAGLVLFT 99
Cdd:TIGR00895 16 WRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAglIGMAFGALF--FGPLADRIGRRRVLLWSILLFS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 100 LASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIqaagADEG 179
Cdd:TIGR00895 94 VFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLI----PVFG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 180 WRWVFYVNLPIGVLCLVLAHRLLPDTpgargvrlreldplgvlllgagvvallLPFVQSRQWPGDEKYLLLVVAAALLAA 259
Cdd:TIGR00895 170 WRSLFYVGGIAPLLLLLLLMRFLPES---------------------------IDFLVSKRPETVRRIVNAIAPQMQAEA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 260 FAWWERRCTRSGAEPLLDLALYRVRSYSLGSALGLLYFAGFTSIFFVSTL--YLQSGLHYTALQAGLTLTPFALGSGLSA 337
Cdd:TIGR00895 223 QSALPEQKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWlpKLMVELGFSLSLAATGGALFNFGGVIGS 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 338 GIGGRLVDRLGRPLVVAGLLMVAIGLAGTAFAVHQVTGkgigwALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAG 417
Cdd:TIGR00895 303 IIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTL-----LLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVG 377
|
410 420
....*....|....*....|.
gi 2764013522 418 GALQTGqRVGSAIGIAAVGSV 438
Cdd:TIGR00895 378 WAIGIG-RLGAIIGPILAGYL 397
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
21-202 |
2.26e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.78 E-value: 2.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 21 RWKALAVCLVAGFMTLLDVSIVNVALPS-IRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFT 99
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 100 LASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGadeg 179
Cdd:cd17325 277 VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG---- 352
|
170 180
....*....|....*....|...
gi 2764013522 180 WRWVFYVNLPIGVLCLVLAHRLL 202
Cdd:cd17325 353 FATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
25-203 |
4.72e-17 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 82.62 E-value: 4.72e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 25 LAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAA 104
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 105 CGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVF 184
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSL----GWRWIF 156
|
170
....*....|....*....
gi 2764013522 185 YVNLPIGVLCLVLAHRLLP 203
Cdd:cd17323 157 WFLAIISGFCLILIFLFLP 175
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
78-474 |
6.29e-17 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 82.26 E-value: 6.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 78 SGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVG 157
Cdd:cd17489 51 AGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATT 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 158 ISTAVGPLLGGLLIQAAGAdegwRWVFYVNLPIGVLCLVLAHRLLPDTPGARGVRLRELDPLGVLLLGAGVVALLLPFVQ 237
Cdd:cd17489 131 LAMALGPALGLFLYQHLGF----AVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLA 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 238 SrqwpgdekylllvvaaallaafawwerrctrsgaeplldlalyrvrsyslgsalgllyfAGFTSIFFVSTLYLQSGLHY 317
Cdd:cd17489 207 S-----------------------------------------------------------IAYGAISTFLPLYAAERGIS 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 318 talQAGLTLTPFALGSGLSAGIGGRLVDRLGR-PLVVAGLLMVAIGLAGTAFAvhqvtgkGIGWALIAPLLFAGLGSGLV 396
Cdd:cd17489 228 ---NAGLFFTVYAIALLLSRPFSGKLSDRKGPkTVIIPGLLLLALGLLLLSFA-------GSPWMLLLAAVLYGLGFGLL 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2764013522 397 ISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIgiaavGSVFFGRLADdgwSNAYDHGLIVSVGFVIAALLVAVADV 474
Cdd:cd17489 298 FPALQALAVDLVPPHRRGAANGTFFIFFDLGIGL-----GGLLLGLVAE---LFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
25-202 |
2.23e-16 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 80.34 E-value: 2.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 25 LAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFL--VPSGRLGDARGRRRVFMAGLVLFTLAS 102
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIgaLLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 103 AACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGADEGWRW 182
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRI 160
|
170 180
....*....|....*....|
gi 2764013522 183 VFYVNLPIGVLCLVLAHRLL 202
Cdd:cd17316 161 LFLIGALPALLALLLRRRTL 180
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
25-206 |
5.41e-16 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 79.59 E-value: 5.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 25 LAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAA 104
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 105 CGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGadeGWRWVF 184
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG---GWRWAF 157
|
170 180
....*....|....*....|..
gi 2764013522 185 YVNLPIGVLCLVLAHRLLPDTP 206
Cdd:cd17328 158 RVTGVLGVLLAILLLLFVREPP 179
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
7-471 |
7.30e-16 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 79.15 E-value: 7.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 7 ASPAPEEAYTPDPNRWKALAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARG 86
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 87 RRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGReRGKAFGAFGSVVGISTAVGPLL 166
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 167 GGLLIQAAgadeGWRWVFYVNLPIGVLCLVLAHRLLPDTPGARGvrlreldplgvlllGAGVVALLLPFVQSRQwpgdek 246
Cdd:COG2807 161 TVPLAAAL----GWRGALAVWALLALLALLLWLPLLRRRPAAAA--------------AAPAAASLRSLWRSPL------ 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 247 ylllvvaaallaafAWWerrctrsgaeplldlalyrvrsysLGSALGLLYFAGFTSIFFVSTLYLQSGlhYTALQAGLTL 326
Cdd:COG2807 217 --------------AWL------------------------LTLFFGLQSLLYYAVVAWLPPILRDAG--LSAATAGLLL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 327 TPFALGSGLSAGIGGRLVDRLG--RPLVVAGLLMVAIGLAGTAFAvhqvtgkgIGWALIAPLLFAGLGSGLVISpnqtLT 404
Cdd:COG2807 257 SLFQLAGIPGSLLVPLLADRLGdrRPLLLLLGLLGLAGLLGLLLA--------PGSLPWLWAVLLGLGQGGLFP----LA 324
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2764013522 405 LSeVPVRRAGSAGgalQTGQRVGSAIG----IAAVGSVFFGRLADdgWSNAYDHGLIVSVGFVIAALLVAV 471
Cdd:COG2807 325 LT-LIGLRARTPA---EAAALSGMAQSvgylLAALGPLLVGALHD--ATGSWTAALLLLAALAVLMLVAGL 389
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
64-223 |
2.23e-14 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 74.56 E-value: 2.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 64 LSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGvaGGLVSPQITALIQQMFRGR 143
Cdd:cd17472 38 LGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG--SGAISSVVMALLADLTREE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 144 ERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGAdegwRWVFYVNLPIGVLCLVLAHRLLPDTPGARGVRLRELDPLGVLL 223
Cdd:cd17472 116 NRTKAMALIGASIGIAFAISMVLGPLLAAHLGV----SGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLL 191
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
62-439 |
3.07e-14 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 73.77 E-value: 3.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 62 WVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPqITALIQQMFR 141
Cdd:cd17330 38 LLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSV-AQAYIADITD 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 142 GRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGAdegwRWVFYVNLPIGVLCLVLAHRLLPdtpgargvrlreldPLGV 221
Cdd:cd17330 117 EEERAKAFGIISAAFGLGFILGPALGGFLSTPYGY----ALPFLVAAALALLNLVLVLFFLP--------------PLRR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 222 LLLGAGVVALLlpfvqsrqwpgdekylllvvaaallaafawwerrctrsgaeplldlalyrvrsyslgsalgllyFAGFT 301
Cdd:cd17330 179 LLLVYFLIALA----------------------------------------------------------------FAGLE 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 302 SIFFvstLYLQSGLHYTALQAGLTLTPFALGSGLS-AGIGGRLVDRLG-RPLVVAGLLMVAIGLAGTAFAvhqvtgkGIG 379
Cdd:cd17330 195 SVFS---LFLKDRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGeRKLLRLGLLLAIIGLLLLPFA-------SSV 264
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 380 WALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIGIAAVGSVF 439
Cdd:cd17330 265 PLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLY 324
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
76-444 |
1.69e-13 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 72.73 E-value: 1.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 76 VPSGRLGDARGRRRVFMAGLVLFTLasaacGAAQSSLwlviSRLVQGVAGGLVSPQI----TALIQQMFRG-----RERG 146
Cdd:cd17322 55 PPYAKLSDVFGRLELFLVSLLLYVV-----GTIIMAA----STNVQTYAAGSVFYNAgytgLNLLLTLILAdfsslKNRG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 147 KAFGAFGSVVGISTavgpLLGGLLIQAAGADEGWRWVF--------YVNLPIgVLCLVLAHR------LLPDTPGARGVR 212
Cdd:cd17322 126 FASAIPSLPYIITT----WIGGNIAQAALPNSNWRWGYgmwaiilpLSSLPL-VLCLLYMQRkarkdgEIKELKNQETEE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 213 LR------------ELDPLGVLLLGAGVVALLLPFVQSRQ----WPGDEKYLLLVVAAALLAAFAWWERRCTRSgaePLL 276
Cdd:cd17322 201 QTgglsqnlvklfwKLDIFGVILLTAGLGLILVPLTLAGGakskWKNSSIIAMIVLGGVLLVAFLLWEAKFAKY---PFL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 277 DLALYRVRSYSLGSALGLLYFAGF--TSIFFVStlYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLGR--PLV 352
Cdd:cd17322 278 PFRLLKDRTILAACLIDFFYFFSYyiFSDYLYT--VLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRRykVLV 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 353 VAGLLMVAIGLAGTAFAVHQVTGKGigwALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIGI 432
Cdd:cd17322 356 IIGVPLYIVGMGLLIRYRGGSGSHG---GIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGA 432
|
410
....*....|..
gi 2764013522 433 AAVGSVFFGRLA 444
Cdd:cd17322 433 AISGAIWTQTLP 444
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
45-205 |
1.35e-12 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 69.17 E-value: 1.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 45 ALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVA 124
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 125 GGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNLPIGVLCLVLAHRLLPD 204
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWF----SWHAIFWVLALAAILAAALVFFFIPE 168
|
.
gi 2764013522 205 T 205
Cdd:PRK11102 169 T 169
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
27-206 |
2.02e-11 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 65.67 E-value: 2.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 27 VCLVAGFMTLL---DVSIVNVALPSIRTGLDTPESDLQWVLSGYAL--AFGLFLvpSGRLGDARGRRRVFMAGLVLFTLA 101
Cdd:cd17359 2 ISLVAALGGLLfgyDTGVINGALPFLQTDFNLTPFLEGLVVSSALLgaAIGALF--AGRLADRFGRRKTLLISAVLFFIS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 102 SAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFG--AFGSVVGISTA--VGPLLGGLLIQAAGAD 177
Cdd:cd17359 80 ALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSlnQLMIVFGQLLAyiVNYLIANAGGADWLGA 159
|
170 180
....*....|....*....|....*....
gi 2764013522 178 EGWRWVFYVNLPIGVLCLVLAHRlLPDTP 206
Cdd:cd17359 160 EGWRWMLGLEAIPAILFLLGMLF-IPESP 187
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
78-472 |
3.38e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 64.92 E-value: 3.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 78 SGRLGDARGRRRVFM-AGLVLFTLASAACGAAQSS------LWLVISRLVQGVAGGLVSPQITALIQQMFRG-RERGKAF 149
Cdd:COG2211 70 SDRTRTRWGRRRPWIlIGAIPLALSFVLLFTAPDLsptgklIYALVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLS 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 150 GAFGSVVGISTAVGPLLGGLLIQAAGADE--GWRWVFYVnlpigvlclvlahrllpdtpgargvrlreldplgvlLLGAG 227
Cdd:COG2211 150 SWRFAFAGLGGLLASVLPPPLVAAFGGDAalGYRLTALI------------------------------------FAVLG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 228 VVALLLPFvqsrqwpgdekylllvvaaallaaFAWWERRCTRSGAEPLLDL--ALYRVRSYSLGSALGLLYFAGFTSIFF 305
Cdd:COG2211 194 LLAFLLTF------------------------FGTKERPVPEEEKVSLKESlkALLKNRPFLLLLLAYLLFFLALALVAA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 306 VSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLG-RPLVVAGLLMVAIGLAGTAFAvhqvtGKGIGWALIA 384
Cdd:COG2211 250 LLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGkKKAFIIGLLLAALGLLLLFFL-----GPGNLWLLLV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 385 PLLFAGLGSGLVispnQTLTLSEVP-----------VRRAGSAGGALQTGQRVGSAIGIAAVGSV--FFGRLADDGWSNA 451
Cdd:COG2211 325 LAALAGIGLGAI----LVLPWAMLAdvvdydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLlaLFGYVAGAAQSPS 400
|
410 420
....*....|....*....|.
gi 2764013522 452 YDHGLIVSVgFVIAALLVAVA 472
Cdd:COG2211 401 ALTGIRLLF-FLLPAVLLLLA 420
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
37-214 |
8.34e-11 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 63.48 E-value: 8.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 37 LDVSIVNVALPSIRT--GLDTPESDL--QWVLSGYAlAFGLFlvpSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSL 112
Cdd:cd17371 13 FDLLLLGLVLPALIAefGLDEAEAGLlgTVTLAGGA-IGGIL---GGILADRFGRVRVLVITILLFAVFTLLCGFAQNYW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 113 WLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGADEGWRWVFYVNLpIGV 192
Cdd:cd17371 89 QLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGA-LPA 167
|
170 180
....*....|....*....|..
gi 2764013522 193 LCLVLAHRLLPDTPGARGVRLR 214
Cdd:cd17371 168 LLVLFIRRFVKEPPQWQAARAA 189
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
26-196 |
1.06e-10 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 62.96 E-value: 1.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 26 AVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAAC 105
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 106 G-AAQSSLW-LVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIqaagADEGWRWV 183
Cdd:cd17380 82 PlLAYSSLPlLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLL----EYYGWPSV 157
|
170
....*....|...
gi 2764013522 184 FYVnlpIGVLCLV 196
Cdd:cd17380 158 FYF---FGLLGLL 167
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
21-201 |
1.09e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.97 E-value: 1.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 21 RWKALAVCLVAGFMTLLDVSIVNVALPSI-RTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDAR-GRRRVFMAGLVLF 98
Cdd:cd17474 196 RGRGLLTFLVSAFLYFFLYFAFLTYLPFLlELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRfGARRILVIGLLLY 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 99 TLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGade 178
Cdd:cd17474 276 ALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG--- 352
|
170 180
....*....|....*....|...
gi 2764013522 179 gWRWVFYVNLPIGVLCLVLAHRL 201
Cdd:cd17474 353 -LSAPFLVGAAIALAAAVLLALL 374
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
30-436 |
1.17e-10 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 63.12 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 30 VAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQ 109
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 110 SSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAV-GPLLGGLLIQaagadEGWRWVFYVNL 188
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIgGPLVGWILIH-----FSWQWAFIIEG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 189 PIGVLCLVLAHRLLPDTPGARGVRLRELDPLgvlllgagVVALLLPFVQSRQWPGDEKYLLLvvaaallaafawwerrct 268
Cdd:TIGR00893 156 VLGIIWGVLWLKFIPDPPQKAKWLTEEEKYI--------VVGGLLAEQQGKGPSTPKKYQIK------------------ 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 269 rsgaEPLLDLALYRVRSYSLGSALGLLYFAGFTSiffvstLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLG 348
Cdd:TIGR00893 210 ----ELLKDRRVWGLALGQFLVNIGLGFFLTWFP------TYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 349 R---PLVVAgLLMVAIGLAGTAFAVHQVTGKGIGWALIAPLLFAGLGSGLVISPnQTLTLSEVPVRRAGSAGGALQTGQR 425
Cdd:TIGR00893 280 RrgkSLVFA-RKTAIIAGLVLSLLMFATNYVNIPYAALALVALGFFGLGAGAIG-WALISDNAPGNIAGLTGGLINSLGN 357
|
410
....*....|.
gi 2764013522 426 VGSAIGIAAVG 436
Cdd:TIGR00893 358 LGGIVGPIVIG 368
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
25-203 |
1.37e-10 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 63.02 E-value: 1.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 25 LAVCLVAgfMTLLDVSIVNVALPSIRTGLDTPESDLQW-------VLSGYALAFGLFLVPSGRLGDARGRRRVFMAGL-- 95
Cdd:cd17318 18 LSVAIVA--MVNSTATHDNNNTSTDKDTLPVEAPEFDWsektqgiILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSIli 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 96 -VLFTLASAACgAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAA 174
Cdd:cd17318 96 tALLTLLTPLA-ARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESL 174
|
170 180
....*....|....*....|....*....
gi 2764013522 175 gadeGWRWVFYVNLPIGVLCLVLAHRLLP 203
Cdd:cd17318 175 ----GWPSIFYIFGGLGLLWCLLWFFLVL 199
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
43-206 |
1.72e-10 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 62.68 E-value: 1.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 43 NVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQG 122
Cdd:cd17312 23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 123 VAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNLPIGVLCLVLAHRLL 202
Cdd:cd17312 103 LFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY----GWRAAFLVPGIVGLVVAIILFFFL 178
|
....
gi 2764013522 203 PDTP 206
Cdd:cd17312 179 RDSP 182
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
29-436 |
1.75e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 62.63 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 29 LVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMA-----GLVLFTLASA 103
Cdd:cd06173 5 WLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 104 ACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGAdegwRWV 183
Cdd:cd06173 85 ALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP----GGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 184 FYVNlpigvlclvlahrllpdtpgargvrlreldplGVLLLGAGVVALLLPFvqsrqwpgDEKYLLLVVAAALLAAFAWW 263
Cdd:cd06173 161 FAIN--------------------------------ALSFLLSALLLLFIRR--------PPPAAPGESSSLLLRDLREG 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 264 ERRCTRSGaeplldlalyRVRSYSLGSALGLLYFAGFTSIFfvsTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRL 343
Cdd:cd06173 201 LRYLRRSP----------LLRLLLLALALFALLGGALTVLL---PLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 344 VDRLGR-PLVVAGLLMVAIGLAGTAFAVHqvtgkgiGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQT 422
Cdd:cd06173 268 SKRRRRgRLLLIGALLLGLALLVLGLSPS-------LWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNA 340
|
410
....*....|....
gi 2764013522 423 GQRVGSAIGIAAVG 436
Cdd:cd06173 341 LNSGAMPLGALLAG 354
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
42-469 |
1.76e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 62.64 E-value: 1.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 42 VNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQ 121
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 122 GVAGGLVSPQITALIQQMFRGRERGKAFGafgsVVGISTAVGPLLGGLLIQAAGADEGWRWVFYVNLPIGVLCLVLAHRL 201
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMG----IRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 202 LPDTPGARGVRLRELDPLgvlllgagvvalllpfvqsrqwpgdekylllvvaaallaafawwerrctRSGAEPLLDLALY 281
Cdd:cd17475 171 YREPPAASAATESASTLL-------------------------------------------------RSLKEVLRNRDVW 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 282 RVrsyslgSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLGRPLVVAGLLMVAI 361
Cdd:cd17475 202 LI------AIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAA 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 362 GLAGTAFAVHQVTGKGIGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGsaigiAAVGSVFFG 441
Cdd:cd17475 276 IAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIG-----IAIGPPLFG 350
|
410 420
....*....|....*....|....*...
gi 2764013522 442 RLADdgWSNAYDHGLIVSVGFVIAALLV 469
Cdd:cd17475 351 LLVD--ATHSYAPAWLALALLLVLAALL 376
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
62-468 |
1.79e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 62.63 E-value: 1.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 62 WVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFR 141
Cdd:cd17329 39 LVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTT 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 142 GRERGKAFGAFGSVVGISTAVGPLLGGLLIQAagadeGWRWVFYVNLPIGVLCLVLAHRLLPDTPGARGVRLRELDPLGV 221
Cdd:cd17329 119 PENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-----SFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGY 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 222 LLLGagvvalllpfvqsrqwpgdekylllvvaaallaafawwerrctrsgaeplldlalyRVRSYSLGSALGLLYFAGFT 301
Cdd:cd17329 194 KIVL--------------------------------------------------------RDRAFLLFLLASFLISLIYF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 302 SIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLG-RPLVVAGLLMVAIGLAGTAFAVHQvtgkgigW 380
Cdd:cd17329 218 QLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRlRKILMIGILLFAIGFAVLAFANTL-------A 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 381 ALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIGIAAVGSVFFGRLADDGWsnaydhGLIVSV 460
Cdd:cd17329 291 VLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW------LILAAL 364
|
....*...
gi 2764013522 461 GFVIAALL 468
Cdd:cd17329 365 GLIAAALL 372
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
63-202 |
3.69e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.46 E-value: 3.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 63 VLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRG 142
Cdd:cd17489 232 FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPP 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 143 RERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNLPIGVLCLVLAHRLL 202
Cdd:cd17489 312 HRRGAANGTFFIFFDLGIGLGGLLLGLVAELF----GYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
24-222 |
1.41e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 59.98 E-value: 1.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 24 ALAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSgyALAFGLFL--VPSGRLGDARGRRRVFMAGLVLFTLA 101
Cdd:PRK11551 16 TIGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFS--AGILGLLPgaLLGGRLADRIGRKRILIVSVALFGLF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 102 SAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLliqaAGADEGWR 181
Cdd:PRK11551 94 SLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVL----AAGDAAWR 169
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 2764013522 182 WVFYVNLPIGVLCLVLAHRLLPDTPGARGVRLRELDPLGVL 222
Cdd:PRK11551 170 HIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRAPVL 210
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
62-206 |
3.31e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.34 E-value: 3.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 62 WVLSGYALAFGLFLVPSGRLGDARGRRR--VFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQM 139
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2764013522 140 FRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGadegWRWVFYVNLPIGVLCLVLAHRLLPDTP 206
Cdd:COG2271 300 FPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG----YQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
63-176 |
3.41e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 58.32 E-value: 3.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 63 VLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRG 142
Cdd:cd17370 239 LYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPA 318
|
90 100 110
....*....|....*....|....*....|....
gi 2764013522 143 RERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGA 176
Cdd:cd17370 319 ELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISP 352
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-199 |
4.14e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 58.21 E-value: 4.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 20 NRWKALAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGD-ARGRRRVFMAGLVLF 98
Cdd:cd06174 201 KNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLM 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 99 TLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGade 178
Cdd:cd06174 281 ALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF--- 357
|
170 180
....*....|....*....|.
gi 2764013522 179 GWRWVFYVNLPIGVLCLVLAH 199
Cdd:cd06174 358 GLTGAFLVLAVLLLLAAILLL 378
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
59-213 |
4.24e-09 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 58.41 E-value: 4.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 59 DLQWV---LSGYaLAFGLFL-VPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITA 134
Cdd:PRK15402 46 GAEWVptsMTAY-LAGGMFLqWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYA 124
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2764013522 135 LIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNLPIGVLCLVLAHRLLPDTPGARGVRL 213
Cdd:PRK15402 125 AIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVL----PWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKL 199
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
45-203 |
4.39e-09 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 58.37 E-value: 4.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 45 ALPSIRTGLDTPES----DLQWVLSGYALAFGLFlvpsGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLV 120
Cdd:PRK11043 28 AFKAIQADLQTSASavsaSLSLFLAGFALGQLLW----GPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 121 Q--GVAGGLVSPQitALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQaagaDEGWRWVFYVNLPIGVLCLVLA 198
Cdd:PRK11043 104 QavGVCSAAVIWQ--ALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLN----HFGWQAIFATLFAITLLLILPT 177
|
....*
gi 2764013522 199 HRLLP 203
Cdd:PRK11043 178 LRLKP 182
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
79-186 |
4.63e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 58.04 E-value: 4.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 79 GRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGI 158
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYL 340
|
90 100
....*....|....*....|....*...
gi 2764013522 159 STAVGPLLGGlliqAAGADEGWRWVFYV 186
Cdd:cd17391 341 GNVAGPLLGS----AIAAHFGYRAVFVV 364
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
43-218 |
5.33e-09 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 57.77 E-value: 5.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 43 NVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAqSSLW-LVISRLVQ 121
Cdd:TIGR00881 15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS-TSLWvMAALWALN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 122 GVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGadeGWRWVFYVNLPIGVLCLVLAHRL 201
Cdd:TIGR00881 94 GIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELY---SWHWVFIVPGIIAIIVSLICFLL 170
|
170
....*....|....*..
gi 2764013522 202 LPDTPGARGVRLRELDP 218
Cdd:TIGR00881 171 LRDSPQSCGLPPAEEMP 187
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
292-487 |
8.16e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.04 E-value: 8.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 292 LGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLG-RPLVVAGLLMVAIGLAGTAFAV 370
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGrRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 371 HQvtgkgigWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIGiAAVGSVFFGRLaddGWSN 450
Cdd:pfam07690 84 SL-------WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALG-PLLGGLLASLF---GWRA 152
|
170 180 190
....*....|....*....|....*....|....*..
gi 2764013522 451 AYdhgLIVSVGFVIAALLVAVADVVAGHREKGAGQAR 487
Cdd:pfam07690 153 AF---LILAILSLLAAVLLLLPRPPPESKRPKPAEEA 186
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
27-206 |
9.37e-09 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 57.26 E-value: 9.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 27 VCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACG 106
Cdd:cd17327 10 LCILYFLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 107 AAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLG-GLL-IQAAGADEGWRWVF 184
Cdd:cd17327 90 AVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAyGVFkILGVGGLAGWRWLF 169
|
170 180
....*....|....*....|..
gi 2764013522 185 YVNLPIGVLCLVLAHRLLPDTP 206
Cdd:cd17327 170 IIEGLITIIIGLVIFFWLPDNP 191
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
291-436 |
9.56e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.91 E-value: 9.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 291 ALGLLYFAGFTSIFFVSTL--YLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLGR-PLVVAGLLMVAIGLAGTA 367
Cdd:COG2814 14 ALALGAFLSGLGIGIVLPAlpLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRrRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2764013522 368 FAVHqvtgkgiGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIGIAAVG 436
Cdd:COG2814 94 LAPS-------LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGG 155
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
21-198 |
1.06e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.85 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 21 RWKALAVCLVAGFMTLLDVSIVNVALPSI-RTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFT 99
Cdd:cd06173 206 RSPLLRLLLLALALFALLGGALTVLLPLLaKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 100 LASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGAdeg 179
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL--- 362
|
170
....*....|....*....
gi 2764013522 180 wRWVFYVnlpIGVLCLVLA 198
Cdd:cd06173 363 -SAVFLL---AGALLLLAA 377
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
50-399 |
1.06e-08 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 57.27 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 50 RTGLDTPESDLQW--VLSGYAL--AFGLFLVPSgrLGDARGRRRVFMAGLVLFTLASA---ACGAAQSSLWLVISRLVQG 122
Cdd:cd17357 39 GLNLSDSELDLLWslIVSIFFIggAIGSFISAF--LANRFGRKNGLLISNALLVVSSLlmfLSKSAKSPELLIFGRFLVG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 123 VAGGLVSPqitalIQQMFRGRERGKAF-GAFGSVVGISTAVGPLLGGL--LIQAAGADEGWRWVFYVNLPIGVLCLvLAH 199
Cdd:cd17357 117 IACGLSTG-----FVPMYLQEISPSELrGALGSLTQIGVTLGILLGQVfgLPSVLGTETLWPYLLFFPGIPALLQL-AAL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 200 RLLPDTPgargvrlreldplGVLLLGAGVVALLLPFVQSRQWPGDEKYLLLVVAAAllaafawWERRCTRSGAEPLLDla 279
Cdd:cd17357 191 PFFPESP-------------KFLLISKGDEEEAEKSLKFLRGIEDDVDQELEEIKK-------ESEQMGDQKQVSLMQ-- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 280 LYRVRSYSLGSALGLLY-----FAGFTSIFFVST-LYLQSGLHYTALQagltLTPFALG--SGLSAGIGGRLVDRLGR-P 350
Cdd:cd17357 249 LLRDPSLRLPLLLVLVVsasqqFSGINAIFFYSTfIFENAGFSPQLAE----WANLGIGivNVLSTIVGPFLIEKVGRrP 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2764013522 351 LVVAGLLMVAIGL---AGTAFAVHQVTgkGIGWALIAPLLFAGLGSGLVISP 399
Cdd:cd17357 325 LLLISLSVCAVALllmSVFLFLSEQNS--WMSYGCIVAIFLFIFFFAIGLGP 374
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
25-198 |
1.73e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 56.05 E-value: 1.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 25 LAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAA 104
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 105 CGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVF 184
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAF----GWRSVF 156
|
170
....*....|....
gi 2764013522 185 YVNLPIGVLCLVLA 198
Cdd:cd17365 157 LLGGVPPLILLPLL 170
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
63-201 |
2.44e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.04 E-value: 2.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 63 VLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWL-VISRLVQGVAGGLVSPQITALIQQMFR 141
Cdd:COG2223 246 LAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLfLVLFLLLGLALGGGNGAVFALVPDIFP 325
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 142 GRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGadeGWRWVFYVNLPIGVLCLVLAHRL 201
Cdd:COG2223 326 TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG---SYTAAFLVFAVLALVALVLTLLL 382
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
29-206 |
2.68e-08 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 56.13 E-value: 2.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 29 LVAGFMTLLDVSIVNVALPSiRTGLDTPESDLQWVLSGYAL--AFGLFLVpsGRLGDARGRRRVFMAGLVLFTLASAACG 106
Cdd:pfam00083 18 VIGAFLTLIDFFKNFGLSKS-VSSLAALSVLSGLIVSIFSVgcFIGSLFA--GKLGDRFGRKKSLLIANVLFVIGAVLQG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 107 AA--QSSLW-LVISRLVQGVAGGLVSPQITALIQQMFRGRERgkafGAFGSVVGISTAVGPLLG---GLLIQAAGADEGW 180
Cdd:pfam00083 95 AAkgKWSVYqLIVGRVLVGIGVGGASVLAPMYISEIAPKKLR----GALGSLYQLAITFGILLAyifGLGLNKTSNSDGW 170
|
170 180
....*....|....*....|....*.
gi 2764013522 181 RWVFYVNLPIGVLCLVLAHrLLPDTP 206
Cdd:pfam00083 171 RIPLGLQLVPALLLIIGLL-FLPESP 195
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
29-471 |
3.36e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 55.26 E-value: 3.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 29 LVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAA 108
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 109 QSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLlggLLIQAAGADEGWRWVFYVNL 188
Cdd:cd17477 82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPL---LLALVGTAGALPFLIAAVLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 189 PIGVLCLVLAHRLLPDTPGARGVRLRELDPLGVLLLGAGVVAlllpfvqsrqwpgdekylllvvaaallaafawwerrct 268
Cdd:cd17477 159 LLALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVA-------------------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 269 rsgaeplldlalyrvrSYSLGSALGLLyfagftsiffvsTLYLQSgLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLG 348
Cdd:cd17477 201 ----------------GFLEGAFYSLL------------PLYGLR-LGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFD 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 349 RPLVvagllMVAIGLAGTAFAVHQVTGKGIGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGS 428
Cdd:cd17477 252 RRRV-----LLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGS 326
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 2764013522 429 AIGIAAVGSV--FFGrladdgwsnayDHGLIVSVGFVIAALLVAV 471
Cdd:cd17477 327 VIGPLLAGALmdAFG-----------PHGLFLFLAAVALLFLLFL 360
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
22-472 |
3.43e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 55.35 E-value: 3.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 22 WKALAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLA 101
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 102 SAACGAAQSSLWLVISRLVQGVAG-GLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGW 180
Cdd:cd17355 82 LVLLALATSLWQLYLLWGLLGGGGaGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAF----GW 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 181 RWVFYVnlpigvlclvlahrllpdtpgargvrlreldpLGVLLLGAGVVALLLPfvqsRQWPGDEKYLLLVVAAALLAAF 260
Cdd:cd17355 158 RTALLV--------------------------------LALLALLVLVPVLLLL----RRRPADLALRAYDDASPASPGS 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 261 AWweRRCTRSGAEPLLDLAlyrvrsyslgsalglLYFAGFTSIFFVSTL--YLQSgLHYTALQAGLTLTPFALGSGLSAG 338
Cdd:cd17355 202 TL--KEALRSASFWLLALA---------------FFLCGFAVVGLIVHLvpYLAD-RGISPAAAAVALALIGLFNIVGRL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 339 IGGRLVDRLGRPLVVAGL-LMVAIGLAGTAFavhqvtGKGIGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAG 417
Cdd:cd17355 264 LSGWLGDRYSPRRLLAASyALRALGLALLLL------LPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLF 337
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 2764013522 418 GALQTGQRVGSAIGiAAVGSVFFGRLADDGWSnaydhgLIVSVGFVIAALLVAVA 472
Cdd:cd17355 338 GLVFAPHQLGSALG-PWLGGLLYDRTGSYTAA------WALAVALGLIAALLVLP 385
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
288-472 |
3.54e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 55.26 E-value: 3.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 288 LGSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLG-RPLVVAGLLMVAIGLAGT 366
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGrRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 367 AFAVHqvtgkgiGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIGIAAVGSVffgrLADD 446
Cdd:COG2271 93 GFATS-------FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL----LAAF 161
|
170 180
....*....|....*....|....*.
gi 2764013522 447 GWSNAYDHGLIVSVGFVIAALLVAVA 472
Cdd:COG2271 162 GWRAAFLILGLPGLLLALLRFWLLAL 187
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
293-471 |
5.48e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 54.93 E-value: 5.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 293 GLLYFAGFTSIFFVsTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLGR-PLVVAGLLMVAIGLAGTAFAvh 371
Cdd:cd17329 9 FLNRLGFFMVWPFM-AIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRkPVMLAGLLLRALGFALLGFA-- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 372 qvtgkGIGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIGIAAVGSvffgrLADDGWSNA 451
Cdd:cd17329 86 -----HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGL-----LLLYSFRLL 155
|
170 180
....*....|....*....|
gi 2764013522 452 YdhgLIVSVGFVIAALLVAV 471
Cdd:cd17329 156 F---LAAAVLFLLAALVLLF 172
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
23-179 |
1.17e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.14 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 23 KALAVCLVAGFMTLLDVSIVNVALP-SIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLA 101
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 102 SAACGAAQ--SSLWLVISRLVQGVAGGLVSPQITALI-------QQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQ 172
Cdd:COG2211 308 LLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLadvvdydEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
....*..
gi 2764013522 173 AAGADEG 179
Cdd:COG2211 388 LFGYVAG 394
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
45-205 |
1.22e-07 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 53.76 E-value: 1.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 45 ALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVA 124
Cdd:PRK11652 30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 125 GGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNLPIGVLCLVLAHRLLPD 204
Cdd:PRK11652 110 TGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLF----GWRACYLFLLLLGAGVTFSMARWMPE 185
|
.
gi 2764013522 205 T 205
Cdd:PRK11652 186 T 186
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
62-476 |
1.75e-07 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 53.41 E-value: 1.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 62 WVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQiTALIQQMFR 141
Cdd:cd17388 42 VLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVA-AAYIADVTP 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 142 GRERGKAFGAFGSVVGISTAVGPLLGGLLiqaagADEGWRWVFYVNLPIGVLCLVLAHRLLPDT--PGARGVRL-RELDP 218
Cdd:cd17388 121 PEQRARNFGLLGAAFGLGFIAGPALGGLL-----GEISPRAPFLVAAGLNGLNFLLGLFVLPESlpPERRRAFRwRRANP 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 219 LGvlllgagvvalllPFVQSRQWPGdekylllvvaaallaafawwerrctrsgaepLLDLALyrvrsyslgsALGLLYFA 298
Cdd:cd17388 196 FG-------------SLRWLTGFPG-------------------------------LLGLLA----------VFFLIQLI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 299 GfTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLS-AGIGGRLVDRLG-RPLVVAGLLMVAIGLAGTAFAVHqvtgk 376
Cdd:cd17388 222 G-QVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFqAFVTGPIAKRLGeKRAILLGLAADALGFLLLAFATQ----- 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 377 giGWALIAPLLFAGLGsGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIGIAAVGSVFFgrladdgWSNAYDHGL 456
Cdd:cd17388 296 --GWMVFPILILLALG-GIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFA-------ASPATWPGL 365
|
410 420
....*....|....*....|
gi 2764013522 457 IvsvgFVIAALLVAVADVVA 476
Cdd:cd17388 366 A----WIIGAALYLICLVLA 381
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
79-445 |
2.81e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.56 E-value: 2.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 79 GRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGReRGKAFGAFGSVVGI 158
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 159 STAVGPLLGGLLIQAAGAdEGWRWVFyvnLPIGVLCLVLAHRLLPDTPGARGVRLRELDPLGVLLLGAGVVALLLPFVQS 238
Cdd:cd17478 131 GFALGPLIAAALVALFGG-LGLLILL---IIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 239 RQWpgdekylllvvaaallaafawwerrctrsgaeplldlalyrvrsyslgsalgllYFAGFTSifFVSTLYLQSGlhYT 318
Cdd:cd17478 207 RSW------------------------------------------------------VLSSLTT--FLPFYLVQRG--YS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 319 ALQAGLTLTPFALGSGLSAGIGGRLVDRLGR-PLVVAGLLMVAIGLAGTAFAVhqvtgkgiGWALIAPLLFAGLGSGLVI 397
Cdd:cd17478 229 LVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRrRVIIASLLLAAPFLLLFLLTP--------GIWSYILLVLAGFLLFASF 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2764013522 398 SPNQTLTLSEVPvRRAGSAGGALqtgqrVGSAIGIAAVGSVFFGRLAD 445
Cdd:cd17478 301 PVTVVLAQELLP-GNVGLASGLM-----MGLSFGLGGIGAPVLGALAD 342
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
53-202 |
3.28e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 52.23 E-value: 3.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 53 LDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQI 132
Cdd:cd17329 231 LGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAV 310
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 133 TALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGAdegwRWVFYVnlpIGVLCLVLAHRLL 202
Cdd:cd17329 311 QTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGP----GLPWLI---LAALGLIAAALLL 373
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
298-431 |
3.96e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 52.27 E-value: 3.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 298 AGFTSIFFVSTLYLQSGLHYTALQ----AGLTLTPFALGSGLSAGIGGRLVDRLGR-PLVVAGLLMVAIGLAGTAFaVHQ 372
Cdd:cd17391 10 IGFSLIAPFLPLYIEQLGVTSGGLvelwSGLAFSSTFLVSAIFSPIWGRLADRYGRkPMLLRASLGMAIVIGLMAF-VTN 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2764013522 373 VtgkgigWALIAPLLFAGLGSGLvISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIG 431
Cdd:cd17391 89 V------WQLLILRLLQGVFSGY-VPNATALIASQTPKEKSGWALGTLSTGVVAGTLIG 140
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
79-204 |
8.29e-07 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 51.07 E-value: 8.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 79 GRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSpqIT-ALIQQMFRGRERGKAFGAFGSVVG 157
Cdd:cd17390 52 GSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQS--LCkAYLSDLVSEQERSRVLGRFNAASS 129
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 2764013522 158 ISTAVGPLLGGLLIQAAGadeGWRWVFYVNLPIGVLCLVLAHRLLPD 204
Cdd:cd17390 130 LGFILGPVVGGHLAETDG---GFYYVALLCSAIFILNAGLVWFLLSK 173
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
66-469 |
1.04e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 50.62 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 66 GYALAFGLFLVpSGRLGDARGRRRVFM-AGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRE 144
Cdd:cd17370 43 AEALGSLLRLF-SGYLSDRTGKRKPLViLGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 145 RGKAFGAFGSVVGISTAVGPLLGGLLIQAAGadEGWRWVFYVNLPIGVLCLVlahrllpdtpgargvrlreldplgvlll 224
Cdd:cd17370 122 RGKAFGLHRALDTLGAVLGPLLAALLLYLLG--GNYRTIFLLAAIPALLALL---------------------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 225 gagvvaLLLPFVQSRQWPGDEKYLLLVVAAALLAAFAWWerrctrsgaeplldlalyrvrsyslgsALGLLYFAGFTSIF 304
Cdd:cd17370 172 ------ILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWL---------------------------YLLAVALFALGNFS 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 305 FVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLGR-PLVVAGLLMVAIGLAGTAFAVHQvtgkgigWALI 383
Cdd:cd17370 219 FAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRkKLLILGYLSLALAYLGFALGSSL-------WLLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 384 APLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIgiaavGSVFFGRLADDGWSNAydhGLIVSVGFV 463
Cdd:cd17370 292 LGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLL-----ASLIAGYLWDLISPSA---AFLFSAVLA 363
|
....*.
gi 2764013522 464 IAALLV 469
Cdd:cd17370 364 LIALLL 369
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
44-209 |
1.22e-06 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 50.79 E-value: 1.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 44 VALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGV 123
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 124 AGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNLPIGVLCLVLAHRLLP 203
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKF----PWQSLFYTMAAMGILVLLLSLFILK 179
|
....*.
gi 2764013522 204 DTPGAR 209
Cdd:PRK10473 180 ETRPAR 185
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
28-441 |
1.45e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 50.34 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 28 CLVAGFMTLLDVSIVNVALP-SIRTGLDTPESDLQwVLSGYA-----LAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLA 101
Cdd:cd17391 1 CWLGNFFTGIGFSLIAPFLPlYIEQLGVTSGGLVE-LWSGLAfsstfLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 102 SAACGAAQSSLWLVISRLVQGVAGGLVsPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWR 181
Cdd:cd17391 80 IGLMAFVTNVWQLLILRLLQGVFSGYV-PNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLF----GIR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 182 WVFYVnlpigvlclvlahrllpdtpgargvrlreldpLGVLLLGAGVVALLlpFVQsrqwpgdEKYLLLVVAAALLAAFA 261
Cdd:cd17391 155 NVFFI--------------------------------TGGLLFLAFLLTLF--FVK-------EDFKPVEKKKMVSTKEV 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 262 WwerrctRSGAEPLLDLALYrvrsyslgsALGLLYFAGFTSIFFVSTLYLQS---GLHYTALQAGLTLTPFALGSGLSAG 338
Cdd:cd17391 194 W------NSVPNPSLLISLF---------VTTFIIQLANQSIEPILTLYIRQlmgDASNLAFISGLVFSATGVSSLLSAP 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 339 IGGRLVDRLG-RPLVVAGLLMVAIGLAGTAFAvhqvtgkGIGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAG 417
Cdd:cd17391 259 RLGKLGDRIGhHRILLGALLASALLYIPQAFV-------QTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIF 331
|
410 420
....*....|....*....|....*.
gi 2764013522 418 GALQTGQRVGSAIG--IAAVGSVFFG 441
Cdd:cd17391 332 GYNQSFQYLGNVAGplLGSAIAAHFG 357
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
294-488 |
1.49e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 50.29 E-value: 1.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 294 LLYFAGFTSIFFVSTLYLQsGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLGR-PLVVAGLLMVAIGLAGTAFAVhq 372
Cdd:cd17489 6 FFFFLSFYLLLPVLPLYAH-DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRkRLLLIGLLIFALATLLYLLAT-- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 373 vtgkGIgWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIGiAAVGSVFFGRladdgwsnaY 452
Cdd:cd17489 83 ----SV-ALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALG-PALGLFLYQH---------L 147
|
170 180 190
....*....|....*....|....*....|....*.
gi 2764013522 453 DHGLIVSVGFVIAALLVAVADVVAGHREKGAGQARA 488
Cdd:cd17489 148 GFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEA 183
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-164 |
1.51e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.11 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 28 CLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRR---VFMAGLVLFTLASAA 104
Cdd:pfam07690 205 LLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLILAALGLLL 284
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 105 CGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGP 164
Cdd:pfam07690 285 LSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
310-396 |
2.41e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 49.53 E-value: 2.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 310 YLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLG-RPLVVAGLLMVAIGLAGTAFAVHqvtgkgIGWALIAPLLF 388
Cdd:cd17353 28 PLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGpRKAILIGGILFGLGFILSAFAIS------LPLLFLGYGVL 101
|
....*...
gi 2764013522 389 AGLGSGLV 396
Cdd:cd17353 102 GGIGAGIG 109
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
27-472 |
3.01e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 49.17 E-value: 3.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 27 VCLVAGFMTLLDVSIVnvaLPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACG 106
Cdd:cd17341 6 LSFFLGFMVWFLFAPL---GPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 107 AAQSSLW-LVISRLVQGVAGGLVSPQITaLIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQA---AGADEGWRW 182
Cdd:cd17341 83 LAVSSYWgLLVLGFLLGFAGANFASGQP-WASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAivfDGGFVGWRN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 183 VFYVNLPIGVLCLVLAHRLLPDTPGARGVRLRELdplgvlllgagvvalllpfvqSRQWPGDEKYLllvvaaallaafAW 262
Cdd:cd17341 162 AFFVPGILLAIAAVLVLLFGDDLPTGKASALEFL---------------------KVQLAVLKNYR------------TW 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 263 WerrctrsgaeplldlalyrvrsyslgsaLGLLY---FAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGI 339
Cdd:cd17341 209 I----------------------------LSLLYgvtFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPA 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 340 GGRLVDRLGRPLVVAGLLMVAiGLAGTAFAVHQVTGKGIGWALIAPLLFAGLGSGLVispnQTLTLSEVPVRragsagga 419
Cdd:cd17341 261 GGWLSDRFGGRRRLWWLFIVM-TIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAG----NGSVFRMVPFI-------- 327
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 2764013522 420 lqTGQRVGSAIGIAAVGSVFFGRLADDGWSNAYDHGLIVSVGFVIAALLVAVA 472
Cdd:cd17341 328 --FRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVAC 378
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
30-206 |
3.33e-06 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 49.11 E-value: 3.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 30 VAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFL--VPSGRLGDARGRRRVFMAGLVLFTLASAACGA 107
Cdd:cd17315 4 LGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIgsLFGGPLADRFGRRKSLLIAAVLYVIGALLSAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 108 AQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERgkafGAFGSVVGISTAVGPLLGGL--LIQAAGADEGWRWVFY 185
Cdd:cd17315 84 APNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIR----GALGTLNQLMITFGILLAYLlgLALSLSPPGWWRLMFA 159
|
170 180
....*....|....*....|.
gi 2764013522 186 VNLPIGVLcLVLAHRLLPDTP 206
Cdd:cd17315 160 LAAVPALL-QLLLMFFLPESR 179
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
60-231 |
5.33e-06 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 48.67 E-value: 5.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 60 LQWVLsgyalafglflvpsGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQM 139
Cdd:PRK15403 67 LQWLL--------------GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 140 FRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNLPIGVLCLVLAHRLLPDTPGARGVRLRELDPL 219
Cdd:PRK15403 133 FGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFV----HWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSVL 208
|
170 180
....*....|....*....|.
gi 2764013522 220 G---------VLLLGAGVVAL 231
Cdd:PRK15403 209 RdfrnvfrnrLFLTGAATLSL 229
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
58-206 |
1.03e-05 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 47.82 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 58 SDLQ-WVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAAC--GAAQSSLWLVISRLVQGVAGGLVSPQITA 134
Cdd:TIGR00894 75 GALQgLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIpwAAGGGIALVVFCRVIQGLAQGSVSPATHK 154
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2764013522 135 LIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLiqaAGADEGWRWVFYVNLPIGVLCLVLAHRLLPDTP 206
Cdd:TIGR00894 155 IIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWL---CESWGGWPMIFYVFGIVGCAWSLLWFVFPADDP 223
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
45-218 |
2.30e-05 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 46.56 E-value: 2.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 45 ALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVA 124
Cdd:cd17343 25 VLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGLA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 125 GGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNLPIGVLCLVLAHRLLPD 204
Cdd:cd17343 105 QGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSY----GWRSTLSISGTVAVVMSVVCLLFIKN 180
|
170
....*....|....
gi 2764013522 205 TPGARGVRLRELDP 218
Cdd:cd17343 181 EPSDVGLNNIEEEE 194
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
69-403 |
2.31e-05 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 47.23 E-value: 2.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 69 LAFGLFLVPSGRLGDARGRRRV--FMAGL-VLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRER 145
Cdd:PRK08633 58 LPFLLLSSPAGFLADKFSKNRVirIVKLFeVGLTLLIVLAYYLGWFWLAFAVTFLLGAQSAIYSPAKYGIIPELVGKENL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 146 GKAFGAFGSVVGISTAVGPLLGGLLIQAAGADEGWRWVFYVnLPIGVLCLVLAhrllpdtpgargvrlreldplgvlLLG 225
Cdd:PRK08633 138 SRANGLLEAFTIVAILAGTALFSFLFESVNGNTPSEILGRI-APAGLVLLAVA------------------------VLG 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 226 AgVVALLLPFV-QSRQWPGDekylllvvaaallaafawweRRCTRSGAEPLLDLALYRVRSYSLGSALGLLYFagftsiF 304
Cdd:PRK08633 193 L-IFAYRLPKVpAAAPEVFD--------------------KKKYLFPKLLWRNLKLLRSDRVLWLAIIGLSYF------W 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 305 FVSTLYLQSGLHYTALQAGLTLT-----PFALgSGLSAGIGGRLVDRLGRPLVVAGLL-MVAIGLAGTAFAVHQVtgKGI 378
Cdd:PRK08633 246 FISQLAQANFPAYAKEVLGLDNTfqvqyLLAA-SAIGIGIGSLLAGRLSGRHIELGLVpLGALGLALSLFLLPTA--PSL 322
|
330 340
....*....|....*....|....*
gi 2764013522 379 GWALIAPLLFaGLGSGLVISPNQTL 403
Cdd:PRK08633 323 ASVLVLFFLF-GFSAGLFIVPLNAL 346
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
32-214 |
4.00e-05 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 45.72 E-value: 4.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 32 GFMTLLDVSIVNVALPSIRTGLDTPESDLQW---VLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAA 108
Cdd:cd17360 6 GFLFGYDTGVISGALLYIKDDLGEVVLSTGWqelIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 109 QSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGadeGWRWVFYVNL 188
Cdd:cd17360 86 PNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPG---GWRWMLGLAA 162
|
170 180
....*....|....*....|....*.
gi 2764013522 189 PIGVLCLVLAhRLLPDTPGARGVRLR 214
Cdd:cd17360 163 VPAVLQFIGL-LFLPESPRWPSTRRA 187
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
25-209 |
4.16e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.78 E-value: 4.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 25 LAVCLVAGFMTLLDVSIVnvaLPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAA 104
Cdd:cd17333 1 LYISFFSNGLTDALLGIL---GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 105 CGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFrGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGadeGWRWVF 184
Cdd:cd17333 78 IFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATSLLTSEL---SWSWAY 153
|
170 180
....*....|....*....|....*.
gi 2764013522 185 YVNLPIGVLCLVLAHRLL-PDTPGAR 209
Cdd:cd17333 154 LIIGLIYLLLAILILLTLfPELPSAR 179
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
72-206 |
4.63e-05 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 45.86 E-value: 4.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 72 GLFLvpsGRLGDARGRRRVFMAGLVLFTLASAACGAAQS----SLW----LVISRLVQGVAGGLVSPQITALIQQMFRGR 143
Cdd:PRK10642 74 GLFF---GMLGDKYGRQKILAITIVIMSISTFCIGLIPSyatiGIWapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDR 150
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2764013522 144 ERG--KAFGAFGSVVGISTAVG--PLLGGLLIQAAGADEGWRWVFYVNLPIGVLCLVLAHRlLPDTP 206
Cdd:PRK10642 151 KRGfmGSWLDFGSIAGFVLGAGvvVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHA-LEETP 216
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
31-198 |
6.24e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 45.28 E-value: 6.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 31 AGFMTLLDVSIVNVALPSIRTGLDTPESDLQWV-LSGYALAFGLfLVPSGRLGDARGR-RRVFMAGLVLFTLASAACGAA 108
Cdd:cd17472 202 SIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVyLPAILIGFIL-MVPFVIYAEKKGKmKQVFVSSILLIAVGFLLLLFA 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 109 QSSLWLVISRLVQGVAG-GLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGADEgwrwVFYVN 187
Cdd:cd17472 281 ATSLWLLIIGLIIFFIGfNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSS----VFLTI 356
|
170
....*....|.
gi 2764013522 188 LPIGVLCLVLA 198
Cdd:cd17472 357 LILALLWLLVS 367
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
63-237 |
1.05e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.52 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 63 VLSGYALAFGLFLVPSGRLGDARGRRRVFM-AGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGL-VSpqITALIQQMF 140
Cdd:cd17490 36 ILGAYGISQMLLRIPLGILSDRIGKRKLFIiIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATwVS--FTVLYASYF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 141 RGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAgadeGWRWVFYVNLPIGVLCLVLAHRLLPDTPGARGVRLRELDPLG 220
Cdd:cd17490 114 PPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHF----GMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKELLS 189
|
170 180
....*....|....*....|.
gi 2764013522 221 VL----LLGAGVVALLLPFVQ 237
Cdd:cd17490 190 VLkdkkLLFFSLLAILQQMIT 210
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
85-198 |
1.12e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.52 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 85 RGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGP 164
Cdd:cd17490 258 LGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGP 337
|
90 100 110
....*....|....*....|....*....|....
gi 2764013522 165 LLGGLLIQAAGADegwrWVFYVNLPIGVLCLVLA 198
Cdd:cd17490 338 VLVGIISEAFGLQ----TGFFVIGVIALLAAILS 367
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
3-198 |
1.34e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 3 QQEPASPAPEEAYTPDPNRWKALAVCLVAGFMTLLDVSIVNVALPSI--RTGLDTPesdlqwVLSGYALAFGLFLVP--- 77
Cdd:cd17473 177 ARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLlqERGGGSA------ALIGLALAIASLAGAiga 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 78 --SGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSV 155
Cdd:cd17473 251 llFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA 330
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2764013522 156 VGISTAVGPLLGGLLIQAAGADEGwrwVFYVnlpIGVLCLVLA 198
Cdd:cd17473 331 FFLGQFLSPLVLGPLVNLTGGLSG---AFLI---LGVLALVLA 367
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
68-231 |
1.40e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 44.08 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 68 ALAFGLFLVPS-----------GRLGDARG-RRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITAL 135
Cdd:cd17471 31 PLQIGIFMTLSalsgivvsqwlGRLSDRGGdRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFAL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 136 IQQMF---RGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGadegWRWVFYVNLPIGVLCLVLAHRLLPDTPGAR--- 209
Cdd:cd17471 111 AREYAdrsSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLG----FTGLFLLAALLYLVVALLVLFLLPSVKPPAqka 186
|
170 180
....*....|....*....|....*
gi 2764013522 210 ---GVRLRELDPLGVLLLGAGVVAL 231
Cdd:cd17471 187 tpaSSLVKAPVNRRLLLLFAAFTLL 211
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
24-177 |
1.55e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.70 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 24 ALAVCLVAGFMtlldVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMA-GLVLFTLAS 102
Cdd:cd17477 193 ALLGAFVAGFL----EGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGcALLGALAAL 268
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2764013522 103 AACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGAD 177
Cdd:cd17477 269 LLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPH 343
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
62-201 |
2.16e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 43.33 E-value: 2.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 62 WVLSGYALAFGLFLVPSGRLGD---ARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQ 138
Cdd:cd17319 219 LLAAIPFLAGAIGMILGGRLSDrllRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPAD 298
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2764013522 139 MFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGadeGWRWVFYVNLPIGVLCLVLAHRL 201
Cdd:cd17319 299 LLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATG---SYTAAFLFLAAVALLAALLVLLL 358
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
304-431 |
3.71e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 42.75 E-value: 3.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 304 FFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLG-RPLVVAGLLMVAIGLAGTAFAVHQvtgkgigWAL 382
Cdd:TIGR00881 14 FALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNpRVFLPIGLILCAIVNLFFGFSTSL-------WVM 86
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2764013522 383 IAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIG 431
Cdd:TIGR00881 87 AALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLL 135
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
54-202 |
4.39e-04 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 42.34 E-value: 4.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 54 DTPESDLQWVLSGYALAF------GLFLvpsGRLGDARGRRRVFMAGLVLFTLASAACG----AAQSSLW----LVISRL 119
Cdd:cd17366 33 GDPTAQLLATFATFAVAFlvrplgGLVF---GPLGDKYGRQKVLAITIILMAASTFCIGllptYATIGVWapilLLLARM 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 120 VQGVAGGLVSPQITALIQQMFRGRERG--KAFGAFGSVVGISTAVG--PLLGGLLIQAAGADEGWRWVFYVNLPIGVLCL 195
Cdd:cd17366 110 VQGFSTGGEYGGAATFVAEYAPDRKRGflGSWLEFGTLAGFILGAGlvTLLTLLLTEAQMLDWGWRIPFLIAAPLGLVGL 189
|
....*..
gi 2764013522 196 VLAHRLL 202
Cdd:cd17366 190 YLRRPLL 196
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
79-216 |
9.05e-04 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 41.57 E-value: 9.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 79 GRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGK--AFGAFGSVV 156
Cdd:cd17362 60 GALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLlvSLKELFIVL 139
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 157 GIstAVGPLLGGLLIQAAGadeGWRWVFYVNLPIGVLcLVLAHRLLPDTPGARGVRLREL 216
Cdd:cd17362 140 GI--LLGYVSGYAFADVVG---GWRYMYGLAAPPALL-LGIGMWFLPPSPRWQGNYRKPL 193
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
79-197 |
1.13e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 41.44 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 79 GRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVsPQITALIQQMFRGRERGKAFGAFgSVVGI 158
Cdd:PRK09874 75 GGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFV-PNANALIATQVPRNKSGWALGTL-STGGV 152
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 2764013522 159 STA-VGPLLGGLLiqaagADE-GWRWVFYVNLPIGVLCLVL 197
Cdd:PRK09874 153 SGAlLGPLAGGLL-----ADSyGLRPVFFITASVLFLCFLV 188
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
21-175 |
1.72e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.67 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 21 RWKALAVCLVAGFMTLLDVSIVNVALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTL 100
Cdd:cd17332 219 KNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAIL 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 101 ASA--ACGAAQSSLWLVISRLVQGVAGGLVSPQITALI------QQMFRGRER-GKAFGAFGSVVGISTAVGPLLGGLLI 171
Cdd:cd17332 299 GLLllFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLadvidyGELKTGKRReGIFYSVMTFFRKLGLALAGALVGLIL 378
|
....
gi 2764013522 172 QAAG 175
Cdd:cd17332 379 SLAG 382
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
46-209 |
1.94e-03 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 40.43 E-value: 1.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 46 LPSIRTGLDTPESDLQWVLSGYALAF--GLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGV 123
Cdd:pfam06779 16 LPVMIAEGQFSLSQAGLLAAANYAGYlaGALLASFAWRHGASRLRPALLAGLLATVLLLLAMAATSSFWAVLLIRFLAGV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 124 AGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGADEGWRWVFyvnlpiGVLCLVLAHRLLP 203
Cdd:pfam06779 96 ASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGLQLGLGGSSLWYGA------GVLSAVLTLAVFP 169
|
....*.
gi 2764013522 204 DTPGAR 209
Cdd:pfam06779 170 LLPRRA 175
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
310-444 |
1.97e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.23 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 310 YLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLGRP-LVVAGLLMVAIGLAGTAFAVHqvtgkgiGWALIAPLLF 388
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRyLLPLGPLLTGLGLSLLGFAPN-------YWLLLLLVAL 93
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 2764013522 389 AGLGSGlVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIG--IAAVGSVFFGRLA 444
Cdd:cd17478 94 AGIGSA-AFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGplIAAALVALFGGLG 150
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
62-198 |
2.04e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 40.30 E-value: 2.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 62 WVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFR 141
Cdd:cd17313 285 WGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHS 364
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2764013522 142 GRER--GKAFGAFGSVVGISTAVGPLLGGLLIQAAGADEgwrwVFYVNLPIGVLCLVLA 198
Cdd:cd17313 365 ESGRgqGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGT----VFPVAAVASFLSLVGA 419
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
84-207 |
2.20e-03 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 40.29 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 84 ARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKA----FGAFGSVVGIS 159
Cdd:PRK10213 81 ATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKAlsviFGAVSIALVIA 160
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2764013522 160 TAVGPLLGGLLiqaagadeGWRWVFYVNLPIGVLCLVLAHRLLPDTPG 207
Cdd:PRK10213 161 APLGSFLGELI--------GWRNVFNAAAVMGVLCIFWIIKSLPSLPG 200
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
68-176 |
2.23e-03 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 40.50 E-value: 2.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 68 ALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASA-----ACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFrG 142
Cdd:pfam05977 55 TLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTlltllAGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELV-P 133
|
90 100 110
....*....|....*....|....*....|....*
gi 2764013522 143 RERGKAFGAFGSV-VGISTAVGPLLGGLLIQAAGA 176
Cdd:pfam05977 134 RRDLPAAVALNSVgYNIARSVGPALGGVLLAAFGP 168
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
44-405 |
2.58e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.93 E-value: 2.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 44 VALPSIRTGLDTPESDLQWVLSGYALAFGLFLVPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGV 123
Cdd:cd17393 20 TRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 124 AGGL--VSPQITALIQQMFRGRERGKAFGAFGSvvgISTAVGPLLGGLLIQAAGAdegwrwvfyvnlpigvlclVLAHRL 201
Cdd:cd17393 100 ANGAldVAMNAQGVAVERAYGRPIMSSLHAMWS---LGGLAGALLGAAAIGAGVS-------------------PGVHLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 202 LpdtpgargvrlreldpLGVLLLGAGVVALLLPFVQSRQWPGDEKYLLLVVAAALLAAFAWWerrctrsgaeplldlaly 281
Cdd:cd17393 158 A----------------AAVLLLLAALVAIRALLPGTGEAAEDRPDGAGKPGFLLPNRLLLL------------------ 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 282 rvrsyslgsaLGLLYFAGF---TSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLGRPLVVAGLLM 358
Cdd:cd17393 204 ----------LGLLALAAAlaeGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGAL 273
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 2764013522 359 VAIGLAGTAFAVHQVTGKGIGWAL-------IAPLLFAGLGSGLVISPNQTLTL 405
Cdd:cd17393 274 LAALGLLLALLAPSVWVALAGFALmglglsvVVPLAFSAAGALPGLAAGIAVAR 327
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
294-470 |
2.99e-03 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 40.04 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 294 LLYFAGFTSIFFVSTLYLQSGLHYTALQAGltltpFALG------SGLsaGI-GGRLVDRLG-RPLVVAGLLMVAIGLAG 365
Cdd:PRK11646 20 MLVVLGFFVVFPLISIRFVDQLGWAAVMVG-----IALGlrqfiqQGL--GIfGGAIADRFGaKPMIVTGMLMRAAGFAT 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 366 TAFAvHQvtgkgiGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIGiAAVGSvffgrlad 445
Cdd:PRK11646 93 MAIA-HE------PWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIG-ALLGS-------- 156
|
170 180
....*....|....*....|....*...
gi 2764013522 446 dgWSNAYDHGLIVSVG---FVIAALLVA 470
Cdd:PRK11646 157 --WLLQYDFRLVCATGavlFVLAAAFNA 182
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
45-206 |
3.05e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 39.87 E-value: 3.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 45 ALPSI--RTGLDTPESDLQWVLSGYALAFGLFL--VPSGRLGDARGRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLV 120
Cdd:cd17358 24 ALPSLmsDNSLSLPLTVAQFSWFGSLLTLGALIgaLLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 121 QGVAGGLVSpqitaLIQQMFRGRERGKAF-GAFGSVVGISTAVGPLLGGLLiqaaGADEGWRWVFYVNLpIGVLCLVLAH 199
Cdd:cd17358 104 AGFGGGAAS-----VVVPVYIAEIAPKNVrGALGSLNQLLVNIGILLGYVL----GSFLPWRTLALIGA-IPPVVFLILL 173
|
....*..
gi 2764013522 200 RLLPDTP 206
Cdd:cd17358 174 FFIPESP 180
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
302-469 |
3.28e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 39.92 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 302 SIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDR------LGRPLVVAGLLMVAIGLAGTAFAVHqvtg 375
Cdd:cd17345 20 NNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRsnpkrfLAIGLILSAIINILIGFVPSATSSV---- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 376 kgigWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAI--GIAAVGSVFFGrlaDDGWSNAYD 453
Cdd:cd17345 96 ----GLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLvgPLAGLGLAIFG---DGWWRGAFI 168
|
170
....*....|....*.
gi 2764013522 454 HGLIVSVGFVIAALLV 469
Cdd:cd17345 169 FPAIIAIIVAVIVLFL 184
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|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
318-448 |
3.48e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.59 E-value: 3.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 318 TALQAGLTLTPFALGSGLSAGIGGRLVDRLGRPLVVA-GLLMVAIGLAGTAFAvhqvtgkGIGWALIAPLLFAGLGSGLV 396
Cdd:cd17371 32 DEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLViTILLFAVFTLLCGFA-------QNYWQLLILRALAGLGFGGE 104
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2764013522 397 ISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIGIAAVGSVFFGRLADDGW 448
Cdd:cd17371 105 WAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAW 156
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|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
282-436 |
4.61e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.02 E-value: 4.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 282 RVRSYSLGSALGLLYFAGFTSIFFVSTLYLQSGLHYTALQAGLTLTPFALGSGLSAGIGGRLVDRLGR-PLVVAGLLMVA 360
Cdd:COG0477 11 RRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRkRVLLIGLLLFG 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2764013522 361 IGLAGTAFAVHqvtgkgiGWALIAPLLFAGLGSGLVISPNQTLTLSEVPVRRAGSAGGALQTGQRVGSAIGIAAVG 436
Cdd:COG0477 91 LASLLCGLAPS-------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGG 159
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
79-206 |
6.10e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 38.82 E-value: 6.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 79 GRLGDARGRRRVFMAGLVLFTLASAACGAAQS--------SLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKA-- 148
Cdd:cd17367 61 GRLADRIGRRAALTLSVSLMAAGSLVIAVTPTyatigiwaPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYss 140
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2764013522 149 FGAFGSVVGISTAVGPLLggLLIQAAGADE----GWRWVFYVNLPIGVLCLVLaHRLLPDTP 206
Cdd:cd17367 141 FQYVTLIGGQLLALGVLL--VLQHTLGEDQmaawGWRIPFLLGGVLAVVVLWL-RRGLEETE 199
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
86-227 |
6.34e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.82 E-value: 6.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 86 GRRRVFMAGLVLFTLASAACGAAQSSLWLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPL 165
Cdd:cd06180 62 RARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGL 141
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2764013522 166 L-GGLLIQAAGADEGWRWVFYVNLPIGVLCLVLAHRLLPDTPGARGVRLRELDPLGVLLLGAG 227
Cdd:cd06180 142 LvPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAESAPGLNRPLWRLALA 204
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
30-203 |
6.36e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 38.72 E-value: 6.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 30 VAGFMTLLDVSIVNVALPSI--RTGLDTPESDLQWVLSGYALAFGLFLVpsGRLGDARGRRRVFMAGLVLFTLASAACGA 107
Cdd:cd17365 178 VTFFMGLLLVYLLNSWLPKLmvEAGYSLSQALTITLLLNIGGVIGSLLL--GWLADRFGPKRVLALFFALGAVSLALLGV 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2764013522 108 AQSSL-WLVISRLVQGVAGGLVSPQITALIQQMFRGRERGKAFGAFGSVVGISTAVGPLLGGLLIQAAGADEgwrWVFYV 186
Cdd:cd17365 256 SPASLvLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPE---SVFLA 332
|
170
....*....|....*....
gi 2764013522 187 NLPIGVLC--LVLAHRLLP 203
Cdd:cd17365 333 LAIPAALGalAVLLLRLRR 351
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